Motif 4 (n=202)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J1V8 | PPAN-P2RY11 | S238 | ochoa | HCG2039996 (PPAN-P2RY11 readthrough) | None |
| A0A0U1RQV5 | None | S26 | ochoa | Eukaryotic translation initiation factor 6 | None |
| O00165 | HAX1 | S210 | psp | HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1) | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. {ECO:0000269|PubMed:15339924, ECO:0000269|PubMed:16857965, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:18319618, ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:26997484, ECO:0000269|PubMed:9058808}. |
| O15217 | GSTA4 | S189 | psp | Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}. |
| O43683 | BUB1 | S176 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60684 | KPNA6 | S459 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O75143 | ATG13 | S477 | ochoa | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O75396 | SEC22B | S177 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O75943 | RAD17 | S86 | ochoa | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}. |
| O94776 | MTA2 | S440 | ochoa | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| O94804 | STK10 | S516 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94885 | SASH1 | S701 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95069 | KCNK2 | S36 | ochoa | Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK1) (Two pore potassium channel TPKC1) (K2P2.1) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Reversibly converts between a voltage-insensitive K(+) 'leak' channel and a voltage-dependent outward rectifying K(+) channel in a phosphorylation-dependent manner (By similarity) (PubMed:10321245, PubMed:10784345, PubMed:11319556, PubMed:23169818, PubMed:30573346, PubMed:38605031). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). In trigeminal ganglia sensory neurons, the heterodimer of KCNK2/TREK-1 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (By similarity). In hippocampal astrocytes, the heterodimer of KCNK2/TREK-1 and KCNK1/TWIK-1 allows passive K(+) conductance under basal conditions, but changes ion selectivity and becomes permeable to L-glutamate and Cl(-) ions upon binding to G-protein subunit GNG4 in stimulated astrocytes. Mediates rapid L-glutamate release in response to activation of G-protein-coupled receptors, such as F2R and CNR1 (By similarity). In hippocampal pyramidal neurons, the homodimer of KCNK2/TREK-1 contributes to gamma-aminobutyric acid (GABA) B-induced slow inhibitory postsynaptic potential. Associates with AKAP5 and Gs-protein-coupled receptor B2AR at postsynaptic dense bodies and converts to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity). {ECO:0000250|UniProtKB:P97438, ECO:0000250|UniProtKB:Q920B6, ECO:0000269|PubMed:10321245, ECO:0000269|PubMed:10784345, ECO:0000269|PubMed:11319556, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:30573346, ECO:0000269|PubMed:38605031}.; FUNCTION: [Isoform 4]: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. {ECO:0000250|UniProtKB:Q920B6}. |
| O95249 | GOSR1 | S41 | ochoa | Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) | Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}. |
| O95271 | TNKS | S987 | psp | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}. |
| O95613 | PCNT | S2044 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95865 | DDAH2 | S253 | psp | Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) | Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}. |
| P00374 | DHFR | S168 | psp | Dihydrofolate reductase (EC 1.5.1.3) | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}. |
| P04350 | TUBB4A | S95 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04920 | SLC4A2 | S461 | ochoa | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
| P05181 | CYP2E1 | S74 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
| P06241 | FYN | S188 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P07437 | TUBB | S95 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07947 | YES1 | S197 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P07948 | LYN | S168 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P08195 | SLC3A2 | S406 | psp | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P08240 | SRPRA | S46 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P09211 | GSTP1 | S185 | psp | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| P09488 | GSTM1 | S27 | ochoa | Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16548513, ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:9084911}. |
| P09769 | FGR | S183 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P09874 | PARP1 | S874 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0CG47 | UBB | S57 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | S57 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P0DPH7 | TUBA3C | S379 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S379 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P15311 | EZR | S112 | ochoa | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P15498 | VAV1 | S113 | ochoa | Proto-oncogene vav | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| P16066 | NPR1 | S534 | psp | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). {ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:36016499, ECO:0000269|PubMed:39543315}. |
| P16070 | CD44 | S672 | psp | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P16615 | ATP2A2 | S473 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P20290 | BTF3 | S173 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P21731 | TBXA2R | S324 | psp | Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) | Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 1]: Activates adenylyl cyclase. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 2]: Inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}. |
| P25705 | ATP5F1A | S413 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P26641 | EEF1G | S33 | ochoa | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
| P26641 | EEF1G | S304 | ochoa | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
| P28161 | GSTM2 | S27 | ochoa | Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:21046276}. |
| P29350 | PTPN6 | S42 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P33981 | TTK | S80 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P36952 | SERPINB5 | S240 | psp | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| P40926 | MDH2 | S69 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P41235 | HNF4A | S303 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P42575 | CASP2 | S139 | psp | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}. |
| P46779 | RPL28 | S91 | ochoa | Large ribosomal subunit protein eL28 (60S ribosomal protein L28) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P46934 | NEDD4 | S467 | ochoa | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:19920177, PubMed:21399620, PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}. |
| P47897 | QARS1 | S70 | ochoa | Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) | Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). {ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}. |
| P48637 | GSS | S181 | ochoa | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}. |
| P49327 | FASN | S2198 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49327 | FASN | S2417 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P50336 | PPOX | S213 | ochoa | Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4) | Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. {ECO:0000269|PubMed:21048046, ECO:0000269|PubMed:23467411, ECO:0000269|PubMed:7713909}. |
| P51955 | NEK2 | S304 | ochoa | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P54132 | BLM | S336 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P55211 | CASP9 | S99 | psp | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}. |
| P56537 | EIF6 | S174 | ochoa|psp | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}. |
| P62491 | RAB11A | S42 | ochoa | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| P62979 | RPS27A | S57 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | S57 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P68363 | TUBA1B | S379 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S379 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68371 | TUBB4B | S95 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68400 | CSNK2A1 | S287 | ochoa | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391, PubMed:22017874, PubMed:22406621, PubMed:24962073, PubMed:30898438, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387551, PubMed:19387552). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, MRE11, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:28512243, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:16193064, PubMed:22184066). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (PubMed:22184066). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (PubMed:30765518, PubMed:31439799). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| P68871 | HBB | S90 | ochoa | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| P78559 | MAP1A | Y177 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q02535 | ID3 | S65 | psp | DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3) | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}. |
| Q03013 | GSTM4 | S27 | ochoa | Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). {ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:8203914, ECO:0000269|PubMed:8373352}. |
| Q03252 | LMNB2 | S292 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q06587 | RING1 | S139 | ochoa | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}. |
| Q08050 | FOXM1 | S732 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q0P6D2 | DIPK1C | S51 | psp | Divergent protein kinase domain 1C (Protein FAM69C) | None |
| Q13085 | ACACA | S50 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13191 | CBLB | S761 | ochoa | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}. |
| Q13285 | NR5A1 | S430 | psp | Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) | Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250|UniProtKB:P33242, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:27378692, ECO:0000269|PubMed:28459839}. |
| Q13459 | MYO9B | S1045 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13469 | NFATC2 | S79 | psp | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13495 | MAMLD1 | S218 | ochoa | Mastermind-like domain-containing protein 1 (F18) (Protein CG1) | Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}. |
| Q13568 | IRF5 | Y335 | psp | Interferon regulatory factor 5 (IRF-5) | Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}. |
| Q13885 | TUBB2A | S95 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14202 | ZMYM3 | S1045 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14204 | DYNC1H1 | S70 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14318 | FKBP8 | S323 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}. |
| Q14571 | ITPR2 | S1871 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}. |
| Q14814 | MEF2D | S275 | psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q15306 | IRF4 | Y325 | psp | Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5) | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. {ECO:0000269|PubMed:29537367, ECO:0000269|PubMed:36662884, ECO:0000269|PubMed:36917008}. |
| Q15327 | ANKRD1 | S213 | ochoa | Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein) | May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}. |
| Q15907 | RAB11B | S42 | ochoa | Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970, PubMed:26032412). The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). {ECO:0000269|PubMed:14627637, ECO:0000269|PubMed:19029296, ECO:0000269|PubMed:19244346, ECO:0000269|PubMed:20717956, ECO:0000269|PubMed:21248079, ECO:0000269|PubMed:22129970, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173}. |
| Q16513 | PKN2 | S29 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16513 | PKN2 | S163 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q2TAL5 | SMTNL2 | S129 | ochoa | Smoothelin-like protein 2 | None |
| Q5JVF3 | PCID2 | S24 | ochoa | PCI domain-containing protein 2 (CSN12-like protein) | Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity). {ECO:0000250|UniProtKB:Q8BFV2, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180, ECO:0000305|PubMed:23591820}. |
| Q5T035 | FAM120A2P | S68 | ochoa | Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) | None |
| Q5T5Y3 | CAMSAP1 | S583 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TGY3 | AHDC1 | S499 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VT06 | CEP350 | S930 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VYK3 | ECPAS | S1077 | ochoa | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}. |
| Q68DA7 | FMN1 | S842 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
| Q6GYQ0 | RALGAPA1 | S691 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6ISB3 | GRHL2 | S81 | ochoa | Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3) | Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456, PubMed:29309642). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). {ECO:0000250|UniProtKB:Q8K5C0, ECO:0000269|PubMed:19015635, ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:23254293, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29309642, ECO:0000305|PubMed:12175488}. |
| Q6P2E9 | EDC4 | S583 | ochoa|psp | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6UXT9 | ABHD15 | S429 | ochoa | Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) | May regulate adipocyte lipolysis and liver lipid accumulation. {ECO:0000250|UniProtKB:Q5F2F2}. |
| Q6WKZ4 | RAB11FIP1 | S300 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6WKZ4 | RAB11FIP1 | S313 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q70CQ2 | USP34 | S490 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q71U36 | TUBA1A | S379 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7KZI7 | MARK2 | S477 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z2W4 | ZC3HAV1 | S101 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z6Z7 | HUWE1 | S3135 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86V15 | CASZ1 | S739 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86XK3 | SFR1 | S65 | ochoa | Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) | Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}. |
| Q8IUD6 | RNF135 | S159 | ochoa | E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135) | E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531). {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:21147464, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531, ECO:0000305|PubMed:31006531}. |
| Q8NBJ4 | GOLM1 | S204 | ochoa | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | Unknown. Cellular response protein to viral infection. |
| Q8ND76 | CCNY | S295 | psp | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NEV1 | CSNK2A3 | S287 | ochoa | Casein kinase II subunit alpha 3 (CK II alpha 3) (EC 2.7.11.1) (Casein kinase II alpha 1 polypeptide pseudogene) | Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. {ECO:0000269|PubMed:20625391}. |
| Q8NEZ4 | KMT2C | S1387 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8WUI4 | HDAC7 | S464 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q92499 | DDX1 | S377 | psp | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q92613 | JADE3 | S650 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92614 | MYO18A | S1640 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92966 | SNAPC3 | S69 | ochoa | snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}. |
| Q96E39 | RBMXL1 | S184 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96GE4 | CEP95 | S451 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96N67 | DOCK7 | S190 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96P20 | NLRP3 | S806 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q96P20 | NLRP3 | S975 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q96PY5 | FMNL2 | S406 | ochoa | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96QD5 | DEPDC7 | S486 | ochoa | DEP domain-containing protein 7 (Protein TR2/D15) | None |
| Q96RG2 | PASK | S65 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q99081 | TCF12 | S147 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99541 | PLIN2 | S224 | ochoa | Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. {ECO:0000269|PubMed:34077757}. |
| Q99614 | TTC1 | S265 | ochoa | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q9BQS8 | FYCO1 | S1165 | ochoa | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| Q9BSJ8 | ESYT1 | S1086 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BSM1 | PCGF1 | S146 | ochoa | Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) | Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479). {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:16943429, ECO:0000269|PubMed:17088287, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:26687479}. |
| Q9BV38 | WDR18 | S371 | ochoa | WD repeat-containing protein 18 | Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). May play a role during development (By similarity). {ECO:0000250|UniProtKB:Q68EI0, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q9BV86 | NTMT1 | S63 | ochoa | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed] | Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352, ECO:0000269|PubMed:26543159}. |
| Q9BVA1 | TUBB2B | S95 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BX66 | SORBS1 | S328 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9GZY0 | NXF2 | S289 | ochoa | Nuclear RNA export factor 2 (Cancer/testis antigen 39) (CT39) (TAP-like protein 2) (TAPL-2) | Involved in the export of mRNA from the nucleus to the cytoplasm. |
| Q9H1B4 | NXF5 | S178 | ochoa | Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1) | Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons. |
| Q9H244 | P2RY12 | S323 | ochoa | P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) | Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}. |
| Q9H2S1 | KCNN2 | S135 | psp | Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) | Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10991935, PubMed:33242881, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:10991935). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:10991935). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions. There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation. Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner. Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (By similarity). Plays a role in the repolarization phase of cardiac action potential (PubMed:13679367). {ECO:0000250|UniProtKB:P70604, ECO:0000269|PubMed:10991935, ECO:0000269|PubMed:13679367, ECO:0000269|PubMed:33242881, ECO:0000269|PubMed:9287325}. |
| Q9H4B7 | TUBB1 | S95 | ochoa | Tubulin beta-1 chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9H799 | CPLANE1 | S154 | ochoa | Ciliogenesis and planar polarity effector 1 (Protein JBTS17) | Involved in ciliogenesis (PubMed:25877302, PubMed:35582950). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000269|PubMed:35582950, ECO:0000305|PubMed:25877302}. |
| Q9HC77 | CPAP | S589 | psp | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HCE1 | MOV10 | S969 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
| Q9NQ55 | PPAN | S238 | ochoa | Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) | May have a role in cell growth. |
| Q9NQS7 | INCENP | S510 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQW6 | ANLN | S362 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRA8 | EIF4ENIF1 | S541 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NY65 | TUBA8 | S379 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NYA4 | MTMR4 | S616 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). {ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:20061380, ECO:0000269|PubMed:20736309, ECO:0000269|PubMed:23150675, ECO:0000269|PubMed:25659891, ECO:0000269|PubMed:27625994, ECO:0000269|PubMed:29962048, ECO:0000269|PubMed:30944173, ECO:0000269|PubMed:31543504}. |
| Q9NYP3 | DONSON | S542 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
| Q9NZN5 | ARHGEF12 | S1273 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P1Y5 | CAMSAP3 | S1051 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P219 | CCDC88C | S446 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9ULT0 | TTC7A | S647 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9UNE7 | STUB1 | S137 | ochoa | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) | E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (By similarity). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). Plays a role in the degradation of TP53 (PubMed:26634371). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity). {ECO:0000250|UniProtKB:A6HD62, ECO:0000250|UniProtKB:Q9WUD1, ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30980393}. |
| Q9UP83 | COG5 | S197 | ochoa | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | Required for normal Golgi function. {ECO:0000250|UniProtKB:Q9VJD3}. |
| Q9UPM8 | AP4E1 | S665 | ochoa | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UPN4 | CEP131 | S525 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UQ13 | SHOC2 | S297 | psp | Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog) | Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (PubMed:10783161, PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Acts as a scaffolding protein in the SMP complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:10783161, PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:10783161, ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:25137548, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| Q9UQ13 | SHOC2 | T507 | psp | Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog) | Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (PubMed:10783161, PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Acts as a scaffolding protein in the SMP complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:10783161, PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:10783161, ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:25137548, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| Q9Y2L1 | DIS3 | S215 | ochoa | Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20531386}. |
| Q9Y446 | PKP3 | S323 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y490 | TLN1 | T1142 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B4 | RAD54L2 | S1234 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y6Q9 | NCOA3 | S1048 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| P61221 | ABCE1 | S218 | Sugiyama | ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}. |
| O14733 | MAP2K7 | S89 | Sugiyama | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O14965 | AURKA | S278 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| O60566 | BUB1B | S25 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q6UVK1 | CSPG4 | S1857 | Sugiyama | Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan) | Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. {ECO:0000269|PubMed:10587647, ECO:0000269|PubMed:11278606, ECO:0000269|PubMed:15210734}. |
| P41091 | EIF2S3 | S412 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| Q2VIR3 | EIF2S3B | S412 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}. |
| P00519 | ABL1 | S750 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P12814 | ACTN1 | Y511 | Sugiyama | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| Q9UHX1 | PUF60 | S232 | Sugiyama | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| P13674 | P4HA1 | S387 | Sugiyama | Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}. |
| Q96SB3 | PPP1R9B | S94 | ELM|iPTMNet|EPSD | Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin) | Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration. {ECO:0000250, ECO:0000269|PubMed:19151759}. |
| P14868 | DARS1 | S369 | Sugiyama | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}. |
| P43405 | SYK | S54 | Sugiyama | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| O15355 | PPM1G | S349 | Sugiyama | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| P54760 | EPHB4 | S735 | Sugiyama | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P06744 | GPI | S359 | Sugiyama | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}. |
| Q07020 | RPL18 | S62 | Sugiyama | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q13882 | PTK6 | S117 | Sugiyama | Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) | Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation (PubMed:20554524). Also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. {ECO:0000269|PubMed:20554524}.; FUNCTION: [Isoform 2]: Inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins. |
| P29590 | PML | S366 | Sugiyama | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| Q5S007 | LRRK2 | S1536 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q9Y316 | MEMO1 | S91 | Sugiyama | Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1) | May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}. |
| Q8IY84 | NIM1K | S119 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| Q9UPQ9 | TNRC6B | S1086 | Sugiyama | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q04637 | EIF4G1 | S1134 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q9H0H5 | RACGAP1 | S410 | ELM|iPTMNet|EPSD | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q14444 | CAPRIN1 | S120 | Sugiyama | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9646399 | Aggrephagy | 1.110223e-16 | 15.955 |
| R-HSA-9663891 | Selective autophagy | 1.110223e-16 | 15.955 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.553513e-15 | 14.593 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 4.329870e-15 | 14.364 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.853273e-14 | 13.545 |
| R-HSA-69275 | G2/M Transition | 2.875478e-14 | 13.541 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.530509e-14 | 13.452 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.530509e-14 | 13.452 |
| R-HSA-9612973 | Autophagy | 7.893686e-14 | 13.103 |
| R-HSA-1632852 | Macroautophagy | 1.157963e-13 | 12.936 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.766987e-13 | 12.424 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.075629e-13 | 12.390 |
| R-HSA-68877 | Mitotic Prometaphase | 4.737322e-13 | 12.324 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.704326e-13 | 12.244 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.633471e-12 | 11.787 |
| R-HSA-913531 | Interferon Signaling | 1.718736e-12 | 11.765 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.976863e-12 | 11.704 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.617129e-12 | 11.582 |
| R-HSA-190861 | Gap junction assembly | 3.506861e-12 | 11.455 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.081358e-12 | 11.216 |
| R-HSA-437239 | Recycling pathway of L1 | 6.081358e-12 | 11.216 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.149714e-11 | 10.939 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.392930e-11 | 10.621 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.506662e-11 | 10.601 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.673717e-11 | 10.573 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.190592e-11 | 10.496 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.202361e-11 | 10.377 |
| R-HSA-190828 | Gap junction trafficking | 5.239320e-11 | 10.281 |
| R-HSA-1640170 | Cell Cycle | 5.522416e-11 | 10.258 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.120093e-11 | 10.213 |
| R-HSA-983189 | Kinesins | 8.049883e-11 | 10.094 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.474091e-10 | 9.831 |
| R-HSA-68882 | Mitotic Anaphase | 1.848228e-10 | 9.733 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.972593e-10 | 9.705 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.992798e-10 | 9.701 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.146349e-10 | 9.668 |
| R-HSA-68886 | M Phase | 2.276745e-10 | 9.643 |
| R-HSA-422475 | Axon guidance | 3.011505e-10 | 9.521 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.068480e-10 | 9.513 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.874617e-10 | 9.312 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.567329e-10 | 9.183 |
| R-HSA-5617833 | Cilium Assembly | 9.897204e-10 | 9.004 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.102958e-09 | 8.957 |
| R-HSA-9675108 | Nervous system development | 1.397047e-09 | 8.855 |
| R-HSA-9833482 | PKR-mediated signaling | 1.755478e-09 | 8.756 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.912791e-09 | 8.718 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.029541e-09 | 8.519 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 8.271218e-09 | 8.082 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.874276e-09 | 8.052 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.310436e-08 | 7.883 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.471364e-08 | 7.832 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.496871e-08 | 7.825 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.781683e-08 | 7.749 |
| R-HSA-373760 | L1CAM interactions | 2.141633e-08 | 7.669 |
| R-HSA-5620924 | Intraflagellar transport | 2.371363e-08 | 7.625 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.984637e-08 | 7.525 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.060912e-08 | 7.391 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.545895e-08 | 7.342 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.545895e-08 | 7.342 |
| R-HSA-1280218 | Adaptive Immune System | 5.874270e-08 | 7.231 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.338004e-08 | 7.134 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.330685e-08 | 7.079 |
| R-HSA-391251 | Protein folding | 8.681022e-08 | 7.061 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 9.181482e-08 | 7.037 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.706313e-08 | 7.013 |
| R-HSA-109582 | Hemostasis | 1.072116e-07 | 6.970 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.793781e-07 | 6.746 |
| R-HSA-6807070 | PTEN Regulation | 1.936489e-07 | 6.713 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.083942e-07 | 6.681 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.083942e-07 | 6.681 |
| R-HSA-2262752 | Cellular responses to stress | 2.355299e-07 | 6.628 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.559607e-07 | 6.592 |
| R-HSA-1266738 | Developmental Biology | 3.084193e-07 | 6.511 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.409733e-07 | 6.467 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.467546e-07 | 6.350 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.248570e-07 | 6.280 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.812835e-07 | 6.167 |
| R-HSA-380287 | Centrosome maturation | 8.466404e-07 | 6.072 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 9.534895e-07 | 6.021 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 9.534895e-07 | 6.021 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.409926e-06 | 5.851 |
| R-HSA-162582 | Signal Transduction | 1.409701e-06 | 5.851 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.484722e-06 | 5.828 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 2.144036e-06 | 5.669 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.040812e-06 | 5.517 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.040812e-06 | 5.517 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 3.067181e-06 | 5.513 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.769105e-06 | 5.424 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.485220e-06 | 5.458 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.157985e-06 | 5.381 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 4.667049e-06 | 5.331 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 4.967063e-06 | 5.304 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.708653e-06 | 5.243 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.827032e-06 | 5.235 |
| R-HSA-9609690 | HCMV Early Events | 7.802162e-06 | 5.108 |
| R-HSA-9694493 | Maturation of protein E | 8.372255e-06 | 5.077 |
| R-HSA-9683683 | Maturation of protein E | 8.372255e-06 | 5.077 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.678906e-06 | 5.014 |
| R-HSA-156590 | Glutathione conjugation | 1.267913e-05 | 4.897 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.568818e-05 | 4.804 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.683366e-05 | 4.774 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.900895e-05 | 4.721 |
| R-HSA-69236 | G1 Phase | 1.903687e-05 | 4.720 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.903687e-05 | 4.720 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.999900e-05 | 4.699 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.001292e-05 | 4.699 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.084995e-05 | 4.681 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.242219e-05 | 4.649 |
| R-HSA-168256 | Immune System | 2.459245e-05 | 4.609 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 2.886642e-05 | 4.540 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 2.886642e-05 | 4.540 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 2.886642e-05 | 4.540 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.153016e-05 | 4.501 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.393399e-05 | 4.469 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 4.039540e-05 | 4.394 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.779725e-05 | 4.423 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.788111e-05 | 4.320 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.463090e-05 | 4.263 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 5.497530e-05 | 4.260 |
| R-HSA-5689877 | Josephin domain DUBs | 5.497530e-05 | 4.260 |
| R-HSA-9664873 | Pexophagy | 5.497530e-05 | 4.260 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 5.835931e-05 | 4.234 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 7.306275e-05 | 4.136 |
| R-HSA-210990 | PECAM1 interactions | 7.306275e-05 | 4.136 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 7.306275e-05 | 4.136 |
| R-HSA-9609646 | HCMV Infection | 9.035113e-05 | 4.044 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 9.513517e-05 | 4.022 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 9.513517e-05 | 4.022 |
| R-HSA-209560 | NF-kB is activated and signals survival | 9.513517e-05 | 4.022 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.012584e-04 | 3.995 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.012584e-04 | 3.995 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.012584e-04 | 3.995 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.012584e-04 | 3.995 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.012584e-04 | 3.995 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.216888e-04 | 3.915 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.133872e-04 | 3.945 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.216888e-04 | 3.915 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.216888e-04 | 3.915 |
| R-HSA-199991 | Membrane Trafficking | 1.178344e-04 | 3.929 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.216888e-04 | 3.915 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.216888e-04 | 3.915 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.216888e-04 | 3.915 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.161584e-04 | 3.935 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.161584e-04 | 3.935 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.216888e-04 | 3.915 |
| R-HSA-9607240 | FLT3 Signaling | 1.127997e-04 | 3.948 |
| R-HSA-8848021 | Signaling by PTK6 | 1.317917e-04 | 3.880 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.317917e-04 | 3.880 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.336934e-04 | 3.874 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.529897e-04 | 3.815 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.532370e-04 | 3.815 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.903082e-04 | 3.721 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.903082e-04 | 3.721 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.837123e-04 | 3.736 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.903082e-04 | 3.721 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.903082e-04 | 3.721 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.903082e-04 | 3.721 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.967010e-04 | 3.706 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.334447e-04 | 3.632 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.334447e-04 | 3.632 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.334447e-04 | 3.632 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.334447e-04 | 3.632 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.334447e-04 | 3.632 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.334447e-04 | 3.632 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.334447e-04 | 3.632 |
| R-HSA-5693538 | Homology Directed Repair | 2.374478e-04 | 3.624 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.832007e-04 | 3.548 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.528582e-04 | 3.597 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.971861e-04 | 3.527 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.510420e-04 | 3.600 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.510420e-04 | 3.600 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.971861e-04 | 3.527 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.623658e-04 | 3.581 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.914623e-04 | 3.535 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.570144e-04 | 3.590 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.046529e-04 | 3.516 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.865060e-04 | 3.543 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.832007e-04 | 3.548 |
| R-HSA-9708530 | Regulation of BACH1 activity | 2.832007e-04 | 3.548 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.832007e-04 | 3.548 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.920770e-04 | 3.535 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.369526e-04 | 3.472 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.401407e-04 | 3.468 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.401407e-04 | 3.468 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.401407e-04 | 3.468 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 3.401407e-04 | 3.468 |
| R-HSA-1980143 | Signaling by NOTCH1 | 3.617398e-04 | 3.442 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.772238e-04 | 3.423 |
| R-HSA-9824446 | Viral Infection Pathways | 3.986248e-04 | 3.399 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.030275e-04 | 3.395 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 4.048386e-04 | 3.393 |
| R-HSA-3229121 | Glycogen storage diseases | 4.048386e-04 | 3.393 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.100296e-04 | 3.387 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.228700e-04 | 3.374 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.271199e-04 | 3.369 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.725621e-04 | 3.326 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.725621e-04 | 3.326 |
| R-HSA-5205647 | Mitophagy | 4.725621e-04 | 3.326 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.768915e-04 | 3.322 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 4.778755e-04 | 3.321 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.084920e-04 | 3.294 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.175695e-04 | 3.286 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.175695e-04 | 3.286 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.265271e-04 | 3.279 |
| R-HSA-110320 | Translesion Synthesis by POLH | 5.598390e-04 | 3.252 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 5.598390e-04 | 3.252 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 5.598390e-04 | 3.252 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.849962e-04 | 3.233 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.849962e-04 | 3.233 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.849962e-04 | 3.233 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.055607e-04 | 3.218 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.055607e-04 | 3.218 |
| R-HSA-4641257 | Degradation of AXIN | 6.482053e-04 | 3.188 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 6.482053e-04 | 3.188 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 8.652326e-04 | 3.063 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.455399e-04 | 3.128 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 8.276919e-04 | 3.082 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 7.898070e-04 | 3.102 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.138729e-04 | 3.146 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 7.163943e-04 | 3.145 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 8.652326e-04 | 3.063 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.108933e-04 | 3.091 |
| R-HSA-6807004 | Negative regulation of MET activity | 6.513217e-04 | 3.186 |
| R-HSA-175474 | Assembly Of The HIV Virion | 8.652326e-04 | 3.063 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 8.652326e-04 | 3.063 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.355683e-04 | 3.133 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 7.529199e-04 | 3.123 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.571216e-04 | 3.182 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 7.529199e-04 | 3.123 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 7.529199e-04 | 3.123 |
| R-HSA-3322077 | Glycogen synthesis | 6.513217e-04 | 3.186 |
| R-HSA-1643685 | Disease | 8.401695e-04 | 3.076 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 7.529199e-04 | 3.123 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 7.529199e-04 | 3.123 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 8.686909e-04 | 3.061 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.769976e-04 | 3.057 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.769976e-04 | 3.057 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 9.532970e-04 | 3.021 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 9.888604e-04 | 3.005 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 9.983998e-04 | 3.001 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.009101e-03 | 2.996 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.009101e-03 | 2.996 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.056801e-03 | 2.976 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.084883e-03 | 2.965 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.101444e-03 | 2.958 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.117853e-03 | 2.952 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.244007e-03 | 2.905 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.272464e-03 | 2.895 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.354074e-03 | 2.868 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.390264e-03 | 2.857 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.407231e-03 | 2.852 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.421631e-03 | 2.847 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.464263e-03 | 2.834 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.471163e-03 | 2.832 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.471163e-03 | 2.832 |
| R-HSA-5663205 | Infectious disease | 1.568913e-03 | 2.804 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.595542e-03 | 2.797 |
| R-HSA-525793 | Myogenesis | 1.608528e-03 | 2.794 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.608528e-03 | 2.794 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 1.608528e-03 | 2.794 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.608528e-03 | 2.794 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.613729e-03 | 2.792 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.711974e-03 | 2.767 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.797722e-03 | 2.745 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 1.797722e-03 | 2.745 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.797722e-03 | 2.745 |
| R-HSA-877300 | Interferon gamma signaling | 1.846738e-03 | 2.734 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.001811e-03 | 2.699 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.001811e-03 | 2.699 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.009023e-03 | 2.697 |
| R-HSA-9766229 | Degradation of CDH1 | 2.015110e-03 | 2.696 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.046820e-03 | 2.689 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.192305e-03 | 2.659 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.221380e-03 | 2.653 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.221380e-03 | 2.653 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.221380e-03 | 2.653 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 2.221380e-03 | 2.653 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.292077e-03 | 2.640 |
| R-HSA-1500931 | Cell-Cell communication | 2.313244e-03 | 2.636 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.510057e-03 | 2.600 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.510057e-03 | 2.600 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.646560e-03 | 2.577 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.693074e-03 | 2.570 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.709268e-03 | 2.567 |
| R-HSA-182971 | EGFR downregulation | 2.709268e-03 | 2.567 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.709268e-03 | 2.567 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.828015e-03 | 2.549 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.312297e-03 | 2.480 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.312297e-03 | 2.480 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.265943e-03 | 2.486 |
| R-HSA-156902 | Peptide chain elongation | 4.142656e-03 | 2.383 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.239600e-03 | 2.373 |
| R-HSA-392518 | Signal amplification | 3.895842e-03 | 2.409 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.087814e-03 | 2.510 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 3.969702e-03 | 2.401 |
| R-HSA-72766 | Translation | 4.437925e-03 | 2.353 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.052895e-03 | 2.515 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.210522e-03 | 2.493 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.562304e-03 | 2.448 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.221177e-03 | 2.492 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.221177e-03 | 2.492 |
| R-HSA-9664407 | Parasite infection | 3.221177e-03 | 2.492 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.266796e-03 | 2.486 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.571467e-03 | 2.447 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.895842e-03 | 2.409 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.895842e-03 | 2.409 |
| R-HSA-169911 | Regulation of Apoptosis | 4.239600e-03 | 2.373 |
| R-HSA-75893 | TNF signaling | 3.300091e-03 | 2.481 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.521583e-03 | 2.345 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.522675e-03 | 2.453 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.895842e-03 | 2.409 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.265943e-03 | 2.486 |
| R-HSA-450294 | MAP kinase activation | 4.521583e-03 | 2.345 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.895842e-03 | 2.409 |
| R-HSA-418990 | Adherens junctions interactions | 4.105418e-03 | 2.387 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.999865e-03 | 2.398 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.762304e-03 | 2.425 |
| R-HSA-186712 | Regulation of beta-cell development | 3.999865e-03 | 2.398 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.603267e-03 | 2.337 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.603267e-03 | 2.337 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.799823e-03 | 2.319 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.823971e-03 | 2.317 |
| R-HSA-4641258 | Degradation of DVL | 4.987355e-03 | 2.302 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.987355e-03 | 2.302 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.987355e-03 | 2.302 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.987355e-03 | 2.302 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.090012e-03 | 2.293 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.090012e-03 | 2.293 |
| R-HSA-168249 | Innate Immune System | 5.437151e-03 | 2.265 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.509154e-03 | 2.259 |
| R-HSA-73887 | Death Receptor Signaling | 5.510204e-03 | 2.259 |
| R-HSA-69541 | Stabilization of p53 | 5.818802e-03 | 2.235 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.818802e-03 | 2.235 |
| R-HSA-9648002 | RAS processing | 5.818802e-03 | 2.235 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 5.818802e-03 | 2.235 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 6.267136e-03 | 2.203 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 6.267136e-03 | 2.203 |
| R-HSA-8982491 | Glycogen metabolism | 6.267136e-03 | 2.203 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.304135e-03 | 2.200 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.304135e-03 | 2.200 |
| R-HSA-69206 | G1/S Transition | 6.320205e-03 | 2.199 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.375617e-03 | 2.195 |
| R-HSA-5218859 | Regulated Necrosis | 6.729554e-03 | 2.172 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 6.737841e-03 | 2.171 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 6.737841e-03 | 2.171 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 6.737841e-03 | 2.171 |
| R-HSA-69481 | G2/M Checkpoints | 6.805099e-03 | 2.167 |
| R-HSA-446728 | Cell junction organization | 6.878068e-03 | 2.163 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 7.006138e-03 | 2.155 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 7.231377e-03 | 2.141 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 7.231377e-03 | 2.141 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 7.231377e-03 | 2.141 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 7.231377e-03 | 2.141 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 7.231377e-03 | 2.141 |
| R-HSA-9683701 | Translation of Structural Proteins | 7.231377e-03 | 2.141 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.298799e-03 | 2.137 |
| R-HSA-9658195 | Leishmania infection | 7.382406e-03 | 2.132 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.382406e-03 | 2.132 |
| R-HSA-157118 | Signaling by NOTCH | 7.453853e-03 | 2.128 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.478294e-03 | 2.126 |
| R-HSA-448424 | Interleukin-17 signaling | 7.478294e-03 | 2.126 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.616063e-03 | 2.118 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.139559e-03 | 2.089 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 8.283218e-03 | 2.082 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 8.288720e-03 | 2.082 |
| R-HSA-5654743 | Signaling by FGFR4 | 8.288720e-03 | 2.082 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 8.288720e-03 | 2.082 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 8.666571e-03 | 2.062 |
| R-HSA-192823 | Viral mRNA Translation | 8.828823e-03 | 2.054 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 8.853384e-03 | 2.053 |
| R-HSA-9013694 | Signaling by NOTCH4 | 9.146324e-03 | 2.039 |
| R-HSA-1236394 | Signaling by ERBB4 | 9.146324e-03 | 2.039 |
| R-HSA-112316 | Neuronal System | 9.170596e-03 | 2.038 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.416188e-03 | 2.026 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 9.442594e-03 | 2.025 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 9.442594e-03 | 2.025 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 9.442594e-03 | 2.025 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 9.442594e-03 | 2.025 |
| R-HSA-5654741 | Signaling by FGFR3 | 9.442594e-03 | 2.025 |
| R-HSA-350054 | Notch-HLH transcription pathway | 9.519521e-03 | 2.021 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 9.519521e-03 | 2.021 |
| R-HSA-9669938 | Signaling by KIT in disease | 9.519521e-03 | 2.021 |
| R-HSA-421270 | Cell-cell junction organization | 9.772737e-03 | 2.010 |
| R-HSA-597592 | Post-translational protein modification | 9.919683e-03 | 2.004 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 9.980462e-03 | 2.001 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.005675e-02 | 1.998 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.005675e-02 | 1.998 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 1.005675e-02 | 1.998 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.033114e-02 | 1.986 |
| R-HSA-8849473 | PTK6 Expression | 1.059275e-02 | 1.975 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.069623e-02 | 1.971 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.069623e-02 | 1.971 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.069623e-02 | 1.971 |
| R-HSA-195721 | Signaling by WNT | 1.080850e-02 | 1.966 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.136142e-02 | 1.945 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.136142e-02 | 1.945 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 1.145105e-02 | 1.941 |
| R-HSA-392499 | Metabolism of proteins | 1.156396e-02 | 1.937 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.157128e-02 | 1.937 |
| R-HSA-73893 | DNA Damage Bypass | 1.205266e-02 | 1.919 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 1.205266e-02 | 1.919 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.205266e-02 | 1.919 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.205266e-02 | 1.919 |
| R-HSA-6806834 | Signaling by MET | 1.210394e-02 | 1.917 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.249497e-02 | 1.903 |
| R-HSA-9839394 | TGFBR3 expression | 1.249518e-02 | 1.903 |
| R-HSA-2559583 | Cellular Senescence | 1.251471e-02 | 1.903 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.268955e-02 | 1.897 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.277031e-02 | 1.894 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.338295e-02 | 1.873 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.351469e-02 | 1.869 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.351469e-02 | 1.869 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.351469e-02 | 1.869 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.357547e-02 | 1.867 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.359212e-02 | 1.867 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.428614e-02 | 1.845 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.428614e-02 | 1.845 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.428614e-02 | 1.845 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.439233e-02 | 1.842 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.440080e-02 | 1.842 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.474221e-02 | 1.831 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.486597e-02 | 1.828 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.495137e-02 | 1.825 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.495137e-02 | 1.825 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 1.538471e-02 | 1.813 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.548736e-02 | 1.810 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.565190e-02 | 1.805 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.565190e-02 | 1.805 |
| R-HSA-72649 | Translation initiation complex formation | 1.591139e-02 | 1.798 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.591139e-02 | 1.798 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.720297e-02 | 1.764 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.764836e-02 | 1.753 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.764836e-02 | 1.753 |
| R-HSA-177929 | Signaling by EGFR | 1.764836e-02 | 1.753 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.764836e-02 | 1.753 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.832583e-02 | 1.737 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.836731e-02 | 1.736 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.928914e-02 | 1.715 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.994833e-02 | 1.700 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 3.496106e-02 | 1.456 |
| R-HSA-9027284 | Erythropoietin activates RAS | 3.496106e-02 | 1.456 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.949911e-02 | 1.710 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.835656e-02 | 1.416 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.994409e-02 | 1.524 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.927446e-02 | 1.534 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.854879e-02 | 1.544 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.949911e-02 | 1.710 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.544310e-02 | 1.450 |
| R-HSA-5688426 | Deubiquitination | 2.740833e-02 | 1.562 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 3.169027e-02 | 1.499 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.588093e-02 | 1.587 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.383286e-02 | 1.623 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.588093e-02 | 1.587 |
| R-HSA-2029481 | FCGR activation | 2.217614e-02 | 1.654 |
| R-HSA-9033241 | Peroxisomal protein import | 2.046774e-02 | 1.689 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.274639e-02 | 1.485 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.715878e-02 | 1.430 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 2.261596e-02 | 1.646 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.751660e-02 | 1.560 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.854879e-02 | 1.544 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 2.854879e-02 | 1.544 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.544310e-02 | 1.450 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.880652e-02 | 1.411 |
| R-HSA-196780 | Biotin transport and metabolism | 3.496106e-02 | 1.456 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.217614e-02 | 1.654 |
| R-HSA-9711097 | Cellular response to starvation | 1.990420e-02 | 1.701 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.689757e-02 | 1.570 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.738099e-02 | 1.563 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.738099e-02 | 1.563 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.738099e-02 | 1.563 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.646429e-02 | 1.577 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.880652e-02 | 1.411 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.330474e-02 | 1.477 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.927446e-02 | 1.534 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.441018e-02 | 1.463 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.308187e-02 | 1.480 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.576913e-02 | 1.446 |
| R-HSA-9909396 | Circadian clock | 2.774576e-02 | 1.557 |
| R-HSA-163685 | Integration of energy metabolism | 3.184667e-02 | 1.497 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.308187e-02 | 1.480 |
| R-HSA-168255 | Influenza Infection | 3.445715e-02 | 1.463 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.448732e-02 | 1.462 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.880652e-02 | 1.411 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 3.715878e-02 | 1.430 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.905272e-02 | 1.408 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.996951e-02 | 1.398 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.996951e-02 | 1.398 |
| R-HSA-8852135 | Protein ubiquitination | 4.003028e-02 | 1.398 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.003028e-02 | 1.398 |
| R-HSA-917937 | Iron uptake and transport | 4.003028e-02 | 1.398 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.115352e-02 | 1.386 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.115352e-02 | 1.386 |
| R-HSA-5689603 | UCH proteinases | 4.151217e-02 | 1.382 |
| R-HSA-8953854 | Metabolism of RNA | 4.177198e-02 | 1.379 |
| R-HSA-72312 | rRNA processing | 4.219847e-02 | 1.375 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.302481e-02 | 1.366 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.302481e-02 | 1.366 |
| R-HSA-5619084 | ABC transporter disorders | 4.456821e-02 | 1.351 |
| R-HSA-4086400 | PCP/CE pathway | 4.456821e-02 | 1.351 |
| R-HSA-5545619 | XAV939 stabilizes AXIN | 4.497767e-02 | 1.347 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 4.550365e-02 | 1.342 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.610076e-02 | 1.336 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.754287e-02 | 1.323 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.774714e-02 | 1.321 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 4.809945e-02 | 1.318 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.865792e-02 | 1.313 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.904260e-02 | 1.309 |
| R-HSA-3928664 | Ephrin signaling | 4.924653e-02 | 1.308 |
| R-HSA-432142 | Platelet sensitization by LDL | 4.924653e-02 | 1.308 |
| R-HSA-9831926 | Nephron development | 4.924653e-02 | 1.308 |
| R-HSA-977225 | Amyloid fiber formation | 4.938260e-02 | 1.306 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.104866e-02 | 1.292 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.128137e-02 | 1.290 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.128137e-02 | 1.290 |
| R-HSA-9675135 | Diseases of DNA repair | 5.128137e-02 | 1.290 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.274524e-02 | 1.278 |
| R-HSA-844456 | The NLRP3 inflammasome | 5.309665e-02 | 1.275 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.557644e-02 | 1.255 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.557644e-02 | 1.255 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 5.704993e-02 | 1.244 |
| R-HSA-373753 | Nephrin family interactions | 5.704993e-02 | 1.244 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.847554e-02 | 1.233 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.858668e-02 | 1.232 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 5.951789e-02 | 1.225 |
| R-HSA-1299503 | TWIK related potassium channel (TREK) | 5.951789e-02 | 1.225 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.983523e-02 | 1.223 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.995703e-02 | 1.222 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.995703e-02 | 1.222 |
| R-HSA-9748787 | Azathioprine ADME | 6.083709e-02 | 1.216 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 6.110234e-02 | 1.214 |
| R-HSA-70268 | Pyruvate metabolism | 6.168314e-02 | 1.210 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.298379e-02 | 1.201 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.609542e-02 | 1.180 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.609542e-02 | 1.180 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.609542e-02 | 1.180 |
| R-HSA-6798695 | Neutrophil degranulation | 6.681753e-02 | 1.175 |
| R-HSA-202424 | Downstream TCR signaling | 6.740594e-02 | 1.171 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 6.948907e-02 | 1.158 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.136894e-02 | 1.146 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.339431e-02 | 1.134 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.339431e-02 | 1.134 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.339431e-02 | 1.134 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 7.381585e-02 | 1.132 |
| R-HSA-982772 | Growth hormone receptor signaling | 7.381585e-02 | 1.132 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 7.383761e-02 | 1.132 |
| R-HSA-5579006 | Defective GSS causes GSS deficiency | 7.383761e-02 | 1.132 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 7.383761e-02 | 1.132 |
| R-HSA-9753281 | Paracetamol ADME | 7.385518e-02 | 1.132 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.728082e-02 | 1.112 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.728082e-02 | 1.112 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 7.822670e-02 | 1.107 |
| R-HSA-5621480 | Dectin-2 family | 7.938132e-02 | 1.100 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.027156e-02 | 1.095 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 8.508211e-02 | 1.070 |
| R-HSA-205025 | NADE modulates death signalling | 8.794017e-02 | 1.056 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 8.799634e-02 | 1.056 |
| R-HSA-190236 | Signaling by FGFR | 8.837373e-02 | 1.054 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 9.022069e-02 | 1.045 |
| R-HSA-9020702 | Interleukin-1 signaling | 9.521167e-02 | 1.021 |
| R-HSA-622312 | Inflammasomes | 9.664146e-02 | 1.015 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 9.664146e-02 | 1.015 |
| R-HSA-373755 | Semaphorin interactions | 9.698630e-02 | 1.013 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.014214e-01 | 0.994 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.014214e-01 | 0.994 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.014214e-01 | 0.994 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.014214e-01 | 0.994 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.017830e-01 | 0.992 |
| R-HSA-8849472 | PTK6 Down-Regulation | 1.018289e-01 | 0.992 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 1.018289e-01 | 0.992 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 1.018289e-01 | 0.992 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 1.018289e-01 | 0.992 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 1.018289e-01 | 0.992 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 1.018289e-01 | 0.992 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 1.018289e-01 | 0.992 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 1.018289e-01 | 0.992 |
| R-HSA-9927353 | Co-inhibition by BTLA | 1.018289e-01 | 0.992 |
| R-HSA-8866376 | Reelin signalling pathway | 1.018289e-01 | 0.992 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.022916e-01 | 0.990 |
| R-HSA-983712 | Ion channel transport | 1.029871e-01 | 0.987 |
| R-HSA-9833110 | RSV-host interactions | 1.047041e-01 | 0.980 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.057943e-01 | 0.976 |
| R-HSA-2424491 | DAP12 signaling | 1.062654e-01 | 0.974 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.062654e-01 | 0.974 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.064818e-01 | 0.973 |
| R-HSA-418346 | Platelet homeostasis | 1.096066e-01 | 0.960 |
| R-HSA-69239 | Synthesis of DNA | 1.120959e-01 | 0.950 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.127517e-01 | 0.948 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.140471e-01 | 0.943 |
| R-HSA-69242 | S Phase | 1.140471e-01 | 0.943 |
| R-HSA-166520 | Signaling by NTRKs | 1.140471e-01 | 0.943 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.146103e-01 | 0.941 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 1.155069e-01 | 0.937 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.155069e-01 | 0.937 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 1.155069e-01 | 0.937 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.155069e-01 | 0.937 |
| R-HSA-389397 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | 1.155069e-01 | 0.937 |
| R-HSA-9667769 | Acetylcholine inhibits contraction of outer hair cells | 1.155069e-01 | 0.937 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.155069e-01 | 0.937 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.155069e-01 | 0.937 |
| R-HSA-202403 | TCR signaling | 1.197130e-01 | 0.922 |
| R-HSA-354192 | Integrin signaling | 1.211522e-01 | 0.917 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.211522e-01 | 0.917 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.211522e-01 | 0.917 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.211522e-01 | 0.917 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.211522e-01 | 0.917 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.211522e-01 | 0.917 |
| R-HSA-449147 | Signaling by Interleukins | 1.244748e-01 | 0.905 |
| R-HSA-9609507 | Protein localization | 1.247832e-01 | 0.904 |
| R-HSA-69306 | DNA Replication | 1.247832e-01 | 0.904 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 1.249124e-01 | 0.903 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.262231e-01 | 0.899 |
| R-HSA-212436 | Generic Transcription Pathway | 1.262805e-01 | 0.899 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.269850e-01 | 0.896 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.275476e-01 | 0.894 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.289774e-01 | 0.889 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 1.289774e-01 | 0.889 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 1.289774e-01 | 0.889 |
| R-HSA-164944 | Nef and signal transduction | 1.289774e-01 | 0.889 |
| R-HSA-1989781 | PPARA activates gene expression | 1.292046e-01 | 0.889 |
| R-HSA-4086398 | Ca2+ pathway | 1.294171e-01 | 0.888 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.313437e-01 | 0.882 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.328501e-01 | 0.877 |
| R-HSA-73894 | DNA Repair | 1.330602e-01 | 0.876 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.336967e-01 | 0.874 |
| R-HSA-162587 | HIV Life Cycle | 1.336967e-01 | 0.874 |
| R-HSA-5357801 | Programmed Cell Death | 1.345922e-01 | 0.871 |
| R-HSA-381042 | PERK regulates gene expression | 1.365113e-01 | 0.865 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.365113e-01 | 0.865 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.417233e-01 | 0.849 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.417233e-01 | 0.849 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.422437e-01 | 0.847 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 1.422437e-01 | 0.847 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.422437e-01 | 0.847 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.422437e-01 | 0.847 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 1.422437e-01 | 0.847 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.422437e-01 | 0.847 |
| R-HSA-9026762 | Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | 1.422437e-01 | 0.847 |
| R-HSA-109581 | Apoptosis | 1.452275e-01 | 0.838 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.468907e-01 | 0.833 |
| R-HSA-397014 | Muscle contraction | 1.488040e-01 | 0.827 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.508880e-01 | 0.821 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.540858e-01 | 0.812 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 1.551276e-01 | 0.809 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.553086e-01 | 0.809 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.553086e-01 | 0.809 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.553086e-01 | 0.809 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 1.576008e-01 | 0.802 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.629657e-01 | 0.788 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.650802e-01 | 0.782 |
| R-HSA-9613354 | Lipophagy | 1.681754e-01 | 0.774 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.681754e-01 | 0.774 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.681754e-01 | 0.774 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.681754e-01 | 0.774 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.681754e-01 | 0.774 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.683630e-01 | 0.774 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.683630e-01 | 0.774 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.725359e-01 | 0.763 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.737906e-01 | 0.760 |
| R-HSA-9679506 | SARS-CoV Infections | 1.775825e-01 | 0.751 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.786509e-01 | 0.748 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.792461e-01 | 0.747 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 1.792461e-01 | 0.747 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.808470e-01 | 0.743 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.808470e-01 | 0.743 |
| R-HSA-111458 | Formation of apoptosome | 1.808470e-01 | 0.743 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.808470e-01 | 0.743 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 1.808470e-01 | 0.743 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.808470e-01 | 0.743 |
| R-HSA-162906 | HIV Infection | 1.813880e-01 | 0.741 |
| R-HSA-8854214 | TBC/RABGAPs | 1.847275e-01 | 0.733 |
| R-HSA-373752 | Netrin-1 signaling | 1.902329e-01 | 0.721 |
| R-HSA-2172127 | DAP12 interactions | 1.902329e-01 | 0.721 |
| R-HSA-5576891 | Cardiac conduction | 1.908395e-01 | 0.719 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.914893e-01 | 0.718 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.933263e-01 | 0.714 |
| R-HSA-192814 | vRNA Synthesis | 1.933263e-01 | 0.714 |
| R-HSA-425381 | Bicarbonate transporters | 1.933263e-01 | 0.714 |
| R-HSA-391908 | Prostanoid ligand receptors | 1.933263e-01 | 0.714 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.933263e-01 | 0.714 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.957601e-01 | 0.708 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.957601e-01 | 0.708 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.991347e-01 | 0.701 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.993334e-01 | 0.700 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 2.013072e-01 | 0.696 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 2.013072e-01 | 0.696 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 2.045621e-01 | 0.689 |
| R-HSA-2022923 | DS-GAG biosynthesis | 2.056162e-01 | 0.687 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 2.056162e-01 | 0.687 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.056162e-01 | 0.687 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 2.056162e-01 | 0.687 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.056162e-01 | 0.687 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.086712e-01 | 0.681 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.141829e-01 | 0.669 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 2.177197e-01 | 0.662 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.177197e-01 | 0.662 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.177197e-01 | 0.662 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.177197e-01 | 0.662 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.177197e-01 | 0.662 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.177197e-01 | 0.662 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.177197e-01 | 0.662 |
| R-HSA-8983711 | OAS antiviral response | 2.177197e-01 | 0.662 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.177197e-01 | 0.662 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.256071e-01 | 0.647 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 2.270399e-01 | 0.644 |
| R-HSA-1296071 | Potassium Channels | 2.270399e-01 | 0.644 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.296394e-01 | 0.639 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 2.296394e-01 | 0.639 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.349077e-01 | 0.629 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.353632e-01 | 0.628 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.405448e-01 | 0.619 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.413783e-01 | 0.617 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.413783e-01 | 0.617 |
| R-HSA-5578768 | Physiological factors | 2.413783e-01 | 0.617 |
| R-HSA-417957 | P2Y receptors | 2.413783e-01 | 0.617 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.413783e-01 | 0.617 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.413783e-01 | 0.617 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.461883e-01 | 0.609 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.529390e-01 | 0.597 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.529390e-01 | 0.597 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.529390e-01 | 0.597 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.529390e-01 | 0.597 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.529390e-01 | 0.597 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.529390e-01 | 0.597 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.574882e-01 | 0.589 |
| R-HSA-5578775 | Ion homeostasis | 2.574882e-01 | 0.589 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.574882e-01 | 0.589 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.584995e-01 | 0.588 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.584995e-01 | 0.588 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.631418e-01 | 0.580 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.643242e-01 | 0.578 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 2.643242e-01 | 0.578 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.643242e-01 | 0.578 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.643242e-01 | 0.578 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.643242e-01 | 0.578 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 2.687961e-01 | 0.571 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.755367e-01 | 0.560 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 2.755367e-01 | 0.560 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 2.755367e-01 | 0.560 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.755367e-01 | 0.560 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.755367e-01 | 0.560 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 2.755367e-01 | 0.560 |
| R-HSA-9927020 | Heme assimilation | 2.755367e-01 | 0.560 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 2.755367e-01 | 0.560 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.755367e-01 | 0.560 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.755367e-01 | 0.560 |
| R-HSA-74160 | Gene expression (Transcription) | 2.770958e-01 | 0.557 |
| R-HSA-8873719 | RAB geranylgeranylation | 2.801012e-01 | 0.553 |
| R-HSA-379724 | tRNA Aminoacylation | 2.801012e-01 | 0.553 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.865789e-01 | 0.543 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 2.865789e-01 | 0.543 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.865789e-01 | 0.543 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.865789e-01 | 0.543 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.865789e-01 | 0.543 |
| R-HSA-9707616 | Heme signaling | 2.913934e-01 | 0.536 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.974534e-01 | 0.527 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.974534e-01 | 0.527 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.974534e-01 | 0.527 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 2.974534e-01 | 0.527 |
| R-HSA-9026395 | Biosynthesis of DHA-derived sulfido conjugates | 2.974534e-01 | 0.527 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 3.026632e-01 | 0.519 |
| R-HSA-9748784 | Drug ADME | 3.027623e-01 | 0.519 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.081629e-01 | 0.511 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 3.081629e-01 | 0.511 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 3.081629e-01 | 0.511 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 3.081629e-01 | 0.511 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 3.081629e-01 | 0.511 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.082868e-01 | 0.511 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 3.133665e-01 | 0.504 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.175337e-01 | 0.498 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 3.187098e-01 | 0.497 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.187098e-01 | 0.497 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.187098e-01 | 0.497 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.187098e-01 | 0.497 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.187098e-01 | 0.497 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.187098e-01 | 0.497 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.187098e-01 | 0.497 |
| R-HSA-9629569 | Protein hydroxylation | 3.187098e-01 | 0.497 |
| R-HSA-445144 | Signal transduction by L1 | 3.187098e-01 | 0.497 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 3.187098e-01 | 0.497 |
| R-HSA-9830369 | Kidney development | 3.195065e-01 | 0.496 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 3.290965e-01 | 0.483 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.290965e-01 | 0.483 |
| R-HSA-210991 | Basigin interactions | 3.290965e-01 | 0.483 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.300392e-01 | 0.481 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 3.362516e-01 | 0.473 |
| R-HSA-2022870 | CS-GAG biosynthesis | 3.393255e-01 | 0.469 |
| R-HSA-174403 | Glutathione synthesis and recycling | 3.393255e-01 | 0.469 |
| R-HSA-189445 | Metabolism of porphyrins | 3.418070e-01 | 0.466 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.418070e-01 | 0.466 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.473479e-01 | 0.459 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.493992e-01 | 0.457 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.493992e-01 | 0.457 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.493992e-01 | 0.457 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.493992e-01 | 0.457 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.593199e-01 | 0.445 |
| R-HSA-9018682 | Biosynthesis of maresins | 3.593199e-01 | 0.445 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.593199e-01 | 0.445 |
| R-HSA-200425 | Carnitine shuttle | 3.593199e-01 | 0.445 |
| R-HSA-3000170 | Syndecan interactions | 3.593199e-01 | 0.445 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.593199e-01 | 0.445 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.593199e-01 | 0.445 |
| R-HSA-194138 | Signaling by VEGF | 3.633299e-01 | 0.440 |
| R-HSA-211999 | CYP2E1 reactions | 3.690899e-01 | 0.433 |
| R-HSA-429947 | Deadenylation of mRNA | 3.690899e-01 | 0.433 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.690899e-01 | 0.433 |
| R-HSA-114608 | Platelet degranulation | 3.716199e-01 | 0.430 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.787115e-01 | 0.422 |
| R-HSA-2160916 | Hyaluronan degradation | 3.787115e-01 | 0.422 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.787115e-01 | 0.422 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.787115e-01 | 0.422 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.787115e-01 | 0.422 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 3.802414e-01 | 0.420 |
| R-HSA-9659379 | Sensory processing of sound | 3.856581e-01 | 0.414 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.881870e-01 | 0.411 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.881870e-01 | 0.411 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.881870e-01 | 0.411 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.899554e-01 | 0.409 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 3.964292e-01 | 0.402 |
| R-HSA-8949613 | Cristae formation | 3.975185e-01 | 0.401 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.975185e-01 | 0.401 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.975185e-01 | 0.401 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.975185e-01 | 0.401 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.975185e-01 | 0.401 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.004573e-01 | 0.397 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.067083e-01 | 0.391 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.167756e-01 | 0.380 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.246711e-01 | 0.372 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.246711e-01 | 0.372 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.246711e-01 | 0.372 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.302552e-01 | 0.366 |
| R-HSA-5694530 | Cargo concentration in the ER | 4.334483e-01 | 0.363 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.380295e-01 | 0.358 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 4.420922e-01 | 0.354 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.420922e-01 | 0.354 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.506047e-01 | 0.346 |
| R-HSA-9930044 | Nuclear RNA decay | 4.506047e-01 | 0.346 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.506047e-01 | 0.346 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.506047e-01 | 0.346 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.506047e-01 | 0.346 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.539980e-01 | 0.343 |
| R-HSA-211859 | Biological oxidations | 4.562078e-01 | 0.341 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.589879e-01 | 0.338 |
| R-HSA-2024101 | CS/DS degradation | 4.589879e-01 | 0.338 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.589879e-01 | 0.338 |
| R-HSA-189483 | Heme degradation | 4.589879e-01 | 0.338 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.589879e-01 | 0.338 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 4.589879e-01 | 0.338 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 4.672436e-01 | 0.330 |
| R-HSA-2142845 | Hyaluronan metabolism | 4.672436e-01 | 0.330 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 4.672436e-01 | 0.330 |
| R-HSA-5673000 | RAF activation | 4.672436e-01 | 0.330 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.741510e-01 | 0.324 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.741510e-01 | 0.324 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.753739e-01 | 0.323 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 4.753739e-01 | 0.323 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 4.785012e-01 | 0.320 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.833805e-01 | 0.316 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.833805e-01 | 0.316 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.833805e-01 | 0.316 |
| R-HSA-9845576 | Glycosphingolipid transport | 4.833805e-01 | 0.316 |
| R-HSA-3371511 | HSF1 activation | 4.833805e-01 | 0.316 |
| R-HSA-1296072 | Voltage gated Potassium channels | 4.912655e-01 | 0.309 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.912655e-01 | 0.309 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.912655e-01 | 0.309 |
| R-HSA-196757 | Metabolism of folate and pterines | 4.912655e-01 | 0.309 |
| R-HSA-8875878 | MET promotes cell motility | 4.990306e-01 | 0.302 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.990306e-01 | 0.302 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 4.990306e-01 | 0.302 |
| R-HSA-8951664 | Neddylation | 5.062424e-01 | 0.296 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 5.066777e-01 | 0.295 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.066777e-01 | 0.295 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 5.066777e-01 | 0.295 |
| R-HSA-201556 | Signaling by ALK | 5.066777e-01 | 0.295 |
| R-HSA-3371568 | Attenuation phase | 5.142085e-01 | 0.289 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.142085e-01 | 0.289 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.142085e-01 | 0.289 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.142085e-01 | 0.289 |
| R-HSA-71240 | Tryptophan catabolism | 5.142085e-01 | 0.289 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 5.142085e-01 | 0.289 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.216248e-01 | 0.283 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.216248e-01 | 0.283 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.216248e-01 | 0.283 |
| R-HSA-5674135 | MAP2K and MAPK activation | 5.289283e-01 | 0.277 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 5.289283e-01 | 0.277 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.289283e-01 | 0.277 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.289283e-01 | 0.277 |
| R-HSA-189451 | Heme biosynthesis | 5.289283e-01 | 0.277 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.318204e-01 | 0.274 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.318204e-01 | 0.274 |
| R-HSA-5668914 | Diseases of metabolism | 5.328786e-01 | 0.273 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 5.349127e-01 | 0.272 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.361207e-01 | 0.271 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.361207e-01 | 0.271 |
| R-HSA-165159 | MTOR signalling | 5.361207e-01 | 0.271 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 5.570485e-01 | 0.254 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.570485e-01 | 0.254 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.570485e-01 | 0.254 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.638132e-01 | 0.249 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.638132e-01 | 0.249 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.638132e-01 | 0.249 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.638132e-01 | 0.249 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.704751e-01 | 0.244 |
| R-HSA-1483191 | Synthesis of PC | 5.704751e-01 | 0.244 |
| R-HSA-70263 | Gluconeogenesis | 5.770357e-01 | 0.239 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 5.892748e-01 | 0.230 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.961245e-01 | 0.225 |
| R-HSA-912446 | Meiotic recombination | 5.961245e-01 | 0.225 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 5.969223e-01 | 0.224 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.976369e-01 | 0.224 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.976369e-01 | 0.224 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.022948e-01 | 0.220 |
| R-HSA-9824439 | Bacterial Infection Pathways | 6.044328e-01 | 0.219 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.083712e-01 | 0.216 |
| R-HSA-8957322 | Metabolism of steroids | 6.088970e-01 | 0.215 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 6.202480e-01 | 0.207 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.202480e-01 | 0.207 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.219565e-01 | 0.206 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.219565e-01 | 0.206 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.260512e-01 | 0.203 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.260512e-01 | 0.203 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 6.429361e-01 | 0.192 |
| R-HSA-180786 | Extension of Telomeres | 6.429361e-01 | 0.192 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.483940e-01 | 0.188 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.483940e-01 | 0.188 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.486674e-01 | 0.188 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.526024e-01 | 0.185 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 6.537687e-01 | 0.185 |
| R-HSA-112043 | PLC beta mediated events | 6.537687e-01 | 0.185 |
| R-HSA-445717 | Aquaporin-mediated transport | 6.537687e-01 | 0.185 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.590616e-01 | 0.181 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.590616e-01 | 0.181 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.590616e-01 | 0.181 |
| R-HSA-1268020 | Mitochondrial protein import | 6.590616e-01 | 0.181 |
| R-HSA-9843745 | Adipogenesis | 6.599491e-01 | 0.180 |
| R-HSA-211981 | Xenobiotics | 6.694069e-01 | 0.174 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.694069e-01 | 0.174 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.794394e-01 | 0.168 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.843414e-01 | 0.165 |
| R-HSA-112040 | G-protein mediated events | 6.843414e-01 | 0.165 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.891688e-01 | 0.162 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.891688e-01 | 0.162 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.986039e-01 | 0.156 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.986039e-01 | 0.156 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.986039e-01 | 0.156 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.009750e-01 | 0.154 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.032140e-01 | 0.153 |
| R-HSA-9638482 | Metal ion assimilation from the host | 7.032140e-01 | 0.153 |
| R-HSA-8978934 | Metabolism of cofactors | 7.032140e-01 | 0.153 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.077538e-01 | 0.150 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 7.079364e-01 | 0.150 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.122245e-01 | 0.147 |
| R-HSA-9749641 | Aspirin ADME | 7.122245e-01 | 0.147 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.166271e-01 | 0.145 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.209625e-01 | 0.142 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.209625e-01 | 0.142 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 7.209625e-01 | 0.142 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.252319e-01 | 0.140 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.335765e-01 | 0.135 |
| R-HSA-216083 | Integrin cell surface interactions | 7.335765e-01 | 0.135 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 7.376537e-01 | 0.132 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.456225e-01 | 0.127 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.485877e-01 | 0.126 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.495160e-01 | 0.125 |
| R-HSA-8939211 | ESR-mediated signaling | 7.556366e-01 | 0.122 |
| R-HSA-1500620 | Meiosis | 7.608441e-01 | 0.119 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.681112e-01 | 0.115 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 7.681112e-01 | 0.115 |
| R-HSA-73884 | Base Excision Repair | 7.819921e-01 | 0.107 |
| R-HSA-4839726 | Chromatin organization | 7.822577e-01 | 0.107 |
| R-HSA-1474290 | Collagen formation | 7.981851e-01 | 0.098 |
| R-HSA-2168880 | Scavenging of heme from plasma | 8.043217e-01 | 0.095 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 8.073199e-01 | 0.093 |
| R-HSA-157579 | Telomere Maintenance | 8.102724e-01 | 0.091 |
| R-HSA-416476 | G alpha (q) signalling events | 8.121353e-01 | 0.090 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.131798e-01 | 0.090 |
| R-HSA-422356 | Regulation of insulin secretion | 8.131798e-01 | 0.090 |
| R-HSA-3214847 | HATs acetylate histones | 8.160429e-01 | 0.088 |
| R-HSA-70171 | Glycolysis | 8.188622e-01 | 0.087 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.243724e-01 | 0.084 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 8.243724e-01 | 0.084 |
| R-HSA-1483255 | PI Metabolism | 8.243724e-01 | 0.084 |
| R-HSA-111885 | Opioid Signalling | 8.297157e-01 | 0.081 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.353683e-01 | 0.078 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.373108e-01 | 0.077 |
| R-HSA-211000 | Gene Silencing by RNA | 8.399213e-01 | 0.076 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.419872e-01 | 0.075 |
| R-HSA-382551 | Transport of small molecules | 8.468851e-01 | 0.072 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.585409e-01 | 0.066 |
| R-HSA-70326 | Glucose metabolism | 8.670251e-01 | 0.062 |
| R-HSA-3371556 | Cellular response to heat stress | 8.750024e-01 | 0.058 |
| R-HSA-73886 | Chromosome Maintenance | 8.750024e-01 | 0.058 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.806710e-01 | 0.055 |
| R-HSA-1474165 | Reproduction | 8.945662e-01 | 0.048 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.977805e-01 | 0.047 |
| R-HSA-1474244 | Extracellular matrix organization | 9.066379e-01 | 0.043 |
| R-HSA-9758941 | Gastrulation | 9.238422e-01 | 0.034 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.250135e-01 | 0.034 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.273027e-01 | 0.033 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.423921e-01 | 0.026 |
| R-HSA-5619102 | SLC transporter disorders | 9.423921e-01 | 0.026 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.446276e-01 | 0.025 |
| R-HSA-72306 | tRNA processing | 9.458595e-01 | 0.024 |
| R-HSA-611105 | Respiratory electron transport | 9.521828e-01 | 0.021 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.544471e-01 | 0.020 |
| R-HSA-1483257 | Phospholipid metabolism | 9.549457e-01 | 0.020 |
| R-HSA-3781865 | Diseases of glycosylation | 9.564376e-01 | 0.019 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.577703e-01 | 0.019 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.627072e-01 | 0.017 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.675772e-01 | 0.014 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.675772e-01 | 0.014 |
| R-HSA-72172 | mRNA Splicing | 9.685703e-01 | 0.014 |
| R-HSA-6805567 | Keratinization | 9.695331e-01 | 0.013 |
| R-HSA-388396 | GPCR downstream signalling | 9.839797e-01 | 0.007 |
| R-HSA-556833 | Metabolism of lipids | 9.873015e-01 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.885578e-01 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 9.900169e-01 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 9.900169e-01 | 0.004 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.900857e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.932684e-01 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 9.958353e-01 | 0.002 |
| R-HSA-1430728 | Metabolism | 9.963432e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.862 | 0.051 | 2 | 0.881 |
CDC7 |
0.855 | 0.100 | 1 | 0.899 |
MOS |
0.850 | 0.077 | 1 | 0.927 |
GCN2 |
0.849 | 0.015 | 2 | 0.797 |
DSTYK |
0.847 | 0.039 | 2 | 0.880 |
PIM3 |
0.847 | 0.035 | -3 | 0.867 |
CLK3 |
0.847 | 0.055 | 1 | 0.812 |
PRPK |
0.846 | -0.047 | -1 | 0.583 |
NLK |
0.846 | 0.136 | 1 | 0.797 |
TGFBR2 |
0.845 | 0.095 | -2 | 0.846 |
NEK6 |
0.844 | 0.027 | -2 | 0.891 |
BMPR2 |
0.844 | 0.070 | -2 | 0.905 |
ERK5 |
0.843 | 0.121 | 1 | 0.803 |
CDKL1 |
0.842 | 0.053 | -3 | 0.832 |
PRKD1 |
0.842 | 0.053 | -3 | 0.860 |
IKKB |
0.841 | -0.037 | -2 | 0.748 |
NDR2 |
0.840 | -0.017 | -3 | 0.873 |
TBK1 |
0.840 | -0.029 | 1 | 0.737 |
MTOR |
0.840 | -0.098 | 1 | 0.781 |
RAF1 |
0.840 | -0.088 | 1 | 0.855 |
CAMK1B |
0.839 | -0.010 | -3 | 0.876 |
NEK7 |
0.839 | -0.014 | -3 | 0.881 |
CDKL5 |
0.839 | 0.077 | -3 | 0.817 |
ULK2 |
0.839 | -0.077 | 2 | 0.782 |
ATR |
0.839 | 0.019 | 1 | 0.843 |
WNK1 |
0.837 | 0.022 | -2 | 0.888 |
PDHK4 |
0.837 | -0.159 | 1 | 0.861 |
RSK2 |
0.837 | 0.049 | -3 | 0.791 |
PRKD2 |
0.837 | 0.065 | -3 | 0.783 |
PKN3 |
0.836 | 0.005 | -3 | 0.856 |
IKKE |
0.836 | -0.034 | 1 | 0.728 |
MST4 |
0.836 | 0.011 | 2 | 0.845 |
SMG1 |
0.836 | 0.293 | 1 | 0.794 |
SKMLCK |
0.835 | 0.026 | -2 | 0.869 |
MLK1 |
0.835 | -0.001 | 2 | 0.810 |
RSK3 |
0.835 | 0.038 | -3 | 0.799 |
NIK |
0.835 | -0.012 | -3 | 0.900 |
SRPK1 |
0.834 | 0.052 | -3 | 0.784 |
CAMLCK |
0.834 | 0.048 | -2 | 0.856 |
NEK9 |
0.834 | 0.042 | 2 | 0.836 |
DAPK2 |
0.834 | 0.056 | -3 | 0.889 |
NDR1 |
0.834 | -0.015 | -3 | 0.855 |
CAMK2G |
0.833 | -0.074 | 2 | 0.812 |
BMPR1B |
0.833 | 0.110 | 1 | 0.830 |
CHAK2 |
0.833 | -0.031 | -1 | 0.570 |
RIPK3 |
0.833 | -0.005 | 3 | 0.721 |
NUAK2 |
0.833 | -0.000 | -3 | 0.843 |
PKCD |
0.833 | 0.023 | 2 | 0.789 |
P90RSK |
0.832 | 0.026 | -3 | 0.802 |
WNK3 |
0.832 | -0.023 | 1 | 0.836 |
PIM1 |
0.832 | 0.031 | -3 | 0.793 |
HIPK4 |
0.832 | 0.032 | 1 | 0.779 |
MARK4 |
0.832 | -0.015 | 4 | 0.870 |
PDHK1 |
0.831 | -0.142 | 1 | 0.850 |
AURC |
0.831 | 0.051 | -2 | 0.667 |
MAPKAPK3 |
0.831 | 0.038 | -3 | 0.795 |
AMPKA1 |
0.831 | -0.012 | -3 | 0.860 |
HUNK |
0.830 | -0.101 | 2 | 0.821 |
IKKA |
0.830 | -0.049 | -2 | 0.737 |
PKN2 |
0.829 | -0.004 | -3 | 0.849 |
GRK1 |
0.829 | 0.008 | -2 | 0.826 |
GRK5 |
0.829 | -0.095 | -3 | 0.880 |
P70S6KB |
0.828 | 0.011 | -3 | 0.808 |
IRE1 |
0.828 | -0.018 | 1 | 0.819 |
ICK |
0.828 | 0.006 | -3 | 0.866 |
LATS2 |
0.828 | -0.032 | -5 | 0.757 |
ATM |
0.828 | 0.023 | 1 | 0.786 |
PKACG |
0.827 | 0.003 | -2 | 0.750 |
MLK3 |
0.827 | 0.023 | 2 | 0.746 |
TGFBR1 |
0.827 | 0.061 | -2 | 0.836 |
BCKDK |
0.827 | -0.119 | -1 | 0.531 |
ALK4 |
0.827 | 0.061 | -2 | 0.858 |
MLK2 |
0.827 | -0.019 | 2 | 0.803 |
SRPK2 |
0.826 | 0.044 | -3 | 0.704 |
CAMK2D |
0.826 | -0.036 | -3 | 0.861 |
ULK1 |
0.826 | -0.128 | -3 | 0.834 |
KIS |
0.826 | 0.009 | 1 | 0.647 |
PKR |
0.826 | 0.054 | 1 | 0.861 |
TTBK2 |
0.826 | -0.039 | 2 | 0.737 |
SRPK3 |
0.825 | 0.052 | -3 | 0.766 |
AMPKA2 |
0.825 | -0.001 | -3 | 0.826 |
FAM20C |
0.825 | 0.031 | 2 | 0.628 |
TSSK1 |
0.825 | -0.002 | -3 | 0.879 |
TSSK2 |
0.824 | -0.012 | -5 | 0.779 |
GRK6 |
0.824 | -0.036 | 1 | 0.855 |
MAPKAPK2 |
0.824 | 0.017 | -3 | 0.747 |
ALK2 |
0.824 | 0.090 | -2 | 0.854 |
CDK8 |
0.824 | -0.011 | 1 | 0.611 |
ACVR2B |
0.823 | 0.079 | -2 | 0.838 |
PAK3 |
0.823 | 0.003 | -2 | 0.771 |
PRKD3 |
0.823 | 0.037 | -3 | 0.772 |
NEK2 |
0.823 | 0.008 | 2 | 0.811 |
ANKRD3 |
0.823 | -0.077 | 1 | 0.863 |
GRK4 |
0.823 | -0.071 | -2 | 0.864 |
MELK |
0.823 | 0.017 | -3 | 0.814 |
NIM1 |
0.823 | -0.051 | 3 | 0.771 |
AURB |
0.823 | 0.052 | -2 | 0.660 |
PAK1 |
0.823 | -0.003 | -2 | 0.776 |
IRE2 |
0.822 | -0.018 | 2 | 0.750 |
PKCA |
0.822 | 0.016 | 2 | 0.733 |
PKCB |
0.822 | 0.003 | 2 | 0.741 |
MASTL |
0.821 | -0.160 | -2 | 0.826 |
QSK |
0.820 | -0.000 | 4 | 0.856 |
RIPK1 |
0.820 | -0.104 | 1 | 0.830 |
ACVR2A |
0.820 | 0.051 | -2 | 0.831 |
MNK2 |
0.820 | -0.008 | -2 | 0.789 |
LATS1 |
0.820 | -0.025 | -3 | 0.893 |
PERK |
0.820 | 0.046 | -2 | 0.880 |
PKG2 |
0.820 | 0.056 | -2 | 0.682 |
DLK |
0.819 | -0.146 | 1 | 0.842 |
CAMK4 |
0.819 | -0.043 | -3 | 0.826 |
PLK1 |
0.819 | -0.031 | -2 | 0.835 |
PKCG |
0.819 | -0.022 | 2 | 0.746 |
CDK7 |
0.819 | -0.015 | 1 | 0.623 |
YSK4 |
0.819 | -0.020 | 1 | 0.780 |
PAK6 |
0.819 | 0.055 | -2 | 0.693 |
RSK4 |
0.818 | 0.019 | -3 | 0.766 |
PKCZ |
0.818 | -0.032 | 2 | 0.783 |
QIK |
0.818 | -0.044 | -3 | 0.850 |
CDK19 |
0.818 | -0.013 | 1 | 0.566 |
MYLK4 |
0.818 | 0.053 | -2 | 0.773 |
CHAK1 |
0.818 | -0.037 | 2 | 0.755 |
NUAK1 |
0.818 | -0.041 | -3 | 0.801 |
VRK2 |
0.817 | -0.006 | 1 | 0.881 |
CAMK2B |
0.817 | -0.032 | 2 | 0.782 |
MLK4 |
0.817 | -0.036 | 2 | 0.726 |
DYRK2 |
0.817 | 0.002 | 1 | 0.657 |
CLK1 |
0.817 | 0.045 | -3 | 0.755 |
MSK2 |
0.817 | -0.026 | -3 | 0.779 |
CLK4 |
0.817 | 0.026 | -3 | 0.778 |
SGK3 |
0.816 | 0.033 | -3 | 0.779 |
MEK1 |
0.816 | -0.034 | 2 | 0.823 |
GRK7 |
0.816 | -0.003 | 1 | 0.773 |
PKACB |
0.816 | 0.025 | -2 | 0.679 |
PHKG1 |
0.816 | -0.017 | -3 | 0.845 |
SIK |
0.816 | -0.017 | -3 | 0.778 |
HRI |
0.816 | -0.004 | -2 | 0.878 |
BMPR1A |
0.816 | 0.084 | 1 | 0.819 |
PKCH |
0.815 | -0.013 | 2 | 0.724 |
PAK2 |
0.815 | -0.009 | -2 | 0.762 |
PIM2 |
0.815 | 0.048 | -3 | 0.756 |
AURA |
0.815 | 0.030 | -2 | 0.633 |
AKT2 |
0.815 | 0.033 | -3 | 0.700 |
P38A |
0.815 | 0.033 | 1 | 0.660 |
CDK5 |
0.814 | -0.002 | 1 | 0.642 |
TLK2 |
0.814 | -0.051 | 1 | 0.821 |
NEK5 |
0.813 | 0.031 | 1 | 0.849 |
MSK1 |
0.813 | 0.013 | -3 | 0.773 |
MNK1 |
0.813 | -0.027 | -2 | 0.798 |
PLK3 |
0.813 | -0.039 | 2 | 0.777 |
JNK2 |
0.812 | 0.025 | 1 | 0.552 |
JNK3 |
0.812 | 0.006 | 1 | 0.597 |
CAMK2A |
0.811 | -0.054 | 2 | 0.792 |
CDK13 |
0.811 | -0.031 | 1 | 0.590 |
PINK1 |
0.811 | -0.037 | 1 | 0.828 |
IRAK4 |
0.811 | -0.010 | 1 | 0.825 |
MARK3 |
0.810 | -0.022 | 4 | 0.816 |
WNK4 |
0.810 | -0.032 | -2 | 0.884 |
MARK2 |
0.810 | -0.023 | 4 | 0.776 |
PRP4 |
0.810 | 0.028 | -3 | 0.818 |
CHK1 |
0.810 | -0.048 | -3 | 0.829 |
ERK1 |
0.810 | 0.012 | 1 | 0.567 |
BRSK1 |
0.809 | -0.034 | -3 | 0.819 |
CLK2 |
0.809 | 0.038 | -3 | 0.770 |
PRKX |
0.809 | 0.023 | -3 | 0.683 |
DCAMKL1 |
0.809 | -0.021 | -3 | 0.801 |
DNAPK |
0.809 | -0.029 | 1 | 0.698 |
CDK18 |
0.808 | -0.023 | 1 | 0.539 |
HIPK1 |
0.808 | 0.007 | 1 | 0.674 |
MPSK1 |
0.808 | 0.034 | 1 | 0.812 |
P38B |
0.808 | 0.023 | 1 | 0.580 |
CDK1 |
0.808 | -0.027 | 1 | 0.564 |
BRSK2 |
0.808 | -0.057 | -3 | 0.832 |
AKT1 |
0.808 | 0.045 | -3 | 0.716 |
MST3 |
0.807 | 0.018 | 2 | 0.834 |
PLK4 |
0.807 | -0.072 | 2 | 0.629 |
MEKK1 |
0.807 | -0.094 | 1 | 0.823 |
DRAK1 |
0.807 | -0.041 | 1 | 0.753 |
BRAF |
0.806 | -0.111 | -4 | 0.760 |
ERK7 |
0.806 | 0.092 | 2 | 0.590 |
TAO3 |
0.806 | -0.036 | 1 | 0.794 |
MAPKAPK5 |
0.806 | -0.044 | -3 | 0.752 |
ERK2 |
0.806 | -0.004 | 1 | 0.613 |
P38G |
0.805 | -0.004 | 1 | 0.472 |
HIPK2 |
0.805 | -0.000 | 1 | 0.560 |
PKCT |
0.805 | -0.016 | 2 | 0.728 |
MEKK2 |
0.805 | -0.053 | 2 | 0.790 |
SNRK |
0.805 | -0.090 | 2 | 0.663 |
ZAK |
0.805 | -0.103 | 1 | 0.795 |
TTBK1 |
0.804 | -0.015 | 2 | 0.658 |
MEK5 |
0.804 | -0.130 | 2 | 0.806 |
MARK1 |
0.804 | -0.049 | 4 | 0.836 |
SMMLCK |
0.804 | 0.001 | -3 | 0.839 |
CDK12 |
0.804 | -0.034 | 1 | 0.557 |
HIPK3 |
0.803 | 0.000 | 1 | 0.673 |
CAMKK1 |
0.803 | -0.026 | -2 | 0.771 |
PKACA |
0.803 | 0.027 | -2 | 0.629 |
CAMK1G |
0.803 | -0.047 | -3 | 0.777 |
DYRK1A |
0.803 | -0.005 | 1 | 0.696 |
TLK1 |
0.803 | -0.069 | -2 | 0.862 |
P70S6K |
0.803 | 0.010 | -3 | 0.722 |
CDK9 |
0.803 | -0.041 | 1 | 0.595 |
CDK2 |
0.802 | -0.036 | 1 | 0.652 |
TAO2 |
0.802 | 0.007 | 2 | 0.843 |
GRK2 |
0.802 | -0.073 | -2 | 0.739 |
MEKK3 |
0.802 | -0.126 | 1 | 0.803 |
LKB1 |
0.802 | -0.028 | -3 | 0.882 |
P38D |
0.801 | 0.017 | 1 | 0.503 |
SSTK |
0.801 | -0.020 | 4 | 0.846 |
NEK8 |
0.801 | -0.035 | 2 | 0.812 |
CDK17 |
0.800 | -0.038 | 1 | 0.478 |
DAPK3 |
0.799 | 0.027 | -3 | 0.817 |
PKCI |
0.799 | -0.021 | 2 | 0.754 |
DCAMKL2 |
0.799 | -0.037 | -3 | 0.816 |
PHKG2 |
0.799 | -0.032 | -3 | 0.799 |
CDK14 |
0.799 | -0.008 | 1 | 0.580 |
PAK5 |
0.799 | 0.010 | -2 | 0.630 |
CAMKK2 |
0.799 | -0.046 | -2 | 0.766 |
DYRK3 |
0.798 | 0.009 | 1 | 0.681 |
IRAK1 |
0.798 | -0.125 | -1 | 0.528 |
TNIK |
0.798 | 0.026 | 3 | 0.869 |
EEF2K |
0.798 | 0.031 | 3 | 0.836 |
CK1E |
0.797 | -0.047 | -3 | 0.535 |
GAK |
0.797 | -0.012 | 1 | 0.852 |
CAMK1D |
0.797 | -0.014 | -3 | 0.708 |
MRCKB |
0.797 | 0.070 | -3 | 0.748 |
PKCE |
0.797 | 0.011 | 2 | 0.732 |
CDK3 |
0.797 | -0.005 | 1 | 0.501 |
DYRK4 |
0.797 | -0.009 | 1 | 0.570 |
TAK1 |
0.797 | 0.077 | 1 | 0.855 |
LOK |
0.796 | 0.034 | -2 | 0.774 |
PASK |
0.796 | -0.078 | -3 | 0.887 |
HGK |
0.796 | 0.010 | 3 | 0.861 |
NEK4 |
0.796 | -0.032 | 1 | 0.799 |
CK2A2 |
0.796 | 0.036 | 1 | 0.773 |
MINK |
0.795 | 0.001 | 1 | 0.792 |
PAK4 |
0.795 | 0.011 | -2 | 0.638 |
DYRK1B |
0.795 | -0.023 | 1 | 0.587 |
VRK1 |
0.795 | 0.062 | 2 | 0.835 |
CDK16 |
0.795 | -0.019 | 1 | 0.501 |
NEK1 |
0.795 | 0.018 | 1 | 0.821 |
AKT3 |
0.795 | 0.035 | -3 | 0.644 |
MST2 |
0.794 | -0.046 | 1 | 0.805 |
MRCKA |
0.794 | 0.059 | -3 | 0.767 |
ROCK2 |
0.794 | 0.053 | -3 | 0.798 |
GCK |
0.794 | -0.030 | 1 | 0.787 |
CDK10 |
0.793 | -0.007 | 1 | 0.565 |
BUB1 |
0.793 | 0.092 | -5 | 0.734 |
NEK11 |
0.793 | -0.130 | 1 | 0.785 |
PDK1 |
0.792 | -0.058 | 1 | 0.802 |
DAPK1 |
0.792 | 0.019 | -3 | 0.800 |
MEKK6 |
0.791 | -0.062 | 1 | 0.815 |
SGK1 |
0.791 | 0.030 | -3 | 0.623 |
MAK |
0.790 | 0.039 | -2 | 0.746 |
LRRK2 |
0.790 | -0.073 | 2 | 0.844 |
MAP3K15 |
0.790 | -0.073 | 1 | 0.776 |
PKN1 |
0.790 | 0.003 | -3 | 0.734 |
CDK6 |
0.789 | 0.006 | 1 | 0.562 |
CK1G1 |
0.789 | -0.057 | -3 | 0.557 |
GRK3 |
0.789 | -0.064 | -2 | 0.701 |
HPK1 |
0.789 | -0.004 | 1 | 0.760 |
PBK |
0.788 | 0.011 | 1 | 0.782 |
SLK |
0.788 | -0.041 | -2 | 0.719 |
CK1D |
0.788 | -0.044 | -3 | 0.481 |
CHK2 |
0.788 | 0.016 | -3 | 0.644 |
MST1 |
0.787 | -0.058 | 1 | 0.787 |
CAMK1A |
0.787 | 0.004 | -3 | 0.674 |
MOK |
0.787 | 0.034 | 1 | 0.707 |
KHS1 |
0.787 | -0.002 | 1 | 0.770 |
GSK3B |
0.787 | -0.053 | 4 | 0.406 |
KHS2 |
0.787 | 0.020 | 1 | 0.775 |
CDK4 |
0.786 | 0.003 | 1 | 0.544 |
JNK1 |
0.786 | -0.015 | 1 | 0.539 |
YSK1 |
0.786 | -0.016 | 2 | 0.804 |
MEK2 |
0.785 | -0.038 | 2 | 0.790 |
PLK2 |
0.785 | -0.046 | -3 | 0.837 |
CK2A1 |
0.784 | 0.023 | 1 | 0.745 |
PKG1 |
0.783 | 0.031 | -2 | 0.603 |
NEK3 |
0.783 | -0.041 | 1 | 0.775 |
GSK3A |
0.783 | -0.055 | 4 | 0.412 |
DMPK1 |
0.782 | 0.032 | -3 | 0.763 |
TTK |
0.782 | 0.033 | -2 | 0.865 |
CK1A2 |
0.782 | -0.060 | -3 | 0.478 |
ROCK1 |
0.782 | 0.045 | -3 | 0.761 |
PDHK3_TYR |
0.782 | 0.062 | 4 | 0.906 |
STK33 |
0.780 | -0.110 | 2 | 0.637 |
RIPK2 |
0.778 | -0.119 | 1 | 0.748 |
OSR1 |
0.778 | -0.033 | 2 | 0.787 |
MYO3B |
0.777 | 0.021 | 2 | 0.816 |
TXK |
0.777 | 0.241 | 1 | 0.872 |
SBK |
0.776 | -0.002 | -3 | 0.578 |
ABL2 |
0.775 | 0.131 | -1 | 0.582 |
BIKE |
0.775 | 0.043 | 1 | 0.724 |
CRIK |
0.774 | 0.026 | -3 | 0.714 |
EPHB4 |
0.774 | 0.142 | -1 | 0.599 |
TAO1 |
0.773 | -0.018 | 1 | 0.727 |
HASPIN |
0.773 | -0.062 | -1 | 0.439 |
TYRO3 |
0.773 | 0.173 | 3 | 0.794 |
TESK1_TYR |
0.773 | -0.080 | 3 | 0.875 |
MAP2K4_TYR |
0.772 | -0.048 | -1 | 0.593 |
EPHA6 |
0.772 | 0.064 | -1 | 0.563 |
ABL1 |
0.770 | 0.118 | -1 | 0.580 |
PDHK4_TYR |
0.770 | -0.068 | 2 | 0.851 |
PKMYT1_TYR |
0.770 | -0.108 | 3 | 0.839 |
TEC |
0.770 | 0.229 | -1 | 0.616 |
LIMK2_TYR |
0.769 | -0.001 | -3 | 0.910 |
MAP2K7_TYR |
0.769 | -0.130 | 2 | 0.838 |
MAP2K6_TYR |
0.769 | -0.104 | -1 | 0.582 |
ITK |
0.769 | 0.159 | -1 | 0.598 |
LCK |
0.768 | 0.141 | -1 | 0.575 |
TNK2 |
0.768 | 0.146 | 3 | 0.745 |
MYO3A |
0.768 | -0.036 | 1 | 0.780 |
ALPHAK3 |
0.768 | -0.065 | -1 | 0.507 |
RET |
0.768 | -0.006 | 1 | 0.816 |
BLK |
0.767 | 0.144 | -1 | 0.577 |
BMX |
0.767 | 0.153 | -1 | 0.582 |
BMPR2_TYR |
0.767 | -0.104 | -1 | 0.548 |
HCK |
0.766 | 0.142 | -1 | 0.595 |
ROS1 |
0.766 | 0.042 | 3 | 0.765 |
MST1R |
0.766 | 0.009 | 3 | 0.805 |
YES1 |
0.766 | 0.100 | -1 | 0.606 |
ASK1 |
0.766 | -0.093 | 1 | 0.766 |
MERTK |
0.766 | 0.214 | 3 | 0.757 |
SRMS |
0.765 | 0.137 | 1 | 0.882 |
PDHK1_TYR |
0.765 | -0.118 | -1 | 0.581 |
PINK1_TYR |
0.765 | -0.175 | 1 | 0.858 |
BTK |
0.764 | 0.219 | -1 | 0.630 |
TYK2 |
0.763 | -0.062 | 1 | 0.819 |
LIMK1_TYR |
0.763 | -0.123 | 2 | 0.838 |
FER |
0.763 | 0.017 | 1 | 0.906 |
EPHB2 |
0.762 | 0.110 | -1 | 0.586 |
EPHB1 |
0.762 | 0.109 | 1 | 0.871 |
EPHB3 |
0.762 | 0.105 | -1 | 0.596 |
CSF1R |
0.762 | -0.003 | 3 | 0.783 |
AXL |
0.762 | 0.127 | 3 | 0.761 |
FGR |
0.760 | -0.019 | 1 | 0.876 |
JAK2 |
0.759 | -0.060 | 1 | 0.813 |
EPHA4 |
0.759 | 0.028 | 2 | 0.779 |
DDR1 |
0.758 | -0.087 | 4 | 0.830 |
TNNI3K_TYR |
0.758 | -0.012 | 1 | 0.845 |
AAK1 |
0.757 | 0.052 | 1 | 0.613 |
STLK3 |
0.756 | -0.091 | 1 | 0.755 |
WEE1_TYR |
0.755 | 0.010 | -1 | 0.547 |
YANK3 |
0.754 | -0.070 | 2 | 0.447 |
PDGFRB |
0.754 | -0.078 | 3 | 0.799 |
FLT3 |
0.754 | -0.037 | 3 | 0.787 |
JAK1 |
0.754 | 0.006 | 1 | 0.752 |
PTK2B |
0.754 | 0.104 | -1 | 0.595 |
PTK6 |
0.754 | -0.006 | -1 | 0.543 |
LTK |
0.754 | 0.057 | 3 | 0.725 |
FRK |
0.753 | 0.117 | -1 | 0.628 |
TNK1 |
0.753 | -0.045 | 3 | 0.770 |
JAK3 |
0.753 | -0.138 | 1 | 0.805 |
LYN |
0.753 | 0.084 | 3 | 0.700 |
INSRR |
0.753 | -0.093 | 3 | 0.729 |
EPHA7 |
0.753 | 0.075 | 2 | 0.782 |
EPHA1 |
0.753 | 0.131 | 3 | 0.751 |
TEK |
0.752 | 0.024 | 3 | 0.715 |
FYN |
0.752 | 0.042 | -1 | 0.538 |
ALK |
0.751 | 0.007 | 3 | 0.709 |
NEK10_TYR |
0.751 | -0.032 | 1 | 0.689 |
KIT |
0.751 | -0.085 | 3 | 0.780 |
MET |
0.751 | -0.054 | 3 | 0.775 |
KDR |
0.749 | -0.090 | 3 | 0.738 |
PDGFRA |
0.748 | -0.077 | 3 | 0.801 |
EPHA3 |
0.747 | -0.003 | 2 | 0.751 |
FGFR2 |
0.747 | -0.128 | 3 | 0.769 |
FGFR1 |
0.746 | -0.117 | 3 | 0.750 |
EPHA5 |
0.744 | 0.030 | 2 | 0.755 |
CK1A |
0.743 | -0.084 | -3 | 0.393 |
NTRK2 |
0.743 | -0.074 | 3 | 0.746 |
NTRK1 |
0.742 | -0.119 | -1 | 0.561 |
MATK |
0.741 | -0.079 | -1 | 0.504 |
ERBB2 |
0.740 | -0.104 | 1 | 0.771 |
SRC |
0.740 | -0.005 | -1 | 0.548 |
EPHA8 |
0.739 | -0.023 | -1 | 0.545 |
NTRK3 |
0.739 | -0.085 | -1 | 0.537 |
INSR |
0.738 | -0.118 | 3 | 0.706 |
DDR2 |
0.738 | -0.051 | 3 | 0.713 |
FLT1 |
0.737 | -0.157 | -1 | 0.512 |
FGFR3 |
0.736 | -0.134 | 3 | 0.737 |
EGFR |
0.734 | -0.071 | 1 | 0.683 |
FLT4 |
0.734 | -0.175 | 3 | 0.723 |
MUSK |
0.732 | -0.047 | 1 | 0.666 |
CSK |
0.732 | -0.095 | 2 | 0.788 |
PTK2 |
0.731 | -0.060 | -1 | 0.461 |
SYK |
0.731 | -0.051 | -1 | 0.471 |
EPHA2 |
0.730 | -0.023 | -1 | 0.528 |
FGFR4 |
0.729 | -0.090 | -1 | 0.518 |
CK1G3 |
0.729 | -0.063 | -3 | 0.350 |
FES |
0.721 | -0.023 | -1 | 0.536 |
YANK2 |
0.721 | -0.090 | 2 | 0.461 |
IGF1R |
0.720 | -0.143 | 3 | 0.639 |
ERBB4 |
0.719 | -0.072 | 1 | 0.694 |
ZAP70 |
0.709 | -0.080 | -1 | 0.437 |
CK1G2 |
0.703 | -0.096 | -3 | 0.460 |