Motif 409 (n=92)

Position-wise Probabilities

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uniprot genes site source protein function
A6NKT7 RGPD3 S1266 ochoa RanBP2-like and GRIP domain-containing protein 3 None
O00472 ELL2 S305 ochoa RNA polymerase II elongation factor ELL2 Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}.
O14715 RGPD8 S1265 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O43314 PPIP5K2 S1073 ochoa Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}.
O60238 BNIP3L S86 ochoa BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.
O60566 BUB1B Y660 ochoa Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}.
O75052 NOS1AP S194 ochoa Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}.
O94880 PHF14 S602 ochoa PHD finger protein 14 Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}.
O95238 SPDEF S242 psp SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}.
O95644 NFATC1 S335 psp Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.
P02545 LMNA S572 ochoa Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P04083 ANXA1 S27 ochoa|psp Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}.
P04150 NR3C1 S201 ochoa Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.
P06213 INSR S1216 psp Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}.
P08913 ADRA2A S313 psp Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}.
P0DJD0 RGPD1 S1250 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S1258 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P15374 UCHL3 S151 ochoa Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}.
P22681 CBL S798 ochoa E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}.
P23588 EIF4B S312 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P25054 APC S1504 psp Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P38398 BRCA1 S1461 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P49792 RANBP2 S2241 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2499 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P52292 KPNA2 S88 ochoa Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}.
Q06455 RUNX1T1 S410 ochoa Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:10688654, PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.
Q12872 SFSWAP S618 ochoa Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}.
Q12923 PTPN13 S2171 ochoa Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}.
Q14008 CKAP5 S2005 ochoa Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.
Q14684 RRP1B S706 ochoa|psp Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.
Q14980 NUMA1 S162 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q56P03 EAPP S87 ochoa E2F-associated phosphoprotein (EAPP) May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269|PubMed:15716352}.
Q5JQS6 GCSAML S84 ochoa Germinal center-associated signaling and motility-like protein None
Q5QJE6 DNTTIP2 S273 ochoa Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}.
Q5T1M5 FKBP15 S303 ochoa FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.
Q5T5X7 BEND3 S502 ochoa BEN domain-containing protein 3 Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}.
Q5T5Y3 CAMSAP1 S357 ochoa Calmodulin-regulated spectrin-associated protein 1 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5T8D3 ACBD5 S257 ochoa Acyl-CoA-binding domain-containing protein 5 Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}.
Q5VST9 OBSCN S4815 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q5VWJ9 SNX30 S28 ochoa Sorting nexin-30 Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}.
Q5XUX1 FBXW9 S22 ochoa F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
Q6P6C2 ALKBH5 S374 ochoa RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}.
Q6WKZ4 RAB11FIP1 S267 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q76I76 SSH2 S1217 ochoa Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}.
Q7KZ85 SUPT6H S1526 ochoa Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}.
Q7L0Y3 TRMT10C S84 ochoa tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}.
Q7Z2W4 ZC3HAV1 S635 ochoa Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q7Z3J3 RGPD4 S1266 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z3U7 MON2 S297 ochoa Protein MON2 homolog (Protein SF21) Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.
Q8IWS0 PHF6 S194 ochoa PHD finger protein 6 (PHD-like zinc finger protein) Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}.
Q8N5G2 MACO1 S227 ochoa Macoilin (Macoilin-1) (Transmembrane protein 57) Plays a role in the regulation of neuronal activity. {ECO:0000269|PubMed:21589894}.
Q8ND24 RNF214 S196 ochoa RING finger protein 214 None
Q8TEQ0 SNX29 S361 ochoa Sorting nexin-29 (RUN domain-containing protein 2A) None
Q8WVM8 SCFD1 S298 ochoa Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}.
Q8WXH0 SYNE2 S4158 ochoa Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}.
Q92538 GBF1 S1780 ochoa Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:12047556, PubMed:12808027, PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250|UniProtKB:Q9R1D7, ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:16926190, ECO:0000269|PubMed:17666033, ECO:0000269|PubMed:17956946, ECO:0000269|PubMed:18003980, ECO:0000269|PubMed:18063581, ECO:0000269|PubMed:19461073, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:23386609, ECO:0000269|PubMed:23418352, ECO:0000269|PubMed:24213530, ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:19039328, ECO:0000305|PubMed:22573891}.
Q92576 PHF3 S1632 ochoa PHD finger protein 3 None
Q92613 JADE3 S570 ochoa Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}.
Q92614 MYO18A S102 ochoa Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.
Q92614 MYO18A S2006 ochoa Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.
Q92621 NUP205 S1167 ochoa Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}.
Q92754 TFAP2C S23 ochoa Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}.
Q92997 DVL3 S202 psp Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
Q92997 DVL3 S203 psp Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
Q92997 DVL3 S204 psp Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
Q96DY7 MTBP S546 ochoa Mdm2-binding protein (hMTBP) Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}.
Q96J84 KIRREL1 S562 ochoa Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}.
Q96MU7 YTHDC1 S119 ochoa YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.
Q99640 PKMYT1 S473 ochoa Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}.
Q99666 RGPD5 S1265 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9BY89 KIAA1671 S590 ochoa Uncharacterized protein KIAA1671 None
Q9H3C7 GGNBP2 S588 ochoa Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) May be involved in spermatogenesis.
Q9H6Y2 WDR55 S21 ochoa WD repeat-containing protein 55 Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}.
Q9HCK1 ZDBF2 S534 ochoa DBF4-type zinc finger-containing protein 2 None
Q9NQW6 ANLN S172 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NYL2 MAP3K20 S567 ochoa Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.
Q9NZN5 ARHGEF12 S304 ochoa Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.
Q9P0Z9 PIPOX S300 ochoa Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) Metabolizes sarcosine and L-pipecolic acid. {ECO:0000269|PubMed:10642506}.
Q9UH62 ARMCX3 S72 ochoa Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}.
Q9UKX7 NUP50 S142 ochoa Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}.
Q9ULL1 PLEKHG1 S1285 ochoa Pleckstrin homology domain-containing family G member 1 None
Q9UQ35 SRRM2 S1379 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2H0 DLGAP4 S729 ochoa Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Q9Y2J4 AMOTL2 S180 ochoa Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}.
Q9Y462 ZNF711 T199 ochoa Zinc finger protein 711 (Zinc finger protein 6) Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}.
Q9Y478 PRKAB1 S181 ochoa 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Q9Y4F1 FARP1 S862 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y5T5 USP16 S552 ochoa|psp Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}.
Q9Y6R1 SLC4A4 S78 ochoa Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}.
P12277 CKB S129 Sugiyama Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}.
O95218 ZRANB2 Y183 Sugiyama Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}.
P13667 PDIA4 S130 Sugiyama Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) None
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reactome_id name p -log10_p
R-HSA-383280 Nuclear Receptor transcription pathway 1.183810e-08 7.927
R-HSA-2980766 Nuclear Envelope Breakdown 1.004339e-04 3.998
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 3.794131e-04 3.421
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.234446e-04 3.490
R-HSA-68875 Mitotic Prophase 3.742962e-04 3.427
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.123332e-03 2.673
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.293690e-03 2.639
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.293690e-03 2.639
R-HSA-1855170 IPs transport between nucleus and cytosol 2.659278e-03 2.575
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.659278e-03 2.575
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.854769e-03 2.544
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 2.154285e-03 2.667
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.854769e-03 2.544
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 2.759243e-03 2.559
R-HSA-1169408 ISG15 antiviral mechanism 2.817591e-03 2.550
R-HSA-180746 Nuclear import of Rev protein 3.058894e-03 2.514
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.271774e-03 2.485
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 4.213139e-03 2.375
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 4.471486e-03 2.350
R-HSA-180910 Vpr-mediated nuclear import of PICs 3.724265e-03 2.429
R-HSA-1474165 Reproduction 3.687232e-03 2.433
R-HSA-177243 Interactions of Rev with host cellular proteins 4.471486e-03 2.350
R-HSA-176033 Interactions of Vpr with host cellular proteins 4.471486e-03 2.350
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 4.739239e-03 2.324
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 3.964100e-03 2.402
R-HSA-74160 Gene expression (Transcription) 4.797195e-03 2.319
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 6.222371e-03 2.206
R-HSA-68882 Mitotic Anaphase 6.335204e-03 2.198
R-HSA-2555396 Mitotic Metaphase and Anaphase 6.462140e-03 2.190
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 6.548477e-03 2.184
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 6.931309e-03 2.159
R-HSA-68886 M Phase 7.333523e-03 2.135
R-HSA-73857 RNA Polymerase II Transcription 7.204625e-03 2.142
R-HSA-1221632 Meiotic synapsis 9.115556e-03 2.040
R-HSA-9827857 Specification of primordial germ cells 1.050229e-02 1.979
R-HSA-4419969 Depolymerization of the Nuclear Lamina 1.142721e-02 1.942
R-HSA-194441 Metabolism of non-coding RNA 1.172321e-02 1.931
R-HSA-191859 snRNP Assembly 1.172321e-02 1.931
R-HSA-168325 Viral Messenger RNA Synthesis 1.267801e-02 1.897
R-HSA-1483249 Inositol phosphate metabolism 1.131306e-02 1.946
R-HSA-212436 Generic Transcription Pathway 1.219383e-02 1.914
R-HSA-1640170 Cell Cycle 1.288045e-02 1.890
R-HSA-6784531 tRNA processing in the nucleus 1.317164e-02 1.880
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 1.381500e-02 1.860
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 1.381500e-02 1.860
R-HSA-9816359 Maternal to zygotic transition (MZT) 1.574875e-02 1.803
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 1.546699e-02 1.811
R-HSA-9734767 Developmental Cell Lineages 1.453396e-02 1.838
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 1.655943e-02 1.781
R-HSA-5578749 Transcriptional regulation by small RNAs 1.871002e-02 1.728
R-HSA-429947 Deadenylation of mRNA 1.883984e-02 1.725
R-HSA-5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... 2.065140e-02 1.685
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.932454e-02 1.714
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.249204e-02 1.648
R-HSA-352238 Breakdown of the nuclear lamina 2.065140e-02 1.685
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.249204e-02 1.648
R-HSA-69278 Cell Cycle, Mitotic 2.162803e-02 1.665
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 2.256365e-02 1.647
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 2.393707e-02 1.621
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.535493e-02 1.596
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 2.599020e-02 1.585
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 2.832377e-02 1.548
R-HSA-141424 Amplification of signal from the kinetochores 2.832377e-02 1.548
R-HSA-1500620 Meiosis 2.756494e-02 1.560
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 3.144763e-02 1.502
R-HSA-9008059 Interleukin-37 signaling 2.641082e-02 1.578
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.916531e-02 1.535
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.261407e-02 1.487
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 3.418360e-02 1.466
R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors 3.418360e-02 1.466
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 3.418360e-02 1.466
R-HSA-9682385 FLT3 signaling in disease 3.652262e-02 1.437
R-HSA-74713 IRS activation 4.753047e-02 1.323
R-HSA-9706377 FLT3 signaling by CBL mutants 4.753047e-02 1.323
R-HSA-69618 Mitotic Spindle Checkpoint 4.289993e-02 1.368
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 4.088005e-02 1.388
R-HSA-165159 MTOR signalling 4.787033e-02 1.320
R-HSA-69620 Cell Cycle Checkpoints 4.534275e-02 1.343
R-HSA-72306 tRNA processing 4.354776e-02 1.361
R-HSA-70171 Glycolysis 4.289993e-02 1.368
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 4.481970e-02 1.349
R-HSA-8953750 Transcriptional Regulation by E2F6 4.124288e-02 1.385
R-HSA-5619102 SLC transporter disorders 4.081062e-02 1.389
R-HSA-168255 Influenza Infection 5.007654e-02 1.300
R-HSA-211000 Gene Silencing by RNA 5.083122e-02 1.294
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 5.291805e-02 1.276
R-HSA-3700989 Transcriptional Regulation by TP53 5.362562e-02 1.271
R-HSA-75153 Apoptotic execution phase 5.485605e-02 1.261
R-HSA-201688 WNT mediated activation of DVL 8.010323e-02 1.096
R-HSA-4839744 Signaling by APC mutants 9.282102e-02 1.032
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 9.282102e-02 1.032
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 9.282102e-02 1.032
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 9.282102e-02 1.032
R-HSA-5339716 Signaling by GSK3beta mutants 9.911441e-02 1.004
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 1.053645e-01 0.977
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.053645e-01 0.977
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.053645e-01 0.977
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.053645e-01 0.977
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.053645e-01 0.977
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.053645e-01 0.977
R-HSA-196299 Beta-catenin phosphorylation cascade 1.238582e-01 0.907
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.359763e-01 0.867
R-HSA-912631 Regulation of signaling by CBL 1.538426e-01 0.813
R-HSA-9709603 Impaired BRCA2 binding to PALB2 1.538426e-01 0.813
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 1.597163e-01 0.797
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 1.597163e-01 0.797
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 1.597163e-01 0.797
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 1.597163e-01 0.797
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.655496e-01 0.781
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 1.941195e-01 0.712
R-HSA-9619483 Activation of AMPK downstream of NMDARs 2.107938e-01 0.676
R-HSA-9709570 Impaired BRCA2 binding to RAD51 2.162756e-01 0.665
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 9.221458e-02 1.035
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.467053e-01 0.834
R-HSA-182971 EGFR downregulation 2.271262e-01 0.644
R-HSA-373753 Nephrin family interactions 1.597163e-01 0.797
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 8.010323e-02 1.096
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 2.217196e-01 0.654
R-HSA-8849473 PTK6 Expression 6.720877e-02 1.173
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 7.367823e-02 1.133
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 7.367823e-02 1.133
R-HSA-2025928 Calcineurin activates NFAT 8.010323e-02 1.096
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 1.299381e-01 0.886
R-HSA-9664420 Killing mechanisms 1.299381e-01 0.886
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.359763e-01 0.867
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 2.378278e-01 0.624
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.558913e-01 0.807
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 1.238582e-01 0.907
R-HSA-9703465 Signaling by FLT3 fusion proteins 1.997160e-01 0.700
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 2.378278e-01 0.624
R-HSA-4791275 Signaling by WNT in cancer 2.324955e-01 0.634
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 1.359763e-01 0.867
R-HSA-69478 G2/M DNA replication checkpoint 6.069452e-02 1.217
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8.648406e-02 1.063
R-HSA-4839748 Signaling by AMER1 mutants 9.911441e-02 1.004
R-HSA-4839735 Signaling by AXIN mutants 9.911441e-02 1.004
R-HSA-9603798 Class I peroxisomal membrane protein import 1.299381e-01 0.886
R-HSA-77387 Insulin receptor recycling 2.107938e-01 0.676
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 1.479283e-01 0.830
R-HSA-6807004 Negative regulation of MET activity 1.597163e-01 0.797
R-HSA-429914 Deadenylation-dependent mRNA decay 7.974766e-02 1.098
R-HSA-8876384 Listeria monocytogenes entry into host cells 1.713428e-01 0.766
R-HSA-5654732 Negative regulation of FGFR3 signaling 2.107938e-01 0.676
R-HSA-5654733 Negative regulation of FGFR4 signaling 2.162756e-01 0.665
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 1.177361e-01 0.929
R-HSA-9834899 Specification of the neural plate border 1.538426e-01 0.813
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 1.997160e-01 0.700
R-HSA-5654726 Negative regulation of FGFR1 signaling 2.378278e-01 0.624
R-HSA-68877 Mitotic Prometaphase 6.124492e-02 1.213
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 6.865011e-02 1.163
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 1.597163e-01 0.797
R-HSA-1295596 Spry regulation of FGF signaling 1.238582e-01 0.907
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 7.367823e-02 1.133
R-HSA-425381 Bicarbonate transporters 9.282102e-02 1.032
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 1.299381e-01 0.886
R-HSA-9945266 Differentiation of T cells 1.299381e-01 0.886
R-HSA-9706369 Negative regulation of FLT3 1.299381e-01 0.886
R-HSA-5693606 DNA Double Strand Break Response 9.648961e-02 1.016
R-HSA-2467813 Separation of Sister Chromatids 1.341485e-01 0.872
R-HSA-1839124 FGFR1 mutant receptor activation 2.378278e-01 0.624
R-HSA-9768777 Regulation of NPAS4 gene transcription 8.010323e-02 1.096
R-HSA-5693548 Sensing of DNA Double Strand Breaks 9.911441e-02 1.004
R-HSA-6787450 tRNA modification in the mitochondrion 1.359763e-01 0.867
R-HSA-8951664 Neddylation 2.358602e-01 0.627
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 7.367823e-02 1.133
R-HSA-9613354 Lipophagy 8.010323e-02 1.096
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 1.997160e-01 0.700
R-HSA-9930044 Nuclear RNA decay 2.378278e-01 0.624
R-HSA-416482 G alpha (12/13) signalling events 1.209368e-01 0.917
R-HSA-9768759 Regulation of NPAS4 gene expression 1.419729e-01 0.848
R-HSA-390696 Adrenoceptors 7.367823e-02 1.133
R-HSA-71288 Creatine metabolism 1.597163e-01 0.797
R-HSA-5689901 Metalloprotease DUBs 1.997160e-01 0.700
R-HSA-9609690 HCMV Early Events 1.891350e-01 0.723
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 8.648406e-02 1.063
R-HSA-400685 Sema4D in semaphorin signaling 1.941195e-01 0.712
R-HSA-74749 Signal attenuation 8.648406e-02 1.063
R-HSA-193648 NRAGE signals death through JNK 7.373108e-02 1.132
R-HSA-168273 Influenza Viral RNA Transcription and Replication 1.202789e-01 0.920
R-HSA-2028269 Signaling by Hippo 1.419729e-01 0.848
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 1.828098e-01 0.738
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 1.655496e-01 0.781
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1.655496e-01 0.781
R-HSA-438064 Post NMDA receptor activation events 1.443169e-01 0.841
R-HSA-1433559 Regulation of KIT signaling 1.177361e-01 0.929
R-HSA-166208 mTORC1-mediated signalling 1.770961e-01 0.752
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 2.052741e-01 0.688
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.074158e-01 0.969
R-HSA-6802957 Oncogenic MAPK signaling 1.372033e-01 0.863
R-HSA-9610379 HCMV Late Events 1.233129e-01 0.909
R-HSA-5620916 VxPx cargo-targeting to cilium 1.597163e-01 0.797
R-HSA-1643713 Signaling by EGFR in Cancer 1.997160e-01 0.700
R-HSA-162909 Host Interactions of HIV factors 7.226906e-02 1.141
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.034787e-01 0.691
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.707895e-01 0.768
R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases 1.053645e-01 0.977
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.419369e-01 0.848
R-HSA-8848021 Signaling by PTK6 8.799762e-02 1.056
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 8.799762e-02 1.056
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 1.770961e-01 0.752
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 1.858908e-01 0.731
R-HSA-156711 Polo-like kinase mediated events 1.479283e-01 0.830
R-HSA-5688426 Deubiquitination 1.258515e-01 0.900
R-HSA-73942 DNA Damage Reversal 1.238582e-01 0.907
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.096396e-01 0.960
R-HSA-162582 Signal Transduction 6.804388e-02 1.167
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 2.378278e-01 0.624
R-HSA-5637810 Constitutive Signaling by EGFRvIII 1.419729e-01 0.848
R-HSA-5637812 Signaling by EGFRvIII in Cancer 1.419729e-01 0.848
R-HSA-1059683 Interleukin-6 signaling 1.115717e-01 0.952
R-HSA-70326 Glucose metabolism 6.395843e-02 1.194
R-HSA-8863678 Neurodegenerative Diseases 1.884842e-01 0.725
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 1.884842e-01 0.725
R-HSA-9018519 Estrogen-dependent gene expression 9.159486e-02 1.038
R-HSA-9705683 SARS-CoV-2-host interactions 9.543359e-02 1.020
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 1.141237e-01 0.943
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.052741e-01 0.688
R-HSA-3371556 Cellular response to heat stress 6.865011e-02 1.163
R-HSA-6783589 Interleukin-6 family signaling 1.884842e-01 0.725
R-HSA-162599 Late Phase of HIV Life Cycle 1.012766e-01 0.994
R-HSA-5619115 Disorders of transmembrane transporters 1.164438e-01 0.934
R-HSA-381038 XBP1(S) activates chaperone genes 1.419369e-01 0.848
R-HSA-193704 p75 NTR receptor-mediated signalling 1.784233e-01 0.749
R-HSA-381070 IRE1alpha activates chaperones 1.563389e-01 0.806
R-HSA-162587 HIV Life Cycle 1.233129e-01 0.909
R-HSA-5693537 Resolution of D-Loop Structures 2.431235e-01 0.614
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 2.431235e-01 0.614
R-HSA-8953854 Metabolism of RNA 2.456770e-01 0.610
R-HSA-162906 HIV Infection 2.469345e-01 0.607
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 2.483826e-01 0.605
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 2.483826e-01 0.605
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 2.483826e-01 0.605
R-HSA-5654727 Negative regulation of FGFR2 signaling 2.483826e-01 0.605
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 2.536056e-01 0.596
R-HSA-9694516 SARS-CoV-2 Infection 2.556194e-01 0.592
R-HSA-111933 Calmodulin induced events 2.587925e-01 0.587
R-HSA-111997 CaM pathway 2.587925e-01 0.587
R-HSA-69481 G2/M Checkpoints 2.596724e-01 0.586
R-HSA-4641258 Degradation of DVL 2.639438e-01 0.578
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 2.639438e-01 0.578
R-HSA-5689896 Ovarian tumor domain proteases 2.639438e-01 0.578
R-HSA-71064 Lysine catabolism 2.639438e-01 0.578
R-HSA-8939211 ESR-mediated signaling 2.655667e-01 0.576
R-HSA-6785470 tRNA processing in the mitochondrion 2.690596e-01 0.570
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 2.690596e-01 0.570
R-HSA-9958790 SLC-mediated transport of inorganic anions 2.690596e-01 0.570
R-HSA-8868766 rRNA processing in the mitochondrion 2.791856e-01 0.554
R-HSA-9607240 FLT3 Signaling 2.841964e-01 0.546
R-HSA-3858494 Beta-catenin independent WNT signaling 2.879348e-01 0.541
R-HSA-5655302 Signaling by FGFR1 in disease 2.891726e-01 0.539
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 2.891726e-01 0.539
R-HSA-9609646 HCMV Infection 2.900336e-01 0.538
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 2.941146e-01 0.531
R-HSA-111996 Ca-dependent events 2.941146e-01 0.531
R-HSA-381119 Unfolded Protein Response (UPR) 2.956298e-01 0.529
R-HSA-5654743 Signaling by FGFR4 2.990224e-01 0.524
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 2.990224e-01 0.524
R-HSA-1433557 Signaling by SCF-KIT 2.990224e-01 0.524
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3.038965e-01 0.517
R-HSA-375280 Amine ligand-binding receptors 3.038965e-01 0.517
R-HSA-5683826 Surfactant metabolism 3.038965e-01 0.517
R-HSA-5654741 Signaling by FGFR3 3.087370e-01 0.510
R-HSA-1489509 DAG and IP3 signaling 3.087370e-01 0.510
R-HSA-76009 Platelet Aggregation (Plug Formation) 3.087370e-01 0.510
R-HSA-913531 Interferon Signaling 3.097145e-01 0.509
R-HSA-9675135 Diseases of DNA repair 3.135441e-01 0.504
R-HSA-199977 ER to Golgi Anterograde Transport 3.186361e-01 0.497
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.230592e-01 0.491
R-HSA-9856651 MITF-M-dependent gene expression 3.262698e-01 0.486
R-HSA-9766229 Degradation of CDH1 3.277676e-01 0.484
R-HSA-446652 Interleukin-1 family signaling 3.313470e-01 0.480
R-HSA-5693532 DNA Double-Strand Break Repair 3.338817e-01 0.476
R-HSA-9609507 Protein localization 3.338817e-01 0.476
R-HSA-73887 Death Receptor Signaling 3.364138e-01 0.473
R-HSA-912446 Meiotic recombination 3.370873e-01 0.472
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.416990e-01 0.466
R-HSA-112382 Formation of RNA Pol II elongation complex 3.416990e-01 0.466
R-HSA-6794361 Neurexins and neuroligins 3.416990e-01 0.466
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 3.416990e-01 0.466
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 3.416990e-01 0.466
R-HSA-9634815 Transcriptional Regulation by NPAS4 3.416990e-01 0.466
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 3.462788e-01 0.461
R-HSA-75955 RNA Polymerase II Transcription Elongation 3.462788e-01 0.461
R-HSA-445355 Smooth Muscle Contraction 3.462788e-01 0.461
R-HSA-72649 Translation initiation complex formation 3.508272e-01 0.455
R-HSA-5633007 Regulation of TP53 Activity 3.515455e-01 0.454
R-HSA-1280215 Cytokine Signaling in Immune system 3.520529e-01 0.453
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 3.553441e-01 0.449
R-HSA-418597 G alpha (z) signalling events 3.553441e-01 0.449
R-HSA-109581 Apoptosis 3.565643e-01 0.448
R-HSA-72702 Ribosomal scanning and start codon recognition 3.598299e-01 0.444
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 3.598299e-01 0.444
R-HSA-177929 Signaling by EGFR 3.598299e-01 0.444
R-HSA-5654736 Signaling by FGFR1 3.598299e-01 0.444
R-HSA-9764561 Regulation of CDH1 Function 3.642848e-01 0.439
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 3.642848e-01 0.439
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 3.687089e-01 0.433
R-HSA-9679506 SARS-CoV Infections 3.723770e-01 0.429
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 3.731025e-01 0.428
R-HSA-9033241 Peroxisomal protein import 3.731025e-01 0.428
R-HSA-195721 Signaling by WNT 3.809987e-01 0.419
R-HSA-8939902 Regulation of RUNX2 expression and activity 3.817990e-01 0.418
R-HSA-112043 PLC beta mediated events 3.817990e-01 0.418
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 3.861024e-01 0.413
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 3.861024e-01 0.413
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 3.903760e-01 0.409
R-HSA-380259 Loss of Nlp from mitotic centrosomes 3.903760e-01 0.409
R-HSA-373755 Semaphorin interactions 3.903760e-01 0.409
R-HSA-74751 Insulin receptor signalling cascade 3.946201e-01 0.404
R-HSA-8854518 AURKA Activation by TPX2 4.030208e-01 0.395
R-HSA-5685942 HDR through Homologous Recombination (HRR) 4.071776e-01 0.390
R-HSA-112040 G-protein mediated events 4.071776e-01 0.390
R-HSA-201681 TCF dependent signaling in response to WNT 4.107570e-01 0.386
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 4.113058e-01 0.386
R-HSA-69275 G2/M Transition 4.179821e-01 0.379
R-HSA-195253 Degradation of beta-catenin by the destruction complex 4.194769e-01 0.377
R-HSA-204005 COPII-mediated vesicle transport 4.194769e-01 0.377
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 4.194769e-01 0.377
R-HSA-1852241 Organelle biogenesis and maintenance 4.220813e-01 0.375
R-HSA-453274 Mitotic G2-G2/M phases 4.227744e-01 0.374
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 4.235203e-01 0.373
R-HSA-453276 Regulation of mitotic cell cycle 4.235203e-01 0.373
R-HSA-5620920 Cargo trafficking to the periciliary membrane 4.235203e-01 0.373
R-HSA-199992 trans-Golgi Network Vesicle Budding 4.275356e-01 0.369
R-HSA-5617833 Cilium Assembly 4.275468e-01 0.369
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 4.315233e-01 0.365
R-HSA-4086398 Ca2+ pathway 4.315233e-01 0.365
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 4.315233e-01 0.365
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 4.322988e-01 0.364
R-HSA-674695 RNA Polymerase II Pre-transcription Events 4.354834e-01 0.361
R-HSA-69473 G2/M DNA damage checkpoint 4.354834e-01 0.361
R-HSA-1226099 Signaling by FGFR in disease 4.354834e-01 0.361
R-HSA-380287 Centrosome maturation 4.394162e-01 0.357
R-HSA-8852135 Protein ubiquitination 4.394162e-01 0.357
R-HSA-5689603 UCH proteinases 4.433219e-01 0.353
R-HSA-4086400 PCP/CE pathway 4.510524e-01 0.346
R-HSA-948021 Transport to the Golgi and subsequent modification 4.557417e-01 0.341
R-HSA-5654738 Signaling by FGFR2 4.586766e-01 0.338
R-HSA-6806834 Signaling by MET 4.586766e-01 0.338
R-HSA-5693607 Processing of DNA double-strand break ends 4.624492e-01 0.335
R-HSA-5357801 Programmed Cell Death 4.649652e-01 0.333
R-HSA-449147 Signaling by Interleukins 4.684935e-01 0.329
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.736114e-01 0.325
R-HSA-390918 Peroxisomal lipid metabolism 4.736114e-01 0.325
R-HSA-6794362 Protein-protein interactions at synapses 4.772809e-01 0.321
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 4.808858e-01 0.318
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 4.809250e-01 0.318
R-HSA-9730414 MITF-M-regulated melanocyte development 4.831368e-01 0.316
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 4.845439e-01 0.315
R-HSA-390466 Chaperonin-mediated protein folding 4.881378e-01 0.311
R-HSA-9645723 Diseases of programmed cell death 4.917069e-01 0.308
R-HSA-9663891 Selective autophagy 4.917069e-01 0.308
R-HSA-73894 DNA Repair 4.942151e-01 0.306
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 4.987712e-01 0.302
R-HSA-9006931 Signaling by Nuclear Receptors 4.994547e-01 0.302
R-HSA-597592 Post-translational protein modification 5.063384e-01 0.296
R-HSA-1266738 Developmental Biology 5.069876e-01 0.295
R-HSA-74752 Signaling by Insulin receptor 5.091857e-01 0.293
R-HSA-391251 Protein folding 5.091857e-01 0.293
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 5.260686e-01 0.279
R-HSA-6807878 COPI-mediated anterograde transport 5.260686e-01 0.279
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.260686e-01 0.279
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.293755e-01 0.276
R-HSA-190236 Signaling by FGFR 5.326595e-01 0.274
R-HSA-422356 Regulation of insulin secretion 5.326595e-01 0.274
R-HSA-3214847 HATs acetylate histones 5.359207e-01 0.271
R-HSA-9614085 FOXO-mediated transcription 5.359207e-01 0.271
R-HSA-1483255 PI Metabolism 5.455699e-01 0.263
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 5.518919e-01 0.258
R-HSA-111885 Opioid Signalling 5.518919e-01 0.258
R-HSA-9692914 SARS-CoV-1-host interactions 5.612118e-01 0.251
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 5.642755e-01 0.249
R-HSA-9700206 Signaling by ALK in cancer 5.642755e-01 0.249
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 5.673181e-01 0.246
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 5.673181e-01 0.246
R-HSA-418594 G alpha (i) signalling events 5.745731e-01 0.241
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 5.851362e-01 0.233
R-HSA-2262752 Cellular responses to stress 5.893718e-01 0.230
R-HSA-5628897 TP53 Regulates Metabolic Genes 5.909124e-01 0.228
R-HSA-2871809 FCERI mediated Ca+2 mobilization 5.937706e-01 0.226
R-HSA-72613 Eukaryotic Translation Initiation 5.966090e-01 0.224
R-HSA-72737 Cap-dependent Translation Initiation 5.966090e-01 0.224
R-HSA-1592230 Mitochondrial biogenesis 5.994277e-01 0.222
R-HSA-5693538 Homology Directed Repair 6.022268e-01 0.220
R-HSA-8878166 Transcriptional regulation by RUNX2 6.050066e-01 0.218
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 6.159346e-01 0.210
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 6.231857e-01 0.205
R-HSA-199418 Negative regulation of the PI3K/AKT network 6.368995e-01 0.196
R-HSA-8856688 Golgi-to-ER retrograde transport 6.444655e-01 0.191
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 6.466490e-01 0.189
R-HSA-388396 GPCR downstream signalling 6.530424e-01 0.185
R-HSA-163685 Integration of energy metabolism 6.567297e-01 0.183
R-HSA-112316 Neuronal System 6.646388e-01 0.177
R-HSA-1632852 Macroautophagy 6.685746e-01 0.175
R-HSA-8856828 Clathrin-mediated endocytosis 6.754861e-01 0.170
R-HSA-1500931 Cell-Cell communication 6.807589e-01 0.167
R-HSA-199991 Membrane Trafficking 6.884792e-01 0.162
R-HSA-9758941 Gastrulation 6.888834e-01 0.162
R-HSA-9679191 Potential therapeutics for SARS 6.910624e-01 0.160
R-HSA-112315 Transmission across Chemical Synapses 6.916913e-01 0.160
R-HSA-9755511 KEAP1-NFE2L2 pathway 6.932262e-01 0.159
R-HSA-9612973 Autophagy 7.038222e-01 0.153
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 7.079582e-01 0.150
R-HSA-8953897 Cellular responses to stimuli 7.092897e-01 0.149
R-HSA-9006936 Signaling by TGFB family members 7.120371e-01 0.147
R-HSA-9006925 Intracellular signaling by second messengers 7.198315e-01 0.143
R-HSA-5621481 C-type lectin receptors (CLRs) 7.353510e-01 0.134
R-HSA-372790 Signaling by GPCR 7.365882e-01 0.133
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.372072e-01 0.132
R-HSA-5689880 Ub-specific processing proteases 7.390505e-01 0.131
R-HSA-9764265 Regulation of CDH1 Expression and Function 7.390505e-01 0.131
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 7.390505e-01 0.131
R-HSA-9678108 SARS-CoV-1 Infection 7.426987e-01 0.129
R-HSA-375276 Peptide ligand-binding receptors 7.618786e-01 0.118
R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.744814e-01 0.111
R-HSA-72163 mRNA Splicing - Major Pathway 7.749310e-01 0.111
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 7.780817e-01 0.109
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 7.842526e-01 0.106
R-HSA-389948 Co-inhibition by PD-1 7.842526e-01 0.106
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 7.871824e-01 0.104
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 7.887689e-01 0.103
R-HSA-72172 mRNA Splicing 7.917275e-01 0.101
R-HSA-397014 Muscle contraction 8.031571e-01 0.095
R-HSA-418990 Adherens junctions interactions 8.113192e-01 0.091
R-HSA-392499 Metabolism of proteins 8.139169e-01 0.089
R-HSA-446203 Asparagine N-linked glycosylation 8.167357e-01 0.088
R-HSA-72312 rRNA processing 8.290828e-01 0.081
R-HSA-3247509 Chromatin modifying enzymes 8.314813e-01 0.080
R-HSA-5653656 Vesicle-mediated transport 8.339054e-01 0.079
R-HSA-4839726 Chromatin organization 8.484378e-01 0.071
R-HSA-421270 Cell-cell junction organization 8.505669e-01 0.070
R-HSA-388841 Regulation of T cell activation by CD28 family 8.557610e-01 0.068
R-HSA-416476 G alpha (q) signalling events 8.637018e-01 0.064
R-HSA-9711123 Cellular response to chemical stress 8.675081e-01 0.062
R-HSA-76002 Platelet activation, signaling and aggregation 8.730210e-01 0.059
R-HSA-446728 Cell junction organization 8.765693e-01 0.057
R-HSA-9824443 Parasitic Infection Pathways 8.791659e-01 0.056
R-HSA-9658195 Leishmania infection 8.791659e-01 0.056
R-HSA-1257604 PIP3 activates AKT signaling 8.905851e-01 0.050
R-HSA-1483257 Phospholipid metabolism 8.905851e-01 0.050
R-HSA-9824446 Viral Infection Pathways 9.077869e-01 0.042
R-HSA-500792 GPCR ligand binding 9.284197e-01 0.032
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 9.378203e-01 0.028
R-HSA-71291 Metabolism of amino acids and derivatives 9.396270e-01 0.027
R-HSA-1280218 Adaptive Immune System 9.436957e-01 0.025
R-HSA-9824439 Bacterial Infection Pathways 9.447403e-01 0.025
R-HSA-1643685 Disease 9.473210e-01 0.024
R-HSA-425407 SLC-mediated transmembrane transport 9.474339e-01 0.023
R-HSA-8978868 Fatty acid metabolism 9.510577e-01 0.022
R-HSA-72766 Translation 9.581815e-01 0.019
R-HSA-5663205 Infectious disease 9.600884e-01 0.018
R-HSA-168256 Immune System 9.637393e-01 0.016
R-HSA-422475 Axon guidance 9.818213e-01 0.008
R-HSA-9675108 Nervous system development 9.860816e-01 0.006
R-HSA-109582 Hemostasis 9.967973e-01 0.001
R-HSA-382551 Transport of small molecules 9.992500e-01 0.000
R-HSA-556833 Metabolism of lipids 9.997941e-01 0.000
R-HSA-168249 Innate Immune System 9.999449e-01 0.000
R-HSA-1430728 Metabolism 9.999947e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GRK1GRK1 0.817 0.357 -2 0.862
BMPR1BBMPR1B 0.807 0.333 1 0.749
COTCOT 0.807 0.222 2 0.870
MOSMOS 0.805 0.314 1 0.629
CDC7CDC7 0.804 0.167 1 0.664
GRK6GRK6 0.797 0.232 1 0.651
KISKIS 0.796 0.097 1 0.455
IKKBIKKB 0.795 0.063 -2 0.778
GRK5GRK5 0.793 0.151 -3 0.873
BMPR1ABMPR1A 0.793 0.272 1 0.726
GRK7GRK7 0.793 0.200 1 0.595
IKKAIKKA 0.791 0.091 -2 0.767
CK2A2CK2A2 0.791 0.240 1 0.672
ACVR2BACVR2B 0.789 0.284 -2 0.787
CLK3CLK3 0.788 0.054 1 0.565
TGFBR1TGFBR1 0.787 0.196 -2 0.799
GRK4GRK4 0.786 0.115 -2 0.863
GRK2GRK2 0.786 0.249 -2 0.752
DSTYKDSTYK 0.786 0.046 2 0.885
PIM3PIM3 0.783 0.023 -3 0.800
CAMK2GCAMK2G 0.783 0.042 2 0.817
ACVR2AACVR2A 0.783 0.235 -2 0.768
MTORMTOR 0.783 -0.080 1 0.507
GRK3GRK3 0.783 0.236 -2 0.719
PRPKPRPK 0.782 -0.047 -1 0.550
CK2A1CK2A1 0.782 0.234 1 0.671
RAF1RAF1 0.781 -0.024 1 0.561
GCN2GCN2 0.780 -0.072 2 0.815
IKKEIKKE 0.778 -0.080 1 0.447
TBK1TBK1 0.777 -0.106 1 0.448
ALK2ALK2 0.777 0.154 -2 0.819
BMPR2BMPR2 0.777 -0.041 -2 0.867
FAM20CFAM20C 0.776 0.072 2 0.650
NLKNLK 0.776 -0.014 1 0.558
ERK5ERK5 0.775 -0.044 1 0.519
NDR2NDR2 0.775 -0.028 -3 0.790
PDHK4PDHK4 0.774 -0.197 1 0.548
ALK4ALK4 0.774 0.122 -2 0.824
CAMK1BCAMK1B 0.774 -0.022 -3 0.816
MLK1MLK1 0.774 0.003 2 0.828
HUNKHUNK 0.773 -0.006 2 0.845
PLK1PLK1 0.772 0.106 -2 0.771
CK1ECK1E 0.772 0.145 -3 0.610
DLKDLK 0.772 0.078 1 0.568
SKMLCKSKMLCK 0.772 0.026 -2 0.829
CDKL1CDKL1 0.771 -0.007 -3 0.778
ATRATR 0.771 -0.068 1 0.499
RSK2RSK2 0.770 0.016 -3 0.724
HIPK4HIPK4 0.770 -0.014 1 0.516
CDK1CDK1 0.770 0.022 1 0.493
RIPK3RIPK3 0.769 -0.028 3 0.634
TGFBR2TGFBR2 0.769 -0.016 -2 0.775
CDK8CDK8 0.769 -0.022 1 0.459
BCKDKBCKDK 0.768 -0.105 -1 0.515
CHAK2CHAK2 0.768 -0.044 -1 0.567
PKN3PKN3 0.767 -0.038 -3 0.781
JNK3JNK3 0.767 0.018 1 0.462
NEK6NEK6 0.767 -0.091 -2 0.828
NEK7NEK7 0.767 -0.109 -3 0.786
DYRK2DYRK2 0.767 -0.001 1 0.484
SRPK1SRPK1 0.766 -0.002 -3 0.727
ULK2ULK2 0.766 -0.166 2 0.802
CAMK2BCAMK2B 0.766 0.028 2 0.785
DRAK1DRAK1 0.766 0.176 1 0.696
ATMATM 0.765 -0.047 1 0.464
JNK2JNK2 0.765 0.017 1 0.449
PDHK1PDHK1 0.765 -0.228 1 0.508
MST4MST4 0.765 -0.047 2 0.849
CK1DCK1D 0.765 0.143 -3 0.559
MLK3MLK3 0.764 0.002 2 0.763
P38GP38G 0.764 0.013 1 0.415
DAPK2DAPK2 0.764 -0.013 -3 0.817
PIM1PIM1 0.764 -0.016 -3 0.744
TTBK2TTBK2 0.764 -0.060 2 0.722
CAMLCKCAMLCK 0.763 -0.047 -2 0.815
NIKNIK 0.763 -0.117 -3 0.831
PKN2PKN2 0.763 -0.029 -3 0.787
NDR1NDR1 0.763 -0.065 -3 0.782
CDK19CDK19 0.762 -0.025 1 0.437
MAPKAPK2MAPKAPK2 0.762 0.004 -3 0.669
ANKRD3ANKRD3 0.762 -0.042 1 0.539
CDKL5CDKL5 0.761 -0.035 -3 0.761
HIPK2HIPK2 0.761 0.017 1 0.434
CDK18CDK18 0.761 -0.007 1 0.435
PRKD1PRKD1 0.761 -0.080 -3 0.748
NUAK2NUAK2 0.761 -0.055 -3 0.779
MLK4MLK4 0.761 0.020 2 0.740
ULK1ULK1 0.761 -0.130 -3 0.756
LATS1LATS1 0.760 0.013 -3 0.801
PASKPASK 0.760 0.138 -3 0.819
RIPK1RIPK1 0.760 -0.109 1 0.503
P90RSKP90RSK 0.760 -0.034 -3 0.728
WNK1WNK1 0.759 -0.114 -2 0.863
P70S6KBP70S6KB 0.759 -0.034 -3 0.744
CK1A2CK1A2 0.759 0.135 -3 0.560
PLK3PLK3 0.759 -0.007 2 0.777
ICKICK 0.759 -0.044 -3 0.794
MEK1MEK1 0.759 0.005 2 0.856
MASTLMASTL 0.758 -0.157 -2 0.817
RSK4RSK4 0.758 0.027 -3 0.696
CAMK2ACAMK2A 0.758 0.009 2 0.799
CDK13CDK13 0.758 -0.037 1 0.455
ERK1ERK1 0.758 -0.011 1 0.428
P38BP38B 0.758 -0.003 1 0.437
CDK5CDK5 0.758 -0.009 1 0.491
RSK3RSK3 0.757 -0.050 -3 0.727
P38DP38D 0.757 0.016 1 0.373
CDK7CDK7 0.757 -0.045 1 0.476
CAMK2DCAMK2D 0.757 -0.094 -3 0.767
LATS2LATS2 0.757 -0.071 -5 0.648
PKRPKR 0.757 -0.059 1 0.517
CDK17CDK17 0.757 -0.010 1 0.423
PKACGPKACG 0.756 -0.051 -2 0.711
SRPK3SRPK3 0.756 -0.002 -3 0.718
TLK2TLK2 0.756 -0.057 1 0.489
YSK4YSK4 0.756 -0.061 1 0.491
MEKK3MEKK3 0.756 0.055 1 0.524
PRP4PRP4 0.755 0.029 -3 0.766
PRKD2PRKD2 0.755 -0.058 -3 0.684
SRPK2SRPK2 0.755 -0.014 -3 0.652
MLK2MLK2 0.755 -0.126 2 0.825
MARK4MARK4 0.754 -0.104 4 0.807
CLK2CLK2 0.754 0.037 -3 0.709
HIPK1HIPK1 0.754 -0.000 1 0.488
DYRK4DYRK4 0.754 0.004 1 0.448
AURCAURC 0.753 -0.026 -2 0.605
WNK3WNK3 0.753 -0.219 1 0.481
JNK1JNK1 0.753 0.019 1 0.463
PKCDPKCD 0.753 -0.080 2 0.802
MAPKAPK3MAPKAPK3 0.753 -0.076 -3 0.701
PLK2PLK2 0.753 0.081 -3 0.844
ERK2ERK2 0.752 -0.028 1 0.450
IRE1IRE1 0.752 -0.118 1 0.470
CDK12CDK12 0.751 -0.037 1 0.436
P38AP38A 0.751 -0.035 1 0.474
TSSK2TSSK2 0.751 -0.085 -5 0.720
MSK2MSK2 0.751 -0.050 -3 0.712
AMPKA1AMPKA1 0.751 -0.107 -3 0.787
MSK1MSK1 0.751 -0.009 -3 0.714
GAKGAK 0.750 0.098 1 0.580
NEK9NEK9 0.750 -0.208 2 0.843
CDK2CDK2 0.749 -0.045 1 0.547
PRKXPRKX 0.749 0.017 -3 0.633
PAK1PAK1 0.749 -0.080 -2 0.739
VRK2VRK2 0.749 -0.187 1 0.541
MYLK4MYLK4 0.749 -0.008 -2 0.735
AURAAURA 0.748 -0.015 -2 0.565
CK1G1CK1G1 0.748 0.023 -3 0.625
BRAFBRAF 0.748 -0.049 -4 0.747
DYRK1BDYRK1B 0.747 -0.011 1 0.473
CAMK4CAMK4 0.747 -0.115 -3 0.755
PKACBPKACB 0.747 -0.018 -2 0.620
CDK3CDK3 0.747 -0.020 1 0.437
CDK9CDK9 0.746 -0.056 1 0.453
CLK4CLK4 0.746 -0.032 -3 0.724
CDK16CDK16 0.746 -0.012 1 0.426
GSK3AGSK3A 0.746 0.041 4 0.509
NIM1NIM1 0.746 -0.148 3 0.719
PKCGPKCG 0.744 -0.071 2 0.759
CDK14CDK14 0.744 -0.023 1 0.470
CK1ACK1A 0.744 0.160 -3 0.485
DYRK1ADYRK1A 0.744 -0.028 1 0.482
SMG1SMG1 0.744 -0.137 1 0.438
PKCBPKCB 0.744 -0.067 2 0.754
TLK1TLK1 0.743 -0.085 -2 0.816
AMPKA2AMPKA2 0.743 -0.106 -3 0.752
PERKPERK 0.743 -0.133 -2 0.842
ZAKZAK 0.743 -0.096 1 0.482
DNAPKDNAPK 0.742 -0.118 1 0.379
TAO3TAO3 0.741 -0.042 1 0.508
TSSK1TSSK1 0.741 -0.124 -3 0.798
MST3MST3 0.741 -0.007 2 0.841
PKCAPKCA 0.741 -0.082 2 0.750
MEKK2MEKK2 0.740 -0.078 2 0.817
GSK3BGSK3B 0.740 0.014 4 0.503
TAK1TAK1 0.740 0.055 1 0.543
PAK3PAK3 0.740 -0.137 -2 0.737
PRKD3PRKD3 0.740 -0.081 -3 0.683
PLK4PLK4 0.740 -0.117 2 0.673
SGK3SGK3 0.740 -0.058 -3 0.723
MEKK1MEKK1 0.739 -0.142 1 0.478
BRSK1BRSK1 0.739 -0.050 -3 0.731
AURBAURB 0.739 -0.057 -2 0.600
PIM2PIM2 0.739 -0.040 -3 0.698
PAK2PAK2 0.739 -0.112 -2 0.729
MEK5MEK5 0.739 -0.143 2 0.833
IRE2IRE2 0.739 -0.150 2 0.769
CLK1CLK1 0.739 -0.047 -3 0.688
QSKQSK 0.739 -0.089 4 0.778
PINK1PINK1 0.738 -0.163 1 0.542
CDK10CDK10 0.738 -0.015 1 0.465
MARK3MARK3 0.738 -0.059 4 0.726
HIPK3HIPK3 0.738 -0.051 1 0.458
DYRK3DYRK3 0.737 -0.033 1 0.481
QIKQIK 0.737 -0.141 -3 0.768
AKT2AKT2 0.737 -0.034 -3 0.644
CHAK1CHAK1 0.737 -0.179 2 0.770
MPSK1MPSK1 0.737 -0.058 1 0.506
MST2MST2 0.737 -0.004 1 0.530
PKCHPKCH 0.737 -0.100 2 0.750
PKCZPKCZ 0.737 -0.130 2 0.791
NEK2NEK2 0.736 -0.202 2 0.822
MARK2MARK2 0.736 -0.073 4 0.699
PKG2PKG2 0.736 -0.058 -2 0.633
MELKMELK 0.735 -0.139 -3 0.728
TTBK1TTBK1 0.735 -0.116 2 0.645
NUAK1NUAK1 0.735 -0.122 -3 0.724
CAMK1GCAMK1G 0.734 -0.062 -3 0.700
CHK1CHK1 0.734 -0.139 -3 0.754
PAK6PAK6 0.734 -0.089 -2 0.657
GCKGCK 0.734 0.002 1 0.564
MARK1MARK1 0.733 -0.066 4 0.750
MNK2MNK2 0.733 -0.136 -2 0.737
CAMKK1CAMKK1 0.733 -0.120 -2 0.782
HRIHRI 0.733 -0.219 -2 0.828
DAPK1DAPK1 0.733 0.037 -3 0.737
NEK11NEK11 0.733 -0.077 1 0.522
SIKSIK 0.732 -0.105 -3 0.698
PHKG1PHKG1 0.732 -0.142 -3 0.757
BMPR2_TYRBMPR2_TYR 0.731 0.398 -1 0.664
MAPKAPK5MAPKAPK5 0.731 -0.123 -3 0.669
MNK1MNK1 0.731 -0.125 -2 0.754
NEK8NEK8 0.731 -0.118 2 0.828
NEK5NEK5 0.730 -0.192 1 0.490
SMMLCKSMMLCK 0.730 -0.057 -3 0.772
WNK4WNK4 0.730 -0.184 -2 0.855
DAPK3DAPK3 0.729 -0.012 -3 0.743
P70S6KP70S6K 0.729 -0.066 -3 0.662
PDK1PDK1 0.728 -0.105 1 0.496
ERK7ERK7 0.728 -0.027 2 0.562
DCAMKL1DCAMKL1 0.728 -0.114 -3 0.713
HPK1HPK1 0.727 -0.026 1 0.543
ALPHAK3ALPHAK3 0.727 0.054 -1 0.542
SNRKSNRK 0.727 -0.172 2 0.703
PKACAPKACA 0.726 -0.041 -2 0.567
MINKMINK 0.726 -0.080 1 0.489
PTK2PTK2 0.726 0.378 -1 0.736
IRAK1IRAK1 0.726 -0.185 -1 0.479
BRSK2BRSK2 0.726 -0.150 -3 0.740
MAKMAK 0.725 -0.003 -2 0.728
CDK4CDK4 0.725 -0.047 1 0.427
CDK6CDK6 0.725 -0.048 1 0.438
PDHK3_TYRPDHK3_TYR 0.725 0.159 4 0.909
CAMKK2CAMKK2 0.725 -0.150 -2 0.773
TAO2TAO2 0.724 -0.137 2 0.854
IRAK4IRAK4 0.724 -0.196 1 0.444
LKB1LKB1 0.724 -0.152 -3 0.763
VRK1VRK1 0.723 -0.091 2 0.853
TXKTXK 0.723 0.289 1 0.666
PDHK1_TYRPDHK1_TYR 0.723 0.236 -1 0.625
SSTKSSTK 0.722 -0.105 4 0.766
AKT1AKT1 0.722 -0.061 -3 0.651
SYKSYK 0.722 0.346 -1 0.681
MAP2K6_TYRMAP2K6_TYR 0.722 0.204 -1 0.590
EEF2KEEF2K 0.722 -0.090 3 0.700
MST1MST1 0.721 -0.088 1 0.495
DCAMKL2DCAMKL2 0.720 -0.120 -3 0.727
PKCTPKCT 0.720 -0.130 2 0.753
PDHK4_TYRPDHK4_TYR 0.720 0.170 2 0.861
TNIKTNIK 0.719 -0.113 3 0.748
OSR1OSR1 0.719 0.001 2 0.812
CAMK1DCAMK1D 0.718 -0.076 -3 0.624
LRRK2LRRK2 0.718 -0.174 2 0.855
MAP3K15MAP3K15 0.718 -0.157 1 0.457
EPHA6EPHA6 0.718 0.197 -1 0.662
PKCIPKCI 0.717 -0.120 2 0.766
SGK1SGK1 0.717 -0.029 -3 0.582
SLKSLK 0.717 -0.094 -2 0.708
KHS2KHS2 0.716 -0.055 1 0.516
HGKHGK 0.716 -0.154 3 0.741
PKCEPKCE 0.715 -0.075 2 0.749
MOKMOK 0.715 -0.039 1 0.481
MAP2K4_TYRMAP2K4_TYR 0.715 0.044 -1 0.562
MEKK6MEKK6 0.714 -0.181 1 0.467
PAK5PAK5 0.714 -0.112 -2 0.582
PBKPBK 0.714 -0.082 1 0.488
ROCK2ROCK2 0.714 -0.057 -3 0.736
PHKG2PHKG2 0.714 -0.159 -3 0.724
AKT3AKT3 0.713 -0.039 -3 0.587
KHS1KHS1 0.713 -0.110 1 0.481
FYNFYN 0.712 0.248 -1 0.644
PAK4PAK4 0.712 -0.097 -2 0.582
NEK4NEK4 0.711 -0.243 1 0.453
EPHB4EPHB4 0.711 0.105 -1 0.593
STK33STK33 0.711 -0.142 2 0.644
TTKTTK 0.710 -0.037 -2 0.795
LOKLOK 0.710 -0.160 -2 0.751
MEK2MEK2 0.710 -0.209 2 0.822
TESK1_TYRTESK1_TYR 0.710 -0.038 3 0.791
CHK2CHK2 0.710 -0.060 -3 0.583
RIPK2RIPK2 0.709 -0.196 1 0.444
CK1G2CK1G2 0.709 0.134 -3 0.539
MRCKBMRCKB 0.709 -0.075 -3 0.686
YANK3YANK3 0.708 -0.024 2 0.416
CK1G3CK1G3 0.708 0.065 -3 0.447
EPHA4EPHA4 0.708 0.116 2 0.780
MRCKAMRCKA 0.707 -0.087 -3 0.700
PKN1PKN1 0.707 -0.100 -3 0.663
EPHB2EPHB2 0.707 0.125 -1 0.592
MAP2K7_TYRMAP2K7_TYR 0.707 -0.112 2 0.861
LCKLCK 0.706 0.161 -1 0.626
PINK1_TYRPINK1_TYR 0.706 -0.044 1 0.549
NEK1NEK1 0.706 -0.251 1 0.460
YSK1YSK1 0.706 -0.158 2 0.813
PKMYT1_TYRPKMYT1_TYR 0.706 -0.086 3 0.752
SRMSSRMS 0.706 0.115 1 0.621
BUB1BUB1 0.705 -0.080 -5 0.665
HASPINHASPIN 0.705 -0.087 -1 0.422
FERFER 0.704 0.042 1 0.599
INSRRINSRR 0.703 0.085 3 0.654
BLKBLK 0.703 0.144 -1 0.625
EPHB1EPHB1 0.703 0.101 1 0.590
BIKEBIKE 0.703 -0.058 1 0.494
SBKSBK 0.703 -0.055 -3 0.517
ITKITK 0.702 0.128 -1 0.547
YES1YES1 0.701 0.020 -1 0.548
BMXBMX 0.701 0.104 -1 0.494
DMPK1DMPK1 0.701 -0.057 -3 0.703
CAMK1ACAMK1A 0.700 -0.090 -3 0.602
ABL2ABL2 0.700 -0.008 -1 0.517
EPHB3EPHB3 0.700 0.056 -1 0.586
HCKHCK 0.700 0.090 -1 0.598
FGRFGR 0.700 0.018 1 0.568
FLT1FLT1 0.698 0.094 -1 0.642
ASK1ASK1 0.698 -0.162 1 0.453
JAK3JAK3 0.698 0.014 1 0.468
METMET 0.697 0.073 3 0.679
EPHA8EPHA8 0.697 0.132 -1 0.633
ABL1ABL1 0.696 -0.036 -1 0.503
RETRET 0.696 -0.159 1 0.465
MYO3AMYO3A 0.696 -0.119 1 0.472
EGFREGFR 0.696 0.047 1 0.445
CRIKCRIK 0.695 -0.060 -3 0.653
ROCK1ROCK1 0.695 -0.081 -3 0.700
EPHA7EPHA7 0.695 0.078 2 0.786
STLK3STLK3 0.695 -0.100 1 0.448
LIMK2_TYRLIMK2_TYR 0.695 -0.159 -3 0.822
CSF1RCSF1R 0.694 -0.070 3 0.674
SRCSRC 0.693 0.102 -1 0.584
EPHA5EPHA5 0.693 0.081 2 0.768
KITKIT 0.693 -0.026 3 0.671
MST1RMST1R 0.693 -0.135 3 0.701
ERBB4ERBB4 0.693 0.136 1 0.521
ZAP70ZAP70 0.693 0.146 -1 0.600
FGFR2FGFR2 0.691 -0.073 3 0.705
ERBB2ERBB2 0.691 0.016 1 0.501
TECTEC 0.691 0.012 -1 0.458
LIMK1_TYRLIMK1_TYR 0.691 -0.206 2 0.859
EPHA2EPHA2 0.691 0.134 -1 0.618
NEK3NEK3 0.691 -0.262 1 0.401
MYO3BMYO3B 0.691 -0.155 2 0.824
TYRO3TYRO3 0.691 -0.127 3 0.683
MERTKMERTK 0.691 -0.010 3 0.681
PKG1PKG1 0.690 -0.099 -2 0.543
EPHA3EPHA3 0.689 0.022 2 0.754
PTK2BPTK2B 0.689 0.068 -1 0.482
JAK2JAK2 0.688 -0.177 1 0.444
ROS1ROS1 0.688 -0.142 3 0.659
TAO1TAO1 0.688 -0.179 1 0.415
FRKFRK 0.688 0.033 -1 0.590
FGFR4FGFR4 0.687 -0.003 -1 0.525
FGFR3FGFR3 0.687 -0.025 3 0.673
DDR1DDR1 0.687 -0.185 4 0.832
TYK2TYK2 0.686 -0.251 1 0.455
LYNLYN 0.686 0.043 3 0.585
NTRK1NTRK1 0.685 -0.066 -1 0.534
KDRKDR 0.685 -0.057 3 0.632
FLT3FLT3 0.683 -0.124 3 0.669
AAK1AAK1 0.683 -0.051 1 0.422
NTRK3NTRK3 0.683 -0.045 -1 0.501
WEE1_TYRWEE1_TYR 0.683 -0.076 -1 0.475
MATKMATK 0.683 -0.043 -1 0.475
INSRINSR 0.682 -0.041 3 0.630
BTKBTK 0.681 -0.099 -1 0.476
PDGFRBPDGFRB 0.681 -0.161 3 0.677
YANK2YANK2 0.680 -0.024 2 0.436
AXLAXL 0.680 -0.134 3 0.675
PTK6PTK6 0.680 -0.151 -1 0.443
FGFR1FGFR1 0.680 -0.160 3 0.660
TNK2TNK2 0.680 -0.146 3 0.642
TEKTEK 0.678 -0.124 3 0.621
IGF1RIGF1R 0.678 0.020 3 0.577
EPHA1EPHA1 0.676 -0.072 3 0.649
ALKALK 0.676 -0.121 3 0.602
FLT4FLT4 0.676 -0.101 3 0.631
CSKCSK 0.676 -0.064 2 0.785
NTRK2NTRK2 0.676 -0.121 3 0.641
NEK10_TYRNEK10_TYR 0.674 -0.212 1 0.388
LTKLTK 0.674 -0.147 3 0.619
JAK1JAK1 0.673 -0.171 1 0.417
FESFES 0.670 0.033 -1 0.467
PDGFRAPDGFRA 0.668 -0.256 3 0.669
TNNI3K_TYRTNNI3K_TYR 0.667 -0.224 1 0.433
TNK1TNK1 0.667 -0.246 3 0.676
DDR2DDR2 0.666 -0.130 3 0.625
MUSKMUSK 0.664 -0.091 1 0.436