Motif 400 (n=103)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYC7 | ZFP91-CNTF | S103 | ochoa | E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 91 homolog) | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000256|ARBA:ARBA00054990}. |
| A4UGR9 | XIRP2 | S2998 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A5PLL1 | ANKRD34B | S400 | ochoa | Ankyrin repeat domain-containing protein 34B | None |
| A6NHG4 | DDTL | S29 | ochoa | D-dopachrome decarboxylase-like protein (EC 4.1.1.-) (D-dopachrome tautomerase-like protein) | May have lyase activity. {ECO:0000305}. |
| A8MVW0 | FAM171A2 | S737 | ochoa | Protein FAM171A2 | None |
| E9PAV3 | NACA | S1429 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O14519 | CDK2AP1 | S26 | ochoa | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}. |
| O14994 | SYN3 | S457 | ochoa | Synapsin-3 (Synapsin III) | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
| O60343 | TBC1D4 | S108 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O75151 | PHF2 | S640 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75251 | NDUFS7 | S57 | ochoa | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 7.1.1.2) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit) | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:17275378). Essential for the catalytic activity of complex I (PubMed:17275378). {ECO:0000269|PubMed:17275378}. |
| O95235 | KIF20A | S685 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95789 | ZMYM6 | S399 | ochoa | Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| P00519 | ABL1 | S919 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P00918 | CA2 | S50 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
| P06401 | PGR | S554 | psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P0C7T5 | ATXN1L | S208 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P0DPH7 | TUBA3C | Y282 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | Y282 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10070 | GLI2 | S1014 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P27816 | MAP4 | S789 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27987 | ITPKB | S564 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P29353 | SHC1 | S388 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P30046 | DDT | S29 | ochoa | D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II) | Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). {ECO:0000269|PubMed:8267597, ECO:0000269|PubMed:9480844}. |
| P31629 | HIVEP2 | S73 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P40123 | CAP2 | S259 | ochoa | Adenylyl cyclase-associated protein 2 (CAP 2) | Involved in the regulation of actin polymerization. {ECO:0000269|PubMed:30518548}. |
| P48553 | TRAPPC10 | S685 | ochoa | Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) | Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. {ECO:0000269|PubMed:11805826, ECO:0000269|PubMed:31467083, ECO:0000269|PubMed:35298461}. |
| P48637 | GSS | S151 | ochoa | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}. |
| P50219 | MNX1 | S79 | ochoa | Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9) | Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity). {ECO:0000250|UniProtKB:Q9QZW9}. |
| P50851 | LRBA | S1787 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P68363 | TUBA1B | Y282 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | Y282 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q07157 | TJP1 | S1198 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12946 | FOXF1 | S335 | ochoa | Forkhead box protein F1 (Forkhead-related activator 1) (FREAC-1) (Forkhead-related protein FKHL5) (Forkhead-related transcription factor 1) | Probable transcription activator for a number of lung-specific genes. |
| Q13233 | MAP3K1 | S252 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13563 | PKD2 | S76 | ochoa|psp | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q13813 | SPTAN1 | S1031 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q15596 | NCOA2 | S1074 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q2Q1W2 | TRIM71 | S189 | ochoa | E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). {ECO:0000250|UniProtKB:Q1PSW8, ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:28431233, ECO:0000305|PubMed:24239284}. |
| Q3KQU3 | MAP7D1 | S368 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3L8U1 | CHD9 | S1754 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q5JPB2 | ZNF831 | S918 | ochoa | Zinc finger protein 831 | None |
| Q5PRF9 | SAMD4B | S594 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5SXM2 | SNAPC4 | S599 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5SXM2 | SNAPC4 | S1163 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5T7B8 | KIF24 | S1133 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5VWN6 | TASOR2 | S1541 | ochoa | Protein TASOR 2 | None |
| Q5XKK7 | FAM219B | S35 | ochoa | Protein FAM219B | None |
| Q68DK2 | ZFYVE26 | S1782 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
| Q69YQ0 | SPECC1L | S870 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6DN12 | MCTP2 | S51 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6P0Q8 | MAST2 | S1722 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P3S6 | FBXO42 | S393 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PEY2 | TUBA3E | Y282 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6VMQ6 | ATF7IP | S854 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZTU2 | EP400P1 | S174 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q70SY1 | CREB3L2 | S249 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. |
| Q71U36 | TUBA1A | Y282 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z2K8 | GPRIN1 | S106 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2T5 | TRMT1L | S68 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q86VR2 | RETREG3 | S435 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q86X02 | CDR2L | S318 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q86X51 | EZHIP | S412 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q8IWR0 | ZC3H7A | S316 | ochoa | Zinc finger CCCH domain-containing protein 7A | May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}. |
| Q8IWZ8 | SUGP1 | S411 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IY33 | MICALL2 | S660 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8N1G0 | ZNF687 | S369 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N1I0 | DOCK4 | S1810 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N3F8 | MICALL1 | S515 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3F8 | MICALL1 | S520 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8TAD8 | SNIP1 | S54 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8WX93 | PALLD | S728 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q92793 | CREBBP | S2078 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92908 | GATA6 | S268 | ochoa | Transcription factor GATA-6 (GATA-binding factor 6) | Transcriptional activator (PubMed:19666519, PubMed:22750565, PubMed:22824924, PubMed:27756709). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341). {ECO:0000250|UniProtKB:Q61169, ECO:0000269|PubMed:16968778, ECO:0000269|PubMed:19666519, ECO:0000269|PubMed:22750565, ECO:0000269|PubMed:22824924, ECO:0000269|PubMed:27756709, ECO:0000269|PubMed:33082341, ECO:0000269|PubMed:9315713}. |
| Q92922 | SMARCC1 | S330 | ochoa | SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96A73 | KIAA1191 | S251 | ochoa | Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa) | Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. |
| Q96JP5 | ZFP91 | S103 | ochoa | E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91) | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}. |
| Q96L91 | EP400 | S185 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96PM9 | ZNF385A | S162 | ochoa | Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) | RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {ECO:0000269|PubMed:17719541}. |
| Q99569 | PKP4 | S512 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q9BQE3 | TUBA1C | Y282 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BQQ3 | GORASP1 | S243 | ochoa | Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}. |
| Q9BTC0 | DIDO1 | S525 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BVN2 | RUSC1 | S831 | ochoa | AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network (PubMed:30262884). Signaling adapter which plays a role in neuronal differentiation (PubMed:15024033). Involved in regulation of NGF-dependent neurite outgrowth (PubMed:15024033). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (PubMed:15024033). Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (PubMed:19365808). {ECO:0000250|UniProtKB:Q8BG26, ECO:0000269|PubMed:15024033, ECO:0000269|PubMed:19365808, ECO:0000269|PubMed:30262884}. |
| Q9BXF6 | RAB11FIP5 | S332 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BY11 | PACSIN1 | S339 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
| Q9BY89 | KIAA1671 | S404 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9H4Z2 | ZNF335 | S1007 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H792 | PEAK1 | Y880 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9HB21 | PLEKHA1 | S299 | ochoa | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}. |
| Q9NUA8 | ZBTB40 | S216 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NY65 | TUBA8 | Y282 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NZB2 | FAM120A | S925 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9NZC9 | SMARCAL1 | S200 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9P2Y4 | ZNF219 | S700 | ochoa | Zinc finger protein 219 | Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}. |
| Q9UBP0 | SPAST | S270 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
| Q9UK80 | USP21 | S115 | ochoa | Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}. |
| Q9ULM3 | YEATS2 | S610 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UQB3 | CTNND2 | S534 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9Y210 | TRPC6 | S197 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y2L6 | FRMD4B | S677 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y2U8 | LEMD3 | S187 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y490 | TLN1 | S1643 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.598255e-11 | 10.585 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.537293e-11 | 10.596 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 9.520607e-12 | 11.021 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.350209e-11 | 10.870 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.082920e-10 | 9.965 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.874948e-10 | 9.541 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.309075e-10 | 9.366 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5.549994e-10 | 9.256 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.280903e-10 | 9.138 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.898403e-10 | 9.161 |
| R-HSA-190861 | Gap junction assembly | 1.230619e-09 | 8.910 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.635450e-09 | 8.786 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.731453e-09 | 8.762 |
| R-HSA-983189 | Kinesins | 3.151868e-09 | 8.501 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.292268e-09 | 8.483 |
| R-HSA-9646399 | Aggrephagy | 3.535081e-09 | 8.452 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.872743e-09 | 8.312 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.582382e-09 | 8.253 |
| R-HSA-190828 | Gap junction trafficking | 7.693338e-09 | 8.114 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.182697e-08 | 7.927 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.134353e-08 | 7.945 |
| R-HSA-437239 | Recycling pathway of L1 | 1.182697e-08 | 7.927 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.402933e-08 | 7.853 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.416271e-08 | 7.130 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.065162e-07 | 6.973 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.309979e-07 | 6.883 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.460535e-07 | 6.835 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.152230e-07 | 6.667 |
| R-HSA-9833482 | PKR-mediated signaling | 4.136199e-07 | 6.383 |
| R-HSA-373760 | L1CAM interactions | 7.296340e-07 | 6.137 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.893894e-07 | 6.103 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.893894e-07 | 6.103 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.523017e-07 | 6.069 |
| R-HSA-9663891 | Selective autophagy | 8.523017e-07 | 6.069 |
| R-HSA-391251 | Protein folding | 1.235129e-06 | 5.908 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.941378e-06 | 5.712 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.297129e-06 | 5.639 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.617146e-06 | 5.582 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.165069e-06 | 5.500 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.304102e-06 | 5.366 |
| R-HSA-5617833 | Cilium Assembly | 4.631745e-06 | 5.334 |
| R-HSA-5620924 | Intraflagellar transport | 4.828810e-06 | 5.316 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.942545e-06 | 5.158 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.472896e-06 | 5.024 |
| R-HSA-68882 | Mitotic Anaphase | 1.318125e-05 | 4.880 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.366470e-05 | 4.864 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.526494e-05 | 4.597 |
| R-HSA-1632852 | Macroautophagy | 2.890898e-05 | 4.539 |
| R-HSA-199991 | Membrane Trafficking | 4.434292e-05 | 4.353 |
| R-HSA-68886 | M Phase | 5.651572e-05 | 4.248 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.227203e-05 | 4.282 |
| R-HSA-9612973 | Autophagy | 5.663005e-05 | 4.247 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.720990e-05 | 4.112 |
| R-HSA-422475 | Axon guidance | 9.689870e-05 | 4.014 |
| R-HSA-1266738 | Developmental Biology | 1.086489e-04 | 3.964 |
| R-HSA-109582 | Hemostasis | 1.153317e-04 | 3.938 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.368588e-04 | 3.864 |
| R-HSA-69275 | G2/M Transition | 1.734660e-04 | 3.761 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.851676e-04 | 3.732 |
| R-HSA-9675108 | Nervous system development | 1.863700e-04 | 3.730 |
| R-HSA-68877 | Mitotic Prometaphase | 2.172892e-04 | 3.663 |
| R-HSA-9609690 | HCMV Early Events | 2.386656e-04 | 3.622 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 2.587678e-04 | 3.587 |
| R-HSA-9842663 | Signaling by LTK | 2.587678e-04 | 3.587 |
| R-HSA-2262752 | Cellular responses to stress | 2.830737e-04 | 3.548 |
| R-HSA-1640170 | Cell Cycle | 3.938281e-04 | 3.405 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.948957e-04 | 3.404 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.400519e-04 | 3.356 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.983606e-04 | 3.302 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.021686e-04 | 3.299 |
| R-HSA-9609646 | HCMV Infection | 1.050670e-03 | 2.979 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.198260e-03 | 2.921 |
| R-HSA-9758920 | Formation of lateral plate mesoderm | 1.722762e-03 | 2.764 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.722762e-03 | 2.764 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.643160e-03 | 2.578 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.643160e-03 | 2.578 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 2.665558e-03 | 2.574 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.215468e-03 | 2.493 |
| R-HSA-8939211 | ESR-mediated signaling | 3.427648e-03 | 2.465 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.800001e-03 | 2.420 |
| R-HSA-4839726 | Chromatin organization | 4.385056e-03 | 2.358 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 5.123241e-03 | 2.290 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 5.852608e-03 | 2.233 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.223264e-03 | 2.282 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.955783e-03 | 2.225 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.713782e-03 | 2.173 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.353490e-03 | 2.134 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 7.444318e-03 | 2.128 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 7.444318e-03 | 2.128 |
| R-HSA-9758941 | Gastrulation | 8.849035e-03 | 2.053 |
| R-HSA-9634597 | GPER1 signaling | 8.928254e-03 | 2.049 |
| R-HSA-3214847 | HATs acetylate histones | 9.830218e-03 | 2.007 |
| R-HSA-913531 | Interferon Signaling | 1.157841e-02 | 1.936 |
| R-HSA-112316 | Neuronal System | 1.180212e-02 | 1.928 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 1.666696e-02 | 1.778 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 1.788671e-02 | 1.747 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.548452e-02 | 1.810 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.741114e-02 | 1.759 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.804968e-02 | 1.744 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.788671e-02 | 1.747 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.498578e-02 | 1.824 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.678550e-02 | 1.775 |
| R-HSA-9707616 | Heme signaling | 1.617274e-02 | 1.791 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.004292e-02 | 1.698 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.048226e-02 | 1.689 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.073324e-02 | 1.683 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.176369e-02 | 1.662 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.437941e-02 | 1.613 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.452380e-02 | 1.610 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 2.595473e-02 | 1.586 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.595473e-02 | 1.586 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.607264e-02 | 1.584 |
| R-HSA-9659379 | Sensory processing of sound | 2.834964e-02 | 1.547 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.834964e-02 | 1.547 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.885927e-02 | 1.540 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.891547e-02 | 1.539 |
| R-HSA-5579006 | Defective GSS causes GSS deficiency | 3.687924e-02 | 1.433 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.918899e-02 | 1.407 |
| R-HSA-354192 | Integrin signaling | 3.521676e-02 | 1.453 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.359534e-02 | 1.474 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.998836e-02 | 1.398 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 3.854860e-02 | 1.414 |
| R-HSA-9733709 | Cardiogenesis | 3.521676e-02 | 1.453 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.044414e-02 | 1.516 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.874930e-02 | 1.412 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.359534e-02 | 1.474 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 3.175823e-02 | 1.498 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.002819e-02 | 1.522 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 4.025796e-02 | 1.395 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.025796e-02 | 1.395 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.143769e-02 | 1.383 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.199559e-02 | 1.377 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 4.409158e-02 | 1.356 |
| R-HSA-191650 | Regulation of gap junction activity | 4.409158e-02 | 1.356 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 4.409158e-02 | 1.356 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 4.409158e-02 | 1.356 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 4.409158e-02 | 1.356 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.551528e-02 | 1.342 |
| R-HSA-201556 | Signaling by ALK | 4.737300e-02 | 1.324 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.742341e-02 | 1.324 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.921864e-02 | 1.308 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 5.125036e-02 | 1.290 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 5.125036e-02 | 1.290 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 5.125036e-02 | 1.290 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.296804e-02 | 1.276 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 5.490827e-02 | 1.260 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.685413e-02 | 1.245 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 8.625446e-02 | 1.064 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 5.835597e-02 | 1.234 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.081700e-02 | 1.216 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 7.935765e-02 | 1.100 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 6.540879e-02 | 1.184 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 8.625446e-02 | 1.064 |
| R-HSA-8874211 | CREB3 factors activate genes | 6.540879e-02 | 1.184 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.168824e-02 | 1.145 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 7.240923e-02 | 1.140 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 8.625446e-02 | 1.064 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 8.416091e-02 | 1.075 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.438975e-02 | 1.074 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 8.640111e-02 | 1.063 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.935765e-02 | 1.100 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.625446e-02 | 1.064 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.081700e-02 | 1.216 |
| R-HSA-5654736 | Signaling by FGFR1 | 8.416091e-02 | 1.075 |
| R-HSA-75153 | Apoptotic execution phase | 6.283311e-02 | 1.202 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.669205e-02 | 1.115 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.930333e-02 | 1.049 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.930333e-02 | 1.049 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.930333e-02 | 1.049 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.070017e-02 | 1.042 |
| R-HSA-114608 | Platelet degranulation | 9.221759e-02 | 1.035 |
| R-HSA-74749 | Signal attenuation | 9.310002e-02 | 1.031 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.066389e-01 | 0.972 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.199774e-01 | 0.921 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.265723e-01 | 0.898 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.265723e-01 | 0.898 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.331183e-01 | 0.876 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.331183e-01 | 0.876 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.396156e-01 | 0.855 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.460645e-01 | 0.835 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.524656e-01 | 0.817 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.713846e-01 | 0.766 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 1.898847e-01 | 0.722 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.002051e-01 | 0.999 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.002051e-01 | 0.999 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.073235e-01 | 0.969 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.244276e-01 | 0.905 |
| R-HSA-380287 | Centrosome maturation | 1.294297e-01 | 0.888 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.370190e-01 | 0.863 |
| R-HSA-1989781 | PPARA activates gene expression | 1.419986e-01 | 0.848 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.199774e-01 | 0.921 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.454751e-01 | 0.837 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.713846e-01 | 0.766 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.199774e-01 | 0.921 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.331183e-01 | 0.876 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.460645e-01 | 0.835 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.133330e-01 | 0.946 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.066389e-01 | 0.972 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.066389e-01 | 0.972 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.133330e-01 | 0.946 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.199774e-01 | 0.921 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.588190e-01 | 0.799 |
| R-HSA-167044 | Signalling to RAS | 1.775974e-01 | 0.751 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.898847e-01 | 0.722 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.133330e-01 | 0.946 |
| R-HSA-8851805 | MET activates RAS signaling | 1.133330e-01 | 0.946 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.898847e-01 | 0.722 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.219449e-01 | 0.914 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.133330e-01 | 0.946 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.775974e-01 | 0.751 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.524783e-01 | 0.817 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.170173e-01 | 0.932 |
| R-HSA-9843745 | Adipogenesis | 9.967360e-02 | 1.001 |
| R-HSA-9909396 | Circadian clock | 1.011934e-01 | 0.995 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.460645e-01 | 0.835 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.588190e-01 | 0.799 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.066389e-01 | 0.972 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 1.133330e-01 | 0.946 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.396156e-01 | 0.855 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 1.651253e-01 | 0.782 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.524656e-01 | 0.817 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.524656e-01 | 0.817 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 1.651253e-01 | 0.782 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.524656e-01 | 0.817 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.588190e-01 | 0.799 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.460645e-01 | 0.835 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.775974e-01 | 0.751 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.775974e-01 | 0.751 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.870039e-01 | 0.728 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.133330e-01 | 0.946 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.588190e-01 | 0.799 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.837640e-01 | 0.736 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.396156e-01 | 0.855 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.396156e-01 | 0.855 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 1.775974e-01 | 0.751 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.775974e-01 | 0.751 |
| R-HSA-174403 | Glutathione synthesis and recycling | 1.837640e-01 | 0.736 |
| R-HSA-9020558 | Interleukin-2 signaling | 9.989472e-02 | 1.000 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.421325e-01 | 0.847 |
| R-HSA-166520 | Signaling by NTRKs | 1.300622e-01 | 0.886 |
| R-HSA-373753 | Nephrin family interactions | 1.713846e-01 | 0.766 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.435878e-01 | 0.843 |
| R-HSA-210993 | Tie2 Signaling | 1.588190e-01 | 0.799 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.898847e-01 | 0.722 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.027224e-01 | 0.988 |
| R-HSA-418555 | G alpha (s) signalling events | 1.723950e-01 | 0.763 |
| R-HSA-162582 | Signal Transduction | 9.969437e-02 | 1.001 |
| R-HSA-597592 | Post-translational protein modification | 1.263490e-01 | 0.898 |
| R-HSA-2028269 | Signaling by Hippo | 1.524656e-01 | 0.817 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.735828e-01 | 0.760 |
| R-HSA-1280218 | Adaptive Immune System | 1.057312e-01 | 0.976 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 1.959599e-01 | 0.708 |
| R-HSA-190236 | Signaling by FGFR | 1.978437e-01 | 0.704 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.019899e-01 | 0.695 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.019899e-01 | 0.695 |
| R-HSA-429947 | Deadenylation of mRNA | 2.019899e-01 | 0.695 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.019899e-01 | 0.695 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.079751e-01 | 0.682 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.079751e-01 | 0.682 |
| R-HSA-3214842 | HDMs demethylate histones | 2.079751e-01 | 0.682 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.087590e-01 | 0.680 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.139158e-01 | 0.670 |
| R-HSA-525793 | Myogenesis | 2.139158e-01 | 0.670 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.139158e-01 | 0.670 |
| R-HSA-3295583 | TRP channels | 2.139158e-01 | 0.670 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.142406e-01 | 0.669 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.169867e-01 | 0.664 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.169867e-01 | 0.664 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.198122e-01 | 0.658 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.198122e-01 | 0.658 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.198122e-01 | 0.658 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.198122e-01 | 0.658 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.252435e-01 | 0.647 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.252435e-01 | 0.647 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.256648e-01 | 0.647 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.280013e-01 | 0.642 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.314739e-01 | 0.635 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.314739e-01 | 0.635 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.314739e-01 | 0.635 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.314739e-01 | 0.635 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.314739e-01 | 0.635 |
| R-HSA-2424491 | DAP12 signaling | 2.372397e-01 | 0.625 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.372397e-01 | 0.625 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.372397e-01 | 0.625 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.372397e-01 | 0.625 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 2.390552e-01 | 0.622 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.429626e-01 | 0.614 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.445932e-01 | 0.612 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.542810e-01 | 0.595 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.542810e-01 | 0.595 |
| R-HSA-159418 | Recycling of bile acids and salts | 2.542810e-01 | 0.595 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.542810e-01 | 0.595 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.542810e-01 | 0.595 |
| R-HSA-390522 | Striated Muscle Contraction | 2.598771e-01 | 0.585 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 2.598771e-01 | 0.585 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 2.598771e-01 | 0.585 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.640096e-01 | 0.578 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.654316e-01 | 0.576 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.654316e-01 | 0.576 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 2.654316e-01 | 0.576 |
| R-HSA-68875 | Mitotic Prophase | 2.667854e-01 | 0.574 |
| R-HSA-187687 | Signalling to ERKs | 2.709447e-01 | 0.567 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.709447e-01 | 0.567 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.709447e-01 | 0.567 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.751125e-01 | 0.560 |
| R-HSA-8853659 | RET signaling | 2.764167e-01 | 0.558 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.764167e-01 | 0.558 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.764167e-01 | 0.558 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.818481e-01 | 0.550 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 2.818481e-01 | 0.550 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.872390e-01 | 0.542 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.979007e-01 | 0.526 |
| R-HSA-3371568 | Attenuation phase | 2.979007e-01 | 0.526 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.031721e-01 | 0.518 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.031721e-01 | 0.518 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.031721e-01 | 0.518 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.084042e-01 | 0.511 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.084042e-01 | 0.511 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.084042e-01 | 0.511 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.135974e-01 | 0.504 |
| R-HSA-2172127 | DAP12 interactions | 3.238680e-01 | 0.490 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.238680e-01 | 0.490 |
| R-HSA-5683826 | Surfactant metabolism | 3.238680e-01 | 0.490 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.238680e-01 | 0.490 |
| R-HSA-69236 | G1 Phase | 3.238680e-01 | 0.490 |
| R-HSA-373752 | Netrin-1 signaling | 3.238680e-01 | 0.490 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.238680e-01 | 0.490 |
| R-HSA-74160 | Gene expression (Transcription) | 3.244120e-01 | 0.489 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.289460e-01 | 0.483 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.339861e-01 | 0.476 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.339861e-01 | 0.476 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.339861e-01 | 0.476 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.339861e-01 | 0.476 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.339861e-01 | 0.476 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.418401e-01 | 0.466 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.488825e-01 | 0.457 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.488825e-01 | 0.457 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.488825e-01 | 0.457 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.586293e-01 | 0.445 |
| R-HSA-9824446 | Viral Infection Pathways | 3.615711e-01 | 0.442 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.634483e-01 | 0.440 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.680298e-01 | 0.434 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.682314e-01 | 0.434 |
| R-HSA-1221632 | Meiotic synapsis | 3.682314e-01 | 0.434 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.766231e-01 | 0.424 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.776910e-01 | 0.423 |
| R-HSA-177929 | Signaling by EGFR | 3.823679e-01 | 0.418 |
| R-HSA-75893 | TNF signaling | 3.823679e-01 | 0.418 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.870100e-01 | 0.412 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.870663e-01 | 0.412 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.916175e-01 | 0.407 |
| R-HSA-109581 | Apoptosis | 3.923670e-01 | 0.406 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.961907e-01 | 0.402 |
| R-HSA-186712 | Regulation of beta-cell development | 3.961907e-01 | 0.402 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.961907e-01 | 0.402 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.007297e-01 | 0.397 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.007297e-01 | 0.397 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.007297e-01 | 0.397 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.007297e-01 | 0.397 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.007297e-01 | 0.397 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.007297e-01 | 0.397 |
| R-HSA-156590 | Glutathione conjugation | 4.007297e-01 | 0.397 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.007297e-01 | 0.397 |
| R-HSA-212436 | Generic Transcription Pathway | 4.022381e-01 | 0.396 |
| R-HSA-211976 | Endogenous sterols | 4.052349e-01 | 0.392 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.052349e-01 | 0.392 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.097066e-01 | 0.388 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.097066e-01 | 0.388 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.097066e-01 | 0.388 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.136663e-01 | 0.383 |
| R-HSA-6799198 | Complex I biogenesis | 4.141448e-01 | 0.383 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.141448e-01 | 0.383 |
| R-HSA-373755 | Semaphorin interactions | 4.141448e-01 | 0.383 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.185500e-01 | 0.378 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.229223e-01 | 0.374 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.229223e-01 | 0.374 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.237257e-01 | 0.373 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.272621e-01 | 0.369 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 4.315694e-01 | 0.365 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.315694e-01 | 0.365 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.403209e-01 | 0.356 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.442996e-01 | 0.352 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.442996e-01 | 0.352 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.484799e-01 | 0.348 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.484799e-01 | 0.348 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.608345e-01 | 0.336 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 4.648913e-01 | 0.333 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.689180e-01 | 0.329 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.765246e-01 | 0.322 |
| R-HSA-8957322 | Metabolism of steroids | 4.793530e-01 | 0.319 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 4.808184e-01 | 0.318 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 4.808184e-01 | 0.318 |
| R-HSA-6806834 | Signaling by MET | 4.847261e-01 | 0.315 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.847261e-01 | 0.315 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.978584e-01 | 0.303 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.982533e-01 | 0.303 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.982533e-01 | 0.303 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.000674e-01 | 0.301 |
| R-HSA-72172 | mRNA Splicing | 5.030043e-01 | 0.298 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.038315e-01 | 0.298 |
| R-HSA-1500620 | Meiosis | 5.038315e-01 | 0.298 |
| R-HSA-5357801 | Programmed Cell Death | 5.053691e-01 | 0.296 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.075674e-01 | 0.295 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.112754e-01 | 0.291 |
| R-HSA-397014 | Muscle contraction | 5.217194e-01 | 0.283 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.240259e-01 | 0.281 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.258326e-01 | 0.279 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.294042e-01 | 0.276 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.364675e-01 | 0.270 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.536691e-01 | 0.257 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.570327e-01 | 0.254 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.577274e-01 | 0.254 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.603712e-01 | 0.252 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.603712e-01 | 0.252 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.603712e-01 | 0.252 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.636847e-01 | 0.249 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.636847e-01 | 0.249 |
| R-HSA-392499 | Metabolism of proteins | 5.650854e-01 | 0.248 |
| R-HSA-1483255 | PI Metabolism | 5.734773e-01 | 0.241 |
| R-HSA-9833110 | RSV-host interactions | 5.830519e-01 | 0.234 |
| R-HSA-418346 | Platelet homeostasis | 5.893162e-01 | 0.230 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.954872e-01 | 0.225 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.954872e-01 | 0.225 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.985381e-01 | 0.223 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.015662e-01 | 0.221 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.075546e-01 | 0.216 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.105152e-01 | 0.214 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.105152e-01 | 0.214 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.134537e-01 | 0.212 |
| R-HSA-5688426 | Deubiquitination | 6.140677e-01 | 0.212 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.192649e-01 | 0.208 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.221379e-01 | 0.206 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.278196e-01 | 0.202 |
| R-HSA-5693538 | Homology Directed Repair | 6.306285e-01 | 0.200 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.334165e-01 | 0.198 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.334165e-01 | 0.198 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.389300e-01 | 0.195 |
| R-HSA-3371556 | Cellular response to heat stress | 6.389300e-01 | 0.195 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.416558e-01 | 0.193 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.416558e-01 | 0.193 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.470463e-01 | 0.189 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.594492e-01 | 0.181 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.601734e-01 | 0.180 |
| R-HSA-1474165 | Reproduction | 6.678160e-01 | 0.175 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.873730e-01 | 0.163 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.944087e-01 | 0.158 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.944087e-01 | 0.158 |
| R-HSA-9664407 | Parasite infection | 6.944087e-01 | 0.158 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.967189e-01 | 0.157 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.012873e-01 | 0.154 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.035459e-01 | 0.153 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.102205e-01 | 0.149 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.145873e-01 | 0.146 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.188887e-01 | 0.143 |
| R-HSA-1500931 | Cell-Cell communication | 7.209883e-01 | 0.142 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.210153e-01 | 0.142 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.252207e-01 | 0.140 |
| R-HSA-73887 | Death Receptor Signaling | 7.272997e-01 | 0.138 |
| R-HSA-5663205 | Infectious disease | 7.507647e-01 | 0.124 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 7.529490e-01 | 0.123 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.621640e-01 | 0.118 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.639656e-01 | 0.117 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.675285e-01 | 0.115 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.677850e-01 | 0.115 |
| R-HSA-611105 | Respiratory electron transport | 7.744949e-01 | 0.111 |
| R-HSA-2559583 | Cellular Senescence | 7.779000e-01 | 0.109 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.829124e-01 | 0.106 |
| R-HSA-983712 | Ion channel transport | 7.926030e-01 | 0.101 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.957369e-01 | 0.099 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.033676e-01 | 0.095 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.092681e-01 | 0.092 |
| R-HSA-428157 | Sphingolipid metabolism | 8.107156e-01 | 0.091 |
| R-HSA-6805567 | Keratinization | 8.191744e-01 | 0.087 |
| R-HSA-418990 | Adherens junctions interactions | 8.349835e-01 | 0.078 |
| R-HSA-388396 | GPCR downstream signalling | 8.531765e-01 | 0.069 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.572566e-01 | 0.067 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.594202e-01 | 0.066 |
| R-HSA-157118 | Signaling by NOTCH | 8.604897e-01 | 0.065 |
| R-HSA-168256 | Immune System | 8.606081e-01 | 0.065 |
| R-HSA-421270 | Cell-cell junction organization | 8.717352e-01 | 0.060 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.765449e-01 | 0.057 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.784184e-01 | 0.056 |
| R-HSA-416476 | G alpha (q) signalling events | 8.838711e-01 | 0.054 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 8.956692e-01 | 0.048 |
| R-HSA-446728 | Cell junction organization | 8.956692e-01 | 0.048 |
| R-HSA-9658195 | Leishmania infection | 8.980383e-01 | 0.047 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.980383e-01 | 0.047 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.988161e-01 | 0.046 |
| R-HSA-372790 | Signaling by GPCR | 9.011484e-01 | 0.045 |
| R-HSA-1483257 | Phospholipid metabolism | 9.084076e-01 | 0.042 |
| R-HSA-195721 | Signaling by WNT | 9.104897e-01 | 0.041 |
| R-HSA-211859 | Biological oxidations | 9.182263e-01 | 0.037 |
| R-HSA-1643685 | Disease | 9.259799e-01 | 0.033 |
| R-HSA-9679506 | SARS-CoV Infections | 9.331131e-01 | 0.030 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.356532e-01 | 0.029 |
| R-HSA-73894 | DNA Repair | 9.444015e-01 | 0.025 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.537844e-01 | 0.021 |
| R-HSA-8953854 | Metabolism of RNA | 9.586578e-01 | 0.018 |
| R-HSA-5668914 | Diseases of metabolism | 9.670921e-01 | 0.015 |
| R-HSA-6798695 | Neutrophil degranulation | 9.739084e-01 | 0.011 |
| R-HSA-168249 | Innate Immune System | 9.777264e-01 | 0.010 |
| R-HSA-556833 | Metabolism of lipids | 9.906799e-01 | 0.004 |
| R-HSA-449147 | Signaling by Interleukins | 9.929461e-01 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 9.962016e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 9.966310e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999965e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.758 | 0.354 | 1 | 0.873 |
CLK3 |
0.742 | 0.212 | 1 | 0.856 |
HIPK4 |
0.738 | 0.207 | 1 | 0.866 |
SRPK1 |
0.737 | 0.169 | -3 | 0.753 |
HIPK2 |
0.733 | 0.258 | 1 | 0.834 |
COT |
0.731 | 0.069 | 2 | 0.742 |
NLK |
0.728 | 0.211 | 1 | 0.882 |
CDK18 |
0.728 | 0.248 | 1 | 0.836 |
CDK19 |
0.727 | 0.225 | 1 | 0.838 |
CDK8 |
0.727 | 0.216 | 1 | 0.858 |
PRKD1 |
0.726 | 0.120 | -3 | 0.805 |
HIPK1 |
0.726 | 0.245 | 1 | 0.875 |
DYRK2 |
0.726 | 0.223 | 1 | 0.861 |
CDK1 |
0.725 | 0.249 | 1 | 0.843 |
PIM3 |
0.724 | 0.078 | -3 | 0.815 |
JNK2 |
0.724 | 0.259 | 1 | 0.838 |
CDK7 |
0.723 | 0.205 | 1 | 0.865 |
CDK5 |
0.723 | 0.234 | 1 | 0.869 |
NDR2 |
0.722 | 0.098 | -3 | 0.808 |
SRPK2 |
0.722 | 0.115 | -3 | 0.683 |
JNK3 |
0.721 | 0.261 | 1 | 0.855 |
MOS |
0.720 | 0.145 | 1 | 0.726 |
GRK1 |
0.720 | 0.204 | -2 | 0.534 |
ERK5 |
0.719 | 0.114 | 1 | 0.796 |
CDK17 |
0.719 | 0.242 | 1 | 0.800 |
MARK4 |
0.719 | 0.115 | 4 | 0.827 |
CDK3 |
0.718 | 0.231 | 1 | 0.812 |
SRPK3 |
0.718 | 0.120 | -3 | 0.730 |
CLK2 |
0.718 | 0.153 | -3 | 0.746 |
ICK |
0.718 | 0.115 | -3 | 0.816 |
AURC |
0.718 | 0.009 | -2 | 0.317 |
ATR |
0.717 | 0.055 | 1 | 0.756 |
P38G |
0.717 | 0.246 | 1 | 0.797 |
P38B |
0.717 | 0.232 | 1 | 0.831 |
CDKL5 |
0.716 | 0.057 | -3 | 0.782 |
MTOR |
0.716 | 0.003 | 1 | 0.748 |
RSK2 |
0.716 | 0.060 | -3 | 0.766 |
P38D |
0.716 | 0.255 | 1 | 0.814 |
PRKD2 |
0.716 | 0.039 | -3 | 0.755 |
ERK1 |
0.716 | 0.227 | 1 | 0.831 |
CDKL1 |
0.715 | 0.052 | -3 | 0.793 |
PRPK |
0.715 | 0.008 | -1 | 0.524 |
IKKB |
0.715 | -0.040 | -2 | 0.338 |
DYRK1A |
0.715 | 0.192 | 1 | 0.883 |
PIM1 |
0.714 | 0.064 | -3 | 0.766 |
CDC7 |
0.714 | -0.009 | 1 | 0.672 |
AMPKA1 |
0.714 | 0.081 | -3 | 0.817 |
CDK16 |
0.714 | 0.230 | 1 | 0.816 |
CDK13 |
0.714 | 0.196 | 1 | 0.857 |
HIPK3 |
0.714 | 0.206 | 1 | 0.859 |
CDK14 |
0.713 | 0.231 | 1 | 0.857 |
SKMLCK |
0.713 | 0.057 | -2 | 0.410 |
P90RSK |
0.713 | 0.070 | -3 | 0.765 |
NUAK2 |
0.712 | 0.054 | -3 | 0.812 |
TSSK1 |
0.712 | 0.094 | -3 | 0.830 |
P38A |
0.712 | 0.208 | 1 | 0.860 |
PKACG |
0.711 | 0.004 | -2 | 0.388 |
CDK10 |
0.711 | 0.218 | 1 | 0.851 |
CDK12 |
0.710 | 0.201 | 1 | 0.843 |
AMPKA2 |
0.710 | 0.073 | -3 | 0.792 |
RSK3 |
0.710 | 0.028 | -3 | 0.772 |
DYRK4 |
0.710 | 0.214 | 1 | 0.837 |
CDK9 |
0.710 | 0.196 | 1 | 0.856 |
NDR1 |
0.710 | 0.013 | -3 | 0.807 |
DYRK1B |
0.710 | 0.206 | 1 | 0.843 |
QSK |
0.710 | 0.101 | 4 | 0.831 |
PKACB |
0.710 | 0.025 | -2 | 0.332 |
TGFBR2 |
0.710 | -0.008 | -2 | 0.377 |
CAMK1B |
0.709 | -0.012 | -3 | 0.835 |
MAK |
0.708 | 0.169 | -2 | 0.317 |
CHAK2 |
0.708 | -0.011 | -1 | 0.484 |
IKKA |
0.708 | 0.012 | -2 | 0.339 |
PRKX |
0.708 | 0.043 | -3 | 0.675 |
TBK1 |
0.708 | -0.038 | 1 | 0.621 |
LATS2 |
0.707 | 0.038 | -5 | 0.710 |
CLK4 |
0.707 | 0.085 | -3 | 0.754 |
PKG2 |
0.707 | 0.016 | -2 | 0.348 |
CLK1 |
0.707 | 0.099 | -3 | 0.742 |
BMPR2 |
0.706 | -0.093 | -2 | 0.395 |
PDHK4 |
0.705 | -0.146 | 1 | 0.747 |
RAF1 |
0.705 | -0.090 | 1 | 0.697 |
MST4 |
0.705 | -0.021 | 2 | 0.714 |
GCN2 |
0.705 | -0.098 | 2 | 0.651 |
MARK3 |
0.704 | 0.111 | 4 | 0.819 |
TSSK2 |
0.704 | 0.041 | -5 | 0.795 |
WNK1 |
0.704 | -0.057 | -2 | 0.403 |
IKKE |
0.704 | -0.063 | 1 | 0.621 |
PKN2 |
0.704 | -0.012 | -3 | 0.810 |
DSTYK |
0.704 | -0.049 | 2 | 0.746 |
PKN3 |
0.704 | 0.003 | -3 | 0.799 |
PKCD |
0.704 | -0.002 | 2 | 0.636 |
CAMLCK |
0.703 | -0.028 | -2 | 0.377 |
NIK |
0.702 | -0.039 | -3 | 0.843 |
CDK2 |
0.702 | 0.150 | 1 | 0.859 |
DYRK3 |
0.702 | 0.140 | 1 | 0.859 |
SIK |
0.702 | 0.051 | -3 | 0.744 |
ERK2 |
0.702 | 0.196 | 1 | 0.866 |
RSK4 |
0.702 | 0.066 | -3 | 0.733 |
PRKD3 |
0.702 | 0.016 | -3 | 0.751 |
MPSK1 |
0.701 | 0.166 | 1 | 0.716 |
NUAK1 |
0.701 | 0.030 | -3 | 0.771 |
FAM20C |
0.701 | 0.075 | 2 | 0.667 |
GRK7 |
0.701 | 0.110 | 1 | 0.653 |
NEK6 |
0.701 | -0.089 | -2 | 0.367 |
MAPKAPK3 |
0.701 | -0.020 | -3 | 0.761 |
MARK2 |
0.701 | 0.104 | 4 | 0.787 |
LATS1 |
0.701 | 0.111 | -3 | 0.816 |
CAMK2D |
0.700 | -0.022 | -3 | 0.806 |
JNK1 |
0.700 | 0.224 | 1 | 0.830 |
MAPKAPK2 |
0.700 | 0.015 | -3 | 0.725 |
DAPK2 |
0.700 | -0.025 | -3 | 0.835 |
AURB |
0.700 | -0.028 | -2 | 0.306 |
ULK2 |
0.699 | -0.149 | 2 | 0.648 |
CAMK2G |
0.699 | -0.081 | 2 | 0.705 |
QIK |
0.699 | -0.002 | -3 | 0.801 |
CDK6 |
0.699 | 0.209 | 1 | 0.846 |
AKT2 |
0.699 | 0.029 | -3 | 0.692 |
GRK5 |
0.699 | -0.064 | -3 | 0.802 |
SSTK |
0.698 | 0.094 | 4 | 0.787 |
BMPR1B |
0.698 | 0.052 | 1 | 0.606 |
PIM2 |
0.698 | 0.051 | -3 | 0.739 |
PDHK1 |
0.698 | -0.172 | 1 | 0.732 |
MLK2 |
0.698 | -0.045 | 2 | 0.676 |
PKCB |
0.698 | 0.001 | 2 | 0.578 |
P70S6KB |
0.698 | -0.020 | -3 | 0.778 |
MASTL |
0.697 | -0.052 | -2 | 0.364 |
MLK1 |
0.697 | -0.065 | 2 | 0.654 |
HUNK |
0.697 | -0.001 | 2 | 0.641 |
RIPK3 |
0.697 | -0.059 | 3 | 0.698 |
IRE1 |
0.696 | -0.034 | 1 | 0.688 |
MELK |
0.696 | -0.010 | -3 | 0.779 |
MNK1 |
0.696 | 0.002 | -2 | 0.355 |
SGK3 |
0.695 | 0.010 | -3 | 0.759 |
NIM1 |
0.695 | -0.048 | 3 | 0.729 |
NEK7 |
0.694 | -0.150 | -3 | 0.808 |
MNK2 |
0.694 | -0.067 | -2 | 0.335 |
PKACA |
0.694 | 0.005 | -2 | 0.313 |
MOK |
0.694 | 0.143 | 1 | 0.840 |
PAK1 |
0.694 | -0.056 | -2 | 0.351 |
ATM |
0.693 | -0.008 | 1 | 0.691 |
PKCA |
0.693 | -0.016 | 2 | 0.570 |
BRSK1 |
0.693 | 0.026 | -3 | 0.779 |
PAK3 |
0.693 | -0.071 | -2 | 0.340 |
CDK4 |
0.693 | 0.193 | 1 | 0.842 |
IRE2 |
0.693 | -0.010 | 2 | 0.627 |
TGFBR1 |
0.693 | -0.001 | -2 | 0.401 |
SMG1 |
0.692 | -0.028 | 1 | 0.724 |
PRP4 |
0.692 | 0.095 | -3 | 0.712 |
WNK3 |
0.692 | -0.163 | 1 | 0.705 |
CAMK2A |
0.691 | 0.001 | 2 | 0.682 |
GRK4 |
0.691 | 0.007 | -2 | 0.481 |
MLK3 |
0.691 | -0.041 | 2 | 0.579 |
MSK1 |
0.691 | -0.008 | -3 | 0.746 |
PKCG |
0.691 | -0.030 | 2 | 0.565 |
BRSK2 |
0.691 | 0.017 | -3 | 0.786 |
TTBK2 |
0.691 | -0.014 | 2 | 0.560 |
BCKDK |
0.691 | -0.142 | -1 | 0.435 |
MARK1 |
0.691 | 0.050 | 4 | 0.808 |
MSK2 |
0.690 | -0.030 | -3 | 0.743 |
CK1E |
0.690 | 0.084 | -3 | 0.486 |
PKCZ |
0.689 | -0.042 | 2 | 0.629 |
ALK4 |
0.689 | -0.025 | -2 | 0.402 |
GRK2 |
0.689 | 0.021 | -2 | 0.419 |
CAMK2B |
0.689 | -0.025 | 2 | 0.700 |
CAMK4 |
0.688 | -0.074 | -3 | 0.786 |
RIPK1 |
0.688 | -0.110 | 1 | 0.697 |
MYLK4 |
0.688 | -0.034 | -2 | 0.370 |
VRK2 |
0.687 | -0.028 | 1 | 0.780 |
DNAPK |
0.687 | -0.006 | 1 | 0.659 |
NEK9 |
0.687 | -0.176 | 2 | 0.692 |
CHK1 |
0.687 | -0.003 | -3 | 0.800 |
PAK6 |
0.687 | -0.065 | -2 | 0.273 |
CHAK1 |
0.687 | -0.074 | 2 | 0.642 |
PINK1 |
0.686 | -0.042 | 1 | 0.823 |
ERK7 |
0.686 | 0.062 | 2 | 0.425 |
PHKG1 |
0.686 | -0.061 | -3 | 0.794 |
PKR |
0.685 | -0.063 | 1 | 0.726 |
CK1D |
0.685 | 0.095 | -3 | 0.428 |
PKCH |
0.685 | -0.040 | 2 | 0.558 |
AKT1 |
0.685 | -0.003 | -3 | 0.705 |
ULK1 |
0.685 | -0.172 | -3 | 0.760 |
AURA |
0.684 | -0.056 | -2 | 0.280 |
GSK3A |
0.684 | 0.056 | 4 | 0.346 |
GRK6 |
0.684 | -0.101 | 1 | 0.680 |
AKT3 |
0.683 | 0.018 | -3 | 0.642 |
DLK |
0.683 | -0.178 | 1 | 0.703 |
DCAMKL1 |
0.683 | -0.015 | -3 | 0.771 |
TLK2 |
0.683 | -0.073 | 1 | 0.691 |
ANKRD3 |
0.683 | -0.156 | 1 | 0.728 |
PAK2 |
0.683 | -0.087 | -2 | 0.338 |
YSK4 |
0.682 | -0.093 | 1 | 0.655 |
ACVR2B |
0.682 | -0.054 | -2 | 0.379 |
GRK3 |
0.681 | 0.036 | -2 | 0.435 |
ACVR2A |
0.681 | -0.065 | -2 | 0.357 |
MEK1 |
0.681 | -0.131 | 2 | 0.690 |
ALK2 |
0.681 | -0.019 | -2 | 0.421 |
MST3 |
0.680 | -0.007 | 2 | 0.671 |
PASK |
0.680 | 0.091 | -3 | 0.828 |
MLK4 |
0.680 | -0.078 | 2 | 0.568 |
NEK2 |
0.679 | -0.145 | 2 | 0.666 |
PERK |
0.679 | -0.062 | -2 | 0.396 |
SGK1 |
0.678 | 0.028 | -3 | 0.627 |
PKCT |
0.678 | -0.047 | 2 | 0.574 |
PLK1 |
0.677 | -0.146 | -2 | 0.329 |
CAMK1G |
0.677 | -0.027 | -3 | 0.744 |
PKCE |
0.676 | -0.006 | 2 | 0.555 |
SNRK |
0.676 | -0.099 | 2 | 0.541 |
CK1G1 |
0.676 | 0.029 | -3 | 0.486 |
IRAK4 |
0.675 | -0.087 | 1 | 0.692 |
PLK3 |
0.675 | -0.079 | 2 | 0.638 |
P70S6K |
0.675 | -0.022 | -3 | 0.706 |
GSK3B |
0.674 | -0.005 | 4 | 0.340 |
ROCK2 |
0.674 | 0.021 | -3 | 0.769 |
TAO3 |
0.674 | -0.047 | 1 | 0.694 |
MEKK2 |
0.674 | -0.059 | 2 | 0.656 |
TLK1 |
0.674 | -0.061 | -2 | 0.425 |
PKG1 |
0.674 | -0.020 | -2 | 0.308 |
PKCI |
0.674 | -0.060 | 2 | 0.590 |
MEK5 |
0.673 | -0.120 | 2 | 0.673 |
CAMK1D |
0.673 | -0.010 | -3 | 0.691 |
PDHK3_TYR |
0.672 | 0.102 | 4 | 0.749 |
SBK |
0.672 | 0.051 | -3 | 0.588 |
PAK5 |
0.672 | -0.084 | -2 | 0.256 |
WNK4 |
0.672 | -0.131 | -2 | 0.381 |
HRI |
0.672 | -0.153 | -2 | 0.373 |
CK1A2 |
0.672 | 0.033 | -3 | 0.433 |
BMPR1A |
0.672 | -0.020 | 1 | 0.577 |
BRAF |
0.672 | -0.115 | -4 | 0.656 |
MEKK1 |
0.671 | -0.103 | 1 | 0.699 |
LKB1 |
0.671 | -0.041 | -3 | 0.783 |
BUB1 |
0.671 | 0.026 | -5 | 0.731 |
GAK |
0.671 | 0.051 | 1 | 0.736 |
MAPKAPK5 |
0.671 | -0.103 | -3 | 0.716 |
SMMLCK |
0.671 | -0.064 | -3 | 0.800 |
NEK5 |
0.670 | -0.126 | 1 | 0.711 |
MEKK3 |
0.669 | -0.066 | 1 | 0.676 |
MRCKB |
0.669 | -0.017 | -3 | 0.729 |
ZAK |
0.669 | -0.119 | 1 | 0.667 |
LIMK2_TYR |
0.669 | 0.063 | -3 | 0.843 |
TNIK |
0.668 | -0.022 | 3 | 0.856 |
DMPK1 |
0.668 | 0.037 | -3 | 0.749 |
DAPK3 |
0.668 | -0.026 | -3 | 0.779 |
HGK |
0.668 | -0.044 | 3 | 0.852 |
MRCKA |
0.667 | -0.014 | -3 | 0.740 |
PLK4 |
0.667 | -0.129 | 2 | 0.482 |
TESK1_TYR |
0.666 | 0.034 | 3 | 0.850 |
DCAMKL2 |
0.666 | -0.065 | -3 | 0.789 |
PKMYT1_TYR |
0.666 | 0.078 | 3 | 0.804 |
PBK |
0.666 | 0.011 | 1 | 0.655 |
PDK1 |
0.666 | -0.044 | 1 | 0.687 |
GCK |
0.666 | -0.018 | 1 | 0.676 |
PKN1 |
0.666 | -0.031 | -3 | 0.719 |
PAK4 |
0.665 | -0.082 | -2 | 0.253 |
LOK |
0.665 | -0.080 | -2 | 0.341 |
KHS1 |
0.665 | 0.007 | 1 | 0.669 |
MEKK6 |
0.665 | -0.054 | 1 | 0.688 |
MINK |
0.665 | -0.042 | 1 | 0.672 |
CAMK1A |
0.664 | -0.003 | -3 | 0.669 |
PHKG2 |
0.664 | -0.093 | -3 | 0.772 |
TAO2 |
0.664 | -0.092 | 2 | 0.703 |
HPK1 |
0.663 | -0.038 | 1 | 0.672 |
PDHK4_TYR |
0.663 | 0.047 | 2 | 0.746 |
MAP2K4_TYR |
0.663 | -0.027 | -1 | 0.512 |
MAP3K15 |
0.663 | -0.037 | 1 | 0.662 |
CAMKK1 |
0.662 | -0.175 | -2 | 0.315 |
KHS2 |
0.662 | -0.002 | 1 | 0.687 |
SLK |
0.662 | -0.075 | -2 | 0.335 |
LRRK2 |
0.661 | -0.073 | 2 | 0.696 |
CHK2 |
0.661 | -0.015 | -3 | 0.648 |
DAPK1 |
0.661 | -0.036 | -3 | 0.765 |
IRAK1 |
0.661 | -0.170 | -1 | 0.396 |
MAP2K6_TYR |
0.660 | -0.011 | -1 | 0.510 |
HASPIN |
0.660 | -0.011 | -1 | 0.383 |
DRAK1 |
0.660 | -0.144 | 1 | 0.616 |
NEK11 |
0.659 | -0.117 | 1 | 0.683 |
NEK4 |
0.659 | -0.133 | 1 | 0.681 |
TTBK1 |
0.659 | -0.090 | 2 | 0.485 |
EEF2K |
0.659 | -0.047 | 3 | 0.831 |
ROCK1 |
0.659 | -0.014 | -3 | 0.739 |
NEK8 |
0.659 | -0.147 | 2 | 0.664 |
CRIK |
0.658 | 0.026 | -3 | 0.703 |
MAP2K7_TYR |
0.658 | -0.091 | 2 | 0.718 |
PLK2 |
0.658 | -0.001 | -3 | 0.838 |
MST2 |
0.658 | -0.090 | 1 | 0.669 |
BMPR2_TYR |
0.658 | -0.035 | -1 | 0.469 |
CAMKK2 |
0.658 | -0.171 | -2 | 0.307 |
PDHK1_TYR |
0.657 | -0.035 | -1 | 0.501 |
TAK1 |
0.656 | -0.089 | 1 | 0.696 |
CK2A2 |
0.655 | -0.030 | 1 | 0.541 |
VRK1 |
0.655 | -0.105 | 2 | 0.703 |
LIMK1_TYR |
0.655 | -0.062 | 2 | 0.722 |
NEK1 |
0.653 | -0.135 | 1 | 0.689 |
PINK1_TYR |
0.653 | -0.145 | 1 | 0.742 |
FGR |
0.652 | 0.066 | 1 | 0.695 |
RET |
0.652 | -0.092 | 1 | 0.712 |
ROS1 |
0.651 | -0.013 | 3 | 0.725 |
CK1A |
0.650 | 0.053 | -3 | 0.343 |
YSK1 |
0.650 | -0.105 | 2 | 0.662 |
TYK2 |
0.650 | -0.090 | 1 | 0.700 |
TNNI3K_TYR |
0.649 | 0.000 | 1 | 0.697 |
MST1 |
0.649 | -0.100 | 1 | 0.664 |
TTK |
0.647 | -0.037 | -2 | 0.374 |
CSF1R |
0.647 | -0.042 | 3 | 0.727 |
NEK10_TYR |
0.647 | -0.055 | 1 | 0.658 |
JAK2 |
0.647 | -0.083 | 1 | 0.707 |
MST1R |
0.647 | -0.099 | 3 | 0.753 |
YES1 |
0.646 | -0.019 | -1 | 0.519 |
TYRO3 |
0.646 | -0.097 | 3 | 0.754 |
LCK |
0.646 | -0.004 | -1 | 0.478 |
STK33 |
0.645 | -0.132 | 2 | 0.455 |
ABL2 |
0.645 | -0.061 | -1 | 0.439 |
EPHA6 |
0.645 | -0.071 | -1 | 0.445 |
CK2A1 |
0.645 | -0.039 | 1 | 0.525 |
NEK3 |
0.645 | -0.151 | 1 | 0.664 |
MEK2 |
0.644 | -0.199 | 2 | 0.671 |
OSR1 |
0.644 | -0.075 | 2 | 0.646 |
JAK1 |
0.643 | -0.017 | 1 | 0.636 |
TXK |
0.643 | -0.028 | 1 | 0.645 |
MYO3B |
0.643 | -0.081 | 2 | 0.686 |
ABL1 |
0.642 | -0.068 | -1 | 0.438 |
BIKE |
0.642 | -0.018 | 1 | 0.637 |
DDR1 |
0.641 | -0.119 | 4 | 0.663 |
BLK |
0.641 | 0.003 | -1 | 0.464 |
INSRR |
0.640 | -0.054 | 3 | 0.692 |
TNK1 |
0.640 | -0.073 | 3 | 0.730 |
JAK3 |
0.640 | -0.106 | 1 | 0.684 |
HCK |
0.640 | -0.066 | -1 | 0.471 |
MYO3A |
0.639 | -0.086 | 1 | 0.682 |
FER |
0.639 | -0.087 | 1 | 0.693 |
AAK1 |
0.639 | 0.038 | 1 | 0.562 |
FGFR2 |
0.638 | -0.075 | 3 | 0.730 |
EPHB4 |
0.637 | -0.134 | -1 | 0.436 |
ASK1 |
0.637 | -0.082 | 1 | 0.655 |
KIT |
0.637 | -0.079 | 3 | 0.724 |
RIPK2 |
0.637 | -0.206 | 1 | 0.617 |
FYN |
0.636 | 0.014 | -1 | 0.484 |
KDR |
0.636 | -0.078 | 3 | 0.695 |
TNK2 |
0.636 | -0.080 | 3 | 0.678 |
WEE1_TYR |
0.635 | -0.072 | -1 | 0.419 |
FGFR1 |
0.635 | -0.072 | 3 | 0.703 |
FLT3 |
0.635 | -0.105 | 3 | 0.742 |
SRMS |
0.634 | -0.101 | 1 | 0.663 |
MET |
0.634 | -0.044 | 3 | 0.714 |
PDGFRB |
0.633 | -0.148 | 3 | 0.748 |
TAO1 |
0.632 | -0.124 | 1 | 0.629 |
ALPHAK3 |
0.632 | -0.047 | -1 | 0.419 |
YANK3 |
0.632 | -0.043 | 2 | 0.295 |
ITK |
0.632 | -0.121 | -1 | 0.435 |
BMX |
0.631 | -0.085 | -1 | 0.386 |
PTK6 |
0.630 | -0.134 | -1 | 0.424 |
TEK |
0.630 | -0.102 | 3 | 0.668 |
ALK |
0.629 | -0.096 | 3 | 0.642 |
AXL |
0.628 | -0.147 | 3 | 0.713 |
FGFR3 |
0.627 | -0.072 | 3 | 0.703 |
PDGFRA |
0.627 | -0.159 | 3 | 0.743 |
DDR2 |
0.627 | -0.052 | 3 | 0.661 |
TEC |
0.627 | -0.107 | -1 | 0.396 |
MERTK |
0.627 | -0.128 | 3 | 0.709 |
SRC |
0.626 | -0.017 | -1 | 0.481 |
BTK |
0.626 | -0.156 | -1 | 0.424 |
EPHA4 |
0.626 | -0.117 | 2 | 0.637 |
LYN |
0.625 | -0.070 | 3 | 0.649 |
FLT1 |
0.624 | -0.118 | -1 | 0.424 |
MATK |
0.624 | -0.077 | -1 | 0.384 |
INSR |
0.624 | -0.101 | 3 | 0.675 |
LTK |
0.624 | -0.131 | 3 | 0.665 |
SYK |
0.623 | 0.032 | -1 | 0.402 |
ERBB2 |
0.623 | -0.096 | 1 | 0.642 |
EPHB1 |
0.622 | -0.190 | 1 | 0.653 |
EPHB2 |
0.622 | -0.152 | -1 | 0.415 |
NTRK3 |
0.621 | -0.105 | -1 | 0.450 |
STLK3 |
0.621 | -0.149 | 1 | 0.640 |
EPHB3 |
0.621 | -0.179 | -1 | 0.423 |
EGFR |
0.621 | -0.055 | 1 | 0.566 |
FRK |
0.619 | -0.112 | -1 | 0.449 |
NTRK1 |
0.619 | -0.171 | -1 | 0.465 |
NTRK2 |
0.618 | -0.173 | 3 | 0.692 |
ZAP70 |
0.618 | 0.036 | -1 | 0.360 |
CK1G3 |
0.618 | 0.010 | -3 | 0.300 |
FGFR4 |
0.617 | -0.081 | -1 | 0.410 |
FLT4 |
0.616 | -0.163 | 3 | 0.694 |
PTK2B |
0.615 | -0.102 | -1 | 0.441 |
PTK2 |
0.614 | -0.042 | -1 | 0.398 |
EPHA1 |
0.614 | -0.171 | 3 | 0.694 |
EPHA3 |
0.612 | -0.168 | 2 | 0.609 |
CK1G2 |
0.611 | 0.047 | -3 | 0.398 |
EPHA7 |
0.611 | -0.161 | 2 | 0.634 |
CSK |
0.610 | -0.148 | 2 | 0.639 |
ERBB4 |
0.607 | -0.036 | 1 | 0.564 |
EPHA8 |
0.607 | -0.125 | -1 | 0.396 |
YANK2 |
0.607 | -0.053 | 2 | 0.311 |
IGF1R |
0.605 | -0.110 | 3 | 0.604 |
EPHA5 |
0.605 | -0.154 | 2 | 0.622 |
MUSK |
0.604 | -0.132 | 1 | 0.558 |
EPHA2 |
0.596 | -0.152 | -1 | 0.365 |
FES |
0.591 | -0.125 | -1 | 0.384 |