Motif 407 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKD9 | CCDC85C | S207 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| A6NKD9 | CCDC85C | S210 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| K7EQG2 | None | S46 | ochoa | Uncharacterized protein | None |
| O15061 | SYNM | S1211 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15164 | TRIM24 | S687 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15211 | RGL2 | S737 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15355 | PPM1G | S216 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43164 | PJA2 | S429 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43639 | NCK2 | S277 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
| O43822 | CFAP410 | S166 | ochoa | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}. |
| O60238 | BNIP3L | S64 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| O60260 | PRKN | S109 | psp | E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:29311685, PubMed:32047033). Substrates include SYT11 and VDAC1 (PubMed:29311685, PubMed:32047033). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25474007, PubMed:25621951, PubMed:32047033). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:15728840, PubMed:19229105). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:11439185, PubMed:18957282, PubMed:19029340, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24660806, PubMed:24784582, PubMed:24896179, PubMed:25474007, PubMed:25527291, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:11439185, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291, PubMed:32047033, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:24784582, PubMed:25474007, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:27534820, PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:10973942, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12150907, ECO:0000269|PubMed:12628165, ECO:0000269|PubMed:12719539, ECO:0000269|PubMed:15105460, ECO:0000269|PubMed:15728840, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23685073, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:33499712}. |
| O60346 | PHLPP1 | S321 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O75420 | GIGYF1 | S412 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O94887 | FARP2 | S340 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95782 | AP2A1 | S637 | ochoa | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P04083 | ANXA1 | S28 | ochoa|psp | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04626 | ERBB2 | S1051 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P07737 | PFN1 | S58 | ochoa | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| P08047 | SP1 | S46 | ochoa | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08240 | SRPRA | S297 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P08727 | KRT19 | S57 | ochoa | Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19) | Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P0CG40 | SP9 | S55 | ochoa | Transcription factor Sp9 | Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). {ECO:0000250}. |
| P10588 | NR2F6 | S143 | ochoa | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}. |
| P11274 | BCR | S236 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P11274 | BCR | S239 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P11362 | FGFR1 | S786 | ochoa | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P13693 | TPT1 | S64 | psp | Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) | Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}. |
| P15884 | TCF4 | S55 | psp | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P23677 | ITPKA | S124 | ochoa | Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO:0000269|PubMed:1847047}. |
| P28290 | ITPRID2 | S98 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P30260 | CDC27 | S435 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P35414 | APLNR | S348 | ochoa|psp | Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) | G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:11090199, PubMed:22810587, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:11090199, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G-protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy (PubMed:22810587, PubMed:38428423). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587, PubMed:38428423). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). {ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199, ECO:0000269|PubMed:22810587, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936, ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199). {ECO:0000269|PubMed:11090199}. |
| P36915 | GNL1 | S34 | ochoa | Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) | Possible regulatory or functional link with the histocompatibility cluster. |
| P38159 | RBMX | S174 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38159 | RBMX | S314 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P39019 | RPS19 | S90 | ochoa | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P43119 | PTGIR | S367 | ochoa | Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) | Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. |
| P48444 | ARCN1 | S189 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P48730 | CSNK1D | S383 | ochoa | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49023 | PXN | S84 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49023 | PXN | S320 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49023 | PXN | S321 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49674 | CSNK1E | S390 | ochoa | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}. |
| P49768 | PSEN1 | S366 | ochoa|psp | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| P53814 | SMTN | S714 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P57060 | RWDD2B | S172 | ochoa | RWD domain-containing protein 2B | None |
| P61978 | HNRNPK | Y380 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| Q03431 | PTH1R | S492 | psp | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}. |
| Q08495 | DMTN | S289 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q12888 | TP53BP1 | S1354 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12929 | EPS8 | S661 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13283 | G3BP1 | S39 | ochoa | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q13613 | MTMR1 | S646 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}. |
| Q14004 | CDK13 | S1153 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14155 | ARHGEF7 | S153 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14699 | RFTN1 | S168 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14980 | NUMA1 | S1789 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15648 | MED1 | S771 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q2M3G4 | SHROOM1 | S249 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q5BKZ1 | ZNF326 | S118 | ochoa | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q5FWE3 | PRRT3 | S768 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5T0Z8 | C6orf132 | S1088 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5VY43 | PEAR1 | S796 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q63ZY3 | KANK2 | S426 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q6P3S6 | FBXO42 | S584 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PKG0 | LARP1 | S850 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q7L5D6 | GET4 | S309 | ochoa | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}. |
| Q7Z5J4 | RAI1 | S1248 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6Z7 | HUWE1 | S2526 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86X29 | LSR | S365 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86YV5 | PRAG1 | Y864 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IY26 | PLPP6 | S20 | ochoa | Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase) | Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354). {ECO:0000269|PubMed:16464866, ECO:0000269|PubMed:18930839, ECO:0000269|PubMed:19220020, ECO:0000269|PubMed:20110354, ECO:0000269|PubMed:23568778}. |
| Q8IZ83 | ALDH16A1 | S551 | ochoa | Aldehyde dehydrogenase family 16 member A1 | None |
| Q8N3F8 | MICALL1 | S559 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N568 | DCLK2 | S362 | ochoa | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q8NE01 | CNNM3 | S689 | ochoa | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | Probable metal transporter. {ECO:0000250}. |
| Q8NFH8 | REPS2 | S240 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8NHG8 | ZNRF2 | S107 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8NHV4 | NEDD1 | S397 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8WUZ0 | BCL7C | S100 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
| Q8WVV9 | HNRNPLL | S285 | ochoa | Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
| Q92614 | MYO18A | S103 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92804 | TAF15 | S94 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q92974 | ARHGEF2 | S941 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q92997 | DVL3 | S567 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q93052 | LPP | S240 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q96E39 | RBMXL1 | S314 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96KQ7 | EHMT2 | S119 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96PU5 | NEDD4L | S366 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q99081 | TCF12 | Y70 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99501 | GAS2L1 | S600 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q9BPU6 | DPYSL5 | S532 | ochoa | Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) | Involved in the negative regulation of dendrite outgrowth. {ECO:0000269|PubMed:33894126}. |
| Q9BRR8 | GPATCH1 | S200 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BWH6 | RPAP1 | S201 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BXB4 | OSBPL11 | S41 | ochoa | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) | Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956, ECO:0000269|PubMed:39106189}. |
| Q9BZ67 | FRMD8 | S21 | ochoa | FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}. |
| Q9BZ68 | FRMD8P1 | S21 | ochoa | Putative FERM domain-containing protein FRMD8P1 (FERM domain-containing 8 pseudogene 1) | None |
| Q9C0D6 | FHDC1 | S723 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9C0J8 | WDR33 | S1277 | ochoa | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. |
| Q9H4A3 | WNK1 | S31 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H6U6 | BCAS3 | S894 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H7S9 | ZNF703 | S214 | ochoa | Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) | Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}. |
| Q9H7S9 | ZNF703 | S215 | ochoa | Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) | Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}. |
| Q9HB19 | PLEKHA2 | S321 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9NRH2 | SNRK | S570 | ochoa | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}. |
| Q9NV70 | EXOC1 | S464 | ochoa | Exocyst complex component 1 (Exocyst complex component Sec3) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}. |
| Q9NXR1 | NDE1 | S225 | ochoa | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
| Q9NZB2 | FAM120A | S507 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P258 | RCC2 | S43 | ochoa | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}. |
| Q9P258 | RCC2 | S44 | ochoa | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}. |
| Q9UBC2 | EPS15L1 | S715 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UGP4 | LIMD1 | S240 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UJY4 | GGA2 | S401 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| Q9UKI8 | TLK1 | S94 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9ULJ7 | ANKRD50 | S1138 | ochoa | Ankyrin repeat domain-containing protein 50 | Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). |
| Q9UNZ2 | NSFL1C | S59 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPU7 | TBC1D2B | S322 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9Y2I9 | TBC1D30 | S118 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
| Q9Y446 | PKP3 | S222 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4F3 | MARF1 | S951 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q9Y5P4 | CERT1 | S126 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q13347 | EIF3I | S302 | Sugiyama | Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q9H1R3 | MYLK2 | S73 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.000001 | 5.954 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.000004 | 5.389 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.000072 | 4.144 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 0.000836 | 3.078 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.000866 | 3.063 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.000993 | 3.003 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.001148 | 2.940 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.001392 | 2.856 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.003079 | 2.512 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.003079 | 2.512 |
| R-HSA-9839394 | TGFBR3 expression | 0.002318 | 2.635 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.003565 | 2.448 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.004636 | 2.334 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.004896 | 2.310 |
| R-HSA-380287 | Centrosome maturation | 0.005330 | 2.273 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.004688 | 2.329 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.004101 | 2.387 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 0.007126 | 2.147 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.008064 | 2.093 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.007600 | 2.119 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.007768 | 2.110 |
| R-HSA-68877 | Mitotic Prometaphase | 0.008958 | 2.048 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.009750 | 2.011 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.010781 | 1.967 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.024658 | 1.608 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.032742 | 1.485 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.032742 | 1.485 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.032742 | 1.485 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.032742 | 1.485 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.032742 | 1.485 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.032742 | 1.485 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.032742 | 1.485 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.032742 | 1.485 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.032742 | 1.485 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.032742 | 1.485 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.032742 | 1.485 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.040760 | 1.390 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.040760 | 1.390 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.048711 | 1.312 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.048711 | 1.312 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 0.056598 | 1.247 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.064419 | 1.191 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.079870 | 1.098 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.079870 | 1.098 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.014761 | 1.831 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.087500 | 1.058 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.023151 | 1.635 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.026293 | 1.580 |
| R-HSA-428540 | Activation of RAC1 | 0.117397 | 0.930 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.027925 | 1.554 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.124718 | 0.904 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.139180 | 0.856 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.139180 | 0.856 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.139180 | 0.856 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.146321 | 0.835 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.153404 | 0.814 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.153404 | 0.814 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.046309 | 1.334 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.160429 | 0.795 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.160429 | 0.795 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.167396 | 0.776 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.167396 | 0.776 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.174305 | 0.759 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.174305 | 0.759 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.058948 | 1.230 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.181157 | 0.742 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.181157 | 0.742 |
| R-HSA-167161 | HIV Transcription Initiation | 0.063397 | 1.198 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.063397 | 1.198 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.187953 | 0.726 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.194693 | 0.711 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.201378 | 0.696 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.221102 | 0.655 |
| R-HSA-72649 | Translation initiation complex formation | 0.094784 | 1.023 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.099945 | 1.000 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.105184 | 0.978 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.240344 | 0.619 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.252908 | 0.597 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.259113 | 0.587 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.160993 | 0.793 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.184600 | 0.734 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.184600 | 0.734 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.220820 | 0.656 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.260639 | 0.584 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.048338 | 1.316 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.016047 | 1.795 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.023151 | 1.635 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.146321 | 0.835 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.072619 | 1.139 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.013522 | 1.869 |
| R-HSA-4641265 | Repression of WNT target genes | 0.124718 | 0.904 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.067955 | 1.168 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.066180 | 1.179 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.099945 | 1.000 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 0.087500 | 1.058 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.131979 | 0.879 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.153404 | 0.814 |
| R-HSA-9664420 | Killing mechanisms | 0.153404 | 0.814 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.167396 | 0.776 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.174305 | 0.759 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.063397 | 1.198 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.018444 | 1.734 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.259113 | 0.587 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.151353 | 0.820 |
| R-HSA-3928664 | Ephrin signaling | 0.016047 | 1.795 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.194693 | 0.711 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.194100 | 0.712 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.233983 | 0.631 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.079870 | 1.098 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.139180 | 0.856 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.240344 | 0.619 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.259113 | 0.587 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.032742 | 1.485 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.032742 | 1.485 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.064419 | 1.191 |
| R-HSA-5689877 | Josephin domain DUBs | 0.102572 | 0.989 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.102572 | 0.989 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.124718 | 0.904 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.131979 | 0.879 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.034844 | 1.458 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.153404 | 0.814 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.160429 | 0.795 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.221102 | 0.655 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.221102 | 0.655 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.056705 | 1.246 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.118591 | 0.926 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.238850 | 0.622 |
| R-HSA-182971 | EGFR downregulation | 0.038526 | 1.414 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.013632 | 1.865 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.187953 | 0.726 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.187953 | 0.726 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.089126 | 1.050 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.031691 | 1.499 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.153404 | 0.814 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.167396 | 0.776 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.163913 | 0.785 |
| R-HSA-4086400 | PCP/CE pathway | 0.035641 | 1.448 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.172728 | 0.763 |
| R-HSA-8964046 | VLDL clearance | 0.079870 | 1.098 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 0.087500 | 1.058 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.095067 | 1.022 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.095067 | 1.022 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.160429 | 0.795 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.074989 | 1.125 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.105184 | 0.978 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.259113 | 0.587 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.233983 | 0.631 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.092233 | 1.035 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.214582 | 0.668 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.227569 | 0.643 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.227569 | 0.643 |
| R-HSA-195721 | Signaling by WNT | 0.050711 | 1.295 |
| R-HSA-69239 | Synthesis of DNA | 0.260639 | 0.584 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.042350 | 1.373 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.071899 | 1.143 |
| R-HSA-167172 | Transcription of the HIV genome | 0.132397 | 0.878 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.124718 | 0.904 |
| R-HSA-69109 | Leading Strand Synthesis | 0.124718 | 0.904 |
| R-HSA-69091 | Polymerase switching | 0.124718 | 0.904 |
| R-HSA-373755 | Semaphorin interactions | 0.021917 | 1.659 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.039672 | 1.402 |
| R-HSA-190236 | Signaling by FGFR | 0.229976 | 0.638 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.227569 | 0.643 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.035784 | 1.446 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.077383 | 1.111 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.252908 | 0.597 |
| R-HSA-177929 | Signaling by EGFR | 0.016735 | 1.776 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.095067 | 1.022 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.064419 | 1.191 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.064419 | 1.191 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.095067 | 1.022 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.095067 | 1.022 |
| R-HSA-8964038 | LDL clearance | 0.023151 | 1.635 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.139180 | 0.856 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.146321 | 0.835 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.056766 | 1.246 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.187953 | 0.726 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.033635 | 1.473 |
| R-HSA-5617833 | Cilium Assembly | 0.031186 | 1.506 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.056766 | 1.246 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.246652 | 0.608 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.149399 | 0.826 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.149415 | 0.826 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.242221 | 0.616 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.131979 | 0.879 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.139180 | 0.856 |
| R-HSA-1181150 | Signaling by NODAL | 0.187953 | 0.726 |
| R-HSA-109704 | PI3K Cascade | 0.084708 | 1.072 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.227569 | 0.643 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.117674 | 0.929 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.061158 | 1.214 |
| R-HSA-1640170 | Cell Cycle | 0.154909 | 0.810 |
| R-HSA-373753 | Nephrin family interactions | 0.187953 | 0.726 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.187953 | 0.726 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.194693 | 0.711 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.201378 | 0.696 |
| R-HSA-68886 | M Phase | 0.052275 | 1.282 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.102572 | 0.989 |
| R-HSA-525793 | Myogenesis | 0.029597 | 1.529 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.139180 | 0.856 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.146321 | 0.835 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.208007 | 0.682 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.099945 | 1.000 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.233983 | 0.631 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.107010 | 0.971 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.208971 | 0.680 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.099945 | 1.000 |
| R-HSA-69275 | G2/M Transition | 0.092823 | 1.032 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.039667 | 1.402 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.208007 | 0.682 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.095327 | 1.021 |
| R-HSA-9909396 | Circadian clock | 0.035831 | 1.446 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.065626 | 1.183 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.083581 | 1.078 |
| R-HSA-422475 | Axon guidance | 0.020359 | 1.691 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.079870 | 1.098 |
| R-HSA-162906 | HIV Infection | 0.151646 | 0.819 |
| R-HSA-977225 | Amyloid fiber formation | 0.169781 | 0.770 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.031308 | 1.504 |
| R-HSA-162587 | HIV Life Cycle | 0.179514 | 0.746 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.030672 | 1.513 |
| R-HSA-9675108 | Nervous system development | 0.029727 | 1.527 |
| R-HSA-8848021 | Signaling by PTK6 | 0.118591 | 0.926 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.118591 | 0.926 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.013522 | 1.869 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.110015 | 0.959 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.167396 | 0.776 |
| R-HSA-112399 | IRS-mediated signalling | 0.102555 | 0.989 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.259113 | 0.587 |
| R-HSA-2559583 | Cellular Senescence | 0.230634 | 0.637 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.226921 | 0.644 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.252908 | 0.597 |
| R-HSA-73884 | Base Excision Repair | 0.199597 | 0.700 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.017071 | 1.768 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.146321 | 0.835 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.167396 | 0.776 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.054425 | 1.264 |
| R-HSA-162582 | Signal Transduction | 0.025335 | 1.596 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.016047 | 1.795 |
| R-HSA-180292 | GAB1 signalosome | 0.174305 | 0.759 |
| R-HSA-445144 | Signal transduction by L1 | 0.187953 | 0.726 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.115876 | 0.936 |
| R-HSA-1266738 | Developmental Biology | 0.020347 | 1.691 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.174305 | 0.759 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.113177 | 0.946 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.208665 | 0.681 |
| R-HSA-9707616 | Heme signaling | 0.115876 | 0.936 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.052554 | 1.279 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.052838 | 1.277 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.138019 | 0.860 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.258954 | 0.587 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.187953 | 0.726 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.160993 | 0.793 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.248256 | 0.605 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.064784 | 1.189 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.130663 | 0.884 |
| R-HSA-5358508 | Mismatch Repair | 0.174305 | 0.759 |
| R-HSA-264876 | Insulin processing | 0.240344 | 0.619 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.121322 | 0.916 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.124069 | 0.906 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.098518 | 1.006 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.070274 | 1.153 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.152293 | 0.817 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.257567 | 0.589 |
| R-HSA-212436 | Generic Transcription Pathway | 0.235306 | 0.628 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.121322 | 0.916 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.187586 | 0.727 |
| R-HSA-1483255 | PI Metabolism | 0.242221 | 0.616 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.208665 | 0.681 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.256861 | 0.590 |
| R-HSA-73887 | Death Receptor Signaling | 0.173360 | 0.761 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.219474 | 0.659 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.187586 | 0.727 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.185728 | 0.731 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.205637 | 0.687 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.261607 | 0.582 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.263712 | 0.579 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.263712 | 0.579 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.263712 | 0.579 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.265266 | 0.576 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.265266 | 0.576 |
| R-HSA-186763 | Downstream signal transduction | 0.265266 | 0.576 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.266785 | 0.574 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.267801 | 0.572 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.269632 | 0.569 |
| R-HSA-69190 | DNA strand elongation | 0.271369 | 0.566 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.271369 | 0.566 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.271369 | 0.566 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.271369 | 0.566 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.277422 | 0.557 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.277422 | 0.557 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.277422 | 0.557 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.277422 | 0.557 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.281800 | 0.550 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.282145 | 0.550 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.283424 | 0.548 |
| R-HSA-72172 | mRNA Splicing | 0.286309 | 0.543 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.289377 | 0.539 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.289377 | 0.539 |
| R-HSA-5205647 | Mitophagy | 0.289377 | 0.539 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.289377 | 0.539 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.289377 | 0.539 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.289377 | 0.539 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.289377 | 0.539 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.291351 | 0.536 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.294416 | 0.531 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.294416 | 0.531 |
| R-HSA-373760 | L1CAM interactions | 0.294416 | 0.531 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.295281 | 0.530 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.297480 | 0.527 |
| R-HSA-5693538 | Homology Directed Repair | 0.300542 | 0.522 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.301137 | 0.521 |
| R-HSA-1500931 | Cell-Cell communication | 0.306683 | 0.513 |
| R-HSA-4641258 | Degradation of DVL | 0.306944 | 0.513 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.306944 | 0.513 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.306944 | 0.513 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.309715 | 0.509 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.312703 | 0.505 |
| R-HSA-68882 | Mitotic Anaphase | 0.313465 | 0.504 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.315733 | 0.501 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.318415 | 0.497 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.318415 | 0.497 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.318415 | 0.497 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.318415 | 0.497 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.318864 | 0.496 |
| R-HSA-199991 | Membrane Trafficking | 0.323035 | 0.491 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.324079 | 0.489 |
| R-HSA-9646399 | Aggrephagy | 0.324079 | 0.489 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.324079 | 0.489 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.324079 | 0.489 |
| R-HSA-194138 | Signaling by VEGF | 0.324948 | 0.488 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.329697 | 0.482 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.329697 | 0.482 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.334048 | 0.476 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.335268 | 0.475 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.340693 | 0.468 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.340794 | 0.468 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.340794 | 0.468 |
| R-HSA-73928 | Depyrimidination | 0.340794 | 0.468 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.340794 | 0.468 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.346274 | 0.461 |
| R-HSA-8854214 | TBC/RABGAPs | 0.346274 | 0.461 |
| R-HSA-72312 | rRNA processing | 0.349761 | 0.456 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.355559 | 0.449 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.357098 | 0.447 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.357098 | 0.447 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.357098 | 0.447 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.362444 | 0.441 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.364109 | 0.439 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.364987 | 0.438 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.367745 | 0.434 |
| R-HSA-437239 | Recycling pathway of L1 | 0.367745 | 0.434 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.373002 | 0.428 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.373002 | 0.428 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.373032 | 0.428 |
| R-HSA-73893 | DNA Damage Bypass | 0.378216 | 0.422 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.384851 | 0.415 |
| R-HSA-4839726 | Chromatin organization | 0.388114 | 0.411 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.388516 | 0.411 |
| R-HSA-74160 | Gene expression (Transcription) | 0.390643 | 0.408 |
| R-HSA-72187 | mRNA 3'-end processing | 0.393602 | 0.405 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.393602 | 0.405 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.398646 | 0.399 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.398646 | 0.399 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.399490 | 0.398 |
| R-HSA-69242 | S Phase | 0.402399 | 0.395 |
| R-HSA-166520 | Signaling by NTRKs | 0.402399 | 0.395 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.403648 | 0.394 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.403648 | 0.394 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.403648 | 0.394 |
| R-HSA-9758941 | Gastrulation | 0.405301 | 0.392 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.408609 | 0.389 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.408609 | 0.389 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.413529 | 0.383 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.413529 | 0.383 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.413529 | 0.383 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.416843 | 0.380 |
| R-HSA-69306 | DNA Replication | 0.416843 | 0.380 |
| R-HSA-1989781 | PPARA activates gene expression | 0.422572 | 0.374 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.423248 | 0.373 |
| R-HSA-180786 | Extension of Telomeres | 0.428047 | 0.369 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.428047 | 0.369 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.428272 | 0.368 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.432807 | 0.364 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.432807 | 0.364 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.432807 | 0.364 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.432807 | 0.364 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.432807 | 0.364 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.432807 | 0.364 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.432807 | 0.364 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.432807 | 0.364 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.432807 | 0.364 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.437527 | 0.359 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.437527 | 0.359 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.442208 | 0.354 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.442208 | 0.354 |
| R-HSA-186797 | Signaling by PDGF | 0.442208 | 0.354 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.446851 | 0.350 |
| R-HSA-446728 | Cell junction organization | 0.452144 | 0.345 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.456021 | 0.341 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.456021 | 0.341 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.460550 | 0.337 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.465041 | 0.333 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.465041 | 0.333 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.469495 | 0.328 |
| R-HSA-5218859 | Regulated Necrosis | 0.469495 | 0.328 |
| R-HSA-418555 | G alpha (s) signalling events | 0.470055 | 0.328 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.475489 | 0.323 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.475489 | 0.323 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.478293 | 0.320 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.478293 | 0.320 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.480891 | 0.318 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.482637 | 0.316 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.482637 | 0.316 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.482637 | 0.316 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.482637 | 0.316 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.486946 | 0.313 |
| R-HSA-9824446 | Viral Infection Pathways | 0.487697 | 0.312 |
| R-HSA-4086398 | Ca2+ pathway | 0.491219 | 0.309 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.491219 | 0.309 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.491219 | 0.309 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.495456 | 0.305 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.495456 | 0.305 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.495456 | 0.305 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.499659 | 0.301 |
| R-HSA-2262752 | Cellular responses to stress | 0.499805 | 0.301 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.503827 | 0.298 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.503827 | 0.298 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.509984 | 0.292 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.512059 | 0.291 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.512059 | 0.291 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.512059 | 0.291 |
| R-HSA-9659379 | Sensory processing of sound | 0.516124 | 0.287 |
| R-HSA-983712 | Ion channel transport | 0.517733 | 0.286 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.524154 | 0.281 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.524154 | 0.281 |
| R-HSA-9679506 | SARS-CoV Infections | 0.525128 | 0.280 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.525402 | 0.280 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.528119 | 0.277 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.532052 | 0.274 |
| R-HSA-1280218 | Adaptive Immune System | 0.532332 | 0.274 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.535500 | 0.271 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.535952 | 0.271 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.535952 | 0.271 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.538650 | 0.269 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.539819 | 0.268 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.545536 | 0.263 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.547459 | 0.262 |
| R-HSA-8957322 | Metabolism of steroids | 0.547508 | 0.262 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.550372 | 0.259 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.551231 | 0.259 |
| R-HSA-156902 | Peptide chain elongation | 0.554973 | 0.256 |
| R-HSA-9663891 | Selective autophagy | 0.554973 | 0.256 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.562363 | 0.250 |
| R-HSA-6805567 | Keratinization | 0.562510 | 0.250 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.566012 | 0.247 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.569631 | 0.244 |
| R-HSA-8953854 | Metabolism of RNA | 0.572976 | 0.242 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.573220 | 0.242 |
| R-HSA-397014 | Muscle contraction | 0.576767 | 0.239 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.576767 | 0.239 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.576779 | 0.239 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.583809 | 0.234 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.587281 | 0.231 |
| R-HSA-418990 | Adherens junctions interactions | 0.590686 | 0.229 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.590724 | 0.229 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.590724 | 0.229 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.590724 | 0.229 |
| R-HSA-157579 | Telomere Maintenance | 0.594138 | 0.226 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.594138 | 0.226 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.595157 | 0.225 |
| R-HSA-3214847 | HATs acetylate histones | 0.600882 | 0.221 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.607515 | 0.216 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.610790 | 0.214 |
| R-HSA-192823 | Viral mRNA Translation | 0.614038 | 0.212 |
| R-HSA-73894 | DNA Repair | 0.615078 | 0.211 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.617259 | 0.210 |
| R-HSA-9833110 | RSV-host interactions | 0.620454 | 0.207 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.623622 | 0.205 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.626141 | 0.203 |
| R-HSA-418346 | Platelet homeostasis | 0.626764 | 0.203 |
| R-HSA-8939211 | ESR-mediated signaling | 0.632520 | 0.199 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.636034 | 0.197 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.640407 | 0.194 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.645076 | 0.190 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.645076 | 0.190 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.645076 | 0.190 |
| R-HSA-388396 | GPCR downstream signalling | 0.653328 | 0.185 |
| R-HSA-421270 | Cell-cell junction organization | 0.661180 | 0.180 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.665315 | 0.177 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.665315 | 0.177 |
| R-HSA-68875 | Mitotic Prophase | 0.673634 | 0.172 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.674025 | 0.171 |
| R-HSA-73886 | Chromosome Maintenance | 0.676362 | 0.170 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.676362 | 0.170 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.681748 | 0.166 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.684408 | 0.165 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.689662 | 0.161 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.689662 | 0.161 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.689662 | 0.161 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.693558 | 0.159 |
| R-HSA-114608 | Platelet degranulation | 0.694829 | 0.158 |
| R-HSA-69481 | G2/M Checkpoints | 0.694829 | 0.158 |
| R-HSA-9843745 | Adipogenesis | 0.707376 | 0.150 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.709824 | 0.149 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.709824 | 0.149 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.712251 | 0.147 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.724086 | 0.140 |
| R-HSA-72766 | Translation | 0.726138 | 0.139 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.726395 | 0.139 |
| R-HSA-1632852 | Macroautophagy | 0.733206 | 0.135 |
| R-HSA-1483257 | Phospholipid metabolism | 0.739739 | 0.131 |
| R-HSA-372790 | Signaling by GPCR | 0.744208 | 0.128 |
| R-HSA-500792 | GPCR ligand binding | 0.750938 | 0.124 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.754717 | 0.122 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.756771 | 0.121 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.758808 | 0.120 |
| R-HSA-9609507 | Protein localization | 0.760828 | 0.119 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.762832 | 0.118 |
| R-HSA-6798695 | Neutrophil degranulation | 0.763007 | 0.117 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.764818 | 0.116 |
| R-HSA-1643685 | Disease | 0.765368 | 0.116 |
| R-HSA-9612973 | Autophagy | 0.766788 | 0.115 |
| R-HSA-9610379 | HCMV Late Events | 0.768742 | 0.114 |
| R-HSA-9711097 | Cellular response to starvation | 0.770679 | 0.113 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.781271 | 0.107 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.781970 | 0.107 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.797880 | 0.098 |
| R-HSA-168255 | Influenza Infection | 0.809453 | 0.092 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.830557 | 0.081 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.840370 | 0.076 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.840370 | 0.076 |
| R-HSA-428157 | Sphingolipid metabolism | 0.841711 | 0.075 |
| R-HSA-5357801 | Programmed Cell Death | 0.848251 | 0.071 |
| R-HSA-5663205 | Infectious disease | 0.854585 | 0.068 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.872911 | 0.059 |
| R-HSA-418594 | G alpha (i) signalling events | 0.873940 | 0.059 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.885980 | 0.053 |
| R-HSA-157118 | Signaling by NOTCH | 0.887097 | 0.052 |
| R-HSA-9609646 | HCMV Infection | 0.896257 | 0.048 |
| R-HSA-5688426 | Deubiquitination | 0.900556 | 0.045 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.901394 | 0.045 |
| R-HSA-416476 | G alpha (q) signalling events | 0.907853 | 0.042 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.915340 | 0.038 |
| R-HSA-112316 | Neuronal System | 0.916611 | 0.038 |
| R-HSA-9658195 | Leishmania infection | 0.920218 | 0.036 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.920218 | 0.036 |
| R-HSA-382551 | Transport of small molecules | 0.924707 | 0.034 |
| R-HSA-1474244 | Extracellular matrix organization | 0.947824 | 0.023 |
| R-HSA-449147 | Signaling by Interleukins | 0.972658 | 0.012 |
| R-HSA-392499 | Metabolism of proteins | 0.987099 | 0.006 |
| R-HSA-556833 | Metabolism of lipids | 0.988808 | 0.005 |
| R-HSA-109582 | Hemostasis | 0.991656 | 0.004 |
| R-HSA-168256 | Immune System | 0.995531 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995598 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 0.996020 | 0.002 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.999141 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999295 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999982 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.794 | 0.218 | 2 | 0.762 |
GRK1 |
0.787 | 0.274 | -2 | 0.835 |
MOS |
0.785 | 0.315 | 1 | 0.755 |
CLK3 |
0.783 | 0.101 | 1 | 0.684 |
NDR2 |
0.781 | 0.070 | -3 | 0.839 |
CDC7 |
0.780 | 0.089 | 1 | 0.780 |
PIM3 |
0.779 | 0.096 | -3 | 0.844 |
BMPR1B |
0.777 | 0.225 | 1 | 0.828 |
RSK2 |
0.772 | 0.097 | -3 | 0.779 |
IKKB |
0.768 | 0.009 | -2 | 0.739 |
SKMLCK |
0.768 | 0.104 | -2 | 0.860 |
CLK2 |
0.766 | 0.131 | -3 | 0.772 |
RSK4 |
0.766 | 0.115 | -3 | 0.762 |
PRPK |
0.765 | -0.001 | -1 | 0.334 |
CAMK2G |
0.765 | 0.071 | 2 | 0.728 |
KIS |
0.765 | 0.047 | 1 | 0.533 |
NDR1 |
0.764 | 0.034 | -3 | 0.825 |
GRK6 |
0.764 | 0.114 | 1 | 0.759 |
P90RSK |
0.764 | 0.060 | -3 | 0.785 |
MTOR |
0.763 | -0.040 | 1 | 0.630 |
GCN2 |
0.763 | -0.067 | 2 | 0.709 |
GRK7 |
0.763 | 0.115 | 1 | 0.699 |
ACVR2B |
0.762 | 0.215 | -2 | 0.819 |
CAMK2B |
0.762 | 0.075 | 2 | 0.719 |
DSTYK |
0.762 | 0.007 | 2 | 0.764 |
CAMK2A |
0.762 | 0.088 | 2 | 0.749 |
PIM1 |
0.762 | 0.060 | -3 | 0.799 |
GRK5 |
0.761 | 0.016 | -3 | 0.833 |
CAMK1B |
0.761 | 0.049 | -3 | 0.837 |
RSK3 |
0.761 | 0.052 | -3 | 0.777 |
TGFBR1 |
0.761 | 0.139 | -2 | 0.825 |
AURC |
0.761 | 0.066 | -2 | 0.668 |
SRPK1 |
0.760 | 0.051 | -3 | 0.780 |
MAPKAPK2 |
0.760 | 0.060 | -3 | 0.749 |
RAF1 |
0.760 | -0.031 | 1 | 0.697 |
CDKL1 |
0.760 | 0.052 | -3 | 0.811 |
LATS2 |
0.760 | 0.007 | -5 | 0.776 |
TGFBR2 |
0.759 | 0.006 | -2 | 0.838 |
MSK1 |
0.758 | 0.100 | -3 | 0.772 |
P70S6KB |
0.758 | 0.062 | -3 | 0.789 |
BMPR1A |
0.758 | 0.170 | 1 | 0.801 |
PASK |
0.758 | 0.212 | -3 | 0.852 |
IKKA |
0.758 | -0.001 | -2 | 0.737 |
RIPK3 |
0.757 | 0.034 | 3 | 0.696 |
ACVR2A |
0.757 | 0.159 | -2 | 0.812 |
GRK4 |
0.757 | 0.010 | -2 | 0.861 |
PRKD1 |
0.757 | -0.009 | -3 | 0.815 |
BMPR2 |
0.757 | -0.036 | -2 | 0.871 |
GRK2 |
0.756 | 0.132 | -2 | 0.749 |
CK2A2 |
0.755 | 0.147 | 1 | 0.760 |
DAPK2 |
0.755 | 0.074 | -3 | 0.838 |
PKN3 |
0.755 | 0.023 | -3 | 0.813 |
HIPK4 |
0.755 | 0.010 | 1 | 0.596 |
ERK5 |
0.755 | -0.034 | 1 | 0.674 |
CDKL5 |
0.755 | 0.033 | -3 | 0.802 |
MST4 |
0.755 | -0.000 | 2 | 0.777 |
ATR |
0.754 | -0.029 | 1 | 0.653 |
PKACG |
0.754 | 0.027 | -2 | 0.729 |
PRKX |
0.754 | 0.086 | -3 | 0.702 |
PKACB |
0.754 | 0.078 | -2 | 0.673 |
CAMLCK |
0.754 | 0.050 | -2 | 0.839 |
NLK |
0.753 | -0.035 | 1 | 0.661 |
CAMK2D |
0.753 | -0.006 | -3 | 0.805 |
PRKD2 |
0.753 | 0.010 | -3 | 0.762 |
IKKE |
0.753 | -0.087 | 1 | 0.581 |
TBK1 |
0.753 | -0.113 | 1 | 0.583 |
DRAK1 |
0.753 | 0.160 | 1 | 0.795 |
ALK4 |
0.753 | 0.085 | -2 | 0.845 |
MSK2 |
0.753 | 0.048 | -3 | 0.772 |
ALK2 |
0.753 | 0.116 | -2 | 0.842 |
PKN2 |
0.752 | 0.031 | -3 | 0.815 |
NEK6 |
0.752 | -0.079 | -2 | 0.871 |
LATS1 |
0.752 | 0.064 | -3 | 0.850 |
DLK |
0.752 | 0.076 | 1 | 0.704 |
PDHK4 |
0.751 | -0.185 | 1 | 0.688 |
MLK1 |
0.751 | -0.033 | 2 | 0.693 |
SRPK3 |
0.751 | 0.048 | -3 | 0.759 |
PLK1 |
0.750 | 0.066 | -2 | 0.824 |
ICK |
0.750 | 0.016 | -3 | 0.835 |
SRPK2 |
0.750 | 0.039 | -3 | 0.712 |
GRK3 |
0.750 | 0.123 | -2 | 0.726 |
NIK |
0.749 | -0.044 | -3 | 0.841 |
CK2A1 |
0.749 | 0.155 | 1 | 0.755 |
NUAK2 |
0.749 | -0.026 | -3 | 0.823 |
WNK1 |
0.749 | -0.042 | -2 | 0.856 |
CK1E |
0.748 | 0.106 | -3 | 0.609 |
AURA |
0.748 | 0.070 | -2 | 0.664 |
CLK4 |
0.748 | 0.053 | -3 | 0.775 |
MASTL |
0.747 | -0.071 | -2 | 0.805 |
HUNK |
0.747 | -0.068 | 2 | 0.721 |
ATM |
0.747 | -0.030 | 1 | 0.601 |
MAPKAPK3 |
0.747 | -0.012 | -3 | 0.775 |
CHAK2 |
0.746 | -0.066 | -1 | 0.311 |
MYLK4 |
0.746 | 0.080 | -2 | 0.768 |
DYRK2 |
0.746 | 0.011 | 1 | 0.532 |
NEK7 |
0.746 | -0.125 | -3 | 0.788 |
PAK1 |
0.746 | 0.012 | -2 | 0.773 |
FAM20C |
0.746 | -0.019 | 2 | 0.465 |
BCKDK |
0.746 | -0.118 | -1 | 0.268 |
CDK1 |
0.746 | 0.013 | 1 | 0.533 |
HIPK2 |
0.745 | 0.026 | 1 | 0.462 |
DYRK4 |
0.745 | 0.048 | 1 | 0.485 |
PDHK1 |
0.744 | -0.196 | 1 | 0.656 |
AURB |
0.743 | 0.040 | -2 | 0.668 |
PKCD |
0.742 | -0.040 | 2 | 0.667 |
AKT2 |
0.742 | 0.062 | -3 | 0.709 |
ANKRD3 |
0.742 | -0.027 | 1 | 0.693 |
MLK3 |
0.742 | -0.037 | 2 | 0.630 |
CAMK4 |
0.741 | -0.030 | -3 | 0.794 |
ULK2 |
0.741 | -0.193 | 2 | 0.652 |
CDK7 |
0.741 | -0.039 | 1 | 0.542 |
HIPK1 |
0.741 | 0.027 | 1 | 0.549 |
CDK18 |
0.740 | -0.012 | 1 | 0.489 |
CLK1 |
0.740 | 0.030 | -3 | 0.744 |
PLK3 |
0.740 | -0.013 | 2 | 0.681 |
AMPKA1 |
0.740 | -0.074 | -3 | 0.829 |
MLK2 |
0.740 | -0.091 | 2 | 0.691 |
MLK4 |
0.740 | -0.024 | 2 | 0.607 |
PKCG |
0.740 | -0.026 | 2 | 0.626 |
TTBK2 |
0.739 | -0.096 | 2 | 0.598 |
RIPK1 |
0.739 | -0.076 | 1 | 0.638 |
YSK4 |
0.739 | -0.035 | 1 | 0.634 |
CK1D |
0.739 | 0.100 | -3 | 0.562 |
CK1A2 |
0.738 | 0.109 | -3 | 0.564 |
PIM2 |
0.738 | 0.045 | -3 | 0.752 |
SGK3 |
0.738 | 0.022 | -3 | 0.770 |
PKCB |
0.737 | -0.033 | 2 | 0.620 |
PKCA |
0.737 | -0.027 | 2 | 0.615 |
JNK2 |
0.736 | 0.002 | 1 | 0.493 |
PAK3 |
0.736 | -0.041 | -2 | 0.760 |
TLK2 |
0.736 | -0.055 | 1 | 0.613 |
MEK1 |
0.736 | -0.026 | 2 | 0.733 |
WNK3 |
0.736 | -0.181 | 1 | 0.631 |
CDK8 |
0.735 | -0.064 | 1 | 0.529 |
JNK3 |
0.735 | -0.010 | 1 | 0.521 |
DNAPK |
0.735 | -0.035 | 1 | 0.515 |
PKG2 |
0.734 | 0.015 | -2 | 0.658 |
PKR |
0.734 | -0.058 | 1 | 0.654 |
MNK2 |
0.734 | -0.048 | -2 | 0.777 |
AMPKA2 |
0.734 | -0.068 | -3 | 0.804 |
NEK9 |
0.734 | -0.187 | 2 | 0.716 |
PKACA |
0.734 | 0.051 | -2 | 0.615 |
MNK1 |
0.733 | -0.040 | -2 | 0.779 |
CDK13 |
0.733 | -0.050 | 1 | 0.512 |
PAK2 |
0.733 | -0.028 | -2 | 0.766 |
PRKD3 |
0.733 | -0.019 | -3 | 0.749 |
P38G |
0.733 | -0.015 | 1 | 0.445 |
CDK17 |
0.733 | -0.021 | 1 | 0.453 |
ULK1 |
0.732 | -0.175 | -3 | 0.753 |
MARK4 |
0.732 | -0.120 | 4 | 0.798 |
DAPK1 |
0.732 | 0.114 | -3 | 0.784 |
CDK19 |
0.732 | -0.054 | 1 | 0.496 |
PHKG1 |
0.732 | -0.057 | -3 | 0.806 |
CAMK1G |
0.732 | 0.021 | -3 | 0.753 |
GAK |
0.732 | 0.147 | 1 | 0.744 |
IRE1 |
0.732 | -0.131 | 1 | 0.604 |
MEKK3 |
0.731 | 0.023 | 1 | 0.658 |
P38B |
0.731 | -0.014 | 1 | 0.513 |
PKCZ |
0.731 | -0.077 | 2 | 0.652 |
DCAMKL1 |
0.731 | -0.021 | -3 | 0.779 |
P70S6K |
0.731 | 0.028 | -3 | 0.717 |
CDK5 |
0.731 | -0.036 | 1 | 0.561 |
DYRK1A |
0.731 | 0.004 | 1 | 0.562 |
TSSK2 |
0.730 | -0.095 | -5 | 0.820 |
CDK10 |
0.730 | 0.012 | 1 | 0.513 |
SMG1 |
0.730 | -0.084 | 1 | 0.592 |
MST3 |
0.730 | 0.032 | 2 | 0.740 |
P38A |
0.729 | -0.034 | 1 | 0.566 |
PLK4 |
0.729 | -0.081 | 2 | 0.530 |
ERK1 |
0.729 | -0.036 | 1 | 0.499 |
PLK2 |
0.729 | 0.043 | -3 | 0.759 |
DAPK3 |
0.729 | 0.078 | -3 | 0.796 |
CDK12 |
0.729 | -0.045 | 1 | 0.485 |
DYRK1B |
0.729 | 0.004 | 1 | 0.511 |
VRK2 |
0.729 | -0.135 | 1 | 0.680 |
CDK14 |
0.729 | -0.009 | 1 | 0.524 |
BRSK1 |
0.728 | -0.042 | -3 | 0.787 |
TSSK1 |
0.728 | -0.104 | -3 | 0.841 |
GSK3A |
0.727 | 0.046 | 4 | 0.490 |
CDK3 |
0.727 | -0.016 | 1 | 0.473 |
SMMLCK |
0.727 | 0.044 | -3 | 0.801 |
GSK3B |
0.727 | 0.042 | 4 | 0.481 |
PKCH |
0.726 | -0.064 | 2 | 0.596 |
PAK6 |
0.726 | -0.021 | -2 | 0.700 |
NIM1 |
0.726 | -0.146 | 3 | 0.677 |
NUAK1 |
0.726 | -0.080 | -3 | 0.781 |
DYRK3 |
0.726 | 0.021 | 1 | 0.536 |
MELK |
0.726 | -0.087 | -3 | 0.783 |
MAPKAPK5 |
0.725 | -0.055 | -3 | 0.731 |
CK1G1 |
0.725 | -0.009 | -3 | 0.617 |
TAO3 |
0.724 | -0.049 | 1 | 0.647 |
AKT1 |
0.724 | 0.029 | -3 | 0.720 |
MAK |
0.724 | 0.052 | -2 | 0.739 |
ZAK |
0.724 | -0.097 | 1 | 0.630 |
CDK16 |
0.723 | -0.021 | 1 | 0.462 |
CDK2 |
0.723 | -0.055 | 1 | 0.606 |
IRE2 |
0.723 | -0.141 | 2 | 0.592 |
CDK9 |
0.723 | -0.067 | 1 | 0.515 |
HIPK3 |
0.723 | -0.019 | 1 | 0.523 |
QSK |
0.722 | -0.082 | 4 | 0.767 |
PERK |
0.722 | -0.134 | -2 | 0.853 |
JNK1 |
0.722 | -0.005 | 1 | 0.501 |
AKT3 |
0.722 | 0.055 | -3 | 0.665 |
TLK1 |
0.722 | -0.078 | -2 | 0.848 |
GCK |
0.722 | 0.043 | 1 | 0.680 |
MEK5 |
0.721 | -0.113 | 2 | 0.700 |
PRP4 |
0.721 | -0.033 | -3 | 0.698 |
CHK1 |
0.721 | -0.107 | -3 | 0.801 |
BRAF |
0.721 | -0.099 | -4 | 0.763 |
ERK2 |
0.721 | -0.065 | 1 | 0.524 |
DCAMKL2 |
0.720 | -0.036 | -3 | 0.786 |
MPSK1 |
0.720 | -0.034 | 1 | 0.649 |
MEKK1 |
0.720 | -0.128 | 1 | 0.623 |
NEK11 |
0.720 | -0.020 | 1 | 0.653 |
SGK1 |
0.720 | 0.052 | -3 | 0.652 |
P38D |
0.719 | -0.021 | 1 | 0.433 |
NEK2 |
0.718 | -0.180 | 2 | 0.689 |
BRSK2 |
0.718 | -0.106 | -3 | 0.787 |
QIK |
0.718 | -0.140 | -3 | 0.795 |
CAMK1D |
0.717 | -0.004 | -3 | 0.698 |
MEKK2 |
0.717 | -0.107 | 2 | 0.673 |
WNK4 |
0.717 | -0.119 | -2 | 0.853 |
NEK5 |
0.717 | -0.144 | 1 | 0.650 |
CHAK1 |
0.717 | -0.187 | 2 | 0.630 |
SIK |
0.717 | -0.088 | -3 | 0.756 |
SNRK |
0.716 | -0.112 | 2 | 0.546 |
HRI |
0.716 | -0.176 | -2 | 0.846 |
CK1A |
0.715 | 0.086 | -3 | 0.488 |
MARK3 |
0.715 | -0.079 | 4 | 0.716 |
PAK4 |
0.715 | -0.011 | -2 | 0.669 |
HPK1 |
0.715 | 0.022 | 1 | 0.658 |
BMPR2_TYR |
0.715 | 0.414 | -1 | 0.451 |
PAK5 |
0.715 | -0.024 | -2 | 0.654 |
TAK1 |
0.714 | 0.041 | 1 | 0.683 |
PTK2 |
0.714 | 0.378 | -1 | 0.535 |
PKCE |
0.714 | -0.019 | 2 | 0.608 |
PKCT |
0.714 | -0.071 | 2 | 0.604 |
YANK3 |
0.712 | 0.025 | 2 | 0.378 |
TXK |
0.712 | 0.255 | 1 | 0.800 |
MST2 |
0.712 | -0.036 | 1 | 0.662 |
PKCI |
0.711 | -0.066 | 2 | 0.631 |
TTBK1 |
0.711 | -0.128 | 2 | 0.527 |
ROCK2 |
0.710 | 0.018 | -3 | 0.787 |
PDK1 |
0.710 | -0.064 | 1 | 0.644 |
ERK7 |
0.710 | -0.033 | 2 | 0.484 |
NEK8 |
0.710 | -0.131 | 2 | 0.682 |
MRCKB |
0.710 | 0.019 | -3 | 0.736 |
PDHK3_TYR |
0.709 | 0.187 | 4 | 0.912 |
MOK |
0.709 | 0.013 | 1 | 0.564 |
MRCKA |
0.709 | 0.011 | -3 | 0.752 |
IRAK4 |
0.709 | -0.172 | 1 | 0.599 |
PDHK4_TYR |
0.708 | 0.234 | 2 | 0.772 |
MARK2 |
0.708 | -0.113 | 4 | 0.679 |
MAP2K6_TYR |
0.708 | 0.235 | -1 | 0.364 |
LKB1 |
0.708 | -0.116 | -3 | 0.766 |
DMPK1 |
0.708 | 0.059 | -3 | 0.752 |
CAMKK1 |
0.707 | -0.144 | -2 | 0.734 |
MARK1 |
0.707 | -0.105 | 4 | 0.741 |
CHK2 |
0.707 | 0.008 | -3 | 0.654 |
PHKG2 |
0.707 | -0.087 | -3 | 0.762 |
TAO2 |
0.706 | -0.121 | 2 | 0.716 |
CAMKK2 |
0.706 | -0.125 | -2 | 0.727 |
EPHA6 |
0.706 | 0.254 | -1 | 0.421 |
PINK1 |
0.706 | -0.209 | 1 | 0.659 |
MINK |
0.705 | -0.073 | 1 | 0.633 |
PDHK1_TYR |
0.705 | 0.239 | -1 | 0.388 |
MAP3K15 |
0.704 | -0.106 | 1 | 0.608 |
FYN |
0.704 | 0.288 | -1 | 0.458 |
EEF2K |
0.704 | -0.078 | 3 | 0.695 |
TNIK |
0.704 | -0.084 | 3 | 0.732 |
MAP2K4_TYR |
0.703 | 0.119 | -1 | 0.336 |
IRAK1 |
0.703 | -0.196 | -1 | 0.241 |
CRIK |
0.703 | 0.052 | -3 | 0.725 |
KHS2 |
0.703 | -0.027 | 1 | 0.640 |
SSTK |
0.702 | -0.102 | 4 | 0.762 |
STK33 |
0.702 | -0.101 | 2 | 0.544 |
VRK1 |
0.702 | -0.084 | 2 | 0.700 |
SYK |
0.702 | 0.313 | -1 | 0.502 |
SLK |
0.702 | -0.080 | -2 | 0.697 |
PKN1 |
0.702 | -0.033 | -3 | 0.722 |
MEKK6 |
0.702 | -0.121 | 1 | 0.627 |
SBK |
0.701 | 0.015 | -3 | 0.602 |
PBK |
0.701 | -0.021 | 1 | 0.666 |
KHS1 |
0.701 | -0.059 | 1 | 0.612 |
LRRK2 |
0.701 | -0.135 | 2 | 0.721 |
MST1 |
0.701 | -0.093 | 1 | 0.634 |
EPHB4 |
0.700 | 0.135 | -1 | 0.347 |
OSR1 |
0.700 | -0.011 | 2 | 0.707 |
CAMK1A |
0.700 | -0.012 | -3 | 0.673 |
TTK |
0.700 | -0.008 | -2 | 0.859 |
ALPHAK3 |
0.699 | 0.030 | -1 | 0.346 |
BLK |
0.699 | 0.213 | -1 | 0.412 |
NEK4 |
0.698 | -0.186 | 1 | 0.599 |
HGK |
0.698 | -0.130 | 3 | 0.739 |
CDK6 |
0.698 | -0.064 | 1 | 0.496 |
LOK |
0.697 | -0.119 | -2 | 0.732 |
CDK4 |
0.697 | -0.062 | 1 | 0.473 |
LCK |
0.697 | 0.215 | -1 | 0.417 |
TESK1_TYR |
0.696 | 0.018 | 3 | 0.763 |
EPHA4 |
0.696 | 0.142 | 2 | 0.699 |
BMX |
0.696 | 0.123 | -1 | 0.334 |
ITK |
0.694 | 0.147 | -1 | 0.334 |
BUB1 |
0.694 | -0.055 | -5 | 0.782 |
PKMYT1_TYR |
0.694 | -0.015 | 3 | 0.751 |
FGR |
0.694 | 0.075 | 1 | 0.739 |
NEK1 |
0.693 | -0.189 | 1 | 0.614 |
ROCK1 |
0.693 | 0.003 | -3 | 0.750 |
SRMS |
0.693 | 0.106 | 1 | 0.756 |
MAP2K7_TYR |
0.693 | -0.037 | 2 | 0.732 |
HASPIN |
0.693 | -0.066 | -1 | 0.248 |
INSRR |
0.691 | 0.079 | 3 | 0.665 |
ABL2 |
0.691 | 0.003 | -1 | 0.305 |
EPHB2 |
0.691 | 0.115 | -1 | 0.345 |
HCK |
0.690 | 0.142 | -1 | 0.385 |
PINK1_TYR |
0.690 | -0.017 | 1 | 0.692 |
RIPK2 |
0.690 | -0.166 | 1 | 0.587 |
FLT1 |
0.689 | 0.149 | -1 | 0.415 |
YES1 |
0.689 | 0.030 | -1 | 0.322 |
YSK1 |
0.689 | -0.132 | 2 | 0.694 |
MET |
0.689 | 0.106 | 3 | 0.697 |
BIKE |
0.689 | -0.000 | 1 | 0.650 |
JAK3 |
0.689 | 0.098 | 1 | 0.627 |
EPHB1 |
0.689 | 0.096 | 1 | 0.732 |
PKG1 |
0.688 | -0.029 | -2 | 0.561 |
FER |
0.688 | 0.008 | 1 | 0.750 |
EPHB3 |
0.688 | 0.085 | -1 | 0.339 |
MEK2 |
0.688 | -0.214 | 2 | 0.688 |
EPHA7 |
0.687 | 0.119 | 2 | 0.681 |
ABL1 |
0.685 | -0.028 | -1 | 0.287 |
EPHA8 |
0.685 | 0.161 | -1 | 0.416 |
LIMK2_TYR |
0.685 | -0.087 | -3 | 0.831 |
MST1R |
0.685 | -0.038 | 3 | 0.714 |
CK1G2 |
0.684 | 0.108 | -3 | 0.534 |
EPHA5 |
0.684 | 0.105 | 2 | 0.671 |
KIT |
0.684 | 0.017 | 3 | 0.704 |
ZAP70 |
0.684 | 0.159 | -1 | 0.454 |
MERTK |
0.684 | 0.000 | 3 | 0.688 |
EPHA2 |
0.684 | 0.172 | -1 | 0.409 |
SRC |
0.683 | 0.121 | -1 | 0.384 |
PTK2B |
0.683 | 0.046 | -1 | 0.253 |
RET |
0.683 | -0.095 | 1 | 0.618 |
EPHA3 |
0.682 | 0.069 | 2 | 0.661 |
CSF1R |
0.682 | -0.044 | 3 | 0.703 |
ASK1 |
0.682 | -0.124 | 1 | 0.601 |
KDR |
0.682 | 0.032 | 3 | 0.680 |
FGFR2 |
0.681 | -0.008 | 3 | 0.725 |
TEC |
0.681 | -0.009 | -1 | 0.256 |
ERBB4 |
0.681 | 0.151 | 1 | 0.619 |
YANK2 |
0.680 | 0.008 | 2 | 0.382 |
TNK2 |
0.680 | -0.052 | 3 | 0.683 |
TYRO3 |
0.679 | -0.113 | 3 | 0.683 |
DDR1 |
0.678 | -0.094 | 4 | 0.829 |
FGFR3 |
0.678 | 0.031 | 3 | 0.701 |
LYN |
0.678 | 0.083 | 3 | 0.632 |
MYO3B |
0.677 | -0.121 | 2 | 0.692 |
ROS1 |
0.676 | -0.122 | 3 | 0.667 |
LIMK1_TYR |
0.676 | -0.192 | 2 | 0.705 |
ERBB2 |
0.676 | 0.031 | 1 | 0.636 |
EGFR |
0.676 | 0.036 | 1 | 0.568 |
NEK3 |
0.675 | -0.213 | 1 | 0.562 |
AAK1 |
0.674 | 0.011 | 1 | 0.571 |
NTRK1 |
0.674 | -0.064 | -1 | 0.314 |
FRK |
0.673 | 0.054 | -1 | 0.370 |
NTRK3 |
0.673 | -0.041 | -1 | 0.304 |
MYO3A |
0.673 | -0.122 | 1 | 0.584 |
JAK2 |
0.673 | -0.138 | 1 | 0.606 |
STLK3 |
0.673 | -0.104 | 1 | 0.585 |
TAO1 |
0.672 | -0.158 | 1 | 0.550 |
AXL |
0.672 | -0.099 | 3 | 0.694 |
TYK2 |
0.672 | -0.195 | 1 | 0.611 |
EPHA1 |
0.672 | 0.006 | 3 | 0.676 |
CK1G3 |
0.672 | 0.006 | -3 | 0.447 |
MATK |
0.671 | -0.047 | -1 | 0.284 |
FGFR4 |
0.670 | -0.008 | -1 | 0.314 |
WEE1_TYR |
0.670 | -0.072 | -1 | 0.282 |
TEK |
0.670 | -0.055 | 3 | 0.642 |
INSR |
0.669 | -0.048 | 3 | 0.643 |
PDGFRB |
0.668 | -0.148 | 3 | 0.698 |
FLT4 |
0.668 | -0.041 | 3 | 0.677 |
BTK |
0.668 | -0.103 | -1 | 0.274 |
LTK |
0.667 | -0.112 | 3 | 0.651 |
NEK10_TYR |
0.667 | -0.126 | 1 | 0.538 |
FGFR1 |
0.666 | -0.118 | 3 | 0.673 |
PTK6 |
0.666 | -0.156 | -1 | 0.247 |
IGF1R |
0.666 | 0.010 | 3 | 0.593 |
JAK1 |
0.665 | -0.112 | 1 | 0.565 |
FLT3 |
0.665 | -0.120 | 3 | 0.682 |
ALK |
0.665 | -0.121 | 3 | 0.625 |
DDR2 |
0.664 | -0.035 | 3 | 0.669 |
NTRK2 |
0.664 | -0.122 | 3 | 0.673 |
CSK |
0.663 | -0.058 | 2 | 0.678 |
TNK1 |
0.661 | -0.187 | 3 | 0.674 |
FES |
0.659 | 0.014 | -1 | 0.295 |
PDGFRA |
0.656 | -0.218 | 3 | 0.691 |
TNNI3K_TYR |
0.655 | -0.182 | 1 | 0.591 |
MUSK |
0.653 | -0.080 | 1 | 0.561 |