Motif 408 (n=124)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0B4J269 None Y687 ochoa Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}.
A7E2V4 ZSWIM8 S559 ochoa Zinc finger SWIM domain-containing protein 8 Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}.
B2RUZ4 SMIM1 S28 ochoa Small integral membrane protein 1 (Vel blood group antigen) Regulator of red blood cell formation. {ECO:0000250|UniProtKB:B3DHH5}.
O15014 ZNF609 S778 ochoa Zinc finger protein 609 Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}.
O43166 SIPA1L1 S1366 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43237 DYNC1LI2 S407 ochoa Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}.
O60759 CYTIP S66 ochoa Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
O75122 CLASP2 S360 ochoa CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
O75179 ANKRD17 S1567 ochoa Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.
O75475 PSIP1 S443 ochoa PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}.
O76061 STC2 S251 ochoa Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
O94759 TRPM2 S39 psp Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2) [Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:12594222, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27068538, PubMed:27383051, PubMed:28775320, PubMed:29745897, PubMed:30467180, PubMed:31513012, PubMed:34788616). Functions as a ligand-gated ion channel, gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular Ca(2+) passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro) (PubMed:22493272). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606). {ECO:0000250|UniProtKB:Q91YD4, ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734, ECO:0000269|PubMed:11804595, ECO:0000269|PubMed:11960981, ECO:0000269|PubMed:12594222, ECO:0000269|PubMed:15561722, ECO:0000269|PubMed:16601673, ECO:0000269|PubMed:19171771, ECO:0000269|PubMed:19454650, ECO:0000269|PubMed:20650899, ECO:0000269|PubMed:20660597, ECO:0000269|PubMed:22493272, ECO:0000269|PubMed:25562606, ECO:0000269|PubMed:25620041, ECO:0000269|PubMed:25918360, ECO:0000269|PubMed:27068538, ECO:0000269|PubMed:27383051, ECO:0000269|PubMed:28775320, ECO:0000269|PubMed:29745897, ECO:0000269|PubMed:30467180, ECO:0000269|PubMed:31513012, ECO:0000269|PubMed:34788616}.; FUNCTION: [Isoform 2]: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose. {ECO:0000269|PubMed:11960981}.; FUNCTION: [Isoform 3]: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress. {ECO:0000269|PubMed:12594222}.
O94888 UBXN7 S270 ochoa UBX domain-containing protein 7 Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}.
P04350 TUBB4A Y340 ochoa Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P05165 PCCA S252 ochoa Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:8434582). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:10101253, PubMed:6765947, PubMed:8434582). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). {ECO:0000250|UniProtKB:P0DTA4, ECO:0000250|UniProtKB:Q5LUF3, ECO:0000269|PubMed:10101253, ECO:0000269|PubMed:6765947, ECO:0000269|PubMed:8434582}.
P05549 TFAP2A T224 ochoa Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}.
P07437 TUBB Y340 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P11055 MYH3 S644 ochoa Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) Muscle contraction.
P12268 IMPDH2 S426 ochoa Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}.
P12882 MYH1 S647 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S643 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 S645 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 S646 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P17661 DES S47 ochoa Desmin Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}.
P28715 ERCC5 S1069 ochoa DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}.
P42566 EPS15 S607 ochoa Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
P49790 NUP153 S938 ochoa Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
P49916 LIG3 S854 ochoa DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.
P54259 ATN1 S42 ochoa Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
P54296 MYOM2 S1274 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P55201 BRPF1 S867 ochoa Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}.
P63241 EIF5A S46 ochoa Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}.
P68371 TUBB4B Y340 ochoa Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P98171 ARHGAP4 S217 ochoa Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Q01831 XPC S399 ochoa DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}.
Q08945 SSRP1 S673 ochoa FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}.
Q09666 AHNAK S177 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S282 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12802 AKAP13 S1619 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q12888 TP53BP1 S1311 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13422 IKZF1 S215 psp DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}.
Q13509 TUBB3 Y340 ochoa|psp Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
Q13561 DCTN2 S203 ochoa Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}.
Q13625 TP53BP2 S683 ochoa Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q13772 NCOA4 S554 ochoa Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}.
Q13885 TUBB2A Y340 ochoa Tubulin beta-2A chain (Tubulin beta class IIa) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q14151 SAFB2 S195 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14247 CTTN S282 ochoa Src substrate cortactin (Amplaxin) (Oncogene EMS1) Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}.
Q14766 LTBP1 S1415 ochoa Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}.
Q15283 RASA2 S560 ochoa Ras GTPase-activating protein 2 (GTPase-activating protein 1m) (GAP1m) Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
Q15365 PCBP1 S264 ochoa Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.
Q15366 PCBP2 S272 ochoa|psp Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}.
Q2M1Z3 ARHGAP31 S382 ochoa Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}.
Q3MIW9 MUCL3 S126 ochoa Mucin-like protein 3 (Diffuse panbronchiolitis critical region protein 1) May modulate NF-kappaB signaling and play a role in cell growth. {ECO:0000269|PubMed:29242154}.
Q5BKX6 SLC45A4 S411 ochoa Solute carrier family 45 member 4 Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}.
Q5JSH3 WDR44 S197 ochoa WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
Q5T8D3 ACBD5 S257 ochoa Acyl-CoA-binding domain-containing protein 5 Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}.
Q5TGY3 AHDC1 S1191 ochoa Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}.
Q5TH69 ARFGEF3 S1651 ochoa Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}.
Q5UIP0 RIF1 S1526 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VWN6 TASOR2 S1722 ochoa Protein TASOR 2 None
Q5XKK7 FAM219B S140 ochoa Protein FAM219B None
Q641Q2 WASHC2A S1144 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q69YN4 VIRMA S1603 ochoa Protein virilizer homolog Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}.
Q6DN90 IQSEC1 S925 ochoa IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}.
Q6VUC0 TFAP2E T231 ochoa Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}.
Q6ZU80 CEP128 S1043 ochoa Centrosomal protein of 128 kDa (Cep128) None
Q7Z417 NUFIP2 S113 ochoa FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) Binds RNA. {ECO:0000269|PubMed:12837692}.
Q7Z5H3 ARHGAP22 S395 ochoa|psp Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}.
Q8IWE2 FAM114A1 S140 ochoa Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) May play a role in neuronal cell development. {ECO:0000250}.
Q8IY63 AMOTL1 S787 ochoa Angiomotin-like protein 1 Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}.
Q8N0X7 SPART S394 ochoa Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). {ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:37443287, ECO:0000269|PubMed:38190532}.
Q8N1W1 ARHGEF28 S736 ochoa Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.
Q8N697 SLC15A4 S291 ochoa Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612}.
Q8NE79 POPDC1 S318 ochoa Popeye domain-containing protein 1 (Popeye protein 1) Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. {ECO:0000250|UniProtKB:Q5PQZ7, ECO:0000250|UniProtKB:Q9ES83, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:26642364}.
Q8NFC6 BOD1L1 S2909 ochoa Biorientation of chromosomes in cell division protein 1-like 1 Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}.
Q8NHZ8 CDC26 S52 ochoa Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). May recruit the E2 ubiquitin-conjugating enzymes to the complex (PubMed:18485873). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q8TEW8 PARD3B S746 ochoa|psp Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8TF72 SHROOM3 S664 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8WXI7 MUC16 S9580 ochoa Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
Q92481 TFAP2B T243 ochoa Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}.
Q92574 TSC1 S539 ochoa Hamartin (Tuberous sclerosis 1 protein) Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}.
Q92754 TFAP2C T237 ochoa Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}.
Q96B97 SH3KBP1 S445 ochoa SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}.
Q96DY7 MTBP S547 ochoa Mdm2-binding protein (hMTBP) Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}.
Q9BST9 RTKN S220 ochoa Rhotekin Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}.
Q9BT25 HAUS8 S21 ochoa|psp HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.
Q9BUF5 TUBB6 Y340 ochoa Tubulin beta-6 chain (Tubulin beta class V) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}.
Q9BV23 ABHD6 S115 ochoa Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6) Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:26491015}.
Q9BVA1 TUBB2B Y340 ochoa Tubulin beta-2B chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.
Q9GZV4 EIF5A2 S46 ochoa Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}.
Q9GZZ9 UBA5 S45 ochoa Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}.
Q9H1B7 IRF2BPL S337 ochoa Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}.
Q9H4L5 OSBPL3 S173 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9H582 ZNF644 S124 ochoa Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) May be involved in transcriptional regulation.
Q9H7N4 SCAF1 S941 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9NRR3 CDC42SE2 S55 ochoa CDC42 small effector protein 2 (Small effector of CDC42 protein 2) Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583}.
Q9NRY4 ARHGAP35 S1142 ochoa Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.
Q9NV70 EXOC1 S473 ochoa Exocyst complex component 1 (Exocyst complex component Sec3) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}.
Q9P0U3 SENP1 S108 ochoa Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}.
Q9P107 GMIP S886 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9UGP4 LIMD1 S256 ochoa LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UHB7 AFF4 S526 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UHL9 GTF2IRD1 S118 ochoa General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}.
Q9UJY4 GGA2 S327 ochoa ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}.
Q9UK96 FBXO10 S326 ochoa F-box only protein 10 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation (PubMed:28515150). Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling (PubMed:31570756). {ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:28515150, ECO:0000269|PubMed:31570756}.
Q9UKX2 MYH2 S649 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UPY3 DICER1 S1142 ochoa Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}.
Q9Y2W1 THRAP3 S560 ochoa Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.
Q9Y3B9 RRP15 S227 ochoa RRP15-like protein (Ribosomal RNA-processing protein 15) None
Q9Y3Z3 SAMHD1 S519 ochoa Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}.
Q9Y5P4 CERT1 S150 ochoa Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}.
Q9Y5X1 SNX9 S198 ochoa Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.
Q9Y623 MYH4 S647 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q9Y6A5 TACC3 S583 ochoa Transforming acidic coiled-coil-containing protein 3 (ERIC-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
R4GMW8 BIVM-ERCC5 S1523 ochoa DNA excision repair protein ERCC-5 None
P12277 CKB S129 Sugiyama Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}.
P68431 H3C1 Y42 EPSD Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q08881 ITK Y225 Sugiyama Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}.
Q16531 DDB1 S379 Sugiyama DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMed:16482215, PubMed:16940174, PubMed:17079684). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355, PubMed:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:38316879}.
Q01844 EWSR1 S443 Sugiyama RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Might normally function as a transcriptional repressor (PubMed:10767297). EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. {ECO:0000269|PubMed:10767297, ECO:0000269|PubMed:21256132}.
P84243 H3-3A Y42 Sugiyama Histone H3.3 Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}.
Q16695 H3-4 Y42 Sugiyama Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q71DI3 H3C15 Y42 Sugiyama Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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reactome_id name p -log10_p
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.001916e-09 8.999
R-HSA-190872 Transport of connexons to the plasma membrane 1.358232e-09 8.867
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 4.034668e-09 8.394
R-HSA-9646399 Aggrephagy 7.915844e-09 8.102
R-HSA-68886 M Phase 8.513030e-09 8.070
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.163231e-08 7.934
R-HSA-9619483 Activation of AMPK downstream of NMDARs 1.942306e-08 7.712
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.993744e-08 7.700
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 4.614512e-08 7.336
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 4.903021e-08 7.310
R-HSA-190861 Gap junction assembly 6.863067e-08 7.163
R-HSA-389977 Post-chaperonin tubulin folding pathway 8.478322e-08 7.072
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 2.010254e-07 6.697
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 2.261987e-07 6.646
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 2.447031e-07 6.611
R-HSA-68877 Mitotic Prometaphase 2.588244e-07 6.587
R-HSA-6807878 COPI-mediated anterograde transport 3.490618e-07 6.457
R-HSA-190828 Gap junction trafficking 3.358741e-07 6.474
R-HSA-5620920 Cargo trafficking to the periciliary membrane 4.039095e-07 6.394
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 4.872244e-07 6.312
R-HSA-437239 Recycling pathway of L1 4.872244e-07 6.312
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 4.865457e-07 6.313
R-HSA-157858 Gap junction trafficking and regulation 6.170778e-07 6.210
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 8.212450e-07 6.086
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 9.574883e-07 6.019
R-HSA-5617833 Cilium Assembly 1.673810e-06 5.776
R-HSA-9663891 Selective autophagy 1.841808e-06 5.735
R-HSA-983189 Kinesins 1.967585e-06 5.706
R-HSA-9609690 HCMV Early Events 2.191125e-06 5.659
R-HSA-69278 Cell Cycle, Mitotic 2.064979e-06 5.685
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 2.326491e-06 5.633
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 2.377323e-06 5.624
R-HSA-2132295 MHC class II antigen presentation 2.618975e-06 5.582
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 3.665002e-06 5.436
R-HSA-2467813 Separation of Sister Chromatids 3.471244e-06 5.460
R-HSA-8856688 Golgi-to-ER retrograde transport 4.861004e-06 5.313
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 6.044552e-06 5.219
R-HSA-1632852 Macroautophagy 8.166630e-06 5.088
R-HSA-5620924 Intraflagellar transport 8.677861e-06 5.062
R-HSA-69275 G2/M Transition 9.716342e-06 5.012
R-HSA-1640170 Cell Cycle 1.071978e-05 4.970
R-HSA-453274 Mitotic G2-G2/M phases 1.055842e-05 4.976
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 1.042541e-05 4.982
R-HSA-9833482 PKR-mediated signaling 1.042541e-05 4.982
R-HSA-199977 ER to Golgi Anterograde Transport 1.149002e-05 4.940
R-HSA-9609646 HCMV Infection 1.826249e-05 4.738
R-HSA-9612973 Autophagy 1.740624e-05 4.759
R-HSA-438064 Post NMDA receptor activation events 1.814569e-05 4.741
R-HSA-68882 Mitotic Anaphase 3.199207e-05 4.495
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.314158e-05 4.480
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 3.595870e-05 4.444
R-HSA-9834899 Specification of the neural plate border 5.428378e-05 4.265
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 5.056034e-05 4.296
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 8.295553e-05 4.081
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 9.801733e-05 4.009
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 1.008934e-04 3.996
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.071424e-04 3.970
R-HSA-948021 Transport to the Golgi and subsequent modification 1.079845e-04 3.967
R-HSA-373760 L1CAM interactions 1.200367e-04 3.921
R-HSA-1852241 Organelle biogenesis and maintenance 1.412697e-04 3.850
R-HSA-199991 Membrane Trafficking 1.516506e-04 3.819
R-HSA-390466 Chaperonin-mediated protein folding 1.680425e-04 3.775
R-HSA-391251 Protein folding 2.321734e-04 3.634
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 3.471627e-04 3.459
R-HSA-380259 Loss of Nlp from mitotic centrosomes 3.471627e-04 3.459
R-HSA-5610787 Hedgehog 'off' state 3.629119e-04 3.440
R-HSA-390522 Striated Muscle Contraction 3.780157e-04 3.422
R-HSA-8854518 AURKA Activation by TPX2 4.185969e-04 3.378
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 6.280629e-04 3.202
R-HSA-380287 Centrosome maturation 7.002313e-04 3.155
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 7.653895e-04 3.116
R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors 8.359977e-04 3.078
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.104186e-03 2.957
R-HSA-2299718 Condensation of Prophase Chromosomes 1.148147e-03 2.940
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 1.197299e-03 2.922
R-HSA-1474165 Reproduction 1.485180e-03 2.828
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.521529e-03 2.818
R-HSA-5653656 Vesicle-mediated transport 1.523105e-03 2.817
R-HSA-912446 Meiotic recombination 1.584851e-03 2.800
R-HSA-5358351 Signaling by Hedgehog 2.001899e-03 2.699
R-HSA-427975 Proton/oligopeptide cotransporters 2.105497e-03 2.677
R-HSA-913531 Interferon Signaling 2.144804e-03 2.669
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.373593e-03 2.625
R-HSA-2262752 Cellular responses to stress 2.531860e-03 2.597
R-HSA-73728 RNA Polymerase I Promoter Opening 2.762379e-03 2.559
R-HSA-422475 Axon guidance 2.841333e-03 2.546
R-HSA-597592 Post-translational protein modification 2.949587e-03 2.530
R-HSA-9959399 SLC-mediated transport of oligopeptides 3.254283e-03 2.488
R-HSA-5334118 DNA methylation 3.256210e-03 2.487
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 3.335778e-03 2.477
R-HSA-211000 Gene Silencing by RNA 3.348365e-03 2.475
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 3.454001e-03 2.462
R-HSA-204626 Hypusine synthesis from eIF5A-lysine 4.635586e-03 2.334
R-HSA-5578749 Transcriptional regulation by small RNAs 4.688055e-03 2.329
R-HSA-68616 Assembly of the ORC complex at the origin of replication 4.397924e-03 2.357
R-HSA-9924644 Developmental Lineages of the Mammary Gland 4.688055e-03 2.329
R-HSA-9764560 Regulation of CDH1 Gene Transcription 4.290587e-03 2.367
R-HSA-9675108 Nervous system development 4.690380e-03 2.329
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 5.048755e-03 2.297
R-HSA-68875 Mitotic Prophase 5.495424e-03 2.260
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 5.647135e-03 2.248
R-HSA-9764265 Regulation of CDH1 Expression and Function 5.647135e-03 2.248
R-HSA-212300 PRC2 methylates histones and DNA 5.754679e-03 2.240
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.019634e-03 2.220
R-HSA-427359 SIRT1 negatively regulates rRNA expression 6.128677e-03 2.213
R-HSA-977225 Amyloid fiber formation 6.783495e-03 2.169
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 7.048851e-03 2.152
R-HSA-5696395 Formation of Incision Complex in GG-NER 7.336476e-03 2.135
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 7.336476e-03 2.135
R-HSA-1280218 Adaptive Immune System 7.595992e-03 2.119
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 7.599961e-03 2.119
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 7.768098e-03 2.110
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 7.768098e-03 2.110
R-HSA-1500620 Meiosis 7.885856e-03 2.103
R-HSA-8953897 Cellular responses to stimuli 8.254887e-03 2.083
R-HSA-9710421 Defective pyroptosis 9.151643e-03 2.039
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 9.553069e-03 2.020
R-HSA-73772 RNA Polymerase I Promoter Escape 1.412183e-02 1.850
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 1.175897e-02 1.930
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 1.118927e-02 1.951
R-HSA-68867 Assembly of the pre-replicative complex 1.113977e-02 1.953
R-HSA-69306 DNA Replication 1.461642e-02 1.835
R-HSA-446203 Asparagine N-linked glycosylation 1.216640e-02 1.915
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 1.475154e-02 1.831
R-HSA-9827857 Specification of primordial germ cells 1.476094e-02 1.831
R-HSA-9824446 Viral Infection Pathways 1.490080e-02 1.827
R-HSA-418990 Adherens junctions interactions 1.508992e-02 1.821
R-HSA-162582 Signal Transduction 1.547494e-02 1.810
R-HSA-392499 Metabolism of proteins 1.588046e-02 1.799
R-HSA-5696398 Nucleotide Excision Repair 1.698439e-02 1.770
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 1.844423e-02 1.734
R-HSA-6807004 Negative regulation of MET activity 1.875586e-02 1.727
R-HSA-69002 DNA Replication Pre-Initiation 1.894764e-02 1.722
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 1.960101e-02 1.708
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 1.960101e-02 1.708
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 2.017760e-02 1.695
R-HSA-1266738 Developmental Biology 2.034706e-02 1.691
R-HSA-9616222 Transcriptional regulation of granulopoiesis 2.112930e-02 1.675
R-HSA-8876384 Listeria monocytogenes entry into host cells 2.164301e-02 1.665
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 2.437684e-02 1.613
R-HSA-112315 Transmission across Chemical Synapses 2.523609e-02 1.598
R-HSA-2559583 Cellular Senescence 2.602970e-02 1.585
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 2.609607e-02 1.583
R-HSA-421270 Cell-cell junction organization 2.644486e-02 1.578
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 2.787883e-02 1.555
R-HSA-3214842 HDMs demethylate histones 2.792537e-02 1.554
R-HSA-1266695 Interleukin-7 signaling 2.792537e-02 1.554
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 2.879399e-02 1.541
R-HSA-427413 NoRC negatively regulates rRNA expression 2.879399e-02 1.541
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 3.015461e-02 1.521
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 3.015461e-02 1.521
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 3.015461e-02 1.521
R-HSA-5696394 DNA Damage Recognition in GG-NER 4.431289e-02 1.353
R-HSA-5696400 Dual Incision in GG-NER 4.630920e-02 1.334
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 3.261257e-02 1.487
R-HSA-8856828 Clathrin-mediated endocytosis 4.628907e-02 1.335
R-HSA-9708296 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 3.274185e-02 1.485
R-HSA-165181 Inhibition of TSC complex formation by PKB 4.871149e-02 1.312
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 3.773863e-02 1.423
R-HSA-182971 EGFR downregulation 3.852604e-02 1.414
R-HSA-73894 DNA Repair 4.037383e-02 1.394
R-HSA-73854 RNA Polymerase I Promoter Clearance 3.360655e-02 1.474
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 4.211833e-02 1.376
R-HSA-73864 RNA Polymerase I Transcription 3.564144e-02 1.448
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 4.833807e-02 1.316
R-HSA-446728 Cell junction organization 3.914887e-02 1.407
R-HSA-9645723 Diseases of programmed cell death 4.793578e-02 1.319
R-HSA-1912408 Pre-NOTCH Transcription and Translation 5.160598e-02 1.287
R-HSA-9758941 Gastrulation 5.163172e-02 1.287
R-HSA-180910 Vpr-mediated nuclear import of PICs 5.249080e-02 1.280
R-HSA-112316 Neuronal System 5.253998e-02 1.280
R-HSA-5693532 DNA Double-Strand Break Repair 5.537353e-02 1.257
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 5.659790e-02 1.247
R-HSA-8866376 Reelin signalling pathway 5.659790e-02 1.247
R-HSA-9670095 Inhibition of DNA recombination at telomere 5.894760e-02 1.230
R-HSA-176033 Interactions of Vpr with host cellular proteins 5.894760e-02 1.230
R-HSA-3214841 PKMTs methylate histone lysines 6.115806e-02 1.214
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 6.115806e-02 1.214
R-HSA-1500931 Cell-Cell communication 6.274132e-02 1.202
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 6.441941e-02 1.191
R-HSA-3214847 HATs acetylate histones 6.478426e-02 1.189
R-HSA-69618 Mitotic Spindle Checkpoint 6.617985e-02 1.179
R-HSA-157118 Signaling by NOTCH 6.704482e-02 1.174
R-HSA-212165 Epigenetic regulation of gene expression 6.784025e-02 1.169
R-HSA-8854214 TBC/RABGAPs 6.795532e-02 1.168
R-HSA-9842860 Regulation of endogenous retroelements 6.901227e-02 1.161
R-HSA-2559580 Oxidative Stress Induced Senescence 6.901227e-02 1.161
R-HSA-3214858 RMTs methylate histone arginines 7.027437e-02 1.153
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 7.217655e-02 1.142
R-HSA-177539 Autointegration results in viral DNA circles 7.217655e-02 1.142
R-HSA-426486 Small interfering RNA (siRNA) biogenesis 7.217655e-02 1.142
R-HSA-175567 Integration of viral DNA into host genomic DNA 7.217655e-02 1.142
R-HSA-109582 Hemostasis 7.330358e-02 1.135
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 7.336261e-02 1.135
R-HSA-5619507 Activation of HOX genes during differentiation 7.336261e-02 1.135
R-HSA-139915 Activation of PUMA and translocation to mitochondria 7.986985e-02 1.098
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 7.986985e-02 1.098
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 7.986985e-02 1.098
R-HSA-9766229 Degradation of CDH1 8.224325e-02 1.085
R-HSA-69620 Cell Cycle Checkpoints 8.358102e-02 1.078
R-HSA-1912422 Pre-NOTCH Expression and Processing 8.712091e-02 1.060
R-HSA-201681 TCF dependent signaling in response to WNT 8.912603e-02 1.050
R-HSA-112382 Formation of RNA Pol II elongation complex 8.970336e-02 1.047
R-HSA-176412 Phosphorylation of the APC/C 1.534043e-01 0.814
R-HSA-5083625 Defective GALNT3 causes HFTC 1.534043e-01 0.814
R-HSA-5083636 Defective GALNT12 causes CRCS1 1.534043e-01 0.814
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 1.534043e-01 0.814
R-HSA-5083632 Defective C1GALT1C1 causes TNPS 1.673956e-01 0.776
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 1.811573e-01 0.742
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 9.994549e-02 1.000
R-HSA-6782135 Dual incision in TC-NER 1.051840e-01 0.978
R-HSA-3214815 HDACs deacetylate histones 9.735486e-02 1.012
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 1.078308e-01 0.967
R-HSA-162592 Integration of provirus 1.173969e-01 0.930
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 1.673956e-01 0.776
R-HSA-75955 RNA Polymerase II Transcription Elongation 9.223329e-02 1.035
R-HSA-5693606 DNA Double Strand Break Response 1.296069e-01 0.887
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 9.506702e-02 1.022
R-HSA-8951664 Neddylation 1.424987e-01 0.846
R-HSA-9603798 Class I peroxisomal membrane protein import 1.534043e-01 0.814
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.604289e-01 0.795
R-HSA-674695 RNA Polymerase II Pre-transcription Events 1.494149e-01 0.826
R-HSA-426048 Arachidonate production from DAG 1.025719e-01 0.989
R-HSA-164843 2-LTR circle formation 1.025719e-01 0.989
R-HSA-71032 Propionyl-CoA catabolism 1.100150e-01 0.959
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration 1.173969e-01 0.930
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 1.173969e-01 0.930
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.604289e-01 0.795
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1.391797e-01 0.856
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 1.319787e-01 0.879
R-HSA-196780 Biotin transport and metabolism 1.463214e-01 0.835
R-HSA-162587 HIV Life Cycle 1.795144e-01 0.746
R-HSA-9018519 Estrogen-dependent gene expression 1.359648e-01 0.867
R-HSA-177929 Signaling by EGFR 9.994549e-02 1.000
R-HSA-3323169 Defects in biotin (Btn) metabolism 9.506702e-02 1.022
R-HSA-69473 G2/M DNA damage checkpoint 1.494149e-01 0.826
R-HSA-9610379 HCMV Late Events 1.795144e-01 0.746
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 1.025719e-01 0.989
R-HSA-2028269 Signaling by Hippo 1.673956e-01 0.776
R-HSA-9764561 Regulation of CDH1 Function 1.025554e-01 0.989
R-HSA-5693607 Processing of DNA double-strand break ends 1.697808e-01 0.770
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1.319787e-01 0.879
R-HSA-9679191 Potential therapeutics for SARS 1.652521e-01 0.782
R-HSA-9012852 Signaling by NOTCH3 9.735486e-02 1.012
R-HSA-397014 Muscle contraction 1.292133e-01 0.889
R-HSA-5693538 Homology Directed Repair 9.851836e-02 1.006
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 1.811573e-01 0.742
R-HSA-5663205 Infectious disease 1.188789e-01 0.925
R-HSA-6806834 Signaling by MET 1.668421e-01 0.778
R-HSA-9856651 MITF-M-dependent gene expression 1.652521e-01 0.782
R-HSA-141424 Amplification of signal from the kinetochores 1.845996e-01 0.734
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.845996e-01 0.734
R-HSA-5633007 Regulation of TP53 Activity 1.857282e-01 0.731
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 1.875861e-01 0.727
R-HSA-5620916 VxPx cargo-targeting to cilium 1.879533e-01 0.726
R-HSA-71288 Creatine metabolism 1.879533e-01 0.726
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.946933e-01 0.711
R-HSA-162594 Early Phase of HIV Life Cycle 1.946933e-01 0.711
R-HSA-73884 Base Excision Repair 1.995971e-01 0.700
R-HSA-1280215 Cytokine Signaling in Immune system 2.012531e-01 0.696
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 2.013777e-01 0.696
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 2.080071e-01 0.682
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 2.080071e-01 0.682
R-HSA-9734767 Developmental Cell Lineages 2.107256e-01 0.676
R-HSA-9909648 Regulation of PD-L1(CD274) expression 2.132670e-01 0.671
R-HSA-977068 Termination of O-glycan biosynthesis 2.145819e-01 0.668
R-HSA-74160 Gene expression (Transcription) 2.160764e-01 0.665
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 2.211024e-01 0.655
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 2.211024e-01 0.655
R-HSA-168256 Immune System 2.252540e-01 0.647
R-HSA-157579 Telomere Maintenance 2.269209e-01 0.644
R-HSA-203927 MicroRNA (miRNA) biogenesis 2.275693e-01 0.643
R-HSA-400685 Sema4D in semaphorin signaling 2.275693e-01 0.643
R-HSA-8957275 Post-translational protein phosphorylation 2.299758e-01 0.638
R-HSA-3295583 TRP channels 2.339828e-01 0.631
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.403435e-01 0.619
R-HSA-171306 Packaging Of Telomere Ends 2.403435e-01 0.619
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.403435e-01 0.619
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.403435e-01 0.619
R-HSA-264876 Insulin processing 2.403435e-01 0.619
R-HSA-167287 HIV elongation arrest and recovery 2.466518e-01 0.608
R-HSA-167290 Pausing and recovery of HIV elongation 2.466518e-01 0.608
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 2.483558e-01 0.605
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.591128e-01 0.587
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 2.591128e-01 0.587
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 2.591128e-01 0.587
R-HSA-114452 Activation of BH3-only proteins 2.591128e-01 0.587
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 2.591128e-01 0.587
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.652663e-01 0.576
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.652663e-01 0.576
R-HSA-2129379 Molecules associated with elastic fibres 2.652663e-01 0.576
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 2.652663e-01 0.576
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 2.713692e-01 0.566
R-HSA-9675126 Diseases of mitotic cell cycle 2.713692e-01 0.566
R-HSA-195721 Signaling by WNT 2.733028e-01 0.563
R-HSA-389948 Co-inhibition by PD-1 2.750505e-01 0.561
R-HSA-1855170 IPs transport between nucleus and cytosol 2.774217e-01 0.557
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.774217e-01 0.557
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.774217e-01 0.557
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 2.821449e-01 0.550
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.834243e-01 0.548
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.834243e-01 0.548
R-HSA-114508 Effects of PIP2 hydrolysis 2.834243e-01 0.548
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 2.852147e-01 0.545
R-HSA-5628897 TP53 Regulates Metabolic Genes 2.882833e-01 0.540
R-HSA-180746 Nuclear import of Rev protein 2.893774e-01 0.539
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 2.893774e-01 0.539
R-HSA-909733 Interferon alpha/beta signaling 2.913506e-01 0.536
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 2.952814e-01 0.530
R-HSA-3296482 Defects in vitamin and cofactor metabolism 2.952814e-01 0.530
R-HSA-9007101 Rab regulation of trafficking 2.974802e-01 0.527
R-HSA-9730414 MITF-M-regulated melanocyte development 3.066632e-01 0.513
R-HSA-110331 Cleavage of the damaged purine 3.069437e-01 0.513
R-HSA-73886 Chromosome Maintenance 3.097148e-01 0.509
R-HSA-73927 Depurination 3.127029e-01 0.505
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 3.127029e-01 0.505
R-HSA-1566948 Elastic fibre formation 3.127029e-01 0.505
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 3.184145e-01 0.497
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 3.184145e-01 0.497
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.184145e-01 0.497
R-HSA-162909 Host Interactions of HIV factors 3.188638e-01 0.496
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 3.240790e-01 0.489
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 3.240790e-01 0.489
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 3.240790e-01 0.489
R-HSA-167169 HIV Transcription Elongation 3.240790e-01 0.489
R-HSA-177243 Interactions of Rev with host cellular proteins 3.240790e-01 0.489
R-HSA-9604323 Negative regulation of NOTCH4 signaling 3.240790e-01 0.489
R-HSA-202433 Generation of second messenger molecules 3.240790e-01 0.489
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 3.296968e-01 0.482
R-HSA-73933 Resolution of Abasic Sites (AP sites) 3.296968e-01 0.482
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 3.296968e-01 0.482
R-HSA-8853884 Transcriptional Regulation by VENTX 3.296968e-01 0.482
R-HSA-69481 G2/M Checkpoints 3.310183e-01 0.480
R-HSA-8878171 Transcriptional regulation by RUNX1 3.361554e-01 0.473
R-HSA-162906 HIV Infection 3.384242e-01 0.471
R-HSA-165159 MTOR signalling 3.407938e-01 0.468
R-HSA-110329 Cleavage of the damaged pyrimidine 3.407938e-01 0.468
R-HSA-73928 Depyrimidination 3.407938e-01 0.468
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 3.462737e-01 0.461
R-HSA-3928662 EPHB-mediated forward signaling 3.517083e-01 0.454
R-HSA-3247509 Chromatin modifying enzymes 3.542907e-01 0.451
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 3.570982e-01 0.447
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 3.570982e-01 0.447
R-HSA-8939211 ESR-mediated signaling 3.610788e-01 0.442
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 3.624435e-01 0.441
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 3.624435e-01 0.441
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 3.624435e-01 0.441
R-HSA-6798695 Neutrophil degranulation 3.667144e-01 0.436
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 3.677447e-01 0.434
R-HSA-73893 DNA Damage Bypass 3.782163e-01 0.422
R-HSA-3700989 Transcriptional Regulation by TP53 3.799188e-01 0.420
R-HSA-5658442 Regulation of RAS by GAPs 3.833874e-01 0.416
R-HSA-9748787 Azathioprine ADME 3.833874e-01 0.416
R-HSA-162599 Late Phase of HIV Life Cycle 3.848514e-01 0.415
R-HSA-4839726 Chromatin organization 3.881144e-01 0.411
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 3.885157e-01 0.411
R-HSA-9864848 Complex IV assembly 3.885157e-01 0.411
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.936018e-01 0.405
R-HSA-6794361 Neurexins and neuroligins 3.936018e-01 0.405
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 3.936018e-01 0.405
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 3.986458e-01 0.399
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 3.986458e-01 0.399
R-HSA-1221632 Meiotic synapsis 3.986458e-01 0.399
R-HSA-432722 Golgi Associated Vesicle Biogenesis 3.986458e-01 0.399
R-HSA-8956320 Nucleotide biosynthesis 3.986458e-01 0.399
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 4.036482e-01 0.394
R-HSA-73929 Base-Excision Repair, AP Site Formation 4.036482e-01 0.394
R-HSA-388841 Regulation of T cell activation by CD28 family 4.037672e-01 0.394
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 4.086093e-01 0.389
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 4.135294e-01 0.383
R-HSA-193648 NRAGE signals death through JNK 4.135294e-01 0.383
R-HSA-109606 Intrinsic Pathway for Apoptosis 4.135294e-01 0.383
R-HSA-2980766 Nuclear Envelope Breakdown 4.184089e-01 0.378
R-HSA-5621480 Dectin-2 family 4.184089e-01 0.378
R-HSA-191859 snRNP Assembly 4.280473e-01 0.369
R-HSA-194441 Metabolism of non-coding RNA 4.280473e-01 0.369
R-HSA-1660661 Sphingolipid de novo biosynthesis 4.328069e-01 0.364
R-HSA-8943724 Regulation of PTEN gene transcription 4.328069e-01 0.364
R-HSA-212436 Generic Transcription Pathway 4.372295e-01 0.359
R-HSA-168325 Viral Messenger RNA Synthesis 4.375271e-01 0.359
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 4.422084e-01 0.354
R-HSA-6784531 tRNA processing in the nucleus 4.422084e-01 0.354
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.422084e-01 0.354
R-HSA-8848021 Signaling by PTK6 4.468510e-01 0.350
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 4.468510e-01 0.350
R-HSA-373755 Semaphorin interactions 4.468510e-01 0.350
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 4.543075e-01 0.343
R-HSA-1234174 Cellular response to hypoxia 4.560215e-01 0.341
R-HSA-73857 RNA Polymerase II Transcription 4.598392e-01 0.337
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 4.607770e-01 0.337
R-HSA-913709 O-linked glycosylation of mucins 4.694950e-01 0.328
R-HSA-167172 Transcription of the HIV genome 4.694950e-01 0.328
R-HSA-453276 Regulation of mitotic cell cycle 4.826372e-01 0.316
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 4.826372e-01 0.316
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 4.826372e-01 0.316
R-HSA-199992 trans-Golgi Network Vesicle Budding 4.869457e-01 0.313
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 4.912186e-01 0.309
R-HSA-69052 Switching of origins to a post-replicative state 4.912186e-01 0.309
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 4.912186e-01 0.309
R-HSA-9013694 Signaling by NOTCH4 4.954562e-01 0.305
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 4.996587e-01 0.301
R-HSA-1169408 ISG15 antiviral mechanism 4.996587e-01 0.301
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 5.120590e-01 0.291
R-HSA-416482 G alpha (12/13) signalling events 5.120590e-01 0.291
R-HSA-9679506 SARS-CoV Infections 5.251278e-01 0.280
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 5.281195e-01 0.277
R-HSA-72163 mRNA Splicing - Major Pathway 5.304694e-01 0.275
R-HSA-9707564 Cytoprotection by HMOX1 5.320519e-01 0.274
R-HSA-390918 Peroxisomal lipid metabolism 5.359518e-01 0.271
R-HSA-6794362 Protein-protein interactions at synapses 5.398195e-01 0.268
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 5.474591e-01 0.262
R-HSA-376176 Signaling by ROBO receptors 5.528181e-01 0.257
R-HSA-72172 mRNA Splicing 5.576827e-01 0.254
R-HSA-2682334 EPH-Ephrin signaling 5.732195e-01 0.242
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 5.767788e-01 0.239
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 5.838091e-01 0.234
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 5.838091e-01 0.234
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 5.907236e-01 0.229
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.941379e-01 0.226
R-HSA-193704 p75 NTR receptor-mediated signalling 6.008820e-01 0.221
R-HSA-192105 Synthesis of bile acids and bile salts 6.008820e-01 0.221
R-HSA-1643685 Disease 6.024850e-01 0.220
R-HSA-70171 Glycolysis 6.042122e-01 0.219
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 6.107901e-01 0.214
R-HSA-9006931 Signaling by Nuclear Receptors 6.203970e-01 0.207
R-HSA-9692914 SARS-CoV-1-host interactions 6.267639e-01 0.203
R-HSA-69239 Synthesis of DNA 6.298798e-01 0.201
R-HSA-15869 Metabolism of nucleotides 6.304033e-01 0.200
R-HSA-2672351 Stimuli-sensing channels 6.329697e-01 0.199
R-HSA-202403 TCR signaling 6.390731e-01 0.194
R-HSA-194068 Bile acid and bile salt metabolism 6.390731e-01 0.194
R-HSA-1483249 Inositol phosphate metabolism 6.450757e-01 0.190
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 6.480398e-01 0.188
R-HSA-983169 Class I MHC mediated antigen processing & presentation 6.562351e-01 0.183
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 6.567853e-01 0.183
R-HSA-2871809 FCERI mediated Ca+2 mobilization 6.596523e-01 0.181
R-HSA-70326 Glucose metabolism 6.653151e-01 0.177
R-HSA-2980736 Peptide hormone metabolism 6.653151e-01 0.177
R-HSA-3371556 Cellular response to heat stress 6.763617e-01 0.170
R-HSA-9711123 Cellular response to chemical stress 6.935585e-01 0.159
R-HSA-8956319 Nucleotide catabolism 6.999109e-01 0.155
R-HSA-9843745 Adipogenesis 7.073763e-01 0.150
R-HSA-5173105 O-linked glycosylation 7.240864e-01 0.140
R-HSA-6807070 PTEN Regulation 7.286843e-01 0.137
R-HSA-9664422 FCGR3A-mediated phagocytosis 7.309546e-01 0.136
R-HSA-9664407 Parasite infection 7.309546e-01 0.136
R-HSA-9664417 Leishmania phagocytosis 7.309546e-01 0.136
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 7.332061e-01 0.135
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 7.376531e-01 0.132
R-HSA-69242 S Phase 7.505575e-01 0.125
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.567714e-01 0.121
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 7.588083e-01 0.120
R-HSA-9609507 Protein localization 7.608284e-01 0.119
R-HSA-73887 Death Receptor Signaling 7.628316e-01 0.118
R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.648182e-01 0.116
R-HSA-1989781 PPARA activates gene expression 7.648182e-01 0.116
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7.687420e-01 0.114
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 7.706794e-01 0.113
R-HSA-9006936 Signaling by TGFB family members 7.745061e-01 0.111
R-HSA-109581 Apoptosis 7.782694e-01 0.109
R-HSA-5619102 SLC transporter disorders 7.874071e-01 0.104
R-HSA-72306 tRNA processing 7.944473e-01 0.100
R-HSA-5621481 C-type lectin receptors (CLRs) 7.961709e-01 0.099
R-HSA-168249 Innate Immune System 7.998497e-01 0.097
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 8.012561e-01 0.096
R-HSA-9678108 SARS-CoV-1 Infection 8.029230e-01 0.095
R-HSA-611105 Respiratory electron transport 8.078410e-01 0.093
R-HSA-168255 Influenza Infection 8.094531e-01 0.092
R-HSA-3781865 Diseases of glycosylation 8.173144e-01 0.088
R-HSA-983712 Ion channel transport 8.248537e-01 0.084
R-HSA-168898 Toll-like Receptor Cascades 8.277822e-01 0.082
R-HSA-428157 Sphingolipid metabolism 8.417114e-01 0.075
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 8.443601e-01 0.073
R-HSA-5357801 Programmed Cell Death 8.482507e-01 0.071
R-HSA-9824439 Bacterial Infection Pathways 8.588996e-01 0.066
R-HSA-9748784 Drug ADME 8.640247e-01 0.063
R-HSA-425407 SLC-mediated transmembrane transport 8.652799e-01 0.063
R-HSA-8978868 Fatty acid metabolism 8.739400e-01 0.059
R-HSA-9705683 SARS-CoV-2-host interactions 8.750412e-01 0.058
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.771358e-01 0.057
R-HSA-5668914 Diseases of metabolism 8.897523e-01 0.051
R-HSA-5619115 Disorders of transmembrane transporters 8.935892e-01 0.049
R-HSA-416476 G alpha (q) signalling events 9.078534e-01 0.042
R-HSA-76002 Platelet activation, signaling and aggregation 9.153398e-01 0.038
R-HSA-9658195 Leishmania infection 9.202179e-01 0.036
R-HSA-9824443 Parasitic Infection Pathways 9.202179e-01 0.036
R-HSA-5673001 RAF/MAP kinase cascade 9.254521e-01 0.034
R-HSA-1257604 PIP3 activates AKT signaling 9.291527e-01 0.032
R-HSA-5684996 MAPK1/MAPK3 signaling 9.297515e-01 0.032
R-HSA-8957322 Metabolism of steroids 9.446230e-01 0.025
R-HSA-1474244 Extracellular matrix organization 9.478236e-01 0.023
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.520799e-01 0.021
R-HSA-9006925 Intracellular signaling by second messengers 9.524861e-01 0.021
R-HSA-5683057 MAPK family signaling cascades 9.544664e-01 0.020
R-HSA-9694516 SARS-CoV-2 Infection 9.552353e-01 0.020
R-HSA-196854 Metabolism of vitamins and cofactors 9.606062e-01 0.017
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 9.701593e-01 0.013
R-HSA-449147 Signaling by Interleukins 9.726579e-01 0.012
R-HSA-8953854 Metabolism of RNA 9.757451e-01 0.011
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.820600e-01 0.008
R-HSA-388396 GPCR downstream signalling 9.909962e-01 0.004
R-HSA-382551 Transport of small molecules 9.910350e-01 0.004
R-HSA-372790 Signaling by GPCR 9.952350e-01 0.002
R-HSA-71291 Metabolism of amino acids and derivatives 9.955983e-01 0.002
R-HSA-556833 Metabolism of lipids 9.962214e-01 0.002
R-HSA-1430728 Metabolism 9.999997e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.768 0.181 2 0.812
MOSMOS 0.760 0.271 1 0.715
MST4MST4 0.760 0.138 2 0.819
GRK1GRK1 0.755 0.255 -2 0.771
CLK3CLK3 0.750 0.052 1 0.677
NLKNLK 0.749 0.041 1 0.717
PKN2PKN2 0.749 0.094 -3 0.778
PKN3PKN3 0.749 0.082 -3 0.775
WNK1WNK1 0.747 0.051 -2 0.759
RAF1RAF1 0.747 0.040 1 0.767
PRPKPRPK 0.747 -0.002 -1 0.308
MTORMTOR 0.747 -0.019 1 0.725
IKKBIKKB 0.746 0.024 -2 0.635
KISKIS 0.744 0.092 1 0.587
PIM3PIM3 0.744 -0.011 -3 0.800
TBK1TBK1 0.744 0.033 1 0.731
DSTYKDSTYK 0.743 0.025 2 0.839
MLK1MLK1 0.743 0.059 2 0.782
PKCDPKCD 0.743 0.043 2 0.774
RIPK3RIPK3 0.743 0.047 3 0.668
IKKEIKKE 0.743 0.047 1 0.729
CAMK2GCAMK2G 0.742 0.040 2 0.722
CDC7CDC7 0.742 -0.062 1 0.692
CAMK1BCAMK1B 0.740 -0.010 -3 0.803
GCN2GCN2 0.740 -0.053 2 0.714
CHAK2CHAK2 0.739 -0.014 -1 0.312
NIKNIK 0.739 0.003 -3 0.824
MLK3MLK3 0.738 0.062 2 0.740
ULK2ULK2 0.738 -0.078 2 0.721
SRPK1SRPK1 0.737 0.027 -3 0.697
BMPR2BMPR2 0.737 -0.084 -2 0.701
PDHK4PDHK4 0.737 -0.138 1 0.760
CDKL1CDKL1 0.737 -0.004 -3 0.741
NUAK2NUAK2 0.736 -0.022 -3 0.794
NEK6NEK6 0.736 -0.048 -2 0.674
BCKDKBCKDK 0.736 -0.036 -1 0.269
PIM1PIM1 0.736 0.001 -3 0.742
PRKD2PRKD2 0.735 -0.014 -3 0.743
ERK5ERK5 0.735 -0.047 1 0.656
PKCBPKCB 0.735 0.040 2 0.739
TGFBR2TGFBR2 0.735 -0.032 -2 0.604
NDR1NDR1 0.734 -0.021 -3 0.798
AMPKA1AMPKA1 0.734 -0.018 -3 0.810
AURCAURC 0.734 0.004 -2 0.539
PKCAPKCA 0.734 0.044 2 0.730
PKACGPKACG 0.734 -0.006 -2 0.633
NDR2NDR2 0.734 -0.047 -3 0.816
PKCGPKCG 0.734 0.048 2 0.721
PDHK1PDHK1 0.733 -0.106 1 0.758
IRE1IRE1 0.733 -0.013 1 0.667
NEK7NEK7 0.733 -0.070 -3 0.771
SKMLCKSKMLCK 0.733 -0.033 -2 0.733
MNK2MNK2 0.732 -0.012 -2 0.639
MLK2MLK2 0.732 -0.027 2 0.790
RIPK1RIPK1 0.732 -0.039 1 0.724
FAM20CFAM20C 0.732 0.088 2 0.674
GRK5GRK5 0.731 -0.089 -3 0.784
IKKAIKKA 0.731 -0.014 -2 0.617
MAPKAPK3MAPKAPK3 0.731 -0.025 -3 0.739
GRK6GRK6 0.731 -0.004 1 0.697
CDKL5CDKL5 0.731 -0.020 -3 0.737
WNK3WNK3 0.731 -0.082 1 0.720
PKRPKR 0.731 0.022 1 0.714
MST3MST3 0.731 0.132 2 0.789
CAMLCKCAMLCK 0.730 -0.037 -2 0.694
PKCHPKCH 0.730 0.033 2 0.708
ATRATR 0.730 -0.074 1 0.670
GRK7GRK7 0.730 0.080 1 0.646
ANKRD3ANKRD3 0.730 0.016 1 0.749
RSK2RSK2 0.730 -0.027 -3 0.731
HUNKHUNK 0.729 -0.061 2 0.701
PHKG1PHKG1 0.729 0.027 -3 0.781
PKCZPKCZ 0.728 -0.012 2 0.744
DLKDLK 0.728 -0.021 1 0.696
CDK1CDK1 0.728 0.034 1 0.535
CAMK2DCAMK2D 0.728 -0.051 -3 0.780
NEK9NEK9 0.727 -0.103 2 0.781
BMPR1BBMPR1B 0.727 0.037 1 0.637
P70S6KBP70S6KB 0.727 -0.022 -3 0.748
PRKD1PRKD1 0.727 -0.068 -3 0.784
YSK4YSK4 0.727 0.029 1 0.706
MNK1MNK1 0.727 -0.005 -2 0.644
AMPKA2AMPKA2 0.727 -0.031 -3 0.784
TSSK2TSSK2 0.727 -0.044 -5 0.784
MLK4MLK4 0.726 0.011 2 0.704
CDK5CDK5 0.726 0.021 1 0.575
CAMK4CAMK4 0.726 -0.030 -3 0.770
ICKICK 0.726 -0.047 -3 0.782
CAMK2BCAMK2B 0.725 0.002 2 0.718
PKG2PKG2 0.725 0.001 -2 0.563
GRK4GRK4 0.725 -0.021 -2 0.738
TTBK2TTBK2 0.725 -0.025 2 0.614
RSK3RSK3 0.725 -0.044 -3 0.720
SRPK2SRPK2 0.725 0.013 -3 0.624
DAPK2DAPK2 0.725 -0.075 -3 0.806
MARK4MARK4 0.725 -0.081 4 0.780
CHAK1CHAK1 0.725 -0.032 2 0.716
ULK1ULK1 0.725 -0.107 -3 0.761
AURBAURB 0.725 -0.008 -2 0.535
P90RSKP90RSK 0.725 -0.054 -3 0.734
CDK7CDK7 0.724 -0.026 1 0.569
MELKMELK 0.723 -0.039 -3 0.764
MAPKAPK2MAPKAPK2 0.723 -0.018 -3 0.707
PRKD3PRKD3 0.723 -0.019 -3 0.691
TGFBR1TGFBR1 0.723 0.009 -2 0.635
TSSK1TSSK1 0.722 -0.057 -3 0.835
HIPK4HIPK4 0.722 -0.059 1 0.671
TAO3TAO3 0.722 0.057 1 0.705
MEKK3MEKK3 0.722 0.083 1 0.702
PAK6PAK6 0.722 -0.012 -2 0.570
LATS1LATS1 0.722 0.001 -3 0.837
PAK1PAK1 0.721 -0.045 -2 0.650
CAMK2ACAMK2A 0.721 -0.019 2 0.714
MASTLMASTL 0.721 -0.127 -2 0.683
NEK2NEK2 0.721 -0.066 2 0.757
PLK1PLK1 0.721 -0.024 -2 0.598
SRPK3SRPK3 0.721 0.012 -3 0.659
CDK18CDK18 0.721 -0.002 1 0.512
IRE2IRE2 0.720 -0.043 2 0.711
SGK3SGK3 0.720 -0.001 -3 0.707
DNAPKDNAPK 0.720 -0.014 1 0.670
PRKXPRKX 0.720 0.018 -3 0.659
CLK4CLK4 0.720 -0.011 -3 0.719
AKT2AKT2 0.720 0.010 -3 0.640
DRAK1DRAK1 0.720 -0.010 1 0.691
PKCEPKCE 0.720 0.059 2 0.714
NIM1NIM1 0.720 -0.104 3 0.714
MYLK4MYLK4 0.720 -0.011 -2 0.657
QIKQIK 0.720 -0.069 -3 0.767
CLK1CLK1 0.719 0.000 -3 0.698
CDK2CDK2 0.719 0.012 1 0.595
ZAKZAK 0.719 0.001 1 0.672
ALK4ALK4 0.719 -0.035 -2 0.653
RSK4RSK4 0.719 -0.010 -3 0.716
CDK3CDK3 0.719 0.044 1 0.483
PKCTPKCT 0.719 0.007 2 0.722
IRAK4IRAK4 0.719 -0.036 1 0.688
ALK2ALK2 0.718 0.008 -2 0.665
PKACBPKACB 0.718 -0.008 -2 0.560
ATMATM 0.718 -0.058 1 0.626
CDK8CDK8 0.718 -0.049 1 0.549
CK1ECK1E 0.718 0.075 -3 0.475
PKCIPKCI 0.718 0.009 2 0.718
CDK10CDK10 0.718 0.038 1 0.550
LATS2LATS2 0.718 -0.080 -5 0.647
CDK13CDK13 0.717 -0.031 1 0.559
PAK3PAK3 0.717 -0.079 -2 0.649
NUAK1NUAK1 0.717 -0.064 -3 0.754
MEK1MEK1 0.717 -0.083 2 0.756
CDK16CDK16 0.717 0.031 1 0.484
HIPK1HIPK1 0.717 -0.004 1 0.613
HIPK2HIPK2 0.717 -0.001 1 0.533
PHKG2PHKG2 0.717 0.030 -3 0.748
HPK1HPK1 0.716 0.129 1 0.763
CAMK1GCAMK1G 0.716 0.003 -3 0.703
MPSK1MPSK1 0.716 0.005 1 0.642
WNK4WNK4 0.716 -0.045 -2 0.748
JNK2JNK2 0.716 -0.002 1 0.547
GCKGCK 0.715 0.119 1 0.745
ACVR2BACVR2B 0.715 0.020 -2 0.606
PIM2PIM2 0.715 -0.016 -3 0.698
AURAAURA 0.715 -0.011 -2 0.503
VRK2VRK2 0.715 -0.143 1 0.724
HRIHRI 0.714 -0.078 -2 0.648
CLK2CLK2 0.714 0.018 -3 0.716
ACVR2AACVR2A 0.714 -0.021 -2 0.579
AKT1AKT1 0.714 0.006 -3 0.663
MINKMINK 0.714 0.110 1 0.742
CDK17CDK17 0.714 -0.005 1 0.471
MEKK2MEKK2 0.714 -0.010 2 0.759
TAO2TAO2 0.714 0.038 2 0.808
KHS2KHS2 0.713 0.129 1 0.769
ERK2ERK2 0.713 -0.027 1 0.583
ERK1ERK1 0.713 -0.020 1 0.544
P38AP38A 0.713 -0.035 1 0.597
CDK19CDK19 0.713 -0.046 1 0.521
PERKPERK 0.713 -0.077 -2 0.663
MEK5MEK5 0.713 -0.051 2 0.758
NEK11NEK11 0.713 0.063 1 0.741
CDK14CDK14 0.712 0.001 1 0.561
BRAFBRAF 0.712 -0.065 -4 0.712
TNIKTNIK 0.712 0.085 3 0.826
JNK3JNK3 0.712 -0.015 1 0.570
KHS1KHS1 0.712 0.114 1 0.760
CDK12CDK12 0.712 -0.030 1 0.543
PLK3PLK3 0.712 -0.045 2 0.651
GAKGAK 0.712 0.067 1 0.683
GRK2GRK2 0.711 -0.010 -2 0.631
MSK2MSK2 0.711 -0.064 -3 0.681
PLK4PLK4 0.711 -0.035 2 0.503
PAK2PAK2 0.711 -0.079 -2 0.637
DYRK2DYRK2 0.711 -0.047 1 0.600
DCAMKL1DCAMKL1 0.711 -0.036 -3 0.756
MEKK1MEKK1 0.711 -0.069 1 0.690
P38GP38G 0.710 -0.009 1 0.467
QSKQSK 0.710 -0.083 4 0.756
BMPR1ABMPR1A 0.710 0.004 1 0.619
CDK9CDK9 0.710 -0.047 1 0.573
HASPINHASPIN 0.710 0.030 -1 0.277
SIKSIK 0.709 -0.070 -3 0.717
NEK5NEK5 0.709 -0.084 1 0.709
CK1DCK1D 0.709 0.065 -3 0.422
TAK1TAK1 0.709 0.103 1 0.731
SSTKSSTK 0.709 -0.022 4 0.750
HGKHGK 0.708 0.037 3 0.818
P38BP38B 0.708 -0.029 1 0.537
CHK1CHK1 0.708 -0.096 -3 0.816
MSK1MSK1 0.708 -0.045 -3 0.694
TLK2TLK2 0.708 -0.114 1 0.662
SMG1SMG1 0.708 -0.117 1 0.630
PDK1PDK1 0.708 0.011 1 0.783
PKN1PKN1 0.707 0.017 -3 0.664
MARK3MARK3 0.707 -0.065 4 0.727
SNRKSNRK 0.707 -0.081 2 0.568
PASKPASK 0.706 -0.007 -3 0.802
IRAK1IRAK1 0.706 -0.103 -1 0.279
MST2MST2 0.706 0.053 1 0.723
HIPK3HIPK3 0.706 -0.037 1 0.632
NEK8NEK8 0.706 -0.043 2 0.758
PKACAPKACA 0.706 -0.017 -2 0.511
BRSK1BRSK1 0.706 -0.066 -3 0.745
BRSK2BRSK2 0.706 -0.077 -3 0.763
CK2A2CK2A2 0.705 0.059 1 0.557
DCAMKL2DCAMKL2 0.705 -0.026 -3 0.775
MAPKAPK5MAPKAPK5 0.705 -0.091 -3 0.647
LOKLOK 0.705 -0.001 -2 0.622
PRP4PRP4 0.705 -0.024 -3 0.708
EEF2KEEF2K 0.704 0.022 3 0.822
GSK3AGSK3A 0.703 0.012 4 0.475
NEK4NEK4 0.703 -0.038 1 0.722
ERK7ERK7 0.703 -0.014 2 0.526
SMMLCKSMMLCK 0.703 -0.046 -3 0.750
CK1A2CK1A2 0.703 0.053 -3 0.419
TLK1TLK1 0.702 -0.074 -2 0.673
GRK3GRK3 0.702 0.007 -2 0.619
GSK3BGSK3B 0.702 0.002 4 0.468
MAP3K15MAP3K15 0.702 -0.002 1 0.681
MARK2MARK2 0.702 -0.088 4 0.679
BUB1BUB1 0.702 0.010 -5 0.741
PAK5PAK5 0.701 -0.046 -2 0.515
MST1MST1 0.701 0.052 1 0.721
AKT3AKT3 0.701 0.003 -3 0.583
CAMKK1CAMKK1 0.701 -0.118 -2 0.653
SLKSLK 0.701 -0.011 -2 0.572
CDK6CDK6 0.701 -0.003 1 0.546
P70S6KP70S6K 0.701 -0.048 -3 0.649
TTBK1TTBK1 0.700 -0.067 2 0.530
PINK1PINK1 0.700 -0.169 1 0.681
BMPR2_TYRBMPR2_TYR 0.700 0.298 -1 0.437
ROCK2ROCK2 0.700 0.008 -3 0.745
MARK1MARK1 0.699 -0.090 4 0.742
YSK1YSK1 0.699 0.003 2 0.773
MEKK6MEKK6 0.699 -0.042 1 0.656
LRRK2LRRK2 0.699 -0.062 2 0.763
CAMK1DCAMK1D 0.699 -0.034 -3 0.643
DYRK1ADYRK1A 0.698 -0.053 1 0.637
MRCKBMRCKB 0.698 0.001 -3 0.687
CK1G1CK1G1 0.697 -0.014 -3 0.476
NEK1NEK1 0.697 -0.061 1 0.705
PDHK3_TYRPDHK3_TYR 0.697 0.051 4 0.847
LKB1LKB1 0.697 -0.109 -3 0.765
CK2A1CK2A1 0.697 0.058 1 0.541
CDK4CDK4 0.696 -0.020 1 0.528
PAK4PAK4 0.695 -0.047 -2 0.509
SGK1SGK1 0.695 -0.007 -3 0.566
DAPK3DAPK3 0.695 -0.037 -3 0.754
VRK1VRK1 0.695 -0.055 2 0.764
TESK1_TYRTESK1_TYR 0.695 0.049 3 0.818
DYRK3DYRK3 0.695 -0.048 1 0.619
DYRK1BDYRK1B 0.694 -0.045 1 0.563
PLK2PLK2 0.693 0.003 -3 0.765
CAMKK2CAMKK2 0.693 -0.143 -2 0.634
CHK2CHK2 0.693 -0.022 -3 0.588
MAKMAK 0.693 -0.018 -2 0.569
PDHK4_TYRPDHK4_TYR 0.693 0.090 2 0.785
MRCKAMRCKA 0.692 -0.017 -3 0.708
P38DP38D 0.692 -0.036 1 0.481
DYRK4DYRK4 0.692 -0.040 1 0.537
MOKMOK 0.692 -0.027 1 0.614
CAMK1ACAMK1A 0.691 -0.023 -3 0.611
OSR1OSR1 0.690 0.028 2 0.751
STK33STK33 0.690 -0.088 2 0.519
MYO3AMYO3A 0.690 0.054 1 0.720
JNK1JNK1 0.690 -0.026 1 0.527
DAPK1DAPK1 0.690 -0.030 -3 0.724
DMPK1DMPK1 0.690 0.012 -3 0.713
RIPK2RIPK2 0.689 -0.090 1 0.680
LIMK2_TYRLIMK2_TYR 0.688 -0.031 -3 0.841
PINK1_TYRPINK1_TYR 0.687 0.015 1 0.709
EPHA6EPHA6 0.687 0.163 -1 0.421
TAO1TAO1 0.687 -0.001 1 0.675
ROCK1ROCK1 0.687 -0.005 -3 0.705
PKMYT1_TYRPKMYT1_TYR 0.687 -0.045 3 0.790
MYO3BMYO3B 0.687 -0.003 2 0.783
LCKLCK 0.687 0.199 -1 0.424
PDHK1_TYRPDHK1_TYR 0.687 0.082 -1 0.370
ALPHAK3ALPHAK3 0.686 0.039 -1 0.315
MAP2K7_TYRMAP2K7_TYR 0.686 -0.058 2 0.769
MAP2K6_TYRMAP2K6_TYR 0.686 0.009 -1 0.340
MAP2K4_TYRMAP2K4_TYR 0.684 -0.101 -1 0.313
MEK2MEK2 0.682 -0.160 2 0.730
PBKPBK 0.682 -0.074 1 0.611
TTKTTK 0.682 -0.028 -2 0.630
PKG1PKG1 0.681 -0.050 -2 0.492
NEK3NEK3 0.681 -0.124 1 0.676
FYNFYN 0.681 0.215 -1 0.459
HCKHCK 0.681 0.125 -1 0.393
LIMK1_TYRLIMK1_TYR 0.680 -0.102 2 0.788
BLKBLK 0.680 0.150 -1 0.421
RETRET 0.680 -0.044 1 0.697
JAK3JAK3 0.679 0.097 1 0.676
TYK2TYK2 0.679 -0.034 1 0.699
ASK1ASK1 0.679 -0.041 1 0.673
MST1RMST1R 0.678 -0.011 3 0.724
ABL2ABL2 0.678 -0.024 -1 0.295
CSF1RCSF1R 0.677 -0.018 3 0.718
TXKTXK 0.677 0.061 1 0.636
YES1YES1 0.677 -0.015 -1 0.323
CRIKCRIK 0.676 -0.027 -3 0.664
NEK10_TYRNEK10_TYR 0.676 -0.020 1 0.660
SBKSBK 0.676 -0.044 -3 0.534
WEE1_TYRWEE1_TYR 0.676 -0.011 -1 0.265
BIKEBIKE 0.676 -0.038 1 0.580
ROS1ROS1 0.675 -0.050 3 0.704
EPHB4EPHB4 0.675 -0.002 -1 0.345
JAK2JAK2 0.675 -0.028 1 0.696
TYRO3TYRO3 0.675 -0.106 3 0.733
PTK2PTK2 0.674 0.237 -1 0.544
INSRRINSRR 0.673 0.029 3 0.673
SYKSYK 0.673 0.240 -1 0.480
ITKITK 0.673 0.018 -1 0.347
ABL1ABL1 0.673 -0.058 -1 0.282
JAK1JAK1 0.672 0.002 1 0.689
KDRKDR 0.672 0.029 3 0.677
FGRFGR 0.671 -0.034 1 0.665
BMXBMX 0.671 0.010 -1 0.323
METMET 0.670 0.057 3 0.686
KITKIT 0.670 -0.018 3 0.718
FLT1FLT1 0.668 0.083 -1 0.404
EPHA4EPHA4 0.668 0.019 2 0.654
TNK1TNK1 0.667 -0.115 3 0.720
CK1ACK1A 0.667 0.016 -3 0.338
TECTEC 0.667 -0.065 -1 0.267
FLT3FLT3 0.667 -0.045 3 0.734
DDR1DDR1 0.666 -0.143 4 0.773
SRMSSRMS 0.665 -0.057 1 0.669
LYNLYN 0.665 0.063 3 0.666
FERFER 0.665 -0.100 1 0.679
TNNI3K_TYRTNNI3K_TYR 0.665 -0.101 1 0.655
PDGFRBPDGFRB 0.664 -0.121 3 0.728
BTKBTK 0.664 -0.088 -1 0.282
STLK3STLK3 0.664 -0.067 1 0.650
EPHB2EPHB2 0.664 -0.005 -1 0.351
FGFR2FGFR2 0.664 -0.063 3 0.704
YANK3YANK3 0.664 -0.046 2 0.313
ERBB2ERBB2 0.664 0.024 1 0.646
EPHB1EPHB1 0.664 -0.040 1 0.666
FRKFRK 0.664 0.048 -1 0.375
TNK2TNK2 0.662 -0.125 3 0.652
SRCSRC 0.662 0.058 -1 0.384
EPHB3EPHB3 0.661 -0.041 -1 0.340
AAK1AAK1 0.661 -0.030 1 0.493
MERTKMERTK 0.659 -0.119 3 0.685
PDGFRAPDGFRA 0.659 -0.126 3 0.738
EPHA7EPHA7 0.658 0.000 2 0.660
ALKALK 0.658 -0.106 3 0.650
FGFR1FGFR1 0.658 -0.112 3 0.677
AXLAXL 0.657 -0.162 3 0.673
FGFR3FGFR3 0.657 -0.032 3 0.675
TEKTEK 0.657 -0.084 3 0.669
EPHA3EPHA3 0.656 -0.030 2 0.627
ZAP70ZAP70 0.656 0.112 -1 0.422
EPHA1EPHA1 0.656 -0.049 3 0.660
PTK6PTK6 0.656 -0.171 -1 0.240
FLT4FLT4 0.655 -0.054 3 0.687
LTKLTK 0.655 -0.127 3 0.670
EPHA8EPHA8 0.654 0.057 -1 0.411
EGFREGFR 0.654 -0.002 1 0.549
INSRINSR 0.653 -0.075 3 0.650
MATKMATK 0.651 -0.099 -1 0.262
NTRK2NTRK2 0.651 -0.140 3 0.678
NTRK1NTRK1 0.651 -0.142 -1 0.289
CK1G3CK1G3 0.650 -0.008 -3 0.292
DDR2DDR2 0.650 -0.094 3 0.644
ERBB4ERBB4 0.650 0.083 1 0.550
EPHA5EPHA5 0.650 -0.024 2 0.643
PTK2BPTK2B 0.647 -0.114 -1 0.269
FGFR4FGFR4 0.647 -0.063 -1 0.295
NTRK3NTRK3 0.647 -0.123 -1 0.262
MUSKMUSK 0.647 -0.063 1 0.543
EPHA2EPHA2 0.646 0.041 -1 0.405
CK1G2CK1G2 0.646 0.078 -3 0.388
CSKCSK 0.645 -0.108 2 0.661
IGF1RIGF1R 0.642 -0.037 3 0.599
YANK2YANK2 0.640 -0.048 2 0.347
FESFES 0.629 -0.095 -1 0.285