Motif 406 (n=138)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NI28 | ARHGAP42 | S600 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| A6NKT7 | RGPD3 | T1325 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O14639 | ABLIM1 | S353 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14733 | MAP2K7 | S58 | ochoa | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O15117 | FYB1 | S222 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15553 | MEFV | S209 | psp | Pyrin (Marenostrin) | Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:16037825, PubMed:16785446, PubMed:17431422, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:26347139, PubMed:27030597, PubMed:28835462). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). {ECO:0000250|UniProtKB:Q9JJ26, ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11468188, ECO:0000269|PubMed:16037825, ECO:0000269|PubMed:16785446, ECO:0000269|PubMed:17431422, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18577712, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:27030597, ECO:0000269|PubMed:28835462}. |
| O43304 | SEC14L5 | S202 | ochoa | SEC14-like protein 5 | None |
| O43581 | SYT7 | S103 | ochoa | Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) | Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}. |
| O60269 | GPRIN2 | S25 | ochoa | G protein-regulated inducer of neurite outgrowth 2 (GRIN2) | May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}. |
| O60563 | CCNT1 | S564 | ochoa|psp | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O75128 | COBL | S974 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75251 | NDUFS7 | S58 | ochoa | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 7.1.1.2) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit) | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:17275378). Essential for the catalytic activity of complex I (PubMed:17275378). {ECO:0000269|PubMed:17275378}. |
| O75533 | SF3B1 | S287 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O94761 | RECQL4 | S326 | ochoa | ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4) | An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction (PubMed:28653661). Does not unwind more than 18 bp of dsDNA (PubMed:28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed:22730300). The core helicase domain binds ssDNA (PubMed:22730300, PubMed:28653661). {ECO:0000269|PubMed:15317757, ECO:0000269|PubMed:22730300, ECO:0000269|PubMed:28653661}. |
| O94887 | FARP2 | S483 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O94913 | PCF11 | S182 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95503 | CBX6 | S276 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| O95785 | WIZ | S1219 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P04049 | RAF1 | S244 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P06127 | CD5 | S439 | ochoa | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
| P08913 | ADRA2A | S314 | psp | Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
| P0DJD0 | RGPD1 | T1309 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T1317 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P14317 | HCLS1 | S312 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P15923 | TCF3 | S189 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P27816 | MAP4 | S157 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30405 | PPIF | S40 | ochoa | Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:Q99KR7, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}. |
| P43243 | MATR3 | S276 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46821 | MAP1B | S1817 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S355 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49792 | RANBP2 | T2300 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50479 | PDLIM4 | S132 | ochoa | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) | [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269|PubMed:21636573}. |
| P51003 | PAPOLA | S629 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51798 | CLCN7 | S61 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P57682 | KLF3 | S81 | ochoa | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P78527 | PRKDC | S2675 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q00653 | NFKB2 | S727 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q03164 | KMT2A | S181 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q08999 | RBL2 | S972 | ochoa | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q12767 | TMEM94 | S444 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q13094 | LCP2 | S339 | ochoa | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q13112 | CHAF1B | S523 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13464 | ROCK1 | S1147 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q14157 | UBAP2L | S428 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14181 | POLA2 | S150 | ochoa | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:9705292}. |
| Q14676 | MDC1 | S1681 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14678 | KANK1 | S195 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q15003 | NCAPH | S28 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15004 | PCLAF | S40 | ochoa | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Q15047 | SETDB1 | S973 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15569 | TESK1 | S441 | ochoa | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q16584 | MAP3K11 | S556 | psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q49A26 | GLYR1 | S187 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q52LW3 | ARHGAP29 | S510 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53ET0 | CRTC2 | S490 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5BJF6 | ODF2 | S96 | ochoa | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}. |
| Q5BKZ1 | ZNF326 | S131 | ochoa | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q5SW79 | CEP170 | S270 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SY16 | NOL9 | S106 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5SYE7 | NHSL1 | S1470 | ochoa | NHS-like protein 1 | None |
| Q5T1M5 | FKBP15 | S1093 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5TCZ1 | SH3PXD2A | S544 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VWJ9 | SNX30 | S40 | ochoa | Sorting nexin-30 | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}. |
| Q676U5 | ATG16L1 | S290 | ochoa | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q6P2E9 | EDC4 | S586 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6ZRV2 | FAM83H | S514 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q76FK4 | NOL8 | S663 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q76N32 | CEP68 | S238 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7L2J0 | MEPCE | S358 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z3J3 | RGPD4 | T1325 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3K3 | POGZ | S720 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z3U7 | MON2 | S649 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q86VR2 | RETREG3 | S350 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q8IZ41 | RASEF | S406 | ochoa | Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) | Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). {ECO:0000269|PubMed:17448446, ECO:0000269|PubMed:30814157}. |
| Q8N3F8 | MICALL1 | S324 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4S9 | MARVELD2 | S146 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q8NAX2 | KDF1 | S158 | ochoa | Keratinocyte differentiation factor 1 | Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}. |
| Q8ND82 | ZNF280C | S115 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
| Q8NI08 | NCOA7 | S609 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TBP0 | TBC1D16 | S384 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TDX7 | NEK7 | S188 | ochoa | Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596, PubMed:19941817, PubMed:26522158, PubMed:31409757). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:36442502, PubMed:39173637). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26642356, PubMed:31189953, PubMed:36442502, PubMed:39173637). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:31189953). {ECO:0000250|UniProtKB:D3ZBE5, ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158, ECO:0000269|PubMed:26642356, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:31409757, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}. |
| Q8WU20 | FRS2 | S234 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WXX7 | AUTS2 | S959 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q93052 | LPP | S240 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q969S8 | HDAC10 | S371 | ochoa | Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}. |
| Q96D71 | REPS1 | Y116 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96D71 | REPS1 | S118 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96G42 | KLHDC7B | S142 | ochoa | Kelch domain-containing protein 7B | None |
| Q96JE7 | SEC16B | S234 | ochoa | Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) | Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21768384, ECO:0000303|PubMed:22355596}. |
| Q96JM3 | CHAMP1 | S244 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JT2 | SLC45A3 | S423 | ochoa | Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}. |
| Q96KQ4 | PPP1R13B | S478 | ochoa | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}. |
| Q96PD2 | DCBLD2 | S727 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) | None |
| Q96PN7 | TRERF1 | S1070 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96RN5 | MED15 | S517 | ochoa | Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}. |
| Q96T58 | SPEN | S2456 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99081 | TCF12 | S386 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99570 | PIK3R4 | S895 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99961 | SH3GL1 | S287 | ochoa | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
| Q9BQI5 | SGIP1 | S169 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BRD0 | BUD13 | S211 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BUR4 | WRAP53 | S74 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BW92 | TARS2 | S389 | ochoa | Threonine--tRNA ligase, mitochondrial (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. {ECO:0000269|PubMed:26811336}. |
| Q9BXL6 | CARD14 | S498 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9H165 | BCL11A | S628 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9H792 | PEAK1 | S1248 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H9A7 | RMI1 | S275 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9HC35 | EML4 | S888 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HC98 | NEK6 | S199 | ochoa | Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). {ECO:0000269|PubMed:11516946, ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361, ECO:0000269|PubMed:31409757}. |
| Q9NPG3 | UBN1 | S978 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQC1 | JADE2 | S120 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
| Q9NQS7 | INCENP | S312 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NUQ6 | SPATS2L | S117 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NY27 | PPP4R2 | S139 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9NYF8 | BCLAF1 | S320 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P0K1 | ADAM22 | S869 | ochoa | Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}. |
| Q9P0U4 | CXXC1 | S264 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9UER7 | DAXX | S697 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UGP4 | LIMD1 | S424 | ochoa|psp | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHB6 | LIMA1 | S541 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHV7 | MED13 | S557 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9ULJ3 | ZBTB21 | S144 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULT8 | HECTD1 | S252 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9ULV3 | CIZ1 | S200 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UMS6 | SYNPO2 | S330 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPU7 | TBC1D2B | S322 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9UQ35 | SRRM2 | S2429 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2E4 | DIP2C | S70 | ochoa | Disco-interacting protein 2 homolog C (DIP2 homolog C) | None |
| Q9Y3M8 | STARD13 | S334 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y3S1 | WNK2 | S1844 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y490 | TLN1 | S1164 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y6A5 | TACC3 | S188 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6K5 | OAS3 | S385 | ochoa | 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}. |
| P12277 | CKB | S129 | Sugiyama | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| Q09666 | AHNAK | S295 | Sugiyama | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q7RTN6 | STRADA | S47 | Sugiyama | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}. |
| Q8N568 | DCLK2 | S182 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q9UK32 | RPS6KA6 | S25 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.017971 | 1.745 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.017971 | 1.745 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.017971 | 1.745 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.017971 | 1.745 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.017971 | 1.745 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.026836 | 1.571 |
| R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 0.044328 | 1.353 |
| R-HSA-8941237 | Invadopodia formation | 0.044328 | 1.353 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.005474 | 2.262 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.061507 | 1.211 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.069982 | 1.155 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.086703 | 1.062 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.086703 | 1.062 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.086703 | 1.062 |
| R-HSA-444257 | RSK activation | 0.094952 | 1.022 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.094952 | 1.022 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.094952 | 1.022 |
| R-HSA-68952 | DNA replication initiation | 0.111227 | 0.954 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.006831 | 2.165 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.127212 | 0.895 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.127212 | 0.895 |
| R-HSA-69109 | Leading Strand Synthesis | 0.135097 | 0.869 |
| R-HSA-69091 | Polymerase switching | 0.135097 | 0.869 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.142912 | 0.845 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.013425 | 1.872 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.150656 | 0.822 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.165936 | 0.780 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.165936 | 0.780 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.180944 | 0.742 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.195683 | 0.708 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.073558 | 1.133 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.202953 | 0.693 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.202953 | 0.693 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.202953 | 0.693 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.202953 | 0.693 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.202953 | 0.693 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.202953 | 0.693 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.092295 | 1.035 |
| R-HSA-72187 | mRNA 3'-end processing | 0.103558 | 0.985 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.245226 | 0.610 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.258816 | 0.587 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.258816 | 0.587 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.265519 | 0.576 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.265519 | 0.576 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.272163 | 0.565 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.278746 | 0.555 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.142400 | 0.846 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.285271 | 0.545 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.285271 | 0.545 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.298144 | 0.526 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.298144 | 0.526 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.304495 | 0.516 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.209946 | 0.678 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.209946 | 0.678 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.210158 | 0.677 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.304579 | 0.516 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.252051 | 0.599 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.055875 | 1.253 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.013425 | 1.872 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.013425 | 1.872 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.158330 | 0.800 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.195683 | 0.708 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.202953 | 0.693 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.224375 | 0.649 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.245226 | 0.610 |
| R-HSA-1538133 | G0 and Early G1 | 0.291737 | 0.535 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.073558 | 1.133 |
| R-HSA-354192 | Integrin signaling | 0.298144 | 0.526 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.213252 | 0.671 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.053320 | 1.273 |
| R-HSA-5682910 | LGI-ADAM interactions | 0.119256 | 0.924 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.005157 | 2.288 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.013425 | 1.872 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.084103 | 1.075 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.217299 | 0.663 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.224375 | 0.649 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.245226 | 0.610 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.265519 | 0.576 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.158330 | 0.800 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.173474 | 0.761 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.135097 | 0.869 |
| R-HSA-4641265 | Repression of WNT target genes | 0.135097 | 0.869 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.298144 | 0.526 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.265519 | 0.576 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.304495 | 0.516 |
| R-HSA-5673000 | RAF activation | 0.053932 | 1.268 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.061045 | 1.214 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.210158 | 0.677 |
| R-HSA-69190 | DNA strand elongation | 0.291737 | 0.535 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.298144 | 0.526 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.298144 | 0.526 |
| R-HSA-202433 | Generation of second messenger molecules | 0.068459 | 1.165 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.047943 | 1.319 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.107563 | 0.968 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.205611 | 0.687 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.086703 | 1.062 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.015898 | 1.799 |
| R-HSA-68877 | Mitotic Prometaphase | 0.003397 | 2.469 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.202953 | 0.693 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.059757 | 1.224 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.266601 | 0.574 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.272163 | 0.565 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.278746 | 0.555 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.317024 | 0.499 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.071104 | 1.148 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.310788 | 0.508 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.317024 | 0.499 |
| R-HSA-2424491 | DAP12 signaling | 0.278746 | 0.555 |
| R-HSA-5693538 | Homology Directed Repair | 0.119100 | 0.924 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.253216 | 0.597 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.003134 | 2.504 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.014505 | 1.838 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.158330 | 0.800 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.224375 | 0.649 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.238338 | 0.623 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.130130 | 0.886 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.304495 | 0.516 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.310788 | 0.508 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.310788 | 0.508 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.329330 | 0.482 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.310018 | 0.509 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.150656 | 0.822 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.051949 | 1.284 |
| R-HSA-157579 | Telomere Maintenance | 0.075895 | 1.120 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.201839 | 0.695 |
| R-HSA-182971 | EGFR downregulation | 0.285271 | 0.545 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.086703 | 1.062 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.056268 | 1.250 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.291737 | 0.535 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.304495 | 0.516 |
| R-HSA-73886 | Chromosome Maintenance | 0.125035 | 0.903 |
| R-HSA-180786 | Extension of Telomeres | 0.124094 | 0.906 |
| R-HSA-170968 | Frs2-mediated activation | 0.142912 | 0.845 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.069982 | 1.155 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.127212 | 0.895 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.173474 | 0.761 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.252051 | 0.599 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.258816 | 0.587 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.307979 | 0.511 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.021800 | 1.662 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.245226 | 0.610 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.030780 | 1.512 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.322259 | 0.492 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.150656 | 0.822 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.278746 | 0.555 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.310788 | 0.508 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.317024 | 0.499 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.030348 | 1.518 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.009805 | 2.009 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.238338 | 0.623 |
| R-HSA-169893 | Prolonged ERK activation events | 0.165936 | 0.780 |
| R-HSA-9839394 | TGFBR3 expression | 0.032675 | 1.486 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.158330 | 0.800 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.195683 | 0.708 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.245226 | 0.610 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.258816 | 0.587 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.170813 | 0.767 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.277650 | 0.557 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.103126 | 0.987 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.272163 | 0.565 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.304495 | 0.516 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.317024 | 0.499 |
| R-HSA-68886 | M Phase | 0.075255 | 1.123 |
| R-HSA-877300 | Interferon gamma signaling | 0.217311 | 0.663 |
| R-HSA-525793 | Myogenesis | 0.034615 | 1.461 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.265519 | 0.576 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.272163 | 0.565 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.310788 | 0.508 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.329330 | 0.482 |
| R-HSA-202403 | TCR signaling | 0.303361 | 0.518 |
| R-HSA-1640170 | Cell Cycle | 0.015717 | 1.804 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.087279 | 1.059 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.061507 | 1.211 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.069982 | 1.155 |
| R-HSA-448706 | Interleukin-1 processing | 0.103126 | 0.987 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.158330 | 0.800 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.158330 | 0.800 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.049367 | 1.307 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.298144 | 0.526 |
| R-HSA-73894 | DNA Repair | 0.263015 | 0.580 |
| R-HSA-373755 | Semaphorin interactions | 0.027329 | 1.563 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.173474 | 0.761 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.188346 | 0.725 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.008110 | 2.091 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.086808 | 1.061 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.086808 | 1.061 |
| R-HSA-390696 | Adrenoceptors | 0.094952 | 1.022 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.020403 | 1.690 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.202953 | 0.693 |
| R-HSA-71288 | Creatine metabolism | 0.202953 | 0.693 |
| R-HSA-109704 | PI3K Cascade | 0.097880 | 1.009 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.245226 | 0.610 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.258816 | 0.587 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.023708 | 1.625 |
| R-HSA-187687 | Signalling to ERKs | 0.317024 | 0.499 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.056154 | 1.251 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.023708 | 1.625 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.217299 | 0.663 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.074311 | 1.129 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.217299 | 0.663 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.245226 | 0.610 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.245226 | 0.610 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.180944 | 0.742 |
| R-HSA-392517 | Rap1 signalling | 0.195683 | 0.708 |
| R-HSA-8983711 | OAS antiviral response | 0.135097 | 0.869 |
| R-HSA-9834899 | Specification of the neural plate border | 0.195683 | 0.708 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.021250 | 1.673 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.258816 | 0.587 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.323205 | 0.491 |
| R-HSA-68875 | Mitotic Prophase | 0.123045 | 0.910 |
| R-HSA-112399 | IRS-mediated signalling | 0.118128 | 0.928 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.278746 | 0.555 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.245914 | 0.609 |
| R-HSA-622312 | Inflammasomes | 0.038625 | 1.413 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.323205 | 0.491 |
| R-HSA-74160 | Gene expression (Transcription) | 0.088579 | 1.053 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.224375 | 0.649 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.278746 | 0.555 |
| R-HSA-4839726 | Chromatin organization | 0.036716 | 1.435 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.142912 | 0.845 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.150656 | 0.822 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.158330 | 0.800 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.273294 | 0.563 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.127103 | 0.896 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.082508 | 1.084 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.025373 | 1.596 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.252051 | 0.599 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.250745 | 0.601 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.086808 | 1.061 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.158330 | 0.800 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.217299 | 0.663 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.130130 | 0.886 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.296692 | 0.528 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.319393 | 0.496 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.158062 | 0.801 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.326603 | 0.486 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.245226 | 0.610 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.145053 | 0.838 |
| R-HSA-9833110 | RSV-host interactions | 0.089394 | 1.049 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.158062 | 0.801 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.259907 | 0.585 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.259907 | 0.585 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.259907 | 0.585 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.111358 | 0.953 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.224375 | 0.649 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.323205 | 0.491 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.300028 | 0.523 |
| R-HSA-2559583 | Cellular Senescence | 0.270189 | 0.568 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.075973 | 1.119 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.303361 | 0.518 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.139309 | 0.856 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.303361 | 0.518 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.286673 | 0.543 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.096496 | 1.015 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.310788 | 0.508 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.139309 | 0.856 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.313342 | 0.504 |
| R-HSA-189200 | Cellular hexose transport | 0.224375 | 0.649 |
| R-HSA-212436 | Generic Transcription Pathway | 0.181176 | 0.742 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.195683 | 0.708 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.142400 | 0.846 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.180944 | 0.742 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.011350 | 1.945 |
| R-HSA-8853659 | RET signaling | 0.323205 | 0.491 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.329330 | 0.482 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.219668 | 0.658 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.139309 | 0.856 |
| R-HSA-983712 | Ion channel transport | 0.292259 | 0.534 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.013915 | 1.857 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.188346 | 0.725 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.236513 | 0.626 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.224375 | 0.649 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.297183 | 0.527 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.291737 | 0.535 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.263254 | 0.580 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.219668 | 0.658 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.054476 | 1.264 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.164895 | 0.783 |
| R-HSA-72172 | mRNA Splicing | 0.331748 | 0.479 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.335400 | 0.474 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.335400 | 0.474 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.339798 | 0.469 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.339798 | 0.469 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.341415 | 0.467 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.341415 | 0.467 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.341415 | 0.467 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.341415 | 0.467 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.341415 | 0.467 |
| R-HSA-201556 | Signaling by ALK | 0.341415 | 0.467 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.346366 | 0.460 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.347376 | 0.459 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.347376 | 0.459 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.347376 | 0.459 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.347376 | 0.459 |
| R-HSA-167169 | HIV Transcription Elongation | 0.347376 | 0.459 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.347376 | 0.459 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.347376 | 0.459 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.347376 | 0.459 |
| R-HSA-5260271 | Diseases of Immune System | 0.347376 | 0.459 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.347376 | 0.459 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.347376 | 0.459 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.349642 | 0.456 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.349642 | 0.456 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.353284 | 0.452 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.353284 | 0.452 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.353284 | 0.452 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.353284 | 0.452 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.356178 | 0.448 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.359139 | 0.445 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.359139 | 0.445 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.359139 | 0.445 |
| R-HSA-69206 | G1/S Transition | 0.362691 | 0.440 |
| R-HSA-1500931 | Cell-Cell communication | 0.363262 | 0.440 |
| R-HSA-165159 | MTOR signalling | 0.364941 | 0.438 |
| R-HSA-69481 | G2/M Checkpoints | 0.369180 | 0.433 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.370691 | 0.431 |
| R-HSA-9710421 | Defective pyroptosis | 0.370691 | 0.431 |
| R-HSA-8854214 | TBC/RABGAPs | 0.370691 | 0.431 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.372415 | 0.429 |
| R-HSA-2172127 | DAP12 interactions | 0.376389 | 0.424 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.376389 | 0.424 |
| R-HSA-69236 | G1 Phase | 0.376389 | 0.424 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.376389 | 0.424 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.376389 | 0.424 |
| R-HSA-5683826 | Surfactant metabolism | 0.376389 | 0.424 |
| R-HSA-373752 | Netrin-1 signaling | 0.376389 | 0.424 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.382035 | 0.418 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.382035 | 0.418 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.382035 | 0.418 |
| R-HSA-9843745 | Adipogenesis | 0.385286 | 0.414 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.387631 | 0.412 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.387631 | 0.412 |
| R-HSA-9675135 | Diseases of DNA repair | 0.387631 | 0.412 |
| R-HSA-75153 | Apoptotic execution phase | 0.387631 | 0.412 |
| R-HSA-9909396 | Circadian clock | 0.388487 | 0.411 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.393177 | 0.405 |
| R-HSA-437239 | Recycling pathway of L1 | 0.393177 | 0.405 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.398673 | 0.399 |
| R-HSA-73893 | DNA Damage Bypass | 0.404119 | 0.393 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.404119 | 0.393 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.404378 | 0.393 |
| R-HSA-422475 | Axon guidance | 0.407536 | 0.390 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.409517 | 0.388 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.414866 | 0.382 |
| R-HSA-1632852 | Macroautophagy | 0.420073 | 0.377 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.420166 | 0.377 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.420166 | 0.377 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.420166 | 0.377 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.420166 | 0.377 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.425419 | 0.371 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.425419 | 0.371 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.425419 | 0.371 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.426292 | 0.370 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.426292 | 0.370 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.426546 | 0.370 |
| R-HSA-418597 | G alpha (z) signalling events | 0.435784 | 0.361 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.435784 | 0.361 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.435784 | 0.361 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.438627 | 0.358 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.440897 | 0.356 |
| R-HSA-177929 | Signaling by EGFR | 0.440897 | 0.356 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.440897 | 0.356 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.440897 | 0.356 |
| R-HSA-69242 | S Phase | 0.444741 | 0.352 |
| R-HSA-166520 | Signaling by NTRKs | 0.444741 | 0.352 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.444741 | 0.352 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.445963 | 0.351 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.450984 | 0.346 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.450984 | 0.346 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.455960 | 0.341 |
| R-HSA-191859 | snRNP Assembly | 0.455960 | 0.341 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.455960 | 0.341 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.455960 | 0.341 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.457912 | 0.339 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.460890 | 0.336 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.460890 | 0.336 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.460890 | 0.336 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.460890 | 0.336 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.460890 | 0.336 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.460890 | 0.336 |
| R-HSA-379724 | tRNA Aminoacylation | 0.460890 | 0.336 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.462860 | 0.335 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.465777 | 0.332 |
| R-HSA-450294 | MAP kinase activation | 0.465777 | 0.332 |
| R-HSA-1989781 | PPARA activates gene expression | 0.465846 | 0.332 |
| R-HSA-9675108 | Nervous system development | 0.466975 | 0.331 |
| R-HSA-9612973 | Autophagy | 0.468823 | 0.329 |
| R-HSA-2262752 | Cellular responses to stress | 0.469596 | 0.328 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.470619 | 0.327 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.470619 | 0.327 |
| R-HSA-9707616 | Heme signaling | 0.470619 | 0.327 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.470619 | 0.327 |
| R-HSA-162587 | HIV Life Cycle | 0.471790 | 0.326 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.471790 | 0.326 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.475418 | 0.323 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.475418 | 0.323 |
| R-HSA-6799198 | Complex I biogenesis | 0.475418 | 0.323 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.484887 | 0.314 |
| R-HSA-109581 | Apoptosis | 0.486475 | 0.313 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.489557 | 0.310 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.492279 | 0.308 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.494186 | 0.306 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.494186 | 0.306 |
| R-HSA-167172 | Transcription of the HIV genome | 0.498773 | 0.302 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.498773 | 0.302 |
| R-HSA-913531 | Interferon Signaling | 0.499851 | 0.301 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.507822 | 0.294 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.507822 | 0.294 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.507822 | 0.294 |
| R-HSA-448424 | Interleukin-17 signaling | 0.507822 | 0.294 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.507822 | 0.294 |
| R-HSA-446728 | Cell junction organization | 0.508435 | 0.294 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.512286 | 0.290 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.515079 | 0.288 |
| R-HSA-8953854 | Metabolism of RNA | 0.516200 | 0.287 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.516710 | 0.287 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.516710 | 0.287 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.516710 | 0.287 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.520673 | 0.283 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.520673 | 0.283 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.521094 | 0.283 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.521094 | 0.283 |
| R-HSA-4086398 | Ca2+ pathway | 0.521094 | 0.283 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.525438 | 0.279 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.525438 | 0.279 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.525438 | 0.279 |
| R-HSA-380287 | Centrosome maturation | 0.529743 | 0.276 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.529743 | 0.276 |
| R-HSA-8852135 | Protein ubiquitination | 0.529743 | 0.276 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.529743 | 0.276 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.534010 | 0.272 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.542428 | 0.266 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.550694 | 0.259 |
| R-HSA-6806834 | Signaling by MET | 0.550694 | 0.259 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.550694 | 0.259 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.554772 | 0.256 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.558813 | 0.253 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.562817 | 0.250 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.566785 | 0.247 |
| R-HSA-199991 | Membrane Trafficking | 0.568395 | 0.245 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.570718 | 0.244 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.578477 | 0.238 |
| R-HSA-9609690 | HCMV Early Events | 0.581875 | 0.235 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.581875 | 0.235 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.582304 | 0.235 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.582304 | 0.235 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.586097 | 0.232 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.586097 | 0.232 |
| R-HSA-162582 | Signal Transduction | 0.587356 | 0.231 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.593580 | 0.227 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.599336 | 0.222 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.604553 | 0.219 |
| R-HSA-391251 | Protein folding | 0.604553 | 0.219 |
| R-HSA-5357801 | Programmed Cell Death | 0.606652 | 0.217 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.611704 | 0.213 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.615232 | 0.211 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.618191 | 0.209 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.622191 | 0.206 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.625624 | 0.204 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.625624 | 0.204 |
| R-HSA-190236 | Signaling by FGFR | 0.629026 | 0.201 |
| R-HSA-422356 | Regulation of insulin secretion | 0.629026 | 0.201 |
| R-HSA-3214847 | HATs acetylate histones | 0.632397 | 0.199 |
| R-HSA-68882 | Mitotic Anaphase | 0.632613 | 0.199 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.634906 | 0.197 |
| R-HSA-70171 | Glycolysis | 0.635738 | 0.197 |
| R-HSA-418990 | Adherens junctions interactions | 0.637188 | 0.196 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.639048 | 0.194 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.642329 | 0.192 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.642329 | 0.192 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.642329 | 0.192 |
| R-HSA-1483255 | PI Metabolism | 0.642329 | 0.192 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.648802 | 0.188 |
| R-HSA-162906 | HIV Infection | 0.657229 | 0.182 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.659401 | 0.181 |
| R-HSA-69239 | Synthesis of DNA | 0.661400 | 0.180 |
| R-HSA-211000 | Gene Silencing by RNA | 0.661400 | 0.180 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.667530 | 0.176 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.676519 | 0.170 |
| R-HSA-8939211 | ESR-mediated signaling | 0.678457 | 0.168 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.682377 | 0.166 |
| R-HSA-157118 | Signaling by NOTCH | 0.684615 | 0.165 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.684932 | 0.164 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.690967 | 0.161 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.690967 | 0.161 |
| R-HSA-373760 | L1CAM interactions | 0.693778 | 0.159 |
| R-HSA-70326 | Glucose metabolism | 0.696565 | 0.157 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.696565 | 0.157 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.696565 | 0.157 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.699326 | 0.155 |
| R-HSA-9609646 | HCMV Infection | 0.704451 | 0.152 |
| R-HSA-421270 | Cell-cell junction organization | 0.706377 | 0.151 |
| R-HSA-3371556 | Cellular response to heat stress | 0.707460 | 0.150 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.712762 | 0.147 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.712762 | 0.147 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.720535 | 0.142 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.720535 | 0.142 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.720535 | 0.142 |
| R-HSA-194138 | Signaling by VEGF | 0.720535 | 0.142 |
| R-HSA-114608 | Platelet degranulation | 0.725601 | 0.139 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.733029 | 0.135 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.742624 | 0.129 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.751876 | 0.124 |
| R-HSA-163685 | Integration of energy metabolism | 0.751876 | 0.124 |
| R-HSA-1280218 | Adaptive Immune System | 0.758046 | 0.120 |
| R-HSA-6807070 | PTEN Regulation | 0.758598 | 0.120 |
| R-HSA-9658195 | Leishmania infection | 0.759464 | 0.119 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.759464 | 0.119 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.767555 | 0.115 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.777696 | 0.109 |
| R-HSA-1483257 | Phospholipid metabolism | 0.781287 | 0.107 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.781287 | 0.107 |
| R-HSA-9758941 | Gastrulation | 0.781732 | 0.107 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.783723 | 0.106 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.783723 | 0.106 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.787650 | 0.104 |
| R-HSA-69306 | DNA Replication | 0.789587 | 0.103 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.793409 | 0.101 |
| R-HSA-9610379 | HCMV Late Events | 0.797162 | 0.098 |
| R-HSA-5619102 | SLC transporter disorders | 0.814933 | 0.089 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.815989 | 0.088 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.821600 | 0.085 |
| R-HSA-72306 | tRNA processing | 0.821600 | 0.085 |
| R-HSA-9824446 | Viral Infection Pathways | 0.824265 | 0.084 |
| R-HSA-1643685 | Disease | 0.828082 | 0.082 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.829600 | 0.081 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.829600 | 0.081 |
| R-HSA-611105 | Respiratory electron transport | 0.834228 | 0.079 |
| R-HSA-168255 | Influenza Infection | 0.835743 | 0.078 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.841665 | 0.075 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.842393 | 0.074 |
| R-HSA-69275 | G2/M Transition | 0.845968 | 0.073 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.848771 | 0.071 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.848771 | 0.071 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.850051 | 0.071 |
| R-HSA-5617833 | Cilium Assembly | 0.851524 | 0.070 |
| R-HSA-109582 | Hemostasis | 0.859250 | 0.066 |
| R-HSA-5663205 | Infectious disease | 0.861823 | 0.065 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.864365 | 0.063 |
| R-HSA-1266738 | Developmental Biology | 0.865724 | 0.063 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.867026 | 0.062 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.868243 | 0.061 |
| R-HSA-397014 | Muscle contraction | 0.879819 | 0.056 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.879819 | 0.056 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.880920 | 0.055 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.883515 | 0.054 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.889326 | 0.051 |
| R-HSA-9679506 | SARS-CoV Infections | 0.897138 | 0.047 |
| R-HSA-72312 | rRNA processing | 0.900027 | 0.046 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.912934 | 0.040 |
| R-HSA-168249 | Innate Immune System | 0.929229 | 0.032 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.936742 | 0.028 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.936969 | 0.028 |
| R-HSA-112316 | Neuronal System | 0.938238 | 0.028 |
| R-HSA-195721 | Signaling by WNT | 0.945635 | 0.024 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.956866 | 0.019 |
| R-HSA-1474244 | Extracellular matrix organization | 0.959948 | 0.018 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.963495 | 0.016 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.977896 | 0.010 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.978504 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 0.980416 | 0.009 |
| R-HSA-449147 | Signaling by Interleukins | 0.982001 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 0.982633 | 0.008 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.982970 | 0.007 |
| R-HSA-72766 | Translation | 0.984047 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.987485 | 0.005 |
| R-HSA-6798695 | Neutrophil degranulation | 0.987716 | 0.005 |
| R-HSA-168256 | Immune System | 0.993901 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.994712 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 0.995289 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.996440 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.997292 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.997376 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.999259 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999601 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.809 | 0.196 | 2 | 0.825 |
GRK1 |
0.806 | 0.268 | -2 | 0.694 |
MOS |
0.804 | 0.304 | 1 | 0.895 |
CLK3 |
0.800 | 0.123 | 1 | 0.865 |
CDC7 |
0.792 | 0.040 | 1 | 0.873 |
FAM20C |
0.788 | 0.133 | 2 | 0.717 |
PRPK |
0.788 | -0.009 | -1 | 0.376 |
IKKB |
0.785 | 0.001 | -2 | 0.627 |
BMPR1B |
0.784 | 0.120 | 1 | 0.818 |
PIM3 |
0.784 | 0.006 | -3 | 0.741 |
SKMLCK |
0.784 | 0.051 | -2 | 0.770 |
CDKL1 |
0.784 | 0.069 | -3 | 0.694 |
KIS |
0.783 | 0.085 | 1 | 0.732 |
ERK5 |
0.783 | 0.037 | 1 | 0.825 |
MTOR |
0.783 | -0.029 | 1 | 0.805 |
CAMK2G |
0.783 | 0.023 | 2 | 0.768 |
HIPK4 |
0.782 | 0.082 | 1 | 0.846 |
ATR |
0.782 | 0.034 | 1 | 0.860 |
CDKL5 |
0.781 | 0.094 | -3 | 0.684 |
GRK6 |
0.781 | 0.075 | 1 | 0.834 |
DSTYK |
0.781 | -0.025 | 2 | 0.855 |
GRK5 |
0.780 | -0.015 | -3 | 0.833 |
BMPR2 |
0.780 | -0.062 | -2 | 0.756 |
NLK |
0.780 | 0.013 | 1 | 0.854 |
GRK7 |
0.780 | 0.113 | 1 | 0.778 |
RIPK3 |
0.780 | 0.048 | 3 | 0.740 |
MLK1 |
0.779 | 0.028 | 2 | 0.766 |
RAF1 |
0.778 | -0.052 | 1 | 0.841 |
ICK |
0.777 | 0.105 | -3 | 0.737 |
CK1E |
0.777 | 0.173 | -3 | 0.707 |
SRPK1 |
0.776 | 0.022 | -3 | 0.643 |
IKKA |
0.776 | 0.009 | -2 | 0.633 |
NDR2 |
0.776 | -0.033 | -3 | 0.754 |
GRK4 |
0.776 | -0.010 | -2 | 0.719 |
PDHK4 |
0.775 | -0.181 | 1 | 0.852 |
TBK1 |
0.775 | -0.050 | 1 | 0.711 |
CAMK1B |
0.775 | -0.055 | -3 | 0.745 |
IKKE |
0.774 | -0.050 | 1 | 0.706 |
ACVR2B |
0.774 | 0.117 | -2 | 0.684 |
DYRK2 |
0.774 | 0.075 | 1 | 0.749 |
CHAK2 |
0.774 | -0.013 | -1 | 0.350 |
MLK3 |
0.773 | 0.042 | 2 | 0.706 |
CDK8 |
0.773 | 0.075 | 1 | 0.701 |
TGFBR1 |
0.773 | 0.051 | -2 | 0.674 |
GCN2 |
0.773 | -0.137 | 2 | 0.723 |
P38B |
0.772 | 0.133 | 1 | 0.672 |
CAMLCK |
0.772 | -0.019 | -2 | 0.747 |
ATM |
0.772 | 0.018 | 1 | 0.811 |
P38A |
0.771 | 0.117 | 1 | 0.746 |
JNK2 |
0.771 | 0.096 | 1 | 0.661 |
JNK3 |
0.770 | 0.084 | 1 | 0.695 |
CDK1 |
0.770 | 0.088 | 1 | 0.678 |
ACVR2A |
0.770 | 0.066 | -2 | 0.674 |
DAPK2 |
0.770 | -0.038 | -3 | 0.758 |
ALK2 |
0.770 | 0.062 | -2 | 0.680 |
RSK2 |
0.769 | -0.033 | -3 | 0.650 |
CDK19 |
0.769 | 0.086 | 1 | 0.663 |
WNK1 |
0.769 | -0.063 | -2 | 0.775 |
CLK2 |
0.769 | 0.076 | -3 | 0.631 |
TGFBR2 |
0.769 | -0.083 | -2 | 0.686 |
CDK7 |
0.768 | 0.055 | 1 | 0.721 |
BMPR1A |
0.768 | 0.088 | 1 | 0.800 |
DLK |
0.768 | 0.004 | 1 | 0.821 |
NEK6 |
0.768 | -0.107 | -2 | 0.739 |
CK1D |
0.767 | 0.156 | -3 | 0.670 |
PIM1 |
0.767 | -0.027 | -3 | 0.676 |
PRKD1 |
0.767 | -0.068 | -3 | 0.717 |
NIK |
0.766 | -0.120 | -3 | 0.773 |
PKN3 |
0.766 | -0.045 | -3 | 0.716 |
MLK2 |
0.766 | -0.023 | 2 | 0.751 |
DYRK4 |
0.766 | 0.094 | 1 | 0.675 |
ERK1 |
0.766 | 0.096 | 1 | 0.667 |
CDK18 |
0.766 | 0.076 | 1 | 0.654 |
ALK4 |
0.765 | -0.008 | -2 | 0.701 |
PDHK1 |
0.765 | -0.216 | 1 | 0.830 |
HIPK2 |
0.765 | 0.082 | 1 | 0.672 |
MLK4 |
0.765 | 0.023 | 2 | 0.676 |
CAMK2B |
0.765 | -0.006 | 2 | 0.772 |
LATS1 |
0.765 | 0.019 | -3 | 0.772 |
ULK2 |
0.764 | -0.194 | 2 | 0.711 |
NEK7 |
0.764 | -0.162 | -3 | 0.785 |
NDR1 |
0.764 | -0.076 | -3 | 0.724 |
MST4 |
0.764 | -0.054 | 2 | 0.803 |
CK1A2 |
0.764 | 0.160 | -3 | 0.663 |
P90RSK |
0.764 | -0.062 | -3 | 0.658 |
BCKDK |
0.763 | -0.129 | -1 | 0.299 |
TTBK2 |
0.763 | -0.078 | 2 | 0.640 |
RIPK1 |
0.763 | -0.087 | 1 | 0.820 |
PLK1 |
0.763 | -0.021 | -2 | 0.681 |
CK2A2 |
0.763 | 0.127 | 1 | 0.723 |
HUNK |
0.763 | -0.122 | 2 | 0.757 |
MASTL |
0.763 | -0.141 | -2 | 0.700 |
SRPK3 |
0.763 | 0.001 | -3 | 0.618 |
P38G |
0.762 | 0.077 | 1 | 0.593 |
AURC |
0.762 | -0.009 | -2 | 0.579 |
PKN2 |
0.762 | -0.055 | -3 | 0.722 |
DNAPK |
0.762 | 0.014 | 1 | 0.749 |
NUAK2 |
0.761 | -0.100 | -3 | 0.727 |
RSK4 |
0.761 | -0.001 | -3 | 0.633 |
HIPK1 |
0.761 | 0.051 | 1 | 0.764 |
CAMK2A |
0.761 | -0.022 | 2 | 0.781 |
GRK2 |
0.761 | 0.020 | -2 | 0.628 |
ANKRD3 |
0.760 | -0.087 | 1 | 0.848 |
P38D |
0.760 | 0.091 | 1 | 0.620 |
CDK5 |
0.759 | 0.050 | 1 | 0.740 |
TSSK2 |
0.759 | -0.076 | -5 | 0.817 |
PASK |
0.759 | 0.076 | -3 | 0.777 |
SMG1 |
0.759 | -0.043 | 1 | 0.817 |
CDK13 |
0.759 | 0.018 | 1 | 0.694 |
SRPK2 |
0.759 | -0.013 | -3 | 0.559 |
PAK1 |
0.759 | -0.033 | -2 | 0.714 |
CAMK2D |
0.759 | -0.100 | -3 | 0.721 |
MAK |
0.759 | 0.183 | -2 | 0.900 |
PKCD |
0.759 | -0.068 | 2 | 0.732 |
PLK3 |
0.759 | -0.034 | 2 | 0.746 |
P70S6KB |
0.758 | -0.060 | -3 | 0.666 |
PKR |
0.758 | -0.060 | 1 | 0.851 |
CLK4 |
0.758 | -0.008 | -3 | 0.648 |
PKACG |
0.758 | -0.060 | -2 | 0.631 |
RSK3 |
0.758 | -0.074 | -3 | 0.637 |
WNK3 |
0.758 | -0.186 | 1 | 0.818 |
TLK2 |
0.758 | -0.054 | 1 | 0.809 |
IRE1 |
0.758 | -0.090 | 1 | 0.812 |
MAPKAPK2 |
0.758 | -0.032 | -3 | 0.605 |
MARK4 |
0.757 | -0.114 | 4 | 0.742 |
CDK17 |
0.757 | 0.057 | 1 | 0.600 |
DYRK1A |
0.757 | 0.055 | 1 | 0.781 |
PRP4 |
0.756 | 0.034 | -3 | 0.734 |
MYLK4 |
0.756 | -0.014 | -2 | 0.667 |
PRKD2 |
0.756 | -0.081 | -3 | 0.640 |
LATS2 |
0.756 | -0.094 | -5 | 0.719 |
CK2A1 |
0.756 | 0.127 | 1 | 0.700 |
MSK1 |
0.756 | -0.018 | -3 | 0.629 |
MEK1 |
0.755 | -0.091 | 2 | 0.792 |
VRK2 |
0.755 | -0.122 | 1 | 0.870 |
MPSK1 |
0.755 | 0.080 | 1 | 0.811 |
MAPKAPK3 |
0.755 | -0.093 | -3 | 0.648 |
ULK1 |
0.755 | -0.185 | -3 | 0.750 |
NEK9 |
0.755 | -0.204 | 2 | 0.755 |
GRK3 |
0.755 | 0.039 | -2 | 0.593 |
YSK4 |
0.754 | -0.076 | 1 | 0.765 |
GSK3A |
0.754 | 0.046 | 4 | 0.419 |
DRAK1 |
0.754 | -0.009 | 1 | 0.775 |
ERK2 |
0.754 | 0.034 | 1 | 0.712 |
CDK12 |
0.754 | 0.021 | 1 | 0.665 |
PKACB |
0.754 | -0.011 | -2 | 0.578 |
AMPKA1 |
0.753 | -0.125 | -3 | 0.742 |
MSK2 |
0.753 | -0.064 | -3 | 0.635 |
CDK3 |
0.753 | 0.062 | 1 | 0.619 |
PKCA |
0.752 | -0.047 | 2 | 0.682 |
CLK1 |
0.752 | -0.020 | -3 | 0.608 |
JNK1 |
0.752 | 0.070 | 1 | 0.649 |
AURA |
0.751 | -0.008 | -2 | 0.561 |
PKCG |
0.751 | -0.057 | 2 | 0.702 |
MEKK3 |
0.751 | -0.010 | 1 | 0.790 |
PAK3 |
0.751 | -0.083 | -2 | 0.694 |
IRE2 |
0.751 | -0.087 | 2 | 0.671 |
DYRK1B |
0.751 | 0.039 | 1 | 0.692 |
AURB |
0.750 | -0.029 | -2 | 0.573 |
TSSK1 |
0.750 | -0.114 | -3 | 0.763 |
HIPK3 |
0.749 | 0.019 | 1 | 0.753 |
CDK14 |
0.749 | 0.041 | 1 | 0.690 |
CAMK4 |
0.749 | -0.125 | -3 | 0.699 |
GSK3B |
0.748 | 0.007 | 4 | 0.410 |
CDK16 |
0.748 | 0.064 | 1 | 0.618 |
CK1G1 |
0.748 | 0.055 | -3 | 0.694 |
PAK2 |
0.748 | -0.070 | -2 | 0.694 |
PRKX |
0.748 | -0.012 | -3 | 0.565 |
MNK2 |
0.747 | -0.088 | -2 | 0.684 |
DYRK3 |
0.747 | 0.024 | 1 | 0.766 |
PKCB |
0.747 | -0.075 | 2 | 0.693 |
PKG2 |
0.747 | -0.044 | -2 | 0.576 |
MNK1 |
0.746 | -0.081 | -2 | 0.687 |
GAK |
0.746 | 0.061 | 1 | 0.849 |
PLK2 |
0.745 | 0.014 | -3 | 0.722 |
PKCZ |
0.745 | -0.103 | 2 | 0.713 |
MEKK2 |
0.744 | -0.080 | 2 | 0.739 |
AMPKA2 |
0.744 | -0.125 | -3 | 0.700 |
AKT2 |
0.744 | -0.040 | -3 | 0.561 |
CDK2 |
0.744 | -0.023 | 1 | 0.747 |
MST3 |
0.744 | -0.026 | 2 | 0.792 |
CDK9 |
0.744 | -0.019 | 1 | 0.700 |
TLK1 |
0.744 | -0.087 | -2 | 0.712 |
MEK5 |
0.743 | -0.146 | 2 | 0.765 |
NIM1 |
0.743 | -0.182 | 3 | 0.731 |
CDK10 |
0.743 | 0.043 | 1 | 0.679 |
CHAK1 |
0.743 | -0.152 | 2 | 0.693 |
PIM2 |
0.743 | -0.053 | -3 | 0.615 |
PAK6 |
0.742 | -0.055 | -2 | 0.621 |
PERK |
0.742 | -0.162 | -2 | 0.715 |
PRKD3 |
0.742 | -0.100 | -3 | 0.607 |
NEK2 |
0.742 | -0.184 | 2 | 0.730 |
PLK4 |
0.742 | -0.103 | 2 | 0.564 |
MEKK1 |
0.742 | -0.137 | 1 | 0.791 |
SGK3 |
0.741 | -0.068 | -3 | 0.640 |
ERK7 |
0.740 | -0.002 | 2 | 0.494 |
NEK5 |
0.740 | -0.150 | 1 | 0.832 |
BRAF |
0.740 | -0.137 | -4 | 0.817 |
PKCH |
0.740 | -0.111 | 2 | 0.676 |
MOK |
0.740 | 0.098 | 1 | 0.783 |
TAO3 |
0.739 | -0.081 | 1 | 0.793 |
ZAK |
0.739 | -0.141 | 1 | 0.764 |
QSK |
0.739 | -0.119 | 4 | 0.717 |
TAK1 |
0.739 | 0.016 | 1 | 0.835 |
SMMLCK |
0.738 | -0.059 | -3 | 0.692 |
HRI |
0.738 | -0.190 | -2 | 0.732 |
WNK4 |
0.738 | -0.141 | -2 | 0.775 |
PHKG1 |
0.738 | -0.127 | -3 | 0.710 |
CAMK1G |
0.737 | -0.075 | -3 | 0.625 |
MARK3 |
0.737 | -0.093 | 4 | 0.674 |
IRAK4 |
0.737 | -0.142 | 1 | 0.809 |
MELK |
0.737 | -0.158 | -3 | 0.672 |
QIK |
0.736 | -0.184 | -3 | 0.718 |
DAPK3 |
0.736 | -0.026 | -3 | 0.680 |
BRSK1 |
0.735 | -0.116 | -3 | 0.661 |
TTBK1 |
0.735 | -0.120 | 2 | 0.568 |
NEK11 |
0.735 | -0.084 | 1 | 0.781 |
CHK1 |
0.735 | -0.156 | -3 | 0.700 |
SSTK |
0.734 | -0.078 | 4 | 0.701 |
NUAK1 |
0.734 | -0.153 | -3 | 0.655 |
GCK |
0.734 | -0.029 | 1 | 0.793 |
PKACA |
0.734 | -0.040 | -2 | 0.532 |
DAPK1 |
0.733 | -0.014 | -3 | 0.666 |
MARK2 |
0.733 | -0.119 | 4 | 0.645 |
ALPHAK3 |
0.733 | 0.094 | -1 | 0.366 |
EEF2K |
0.733 | -0.032 | 3 | 0.787 |
CAMKK1 |
0.733 | -0.163 | -2 | 0.616 |
PINK1 |
0.732 | -0.203 | 1 | 0.857 |
DCAMKL1 |
0.731 | -0.134 | -3 | 0.659 |
SNRK |
0.731 | -0.167 | 2 | 0.602 |
PDK1 |
0.730 | -0.098 | 1 | 0.799 |
MAPKAPK5 |
0.730 | -0.156 | -3 | 0.591 |
SIK |
0.730 | -0.143 | -3 | 0.629 |
MST2 |
0.730 | -0.072 | 1 | 0.790 |
LKB1 |
0.729 | -0.125 | -3 | 0.764 |
IRAK1 |
0.729 | -0.202 | -1 | 0.316 |
CK1A |
0.729 | 0.105 | -3 | 0.599 |
NEK8 |
0.729 | -0.165 | 2 | 0.744 |
MARK1 |
0.728 | -0.132 | 4 | 0.694 |
TAO2 |
0.728 | -0.131 | 2 | 0.775 |
CDK6 |
0.728 | 0.013 | 1 | 0.673 |
BRSK2 |
0.728 | -0.160 | -3 | 0.685 |
AKT1 |
0.727 | -0.060 | -3 | 0.578 |
VRK1 |
0.727 | -0.089 | 2 | 0.771 |
YANK3 |
0.727 | 0.014 | 2 | 0.396 |
CAMKK2 |
0.727 | -0.165 | -2 | 0.624 |
CDK4 |
0.726 | 0.016 | 1 | 0.655 |
HPK1 |
0.726 | -0.055 | 1 | 0.775 |
TNIK |
0.726 | -0.077 | 3 | 0.805 |
PKCT |
0.726 | -0.121 | 2 | 0.677 |
MAP3K15 |
0.725 | -0.099 | 1 | 0.756 |
MINK |
0.725 | -0.099 | 1 | 0.781 |
PAK4 |
0.724 | -0.056 | -2 | 0.589 |
DCAMKL2 |
0.724 | -0.129 | -3 | 0.671 |
PKCI |
0.724 | -0.118 | 2 | 0.694 |
PKCE |
0.724 | -0.072 | 2 | 0.686 |
P70S6K |
0.724 | -0.100 | -3 | 0.570 |
LRRK2 |
0.723 | -0.167 | 2 | 0.770 |
PAK5 |
0.723 | -0.077 | -2 | 0.577 |
HASPIN |
0.722 | -0.033 | -1 | 0.279 |
AKT3 |
0.722 | -0.036 | -3 | 0.506 |
CAMK1D |
0.721 | -0.097 | -3 | 0.546 |
HGK |
0.721 | -0.127 | 3 | 0.809 |
BUB1 |
0.721 | -0.035 | -5 | 0.781 |
PDHK3_TYR |
0.721 | 0.228 | 4 | 0.825 |
MEKK6 |
0.721 | -0.154 | 1 | 0.787 |
SGK1 |
0.720 | -0.048 | -3 | 0.487 |
NEK4 |
0.720 | -0.202 | 1 | 0.786 |
KHS1 |
0.719 | -0.068 | 1 | 0.770 |
TTK |
0.719 | -0.034 | -2 | 0.712 |
SLK |
0.719 | -0.109 | -2 | 0.612 |
ROCK2 |
0.719 | -0.060 | -3 | 0.669 |
STK33 |
0.718 | -0.128 | 2 | 0.583 |
MST1 |
0.718 | -0.113 | 1 | 0.774 |
PHKG2 |
0.718 | -0.140 | -3 | 0.656 |
KHS2 |
0.718 | -0.053 | 1 | 0.787 |
MRCKB |
0.717 | -0.062 | -3 | 0.599 |
BMPR2_TYR |
0.717 | 0.321 | -1 | 0.498 |
PDHK4_TYR |
0.717 | 0.233 | 2 | 0.832 |
NEK1 |
0.717 | -0.194 | 1 | 0.801 |
OSR1 |
0.716 | -0.043 | 2 | 0.743 |
EPHA6 |
0.716 | 0.267 | -1 | 0.481 |
LOK |
0.716 | -0.151 | -2 | 0.646 |
PDHK1_TYR |
0.715 | 0.256 | -1 | 0.442 |
DMPK1 |
0.715 | -0.029 | -3 | 0.624 |
TXK |
0.713 | 0.208 | 1 | 0.822 |
MAP2K6_TYR |
0.713 | 0.177 | -1 | 0.406 |
FYN |
0.713 | 0.291 | -1 | 0.556 |
PBK |
0.712 | -0.079 | 1 | 0.768 |
CHK2 |
0.710 | -0.098 | -3 | 0.496 |
PKN1 |
0.710 | -0.108 | -3 | 0.585 |
MRCKA |
0.710 | -0.087 | -3 | 0.619 |
PTK2 |
0.710 | 0.317 | -1 | 0.596 |
BLK |
0.710 | 0.232 | -1 | 0.507 |
MEK2 |
0.709 | -0.253 | 2 | 0.738 |
RIPK2 |
0.709 | -0.202 | 1 | 0.721 |
YSK1 |
0.709 | -0.156 | 2 | 0.736 |
EPHB4 |
0.709 | 0.154 | -1 | 0.408 |
MAP2K4_TYR |
0.709 | 0.054 | -1 | 0.379 |
LCK |
0.708 | 0.238 | -1 | 0.514 |
SBK |
0.708 | -0.068 | -3 | 0.433 |
TESK1_TYR |
0.705 | 0.017 | 3 | 0.833 |
EPHA4 |
0.705 | 0.152 | 2 | 0.762 |
ASK1 |
0.705 | -0.114 | 1 | 0.742 |
CAMK1A |
0.705 | -0.098 | -3 | 0.509 |
CRIK |
0.704 | -0.055 | -3 | 0.583 |
CK1G2 |
0.704 | 0.124 | -3 | 0.629 |
HCK |
0.703 | 0.167 | -1 | 0.482 |
BIKE |
0.702 | -0.048 | 1 | 0.724 |
MAP2K7_TYR |
0.702 | -0.036 | 2 | 0.795 |
SYK |
0.702 | 0.277 | -1 | 0.549 |
SRMS |
0.701 | 0.098 | 1 | 0.836 |
BMX |
0.701 | 0.103 | -1 | 0.397 |
ROCK1 |
0.701 | -0.077 | -3 | 0.617 |
MYO3B |
0.701 | -0.123 | 2 | 0.743 |
PKMYT1_TYR |
0.700 | -0.069 | 3 | 0.818 |
CK1G3 |
0.700 | 0.057 | -3 | 0.556 |
YES1 |
0.700 | 0.041 | -1 | 0.412 |
ABL2 |
0.700 | 0.030 | -1 | 0.361 |
PINK1_TYR |
0.699 | -0.037 | 1 | 0.848 |
ITK |
0.698 | 0.107 | -1 | 0.423 |
PKG1 |
0.698 | -0.099 | -2 | 0.496 |
MYO3A |
0.698 | -0.122 | 1 | 0.777 |
EPHB3 |
0.697 | 0.109 | -1 | 0.406 |
CSF1R |
0.697 | 0.030 | 3 | 0.767 |
EPHB2 |
0.697 | 0.115 | -1 | 0.419 |
FER |
0.696 | 0.007 | 1 | 0.860 |
YANK2 |
0.696 | 0.000 | 2 | 0.420 |
FGR |
0.695 | 0.016 | 1 | 0.832 |
LIMK2_TYR |
0.695 | -0.068 | -3 | 0.790 |
NEK3 |
0.695 | -0.255 | 1 | 0.750 |
INSRR |
0.695 | 0.060 | 3 | 0.724 |
EPHB1 |
0.694 | 0.087 | 1 | 0.823 |
KIT |
0.694 | 0.047 | 3 | 0.769 |
JAK3 |
0.694 | 0.095 | 1 | 0.782 |
MET |
0.694 | 0.108 | 3 | 0.755 |
EPHA7 |
0.694 | 0.126 | 2 | 0.747 |
RET |
0.694 | -0.050 | 1 | 0.799 |
MST1R |
0.693 | -0.017 | 3 | 0.782 |
LYN |
0.693 | 0.121 | 3 | 0.697 |
ABL1 |
0.693 | -0.017 | -1 | 0.349 |
FLT1 |
0.693 | 0.133 | -1 | 0.461 |
TAO1 |
0.692 | -0.160 | 1 | 0.714 |
EPHA8 |
0.691 | 0.161 | -1 | 0.479 |
TNK2 |
0.690 | -0.018 | 3 | 0.741 |
SRC |
0.690 | 0.111 | -1 | 0.480 |
STLK3 |
0.690 | -0.139 | 1 | 0.729 |
TYRO3 |
0.690 | -0.095 | 3 | 0.752 |
MERTK |
0.689 | -0.019 | 3 | 0.739 |
FGFR2 |
0.689 | -0.001 | 3 | 0.773 |
JAK2 |
0.689 | -0.050 | 1 | 0.787 |
TEC |
0.688 | -0.028 | -1 | 0.336 |
EPHA5 |
0.688 | 0.098 | 2 | 0.749 |
DDR1 |
0.687 | -0.099 | 4 | 0.753 |
ROS1 |
0.687 | -0.081 | 3 | 0.730 |
FRK |
0.687 | 0.093 | -1 | 0.462 |
KDR |
0.687 | 0.031 | 3 | 0.736 |
EPHA3 |
0.687 | 0.049 | 2 | 0.718 |
TYK2 |
0.686 | -0.136 | 1 | 0.791 |
AAK1 |
0.685 | -0.032 | 1 | 0.626 |
EPHA2 |
0.684 | 0.155 | -1 | 0.463 |
LIMK1_TYR |
0.684 | -0.201 | 2 | 0.771 |
BTK |
0.683 | -0.070 | -1 | 0.362 |
FGFR3 |
0.682 | 0.023 | 3 | 0.753 |
TEK |
0.682 | -0.030 | 3 | 0.701 |
EPHA1 |
0.681 | 0.025 | 3 | 0.735 |
ERBB2 |
0.680 | 0.015 | 1 | 0.745 |
AXL |
0.680 | -0.098 | 3 | 0.750 |
EGFR |
0.680 | 0.033 | 1 | 0.645 |
WEE1_TYR |
0.680 | -0.068 | -1 | 0.320 |
FGFR4 |
0.680 | 0.011 | -1 | 0.359 |
ERBB4 |
0.680 | 0.136 | 1 | 0.656 |
ZAP70 |
0.680 | 0.140 | -1 | 0.474 |
MATK |
0.679 | -0.047 | -1 | 0.319 |
FLT3 |
0.678 | -0.078 | 3 | 0.752 |
PTK2B |
0.678 | -0.031 | -1 | 0.342 |
CSK |
0.677 | -0.010 | 2 | 0.733 |
JAK1 |
0.676 | -0.077 | 1 | 0.727 |
PTK6 |
0.675 | -0.151 | -1 | 0.312 |
DDR2 |
0.675 | -0.015 | 3 | 0.728 |
NTRK3 |
0.675 | -0.061 | -1 | 0.331 |
NTRK1 |
0.674 | -0.101 | -1 | 0.351 |
PDGFRB |
0.674 | -0.157 | 3 | 0.767 |
FGFR1 |
0.674 | -0.105 | 3 | 0.739 |
ALK |
0.673 | -0.106 | 3 | 0.693 |
TNK1 |
0.673 | -0.150 | 3 | 0.733 |
NEK10_TYR |
0.672 | -0.133 | 1 | 0.696 |
LTK |
0.672 | -0.112 | 3 | 0.716 |
INSR |
0.672 | -0.062 | 3 | 0.706 |
FLT4 |
0.672 | -0.056 | 3 | 0.730 |
IGF1R |
0.667 | -0.007 | 3 | 0.648 |
TNNI3K_TYR |
0.667 | -0.154 | 1 | 0.787 |
PDGFRA |
0.666 | -0.182 | 3 | 0.757 |
NTRK2 |
0.664 | -0.161 | 3 | 0.733 |
FES |
0.660 | -0.029 | -1 | 0.360 |
MUSK |
0.647 | -0.121 | 1 | 0.636 |