Motif 409 (n=92)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A6NKT7 | RGPD3 | S1266 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
O00472 | ELL2 | S305 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
O14715 | RGPD8 | S1265 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
O43314 | PPIP5K2 | S1073 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
O60238 | BNIP3L | S86 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
O60566 | BUB1B | Y660 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
O75052 | NOS1AP | S194 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
O94880 | PHF14 | S602 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
O95238 | SPDEF | S242 | psp | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}. |
O95644 | NFATC1 | S335 | psp | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
P02545 | LMNA | S572 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
P04083 | ANXA1 | S27 | ochoa|psp | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
P04150 | NR3C1 | S201 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
P06213 | INSR | S1216 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
P08913 | ADRA2A | S313 | psp | Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
P0DJD0 | RGPD1 | S1250 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
P0DJD1 | RGPD2 | S1258 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
P15374 | UCHL3 | S151 | ochoa | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}. |
P22681 | CBL | S798 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
P23588 | EIF4B | S312 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
P25054 | APC | S1504 | psp | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
P38398 | BRCA1 | S1461 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
P49792 | RANBP2 | S2241 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P49792 | RANBP2 | S2499 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P52292 | KPNA2 | S88 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
Q06455 | RUNX1T1 | S410 | ochoa | Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:10688654, PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
Q12872 | SFSWAP | S618 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
Q12923 | PTPN13 | S2171 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
Q14008 | CKAP5 | S2005 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
Q14684 | RRP1B | S706 | ochoa|psp | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
Q14980 | NUMA1 | S162 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
Q56P03 | EAPP | S87 | ochoa | E2F-associated phosphoprotein (EAPP) | May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269|PubMed:15716352}. |
Q5JQS6 | GCSAML | S84 | ochoa | Germinal center-associated signaling and motility-like protein | None |
Q5QJE6 | DNTTIP2 | S273 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
Q5T1M5 | FKBP15 | S303 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
Q5T5X7 | BEND3 | S502 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
Q5T5Y3 | CAMSAP1 | S357 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
Q5T8D3 | ACBD5 | S257 | ochoa | Acyl-CoA-binding domain-containing protein 5 | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}. |
Q5VST9 | OBSCN | S4815 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
Q5VWJ9 | SNX30 | S28 | ochoa | Sorting nexin-30 | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}. |
Q5XUX1 | FBXW9 | S22 | ochoa | F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. |
Q6P6C2 | ALKBH5 | S374 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
Q6WKZ4 | RAB11FIP1 | S267 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
Q76I76 | SSH2 | S1217 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
Q7KZ85 | SUPT6H | S1526 | ochoa | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
Q7L0Y3 | TRMT10C | S84 | ochoa | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}. |
Q7Z2W4 | ZC3HAV1 | S635 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
Q7Z3J3 | RGPD4 | S1266 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q7Z3U7 | MON2 | S297 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
Q8IWS0 | PHF6 | S194 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
Q8N5G2 | MACO1 | S227 | ochoa | Macoilin (Macoilin-1) (Transmembrane protein 57) | Plays a role in the regulation of neuronal activity. {ECO:0000269|PubMed:21589894}. |
Q8ND24 | RNF214 | S196 | ochoa | RING finger protein 214 | None |
Q8TEQ0 | SNX29 | S361 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
Q8WVM8 | SCFD1 | S298 | ochoa | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
Q8WXH0 | SYNE2 | S4158 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
Q92538 | GBF1 | S1780 | ochoa | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) | Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:12047556, PubMed:12808027, PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250|UniProtKB:Q9R1D7, ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:16926190, ECO:0000269|PubMed:17666033, ECO:0000269|PubMed:17956946, ECO:0000269|PubMed:18003980, ECO:0000269|PubMed:18063581, ECO:0000269|PubMed:19461073, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:23386609, ECO:0000269|PubMed:23418352, ECO:0000269|PubMed:24213530, ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:19039328, ECO:0000305|PubMed:22573891}. |
Q92576 | PHF3 | S1632 | ochoa | PHD finger protein 3 | None |
Q92613 | JADE3 | S570 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
Q92614 | MYO18A | S102 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
Q92614 | MYO18A | S2006 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
Q92621 | NUP205 | S1167 | ochoa | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
Q92754 | TFAP2C | S23 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
Q92997 | DVL3 | S202 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
Q92997 | DVL3 | S203 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
Q92997 | DVL3 | S204 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
Q96DY7 | MTBP | S546 | ochoa | Mdm2-binding protein (hMTBP) | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}. |
Q96J84 | KIRREL1 | S562 | ochoa | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}. |
Q96MU7 | YTHDC1 | S119 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
Q99640 | PKMYT1 | S473 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
Q99666 | RGPD5 | S1265 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
Q9BY89 | KIAA1671 | S590 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9H3C7 | GGNBP2 | S588 | ochoa | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | May be involved in spermatogenesis. |
Q9H6Y2 | WDR55 | S21 | ochoa | WD repeat-containing protein 55 | Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}. |
Q9HCK1 | ZDBF2 | S534 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
Q9NQW6 | ANLN | S172 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
Q9NYL2 | MAP3K20 | S567 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
Q9NZN5 | ARHGEF12 | S304 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
Q9P0Z9 | PIPOX | S300 | ochoa | Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) | Metabolizes sarcosine and L-pipecolic acid. {ECO:0000269|PubMed:10642506}. |
Q9UH62 | ARMCX3 | S72 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
Q9UKX7 | NUP50 | S142 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
Q9ULL1 | PLEKHG1 | S1285 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
Q9UQ35 | SRRM2 | S1379 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y2H0 | DLGAP4 | S729 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
Q9Y2J4 | AMOTL2 | S180 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
Q9Y462 | ZNF711 | T199 | ochoa | Zinc finger protein 711 (Zinc finger protein 6) | Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}. |
Q9Y478 | PRKAB1 | S181 | ochoa | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
Q9Y4F1 | FARP1 | S862 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
Q9Y5T5 | USP16 | S552 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
Q9Y6R1 | SLC4A4 | S78 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
P12277 | CKB | S129 | Sugiyama | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
O95218 | ZRANB2 | Y183 | Sugiyama | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
P13667 | PDIA4 | S130 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-383280 | Nuclear Receptor transcription pathway | 1.183810e-08 | 7.927 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 1.004339e-04 | 3.998 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.794131e-04 | 3.421 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.234446e-04 | 3.490 |
R-HSA-68875 | Mitotic Prophase | 3.742962e-04 | 3.427 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.123332e-03 | 2.673 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.293690e-03 | 2.639 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.293690e-03 | 2.639 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.659278e-03 | 2.575 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.659278e-03 | 2.575 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.854769e-03 | 2.544 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.154285e-03 | 2.667 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.854769e-03 | 2.544 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 2.759243e-03 | 2.559 |
R-HSA-1169408 | ISG15 antiviral mechanism | 2.817591e-03 | 2.550 |
R-HSA-180746 | Nuclear import of Rev protein | 3.058894e-03 | 2.514 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.271774e-03 | 2.485 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.213139e-03 | 2.375 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.471486e-03 | 2.350 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.724265e-03 | 2.429 |
R-HSA-1474165 | Reproduction | 3.687232e-03 | 2.433 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.471486e-03 | 2.350 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.471486e-03 | 2.350 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.739239e-03 | 2.324 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.964100e-03 | 2.402 |
R-HSA-74160 | Gene expression (Transcription) | 4.797195e-03 | 2.319 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.222371e-03 | 2.206 |
R-HSA-68882 | Mitotic Anaphase | 6.335204e-03 | 2.198 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.462140e-03 | 2.190 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.548477e-03 | 2.184 |
R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 6.931309e-03 | 2.159 |
R-HSA-68886 | M Phase | 7.333523e-03 | 2.135 |
R-HSA-73857 | RNA Polymerase II Transcription | 7.204625e-03 | 2.142 |
R-HSA-1221632 | Meiotic synapsis | 9.115556e-03 | 2.040 |
R-HSA-9827857 | Specification of primordial germ cells | 1.050229e-02 | 1.979 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.142721e-02 | 1.942 |
R-HSA-194441 | Metabolism of non-coding RNA | 1.172321e-02 | 1.931 |
R-HSA-191859 | snRNP Assembly | 1.172321e-02 | 1.931 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 1.267801e-02 | 1.897 |
R-HSA-1483249 | Inositol phosphate metabolism | 1.131306e-02 | 1.946 |
R-HSA-212436 | Generic Transcription Pathway | 1.219383e-02 | 1.914 |
R-HSA-1640170 | Cell Cycle | 1.288045e-02 | 1.890 |
R-HSA-6784531 | tRNA processing in the nucleus | 1.317164e-02 | 1.880 |
R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.381500e-02 | 1.860 |
R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.381500e-02 | 1.860 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.574875e-02 | 1.803 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.546699e-02 | 1.811 |
R-HSA-9734767 | Developmental Cell Lineages | 1.453396e-02 | 1.838 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 1.655943e-02 | 1.781 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.871002e-02 | 1.728 |
R-HSA-429947 | Deadenylation of mRNA | 1.883984e-02 | 1.725 |
R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 2.065140e-02 | 1.685 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.932454e-02 | 1.714 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.249204e-02 | 1.648 |
R-HSA-352238 | Breakdown of the nuclear lamina | 2.065140e-02 | 1.685 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.249204e-02 | 1.648 |
R-HSA-69278 | Cell Cycle, Mitotic | 2.162803e-02 | 1.665 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.256365e-02 | 1.647 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.393707e-02 | 1.621 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.535493e-02 | 1.596 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.599020e-02 | 1.585 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.832377e-02 | 1.548 |
R-HSA-141424 | Amplification of signal from the kinetochores | 2.832377e-02 | 1.548 |
R-HSA-1500620 | Meiosis | 2.756494e-02 | 1.560 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.144763e-02 | 1.502 |
R-HSA-9008059 | Interleukin-37 signaling | 2.641082e-02 | 1.578 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.916531e-02 | 1.535 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.261407e-02 | 1.487 |
R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 3.418360e-02 | 1.466 |
R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 3.418360e-02 | 1.466 |
R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 3.418360e-02 | 1.466 |
R-HSA-9682385 | FLT3 signaling in disease | 3.652262e-02 | 1.437 |
R-HSA-74713 | IRS activation | 4.753047e-02 | 1.323 |
R-HSA-9706377 | FLT3 signaling by CBL mutants | 4.753047e-02 | 1.323 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 4.289993e-02 | 1.368 |
R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 4.088005e-02 | 1.388 |
R-HSA-165159 | MTOR signalling | 4.787033e-02 | 1.320 |
R-HSA-69620 | Cell Cycle Checkpoints | 4.534275e-02 | 1.343 |
R-HSA-72306 | tRNA processing | 4.354776e-02 | 1.361 |
R-HSA-70171 | Glycolysis | 4.289993e-02 | 1.368 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.481970e-02 | 1.349 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.124288e-02 | 1.385 |
R-HSA-5619102 | SLC transporter disorders | 4.081062e-02 | 1.389 |
R-HSA-168255 | Influenza Infection | 5.007654e-02 | 1.300 |
R-HSA-211000 | Gene Silencing by RNA | 5.083122e-02 | 1.294 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.291805e-02 | 1.276 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.362562e-02 | 1.271 |
R-HSA-75153 | Apoptotic execution phase | 5.485605e-02 | 1.261 |
R-HSA-201688 | WNT mediated activation of DVL | 8.010323e-02 | 1.096 |
R-HSA-4839744 | Signaling by APC mutants | 9.282102e-02 | 1.032 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 9.282102e-02 | 1.032 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 9.282102e-02 | 1.032 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 9.282102e-02 | 1.032 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 9.911441e-02 | 1.004 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.053645e-01 | 0.977 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.053645e-01 | 0.977 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.053645e-01 | 0.977 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.053645e-01 | 0.977 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.053645e-01 | 0.977 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.053645e-01 | 0.977 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.238582e-01 | 0.907 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.359763e-01 | 0.867 |
R-HSA-912631 | Regulation of signaling by CBL | 1.538426e-01 | 0.813 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.538426e-01 | 0.813 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.597163e-01 | 0.797 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.597163e-01 | 0.797 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.597163e-01 | 0.797 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.597163e-01 | 0.797 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.655496e-01 | 0.781 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.941195e-01 | 0.712 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.107938e-01 | 0.676 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.162756e-01 | 0.665 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 9.221458e-02 | 1.035 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.467053e-01 | 0.834 |
R-HSA-182971 | EGFR downregulation | 2.271262e-01 | 0.644 |
R-HSA-373753 | Nephrin family interactions | 1.597163e-01 | 0.797 |
R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 8.010323e-02 | 1.096 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.217196e-01 | 0.654 |
R-HSA-8849473 | PTK6 Expression | 6.720877e-02 | 1.173 |
R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 7.367823e-02 | 1.133 |
R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 7.367823e-02 | 1.133 |
R-HSA-2025928 | Calcineurin activates NFAT | 8.010323e-02 | 1.096 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.299381e-01 | 0.886 |
R-HSA-9664420 | Killing mechanisms | 1.299381e-01 | 0.886 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.359763e-01 | 0.867 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.378278e-01 | 0.624 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.558913e-01 | 0.807 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.238582e-01 | 0.907 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.997160e-01 | 0.700 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.378278e-01 | 0.624 |
R-HSA-4791275 | Signaling by WNT in cancer | 2.324955e-01 | 0.634 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.359763e-01 | 0.867 |
R-HSA-69478 | G2/M DNA replication checkpoint | 6.069452e-02 | 1.217 |
R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 8.648406e-02 | 1.063 |
R-HSA-4839748 | Signaling by AMER1 mutants | 9.911441e-02 | 1.004 |
R-HSA-4839735 | Signaling by AXIN mutants | 9.911441e-02 | 1.004 |
R-HSA-9603798 | Class I peroxisomal membrane protein import | 1.299381e-01 | 0.886 |
R-HSA-77387 | Insulin receptor recycling | 2.107938e-01 | 0.676 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.479283e-01 | 0.830 |
R-HSA-6807004 | Negative regulation of MET activity | 1.597163e-01 | 0.797 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 7.974766e-02 | 1.098 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.713428e-01 | 0.766 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.107938e-01 | 0.676 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.162756e-01 | 0.665 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.177361e-01 | 0.929 |
R-HSA-9834899 | Specification of the neural plate border | 1.538426e-01 | 0.813 |
R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 1.997160e-01 | 0.700 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 2.378278e-01 | 0.624 |
R-HSA-68877 | Mitotic Prometaphase | 6.124492e-02 | 1.213 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.865011e-02 | 1.163 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.597163e-01 | 0.797 |
R-HSA-1295596 | Spry regulation of FGF signaling | 1.238582e-01 | 0.907 |
R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 7.367823e-02 | 1.133 |
R-HSA-425381 | Bicarbonate transporters | 9.282102e-02 | 1.032 |
R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 1.299381e-01 | 0.886 |
R-HSA-9945266 | Differentiation of T cells | 1.299381e-01 | 0.886 |
R-HSA-9706369 | Negative regulation of FLT3 | 1.299381e-01 | 0.886 |
R-HSA-5693606 | DNA Double Strand Break Response | 9.648961e-02 | 1.016 |
R-HSA-2467813 | Separation of Sister Chromatids | 1.341485e-01 | 0.872 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 2.378278e-01 | 0.624 |
R-HSA-9768777 | Regulation of NPAS4 gene transcription | 8.010323e-02 | 1.096 |
R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 9.911441e-02 | 1.004 |
R-HSA-6787450 | tRNA modification in the mitochondrion | 1.359763e-01 | 0.867 |
R-HSA-8951664 | Neddylation | 2.358602e-01 | 0.627 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 7.367823e-02 | 1.133 |
R-HSA-9613354 | Lipophagy | 8.010323e-02 | 1.096 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.997160e-01 | 0.700 |
R-HSA-9930044 | Nuclear RNA decay | 2.378278e-01 | 0.624 |
R-HSA-416482 | G alpha (12/13) signalling events | 1.209368e-01 | 0.917 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.419729e-01 | 0.848 |
R-HSA-390696 | Adrenoceptors | 7.367823e-02 | 1.133 |
R-HSA-71288 | Creatine metabolism | 1.597163e-01 | 0.797 |
R-HSA-5689901 | Metalloprotease DUBs | 1.997160e-01 | 0.700 |
R-HSA-9609690 | HCMV Early Events | 1.891350e-01 | 0.723 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 8.648406e-02 | 1.063 |
R-HSA-400685 | Sema4D in semaphorin signaling | 1.941195e-01 | 0.712 |
R-HSA-74749 | Signal attenuation | 8.648406e-02 | 1.063 |
R-HSA-193648 | NRAGE signals death through JNK | 7.373108e-02 | 1.132 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.202789e-01 | 0.920 |
R-HSA-2028269 | Signaling by Hippo | 1.419729e-01 | 0.848 |
R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 1.828098e-01 | 0.738 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.655496e-01 | 0.781 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.655496e-01 | 0.781 |
R-HSA-438064 | Post NMDA receptor activation events | 1.443169e-01 | 0.841 |
R-HSA-1433559 | Regulation of KIT signaling | 1.177361e-01 | 0.929 |
R-HSA-166208 | mTORC1-mediated signalling | 1.770961e-01 | 0.752 |
R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.052741e-01 | 0.688 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.074158e-01 | 0.969 |
R-HSA-6802957 | Oncogenic MAPK signaling | 1.372033e-01 | 0.863 |
R-HSA-9610379 | HCMV Late Events | 1.233129e-01 | 0.909 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.597163e-01 | 0.797 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 1.997160e-01 | 0.700 |
R-HSA-162909 | Host Interactions of HIV factors | 7.226906e-02 | 1.141 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.034787e-01 | 0.691 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.707895e-01 | 0.768 |
R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.053645e-01 | 0.977 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.419369e-01 | 0.848 |
R-HSA-8848021 | Signaling by PTK6 | 8.799762e-02 | 1.056 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 8.799762e-02 | 1.056 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.770961e-01 | 0.752 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.858908e-01 | 0.731 |
R-HSA-156711 | Polo-like kinase mediated events | 1.479283e-01 | 0.830 |
R-HSA-5688426 | Deubiquitination | 1.258515e-01 | 0.900 |
R-HSA-73942 | DNA Damage Reversal | 1.238582e-01 | 0.907 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.096396e-01 | 0.960 |
R-HSA-162582 | Signal Transduction | 6.804388e-02 | 1.167 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.378278e-01 | 0.624 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.419729e-01 | 0.848 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.419729e-01 | 0.848 |
R-HSA-1059683 | Interleukin-6 signaling | 1.115717e-01 | 0.952 |
R-HSA-70326 | Glucose metabolism | 6.395843e-02 | 1.194 |
R-HSA-8863678 | Neurodegenerative Diseases | 1.884842e-01 | 0.725 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.884842e-01 | 0.725 |
R-HSA-9018519 | Estrogen-dependent gene expression | 9.159486e-02 | 1.038 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 9.543359e-02 | 1.020 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.141237e-01 | 0.943 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.052741e-01 | 0.688 |
R-HSA-3371556 | Cellular response to heat stress | 6.865011e-02 | 1.163 |
R-HSA-6783589 | Interleukin-6 family signaling | 1.884842e-01 | 0.725 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 1.012766e-01 | 0.994 |
R-HSA-5619115 | Disorders of transmembrane transporters | 1.164438e-01 | 0.934 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 1.419369e-01 | 0.848 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.784233e-01 | 0.749 |
R-HSA-381070 | IRE1alpha activates chaperones | 1.563389e-01 | 0.806 |
R-HSA-162587 | HIV Life Cycle | 1.233129e-01 | 0.909 |
R-HSA-5693537 | Resolution of D-Loop Structures | 2.431235e-01 | 0.614 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.431235e-01 | 0.614 |
R-HSA-8953854 | Metabolism of RNA | 2.456770e-01 | 0.610 |
R-HSA-162906 | HIV Infection | 2.469345e-01 | 0.607 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.483826e-01 | 0.605 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.483826e-01 | 0.605 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.483826e-01 | 0.605 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.483826e-01 | 0.605 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.536056e-01 | 0.596 |
R-HSA-9694516 | SARS-CoV-2 Infection | 2.556194e-01 | 0.592 |
R-HSA-111933 | Calmodulin induced events | 2.587925e-01 | 0.587 |
R-HSA-111997 | CaM pathway | 2.587925e-01 | 0.587 |
R-HSA-69481 | G2/M Checkpoints | 2.596724e-01 | 0.586 |
R-HSA-4641258 | Degradation of DVL | 2.639438e-01 | 0.578 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.639438e-01 | 0.578 |
R-HSA-5689896 | Ovarian tumor domain proteases | 2.639438e-01 | 0.578 |
R-HSA-71064 | Lysine catabolism | 2.639438e-01 | 0.578 |
R-HSA-8939211 | ESR-mediated signaling | 2.655667e-01 | 0.576 |
R-HSA-6785470 | tRNA processing in the mitochondrion | 2.690596e-01 | 0.570 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.690596e-01 | 0.570 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.690596e-01 | 0.570 |
R-HSA-8868766 | rRNA processing in the mitochondrion | 2.791856e-01 | 0.554 |
R-HSA-9607240 | FLT3 Signaling | 2.841964e-01 | 0.546 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.879348e-01 | 0.541 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 2.891726e-01 | 0.539 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2.891726e-01 | 0.539 |
R-HSA-9609646 | HCMV Infection | 2.900336e-01 | 0.538 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.941146e-01 | 0.531 |
R-HSA-111996 | Ca-dependent events | 2.941146e-01 | 0.531 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 2.956298e-01 | 0.529 |
R-HSA-5654743 | Signaling by FGFR4 | 2.990224e-01 | 0.524 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.990224e-01 | 0.524 |
R-HSA-1433557 | Signaling by SCF-KIT | 2.990224e-01 | 0.524 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.038965e-01 | 0.517 |
R-HSA-375280 | Amine ligand-binding receptors | 3.038965e-01 | 0.517 |
R-HSA-5683826 | Surfactant metabolism | 3.038965e-01 | 0.517 |
R-HSA-5654741 | Signaling by FGFR3 | 3.087370e-01 | 0.510 |
R-HSA-1489509 | DAG and IP3 signaling | 3.087370e-01 | 0.510 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.087370e-01 | 0.510 |
R-HSA-913531 | Interferon Signaling | 3.097145e-01 | 0.509 |
R-HSA-9675135 | Diseases of DNA repair | 3.135441e-01 | 0.504 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 3.186361e-01 | 0.497 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.230592e-01 | 0.491 |
R-HSA-9856651 | MITF-M-dependent gene expression | 3.262698e-01 | 0.486 |
R-HSA-9766229 | Degradation of CDH1 | 3.277676e-01 | 0.484 |
R-HSA-446652 | Interleukin-1 family signaling | 3.313470e-01 | 0.480 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 3.338817e-01 | 0.476 |
R-HSA-9609507 | Protein localization | 3.338817e-01 | 0.476 |
R-HSA-73887 | Death Receptor Signaling | 3.364138e-01 | 0.473 |
R-HSA-912446 | Meiotic recombination | 3.370873e-01 | 0.472 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.416990e-01 | 0.466 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.416990e-01 | 0.466 |
R-HSA-6794361 | Neurexins and neuroligins | 3.416990e-01 | 0.466 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.416990e-01 | 0.466 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.416990e-01 | 0.466 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.416990e-01 | 0.466 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.462788e-01 | 0.461 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.462788e-01 | 0.461 |
R-HSA-445355 | Smooth Muscle Contraction | 3.462788e-01 | 0.461 |
R-HSA-72649 | Translation initiation complex formation | 3.508272e-01 | 0.455 |
R-HSA-5633007 | Regulation of TP53 Activity | 3.515455e-01 | 0.454 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 3.520529e-01 | 0.453 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.553441e-01 | 0.449 |
R-HSA-418597 | G alpha (z) signalling events | 3.553441e-01 | 0.449 |
R-HSA-109581 | Apoptosis | 3.565643e-01 | 0.448 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.598299e-01 | 0.444 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.598299e-01 | 0.444 |
R-HSA-177929 | Signaling by EGFR | 3.598299e-01 | 0.444 |
R-HSA-5654736 | Signaling by FGFR1 | 3.598299e-01 | 0.444 |
R-HSA-9764561 | Regulation of CDH1 Function | 3.642848e-01 | 0.439 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.642848e-01 | 0.439 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.687089e-01 | 0.433 |
R-HSA-9679506 | SARS-CoV Infections | 3.723770e-01 | 0.429 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.731025e-01 | 0.428 |
R-HSA-9033241 | Peroxisomal protein import | 3.731025e-01 | 0.428 |
R-HSA-195721 | Signaling by WNT | 3.809987e-01 | 0.419 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.817990e-01 | 0.418 |
R-HSA-112043 | PLC beta mediated events | 3.817990e-01 | 0.418 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.861024e-01 | 0.413 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.861024e-01 | 0.413 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.903760e-01 | 0.409 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.903760e-01 | 0.409 |
R-HSA-373755 | Semaphorin interactions | 3.903760e-01 | 0.409 |
R-HSA-74751 | Insulin receptor signalling cascade | 3.946201e-01 | 0.404 |
R-HSA-8854518 | AURKA Activation by TPX2 | 4.030208e-01 | 0.395 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.071776e-01 | 0.390 |
R-HSA-112040 | G-protein mediated events | 4.071776e-01 | 0.390 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 4.107570e-01 | 0.386 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.113058e-01 | 0.386 |
R-HSA-69275 | G2/M Transition | 4.179821e-01 | 0.379 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.194769e-01 | 0.377 |
R-HSA-204005 | COPII-mediated vesicle transport | 4.194769e-01 | 0.377 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.194769e-01 | 0.377 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 4.220813e-01 | 0.375 |
R-HSA-453274 | Mitotic G2-G2/M phases | 4.227744e-01 | 0.374 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.235203e-01 | 0.373 |
R-HSA-453276 | Regulation of mitotic cell cycle | 4.235203e-01 | 0.373 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.235203e-01 | 0.373 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.275356e-01 | 0.369 |
R-HSA-5617833 | Cilium Assembly | 4.275468e-01 | 0.369 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.315233e-01 | 0.365 |
R-HSA-4086398 | Ca2+ pathway | 4.315233e-01 | 0.365 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.315233e-01 | 0.365 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.322988e-01 | 0.364 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.354834e-01 | 0.361 |
R-HSA-69473 | G2/M DNA damage checkpoint | 4.354834e-01 | 0.361 |
R-HSA-1226099 | Signaling by FGFR in disease | 4.354834e-01 | 0.361 |
R-HSA-380287 | Centrosome maturation | 4.394162e-01 | 0.357 |
R-HSA-8852135 | Protein ubiquitination | 4.394162e-01 | 0.357 |
R-HSA-5689603 | UCH proteinases | 4.433219e-01 | 0.353 |
R-HSA-4086400 | PCP/CE pathway | 4.510524e-01 | 0.346 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.557417e-01 | 0.341 |
R-HSA-5654738 | Signaling by FGFR2 | 4.586766e-01 | 0.338 |
R-HSA-6806834 | Signaling by MET | 4.586766e-01 | 0.338 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 4.624492e-01 | 0.335 |
R-HSA-5357801 | Programmed Cell Death | 4.649652e-01 | 0.333 |
R-HSA-449147 | Signaling by Interleukins | 4.684935e-01 | 0.329 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.736114e-01 | 0.325 |
R-HSA-390918 | Peroxisomal lipid metabolism | 4.736114e-01 | 0.325 |
R-HSA-6794362 | Protein-protein interactions at synapses | 4.772809e-01 | 0.321 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.808858e-01 | 0.318 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.809250e-01 | 0.318 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.831368e-01 | 0.316 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.845439e-01 | 0.315 |
R-HSA-390466 | Chaperonin-mediated protein folding | 4.881378e-01 | 0.311 |
R-HSA-9645723 | Diseases of programmed cell death | 4.917069e-01 | 0.308 |
R-HSA-9663891 | Selective autophagy | 4.917069e-01 | 0.308 |
R-HSA-73894 | DNA Repair | 4.942151e-01 | 0.306 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.987712e-01 | 0.302 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 4.994547e-01 | 0.302 |
R-HSA-597592 | Post-translational protein modification | 5.063384e-01 | 0.296 |
R-HSA-1266738 | Developmental Biology | 5.069876e-01 | 0.295 |
R-HSA-74752 | Signaling by Insulin receptor | 5.091857e-01 | 0.293 |
R-HSA-391251 | Protein folding | 5.091857e-01 | 0.293 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.260686e-01 | 0.279 |
R-HSA-6807878 | COPI-mediated anterograde transport | 5.260686e-01 | 0.279 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.260686e-01 | 0.279 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.293755e-01 | 0.276 |
R-HSA-190236 | Signaling by FGFR | 5.326595e-01 | 0.274 |
R-HSA-422356 | Regulation of insulin secretion | 5.326595e-01 | 0.274 |
R-HSA-3214847 | HATs acetylate histones | 5.359207e-01 | 0.271 |
R-HSA-9614085 | FOXO-mediated transcription | 5.359207e-01 | 0.271 |
R-HSA-1483255 | PI Metabolism | 5.455699e-01 | 0.263 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.518919e-01 | 0.258 |
R-HSA-111885 | Opioid Signalling | 5.518919e-01 | 0.258 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 5.612118e-01 | 0.251 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.642755e-01 | 0.249 |
R-HSA-9700206 | Signaling by ALK in cancer | 5.642755e-01 | 0.249 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.673181e-01 | 0.246 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.673181e-01 | 0.246 |
R-HSA-418594 | G alpha (i) signalling events | 5.745731e-01 | 0.241 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.851362e-01 | 0.233 |
R-HSA-2262752 | Cellular responses to stress | 5.893718e-01 | 0.230 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.909124e-01 | 0.228 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 5.937706e-01 | 0.226 |
R-HSA-72613 | Eukaryotic Translation Initiation | 5.966090e-01 | 0.224 |
R-HSA-72737 | Cap-dependent Translation Initiation | 5.966090e-01 | 0.224 |
R-HSA-1592230 | Mitochondrial biogenesis | 5.994277e-01 | 0.222 |
R-HSA-5693538 | Homology Directed Repair | 6.022268e-01 | 0.220 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.050066e-01 | 0.218 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.159346e-01 | 0.210 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.231857e-01 | 0.205 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.368995e-01 | 0.196 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.444655e-01 | 0.191 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.466490e-01 | 0.189 |
R-HSA-388396 | GPCR downstream signalling | 6.530424e-01 | 0.185 |
R-HSA-163685 | Integration of energy metabolism | 6.567297e-01 | 0.183 |
R-HSA-112316 | Neuronal System | 6.646388e-01 | 0.177 |
R-HSA-1632852 | Macroautophagy | 6.685746e-01 | 0.175 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 6.754861e-01 | 0.170 |
R-HSA-1500931 | Cell-Cell communication | 6.807589e-01 | 0.167 |
R-HSA-199991 | Membrane Trafficking | 6.884792e-01 | 0.162 |
R-HSA-9758941 | Gastrulation | 6.888834e-01 | 0.162 |
R-HSA-9679191 | Potential therapeutics for SARS | 6.910624e-01 | 0.160 |
R-HSA-112315 | Transmission across Chemical Synapses | 6.916913e-01 | 0.160 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.932262e-01 | 0.159 |
R-HSA-9612973 | Autophagy | 7.038222e-01 | 0.153 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.079582e-01 | 0.150 |
R-HSA-8953897 | Cellular responses to stimuli | 7.092897e-01 | 0.149 |
R-HSA-9006936 | Signaling by TGFB family members | 7.120371e-01 | 0.147 |
R-HSA-9006925 | Intracellular signaling by second messengers | 7.198315e-01 | 0.143 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.353510e-01 | 0.134 |
R-HSA-372790 | Signaling by GPCR | 7.365882e-01 | 0.133 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.372072e-01 | 0.132 |
R-HSA-5689880 | Ub-specific processing proteases | 7.390505e-01 | 0.131 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.390505e-01 | 0.131 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.390505e-01 | 0.131 |
R-HSA-9678108 | SARS-CoV-1 Infection | 7.426987e-01 | 0.129 |
R-HSA-375276 | Peptide ligand-binding receptors | 7.618786e-01 | 0.118 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.744814e-01 | 0.111 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 7.749310e-01 | 0.111 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.780817e-01 | 0.109 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.842526e-01 | 0.106 |
R-HSA-389948 | Co-inhibition by PD-1 | 7.842526e-01 | 0.106 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 7.871824e-01 | 0.104 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.887689e-01 | 0.103 |
R-HSA-72172 | mRNA Splicing | 7.917275e-01 | 0.101 |
R-HSA-397014 | Muscle contraction | 8.031571e-01 | 0.095 |
R-HSA-418990 | Adherens junctions interactions | 8.113192e-01 | 0.091 |
R-HSA-392499 | Metabolism of proteins | 8.139169e-01 | 0.089 |
R-HSA-446203 | Asparagine N-linked glycosylation | 8.167357e-01 | 0.088 |
R-HSA-72312 | rRNA processing | 8.290828e-01 | 0.081 |
R-HSA-3247509 | Chromatin modifying enzymes | 8.314813e-01 | 0.080 |
R-HSA-5653656 | Vesicle-mediated transport | 8.339054e-01 | 0.079 |
R-HSA-4839726 | Chromatin organization | 8.484378e-01 | 0.071 |
R-HSA-421270 | Cell-cell junction organization | 8.505669e-01 | 0.070 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.557610e-01 | 0.068 |
R-HSA-416476 | G alpha (q) signalling events | 8.637018e-01 | 0.064 |
R-HSA-9711123 | Cellular response to chemical stress | 8.675081e-01 | 0.062 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 8.730210e-01 | 0.059 |
R-HSA-446728 | Cell junction organization | 8.765693e-01 | 0.057 |
R-HSA-9824443 | Parasitic Infection Pathways | 8.791659e-01 | 0.056 |
R-HSA-9658195 | Leishmania infection | 8.791659e-01 | 0.056 |
R-HSA-1257604 | PIP3 activates AKT signaling | 8.905851e-01 | 0.050 |
R-HSA-1483257 | Phospholipid metabolism | 8.905851e-01 | 0.050 |
R-HSA-9824446 | Viral Infection Pathways | 9.077869e-01 | 0.042 |
R-HSA-500792 | GPCR ligand binding | 9.284197e-01 | 0.032 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.378203e-01 | 0.028 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 9.396270e-01 | 0.027 |
R-HSA-1280218 | Adaptive Immune System | 9.436957e-01 | 0.025 |
R-HSA-9824439 | Bacterial Infection Pathways | 9.447403e-01 | 0.025 |
R-HSA-1643685 | Disease | 9.473210e-01 | 0.024 |
R-HSA-425407 | SLC-mediated transmembrane transport | 9.474339e-01 | 0.023 |
R-HSA-8978868 | Fatty acid metabolism | 9.510577e-01 | 0.022 |
R-HSA-72766 | Translation | 9.581815e-01 | 0.019 |
R-HSA-5663205 | Infectious disease | 9.600884e-01 | 0.018 |
R-HSA-168256 | Immune System | 9.637393e-01 | 0.016 |
R-HSA-422475 | Axon guidance | 9.818213e-01 | 0.008 |
R-HSA-9675108 | Nervous system development | 9.860816e-01 | 0.006 |
R-HSA-109582 | Hemostasis | 9.967973e-01 | 0.001 |
R-HSA-382551 | Transport of small molecules | 9.992500e-01 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 9.997941e-01 | 0.000 |
R-HSA-168249 | Innate Immune System | 9.999449e-01 | 0.000 |
R-HSA-1430728 | Metabolism | 9.999947e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
GRK1 |
0.817 | 0.357 | -2 | 0.862 |
BMPR1B |
0.807 | 0.333 | 1 | 0.749 |
COT |
0.807 | 0.222 | 2 | 0.870 |
MOS |
0.805 | 0.314 | 1 | 0.629 |
CDC7 |
0.804 | 0.167 | 1 | 0.664 |
GRK6 |
0.797 | 0.232 | 1 | 0.651 |
KIS |
0.796 | 0.097 | 1 | 0.455 |
IKKB |
0.795 | 0.063 | -2 | 0.778 |
GRK5 |
0.793 | 0.151 | -3 | 0.873 |
BMPR1A |
0.793 | 0.272 | 1 | 0.726 |
GRK7 |
0.793 | 0.200 | 1 | 0.595 |
IKKA |
0.791 | 0.091 | -2 | 0.767 |
CK2A2 |
0.791 | 0.240 | 1 | 0.672 |
ACVR2B |
0.789 | 0.284 | -2 | 0.787 |
CLK3 |
0.788 | 0.054 | 1 | 0.565 |
TGFBR1 |
0.787 | 0.196 | -2 | 0.799 |
GRK4 |
0.786 | 0.115 | -2 | 0.863 |
GRK2 |
0.786 | 0.249 | -2 | 0.752 |
DSTYK |
0.786 | 0.046 | 2 | 0.885 |
PIM3 |
0.783 | 0.023 | -3 | 0.800 |
CAMK2G |
0.783 | 0.042 | 2 | 0.817 |
ACVR2A |
0.783 | 0.235 | -2 | 0.768 |
MTOR |
0.783 | -0.080 | 1 | 0.507 |
GRK3 |
0.783 | 0.236 | -2 | 0.719 |
PRPK |
0.782 | -0.047 | -1 | 0.550 |
CK2A1 |
0.782 | 0.234 | 1 | 0.671 |
RAF1 |
0.781 | -0.024 | 1 | 0.561 |
GCN2 |
0.780 | -0.072 | 2 | 0.815 |
IKKE |
0.778 | -0.080 | 1 | 0.447 |
TBK1 |
0.777 | -0.106 | 1 | 0.448 |
ALK2 |
0.777 | 0.154 | -2 | 0.819 |
BMPR2 |
0.777 | -0.041 | -2 | 0.867 |
FAM20C |
0.776 | 0.072 | 2 | 0.650 |
NLK |
0.776 | -0.014 | 1 | 0.558 |
ERK5 |
0.775 | -0.044 | 1 | 0.519 |
NDR2 |
0.775 | -0.028 | -3 | 0.790 |
PDHK4 |
0.774 | -0.197 | 1 | 0.548 |
ALK4 |
0.774 | 0.122 | -2 | 0.824 |
CAMK1B |
0.774 | -0.022 | -3 | 0.816 |
MLK1 |
0.774 | 0.003 | 2 | 0.828 |
HUNK |
0.773 | -0.006 | 2 | 0.845 |
PLK1 |
0.772 | 0.106 | -2 | 0.771 |
CK1E |
0.772 | 0.145 | -3 | 0.610 |
DLK |
0.772 | 0.078 | 1 | 0.568 |
SKMLCK |
0.772 | 0.026 | -2 | 0.829 |
CDKL1 |
0.771 | -0.007 | -3 | 0.778 |
ATR |
0.771 | -0.068 | 1 | 0.499 |
RSK2 |
0.770 | 0.016 | -3 | 0.724 |
HIPK4 |
0.770 | -0.014 | 1 | 0.516 |
CDK1 |
0.770 | 0.022 | 1 | 0.493 |
RIPK3 |
0.769 | -0.028 | 3 | 0.634 |
TGFBR2 |
0.769 | -0.016 | -2 | 0.775 |
CDK8 |
0.769 | -0.022 | 1 | 0.459 |
BCKDK |
0.768 | -0.105 | -1 | 0.515 |
CHAK2 |
0.768 | -0.044 | -1 | 0.567 |
PKN3 |
0.767 | -0.038 | -3 | 0.781 |
JNK3 |
0.767 | 0.018 | 1 | 0.462 |
NEK6 |
0.767 | -0.091 | -2 | 0.828 |
NEK7 |
0.767 | -0.109 | -3 | 0.786 |
DYRK2 |
0.767 | -0.001 | 1 | 0.484 |
SRPK1 |
0.766 | -0.002 | -3 | 0.727 |
ULK2 |
0.766 | -0.166 | 2 | 0.802 |
CAMK2B |
0.766 | 0.028 | 2 | 0.785 |
DRAK1 |
0.766 | 0.176 | 1 | 0.696 |
ATM |
0.765 | -0.047 | 1 | 0.464 |
JNK2 |
0.765 | 0.017 | 1 | 0.449 |
PDHK1 |
0.765 | -0.228 | 1 | 0.508 |
MST4 |
0.765 | -0.047 | 2 | 0.849 |
CK1D |
0.765 | 0.143 | -3 | 0.559 |
MLK3 |
0.764 | 0.002 | 2 | 0.763 |
P38G |
0.764 | 0.013 | 1 | 0.415 |
DAPK2 |
0.764 | -0.013 | -3 | 0.817 |
PIM1 |
0.764 | -0.016 | -3 | 0.744 |
TTBK2 |
0.764 | -0.060 | 2 | 0.722 |
CAMLCK |
0.763 | -0.047 | -2 | 0.815 |
NIK |
0.763 | -0.117 | -3 | 0.831 |
PKN2 |
0.763 | -0.029 | -3 | 0.787 |
NDR1 |
0.763 | -0.065 | -3 | 0.782 |
CDK19 |
0.762 | -0.025 | 1 | 0.437 |
MAPKAPK2 |
0.762 | 0.004 | -3 | 0.669 |
ANKRD3 |
0.762 | -0.042 | 1 | 0.539 |
CDKL5 |
0.761 | -0.035 | -3 | 0.761 |
HIPK2 |
0.761 | 0.017 | 1 | 0.434 |
CDK18 |
0.761 | -0.007 | 1 | 0.435 |
PRKD1 |
0.761 | -0.080 | -3 | 0.748 |
NUAK2 |
0.761 | -0.055 | -3 | 0.779 |
MLK4 |
0.761 | 0.020 | 2 | 0.740 |
ULK1 |
0.761 | -0.130 | -3 | 0.756 |
LATS1 |
0.760 | 0.013 | -3 | 0.801 |
PASK |
0.760 | 0.138 | -3 | 0.819 |
RIPK1 |
0.760 | -0.109 | 1 | 0.503 |
P90RSK |
0.760 | -0.034 | -3 | 0.728 |
WNK1 |
0.759 | -0.114 | -2 | 0.863 |
P70S6KB |
0.759 | -0.034 | -3 | 0.744 |
CK1A2 |
0.759 | 0.135 | -3 | 0.560 |
PLK3 |
0.759 | -0.007 | 2 | 0.777 |
ICK |
0.759 | -0.044 | -3 | 0.794 |
MEK1 |
0.759 | 0.005 | 2 | 0.856 |
MASTL |
0.758 | -0.157 | -2 | 0.817 |
RSK4 |
0.758 | 0.027 | -3 | 0.696 |
CAMK2A |
0.758 | 0.009 | 2 | 0.799 |
CDK13 |
0.758 | -0.037 | 1 | 0.455 |
ERK1 |
0.758 | -0.011 | 1 | 0.428 |
P38B |
0.758 | -0.003 | 1 | 0.437 |
CDK5 |
0.758 | -0.009 | 1 | 0.491 |
RSK3 |
0.757 | -0.050 | -3 | 0.727 |
P38D |
0.757 | 0.016 | 1 | 0.373 |
CDK7 |
0.757 | -0.045 | 1 | 0.476 |
CAMK2D |
0.757 | -0.094 | -3 | 0.767 |
LATS2 |
0.757 | -0.071 | -5 | 0.648 |
PKR |
0.757 | -0.059 | 1 | 0.517 |
CDK17 |
0.757 | -0.010 | 1 | 0.423 |
PKACG |
0.756 | -0.051 | -2 | 0.711 |
SRPK3 |
0.756 | -0.002 | -3 | 0.718 |
TLK2 |
0.756 | -0.057 | 1 | 0.489 |
YSK4 |
0.756 | -0.061 | 1 | 0.491 |
MEKK3 |
0.756 | 0.055 | 1 | 0.524 |
PRP4 |
0.755 | 0.029 | -3 | 0.766 |
PRKD2 |
0.755 | -0.058 | -3 | 0.684 |
SRPK2 |
0.755 | -0.014 | -3 | 0.652 |
MLK2 |
0.755 | -0.126 | 2 | 0.825 |
MARK4 |
0.754 | -0.104 | 4 | 0.807 |
CLK2 |
0.754 | 0.037 | -3 | 0.709 |
HIPK1 |
0.754 | -0.000 | 1 | 0.488 |
DYRK4 |
0.754 | 0.004 | 1 | 0.448 |
AURC |
0.753 | -0.026 | -2 | 0.605 |
WNK3 |
0.753 | -0.219 | 1 | 0.481 |
JNK1 |
0.753 | 0.019 | 1 | 0.463 |
PKCD |
0.753 | -0.080 | 2 | 0.802 |
MAPKAPK3 |
0.753 | -0.076 | -3 | 0.701 |
PLK2 |
0.753 | 0.081 | -3 | 0.844 |
ERK2 |
0.752 | -0.028 | 1 | 0.450 |
IRE1 |
0.752 | -0.118 | 1 | 0.470 |
CDK12 |
0.751 | -0.037 | 1 | 0.436 |
P38A |
0.751 | -0.035 | 1 | 0.474 |
TSSK2 |
0.751 | -0.085 | -5 | 0.720 |
MSK2 |
0.751 | -0.050 | -3 | 0.712 |
AMPKA1 |
0.751 | -0.107 | -3 | 0.787 |
MSK1 |
0.751 | -0.009 | -3 | 0.714 |
GAK |
0.750 | 0.098 | 1 | 0.580 |
NEK9 |
0.750 | -0.208 | 2 | 0.843 |
CDK2 |
0.749 | -0.045 | 1 | 0.547 |
PRKX |
0.749 | 0.017 | -3 | 0.633 |
PAK1 |
0.749 | -0.080 | -2 | 0.739 |
VRK2 |
0.749 | -0.187 | 1 | 0.541 |
MYLK4 |
0.749 | -0.008 | -2 | 0.735 |
AURA |
0.748 | -0.015 | -2 | 0.565 |
CK1G1 |
0.748 | 0.023 | -3 | 0.625 |
BRAF |
0.748 | -0.049 | -4 | 0.747 |
DYRK1B |
0.747 | -0.011 | 1 | 0.473 |
CAMK4 |
0.747 | -0.115 | -3 | 0.755 |
PKACB |
0.747 | -0.018 | -2 | 0.620 |
CDK3 |
0.747 | -0.020 | 1 | 0.437 |
CDK9 |
0.746 | -0.056 | 1 | 0.453 |
CLK4 |
0.746 | -0.032 | -3 | 0.724 |
CDK16 |
0.746 | -0.012 | 1 | 0.426 |
GSK3A |
0.746 | 0.041 | 4 | 0.509 |
NIM1 |
0.746 | -0.148 | 3 | 0.719 |
PKCG |
0.744 | -0.071 | 2 | 0.759 |
CDK14 |
0.744 | -0.023 | 1 | 0.470 |
CK1A |
0.744 | 0.160 | -3 | 0.485 |
DYRK1A |
0.744 | -0.028 | 1 | 0.482 |
SMG1 |
0.744 | -0.137 | 1 | 0.438 |
PKCB |
0.744 | -0.067 | 2 | 0.754 |
TLK1 |
0.743 | -0.085 | -2 | 0.816 |
AMPKA2 |
0.743 | -0.106 | -3 | 0.752 |
PERK |
0.743 | -0.133 | -2 | 0.842 |
ZAK |
0.743 | -0.096 | 1 | 0.482 |
DNAPK |
0.742 | -0.118 | 1 | 0.379 |
TAO3 |
0.741 | -0.042 | 1 | 0.508 |
TSSK1 |
0.741 | -0.124 | -3 | 0.798 |
MST3 |
0.741 | -0.007 | 2 | 0.841 |
PKCA |
0.741 | -0.082 | 2 | 0.750 |
MEKK2 |
0.740 | -0.078 | 2 | 0.817 |
GSK3B |
0.740 | 0.014 | 4 | 0.503 |
TAK1 |
0.740 | 0.055 | 1 | 0.543 |
PAK3 |
0.740 | -0.137 | -2 | 0.737 |
PRKD3 |
0.740 | -0.081 | -3 | 0.683 |
PLK4 |
0.740 | -0.117 | 2 | 0.673 |
SGK3 |
0.740 | -0.058 | -3 | 0.723 |
MEKK1 |
0.739 | -0.142 | 1 | 0.478 |
BRSK1 |
0.739 | -0.050 | -3 | 0.731 |
AURB |
0.739 | -0.057 | -2 | 0.600 |
PIM2 |
0.739 | -0.040 | -3 | 0.698 |
PAK2 |
0.739 | -0.112 | -2 | 0.729 |
MEK5 |
0.739 | -0.143 | 2 | 0.833 |
IRE2 |
0.739 | -0.150 | 2 | 0.769 |
CLK1 |
0.739 | -0.047 | -3 | 0.688 |
QSK |
0.739 | -0.089 | 4 | 0.778 |
PINK1 |
0.738 | -0.163 | 1 | 0.542 |
CDK10 |
0.738 | -0.015 | 1 | 0.465 |
MARK3 |
0.738 | -0.059 | 4 | 0.726 |
HIPK3 |
0.738 | -0.051 | 1 | 0.458 |
DYRK3 |
0.737 | -0.033 | 1 | 0.481 |
QIK |
0.737 | -0.141 | -3 | 0.768 |
AKT2 |
0.737 | -0.034 | -3 | 0.644 |
CHAK1 |
0.737 | -0.179 | 2 | 0.770 |
MPSK1 |
0.737 | -0.058 | 1 | 0.506 |
MST2 |
0.737 | -0.004 | 1 | 0.530 |
PKCH |
0.737 | -0.100 | 2 | 0.750 |
PKCZ |
0.737 | -0.130 | 2 | 0.791 |
NEK2 |
0.736 | -0.202 | 2 | 0.822 |
MARK2 |
0.736 | -0.073 | 4 | 0.699 |
PKG2 |
0.736 | -0.058 | -2 | 0.633 |
MELK |
0.735 | -0.139 | -3 | 0.728 |
TTBK1 |
0.735 | -0.116 | 2 | 0.645 |
NUAK1 |
0.735 | -0.122 | -3 | 0.724 |
CAMK1G |
0.734 | -0.062 | -3 | 0.700 |
CHK1 |
0.734 | -0.139 | -3 | 0.754 |
PAK6 |
0.734 | -0.089 | -2 | 0.657 |
GCK |
0.734 | 0.002 | 1 | 0.564 |
MARK1 |
0.733 | -0.066 | 4 | 0.750 |
MNK2 |
0.733 | -0.136 | -2 | 0.737 |
CAMKK1 |
0.733 | -0.120 | -2 | 0.782 |
HRI |
0.733 | -0.219 | -2 | 0.828 |
DAPK1 |
0.733 | 0.037 | -3 | 0.737 |
NEK11 |
0.733 | -0.077 | 1 | 0.522 |
SIK |
0.732 | -0.105 | -3 | 0.698 |
PHKG1 |
0.732 | -0.142 | -3 | 0.757 |
BMPR2_TYR |
0.731 | 0.398 | -1 | 0.664 |
MAPKAPK5 |
0.731 | -0.123 | -3 | 0.669 |
MNK1 |
0.731 | -0.125 | -2 | 0.754 |
NEK8 |
0.731 | -0.118 | 2 | 0.828 |
NEK5 |
0.730 | -0.192 | 1 | 0.490 |
SMMLCK |
0.730 | -0.057 | -3 | 0.772 |
WNK4 |
0.730 | -0.184 | -2 | 0.855 |
DAPK3 |
0.729 | -0.012 | -3 | 0.743 |
P70S6K |
0.729 | -0.066 | -3 | 0.662 |
PDK1 |
0.728 | -0.105 | 1 | 0.496 |
ERK7 |
0.728 | -0.027 | 2 | 0.562 |
DCAMKL1 |
0.728 | -0.114 | -3 | 0.713 |
HPK1 |
0.727 | -0.026 | 1 | 0.543 |
ALPHAK3 |
0.727 | 0.054 | -1 | 0.542 |
SNRK |
0.727 | -0.172 | 2 | 0.703 |
PKACA |
0.726 | -0.041 | -2 | 0.567 |
MINK |
0.726 | -0.080 | 1 | 0.489 |
PTK2 |
0.726 | 0.378 | -1 | 0.736 |
IRAK1 |
0.726 | -0.185 | -1 | 0.479 |
BRSK2 |
0.726 | -0.150 | -3 | 0.740 |
MAK |
0.725 | -0.003 | -2 | 0.728 |
CDK4 |
0.725 | -0.047 | 1 | 0.427 |
CDK6 |
0.725 | -0.048 | 1 | 0.438 |
PDHK3_TYR |
0.725 | 0.159 | 4 | 0.909 |
CAMKK2 |
0.725 | -0.150 | -2 | 0.773 |
TAO2 |
0.724 | -0.137 | 2 | 0.854 |
IRAK4 |
0.724 | -0.196 | 1 | 0.444 |
LKB1 |
0.724 | -0.152 | -3 | 0.763 |
VRK1 |
0.723 | -0.091 | 2 | 0.853 |
TXK |
0.723 | 0.289 | 1 | 0.666 |
PDHK1_TYR |
0.723 | 0.236 | -1 | 0.625 |
SSTK |
0.722 | -0.105 | 4 | 0.766 |
AKT1 |
0.722 | -0.061 | -3 | 0.651 |
SYK |
0.722 | 0.346 | -1 | 0.681 |
MAP2K6_TYR |
0.722 | 0.204 | -1 | 0.590 |
EEF2K |
0.722 | -0.090 | 3 | 0.700 |
MST1 |
0.721 | -0.088 | 1 | 0.495 |
DCAMKL2 |
0.720 | -0.120 | -3 | 0.727 |
PKCT |
0.720 | -0.130 | 2 | 0.753 |
PDHK4_TYR |
0.720 | 0.170 | 2 | 0.861 |
TNIK |
0.719 | -0.113 | 3 | 0.748 |
OSR1 |
0.719 | 0.001 | 2 | 0.812 |
CAMK1D |
0.718 | -0.076 | -3 | 0.624 |
LRRK2 |
0.718 | -0.174 | 2 | 0.855 |
MAP3K15 |
0.718 | -0.157 | 1 | 0.457 |
EPHA6 |
0.718 | 0.197 | -1 | 0.662 |
PKCI |
0.717 | -0.120 | 2 | 0.766 |
SGK1 |
0.717 | -0.029 | -3 | 0.582 |
SLK |
0.717 | -0.094 | -2 | 0.708 |
KHS2 |
0.716 | -0.055 | 1 | 0.516 |
HGK |
0.716 | -0.154 | 3 | 0.741 |
PKCE |
0.715 | -0.075 | 2 | 0.749 |
MOK |
0.715 | -0.039 | 1 | 0.481 |
MAP2K4_TYR |
0.715 | 0.044 | -1 | 0.562 |
MEKK6 |
0.714 | -0.181 | 1 | 0.467 |
PAK5 |
0.714 | -0.112 | -2 | 0.582 |
PBK |
0.714 | -0.082 | 1 | 0.488 |
ROCK2 |
0.714 | -0.057 | -3 | 0.736 |
PHKG2 |
0.714 | -0.159 | -3 | 0.724 |
AKT3 |
0.713 | -0.039 | -3 | 0.587 |
KHS1 |
0.713 | -0.110 | 1 | 0.481 |
FYN |
0.712 | 0.248 | -1 | 0.644 |
PAK4 |
0.712 | -0.097 | -2 | 0.582 |
NEK4 |
0.711 | -0.243 | 1 | 0.453 |
EPHB4 |
0.711 | 0.105 | -1 | 0.593 |
STK33 |
0.711 | -0.142 | 2 | 0.644 |
TTK |
0.710 | -0.037 | -2 | 0.795 |
LOK |
0.710 | -0.160 | -2 | 0.751 |
MEK2 |
0.710 | -0.209 | 2 | 0.822 |
TESK1_TYR |
0.710 | -0.038 | 3 | 0.791 |
CHK2 |
0.710 | -0.060 | -3 | 0.583 |
RIPK2 |
0.709 | -0.196 | 1 | 0.444 |
CK1G2 |
0.709 | 0.134 | -3 | 0.539 |
MRCKB |
0.709 | -0.075 | -3 | 0.686 |
YANK3 |
0.708 | -0.024 | 2 | 0.416 |
CK1G3 |
0.708 | 0.065 | -3 | 0.447 |
EPHA4 |
0.708 | 0.116 | 2 | 0.780 |
MRCKA |
0.707 | -0.087 | -3 | 0.700 |
PKN1 |
0.707 | -0.100 | -3 | 0.663 |
EPHB2 |
0.707 | 0.125 | -1 | 0.592 |
MAP2K7_TYR |
0.707 | -0.112 | 2 | 0.861 |
LCK |
0.706 | 0.161 | -1 | 0.626 |
PINK1_TYR |
0.706 | -0.044 | 1 | 0.549 |
NEK1 |
0.706 | -0.251 | 1 | 0.460 |
YSK1 |
0.706 | -0.158 | 2 | 0.813 |
PKMYT1_TYR |
0.706 | -0.086 | 3 | 0.752 |
SRMS |
0.706 | 0.115 | 1 | 0.621 |
BUB1 |
0.705 | -0.080 | -5 | 0.665 |
HASPIN |
0.705 | -0.087 | -1 | 0.422 |
FER |
0.704 | 0.042 | 1 | 0.599 |
INSRR |
0.703 | 0.085 | 3 | 0.654 |
BLK |
0.703 | 0.144 | -1 | 0.625 |
EPHB1 |
0.703 | 0.101 | 1 | 0.590 |
BIKE |
0.703 | -0.058 | 1 | 0.494 |
SBK |
0.703 | -0.055 | -3 | 0.517 |
ITK |
0.702 | 0.128 | -1 | 0.547 |
YES1 |
0.701 | 0.020 | -1 | 0.548 |
BMX |
0.701 | 0.104 | -1 | 0.494 |
DMPK1 |
0.701 | -0.057 | -3 | 0.703 |
CAMK1A |
0.700 | -0.090 | -3 | 0.602 |
ABL2 |
0.700 | -0.008 | -1 | 0.517 |
EPHB3 |
0.700 | 0.056 | -1 | 0.586 |
HCK |
0.700 | 0.090 | -1 | 0.598 |
FGR |
0.700 | 0.018 | 1 | 0.568 |
FLT1 |
0.698 | 0.094 | -1 | 0.642 |
ASK1 |
0.698 | -0.162 | 1 | 0.453 |
JAK3 |
0.698 | 0.014 | 1 | 0.468 |
MET |
0.697 | 0.073 | 3 | 0.679 |
EPHA8 |
0.697 | 0.132 | -1 | 0.633 |
ABL1 |
0.696 | -0.036 | -1 | 0.503 |
RET |
0.696 | -0.159 | 1 | 0.465 |
MYO3A |
0.696 | -0.119 | 1 | 0.472 |
EGFR |
0.696 | 0.047 | 1 | 0.445 |
CRIK |
0.695 | -0.060 | -3 | 0.653 |
ROCK1 |
0.695 | -0.081 | -3 | 0.700 |
EPHA7 |
0.695 | 0.078 | 2 | 0.786 |
STLK3 |
0.695 | -0.100 | 1 | 0.448 |
LIMK2_TYR |
0.695 | -0.159 | -3 | 0.822 |
CSF1R |
0.694 | -0.070 | 3 | 0.674 |
SRC |
0.693 | 0.102 | -1 | 0.584 |
EPHA5 |
0.693 | 0.081 | 2 | 0.768 |
KIT |
0.693 | -0.026 | 3 | 0.671 |
MST1R |
0.693 | -0.135 | 3 | 0.701 |
ERBB4 |
0.693 | 0.136 | 1 | 0.521 |
ZAP70 |
0.693 | 0.146 | -1 | 0.600 |
FGFR2 |
0.691 | -0.073 | 3 | 0.705 |
ERBB2 |
0.691 | 0.016 | 1 | 0.501 |
TEC |
0.691 | 0.012 | -1 | 0.458 |
LIMK1_TYR |
0.691 | -0.206 | 2 | 0.859 |
EPHA2 |
0.691 | 0.134 | -1 | 0.618 |
NEK3 |
0.691 | -0.262 | 1 | 0.401 |
MYO3B |
0.691 | -0.155 | 2 | 0.824 |
TYRO3 |
0.691 | -0.127 | 3 | 0.683 |
MERTK |
0.691 | -0.010 | 3 | 0.681 |
PKG1 |
0.690 | -0.099 | -2 | 0.543 |
EPHA3 |
0.689 | 0.022 | 2 | 0.754 |
PTK2B |
0.689 | 0.068 | -1 | 0.482 |
JAK2 |
0.688 | -0.177 | 1 | 0.444 |
ROS1 |
0.688 | -0.142 | 3 | 0.659 |
TAO1 |
0.688 | -0.179 | 1 | 0.415 |
FRK |
0.688 | 0.033 | -1 | 0.590 |
FGFR4 |
0.687 | -0.003 | -1 | 0.525 |
FGFR3 |
0.687 | -0.025 | 3 | 0.673 |
DDR1 |
0.687 | -0.185 | 4 | 0.832 |
TYK2 |
0.686 | -0.251 | 1 | 0.455 |
LYN |
0.686 | 0.043 | 3 | 0.585 |
NTRK1 |
0.685 | -0.066 | -1 | 0.534 |
KDR |
0.685 | -0.057 | 3 | 0.632 |
FLT3 |
0.683 | -0.124 | 3 | 0.669 |
AAK1 |
0.683 | -0.051 | 1 | 0.422 |
NTRK3 |
0.683 | -0.045 | -1 | 0.501 |
WEE1_TYR |
0.683 | -0.076 | -1 | 0.475 |
MATK |
0.683 | -0.043 | -1 | 0.475 |
INSR |
0.682 | -0.041 | 3 | 0.630 |
BTK |
0.681 | -0.099 | -1 | 0.476 |
PDGFRB |
0.681 | -0.161 | 3 | 0.677 |
YANK2 |
0.680 | -0.024 | 2 | 0.436 |
AXL |
0.680 | -0.134 | 3 | 0.675 |
PTK6 |
0.680 | -0.151 | -1 | 0.443 |
FGFR1 |
0.680 | -0.160 | 3 | 0.660 |
TNK2 |
0.680 | -0.146 | 3 | 0.642 |
TEK |
0.678 | -0.124 | 3 | 0.621 |
IGF1R |
0.678 | 0.020 | 3 | 0.577 |
EPHA1 |
0.676 | -0.072 | 3 | 0.649 |
ALK |
0.676 | -0.121 | 3 | 0.602 |
FLT4 |
0.676 | -0.101 | 3 | 0.631 |
CSK |
0.676 | -0.064 | 2 | 0.785 |
NTRK2 |
0.676 | -0.121 | 3 | 0.641 |
NEK10_TYR |
0.674 | -0.212 | 1 | 0.388 |
LTK |
0.674 | -0.147 | 3 | 0.619 |
JAK1 |
0.673 | -0.171 | 1 | 0.417 |
FES |
0.670 | 0.033 | -1 | 0.467 |
PDGFRA |
0.668 | -0.256 | 3 | 0.669 |
TNNI3K_TYR |
0.667 | -0.224 | 1 | 0.433 |
TNK1 |
0.667 | -0.246 | 3 | 0.676 |
DDR2 |
0.666 | -0.130 | 3 | 0.625 |
MUSK |
0.664 | -0.091 | 1 | 0.436 |