Motif 401 (n=89)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S561 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A6NI28 | ARHGAP42 | S600 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| E9PAV3 | NACA | S193 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00192 | ARVCF | S343 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00764 | PDXK | S285 | ochoa | Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) | Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503, PubMed:9099727). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions. {ECO:0000269|PubMed:10987144, ECO:0000269|PubMed:17766369, ECO:0000269|PubMed:19351586, ECO:0000269|PubMed:31187503, ECO:0000269|PubMed:9099727, ECO:0000305}. |
| O14497 | ARID1A | S1609 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14598 | VCY | S27 | ochoa | Testis-specific basic protein Y 1 (Basic charge, Y-linked 1) (Variably charged protein Y) | May mediate a process in spermatogenesis or may play a role in sex ratio distortion. |
| O15381 | NVL | S180 | ochoa | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. |
| O15534 | PER1 | S592 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43623 | SNAI2 | S87 | psp | Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) | Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. {ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}. |
| O60239 | SH3BP5 | S351 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
| O60496 | DOK2 | S282 | ochoa | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
| O75509 | TNFRSF21 | S541 | ochoa | Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358) | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (PubMed:34012073). {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:22761420, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:9714541}. |
| O95696 | BRD1 | S814 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95754 | SEMA4F | S751 | ochoa | Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W) | Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity). {ECO:0000250|UniProtKB:Q9Z123, ECO:0000250|UniProtKB:Q9Z143}. |
| P02724 | GYPA | S130 | ochoa | Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:15331714}.; FUNCTION: (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. {ECO:0000269|PubMed:8009226}. |
| P19438 | TNFRSF1A | S350 | ochoa | Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| P21333 | FLNA | S481 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2279 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21860 | ERBB3 | S1051 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P22570 | FDXR | S317 | ochoa | NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase) (EC 1.18.1.-) | Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (By similarity). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:38425362). {ECO:0000250|UniProtKB:P08165, ECO:0000269|PubMed:38425362}. |
| P27816 | MAP4 | S764 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30414 | NKTR | S325 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P41250 | GARS1 | S704 | psp | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P48634 | PRRC2A | S305 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P51858 | HDGF | S165 | ochoa | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| P52179 | MYOM1 | S618 | psp | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P57073 | SOX8 | S344 | ochoa | Transcription factor SOX-8 | Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). {ECO:0000250|UniProtKB:Q04886}. |
| P78344 | EIF4G2 | S500 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| Q01581 | HMGCS1 | S495 | ochoa | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| Q08495 | DMTN | S96 | ochoa|psp | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q09666 | AHNAK | S1747 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3509 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4425 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4903 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4995 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5186 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5214 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5310 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5321 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12815 | TROAP | S213 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12888 | TP53BP1 | S452 | psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S630 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13459 | MYO9B | S1122 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13507 | TRPC3 | S785 | psp | Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:29726814, PubMed:30139744, PubMed:35051376, PubMed:9417057, PubMed:9930701, PubMed:10611319). {ECO:0000269|PubMed:10611319, ECO:0000269|PubMed:29726814, ECO:0000269|PubMed:30139744, ECO:0000269|PubMed:35051376, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.; FUNCTION: [Isoform 2]: Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. {ECO:0000269|PubMed:8646775}. |
| Q14203 | DCTN1 | S212 | psp | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14315 | FLNC | S1156 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q2LD37 | BLTP1 | S4613 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2TAZ0 | ATG2A | S1327 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q5VST9 | OBSCN | S4628 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT52 | RPRD2 | S1092 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5XKK7 | FAM219B | S35 | ochoa | Protein FAM219B | None |
| Q6NV74 | CRACDL | S356 | ochoa | CRACD-like protein | None |
| Q6P4R8 | NFRKB | S900 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6P6C2 | ALKBH5 | S305 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q6ZMQ8 | AATK | S520 | ochoa | Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) | May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}. |
| Q70E73 | RAPH1 | S853 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q7Z2K8 | GPRIN1 | S95 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q8IVF2 | AHNAK2 | S729 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1712 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2207 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2702 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4187 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4785 | ochoa | Protein AHNAK2 | None |
| Q8N3V7 | SYNPO | S235 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N4C8 | MINK1 | S927 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NC74 | RBBP8NL | S151 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8NDF8 | TENT4B | S477 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8NEN9 | PDZD8 | S967 | ochoa | PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) | Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}. |
| Q8TBP0 | TBC1D16 | S126 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TD16 | BICD2 | S329 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8WY36 | BBX | S183 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q96C92 | ENTR1 | S88 | ochoa | Endosome-associated-trafficking regulator 1 (Antigen NY-CO-3) (Serologically defined colon cancer antigen 3) | Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:A2AIW0, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}. |
| Q96M11 | HYLS1 | S79 | ochoa | Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1) | Plays a role in ciliogenesis. {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}. |
| Q96PE2 | ARHGEF17 | S1002 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q9BR77 | CCDC77 | S44 | ochoa | Coiled-coil domain-containing protein 77 | None |
| Q9C0C9 | UBE2O | S1231 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9HCM3 | KIAA1549 | S1395 | ochoa | UPF0606 protein KIAA1549 | May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}. |
| Q9HCM3 | KIAA1549 | S1503 | ochoa | UPF0606 protein KIAA1549 | May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}. |
| Q9HCX4 | TRPC7 | S714 | psp | Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250|UniProtKB:Q9WVC5}. |
| Q9NQZ2 | UTP3 | S37 | ochoa | Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) | Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}. |
| Q9ULC8 | ZDHHC8 | S675 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9UPA5 | BSN | S1411 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UPQ9 | TNRC6B | S879 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UQ35 | SRRM2 | S1300 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y446 | PKP3 | S323 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y6Q9 | NCOA3 | S967 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| P28066 | PSMA5 | S159 | Sugiyama | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P51452 | DUSP3 | S43 | Sugiyama | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439). {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000032 | 4.497 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.000236 | 3.627 |
| R-HSA-3295583 | TRP channels | 0.000759 | 3.120 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.000759 | 3.120 |
| R-HSA-1989781 | PPARA activates gene expression | 0.002680 | 2.572 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.002815 | 2.551 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.001905 | 2.720 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.002374 | 2.624 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.003571 | 2.447 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.004982 | 2.303 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.006043 | 2.219 |
| R-HSA-446728 | Cell junction organization | 0.005982 | 2.223 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.006609 | 2.180 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.032263 | 1.491 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.032263 | 1.491 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.042787 | 1.369 |
| R-HSA-5579026 | Defective CYP11A1 causes AICSR | 0.048007 | 1.319 |
| R-HSA-2395516 | Electron transport from NADPH to Ferredoxin | 0.053198 | 1.274 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.058361 | 1.234 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.073685 | 1.133 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.078738 | 1.104 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.083763 | 1.077 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.093733 | 1.028 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.098678 | 1.006 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.098678 | 1.006 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.108488 | 0.965 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.127791 | 0.893 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.127791 | 0.893 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.146682 | 0.834 |
| R-HSA-429947 | Deadenylation of mRNA | 0.151341 | 0.820 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.165167 | 0.782 |
| R-HSA-72649 | Translation initiation complex formation | 0.287854 | 0.541 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.295626 | 0.529 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.310918 | 0.507 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.303313 | 0.518 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.083763 | 1.077 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.023452 | 1.630 |
| R-HSA-6798695 | Neutrophil degranulation | 0.265350 | 0.576 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.037539 | 1.426 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.093733 | 1.028 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.178771 | 0.748 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.093733 | 1.028 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.098678 | 1.006 |
| R-HSA-3371568 | Attenuation phase | 0.226804 | 0.644 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.160583 | 0.794 |
| R-HSA-9907900 | Proteasome assembly | 0.247708 | 0.606 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.029822 | 1.525 |
| R-HSA-75893 | TNF signaling | 0.295626 | 0.529 |
| R-HSA-202670 | ERKs are inactivated | 0.078738 | 1.104 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.083763 | 1.077 |
| R-HSA-964975 | Vitamin B6 activation to pyridoxal phosphate | 0.108488 | 0.965 |
| R-HSA-9839394 | TGFBR3 expression | 0.155975 | 0.807 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.183257 | 0.737 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.255912 | 0.592 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.276038 | 0.559 |
| R-HSA-6807070 | PTEN Regulation | 0.054399 | 1.264 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.310918 | 0.507 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.174261 | 0.759 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.151341 | 0.820 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.255912 | 0.592 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.046954 | 1.328 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.178771 | 0.748 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.155975 | 0.807 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.155975 | 0.807 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.307126 | 0.513 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.127791 | 0.893 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.127791 | 0.893 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.132552 | 0.878 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.187719 | 0.726 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.205325 | 0.688 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.205325 | 0.688 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.235233 | 0.629 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.259981 | 0.585 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.279998 | 0.553 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.283937 | 0.547 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.094488 | 1.025 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.264028 | 0.578 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.113353 | 0.946 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.192156 | 0.716 |
| R-HSA-4641258 | Degradation of DVL | 0.213986 | 0.670 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.222554 | 0.653 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.231030 | 0.636 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.280434 | 0.552 |
| R-HSA-5689603 | UCH proteinases | 0.077637 | 1.110 |
| R-HSA-73887 | Death Receptor Signaling | 0.068608 | 1.164 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.209668 | 0.678 |
| R-HSA-4641257 | Degradation of AXIN | 0.213986 | 0.670 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.213986 | 0.670 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.279998 | 0.553 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.287854 | 0.541 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.203958 | 0.690 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.136884 | 0.864 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.307126 | 0.513 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.178771 | 0.748 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.192156 | 0.716 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.132552 | 0.878 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.192156 | 0.716 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.196570 | 0.706 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.196570 | 0.706 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.200959 | 0.697 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.200959 | 0.697 |
| R-HSA-169911 | Regulation of Apoptosis | 0.205325 | 0.688 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.235233 | 0.629 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.235233 | 0.629 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.272056 | 0.565 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.279998 | 0.553 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.303313 | 0.518 |
| R-HSA-9909396 | Circadian clock | 0.009026 | 2.044 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.113353 | 0.946 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.251821 | 0.599 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.255912 | 0.592 |
| R-HSA-69275 | G2/M Transition | 0.308670 | 0.511 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.226804 | 0.644 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.231030 | 0.636 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.231030 | 0.636 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.283937 | 0.547 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.194050 | 0.712 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.205325 | 0.688 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.231030 | 0.636 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.291751 | 0.535 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.014684 | 1.833 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.238009 | 0.623 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.068605 | 1.164 |
| R-HSA-198753 | ERK/MAPK targets | 0.132552 | 0.878 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.048289 | 1.316 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.174261 | 0.759 |
| R-HSA-3371511 | HSF1 activation | 0.209668 | 0.678 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.222554 | 0.653 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.243572 | 0.613 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.247708 | 0.606 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.251821 | 0.599 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.247708 | 0.606 |
| R-HSA-9930044 | Nuclear RNA decay | 0.192156 | 0.716 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.295626 | 0.529 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.310918 | 0.507 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.015979 | 1.796 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.141997 | 0.848 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.024381 | 1.613 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.251821 | 0.599 |
| R-HSA-69481 | G2/M Checkpoints | 0.182251 | 0.739 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.192156 | 0.716 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.071394 | 1.146 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.063497 | 1.197 |
| R-HSA-8963896 | HDL assembly | 0.093733 | 1.028 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.020508 | 1.688 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.196570 | 0.706 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.226804 | 0.644 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.231030 | 0.636 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.251821 | 0.599 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.069860 | 1.156 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.152019 | 0.818 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.030613 | 1.514 |
| R-HSA-9766229 | Degradation of CDH1 | 0.268053 | 0.572 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.276038 | 0.559 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.021371 | 1.670 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.021371 | 1.670 |
| R-HSA-418990 | Adherens junctions interactions | 0.041894 | 1.378 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.088953 | 1.051 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.251821 | 0.599 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.251821 | 0.599 |
| R-HSA-421270 | Cell-cell junction organization | 0.061685 | 1.210 |
| R-HSA-9694548 | Maturation of spike protein | 0.231030 | 0.636 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.276038 | 0.559 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.122182 | 0.913 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.083763 | 1.077 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 0.151341 | 0.820 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.283937 | 0.547 |
| R-HSA-1500931 | Cell-Cell communication | 0.010442 | 1.981 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.039266 | 1.406 |
| R-HSA-210993 | Tie2 Signaling | 0.118192 | 0.927 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.068338 | 1.165 |
| R-HSA-8854214 | TBC/RABGAPs | 0.243572 | 0.613 |
| R-HSA-437239 | Recycling pathway of L1 | 0.259981 | 0.585 |
| R-HSA-8983711 | OAS antiviral response | 0.083763 | 1.077 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.080820 | 1.092 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.080820 | 1.092 |
| R-HSA-69541 | Stabilization of p53 | 0.222554 | 0.653 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.276038 | 0.559 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.141792 | 0.848 |
| R-HSA-73942 | DNA Damage Reversal | 0.098678 | 1.006 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.174261 | 0.759 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.076060 | 1.119 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.299480 | 0.524 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.233982 | 0.631 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.072939 | 1.137 |
| R-HSA-351202 | Metabolism of polyamines | 0.310918 | 0.507 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.203958 | 0.690 |
| R-HSA-1266738 | Developmental Biology | 0.275707 | 0.560 |
| R-HSA-2559583 | Cellular Senescence | 0.095942 | 1.018 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.151341 | 0.820 |
| R-HSA-9824272 | Somitogenesis | 0.251821 | 0.599 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.058007 | 1.237 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.226804 | 0.644 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.239414 | 0.621 |
| R-HSA-379724 | tRNA Aminoacylation | 0.310918 | 0.507 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.310918 | 0.507 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.268053 | 0.572 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.268053 | 0.572 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.279998 | 0.553 |
| R-HSA-8853659 | RET signaling | 0.209668 | 0.678 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.082427 | 1.084 |
| R-HSA-2262752 | Cellular responses to stress | 0.114188 | 0.942 |
| R-HSA-165159 | MTOR signalling | 0.239414 | 0.621 |
| R-HSA-418346 | Platelet homeostasis | 0.136434 | 0.865 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.028422 | 1.546 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.186244 | 0.730 |
| R-HSA-373752 | Netrin-1 signaling | 0.033236 | 1.478 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.068608 | 1.164 |
| R-HSA-422475 | Axon guidance | 0.035578 | 1.449 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.217412 | 0.663 |
| R-HSA-9675108 | Nervous system development | 0.047270 | 1.325 |
| R-HSA-8957322 | Metabolism of steroids | 0.290493 | 0.537 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.010784 | 1.967 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.121820 | 0.914 |
| R-HSA-983712 | Ion channel transport | 0.105910 | 0.975 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.312690 | 0.505 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.314689 | 0.502 |
| R-HSA-211976 | Endogenous sterols | 0.314689 | 0.502 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.314689 | 0.502 |
| R-HSA-450294 | MAP kinase activation | 0.314689 | 0.502 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.318440 | 0.497 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.318440 | 0.497 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.322171 | 0.492 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.322171 | 0.492 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.322171 | 0.492 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.322171 | 0.492 |
| R-HSA-8848021 | Signaling by PTK6 | 0.322171 | 0.492 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.322171 | 0.492 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.329572 | 0.482 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.329572 | 0.482 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.333242 | 0.477 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.336605 | 0.473 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.336698 | 0.473 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.336698 | 0.473 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.336893 | 0.473 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.336893 | 0.473 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.340524 | 0.468 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.340524 | 0.468 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.340524 | 0.468 |
| R-HSA-73894 | DNA Repair | 0.344292 | 0.463 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.347727 | 0.459 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.347727 | 0.459 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.347727 | 0.459 |
| R-HSA-448424 | Interleukin-17 signaling | 0.347727 | 0.459 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.351299 | 0.454 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.351299 | 0.454 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.351299 | 0.454 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.354852 | 0.450 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.354852 | 0.450 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.358385 | 0.446 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.358385 | 0.446 |
| R-HSA-4086398 | Ca2+ pathway | 0.358385 | 0.446 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.361900 | 0.441 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.361900 | 0.441 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.361900 | 0.441 |
| R-HSA-380287 | Centrosome maturation | 0.365395 | 0.437 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.372330 | 0.429 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.372330 | 0.429 |
| R-HSA-5619084 | ABC transporter disorders | 0.375769 | 0.425 |
| R-HSA-4086400 | PCP/CE pathway | 0.375769 | 0.425 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.375769 | 0.425 |
| R-HSA-9659379 | Sensory processing of sound | 0.379189 | 0.421 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.379189 | 0.421 |
| R-HSA-913531 | Interferon Signaling | 0.380072 | 0.420 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.385974 | 0.413 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.390965 | 0.408 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.396015 | 0.402 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.396015 | 0.402 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.396015 | 0.402 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.399325 | 0.399 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.402618 | 0.395 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.405106 | 0.392 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.405893 | 0.392 |
| R-HSA-8939211 | ESR-mediated signaling | 0.410826 | 0.386 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.410826 | 0.386 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.412389 | 0.385 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.415611 | 0.381 |
| R-HSA-157118 | Signaling by NOTCH | 0.416519 | 0.380 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.418816 | 0.378 |
| R-HSA-202424 | Downstream TCR signaling | 0.418816 | 0.378 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.422003 | 0.375 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.425172 | 0.371 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.428325 | 0.368 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.428325 | 0.368 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.431460 | 0.365 |
| R-HSA-4839726 | Chromatin organization | 0.433433 | 0.363 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.434579 | 0.362 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.440765 | 0.356 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.443833 | 0.353 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.443833 | 0.353 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.443833 | 0.353 |
| R-HSA-5688426 | Deubiquitination | 0.444567 | 0.352 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.446411 | 0.350 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.446885 | 0.350 |
| R-HSA-72766 | Translation | 0.447350 | 0.349 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.449919 | 0.347 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.449919 | 0.347 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.449919 | 0.347 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.450089 | 0.347 |
| R-HSA-109582 | Hemostasis | 0.450607 | 0.346 |
| R-HSA-3214847 | HATs acetylate histones | 0.452938 | 0.344 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.455940 | 0.341 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.455940 | 0.341 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.458925 | 0.338 |
| R-HSA-416476 | G alpha (q) signalling events | 0.461042 | 0.336 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.461895 | 0.335 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.461895 | 0.335 |
| R-HSA-382551 | Transport of small molecules | 0.469531 | 0.328 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.470707 | 0.327 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.470707 | 0.327 |
| R-HSA-449147 | Signaling by Interleukins | 0.472213 | 0.326 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.473613 | 0.325 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.473613 | 0.325 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.479377 | 0.319 |
| R-HSA-69239 | Synthesis of DNA | 0.479377 | 0.319 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.479377 | 0.319 |
| R-HSA-211000 | Gene Silencing by RNA | 0.479377 | 0.319 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.482235 | 0.317 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.482235 | 0.317 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.482235 | 0.317 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.482235 | 0.317 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.485078 | 0.314 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.485078 | 0.314 |
| R-HSA-202403 | TCR signaling | 0.487906 | 0.312 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.487906 | 0.312 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.487906 | 0.312 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.493137 | 0.307 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.493515 | 0.307 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.493515 | 0.307 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.496297 | 0.304 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.496297 | 0.304 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.499063 | 0.302 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.504552 | 0.297 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.504552 | 0.297 |
| R-HSA-8953854 | Metabolism of RNA | 0.504731 | 0.297 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.505297 | 0.296 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.509980 | 0.292 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.509980 | 0.292 |
| R-HSA-373760 | L1CAM interactions | 0.509980 | 0.292 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.512673 | 0.290 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.515350 | 0.288 |
| R-HSA-5693538 | Homology Directed Repair | 0.515350 | 0.288 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.517269 | 0.286 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.518014 | 0.286 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.518014 | 0.286 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.518014 | 0.286 |
| R-HSA-195721 | Signaling by WNT | 0.520655 | 0.283 |
| R-HSA-3371556 | Cellular response to heat stress | 0.523297 | 0.281 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.523297 | 0.281 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.525916 | 0.279 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.525916 | 0.279 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.528522 | 0.277 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.528522 | 0.277 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.528522 | 0.277 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.531114 | 0.275 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.531114 | 0.275 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.536255 | 0.271 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.536255 | 0.271 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.536255 | 0.271 |
| R-HSA-69206 | G1/S Transition | 0.536255 | 0.271 |
| R-HSA-114608 | Platelet degranulation | 0.541340 | 0.267 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.543862 | 0.265 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.548865 | 0.261 |
| R-HSA-9843745 | Adipogenesis | 0.553813 | 0.257 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.558708 | 0.253 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.561649 | 0.251 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.573076 | 0.242 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.573076 | 0.242 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.577762 | 0.238 |
| R-HSA-9664407 | Parasite infection | 0.577762 | 0.238 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.577762 | 0.238 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.580086 | 0.237 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.589256 | 0.230 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.593766 | 0.226 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.596003 | 0.225 |
| R-HSA-69242 | S Phase | 0.598227 | 0.223 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.598227 | 0.223 |
| R-HSA-166520 | Signaling by NTRKs | 0.598227 | 0.223 |
| R-HSA-9758941 | Gastrulation | 0.600440 | 0.222 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.602073 | 0.220 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.604828 | 0.218 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.607005 | 0.217 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.609170 | 0.215 |
| R-HSA-69306 | DNA Replication | 0.609170 | 0.215 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.611322 | 0.214 |
| R-HSA-162582 | Signal Transduction | 0.614147 | 0.212 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.619817 | 0.208 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.621983 | 0.206 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.623996 | 0.205 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.623996 | 0.205 |
| R-HSA-109581 | Apoptosis | 0.628128 | 0.202 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.632216 | 0.199 |
| R-HSA-388396 | GPCR downstream signalling | 0.636846 | 0.196 |
| R-HSA-212436 | Generic Transcription Pathway | 0.637256 | 0.196 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.638265 | 0.195 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.646178 | 0.190 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.648129 | 0.188 |
| R-HSA-68886 | M Phase | 0.649703 | 0.187 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.651046 | 0.186 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.651999 | 0.186 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.653919 | 0.184 |
| R-HSA-74160 | Gene expression (Transcription) | 0.659639 | 0.181 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.670730 | 0.173 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.679717 | 0.168 |
| R-HSA-168256 | Immune System | 0.681698 | 0.166 |
| R-HSA-5617833 | Cilium Assembly | 0.683244 | 0.165 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.684993 | 0.164 |
| R-HSA-68877 | Mitotic Prometaphase | 0.688463 | 0.162 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.690183 | 0.161 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.703613 | 0.153 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.705251 | 0.152 |
| R-HSA-72172 | mRNA Splicing | 0.708499 | 0.150 |
| R-HSA-5357801 | Programmed Cell Death | 0.710111 | 0.149 |
| R-HSA-6805567 | Keratinization | 0.711713 | 0.148 |
| R-HSA-199991 | Membrane Trafficking | 0.713097 | 0.147 |
| R-HSA-372790 | Signaling by GPCR | 0.713131 | 0.147 |
| R-HSA-68882 | Mitotic Anaphase | 0.727261 | 0.138 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.728770 | 0.137 |
| R-HSA-8951664 | Neddylation | 0.734722 | 0.134 |
| R-HSA-162906 | HIV Infection | 0.743408 | 0.129 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.747646 | 0.126 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.747945 | 0.126 |
| R-HSA-72312 | rRNA processing | 0.750432 | 0.125 |
| R-HSA-168249 | Innate Immune System | 0.756723 | 0.121 |
| R-HSA-1640170 | Cell Cycle | 0.766283 | 0.116 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.770382 | 0.113 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.795689 | 0.099 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.806751 | 0.093 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.807824 | 0.093 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.809952 | 0.092 |
| R-HSA-9658195 | Leishmania infection | 0.809952 | 0.092 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.835096 | 0.078 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.837130 | 0.077 |
| R-HSA-1280218 | Adaptive Immune System | 0.842366 | 0.074 |
| R-HSA-556833 | Metabolism of lipids | 0.843434 | 0.074 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.847094 | 0.072 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.865640 | 0.063 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.869969 | 0.060 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.880438 | 0.055 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.914123 | 0.039 |
| R-HSA-5668914 | Diseases of metabolism | 0.916503 | 0.038 |
| R-HSA-211859 | Biological oxidations | 0.951405 | 0.022 |
| R-HSA-9679506 | SARS-CoV Infections | 0.959458 | 0.018 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.971652 | 0.012 |
| R-HSA-597592 | Post-translational protein modification | 0.985441 | 0.006 |
| R-HSA-9824446 | Viral Infection Pathways | 0.988439 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 0.994385 | 0.002 |
| R-HSA-5663205 | Infectious disease | 0.996678 | 0.001 |
| R-HSA-1643685 | Disease | 0.997246 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999221 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999858 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.796 | 0.462 | 1 | 0.861 |
CDK8 |
0.794 | 0.452 | 1 | 0.858 |
CLK3 |
0.793 | 0.384 | 1 | 0.756 |
KIS |
0.792 | 0.402 | 1 | 0.873 |
P38D |
0.791 | 0.506 | 1 | 0.851 |
P38B |
0.791 | 0.485 | 1 | 0.891 |
CDK18 |
0.790 | 0.466 | 1 | 0.836 |
ERK1 |
0.788 | 0.458 | 1 | 0.888 |
HIPK2 |
0.787 | 0.431 | 1 | 0.830 |
CDK7 |
0.787 | 0.421 | 1 | 0.851 |
ERK5 |
0.784 | 0.345 | 1 | 0.808 |
CDK3 |
0.783 | 0.440 | 1 | 0.826 |
P38A |
0.783 | 0.462 | 1 | 0.880 |
CDK17 |
0.783 | 0.454 | 1 | 0.819 |
CDK1 |
0.782 | 0.449 | 1 | 0.830 |
JNK2 |
0.782 | 0.455 | 1 | 0.862 |
HIPK4 |
0.782 | 0.345 | 1 | 0.741 |
P38G |
0.781 | 0.448 | 1 | 0.832 |
DYRK2 |
0.781 | 0.411 | 1 | 0.845 |
CDK16 |
0.780 | 0.458 | 1 | 0.816 |
CDK5 |
0.778 | 0.437 | 1 | 0.840 |
NLK |
0.777 | 0.384 | 1 | 0.793 |
JNK3 |
0.777 | 0.451 | 1 | 0.859 |
CDK13 |
0.775 | 0.395 | 1 | 0.851 |
HIPK1 |
0.775 | 0.399 | 1 | 0.841 |
DYRK4 |
0.772 | 0.400 | 1 | 0.851 |
CDK12 |
0.772 | 0.396 | 1 | 0.855 |
CDK14 |
0.771 | 0.443 | 1 | 0.843 |
ERK2 |
0.771 | 0.414 | 1 | 0.862 |
ICK |
0.768 | 0.275 | -3 | 0.739 |
SRPK1 |
0.767 | 0.200 | -3 | 0.644 |
DYRK1A |
0.767 | 0.353 | 1 | 0.834 |
MAK |
0.767 | 0.355 | -2 | 0.837 |
HIPK3 |
0.766 | 0.367 | 1 | 0.849 |
CDKL5 |
0.766 | 0.168 | -3 | 0.688 |
CDK9 |
0.765 | 0.380 | 1 | 0.861 |
DYRK1B |
0.763 | 0.377 | 1 | 0.845 |
CLK1 |
0.763 | 0.214 | -3 | 0.655 |
CDK10 |
0.762 | 0.393 | 1 | 0.840 |
PRKD1 |
0.762 | 0.159 | -3 | 0.741 |
MTOR |
0.761 | 0.065 | 1 | 0.658 |
COT |
0.761 | -0.025 | 2 | 0.783 |
NDR2 |
0.759 | 0.150 | -3 | 0.759 |
CLK4 |
0.759 | 0.194 | -3 | 0.660 |
JNK1 |
0.757 | 0.395 | 1 | 0.830 |
TBK1 |
0.757 | -0.006 | 1 | 0.548 |
CDKL1 |
0.757 | 0.099 | -3 | 0.694 |
CLK2 |
0.757 | 0.236 | -3 | 0.652 |
CDK2 |
0.755 | 0.305 | 1 | 0.803 |
PIM3 |
0.754 | 0.082 | -3 | 0.742 |
SRPK2 |
0.753 | 0.133 | -3 | 0.566 |
CDK6 |
0.753 | 0.392 | 1 | 0.847 |
RSK2 |
0.753 | 0.096 | -3 | 0.683 |
CDC7 |
0.753 | -0.035 | 1 | 0.505 |
PRPK |
0.753 | -0.024 | -1 | 0.417 |
DYRK3 |
0.752 | 0.277 | 1 | 0.826 |
IKKE |
0.751 | -0.046 | 1 | 0.549 |
P90RSK |
0.750 | 0.112 | -3 | 0.678 |
IKKB |
0.750 | -0.082 | -2 | 0.641 |
CDK4 |
0.750 | 0.384 | 1 | 0.842 |
PRKD2 |
0.749 | 0.049 | -3 | 0.700 |
MOS |
0.749 | -0.012 | 1 | 0.547 |
ATR |
0.748 | 0.023 | 1 | 0.558 |
MOK |
0.746 | 0.293 | 1 | 0.808 |
IKKA |
0.746 | 0.014 | -2 | 0.635 |
TGFBR2 |
0.746 | -0.032 | -2 | 0.686 |
MST4 |
0.745 | -0.029 | 2 | 0.801 |
RAF1 |
0.745 | -0.158 | 1 | 0.567 |
LATS2 |
0.744 | 0.090 | -5 | 0.686 |
SRPK3 |
0.744 | 0.113 | -3 | 0.602 |
BMPR2 |
0.744 | -0.178 | -2 | 0.767 |
NDR1 |
0.744 | 0.019 | -3 | 0.747 |
GRK1 |
0.744 | 0.040 | -2 | 0.682 |
SKMLCK |
0.743 | 0.024 | -2 | 0.781 |
PDHK1 |
0.743 | -0.121 | 1 | 0.608 |
WNK1 |
0.743 | -0.067 | -2 | 0.800 |
CAMK1B |
0.743 | -0.029 | -3 | 0.760 |
PIM1 |
0.743 | 0.078 | -3 | 0.682 |
PDHK4 |
0.743 | -0.162 | 1 | 0.604 |
CHAK2 |
0.743 | -0.016 | -1 | 0.413 |
NUAK2 |
0.743 | 0.021 | -3 | 0.746 |
CAMK2D |
0.742 | 0.031 | -3 | 0.745 |
PKCD |
0.742 | 0.038 | 2 | 0.707 |
AURC |
0.741 | 0.041 | -2 | 0.617 |
CAMK2G |
0.741 | -0.082 | 2 | 0.751 |
PRP4 |
0.741 | 0.206 | -3 | 0.693 |
PKN3 |
0.741 | -0.001 | -3 | 0.729 |
DSTYK |
0.740 | -0.183 | 2 | 0.791 |
RSK3 |
0.740 | 0.015 | -3 | 0.673 |
GCN2 |
0.739 | -0.201 | 2 | 0.694 |
RIPK3 |
0.739 | -0.100 | 3 | 0.742 |
BCKDK |
0.739 | -0.136 | -1 | 0.346 |
MAPKAPK2 |
0.738 | 0.030 | -3 | 0.654 |
CAMLCK |
0.738 | -0.011 | -2 | 0.766 |
NEK6 |
0.738 | -0.126 | -2 | 0.722 |
MAPKAPK3 |
0.738 | -0.009 | -3 | 0.690 |
NIK |
0.737 | -0.049 | -3 | 0.783 |
ULK2 |
0.737 | -0.205 | 2 | 0.677 |
LATS1 |
0.737 | 0.190 | -3 | 0.782 |
RSK4 |
0.736 | 0.093 | -3 | 0.656 |
MPSK1 |
0.736 | 0.177 | 1 | 0.545 |
MLK1 |
0.736 | -0.103 | 2 | 0.715 |
TSSK1 |
0.736 | 0.062 | -3 | 0.785 |
AMPKA1 |
0.736 | -0.017 | -3 | 0.761 |
PAK6 |
0.735 | 0.011 | -2 | 0.655 |
MLK3 |
0.734 | -0.001 | 2 | 0.661 |
DAPK2 |
0.734 | -0.026 | -3 | 0.764 |
GRK5 |
0.734 | -0.112 | -3 | 0.746 |
AMPKA2 |
0.733 | 0.009 | -3 | 0.732 |
MNK1 |
0.733 | 0.068 | -2 | 0.718 |
DNAPK |
0.733 | -0.017 | 1 | 0.524 |
PKN2 |
0.733 | -0.047 | -3 | 0.734 |
PKACG |
0.732 | -0.018 | -2 | 0.646 |
IRE2 |
0.732 | 0.008 | 2 | 0.651 |
MLK2 |
0.732 | -0.057 | 2 | 0.732 |
MARK4 |
0.731 | -0.044 | 4 | 0.794 |
ERK7 |
0.731 | 0.114 | 2 | 0.414 |
WNK3 |
0.731 | -0.209 | 1 | 0.550 |
PKG2 |
0.731 | 0.027 | -2 | 0.609 |
TSSK2 |
0.730 | 0.017 | -5 | 0.788 |
CAMK2A |
0.730 | 0.047 | 2 | 0.751 |
IRE1 |
0.730 | -0.077 | 1 | 0.521 |
HUNK |
0.730 | -0.120 | 2 | 0.686 |
PKCA |
0.730 | 0.020 | 2 | 0.644 |
NEK7 |
0.730 | -0.241 | -3 | 0.753 |
PRKD3 |
0.730 | -0.011 | -3 | 0.648 |
P70S6KB |
0.729 | -0.042 | -3 | 0.694 |
MNK2 |
0.729 | -0.052 | -2 | 0.716 |
CAMK2B |
0.729 | 0.006 | 2 | 0.734 |
NUAK1 |
0.729 | -0.001 | -3 | 0.701 |
MASTL |
0.728 | -0.087 | -2 | 0.688 |
PRKX |
0.728 | 0.051 | -3 | 0.600 |
PKACB |
0.728 | 0.034 | -2 | 0.609 |
ALK4 |
0.728 | -0.061 | -2 | 0.732 |
BMPR1B |
0.728 | -0.048 | 1 | 0.471 |
TGFBR1 |
0.727 | -0.058 | -2 | 0.706 |
AURB |
0.727 | 0.006 | -2 | 0.608 |
GRK6 |
0.727 | -0.122 | 1 | 0.522 |
VRK2 |
0.727 | 0.027 | 1 | 0.638 |
NEK9 |
0.726 | -0.198 | 2 | 0.742 |
GRK7 |
0.726 | -0.003 | 1 | 0.498 |
SMG1 |
0.726 | -0.075 | 1 | 0.523 |
PHKG1 |
0.725 | -0.054 | -3 | 0.730 |
ULK1 |
0.725 | -0.222 | -3 | 0.731 |
ATM |
0.725 | -0.101 | 1 | 0.498 |
PKR |
0.724 | -0.085 | 1 | 0.558 |
ANKRD3 |
0.724 | -0.214 | 1 | 0.589 |
PKCG |
0.724 | -0.017 | 2 | 0.650 |
GRK4 |
0.724 | -0.164 | -2 | 0.702 |
CHK1 |
0.724 | 0.057 | -3 | 0.767 |
PKCB |
0.724 | -0.022 | 2 | 0.659 |
AKT2 |
0.724 | 0.011 | -3 | 0.590 |
PAK1 |
0.724 | -0.054 | -2 | 0.734 |
MSK1 |
0.724 | 0.017 | -3 | 0.637 |
DLK |
0.724 | -0.186 | 1 | 0.555 |
TTBK2 |
0.724 | -0.161 | 2 | 0.597 |
FAM20C |
0.723 | -0.042 | 2 | 0.540 |
PAK3 |
0.723 | -0.076 | -2 | 0.716 |
RIPK1 |
0.723 | -0.221 | 1 | 0.532 |
PIM2 |
0.723 | 0.043 | -3 | 0.647 |
PKCZ |
0.722 | -0.045 | 2 | 0.678 |
NIM1 |
0.722 | -0.124 | 3 | 0.768 |
MSK2 |
0.721 | -0.033 | -3 | 0.629 |
GSK3A |
0.721 | 0.112 | 4 | 0.428 |
YSK4 |
0.721 | -0.093 | 1 | 0.538 |
SGK3 |
0.720 | -0.021 | -3 | 0.667 |
CAMK4 |
0.720 | -0.089 | -3 | 0.722 |
MELK |
0.720 | -0.071 | -3 | 0.713 |
QSK |
0.719 | -0.028 | 4 | 0.772 |
CHAK1 |
0.719 | -0.105 | 2 | 0.683 |
ACVR2A |
0.718 | -0.098 | -2 | 0.676 |
MLK4 |
0.718 | -0.102 | 2 | 0.614 |
PKCH |
0.718 | -0.043 | 2 | 0.626 |
AURA |
0.717 | -0.015 | -2 | 0.594 |
TLK2 |
0.717 | -0.124 | 1 | 0.516 |
PAK2 |
0.716 | -0.074 | -2 | 0.715 |
ALK2 |
0.716 | -0.090 | -2 | 0.705 |
NEK2 |
0.716 | -0.180 | 2 | 0.713 |
PKACA |
0.715 | 0.016 | -2 | 0.567 |
AKT1 |
0.715 | 0.005 | -3 | 0.614 |
MEKK1 |
0.715 | -0.102 | 1 | 0.579 |
PLK3 |
0.715 | -0.098 | 2 | 0.664 |
MEK1 |
0.714 | -0.191 | 2 | 0.744 |
MYLK4 |
0.714 | -0.053 | -2 | 0.693 |
PASK |
0.714 | 0.114 | -3 | 0.759 |
ACVR2B |
0.714 | -0.114 | -2 | 0.681 |
PLK1 |
0.714 | -0.192 | -2 | 0.672 |
IRAK4 |
0.714 | -0.099 | 1 | 0.537 |
PINK1 |
0.713 | -0.055 | 1 | 0.643 |
PHKG2 |
0.712 | -0.039 | -3 | 0.705 |
BUB1 |
0.712 | 0.086 | -5 | 0.722 |
MST3 |
0.712 | -0.052 | 2 | 0.754 |
QIK |
0.712 | -0.136 | -3 | 0.731 |
DCAMKL1 |
0.711 | -0.035 | -3 | 0.704 |
SSTK |
0.711 | 0.012 | 4 | 0.768 |
BRSK2 |
0.711 | -0.068 | -3 | 0.721 |
BMPR1A |
0.711 | -0.066 | 1 | 0.447 |
MAPKAPK5 |
0.711 | -0.123 | -3 | 0.600 |
TAO3 |
0.711 | -0.063 | 1 | 0.563 |
HRI |
0.711 | -0.185 | -2 | 0.719 |
PAK5 |
0.711 | -0.038 | -2 | 0.591 |
PAK4 |
0.711 | -0.024 | -2 | 0.607 |
SIK |
0.711 | -0.072 | -3 | 0.658 |
WNK4 |
0.710 | -0.144 | -2 | 0.787 |
PERK |
0.710 | -0.165 | -2 | 0.709 |
ZAK |
0.710 | -0.147 | 1 | 0.550 |
BRAF |
0.710 | -0.175 | -4 | 0.734 |
MEKK2 |
0.709 | -0.134 | 2 | 0.708 |
PKCT |
0.708 | -0.051 | 2 | 0.642 |
GSK3B |
0.708 | 0.013 | 4 | 0.421 |
GRK2 |
0.708 | -0.080 | -2 | 0.623 |
MARK3 |
0.708 | -0.060 | 4 | 0.722 |
BRSK1 |
0.707 | -0.069 | -3 | 0.694 |
MARK2 |
0.707 | -0.075 | 4 | 0.697 |
MEK5 |
0.707 | -0.194 | 2 | 0.722 |
TTBK1 |
0.707 | -0.135 | 2 | 0.519 |
SMMLCK |
0.707 | -0.050 | -3 | 0.710 |
NEK5 |
0.706 | -0.170 | 1 | 0.563 |
PKCI |
0.706 | -0.055 | 2 | 0.647 |
MEKK3 |
0.706 | -0.202 | 1 | 0.563 |
CK1E |
0.706 | -0.051 | -3 | 0.424 |
P70S6K |
0.706 | -0.045 | -3 | 0.599 |
GAK |
0.706 | 0.002 | 1 | 0.577 |
CK1G1 |
0.705 | -0.050 | -3 | 0.418 |
SBK |
0.705 | 0.063 | -3 | 0.492 |
PKCE |
0.705 | 0.006 | 2 | 0.638 |
PLK4 |
0.705 | -0.188 | 2 | 0.506 |
TAO2 |
0.704 | -0.071 | 2 | 0.764 |
AKT3 |
0.704 | 0.006 | -3 | 0.536 |
MAP3K15 |
0.704 | -0.026 | 1 | 0.554 |
KHS1 |
0.704 | 0.036 | 1 | 0.580 |
PDK1 |
0.703 | -0.056 | 1 | 0.567 |
HGK |
0.703 | -0.039 | 3 | 0.862 |
CAMK1G |
0.703 | -0.078 | -3 | 0.652 |
LKB1 |
0.703 | -0.091 | -3 | 0.746 |
DCAMKL2 |
0.703 | -0.073 | -3 | 0.728 |
MEKK6 |
0.702 | -0.064 | 1 | 0.589 |
TLK1 |
0.702 | -0.196 | -2 | 0.699 |
EEF2K |
0.701 | -0.016 | 3 | 0.834 |
TNIK |
0.701 | -0.028 | 3 | 0.864 |
GCK |
0.701 | -0.040 | 1 | 0.566 |
CK1D |
0.701 | -0.035 | -3 | 0.373 |
IRAK1 |
0.701 | -0.214 | -1 | 0.317 |
CAMK1D |
0.700 | -0.029 | -3 | 0.600 |
MINK |
0.699 | -0.080 | 1 | 0.570 |
HASPIN |
0.699 | -0.014 | -1 | 0.311 |
PKN1 |
0.699 | -0.037 | -3 | 0.624 |
NEK4 |
0.699 | -0.153 | 1 | 0.560 |
MARK1 |
0.698 | -0.107 | 4 | 0.742 |
DRAK1 |
0.698 | -0.185 | 1 | 0.440 |
DMPK1 |
0.698 | 0.067 | -3 | 0.675 |
PLK2 |
0.698 | -0.024 | -3 | 0.749 |
PBK |
0.697 | -0.001 | 1 | 0.557 |
SGK1 |
0.697 | -0.002 | -3 | 0.515 |
DAPK3 |
0.697 | -0.035 | -3 | 0.700 |
SNRK |
0.696 | -0.200 | 2 | 0.538 |
MRCKA |
0.696 | -0.003 | -3 | 0.661 |
NEK1 |
0.696 | -0.114 | 1 | 0.545 |
KHS2 |
0.696 | -0.015 | 1 | 0.579 |
GRK3 |
0.696 | -0.078 | -2 | 0.584 |
NEK11 |
0.695 | -0.190 | 1 | 0.573 |
MRCKB |
0.695 | -0.024 | -3 | 0.637 |
CAMKK2 |
0.694 | -0.179 | -2 | 0.663 |
HPK1 |
0.694 | -0.090 | 1 | 0.571 |
ROCK2 |
0.694 | 0.000 | -3 | 0.692 |
LOK |
0.694 | -0.090 | -2 | 0.636 |
NEK8 |
0.694 | -0.212 | 2 | 0.707 |
CK1A2 |
0.693 | -0.063 | -3 | 0.369 |
CAMKK1 |
0.693 | -0.234 | -2 | 0.658 |
PKG1 |
0.693 | -0.032 | -2 | 0.541 |
MST2 |
0.693 | -0.132 | 1 | 0.575 |
CHK2 |
0.692 | -0.041 | -3 | 0.547 |
LRRK2 |
0.691 | -0.092 | 2 | 0.733 |
CAMK1A |
0.691 | -0.024 | -3 | 0.571 |
SLK |
0.691 | -0.081 | -2 | 0.585 |
MST1 |
0.691 | -0.080 | 1 | 0.562 |
VRK1 |
0.691 | -0.138 | 2 | 0.750 |
PDHK3_TYR |
0.689 | 0.204 | 4 | 0.878 |
CK2A2 |
0.688 | -0.083 | 1 | 0.362 |
TAK1 |
0.688 | -0.206 | 1 | 0.534 |
YSK1 |
0.688 | -0.107 | 2 | 0.724 |
DAPK1 |
0.686 | -0.055 | -3 | 0.670 |
AAK1 |
0.686 | 0.087 | 1 | 0.478 |
CRIK |
0.686 | 0.007 | -3 | 0.624 |
BIKE |
0.685 | -0.000 | 1 | 0.519 |
RIPK2 |
0.683 | -0.218 | 1 | 0.523 |
ASK1 |
0.682 | -0.056 | 1 | 0.541 |
NEK3 |
0.682 | -0.167 | 1 | 0.573 |
LIMK2_TYR |
0.681 | 0.126 | -3 | 0.815 |
TTK |
0.681 | -0.072 | -2 | 0.701 |
TESK1_TYR |
0.679 | 0.077 | 3 | 0.872 |
PKMYT1_TYR |
0.679 | 0.113 | 3 | 0.842 |
MEK2 |
0.679 | -0.238 | 2 | 0.720 |
TAO1 |
0.679 | -0.088 | 1 | 0.536 |
CK2A1 |
0.677 | -0.093 | 1 | 0.341 |
ROCK1 |
0.676 | -0.044 | -3 | 0.653 |
PDHK4_TYR |
0.676 | 0.056 | 2 | 0.786 |
MYO3B |
0.675 | -0.080 | 2 | 0.742 |
MAP2K4_TYR |
0.674 | -0.043 | -1 | 0.412 |
STK33 |
0.673 | -0.195 | 2 | 0.492 |
MYO3A |
0.672 | -0.086 | 1 | 0.554 |
JAK1 |
0.672 | 0.067 | 1 | 0.568 |
MAP2K6_TYR |
0.672 | -0.051 | -1 | 0.413 |
JAK2 |
0.671 | -0.009 | 1 | 0.602 |
MAP2K7_TYR |
0.671 | -0.098 | 2 | 0.760 |
ROS1 |
0.671 | 0.033 | 3 | 0.787 |
OSR1 |
0.671 | -0.145 | 2 | 0.701 |
TYK2 |
0.670 | -0.047 | 1 | 0.582 |
RET |
0.669 | -0.090 | 1 | 0.575 |
PDHK1_TYR |
0.669 | -0.075 | -1 | 0.413 |
ALPHAK3 |
0.669 | -0.113 | -1 | 0.338 |
CSF1R |
0.668 | -0.033 | 3 | 0.790 |
TNNI3K_TYR |
0.668 | 0.048 | 1 | 0.633 |
MST1R |
0.668 | -0.092 | 3 | 0.818 |
ABL2 |
0.667 | -0.068 | -1 | 0.375 |
BMPR2_TYR |
0.667 | -0.122 | -1 | 0.369 |
FGR |
0.666 | 0.060 | 1 | 0.572 |
TYRO3 |
0.666 | -0.094 | 3 | 0.815 |
YES1 |
0.666 | -0.010 | -1 | 0.448 |
EPHB4 |
0.666 | -0.113 | -1 | 0.367 |
YANK3 |
0.665 | -0.055 | 2 | 0.316 |
EPHA6 |
0.665 | -0.116 | -1 | 0.364 |
LIMK1_TYR |
0.665 | -0.045 | 2 | 0.758 |
ABL1 |
0.664 | -0.067 | -1 | 0.373 |
PINK1_TYR |
0.664 | -0.177 | 1 | 0.561 |
TNK1 |
0.663 | 0.007 | 3 | 0.779 |
TNK2 |
0.663 | -0.033 | 3 | 0.773 |
LCK |
0.662 | -0.057 | -1 | 0.389 |
HCK |
0.661 | -0.097 | -1 | 0.388 |
CK1A |
0.661 | -0.074 | -3 | 0.287 |
DDR1 |
0.660 | -0.097 | 4 | 0.813 |
TXK |
0.659 | -0.089 | 1 | 0.514 |
BLK |
0.658 | -0.061 | -1 | 0.384 |
FER |
0.658 | -0.122 | 1 | 0.564 |
NEK10_TYR |
0.658 | -0.092 | 1 | 0.472 |
EPHB1 |
0.657 | -0.148 | 1 | 0.575 |
JAK3 |
0.657 | -0.147 | 1 | 0.546 |
INSRR |
0.656 | -0.105 | 3 | 0.760 |
ITK |
0.656 | -0.130 | -1 | 0.360 |
FGFR1 |
0.655 | -0.076 | 3 | 0.775 |
BMX |
0.655 | -0.112 | -1 | 0.330 |
SRMS |
0.655 | -0.148 | 1 | 0.544 |
KIT |
0.655 | -0.120 | 3 | 0.791 |
PDGFRB |
0.654 | -0.146 | 3 | 0.813 |
FGFR2 |
0.654 | -0.116 | 3 | 0.790 |
DDR2 |
0.654 | 0.039 | 3 | 0.747 |
STLK3 |
0.653 | -0.211 | 1 | 0.522 |
FYN |
0.653 | -0.057 | -1 | 0.396 |
TEC |
0.653 | -0.132 | -1 | 0.337 |
AXL |
0.652 | -0.145 | 3 | 0.783 |
BTK |
0.652 | -0.160 | -1 | 0.365 |
EPHB2 |
0.652 | -0.158 | -1 | 0.348 |
EPHA4 |
0.652 | -0.115 | 2 | 0.662 |
MERTK |
0.652 | -0.138 | 3 | 0.770 |
EPHB3 |
0.652 | -0.159 | -1 | 0.358 |
TEK |
0.652 | -0.087 | 3 | 0.752 |
ALK |
0.651 | -0.090 | 3 | 0.739 |
FLT3 |
0.651 | -0.146 | 3 | 0.802 |
PDGFRA |
0.651 | -0.122 | 3 | 0.816 |
KDR |
0.650 | -0.117 | 3 | 0.752 |
MET |
0.650 | -0.126 | 3 | 0.792 |
LTK |
0.649 | -0.110 | 3 | 0.744 |
WEE1_TYR |
0.648 | -0.101 | -1 | 0.339 |
PTK6 |
0.648 | -0.163 | -1 | 0.362 |
NTRK3 |
0.647 | -0.104 | -1 | 0.391 |
LYN |
0.647 | -0.098 | 3 | 0.713 |
NTRK2 |
0.646 | -0.160 | 3 | 0.784 |
EPHA7 |
0.646 | -0.137 | 2 | 0.647 |
INSR |
0.645 | -0.121 | 3 | 0.736 |
NTRK1 |
0.644 | -0.164 | -1 | 0.399 |
EPHA1 |
0.644 | -0.147 | 3 | 0.767 |
SRC |
0.644 | -0.079 | -1 | 0.403 |
FGFR3 |
0.643 | -0.134 | 3 | 0.766 |
PTK2B |
0.642 | -0.111 | -1 | 0.360 |
EPHA3 |
0.642 | -0.156 | 2 | 0.630 |
FRK |
0.641 | -0.163 | -1 | 0.376 |
CK1G3 |
0.639 | -0.087 | -3 | 0.241 |
EGFR |
0.639 | -0.115 | 1 | 0.452 |
FGFR4 |
0.638 | -0.117 | -1 | 0.349 |
ERBB2 |
0.638 | -0.187 | 1 | 0.513 |
MATK |
0.637 | -0.135 | -1 | 0.339 |
FLT1 |
0.637 | -0.188 | -1 | 0.357 |
CSK |
0.637 | -0.143 | 2 | 0.657 |
EPHA5 |
0.635 | -0.166 | 2 | 0.637 |
EPHA8 |
0.635 | -0.151 | -1 | 0.340 |
FLT4 |
0.634 | -0.199 | 3 | 0.739 |
YANK2 |
0.631 | -0.082 | 2 | 0.328 |
EPHA2 |
0.629 | -0.154 | -1 | 0.316 |
PTK2 |
0.629 | -0.114 | -1 | 0.321 |
IGF1R |
0.629 | -0.130 | 3 | 0.679 |
MUSK |
0.628 | -0.153 | 1 | 0.444 |
SYK |
0.627 | -0.132 | -1 | 0.331 |
ERBB4 |
0.622 | -0.128 | 1 | 0.458 |
FES |
0.621 | -0.141 | -1 | 0.325 |
CK1G2 |
0.618 | -0.096 | -3 | 0.334 |
ZAP70 |
0.611 | -0.114 | -1 | 0.288 |