Motif 410 (n=70)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | T1566 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A7E2V4 | ZSWIM8 | S1267 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| O14715 | RGPD8 | T1565 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15226 | NKRF | S67 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O15231 | ZNF185 | S132 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O43182 | ARHGAP6 | S663 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43294 | TGFB1I1 | S83 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43933 | PEX1 | S1211 | ochoa | Peroxisomal ATPase PEX1 (EC 3.6.4.-) (Peroxin-1) (Peroxisome biogenesis disorder protein 1) (Peroxisome biogenesis factor 1) | Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:11439091, PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772). {ECO:0000269|PubMed:11439091, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118, ECO:0000269|PubMed:29884772}. |
| O60271 | SPAG9 | S1244 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60343 | TBC1D4 | S551 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60381 | HBP1 | S423 | ochoa | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| P02545 | LMNA | S573 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P07196 | NEFL | S61 | ochoa | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08551}. |
| P10109 | FDX1 | S63 | ochoa | Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin) | Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}. |
| P14866 | HNRNPL | S544 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
| P15407 | FOSL1 | S253 | ochoa | Fos-related antigen 1 (FRA-1) | None |
| P15407 | FOSL1 | S254 | ochoa | Fos-related antigen 1 (FRA-1) | None |
| P15407 | FOSL1 | S255 | ochoa | Fos-related antigen 1 (FRA-1) | None |
| P15408 | FOSL2 | S308 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P15408 | FOSL2 | S309 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P15408 | FOSL2 | S310 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P15884 | TCF4 | S56 | psp | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P18583 | SON | S1491 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P30281 | CCND3 | S274 | ochoa | G1/S-specific cyclin-D3 | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}. |
| P48729 | CSNK1A1 | S313 | ochoa | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}. |
| P49023 | PXN | S85 | ochoa|psp | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49792 | RANBP2 | T2541 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| Q03468 | ERCC6 | S1381 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q07157 | TJP1 | Y1066 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q13613 | MTMR1 | S647 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}. |
| Q13796 | SHROOM2 | S153 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14738 | PPP2R5D | S90 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q14934 | NFATC4 | S274 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14980 | NUMA1 | S192 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15555 | MAPRE2 | S230 | ochoa | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250|UniProtKB:Q8R001, ECO:0000269|PubMed:22373814, ECO:0000269|PubMed:23844040, ECO:0000269|PubMed:26527684, ECO:0000269|PubMed:27030108}. |
| Q2KJY2 | KIF26B | S1619 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2M3G4 | SHROOM1 | S250 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q5F1R6 | DNAJC21 | S513 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5TBA9 | FRY | S1940 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q6P3S1 | DENND1B | S654 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6UUV7 | CRTC3 | S322 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6ZN18 | AEBP2 | S149 | ochoa | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q7Z6Z7 | HUWE1 | S3160 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86XP3 | DDX42 | S46 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8N5C8 | TAB3 | S507 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N699 | MYCT1 | S109 | ochoa | Myc target protein 1 (Myc target in myeloid cells protein 1) | May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). {ECO:0000250}. |
| Q8NCE2 | MTMR14 | S514 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8NFH8 | REPS2 | S241 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8TAE6 | PPP1R14C | S38 | ochoa | Protein phosphatase 1 regulatory subunit 14C (Kinase-enhanced PP1 inhibitor) (PKC-potentiated PP1 inhibitory protein) (Serologically defined breast cancer antigen NY-BR-81) | Inhibitor of the PP1 regulatory subunit PPP1CA. |
| Q8WY36 | BBX | S643 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q92614 | MYO18A | S1069 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92985 | IRF7 | S472 | psp | Interferon regulatory factor 7 (IRF-7) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865, PubMed:28768858). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). {ECO:0000250|UniProtKB:P70434, ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045, ECO:0000269|PubMed:17574024, ECO:0000269|PubMed:28342865, ECO:0000269|PubMed:28768858, ECO:0000269|PubMed:32972995}. |
| Q969V6 | MRTFA | S114 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96D71 | REPS1 | S431 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96QT4 | TRPM7 | S1352 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96QU8 | XPO6 | S214 | ochoa | Exportin-6 (Exp6) (Ran-binding protein 20) | Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. {ECO:0000269|PubMed:14592989}. |
| Q96S38 | RPS6KC1 | S786 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96T23 | RSF1 | S1247 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99504 | EYA3 | S256 | ochoa | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| Q99733 | NAP1L4 | S299 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q99961 | SH3GL1 | S288 | ochoa | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
| Q9BXW9 | FANCD2 | S332 | ochoa | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9GZU3 | TMEM39B | S47 | ochoa | Transmembrane protein 39B | May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. {ECO:0000250|UniProtKB:Q7ZW11}. |
| Q9H019 | MTFR1L | S225 | ochoa | Mitochondrial fission regulator 1-like | Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}. |
| Q9H0B6 | KLC2 | S604 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9P258 | RCC2 | S46 | ochoa | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}. |
| Q9UH99 | SUN2 | S22 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UKG1 | APPL1 | S691 | ochoa | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
| Q9UKX7 | NUP50 | S143 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9UPU5 | USP24 | S1373 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.002172 | 2.663 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.002172 | 2.663 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.002172 | 2.663 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.002486 | 2.605 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.002820 | 2.550 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.002820 | 2.550 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.002820 | 2.550 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.002820 | 2.550 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.002820 | 2.550 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.000876 | 3.058 |
| R-HSA-4839744 | Signaling by APC mutants | 0.002172 | 2.663 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.002486 | 2.605 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.002486 | 2.605 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000298 | 3.525 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.000723 | 3.141 |
| R-HSA-68875 | Mitotic Prophase | 0.000509 | 3.293 |
| R-HSA-1640170 | Cell Cycle | 0.000769 | 3.114 |
| R-HSA-68886 | M Phase | 0.003446 | 2.463 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.003939 | 2.405 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.005700 | 2.244 |
| R-HSA-983189 | Kinesins | 0.004524 | 2.344 |
| R-HSA-199991 | Membrane Trafficking | 0.005051 | 2.297 |
| R-HSA-68882 | Mitotic Anaphase | 0.005892 | 2.230 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.005700 | 2.244 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.005995 | 2.222 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.006597 | 2.181 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.007758 | 2.110 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.007221 | 2.141 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.007761 | 2.110 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.007572 | 2.121 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.008602 | 2.065 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.009125 | 2.040 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.014428 | 1.841 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.013411 | 1.873 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.014123 | 1.850 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.014123 | 1.850 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.015593 | 1.807 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.015593 | 1.807 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.016353 | 1.786 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.017917 | 1.747 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.021228 | 1.673 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.010929 | 1.961 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.010929 | 1.961 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.016978 | 1.770 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.019191 | 1.717 |
| R-HSA-525793 | Myogenesis | 0.010729 | 1.969 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.019543 | 1.709 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.016353 | 1.786 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.014428 | 1.841 |
| R-HSA-68877 | Mitotic Prometaphase | 0.019840 | 1.702 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.011375 | 1.944 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.017127 | 1.766 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.016950 | 1.771 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.020378 | 1.691 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.021255 | 1.673 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.015418 | 1.812 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.021228 | 1.673 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.021255 | 1.673 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.019480 | 1.710 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.018625 | 1.730 |
| R-HSA-70171 | Glycolysis | 0.016978 | 1.770 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.018745 | 1.727 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.014850 | 1.828 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.021712 | 1.663 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.021712 | 1.663 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.022092 | 1.656 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.022092 | 1.656 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.022092 | 1.656 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.022971 | 1.639 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.023116 | 1.636 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.024568 | 1.610 |
| R-HSA-70326 | Glucose metabolism | 0.026069 | 1.584 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 0.028650 | 1.543 |
| R-HSA-5579026 | Defective CYP11A1 causes AICSR | 0.042669 | 1.370 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.047298 | 1.325 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.047298 | 1.325 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.047298 | 1.325 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.079086 | 1.102 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.096778 | 1.014 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.122688 | 0.911 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.122688 | 0.911 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.041086 | 1.386 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.070993 | 1.149 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.114134 | 0.943 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.057588 | 1.240 |
| R-HSA-191650 | Regulation of gap junction activity | 0.028650 | 1.543 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.059105 | 1.228 |
| R-HSA-4641265 | Repression of WNT target genes | 0.074610 | 1.127 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.043713 | 1.359 |
| R-HSA-5635838 | Activation of SMO | 0.092386 | 1.034 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.028650 | 1.543 |
| R-HSA-2395516 | Electron transport from NADPH to Ferredoxin | 0.047298 | 1.325 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.061052 | 1.214 |
| R-HSA-202670 | ERKs are inactivated | 0.070112 | 1.154 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.079086 | 1.102 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.087974 | 1.056 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.027577 | 1.559 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.105497 | 0.977 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.056489 | 1.248 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.083541 | 1.078 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.056489 | 1.248 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.114134 | 0.943 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.096778 | 1.014 |
| R-HSA-8963901 | Chylomicron remodeling | 0.079086 | 1.102 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.114134 | 0.943 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.118421 | 0.927 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.042211 | 1.375 |
| R-HSA-191859 | snRNP Assembly | 0.042211 | 1.375 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.044494 | 1.352 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.028145 | 1.551 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.070112 | 1.154 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.096778 | 1.014 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.087974 | 1.056 |
| R-HSA-9857492 | Protein lipoylation | 0.087974 | 1.056 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.092386 | 1.034 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.122688 | 0.911 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.135367 | 0.868 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.058831 | 1.230 |
| R-HSA-195721 | Signaling by WNT | 0.068899 | 1.162 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.033345 | 1.477 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.038019 | 1.420 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.065593 | 1.183 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.028539 | 1.545 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.122688 | 0.911 |
| R-HSA-177929 | Signaling by EGFR | 0.038872 | 1.410 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.057831 | 1.238 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.114134 | 0.943 |
| R-HSA-1221632 | Meiotic synapsis | 0.035641 | 1.448 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.114134 | 0.943 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.122688 | 0.911 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.122688 | 0.911 |
| R-HSA-198753 | ERK/MAPK targets | 0.118421 | 0.927 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.045653 | 1.341 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.121598 | 0.915 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.047111 | 1.327 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.082279 | 1.085 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.115257 | 0.938 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.105497 | 0.977 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.035484 | 1.450 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.051905 | 1.285 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.087974 | 1.056 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.098301 | 1.007 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.098301 | 1.007 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.098301 | 1.007 |
| R-HSA-450294 | MAP kinase activation | 0.044494 | 1.352 |
| R-HSA-180292 | GAB1 signalosome | 0.105497 | 0.977 |
| R-HSA-448424 | Interleukin-17 signaling | 0.055312 | 1.257 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.129642 | 0.887 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.046360 | 1.334 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.109826 | 0.959 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.104380 | 0.981 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.068437 | 1.165 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.045793 | 1.339 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.057831 | 1.238 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.061682 | 1.210 |
| R-HSA-1500620 | Meiosis | 0.075116 | 1.124 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.045653 | 1.341 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.135367 | 0.868 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.135367 | 0.868 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.048506 | 1.314 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.068288 | 1.166 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.090557 | 1.043 |
| R-HSA-913531 | Interferon Signaling | 0.132822 | 0.877 |
| R-HSA-109581 | Apoptosis | 0.057296 | 1.242 |
| R-HSA-75153 | Apoptotic execution phase | 0.028539 | 1.545 |
| R-HSA-2028269 | Signaling by Hippo | 0.101148 | 0.995 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.104094 | 0.983 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.117339 | 0.931 |
| R-HSA-5357801 | Programmed Cell Death | 0.096263 | 1.017 |
| R-HSA-211000 | Gene Silencing by RNA | 0.113685 | 0.944 |
| R-HSA-1483255 | PI Metabolism | 0.104380 | 0.981 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.077907 | 1.108 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.086470 | 1.063 |
| R-HSA-9679506 | SARS-CoV Infections | 0.060761 | 1.216 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.136166 | 0.866 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.136166 | 0.866 |
| R-HSA-3371556 | Cellular response to heat stress | 0.139455 | 0.856 |
| R-HSA-9620244 | Long-term potentiation | 0.139553 | 0.855 |
| R-HSA-9839394 | TGFBR3 expression | 0.139553 | 0.855 |
| R-HSA-162582 | Signal Transduction | 0.141101 | 0.850 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.141106 | 0.850 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.141106 | 0.850 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.142762 | 0.845 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.143719 | 0.842 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.143719 | 0.842 |
| R-HSA-3295583 | TRP channels | 0.143719 | 0.842 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.143719 | 0.842 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.144421 | 0.840 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.147865 | 0.830 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.147865 | 0.830 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.152780 | 0.816 |
| R-HSA-180024 | DARPP-32 events | 0.156097 | 0.807 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.156097 | 0.807 |
| R-HSA-1474165 | Reproduction | 0.157841 | 0.802 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.160184 | 0.795 |
| R-HSA-182971 | EGFR downregulation | 0.164251 | 0.784 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.168299 | 0.774 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.172328 | 0.764 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.172328 | 0.764 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.174930 | 0.757 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.180327 | 0.744 |
| R-HSA-5673000 | RAF activation | 0.180327 | 0.744 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.181849 | 0.740 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.188250 | 0.725 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.188250 | 0.725 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.192183 | 0.716 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.192183 | 0.716 |
| R-HSA-166520 | Signaling by NTRKs | 0.192303 | 0.716 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.199993 | 0.699 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.199993 | 0.699 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.202836 | 0.693 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.203870 | 0.691 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.204598 | 0.689 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.207728 | 0.683 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.207728 | 0.683 |
| R-HSA-9610379 | HCMV Late Events | 0.208128 | 0.682 |
| R-HSA-162587 | HIV Life Cycle | 0.208128 | 0.682 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.211568 | 0.675 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.211568 | 0.675 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.211568 | 0.675 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.211568 | 0.675 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.211568 | 0.675 |
| R-HSA-877300 | Interferon gamma signaling | 0.211665 | 0.674 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.215389 | 0.667 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.215389 | 0.667 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.222978 | 0.652 |
| R-HSA-69236 | G1 Phase | 0.222978 | 0.652 |
| R-HSA-5619102 | SLC transporter disorders | 0.225868 | 0.646 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.226745 | 0.644 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.226745 | 0.644 |
| R-HSA-774815 | Nucleosome assembly | 0.226745 | 0.644 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.226745 | 0.644 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.226745 | 0.644 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.230493 | 0.637 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.230493 | 0.637 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.230493 | 0.637 |
| R-HSA-72306 | tRNA processing | 0.232999 | 0.633 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.234224 | 0.630 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.237937 | 0.624 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.237937 | 0.624 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.237937 | 0.624 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.241633 | 0.617 |
| R-HSA-168255 | Influenza Infection | 0.249092 | 0.604 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.256238 | 0.591 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.256238 | 0.591 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.262708 | 0.581 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.267009 | 0.573 |
| R-HSA-75893 | TNF signaling | 0.267009 | 0.573 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.274104 | 0.562 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.275986 | 0.559 |
| R-HSA-9033241 | Peroxisomal protein import | 0.277626 | 0.557 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.277626 | 0.557 |
| R-HSA-9609690 | HCMV Early Events | 0.279572 | 0.554 |
| R-HSA-73894 | DNA Repair | 0.279759 | 0.553 |
| R-HSA-211976 | Endogenous sterols | 0.284620 | 0.546 |
| R-HSA-9707616 | Heme signaling | 0.288092 | 0.540 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.291547 | 0.535 |
| R-HSA-8848021 | Signaling by PTK6 | 0.291547 | 0.535 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.291547 | 0.535 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.294985 | 0.530 |
| R-HSA-72172 | mRNA Splicing | 0.295694 | 0.529 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.298408 | 0.525 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.301813 | 0.520 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.305203 | 0.515 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.305203 | 0.515 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.315274 | 0.501 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.318598 | 0.497 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.318598 | 0.497 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.318598 | 0.497 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.325200 | 0.488 |
| R-HSA-4086398 | Ca2+ pathway | 0.325200 | 0.488 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.328478 | 0.483 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.331739 | 0.479 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.334985 | 0.475 |
| R-HSA-162906 | HIV Infection | 0.336624 | 0.473 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.338215 | 0.471 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.341430 | 0.467 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.344630 | 0.463 |
| R-HSA-6806834 | Signaling by MET | 0.347814 | 0.459 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.350982 | 0.455 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.350982 | 0.455 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.363506 | 0.439 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.363506 | 0.439 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.366600 | 0.436 |
| R-HSA-74160 | Gene expression (Transcription) | 0.368675 | 0.433 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.368959 | 0.433 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.371668 | 0.430 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.372743 | 0.429 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.375792 | 0.425 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.375792 | 0.425 |
| R-HSA-9609646 | HCMV Infection | 0.376866 | 0.424 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.387211 | 0.412 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.390820 | 0.408 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.390820 | 0.408 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.399664 | 0.398 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.405490 | 0.392 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.405490 | 0.392 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.406667 | 0.391 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.408382 | 0.389 |
| R-HSA-1280218 | Adaptive Immune System | 0.414513 | 0.382 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.416975 | 0.380 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.419674 | 0.377 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.419812 | 0.377 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.422635 | 0.374 |
| R-HSA-111885 | Opioid Signalling | 0.428241 | 0.368 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.431024 | 0.365 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.431141 | 0.365 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.433793 | 0.363 |
| R-HSA-418346 | Platelet homeostasis | 0.436549 | 0.360 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.439045 | 0.357 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.439292 | 0.357 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.439292 | 0.357 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.442021 | 0.355 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.442694 | 0.354 |
| R-HSA-1483257 | Phospholipid metabolism | 0.452495 | 0.344 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.454120 | 0.343 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.466005 | 0.332 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.471195 | 0.327 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.471195 | 0.327 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.471195 | 0.327 |
| R-HSA-73886 | Chromosome Maintenance | 0.481426 | 0.317 |
| R-HSA-9824446 | Viral Infection Pathways | 0.484980 | 0.314 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.486468 | 0.313 |
| R-HSA-194138 | Signaling by VEGF | 0.493940 | 0.306 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.496928 | 0.304 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.506156 | 0.296 |
| R-HSA-9843745 | Adipogenesis | 0.510960 | 0.292 |
| R-HSA-9909396 | Circadian clock | 0.513345 | 0.290 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.525098 | 0.280 |
| R-HSA-163685 | Integration of energy metabolism | 0.525098 | 0.280 |
| R-HSA-1643685 | Disease | 0.525519 | 0.279 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.529721 | 0.276 |
| R-HSA-1632852 | Macroautophagy | 0.536571 | 0.270 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.545552 | 0.263 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.549978 | 0.260 |
| R-HSA-109582 | Hemostasis | 0.551232 | 0.259 |
| R-HSA-2187338 | Visual phototransduction | 0.552175 | 0.258 |
| R-HSA-9758941 | Gastrulation | 0.556537 | 0.255 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.563002 | 0.249 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.563002 | 0.249 |
| R-HSA-9609507 | Protein localization | 0.565136 | 0.248 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.565136 | 0.248 |
| R-HSA-73887 | Death Receptor Signaling | 0.567260 | 0.246 |
| R-HSA-2262752 | Cellular responses to stress | 0.571255 | 0.243 |
| R-HSA-9612973 | Autophagy | 0.571477 | 0.243 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.579790 | 0.237 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.585565 | 0.232 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.593956 | 0.226 |
| R-HSA-8953854 | Metabolism of RNA | 0.600478 | 0.222 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.603785 | 0.219 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.605722 | 0.218 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.607650 | 0.216 |
| R-HSA-983712 | Ion channel transport | 0.637263 | 0.196 |
| R-HSA-212436 | Generic Transcription Pathway | 0.649138 | 0.188 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.656331 | 0.183 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.661357 | 0.180 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.661357 | 0.180 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.674336 | 0.171 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.677593 | 0.169 |
| R-HSA-397014 | Muscle contraction | 0.677593 | 0.169 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.710655 | 0.148 |
| R-HSA-4839726 | Chromatin organization | 0.731255 | 0.136 |
| R-HSA-5663205 | Infectious disease | 0.735635 | 0.133 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.737334 | 0.132 |
| R-HSA-5688426 | Deubiquitination | 0.739084 | 0.131 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.767062 | 0.115 |
| R-HSA-446728 | Cell junction organization | 0.767062 | 0.115 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.785817 | 0.105 |
| R-HSA-1500931 | Cell-Cell communication | 0.806938 | 0.093 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.810721 | 0.091 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.813510 | 0.090 |
| R-HSA-8957322 | Metabolism of steroids | 0.814431 | 0.089 |
| R-HSA-168256 | Immune System | 0.816063 | 0.088 |
| R-HSA-449147 | Signaling by Interleukins | 0.825243 | 0.083 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.830257 | 0.081 |
| R-HSA-597592 | Post-translational protein modification | 0.835869 | 0.078 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.847800 | 0.072 |
| R-HSA-1266738 | Developmental Biology | 0.854583 | 0.068 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.866900 | 0.062 |
| R-HSA-418594 | G alpha (i) signalling events | 0.877691 | 0.057 |
| R-HSA-5668914 | Diseases of metabolism | 0.889284 | 0.051 |
| R-HSA-168249 | Innate Immune System | 0.900982 | 0.045 |
| R-HSA-6798695 | Neutrophil degranulation | 0.904669 | 0.044 |
| R-HSA-112316 | Neuronal System | 0.909765 | 0.041 |
| R-HSA-211859 | Biological oxidations | 0.931476 | 0.031 |
| R-HSA-422475 | Axon guidance | 0.938637 | 0.028 |
| R-HSA-9675108 | Nervous system development | 0.949050 | 0.023 |
| R-HSA-382551 | Transport of small molecules | 0.958848 | 0.018 |
| R-HSA-392499 | Metabolism of proteins | 0.960335 | 0.018 |
| R-HSA-388396 | GPCR downstream signalling | 0.980729 | 0.008 |
| R-HSA-556833 | Metabolism of lipids | 0.980881 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 0.987389 | 0.006 |
| R-HSA-9709957 | Sensory Perception | 0.998244 | 0.001 |
| R-HSA-1430728 | Metabolism | 0.999734 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GRK1 |
0.695 | 0.352 | -2 | 0.505 |
PIM3 |
0.689 | 0.197 | -3 | 0.767 |
COT |
0.682 | 0.183 | 2 | 0.734 |
PIM1 |
0.681 | 0.171 | -3 | 0.760 |
NDR2 |
0.679 | 0.095 | -3 | 0.758 |
PRKX |
0.678 | 0.089 | -3 | 0.710 |
CLK3 |
0.677 | 0.077 | 1 | 0.495 |
MOS |
0.677 | 0.312 | 1 | 0.520 |
CLK2 |
0.676 | 0.103 | -3 | 0.733 |
PKACB |
0.672 | 0.060 | -2 | 0.286 |
SKMLCK |
0.670 | 0.089 | -2 | 0.376 |
AURC |
0.668 | 0.028 | -2 | 0.285 |
IKKB |
0.668 | 0.050 | -2 | 0.307 |
NDR1 |
0.667 | 0.066 | -3 | 0.763 |
RSK2 |
0.666 | 0.057 | -3 | 0.751 |
SRPK1 |
0.666 | 0.073 | -3 | 0.746 |
RSK4 |
0.665 | 0.078 | -3 | 0.733 |
PKACG |
0.663 | 0.034 | -2 | 0.320 |
BMPR1B |
0.662 | 0.109 | 1 | 0.483 |
MSK1 |
0.662 | 0.058 | -3 | 0.736 |
DYRK4 |
0.662 | 0.055 | 1 | 0.387 |
DYRK2 |
0.662 | 0.034 | 1 | 0.420 |
LATS2 |
0.661 | 0.030 | -5 | 0.718 |
CAMK2G |
0.661 | 0.078 | 2 | 0.764 |
PRKD2 |
0.660 | 0.026 | -3 | 0.745 |
PRKD1 |
0.660 | 0.010 | -3 | 0.763 |
MAPKAPK2 |
0.660 | 0.048 | -3 | 0.732 |
KIS |
0.660 | 0.119 | 1 | 0.417 |
PIM2 |
0.659 | 0.139 | -3 | 0.733 |
P70S6KB |
0.659 | 0.058 | -3 | 0.748 |
HIPK2 |
0.659 | 0.048 | 1 | 0.393 |
GRK7 |
0.659 | 0.142 | 1 | 0.454 |
CDKL1 |
0.658 | 0.073 | -3 | 0.754 |
CDC7 |
0.658 | -0.011 | 1 | 0.487 |
MSK2 |
0.657 | 0.037 | -3 | 0.740 |
CAMK2B |
0.657 | 0.057 | 2 | 0.763 |
HIPK1 |
0.657 | 0.068 | 1 | 0.454 |
P90RSK |
0.656 | 0.031 | -3 | 0.750 |
CAMK1B |
0.656 | 0.031 | -3 | 0.762 |
CAMK2A |
0.656 | 0.060 | 2 | 0.793 |
PRPK |
0.656 | 0.004 | -1 | 0.246 |
IKKA |
0.656 | 0.023 | -2 | 0.296 |
RAF1 |
0.656 | -0.021 | 1 | 0.455 |
PAK1 |
0.655 | 0.010 | -2 | 0.321 |
CK1E |
0.655 | 0.199 | -3 | 0.570 |
AURB |
0.654 | 0.015 | -2 | 0.279 |
MYLK4 |
0.654 | 0.054 | -2 | 0.339 |
DSTYK |
0.654 | 0.034 | 2 | 0.757 |
RIPK3 |
0.654 | 0.066 | 3 | 0.702 |
CLK4 |
0.654 | 0.039 | -3 | 0.752 |
CDKL5 |
0.654 | 0.050 | -3 | 0.756 |
GRK6 |
0.653 | 0.062 | 1 | 0.466 |
PKACA |
0.653 | 0.037 | -2 | 0.265 |
HIPK4 |
0.652 | 0.004 | 1 | 0.461 |
ERK5 |
0.652 | 0.012 | 1 | 0.500 |
CAMLCK |
0.652 | 0.028 | -2 | 0.337 |
PKN3 |
0.652 | 0.019 | -3 | 0.743 |
RSK3 |
0.652 | 0.025 | -3 | 0.732 |
SRPK2 |
0.652 | 0.051 | -3 | 0.699 |
MTOR |
0.652 | -0.071 | 1 | 0.429 |
FAM20C |
0.651 | 0.045 | 2 | 0.555 |
WNK1 |
0.651 | -0.008 | -2 | 0.368 |
DYRK1B |
0.651 | 0.041 | 1 | 0.435 |
AURA |
0.651 | 0.007 | -2 | 0.274 |
TGFBR1 |
0.650 | 0.059 | -2 | 0.344 |
ICK |
0.650 | 0.028 | -3 | 0.772 |
GRK4 |
0.650 | 0.095 | -2 | 0.437 |
HUNK |
0.650 | 0.009 | 2 | 0.665 |
GAK |
0.650 | 0.448 | 1 | 0.737 |
NLK |
0.650 | 0.002 | 1 | 0.493 |
MST4 |
0.650 | 0.002 | 2 | 0.699 |
LATS1 |
0.649 | 0.035 | -3 | 0.755 |
NUAK2 |
0.649 | 0.014 | -3 | 0.765 |
AKT2 |
0.649 | 0.057 | -3 | 0.709 |
GRK5 |
0.649 | 0.002 | -3 | 0.701 |
PASK |
0.649 | 0.134 | -3 | 0.770 |
GCN2 |
0.649 | -0.043 | 2 | 0.686 |
SRPK3 |
0.648 | 0.063 | -3 | 0.715 |
CK1D |
0.648 | 0.197 | -3 | 0.539 |
GRK2 |
0.648 | 0.075 | -2 | 0.377 |
DYRK3 |
0.648 | 0.045 | 1 | 0.439 |
DAPK2 |
0.648 | 0.020 | -3 | 0.760 |
GRK3 |
0.647 | 0.104 | -2 | 0.403 |
PKN2 |
0.647 | -0.004 | -3 | 0.761 |
CAMK2D |
0.647 | -0.025 | -3 | 0.744 |
MAPKAPK3 |
0.647 | -0.015 | -3 | 0.742 |
ALK2 |
0.646 | 0.077 | -2 | 0.372 |
AMPKA1 |
0.646 | -0.016 | -3 | 0.763 |
SGK3 |
0.646 | 0.025 | -3 | 0.747 |
ATR |
0.645 | -0.046 | 1 | 0.463 |
NIK |
0.645 | -0.035 | -3 | 0.748 |
ATM |
0.645 | -0.004 | 1 | 0.421 |
MASTL |
0.645 | 0.002 | -2 | 0.317 |
BMPR2 |
0.645 | -0.064 | -2 | 0.336 |
CK2A2 |
0.645 | 0.089 | 1 | 0.427 |
PKG2 |
0.645 | -0.006 | -2 | 0.286 |
MAK |
0.644 | 0.070 | -2 | 0.272 |
NEK6 |
0.644 | -0.077 | -2 | 0.313 |
PAK3 |
0.644 | -0.034 | -2 | 0.308 |
DYRK1A |
0.643 | 0.027 | 1 | 0.434 |
CLK1 |
0.643 | 0.018 | -3 | 0.734 |
TBK1 |
0.643 | -0.107 | 1 | 0.366 |
PDHK4 |
0.643 | -0.188 | 1 | 0.460 |
AMPKA2 |
0.643 | -0.017 | -3 | 0.756 |
MARK4 |
0.642 | -0.064 | 4 | 0.709 |
CDK18 |
0.642 | -0.000 | 1 | 0.425 |
PAK2 |
0.642 | -0.016 | -2 | 0.314 |
ACVR2B |
0.642 | 0.056 | -2 | 0.316 |
RIPK1 |
0.641 | -0.002 | 1 | 0.476 |
MPSK1 |
0.641 | 0.227 | 1 | 0.662 |
CK2A1 |
0.641 | 0.095 | 1 | 0.411 |
BMPR1A |
0.641 | 0.053 | 1 | 0.457 |
PKCD |
0.641 | -0.047 | 2 | 0.633 |
NEK7 |
0.641 | -0.091 | -3 | 0.676 |
IKKE |
0.641 | -0.104 | 1 | 0.351 |
CAMK1G |
0.641 | 0.039 | -3 | 0.726 |
CAMK4 |
0.641 | -0.027 | -3 | 0.742 |
MLK1 |
0.640 | -0.024 | 2 | 0.662 |
JNK2 |
0.640 | 0.002 | 1 | 0.381 |
PRKD3 |
0.640 | 0.007 | -3 | 0.730 |
JNK3 |
0.640 | 0.005 | 1 | 0.397 |
TGFBR2 |
0.640 | -0.056 | -2 | 0.325 |
CK1A2 |
0.639 | 0.166 | -3 | 0.544 |
BRSK1 |
0.639 | -0.014 | -3 | 0.739 |
ALK4 |
0.638 | 0.011 | -2 | 0.348 |
WNK3 |
0.638 | -0.097 | 1 | 0.443 |
CDK7 |
0.638 | -0.027 | 1 | 0.432 |
PKCB |
0.638 | -0.028 | 2 | 0.580 |
P70S6K |
0.637 | 0.044 | -3 | 0.708 |
DLK |
0.637 | -0.044 | 1 | 0.433 |
ACVR2A |
0.637 | 0.012 | -2 | 0.298 |
BCKDK |
0.637 | -0.107 | -1 | 0.192 |
MNK2 |
0.637 | -0.066 | -2 | 0.298 |
CHAK2 |
0.637 | -0.082 | -1 | 0.216 |
MELK |
0.637 | -0.032 | -3 | 0.747 |
SGK1 |
0.637 | 0.065 | -3 | 0.672 |
AKT1 |
0.637 | 0.028 | -3 | 0.723 |
MNK1 |
0.637 | -0.049 | -2 | 0.306 |
CDK10 |
0.637 | 0.026 | 1 | 0.458 |
DRAK1 |
0.637 | -0.011 | 1 | 0.478 |
AKT3 |
0.636 | 0.050 | -3 | 0.689 |
ULK2 |
0.636 | -0.168 | 2 | 0.625 |
PLK1 |
0.636 | -0.050 | -2 | 0.272 |
DNAPK |
0.636 | -0.029 | 1 | 0.352 |
HIPK3 |
0.636 | 0.021 | 1 | 0.428 |
DAPK1 |
0.635 | 0.070 | -3 | 0.752 |
CDK14 |
0.635 | 0.011 | 1 | 0.458 |
CDK1 |
0.635 | -0.007 | 1 | 0.411 |
ANKRD3 |
0.635 | -0.009 | 1 | 0.489 |
NIM1 |
0.635 | -0.078 | 3 | 0.727 |
DAPK3 |
0.634 | 0.060 | -3 | 0.756 |
QSK |
0.634 | -0.041 | 4 | 0.679 |
GSK3A |
0.634 | 0.079 | 4 | 0.579 |
PBK |
0.634 | 0.293 | 1 | 0.763 |
PKCG |
0.634 | -0.040 | 2 | 0.581 |
PDHK1 |
0.634 | -0.217 | 1 | 0.430 |
MLK2 |
0.633 | -0.085 | 2 | 0.655 |
SIK |
0.633 | -0.033 | -3 | 0.727 |
TSSK1 |
0.633 | -0.069 | -3 | 0.762 |
DCAMKL1 |
0.633 | -0.014 | -3 | 0.748 |
CDK17 |
0.633 | -0.014 | 1 | 0.374 |
TSSK2 |
0.633 | -0.089 | -5 | 0.727 |
CDK8 |
0.633 | -0.049 | 1 | 0.404 |
PKCZ |
0.632 | -0.045 | 2 | 0.607 |
CDK19 |
0.632 | -0.041 | 1 | 0.393 |
P38G |
0.631 | -0.017 | 1 | 0.356 |
PKR |
0.631 | -0.010 | 1 | 0.495 |
CAMK1D |
0.630 | 0.019 | -3 | 0.690 |
IRE1 |
0.630 | -0.049 | 1 | 0.484 |
QIK |
0.630 | -0.075 | -3 | 0.739 |
MLK3 |
0.630 | -0.055 | 2 | 0.589 |
ERK1 |
0.630 | -0.018 | 1 | 0.396 |
CDK13 |
0.630 | -0.043 | 1 | 0.420 |
PAK6 |
0.629 | -0.060 | -2 | 0.270 |
MOK |
0.629 | 0.053 | 1 | 0.488 |
SMMLCK |
0.629 | 0.020 | -3 | 0.749 |
MARK3 |
0.629 | -0.053 | 4 | 0.639 |
TTBK2 |
0.629 | -0.024 | 2 | 0.527 |
PKCA |
0.629 | -0.053 | 2 | 0.571 |
NUAK1 |
0.628 | -0.049 | -3 | 0.732 |
P38B |
0.628 | -0.025 | 1 | 0.386 |
MEKK3 |
0.628 | 0.073 | 1 | 0.426 |
CDK16 |
0.627 | -0.012 | 1 | 0.398 |
P38A |
0.627 | -0.029 | 1 | 0.451 |
ULK1 |
0.627 | -0.166 | -3 | 0.632 |
CDK9 |
0.627 | -0.045 | 1 | 0.426 |
GSK3B |
0.627 | 0.064 | 4 | 0.568 |
BRSK2 |
0.626 | -0.064 | -3 | 0.741 |
NEK9 |
0.626 | -0.175 | 2 | 0.668 |
ROCK2 |
0.625 | 0.042 | -3 | 0.755 |
PLK3 |
0.625 | -0.077 | 2 | 0.695 |
CDK5 |
0.625 | -0.026 | 1 | 0.464 |
YSK4 |
0.625 | -0.097 | 1 | 0.399 |
CDK12 |
0.625 | -0.044 | 1 | 0.391 |
PKCH |
0.625 | -0.063 | 2 | 0.567 |
MST3 |
0.624 | 0.006 | 2 | 0.678 |
ERK2 |
0.624 | -0.032 | 1 | 0.415 |
BIKE |
0.624 | 0.327 | 1 | 0.847 |
MAPKAPK5 |
0.624 | -0.041 | -3 | 0.706 |
DMPK1 |
0.624 | 0.081 | -3 | 0.741 |
MLK4 |
0.624 | -0.056 | 2 | 0.573 |
PRP4 |
0.624 | -0.013 | -3 | 0.650 |
PAK5 |
0.623 | -0.054 | -2 | 0.251 |
SNRK |
0.623 | -0.069 | 2 | 0.563 |
CK1G1 |
0.623 | 0.078 | -3 | 0.558 |
CDK3 |
0.623 | -0.016 | 1 | 0.394 |
TLK2 |
0.623 | -0.104 | 1 | 0.400 |
JNK1 |
0.623 | 0.000 | 1 | 0.386 |
MEK1 |
0.623 | -0.084 | 2 | 0.693 |
VRK2 |
0.623 | -0.101 | 1 | 0.496 |
MRCKA |
0.622 | 0.024 | -3 | 0.732 |
P38D |
0.622 | -0.024 | 1 | 0.383 |
SBK |
0.622 | 0.053 | -3 | 0.641 |
MARK2 |
0.622 | -0.069 | 4 | 0.607 |
PHKG1 |
0.622 | -0.063 | -3 | 0.758 |
SMG1 |
0.622 | -0.091 | 1 | 0.434 |
MARK1 |
0.622 | -0.069 | 4 | 0.662 |
IRE2 |
0.621 | -0.077 | 2 | 0.592 |
WNK4 |
0.621 | -0.065 | -2 | 0.350 |
MRCKB |
0.621 | 0.023 | -3 | 0.724 |
CHK1 |
0.621 | -0.087 | -3 | 0.710 |
BRAF |
0.620 | -0.076 | -4 | 0.737 |
PAK4 |
0.620 | -0.046 | -2 | 0.250 |
CDK2 |
0.619 | -0.049 | 1 | 0.452 |
PERK |
0.619 | -0.057 | -2 | 0.343 |
CRIK |
0.618 | 0.075 | -3 | 0.726 |
CK1A |
0.618 | 0.150 | -3 | 0.474 |
PKCT |
0.617 | -0.065 | 2 | 0.568 |
TLK1 |
0.617 | -0.044 | -2 | 0.362 |
TAO3 |
0.617 | -0.052 | 1 | 0.425 |
NEK2 |
0.617 | -0.170 | 2 | 0.639 |
SSTK |
0.617 | -0.062 | 4 | 0.677 |
PLK4 |
0.616 | -0.095 | 2 | 0.495 |
LKB1 |
0.616 | -0.048 | -3 | 0.677 |
CAMK1A |
0.615 | 0.006 | -3 | 0.690 |
AAK1 |
0.615 | 0.325 | 1 | 0.868 |
MEK5 |
0.615 | -0.090 | 2 | 0.672 |
NEK5 |
0.615 | -0.085 | 1 | 0.500 |
PKCE |
0.615 | -0.022 | 2 | 0.564 |
ROCK1 |
0.615 | 0.028 | -3 | 0.735 |
PINK1 |
0.614 | -0.100 | 1 | 0.564 |
CAMKK1 |
0.614 | -0.115 | -2 | 0.299 |
CAMKK2 |
0.613 | -0.105 | -2 | 0.286 |
TAK1 |
0.613 | 0.034 | 1 | 0.433 |
CHAK1 |
0.613 | -0.156 | 2 | 0.584 |
PKCI |
0.613 | -0.066 | 2 | 0.577 |
GCK |
0.613 | -0.013 | 1 | 0.438 |
MEKK2 |
0.612 | -0.050 | 2 | 0.645 |
DCAMKL2 |
0.612 | -0.057 | -3 | 0.746 |
IRAK4 |
0.612 | -0.091 | 1 | 0.480 |
MEKK1 |
0.612 | -0.101 | 1 | 0.429 |
PKG1 |
0.612 | -0.028 | -2 | 0.250 |
CHK2 |
0.611 | 0.018 | -3 | 0.683 |
HRI |
0.611 | -0.121 | -2 | 0.306 |
HPK1 |
0.610 | -0.024 | 1 | 0.424 |
ZAK |
0.609 | -0.130 | 1 | 0.381 |
NEK11 |
0.609 | -0.050 | 1 | 0.417 |
NEK8 |
0.608 | -0.102 | 2 | 0.663 |
ERK7 |
0.608 | -0.021 | 2 | 0.440 |
PDK1 |
0.608 | -0.056 | 1 | 0.446 |
PLK2 |
0.606 | -0.029 | -3 | 0.543 |
CDK6 |
0.606 | -0.034 | 1 | 0.452 |
CDK4 |
0.605 | -0.045 | 1 | 0.389 |
PKN1 |
0.605 | -0.033 | -3 | 0.722 |
PHKG2 |
0.604 | -0.090 | -3 | 0.734 |
MST2 |
0.604 | -0.060 | 1 | 0.426 |
SLK |
0.602 | -0.096 | -2 | 0.266 |
IRAK1 |
0.602 | -0.120 | -1 | 0.166 |
TAO2 |
0.602 | -0.112 | 2 | 0.685 |
HASPIN |
0.601 | -0.031 | -1 | 0.149 |
CK1G2 |
0.600 | 0.184 | -3 | 0.500 |
ALPHAK3 |
0.599 | 0.048 | -1 | 0.265 |
LRRK2 |
0.599 | -0.104 | 2 | 0.693 |
KHS2 |
0.599 | -0.047 | 1 | 0.421 |
LOK |
0.599 | -0.124 | -2 | 0.272 |
TNIK |
0.599 | -0.086 | 3 | 0.766 |
BUB1 |
0.599 | -0.042 | -5 | 0.671 |
NEK4 |
0.598 | -0.146 | 1 | 0.438 |
MINK |
0.598 | -0.079 | 1 | 0.418 |
TTBK1 |
0.598 | -0.090 | 2 | 0.468 |
MEKK6 |
0.598 | -0.105 | 1 | 0.412 |
STK33 |
0.597 | -0.106 | 2 | 0.490 |
MAP3K15 |
0.596 | -0.115 | 1 | 0.382 |
VRK1 |
0.596 | -0.110 | 2 | 0.662 |
KHS1 |
0.596 | -0.084 | 1 | 0.403 |
HGK |
0.593 | -0.135 | 3 | 0.753 |
NEK1 |
0.593 | -0.151 | 1 | 0.466 |
YANK3 |
0.592 | -0.002 | 2 | 0.332 |
PDHK4_TYR |
0.592 | 0.191 | 2 | 0.791 |
PDHK3_TYR |
0.591 | 0.164 | 4 | 0.813 |
MST1 |
0.591 | -0.110 | 1 | 0.407 |
BMPR2_TYR |
0.591 | 0.273 | -1 | 0.378 |
MAP2K6_TYR |
0.590 | 0.220 | -1 | 0.285 |
OSR1 |
0.590 | -0.056 | 2 | 0.637 |
TTK |
0.589 | -0.010 | -2 | 0.321 |
RIPK2 |
0.589 | -0.148 | 1 | 0.358 |
EEF2K |
0.589 | -0.112 | 3 | 0.712 |
CK1G3 |
0.586 | 0.092 | -3 | 0.439 |
FYN |
0.586 | 0.313 | -1 | 0.391 |
YSK1 |
0.585 | -0.139 | 2 | 0.642 |
PDHK1_TYR |
0.584 | 0.183 | -1 | 0.303 |
SYK |
0.583 | 0.270 | -1 | 0.448 |
MAP2K4_TYR |
0.583 | 0.116 | -1 | 0.254 |
BLK |
0.582 | 0.285 | -1 | 0.350 |
PTK2 |
0.582 | 0.250 | -1 | 0.492 |
LCK |
0.580 | 0.282 | -1 | 0.356 |
EPHA6 |
0.579 | 0.153 | -1 | 0.362 |
TXK |
0.579 | 0.119 | 1 | 0.483 |
TESK1_TYR |
0.578 | 0.011 | 3 | 0.799 |
MEK2 |
0.577 | -0.230 | 2 | 0.641 |
PKMYT1_TYR |
0.577 | 0.088 | 3 | 0.770 |
MYO3B |
0.577 | -0.112 | 2 | 0.650 |
ASK1 |
0.576 | -0.131 | 1 | 0.373 |
NEK3 |
0.575 | -0.199 | 1 | 0.394 |
MAP2K7_TYR |
0.574 | -0.028 | 2 | 0.737 |
PINK1_TYR |
0.573 | 0.008 | 1 | 0.484 |
ZAP70 |
0.573 | 0.164 | -1 | 0.388 |
MYO3A |
0.571 | -0.123 | 1 | 0.416 |
TAO1 |
0.571 | -0.149 | 1 | 0.353 |
EPHB4 |
0.571 | 0.047 | -1 | 0.281 |
YES1 |
0.571 | 0.106 | -1 | 0.237 |
FGR |
0.570 | 0.138 | 1 | 0.566 |
LIMK2_TYR |
0.570 | -0.073 | -3 | 0.735 |
HCK |
0.568 | 0.179 | -1 | 0.322 |
FLT1 |
0.568 | 0.102 | -1 | 0.346 |
JAK3 |
0.568 | 0.050 | 1 | 0.396 |
ABL2 |
0.567 | 0.012 | -1 | 0.226 |
INSRR |
0.567 | 0.046 | 3 | 0.676 |
STLK3 |
0.566 | -0.136 | 1 | 0.354 |
EPHA4 |
0.565 | 0.057 | 2 | 0.705 |
SRC |
0.565 | 0.187 | -1 | 0.310 |
SRMS |
0.565 | 0.025 | 1 | 0.463 |
MET |
0.564 | 0.095 | 3 | 0.727 |
RET |
0.563 | -0.109 | 1 | 0.414 |
BMX |
0.563 | 0.031 | -1 | 0.256 |
YANK2 |
0.563 | -0.014 | 2 | 0.347 |
ITK |
0.562 | 0.033 | -1 | 0.268 |
ABL1 |
0.562 | -0.008 | -1 | 0.210 |
KDR |
0.561 | 0.026 | 3 | 0.696 |
EPHB2 |
0.561 | 0.043 | -1 | 0.289 |
EPHB3 |
0.560 | 0.021 | -1 | 0.282 |
LIMK1_TYR |
0.560 | -0.116 | 2 | 0.692 |
FER |
0.560 | -0.015 | 1 | 0.496 |
MST1R |
0.560 | -0.053 | 3 | 0.748 |
TNK2 |
0.559 | -0.006 | 3 | 0.702 |
DDR1 |
0.558 | -0.101 | 4 | 0.724 |
FGFR2 |
0.558 | -0.041 | 3 | 0.721 |
EPHA5 |
0.557 | 0.046 | 2 | 0.696 |
ERBB4 |
0.557 | 0.121 | 1 | 0.351 |
FGFR3 |
0.556 | 0.006 | 3 | 0.701 |
EPHA8 |
0.556 | 0.082 | -1 | 0.352 |
KIT |
0.556 | -0.029 | 3 | 0.718 |
EPHB1 |
0.555 | -0.027 | 1 | 0.428 |
TYRO3 |
0.554 | -0.130 | 3 | 0.721 |
TYK2 |
0.554 | -0.157 | 1 | 0.411 |
MERTK |
0.554 | -0.054 | 3 | 0.727 |
ERBB2 |
0.554 | 0.029 | 1 | 0.389 |
NEK10_TYR |
0.554 | -0.128 | 1 | 0.367 |
CSF1R |
0.554 | -0.085 | 3 | 0.724 |
WEE1_TYR |
0.553 | -0.041 | -1 | 0.179 |
LYN |
0.553 | 0.116 | 3 | 0.639 |
EPHA3 |
0.553 | 0.013 | 2 | 0.671 |
EPHA7 |
0.552 | 0.009 | 2 | 0.683 |
EGFR |
0.551 | 0.010 | 1 | 0.323 |
ROS1 |
0.551 | -0.125 | 3 | 0.698 |
JAK2 |
0.551 | -0.144 | 1 | 0.393 |
TEC |
0.550 | -0.059 | -1 | 0.183 |
EPHA2 |
0.550 | 0.061 | -1 | 0.351 |
DDR2 |
0.549 | -0.058 | 3 | 0.649 |
FRK |
0.547 | 0.012 | -1 | 0.312 |
FLT3 |
0.547 | -0.099 | 3 | 0.709 |
MATK |
0.547 | -0.050 | -1 | 0.189 |
AXL |
0.546 | -0.122 | 3 | 0.728 |
EPHA1 |
0.546 | -0.036 | 3 | 0.709 |
FGFR4 |
0.545 | -0.031 | -1 | 0.237 |
FGFR1 |
0.545 | -0.120 | 3 | 0.699 |
PTK2B |
0.545 | -0.041 | -1 | 0.187 |
TEK |
0.544 | -0.094 | 3 | 0.656 |
PDGFRB |
0.544 | -0.150 | 3 | 0.728 |
FLT4 |
0.544 | -0.062 | 3 | 0.686 |
NTRK1 |
0.544 | -0.102 | -1 | 0.227 |
PTK6 |
0.543 | -0.126 | -1 | 0.167 |
BTK |
0.543 | -0.097 | -1 | 0.197 |
INSR |
0.542 | -0.061 | 3 | 0.664 |
TNK1 |
0.542 | -0.160 | 3 | 0.711 |
NTRK3 |
0.542 | -0.078 | -1 | 0.218 |
JAK1 |
0.540 | -0.129 | 1 | 0.352 |
LTK |
0.539 | -0.119 | 3 | 0.654 |
IGF1R |
0.537 | -0.020 | 3 | 0.600 |
TNNI3K_TYR |
0.537 | -0.162 | 1 | 0.388 |
NTRK2 |
0.536 | -0.130 | 3 | 0.701 |
CSK |
0.535 | -0.096 | 2 | 0.684 |
ALK |
0.534 | -0.144 | 3 | 0.627 |
PDGFRA |
0.530 | -0.217 | 3 | 0.725 |
MUSK |
0.527 | -0.093 | 1 | 0.356 |
FES |
0.526 | -0.047 | -1 | 0.213 |