Motif 399 (n=167)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| E7EW31 | PROB1 | S472 | ochoa | Proline-rich basic protein 1 | None |
| E7EWF7 | None | S95 | ochoa | Uncharacterized protein | None |
| O00750 | PIK3C2B | S179 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}. |
| O14686 | KMT2D | S3622 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14733 | MAP2K7 | S57 | ochoa | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O14983 | ATP2A1 | S338 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O43166 | SIPA1L1 | S1257 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43182 | ARHGAP6 | S115 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43847 | NRDC | S108 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60256 | PRPSAP2 | S240 | ochoa | Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41) | Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. |
| O60315 | ZEB2 | S707 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O60318 | MCM3AP | S432 | ochoa | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}. |
| O60890 | OPHN1 | S654 | ochoa | Oligophrenin-1 | Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). {ECO:0000250}. |
| O75151 | PHF2 | S879 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75420 | GIGYF1 | S865 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O75460 | ERN1 | S551 | ochoa | Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:21317875, PubMed:24508390). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:21317875, PubMed:24508390). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). {ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:19328063, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:30118681, ECO:0000269|PubMed:36739529, ECO:0000269|PubMed:9637683, ECO:0000305|PubMed:24508390}. |
| O94855 | SEC24D | S828 | ochoa | Protein transport protein Sec24D (SEC24-related protein D) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O94916 | NFAT5 | S1247 | psp | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O94985 | CLSTN1 | S436 | ochoa | Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:21385839). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:12972431). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000250|UniProtKB:Q9EPL2, ECO:0000269|PubMed:12972431, ECO:0000269|PubMed:21385839}.; FUNCTION: [Soluble Alc-alpha]: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding (PubMed:15037614). {ECO:0000305|PubMed:15037614}.; FUNCTION: [CTF1-alpha]: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP (PubMed:15037614). {ECO:0000305|PubMed:15037614}. |
| O95210 | STBD1 | S104 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95235 | KIF20A | S534 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95453 | PARN | S572 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| O95490 | ADGRL2 | Y1383 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| P02724 | GYPA | S123 | ochoa | Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:15331714}.; FUNCTION: (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. {ECO:0000269|PubMed:8009226}. |
| P04198 | MYCN | S64 | ochoa | N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37) | Positively regulates the transcription of MYCNOS in neuroblastoma cells. {ECO:0000269|PubMed:24391509}. |
| P05455 | SSB | S94 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P09874 | PARP1 | S274 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P10244 | MYBL2 | S395 | ochoa | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P16615 | ATP2A2 | S338 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P18583 | SON | S1648 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P25054 | APC | S1044 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27987 | ITPKB | S564 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P31629 | HIVEP2 | S1072 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P35612 | ADD2 | S532 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P35711 | SOX5 | Y23 | ochoa | Transcription factor SOX-5 | Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}. |
| P49796 | RGS3 | S730 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P50748 | KNTC1 | S1047 | ochoa | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| P50851 | LRBA | S1086 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51617 | IRAK1 | S373 | ochoa | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| P52888 | THOP1 | S91 | ochoa | Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}. |
| P53004 | BLVRA | S237 | ochoa|psp | Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}. |
| P53992 | SEC24C | S890 | ochoa | Protein transport protein Sec24C (SEC24-related protein C) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| P54198 | HIRA | S551 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P78314 | SH3BP2 | S427 | ochoa | SH3 domain-binding protein 2 (3BP-2) | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. |
| P78364 | PHC1 | S788 | ochoa | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. {ECO:0000269|PubMed:23418308}. |
| P98171 | ARHGAP4 | S410 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q00403 | GTF2B | S65 | psp | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
| Q03188 | CENPC | S75 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q09666 | AHNAK | S379 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4908 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5261 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q10570 | CPSF1 | S758 | ochoa | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}. |
| Q12774 | ARHGEF5 | S452 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12959 | DLG1 | S104 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q13393 | PLD1 | S47 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13425 | SNTB2 | S395 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
| Q13554 | CAMK2B | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13555 | CAMK2G | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13557 | CAMK2D | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q14203 | DCTN1 | S1182 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14515 | SPARCL1 | S92 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
| Q14684 | RRP1B | S422 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14694 | USP10 | S549 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14699 | RFTN1 | S241 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q15596 | NCOA2 | S1074 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q2KHT3 | CLEC16A | S982 | ochoa | Protein CLEC16A (C-type lectin domain family 16 member A) | Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. {ECO:0000269|PubMed:24949970}. |
| Q2KJY2 | KIF26B | S1042 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q3KQU3 | MAP7D1 | S282 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3KR16 | PLEKHG6 | S546 | ochoa | Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) | Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}. |
| Q5BKX5 | ACTMAP | S318 | ochoa | Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) | Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}. |
| Q5M775 | SPECC1 | S914 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T0W9 | FAM83B | S854 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5TBA9 | FRY | S1382 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5VT06 | CEP350 | S1504 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT06 | CEP350 | S2484 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT52 | RPRD2 | S667 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUA4 | ZNF318 | S143 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VWN6 | TASOR2 | S221 | ochoa | Protein TASOR 2 | None |
| Q5VWN6 | TASOR2 | S1174 | ochoa | Protein TASOR 2 | None |
| Q5XUX1 | FBXW9 | S61 | ochoa | F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. |
| Q6AI08 | HEATR6 | S635 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6FI81 | CIAPIN1 | S185 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q6NZY4 | ZCCHC8 | S651 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6P2E9 | EDC4 | S30 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6T4R5 | NHS | S1178 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q76L83 | ASXL2 | S397 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7RTP6 | MICAL3 | S1175 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z401 | DENND4A | S1511 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z6Z7 | HUWE1 | S2372 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86U44 | METTL3 | S350 | ochoa|psp | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86YS7 | C2CD5 | S262 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q8IY92 | SLX4 | S201 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IY92 | SLX4 | S1204 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYB5 | SMAP1 | S154 | ochoa | Stromal membrane-associated protein 1 | GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). {ECO:0000250}. |
| Q8N1F7 | NUP93 | S769 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N5C8 | TAB3 | S82 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8NDX1 | PSD4 | S1022 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEM0 | MCPH1 | S279 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NEY1 | NAV1 | S654 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFC6 | BOD1L1 | S1283 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TAA9 | VANGL1 | S88 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TB45 | DEPTOR | S267 | ochoa|psp | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8TCN5 | ZNF507 | S197 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TDB6 | DTX3L | S204 | ochoa | E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) | E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}. |
| Q8WUY3 | PRUNE2 | S622 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q92576 | PHF3 | S1724 | ochoa | PHD finger protein 3 | None |
| Q92628 | KIAA0232 | S158 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q92733 | PRCC | S243 | ochoa | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q93084 | ATP2A3 | S338 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Q969E2 | SCAMP4 | S200 | ochoa | Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4) | Probably involved in membrane protein trafficking. {ECO:0000250}. |
| Q969I6 | SLC38A4 | S19 | ochoa | Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) | Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:19015196, ECO:0000269|PubMed:33928121}. |
| Q96B01 | RAD51AP1 | S296 | ochoa | RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) | Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). {ECO:0000269|PubMed:17996710, ECO:0000269|PubMed:17996711, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22375013, ECO:0000269|PubMed:25288561, ECO:0000269|PubMed:26323318, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31400850, ECO:0000269|PubMed:32350107, ECO:0000269|PubMed:9396801}. |
| Q96CB9 | NSUN4 | S208 | ochoa | 5-cytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (5-cytosine tRNA methyltransferase NSUN4) (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) (mRNA cytosine C(5)-methyltransferase NSUN4) (EC 2.1.1.-) | Mitochondrial RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as rRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:21531335, PubMed:23022348, PubMed:39019044). Involved in mitochondrial ribosome small subunit (SSU) maturation by catalyzing methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU) (PubMed:21531335, PubMed:23022348). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled (PubMed:21531335, PubMed:23022348). In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4 (PubMed:23022348). Also acts as a regulator of innate immunity by marking double-stranded mitochondrial RNAs(mt-dsRNAs) generated in response to stress: catalyzes m5C modification on mitochondrial RNAs, such as a mRNAs and lncRNAs, with a preference for the termini of light-strand lncRNAs, promoting their degradation and cytosolic release (PubMed:39019044). Modified light-strand lncRNAs are then recognized by C1QBP reader and recruited to the mitochondrial degradosome complex, which promotes their degradation (PubMed:39019044). {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:23022348, ECO:0000269|PubMed:39019044}. |
| Q96DZ5 | CLIP3 | S404 | ochoa | CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) | Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269|PubMed:19139280}. |
| Q96E17 | RAB3C | S198 | ochoa | Ras-related protein Rab-3C (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P10949}. |
| Q96H79 | ZC3HAV1L | S259 | ochoa | Zinc finger CCCH-type antiviral protein 1-like | None |
| Q96N67 | DOCK7 | S948 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96NY9 | MUS81 | S97 | ochoa | Structure-specific endonuclease subunit MUS81 (EC 3.1.22.-) (Crossover junction endonuclease MUS81) (MUS81 endonuclease homolog) | Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability (PubMed:11741546, PubMed:12374758, PubMed:12686547, PubMed:12721304, PubMed:24371268, PubMed:24733841, PubMed:24813886, PubMed:35290797, PubMed:39015284). Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs (PubMed:24371268, PubMed:24733841, PubMed:35290797). MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing (PubMed:24813886). Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork (PubMed:24813886). MUS81-EME2 could also function in telomere maintenance (PubMed:24813886). MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination (PubMed:11741546, PubMed:12374758, PubMed:14617801, PubMed:15805243, PubMed:24813886). {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:24371268, ECO:0000269|PubMed:24733841, ECO:0000269|PubMed:24813886, ECO:0000269|PubMed:35290797, ECO:0000269|PubMed:39015284}. |
| Q96RT1 | ERBIN | S662 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96T58 | SPEN | S1263 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99081 | TCF12 | S388 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99569 | PKP4 | S512 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99624 | SLC38A3 | S54 | ochoa | Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) | Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10823827). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10823827}. |
| Q99741 | CDC6 | S108 | ochoa | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q9BPZ7 | MAPKAP1 | S449 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BR61 | ACBD6 | S108 | ochoa | Acyl-CoA-binding domain-containing protein 6 | Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. Plays a role in protein N-myristoylation (PubMed:37951597). {ECO:0000269|PubMed:18268358, ECO:0000269|PubMed:37951597}. |
| Q9BYV8 | CEP41 | S121 | ochoa | Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) | Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. {ECO:0000269|PubMed:22246503}. |
| Q9H3D4 | TP63 | S457 | ochoa | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q9H706 | GAREM1 | S616 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
| Q9H7N4 | SCAF1 | S32 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H7U1 | CCSER2 | Y627 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H8V3 | ECT2 | S406 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9H8V3 | ECT2 | S891 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NPI1 | BRD7 | S291 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NRR4 | DROSHA | S357 | ochoa | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q9NRW4 | DUSP22 | S60 | ochoa | Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK pathway associated phosphatase) (JKAP) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed:24714587, PubMed:38225265). Activates the JNK signaling pathway (PubMed:11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed:24714587, PubMed:38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed:38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed:24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed:38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity). {ECO:0000250|UniProtKB:Q99N11, ECO:0000269|PubMed:11717427, ECO:0000269|PubMed:24714587, ECO:0000269|PubMed:38225265}. |
| Q9NVI7 | ATAD3A | S371 | ochoa | ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:17210950, PubMed:20154147, PubMed:22453275, PubMed:31522117, PubMed:37832546, PubMed:39116259). May play an important role in mitochondrial protein synthesis (PubMed:22453275). May also participate in mitochondrial DNA replication (PubMed:17210950). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (PubMed:17210950). Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (PubMed:22453275). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress (PubMed:39116259). Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity (PubMed:39116259). Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR) (PubMed:37832546). {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:39116259}. |
| Q9NW97 | TMEM51 | S160 | ochoa | Transmembrane protein 51 | None |
| Q9NWQ4 | GPATCH2L | S449 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NYI0 | PSD3 | S1014 | ochoa | PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) | Guanine nucleotide exchange factor for ARF6. {ECO:0000250}. |
| Q9NZN5 | ARHGEF12 | S343 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9UBB5 | MBD2 | S183 | ochoa | Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| Q9UGJ0 | PRKAG2 | S164 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
| Q9UJF2 | RASAL2 | S665 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UK61 | TASOR | S1195 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UPP1 | PHF8 | S854 | ochoa|psp | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UPU5 | USP24 | S1143 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UQB3 | CTNND2 | S534 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9UQM7 | CAMK2A | S234 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9UQR1 | ZNF148 | S627 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y2H2 | INPP5F | S942 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y2X9 | ZNF281 | S807 | ochoa|psp | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y3L3 | SH3BP1 | S264 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y487 | ATP6V0A2 | S154 | ochoa | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}. |
| Q9Y4D2 | DAGLA | S808 | psp | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}. |
| Q9Y4G8 | RAPGEF2 | S1225 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y5S2 | CDC42BPB | S365 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y5U5 | TNFRSF18 | S211 | ochoa | Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| V9GYH0 | None | S33 | ochoa | Homeobox domain-containing protein | None |
| Q16576 | RBBP7 | S163 | Sugiyama | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| O15075 | DCLK1 | S174 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| Q12931 | TRAP1 | Y513 | Sugiyama | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| O00116 | AGPS | S176 | Sugiyama | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
| O94979 | SEC31A | S190 | Sugiyama | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| Q15751 | HERC1 | S3240 | Sugiyama | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q09028 | RBBP4 | S164 | Sugiyama | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| Q9NWS0 | PIH1D1 | S175 | Sugiyama | PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog) | Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 7.277492e-07 | 6.138 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 7.277492e-07 | 6.138 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 7.277492e-07 | 6.138 |
| R-HSA-9620244 | Long-term potentiation | 1.607085e-06 | 5.794 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.921393e-06 | 5.228 |
| R-HSA-5578775 | Ion homeostasis | 8.952120e-06 | 5.048 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.569311e-05 | 4.804 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.895611e-05 | 4.722 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.125580e-05 | 4.673 |
| R-HSA-399719 | Trafficking of AMPA receptors | 6.652141e-05 | 4.177 |
| R-HSA-1538133 | G0 and Early G1 | 7.533410e-05 | 4.123 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 8.501946e-05 | 4.070 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.137022e-04 | 3.944 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.042288e-04 | 3.517 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 6.125716e-04 | 3.213 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 6.721241e-04 | 3.173 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 9.653010e-04 | 3.015 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.015885e-03 | 2.993 |
| R-HSA-111933 | Calmodulin induced events | 1.450638e-03 | 2.838 |
| R-HSA-111997 | CaM pathway | 1.450638e-03 | 2.838 |
| R-HSA-5673000 | RAF activation | 1.219743e-03 | 2.914 |
| R-HSA-5576891 | Cardiac conduction | 1.402465e-03 | 2.853 |
| R-HSA-162582 | Signal Transduction | 1.247116e-03 | 2.904 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.529761e-03 | 2.815 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.851631e-03 | 2.732 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.869178e-03 | 2.542 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.201430e-03 | 2.495 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.283906e-03 | 2.484 |
| R-HSA-447038 | NrCAM interactions | 2.860333e-03 | 2.544 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.506838e-03 | 2.601 |
| R-HSA-111996 | Ca-dependent events | 2.497692e-03 | 2.602 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.323578e-03 | 2.634 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.073462e-03 | 2.512 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.283906e-03 | 2.484 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.283906e-03 | 2.484 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.283906e-03 | 2.484 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.559097e-03 | 2.592 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.283906e-03 | 2.484 |
| R-HSA-983712 | Ion channel transport | 2.465437e-03 | 2.608 |
| R-HSA-73887 | Death Receptor Signaling | 3.348112e-03 | 2.475 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.484352e-03 | 2.348 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 4.659992e-03 | 2.332 |
| R-HSA-381070 | IRE1alpha activates chaperones | 5.716861e-03 | 2.243 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 6.860828e-03 | 2.164 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.329418e-03 | 2.135 |
| R-HSA-418360 | Platelet calcium homeostasis | 7.262572e-03 | 2.139 |
| R-HSA-112043 | PLC beta mediated events | 7.704452e-03 | 2.113 |
| R-HSA-1640170 | Cell Cycle | 7.712129e-03 | 2.113 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.094436e-03 | 2.092 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 8.397671e-03 | 2.076 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 9.444524e-03 | 2.025 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 9.730001e-03 | 2.012 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 9.730001e-03 | 2.012 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 9.330326e-03 | 2.030 |
| R-HSA-112040 | G-protein mediated events | 1.022089e-02 | 1.991 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.041387e-02 | 1.982 |
| R-HSA-9832991 | Formation of the posterior neural plate | 1.087439e-02 | 1.964 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.087439e-02 | 1.964 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.105473e-02 | 1.956 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 1.112496e-02 | 1.954 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.165709e-02 | 1.933 |
| R-HSA-74160 | Gene expression (Transcription) | 1.218923e-02 | 1.914 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.262955e-02 | 1.899 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.399935e-02 | 1.854 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.522240e-02 | 1.818 |
| R-HSA-68886 | M Phase | 1.535194e-02 | 1.814 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.569024e-02 | 1.804 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.574495e-02 | 1.803 |
| R-HSA-397014 | Muscle contraction | 1.574495e-02 | 1.803 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.687833e-02 | 1.773 |
| R-HSA-68875 | Mitotic Prophase | 1.760462e-02 | 1.754 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.931859e-02 | 1.714 |
| R-HSA-9823739 | Formation of the anterior neural plate | 1.931859e-02 | 1.714 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.915842e-02 | 1.718 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.072550e-02 | 1.683 |
| R-HSA-3371556 | Cellular response to heat stress | 1.811292e-02 | 1.742 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.075753e-02 | 1.683 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.183261e-02 | 1.661 |
| R-HSA-774815 | Nucleosome assembly | 2.183261e-02 | 1.661 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.222459e-02 | 1.653 |
| R-HSA-2262752 | Cellular responses to stress | 2.298698e-02 | 1.639 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.307378e-02 | 1.637 |
| R-HSA-1483148 | Synthesis of PG | 2.326240e-02 | 1.633 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.589199e-02 | 1.587 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.750621e-02 | 1.561 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 2.750621e-02 | 1.561 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.826301e-02 | 1.417 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.900774e-02 | 1.409 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.726689e-02 | 1.429 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.683457e-02 | 1.434 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.093749e-02 | 1.388 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.779899e-02 | 1.423 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.826301e-02 | 1.417 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.522673e-02 | 1.453 |
| R-HSA-4839726 | Chromatin organization | 3.175768e-02 | 1.498 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.409653e-02 | 1.467 |
| R-HSA-450294 | MAP kinase activation | 4.243384e-02 | 1.372 |
| R-HSA-111885 | Opioid Signalling | 4.036565e-02 | 1.394 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.574597e-02 | 1.447 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.349502e-02 | 1.362 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.349502e-02 | 1.362 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.349502e-02 | 1.362 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.349502e-02 | 1.362 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.349502e-02 | 1.362 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.349502e-02 | 1.362 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.349502e-02 | 1.362 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.349502e-02 | 1.362 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.349502e-02 | 1.362 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.349502e-02 | 1.362 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.349502e-02 | 1.362 |
| R-HSA-9839394 | TGFBR3 expression | 4.719008e-02 | 1.326 |
| R-HSA-3214842 | HDMs demethylate histones | 4.719008e-02 | 1.326 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.032041e-02 | 1.298 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 5.407154e-02 | 1.267 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 5.407154e-02 | 1.267 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 5.846681e-02 | 1.233 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.710539e-02 | 1.243 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.197754e-02 | 1.284 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 5.556678e-02 | 1.255 |
| R-HSA-5694530 | Cargo concentration in the ER | 6.441949e-02 | 1.191 |
| R-HSA-5693538 | Homology Directed Repair | 6.083944e-02 | 1.216 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.804720e-02 | 1.167 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.563674e-02 | 1.183 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.443265e-02 | 1.191 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.443265e-02 | 1.191 |
| R-HSA-448424 | Interleukin-17 signaling | 5.710539e-02 | 1.243 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.246381e-02 | 1.204 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.389313e-02 | 1.268 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.189151e-02 | 1.143 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.189151e-02 | 1.143 |
| R-HSA-2559583 | Cellular Senescence | 7.259242e-02 | 1.139 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.384959e-02 | 1.132 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 7.689496e-02 | 1.114 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 7.689496e-02 | 1.114 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 8.012448e-02 | 1.096 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 8.510834e-02 | 1.070 |
| R-HSA-4839744 | Signaling by APC mutants | 1.441763e-01 | 0.841 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.441763e-01 | 0.841 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.441763e-01 | 0.841 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.441763e-01 | 0.841 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.536454e-01 | 0.813 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.630103e-01 | 0.788 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.630103e-01 | 0.788 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.630103e-01 | 0.788 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.630103e-01 | 0.788 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.630103e-01 | 0.788 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.630103e-01 | 0.788 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.630103e-01 | 0.788 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.722721e-01 | 0.764 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.904912e-01 | 0.720 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.083114e-01 | 0.681 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 8.339557e-02 | 1.079 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 9.344539e-02 | 1.029 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 9.686999e-02 | 1.014 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.343128e-01 | 0.630 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.427899e-01 | 0.615 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.427899e-01 | 0.615 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.427899e-01 | 0.615 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.427899e-01 | 0.615 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.752609e-01 | 0.756 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.871746e-01 | 0.728 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.871746e-01 | 0.728 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.991977e-01 | 0.701 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.275679e-01 | 0.643 |
| R-HSA-380287 | Centrosome maturation | 2.357310e-01 | 0.628 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.249209e-01 | 0.903 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.257414e-01 | 0.646 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.398742e-01 | 0.854 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.398742e-01 | 0.854 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.234940e-01 | 0.651 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.083114e-01 | 0.681 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.221473e-01 | 0.913 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.346019e-01 | 0.871 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.346019e-01 | 0.871 |
| R-HSA-192814 | vRNA Synthesis | 1.441763e-01 | 0.841 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.536454e-01 | 0.813 |
| R-HSA-75896 | Plasmalogen biosynthesis | 1.536454e-01 | 0.813 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.536454e-01 | 0.813 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.536454e-01 | 0.813 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.536454e-01 | 0.813 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.630103e-01 | 0.788 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.814320e-01 | 0.741 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.814320e-01 | 0.741 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.904912e-01 | 0.720 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.257414e-01 | 0.646 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 9.686999e-02 | 1.014 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.501809e-01 | 0.823 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.441904e-01 | 0.841 |
| R-HSA-9843745 | Adipogenesis | 2.250351e-01 | 0.648 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.132641e-01 | 0.946 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.052348e-01 | 0.978 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.249209e-01 | 0.903 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.346019e-01 | 0.871 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.814320e-01 | 0.741 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.557057e-01 | 0.808 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.722721e-01 | 0.764 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 9.686999e-02 | 1.014 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 9.686999e-02 | 1.014 |
| R-HSA-426048 | Arachidonate production from DAG | 1.346019e-01 | 0.871 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.083114e-01 | 0.681 |
| R-HSA-9710421 | Defective pyroptosis | 1.109096e-01 | 0.955 |
| R-HSA-68877 | Mitotic Prometaphase | 2.113646e-01 | 0.675 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 8.608598e-02 | 1.065 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.814320e-01 | 0.741 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.427899e-01 | 0.615 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.831902e-01 | 0.737 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.194260e-01 | 0.659 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.660775e-01 | 0.780 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.257414e-01 | 0.646 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.527951e-01 | 0.816 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.323909e-01 | 0.634 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.536454e-01 | 0.813 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.224592e-01 | 0.912 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.224592e-01 | 0.912 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.224592e-01 | 0.912 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.633938e-01 | 0.787 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.714839e-01 | 0.766 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.852141e-01 | 0.732 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.279439e-01 | 0.642 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.852141e-01 | 0.732 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.935881e-01 | 0.713 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.249209e-01 | 0.903 |
| R-HSA-983189 | Kinesins | 1.752609e-01 | 0.756 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.935881e-01 | 0.713 |
| R-HSA-69275 | G2/M Transition | 1.954110e-01 | 0.709 |
| R-HSA-9613354 | Lipophagy | 1.249209e-01 | 0.903 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.441763e-01 | 0.841 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.722721e-01 | 0.764 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.994506e-01 | 0.700 |
| R-HSA-8848584 | Wax and plasmalogen biosynthesis | 2.427899e-01 | 0.615 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.713176e-01 | 0.766 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.501809e-01 | 0.823 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.275679e-01 | 0.643 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.999303e-01 | 0.699 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.191589e-02 | 1.087 |
| R-HSA-69206 | G1/S Transition | 2.048971e-01 | 0.688 |
| R-HSA-112316 | Neuronal System | 1.796955e-01 | 0.745 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.986739e-02 | 1.046 |
| R-HSA-6793080 | rRNA modification in the mitochondrion | 1.722721e-01 | 0.764 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.083114e-01 | 0.681 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.073508e-01 | 0.969 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.714839e-01 | 0.766 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.407909e-01 | 0.851 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 8.510834e-02 | 1.070 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 8.670694e-02 | 1.062 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.153646e-01 | 0.667 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.244313e-01 | 0.905 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 1.181180e-01 | 0.928 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.994506e-01 | 0.700 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.254404e-01 | 0.902 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.325799e-02 | 1.030 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.554238e-01 | 0.808 |
| R-HSA-73886 | Chromosome Maintenance | 1.907861e-01 | 0.719 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.554238e-01 | 0.808 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.424278e-01 | 0.846 |
| R-HSA-418990 | Adherens junctions interactions | 1.276357e-01 | 0.894 |
| R-HSA-421270 | Cell-cell junction organization | 1.854039e-01 | 0.732 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.647493e-01 | 0.783 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.449272e-01 | 0.839 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.217655e-01 | 0.914 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.911711e-01 | 0.719 |
| R-HSA-446728 | Cell junction organization | 2.385152e-01 | 0.622 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.712049e-02 | 1.013 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.276727e-01 | 0.643 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.441698e-01 | 0.841 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.346019e-01 | 0.871 |
| R-HSA-201556 | Signaling by ALK | 9.344539e-02 | 1.029 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.948956e-01 | 0.710 |
| R-HSA-212436 | Generic Transcription Pathway | 1.558335e-01 | 0.807 |
| R-HSA-1483166 | Synthesis of PA | 1.634777e-01 | 0.787 |
| R-HSA-1280218 | Adaptive Immune System | 1.380971e-01 | 0.860 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 1.713176e-01 | 0.766 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 2.032263e-01 | 0.692 |
| R-HSA-75893 | TNF signaling | 1.595828e-01 | 0.797 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.170746e-01 | 0.663 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.144990e-01 | 0.941 |
| R-HSA-877300 | Interferon gamma signaling | 1.360469e-01 | 0.866 |
| R-HSA-418346 | Platelet homeostasis | 1.449969e-01 | 0.839 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.633938e-01 | 0.787 |
| R-HSA-6807070 | PTEN Regulation | 2.514540e-01 | 0.600 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.644005e-01 | 0.578 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.676650e-01 | 0.572 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 2.676650e-01 | 0.572 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.726019e-01 | 0.564 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.739009e-01 | 0.562 |
| R-HSA-200425 | Carnitine shuttle | 2.757748e-01 | 0.559 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.757748e-01 | 0.559 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.808003e-01 | 0.552 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.808003e-01 | 0.552 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.813043e-01 | 0.551 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.837953e-01 | 0.547 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.837953e-01 | 0.547 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.837953e-01 | 0.547 |
| R-HSA-429947 | Deadenylation of mRNA | 2.837953e-01 | 0.547 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 2.837953e-01 | 0.547 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.848971e-01 | 0.545 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.917274e-01 | 0.535 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.917274e-01 | 0.535 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.917274e-01 | 0.535 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.917274e-01 | 0.535 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.917274e-01 | 0.535 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.917274e-01 | 0.535 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.930839e-01 | 0.533 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.930839e-01 | 0.533 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.972449e-01 | 0.527 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.993738e-01 | 0.524 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.995722e-01 | 0.523 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.995722e-01 | 0.523 |
| R-HSA-525793 | Myogenesis | 2.995722e-01 | 0.523 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.012584e-01 | 0.521 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.073306e-01 | 0.512 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.073306e-01 | 0.512 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.073306e-01 | 0.512 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.073306e-01 | 0.512 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.073306e-01 | 0.512 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 3.073306e-01 | 0.512 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.150035e-01 | 0.502 |
| R-HSA-77387 | Insulin receptor recycling | 3.150035e-01 | 0.502 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.150035e-01 | 0.502 |
| R-HSA-5620971 | Pyroptosis | 3.150035e-01 | 0.502 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.175066e-01 | 0.498 |
| R-HSA-1500931 | Cell-Cell communication | 3.189872e-01 | 0.496 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.225919e-01 | 0.491 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.225919e-01 | 0.491 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.225919e-01 | 0.491 |
| R-HSA-199991 | Membrane Trafficking | 3.276671e-01 | 0.485 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.300967e-01 | 0.481 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.300967e-01 | 0.481 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.300967e-01 | 0.481 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.300967e-01 | 0.481 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.300967e-01 | 0.481 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.300967e-01 | 0.481 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.300967e-01 | 0.481 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.337681e-01 | 0.477 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.375188e-01 | 0.472 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.375188e-01 | 0.472 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.375188e-01 | 0.472 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.448591e-01 | 0.462 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.448591e-01 | 0.462 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.448591e-01 | 0.462 |
| R-HSA-3214847 | HATs acetylate histones | 3.458547e-01 | 0.461 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.498681e-01 | 0.456 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.521185e-01 | 0.453 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.521185e-01 | 0.453 |
| R-HSA-9930044 | Nuclear RNA decay | 3.521185e-01 | 0.453 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.521185e-01 | 0.453 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.521185e-01 | 0.453 |
| R-HSA-159418 | Recycling of bile acids and salts | 3.521185e-01 | 0.453 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.521185e-01 | 0.453 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.521185e-01 | 0.453 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.538732e-01 | 0.451 |
| R-HSA-1483255 | PI Metabolism | 3.578698e-01 | 0.446 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.592980e-01 | 0.445 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.592980e-01 | 0.445 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.592980e-01 | 0.445 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.592980e-01 | 0.445 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.592980e-01 | 0.445 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.592980e-01 | 0.445 |
| R-HSA-189483 | Heme degradation | 3.592980e-01 | 0.445 |
| R-HSA-5688426 | Deubiquitination | 3.656149e-01 | 0.437 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.658514e-01 | 0.437 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.663983e-01 | 0.436 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.663983e-01 | 0.436 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.663983e-01 | 0.436 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.663983e-01 | 0.436 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.663983e-01 | 0.436 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.734204e-01 | 0.428 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 3.734204e-01 | 0.428 |
| R-HSA-381042 | PERK regulates gene expression | 3.734204e-01 | 0.428 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.803651e-01 | 0.420 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.803651e-01 | 0.420 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.803651e-01 | 0.420 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.816533e-01 | 0.418 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.816533e-01 | 0.418 |
| R-HSA-211000 | Gene Silencing by RNA | 3.816533e-01 | 0.418 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.872332e-01 | 0.412 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.872332e-01 | 0.412 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.894999e-01 | 0.409 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.912625e-01 | 0.408 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.940256e-01 | 0.404 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.940256e-01 | 0.404 |
| R-HSA-8875878 | MET promotes cell motility | 3.940256e-01 | 0.404 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.007432e-01 | 0.397 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.007432e-01 | 0.397 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.007432e-01 | 0.397 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.007432e-01 | 0.397 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.011868e-01 | 0.397 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.073867e-01 | 0.390 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.073867e-01 | 0.390 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.073867e-01 | 0.390 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.073867e-01 | 0.390 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 4.073867e-01 | 0.390 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.084881e-01 | 0.389 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.136263e-01 | 0.383 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.139569e-01 | 0.383 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.139569e-01 | 0.383 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.139569e-01 | 0.383 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.139569e-01 | 0.383 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.139569e-01 | 0.383 |
| R-HSA-73894 | DNA Repair | 4.153614e-01 | 0.382 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.204286e-01 | 0.376 |
| R-HSA-167161 | HIV Transcription Initiation | 4.204547e-01 | 0.376 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.204547e-01 | 0.376 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.204547e-01 | 0.376 |
| R-HSA-373760 | L1CAM interactions | 4.242396e-01 | 0.372 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.255499e-01 | 0.371 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 4.268809e-01 | 0.370 |
| R-HSA-165159 | MTOR signalling | 4.268809e-01 | 0.370 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.280377e-01 | 0.369 |
| R-HSA-9609690 | HCMV Early Events | 4.283420e-01 | 0.368 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.332362e-01 | 0.363 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.395214e-01 | 0.357 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.400216e-01 | 0.357 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.430978e-01 | 0.354 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.457373e-01 | 0.351 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.457373e-01 | 0.351 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.518847e-01 | 0.345 |
| R-HSA-9675135 | Diseases of DNA repair | 4.518847e-01 | 0.345 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.518847e-01 | 0.345 |
| R-HSA-75153 | Apoptotic execution phase | 4.518847e-01 | 0.345 |
| R-HSA-9679506 | SARS-CoV Infections | 4.592692e-01 | 0.338 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.616126e-01 | 0.336 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.616126e-01 | 0.336 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.616126e-01 | 0.336 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.639767e-01 | 0.334 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.639767e-01 | 0.334 |
| R-HSA-1483257 | Phospholipid metabolism | 4.647630e-01 | 0.333 |
| R-HSA-913531 | Interferon Signaling | 4.673395e-01 | 0.330 |
| R-HSA-73893 | DNA Damage Bypass | 4.699228e-01 | 0.328 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.758034e-01 | 0.323 |
| R-HSA-9864848 | Complex IV assembly | 4.816191e-01 | 0.317 |
| R-HSA-72187 | mRNA 3'-end processing | 4.873706e-01 | 0.312 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.873706e-01 | 0.312 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.873706e-01 | 0.312 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.873706e-01 | 0.312 |
| R-HSA-68882 | Mitotic Anaphase | 4.885682e-01 | 0.311 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.913623e-01 | 0.309 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.986839e-01 | 0.302 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.042472e-01 | 0.297 |
| R-HSA-177929 | Signaling by EGFR | 5.097490e-01 | 0.293 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.097490e-01 | 0.293 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.097490e-01 | 0.293 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.151901e-01 | 0.288 |
| R-HSA-418594 | G alpha (i) signalling events | 5.178720e-01 | 0.286 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.205711e-01 | 0.284 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.240053e-01 | 0.281 |
| R-HSA-388396 | GPCR downstream signalling | 5.255542e-01 | 0.279 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.258928e-01 | 0.279 |
| R-HSA-191859 | snRNP Assembly | 5.258928e-01 | 0.279 |
| R-HSA-9033241 | Peroxisomal protein import | 5.258928e-01 | 0.279 |
| R-HSA-8873719 | RAB geranylgeranylation | 5.311557e-01 | 0.275 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.311557e-01 | 0.275 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.319184e-01 | 0.274 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.363605e-01 | 0.271 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.363605e-01 | 0.271 |
| R-HSA-211976 | Endogenous sterols | 5.363605e-01 | 0.271 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.415078e-01 | 0.266 |
| R-HSA-9707616 | Heme signaling | 5.415078e-01 | 0.266 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.415078e-01 | 0.266 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.465983e-01 | 0.262 |
| R-HSA-373755 | Semaphorin interactions | 5.465983e-01 | 0.262 |
| R-HSA-69242 | S Phase | 5.517665e-01 | 0.258 |
| R-HSA-157118 | Signaling by NOTCH | 5.534352e-01 | 0.257 |
| R-HSA-9758941 | Gastrulation | 5.550168e-01 | 0.256 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.582505e-01 | 0.253 |
| R-HSA-382551 | Transport of small molecules | 5.608283e-01 | 0.251 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.646680e-01 | 0.248 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.664045e-01 | 0.247 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.712200e-01 | 0.243 |
| R-HSA-167172 | Transcription of the HIV genome | 5.712200e-01 | 0.243 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.712200e-01 | 0.243 |
| R-HSA-5218859 | Regulated Necrosis | 5.712200e-01 | 0.243 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.741691e-01 | 0.241 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.764724e-01 | 0.239 |
| R-HSA-9609646 | HCMV Infection | 5.789988e-01 | 0.237 |
| R-HSA-162587 | HIV Life Cycle | 5.804194e-01 | 0.236 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.806922e-01 | 0.236 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.806922e-01 | 0.236 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.853500e-01 | 0.233 |
| R-HSA-189445 | Metabolism of porphyrins | 5.853500e-01 | 0.233 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.899563e-01 | 0.229 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.899563e-01 | 0.229 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.899563e-01 | 0.229 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.899563e-01 | 0.229 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.945118e-01 | 0.226 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.945118e-01 | 0.226 |
| R-HSA-4086398 | Ca2+ pathway | 5.945118e-01 | 0.226 |
| R-HSA-109581 | Apoptosis | 5.957514e-01 | 0.225 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.987816e-01 | 0.223 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.990169e-01 | 0.223 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 5.990169e-01 | 0.223 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.017665e-01 | 0.221 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.034722e-01 | 0.219 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.034722e-01 | 0.219 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.034722e-01 | 0.219 |
| R-HSA-917937 | Iron uptake and transport | 6.034722e-01 | 0.219 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 6.034722e-01 | 0.219 |
| R-HSA-5689603 | UCH proteinases | 6.078783e-01 | 0.216 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.108361e-01 | 0.214 |
| R-HSA-168256 | Immune System | 6.123773e-01 | 0.213 |
| R-HSA-72306 | tRNA processing | 6.222900e-01 | 0.206 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.226486e-01 | 0.206 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.250211e-01 | 0.204 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.250211e-01 | 0.204 |
| R-HSA-6806834 | Signaling by MET | 6.250211e-01 | 0.204 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.250211e-01 | 0.204 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.291890e-01 | 0.201 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.308343e-01 | 0.200 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.336489e-01 | 0.198 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.373872e-01 | 0.196 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.414184e-01 | 0.193 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.414184e-01 | 0.193 |
| R-HSA-611105 | Respiratory electron transport | 6.447410e-01 | 0.191 |
| R-HSA-372790 | Signaling by GPCR | 6.453353e-01 | 0.190 |
| R-HSA-168255 | Influenza Infection | 6.474725e-01 | 0.189 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.493477e-01 | 0.188 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.493477e-01 | 0.188 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.532467e-01 | 0.185 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.571026e-01 | 0.182 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.582333e-01 | 0.182 |
| R-HSA-9663891 | Selective autophagy | 6.609158e-01 | 0.180 |
| R-HSA-73884 | Base Excision Repair | 6.684163e-01 | 0.175 |
| R-HSA-109582 | Hemostasis | 6.759529e-01 | 0.170 |
| R-HSA-5617833 | Cilium Assembly | 6.764338e-01 | 0.170 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.793587e-01 | 0.168 |
| R-HSA-391251 | Protein folding | 6.793587e-01 | 0.168 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.829258e-01 | 0.166 |
| R-HSA-195721 | Signaling by WNT | 6.883421e-01 | 0.162 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 6.899419e-01 | 0.161 |
| R-HSA-597592 | Post-translational protein modification | 6.942793e-01 | 0.158 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.968037e-01 | 0.157 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.968037e-01 | 0.157 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.968037e-01 | 0.157 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.001778e-01 | 0.155 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.035145e-01 | 0.153 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.068143e-01 | 0.151 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.081473e-01 | 0.150 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.081473e-01 | 0.150 |
| R-HSA-70171 | Glycolysis | 7.100775e-01 | 0.149 |
| R-HSA-5357801 | Programmed Cell Death | 7.150891e-01 | 0.146 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.164961e-01 | 0.145 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.227733e-01 | 0.141 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.280750e-01 | 0.138 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.289123e-01 | 0.137 |
| R-HSA-69239 | Synthesis of DNA | 7.349161e-01 | 0.134 |
| R-HSA-8957322 | Metabolism of steroids | 7.380801e-01 | 0.132 |
| R-HSA-8953854 | Metabolism of RNA | 7.400152e-01 | 0.131 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.407877e-01 | 0.130 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.436748e-01 | 0.129 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.493534e-01 | 0.125 |
| R-HSA-8951664 | Neddylation | 7.498170e-01 | 0.125 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.549069e-01 | 0.122 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.576375e-01 | 0.121 |
| R-HSA-162906 | HIV Infection | 7.618767e-01 | 0.118 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.630085e-01 | 0.117 |
| R-HSA-70326 | Glucose metabolism | 7.682610e-01 | 0.114 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.682610e-01 | 0.114 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.708438e-01 | 0.113 |
| R-HSA-6798695 | Neutrophil degranulation | 7.805293e-01 | 0.108 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.833342e-01 | 0.106 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.833342e-01 | 0.106 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.857498e-01 | 0.105 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.857498e-01 | 0.105 |
| R-HSA-194138 | Signaling by VEGF | 7.905010e-01 | 0.102 |
| R-HSA-69481 | G2/M Checkpoints | 7.951474e-01 | 0.100 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.974320e-01 | 0.098 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.019255e-01 | 0.096 |
| R-HSA-9909396 | Circadian clock | 8.084806e-01 | 0.092 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.189297e-01 | 0.087 |
| R-HSA-163685 | Integration of energy metabolism | 8.189297e-01 | 0.087 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.189297e-01 | 0.087 |
| R-HSA-416476 | G alpha (q) signalling events | 8.256655e-01 | 0.083 |
| R-HSA-1632852 | Macroautophagy | 8.288118e-01 | 0.082 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.363298e-01 | 0.078 |
| R-HSA-166520 | Signaling by NTRKs | 8.435194e-01 | 0.074 |
| R-HSA-69306 | DNA Replication | 8.520662e-01 | 0.070 |
| R-HSA-9609507 | Protein localization | 8.520662e-01 | 0.070 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.537190e-01 | 0.069 |
| R-HSA-1989781 | PPARA activates gene expression | 8.553535e-01 | 0.068 |
| R-HSA-9612973 | Autophagy | 8.569698e-01 | 0.067 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.585681e-01 | 0.066 |
| R-HSA-9610379 | HCMV Late Events | 8.585681e-01 | 0.066 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.648943e-01 | 0.063 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.736062e-01 | 0.059 |
| R-HSA-5619102 | SLC transporter disorders | 8.736062e-01 | 0.059 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.805178e-01 | 0.055 |
| R-HSA-9824446 | Viral Infection Pathways | 8.974548e-01 | 0.047 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.077722e-01 | 0.042 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.118153e-01 | 0.040 |
| R-HSA-72172 | mRNA Splicing | 9.185244e-01 | 0.037 |
| R-HSA-6805567 | Keratinization | 9.203408e-01 | 0.036 |
| R-HSA-72312 | rRNA processing | 9.405944e-01 | 0.027 |
| R-HSA-8939211 | ESR-mediated signaling | 9.438562e-01 | 0.025 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.438562e-01 | 0.025 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.479272e-01 | 0.023 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.498550e-01 | 0.022 |
| R-HSA-8978868 | Fatty acid metabolism | 9.526011e-01 | 0.021 |
| R-HSA-422475 | Axon guidance | 9.526061e-01 | 0.021 |
| R-HSA-1266738 | Developmental Biology | 9.597726e-01 | 0.018 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.630536e-01 | 0.016 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.646898e-01 | 0.016 |
| R-HSA-9675108 | Nervous system development | 9.653886e-01 | 0.015 |
| R-HSA-168249 | Innate Immune System | 9.683071e-01 | 0.014 |
| R-HSA-556833 | Metabolism of lipids | 9.760102e-01 | 0.011 |
| R-HSA-449147 | Signaling by Interleukins | 9.761718e-01 | 0.010 |
| R-HSA-1474244 | Extracellular matrix organization | 9.806458e-01 | 0.008 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.865510e-01 | 0.006 |
| R-HSA-1643685 | Disease | 9.891635e-01 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 9.895865e-01 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.902254e-01 | 0.004 |
| R-HSA-5663205 | Infectious disease | 9.937290e-01 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.953504e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.978699e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.757 | 0.303 | 2 | 0.902 |
GRK1 |
0.757 | 0.272 | -2 | 0.615 |
COT |
0.754 | 0.100 | 2 | 0.677 |
CLK3 |
0.753 | 0.164 | 1 | 0.776 |
KIS |
0.750 | 0.152 | 1 | 0.632 |
PIM3 |
0.748 | 0.123 | -3 | 0.840 |
NDR2 |
0.746 | 0.148 | -3 | 0.841 |
IKKB |
0.745 | 0.034 | -2 | 0.418 |
PRKD1 |
0.743 | 0.136 | -3 | 0.813 |
MOS |
0.742 | 0.142 | 1 | 0.783 |
SRPK1 |
0.741 | 0.094 | -3 | 0.764 |
SKMLCK |
0.740 | 0.105 | -2 | 0.407 |
PRPK |
0.739 | 0.041 | -1 | 0.274 |
RSK2 |
0.739 | 0.094 | -3 | 0.791 |
HIPK4 |
0.738 | 0.082 | 1 | 0.763 |
IKKA |
0.737 | 0.077 | -2 | 0.425 |
PIM1 |
0.737 | 0.102 | -3 | 0.813 |
CDC7 |
0.737 | -0.001 | 1 | 0.743 |
PRKD2 |
0.737 | 0.054 | -3 | 0.797 |
P90RSK |
0.735 | 0.105 | -3 | 0.784 |
MARK4 |
0.735 | 0.057 | 4 | 0.859 |
ATR |
0.734 | 0.067 | 1 | 0.802 |
AURC |
0.734 | 0.005 | -2 | 0.274 |
TBK1 |
0.734 | 0.032 | 1 | 0.702 |
DSTYK |
0.733 | 0.004 | 2 | 0.709 |
ERK5 |
0.733 | 0.025 | 1 | 0.765 |
TGFBR2 |
0.733 | 0.003 | -2 | 0.431 |
NUAK2 |
0.733 | 0.047 | -3 | 0.860 |
NDR1 |
0.732 | 0.039 | -3 | 0.845 |
CAMK1B |
0.732 | 0.008 | -3 | 0.865 |
PDHK4 |
0.731 | -0.027 | 1 | 0.795 |
CHAK2 |
0.731 | -0.012 | -1 | 0.255 |
RAF1 |
0.731 | -0.035 | 1 | 0.786 |
TSSK1 |
0.731 | 0.090 | -3 | 0.875 |
LATS1 |
0.731 | 0.239 | -3 | 0.841 |
IKKE |
0.731 | 0.014 | 1 | 0.701 |
LATS2 |
0.731 | 0.091 | -5 | 0.713 |
NLK |
0.730 | -0.003 | 1 | 0.765 |
CAMK2D |
0.730 | 0.081 | -3 | 0.837 |
CDKL1 |
0.730 | 0.016 | -3 | 0.801 |
GRK5 |
0.730 | 0.009 | -3 | 0.833 |
CDKL5 |
0.729 | 0.019 | -3 | 0.794 |
CAMK2G |
0.729 | -0.002 | 2 | 0.672 |
AMPKA1 |
0.729 | 0.037 | -3 | 0.865 |
PKACG |
0.728 | 0.005 | -2 | 0.332 |
TSSK2 |
0.728 | 0.066 | -5 | 0.858 |
PRKX |
0.727 | 0.054 | -3 | 0.738 |
WNK1 |
0.727 | -0.030 | -2 | 0.407 |
CAMK2B |
0.727 | 0.105 | 2 | 0.711 |
MTOR |
0.727 | -0.066 | 1 | 0.726 |
RSK4 |
0.727 | 0.106 | -3 | 0.763 |
PKN3 |
0.727 | 0.038 | -3 | 0.826 |
GRK4 |
0.727 | 0.066 | -2 | 0.546 |
RIPK3 |
0.727 | -0.012 | 3 | 0.774 |
BMPR2 |
0.727 | -0.096 | -2 | 0.441 |
GRK7 |
0.726 | 0.137 | 1 | 0.689 |
QSK |
0.725 | 0.049 | 4 | 0.846 |
PKCD |
0.725 | 0.015 | 2 | 0.584 |
AMPKA2 |
0.725 | 0.044 | -3 | 0.842 |
MAPKAPK2 |
0.725 | 0.056 | -3 | 0.760 |
MST4 |
0.725 | -0.026 | 2 | 0.626 |
MLK1 |
0.725 | -0.041 | 2 | 0.602 |
NIK |
0.725 | -0.015 | -3 | 0.873 |
RSK3 |
0.725 | 0.021 | -3 | 0.774 |
PKACB |
0.725 | 0.029 | -2 | 0.274 |
SRPK2 |
0.724 | 0.048 | -3 | 0.696 |
GCN2 |
0.724 | -0.130 | 2 | 0.597 |
MASTL |
0.724 | 0.021 | -2 | 0.421 |
SRPK3 |
0.724 | 0.060 | -3 | 0.731 |
MAPKAPK3 |
0.724 | 0.007 | -3 | 0.795 |
CAMLCK |
0.723 | -0.017 | -2 | 0.384 |
ICK |
0.723 | 0.022 | -3 | 0.832 |
PKN2 |
0.723 | -0.004 | -3 | 0.853 |
HUNK |
0.722 | 0.001 | 2 | 0.596 |
CAMK2A |
0.722 | 0.085 | 2 | 0.662 |
ULK2 |
0.722 | -0.163 | 2 | 0.597 |
ATM |
0.722 | 0.027 | 1 | 0.750 |
MNK1 |
0.722 | 0.051 | -2 | 0.329 |
TTBK2 |
0.722 | 0.015 | 2 | 0.528 |
BMPR1B |
0.722 | 0.059 | 1 | 0.686 |
PDHK1 |
0.722 | -0.123 | 1 | 0.794 |
DYRK2 |
0.721 | 0.039 | 1 | 0.673 |
BCKDK |
0.721 | -0.084 | -1 | 0.198 |
NUAK1 |
0.720 | 0.022 | -3 | 0.817 |
AURB |
0.720 | -0.019 | -2 | 0.273 |
PKG2 |
0.720 | 0.001 | -2 | 0.274 |
DAPK2 |
0.719 | -0.016 | -3 | 0.859 |
NIM1 |
0.719 | -0.063 | 3 | 0.810 |
SIK |
0.718 | 0.014 | -3 | 0.787 |
HIPK1 |
0.718 | 0.069 | 1 | 0.684 |
QIK |
0.718 | -0.028 | -3 | 0.838 |
CLK2 |
0.718 | 0.078 | -3 | 0.784 |
MLK2 |
0.718 | -0.059 | 2 | 0.616 |
GRK6 |
0.718 | -0.021 | 1 | 0.752 |
NEK6 |
0.718 | -0.134 | -2 | 0.420 |
IRE1 |
0.718 | -0.042 | 1 | 0.782 |
MARK3 |
0.718 | 0.034 | 4 | 0.805 |
HIPK2 |
0.717 | 0.060 | 1 | 0.582 |
MLK3 |
0.717 | -0.022 | 2 | 0.544 |
CK1E |
0.717 | 0.121 | -3 | 0.584 |
PKCB |
0.717 | 0.001 | 2 | 0.536 |
P70S6KB |
0.717 | -0.028 | -3 | 0.817 |
PRKD3 |
0.717 | 0.010 | -3 | 0.767 |
PIM2 |
0.717 | 0.058 | -3 | 0.776 |
MSK2 |
0.716 | 0.002 | -3 | 0.750 |
DNAPK |
0.716 | 0.062 | 1 | 0.727 |
PKCG |
0.716 | -0.007 | 2 | 0.528 |
PAK1 |
0.716 | -0.047 | -2 | 0.336 |
CDK8 |
0.716 | -0.005 | 1 | 0.598 |
GRK2 |
0.716 | 0.048 | -2 | 0.475 |
MELK |
0.715 | -0.023 | -3 | 0.828 |
MSK1 |
0.715 | 0.032 | -3 | 0.760 |
WNK3 |
0.715 | -0.151 | 1 | 0.775 |
CK1D |
0.714 | 0.138 | -3 | 0.542 |
NEK7 |
0.714 | -0.175 | -3 | 0.793 |
CDK1 |
0.714 | 0.044 | 1 | 0.573 |
MARK2 |
0.714 | 0.026 | 4 | 0.774 |
RIPK1 |
0.714 | -0.070 | 1 | 0.773 |
PKCZ |
0.714 | -0.026 | 2 | 0.577 |
MPSK1 |
0.714 | 0.143 | 1 | 0.750 |
PKCA |
0.714 | -0.004 | 2 | 0.532 |
IRE2 |
0.714 | -0.004 | 2 | 0.551 |
CDK19 |
0.714 | 0.006 | 1 | 0.567 |
PAK6 |
0.714 | -0.050 | -2 | 0.288 |
CHK1 |
0.714 | 0.060 | -3 | 0.825 |
SSTK |
0.714 | 0.063 | 4 | 0.829 |
CLK4 |
0.713 | 0.008 | -3 | 0.800 |
MYLK4 |
0.713 | -0.012 | -2 | 0.351 |
CAMK4 |
0.713 | -0.037 | -3 | 0.843 |
BRSK2 |
0.713 | 0.011 | -3 | 0.835 |
BRSK1 |
0.713 | 0.016 | -3 | 0.809 |
TGFBR1 |
0.712 | 0.001 | -2 | 0.445 |
PAK3 |
0.712 | -0.076 | -2 | 0.328 |
CDK18 |
0.712 | 0.025 | 1 | 0.554 |
ALK4 |
0.712 | -0.019 | -2 | 0.447 |
PKACA |
0.712 | 0.011 | -2 | 0.241 |
MNK2 |
0.712 | -0.075 | -2 | 0.315 |
CDK7 |
0.711 | -0.019 | 1 | 0.609 |
SMG1 |
0.711 | -0.034 | 1 | 0.777 |
PKR |
0.711 | -0.045 | 1 | 0.820 |
ALK2 |
0.711 | 0.035 | -2 | 0.476 |
GRK3 |
0.711 | 0.068 | -2 | 0.496 |
MARK1 |
0.711 | 0.010 | 4 | 0.823 |
AKT2 |
0.710 | 0.014 | -3 | 0.728 |
DLK |
0.710 | -0.094 | 1 | 0.744 |
AURA |
0.710 | -0.029 | -2 | 0.273 |
PASK |
0.710 | 0.191 | -3 | 0.841 |
CLK1 |
0.710 | 0.006 | -3 | 0.784 |
PKCH |
0.710 | -0.021 | 2 | 0.524 |
ANKRD3 |
0.709 | -0.134 | 1 | 0.794 |
CDK5 |
0.709 | 0.020 | 1 | 0.633 |
YSK4 |
0.709 | -0.034 | 1 | 0.711 |
NEK9 |
0.709 | -0.188 | 2 | 0.623 |
CHAK1 |
0.708 | -0.077 | 2 | 0.572 |
PHKG1 |
0.708 | -0.046 | -3 | 0.842 |
MLK4 |
0.708 | -0.060 | 2 | 0.539 |
ACVR2A |
0.708 | -0.040 | -2 | 0.416 |
SGK3 |
0.707 | -0.012 | -3 | 0.790 |
PAK2 |
0.707 | -0.068 | -2 | 0.337 |
ULK1 |
0.707 | -0.182 | -3 | 0.769 |
P38B |
0.707 | 0.017 | 1 | 0.591 |
CK1G1 |
0.706 | 0.082 | -3 | 0.577 |
CAMK1G |
0.706 | -0.002 | -3 | 0.785 |
JNK3 |
0.705 | 0.025 | 1 | 0.592 |
ACVR2B |
0.705 | -0.041 | -2 | 0.433 |
JNK2 |
0.705 | 0.018 | 1 | 0.558 |
PERK |
0.705 | -0.068 | -2 | 0.467 |
DYRK1A |
0.705 | 0.028 | 1 | 0.678 |
HIPK3 |
0.705 | 0.021 | 1 | 0.675 |
TLK2 |
0.704 | -0.072 | 1 | 0.773 |
CDK17 |
0.704 | 0.018 | 1 | 0.500 |
P38A |
0.704 | -0.009 | 1 | 0.654 |
ERK1 |
0.703 | -0.001 | 1 | 0.578 |
VRK2 |
0.703 | -0.100 | 1 | 0.815 |
MEK1 |
0.703 | -0.113 | 2 | 0.637 |
PLK1 |
0.703 | -0.128 | -2 | 0.391 |
PLK3 |
0.702 | -0.047 | 2 | 0.621 |
DCAMKL1 |
0.702 | -0.000 | -3 | 0.817 |
DYRK4 |
0.702 | 0.031 | 1 | 0.583 |
AKT1 |
0.702 | -0.000 | -3 | 0.749 |
CDK14 |
0.702 | 0.025 | 1 | 0.599 |
CDK3 |
0.702 | 0.046 | 1 | 0.518 |
DYRK1B |
0.701 | 0.022 | 1 | 0.617 |
CK1A2 |
0.701 | 0.078 | -3 | 0.544 |
P38D |
0.701 | 0.039 | 1 | 0.524 |
CAMK1D |
0.701 | 0.032 | -3 | 0.734 |
CDK13 |
0.701 | -0.035 | 1 | 0.589 |
BMPR1A |
0.701 | 0.003 | 1 | 0.658 |
MEKK3 |
0.700 | -0.024 | 1 | 0.735 |
IRAK4 |
0.700 | -0.080 | 1 | 0.788 |
CDK2 |
0.700 | -0.018 | 1 | 0.651 |
MST3 |
0.699 | -0.007 | 2 | 0.595 |
PKCT |
0.699 | -0.042 | 2 | 0.534 |
SNRK |
0.699 | -0.104 | 2 | 0.487 |
DYRK3 |
0.698 | 0.003 | 1 | 0.695 |
TLK1 |
0.698 | -0.055 | -2 | 0.465 |
MAPKAPK5 |
0.698 | -0.070 | -3 | 0.722 |
MEKK2 |
0.698 | -0.058 | 2 | 0.604 |
PKCE |
0.697 | 0.004 | 2 | 0.517 |
CDK16 |
0.697 | 0.021 | 1 | 0.521 |
MAK |
0.697 | 0.039 | -2 | 0.314 |
TTBK1 |
0.697 | -0.049 | 2 | 0.463 |
ERK2 |
0.697 | -0.026 | 1 | 0.625 |
P38G |
0.697 | 0.000 | 1 | 0.491 |
GAK |
0.696 | 0.091 | 1 | 0.790 |
WNK4 |
0.696 | -0.106 | -2 | 0.400 |
PRP4 |
0.696 | -0.021 | -3 | 0.733 |
CDK10 |
0.696 | 0.017 | 1 | 0.585 |
NEK2 |
0.696 | -0.177 | 2 | 0.597 |
MEK5 |
0.696 | -0.109 | 2 | 0.618 |
TAO3 |
0.696 | -0.031 | 1 | 0.728 |
CDK9 |
0.695 | -0.034 | 1 | 0.599 |
IRAK1 |
0.695 | -0.107 | -1 | 0.171 |
PKCI |
0.695 | -0.057 | 2 | 0.544 |
HRI |
0.695 | -0.155 | -2 | 0.418 |
CDK12 |
0.695 | -0.032 | 1 | 0.564 |
SMMLCK |
0.695 | -0.035 | -3 | 0.825 |
PAK5 |
0.695 | -0.076 | -2 | 0.269 |
BRAF |
0.694 | -0.101 | -4 | 0.872 |
MEKK1 |
0.694 | -0.090 | 1 | 0.751 |
AKT3 |
0.694 | 0.008 | -3 | 0.668 |
ZAK |
0.694 | -0.096 | 1 | 0.696 |
PLK4 |
0.693 | -0.126 | 2 | 0.445 |
PAK4 |
0.693 | -0.068 | -2 | 0.270 |
P70S6K |
0.693 | -0.032 | -3 | 0.731 |
DAPK3 |
0.692 | 0.003 | -3 | 0.825 |
PHKG2 |
0.692 | -0.052 | -3 | 0.832 |
MOK |
0.692 | 0.032 | 1 | 0.729 |
ROCK2 |
0.691 | 0.028 | -3 | 0.818 |
DCAMKL2 |
0.691 | -0.045 | -3 | 0.839 |
NEK5 |
0.690 | -0.140 | 1 | 0.797 |
GCK |
0.690 | 0.044 | 1 | 0.760 |
PINK1 |
0.689 | -0.159 | 1 | 0.782 |
ERK7 |
0.688 | -0.021 | 2 | 0.408 |
BUB1 |
0.688 | 0.020 | -5 | 0.802 |
SGK1 |
0.687 | 0.011 | -3 | 0.653 |
DRAK1 |
0.687 | -0.114 | 1 | 0.654 |
GSK3A |
0.687 | 0.021 | 4 | 0.409 |
GSK3B |
0.687 | -0.000 | 4 | 0.400 |
SBK |
0.687 | 0.047 | -3 | 0.624 |
MINK |
0.686 | -0.006 | 1 | 0.764 |
DMPK1 |
0.686 | 0.057 | -3 | 0.807 |
TNIK |
0.686 | -0.015 | 3 | 0.867 |
CAMK1A |
0.686 | 0.008 | -3 | 0.701 |
MRCKA |
0.686 | 0.003 | -3 | 0.792 |
PLK2 |
0.686 | 0.007 | -3 | 0.716 |
CK2A2 |
0.686 | 0.009 | 1 | 0.598 |
KHS1 |
0.686 | 0.052 | 1 | 0.769 |
SLK |
0.686 | -0.043 | -2 | 0.367 |
PDK1 |
0.686 | -0.045 | 1 | 0.731 |
TAO2 |
0.685 | -0.084 | 2 | 0.635 |
HGK |
0.685 | -0.039 | 3 | 0.866 |
CAMKK1 |
0.685 | -0.172 | -2 | 0.404 |
MRCKB |
0.685 | -0.019 | -3 | 0.776 |
HPK1 |
0.685 | -0.001 | 1 | 0.756 |
PKN1 |
0.685 | -0.023 | -3 | 0.756 |
LRRK2 |
0.685 | -0.060 | 2 | 0.628 |
JNK1 |
0.684 | 0.013 | 1 | 0.547 |
DAPK1 |
0.684 | -0.011 | -3 | 0.806 |
NEK8 |
0.683 | -0.143 | 2 | 0.596 |
MST2 |
0.683 | -0.055 | 1 | 0.762 |
KHS2 |
0.682 | 0.028 | 1 | 0.777 |
CHK2 |
0.682 | -0.002 | -3 | 0.687 |
PKG1 |
0.682 | -0.045 | -2 | 0.212 |
HASPIN |
0.682 | -0.014 | -1 | 0.193 |
NEK11 |
0.682 | -0.095 | 1 | 0.722 |
LOK |
0.682 | -0.084 | -2 | 0.355 |
LKB1 |
0.682 | -0.104 | -3 | 0.798 |
CAMKK2 |
0.681 | -0.168 | -2 | 0.388 |
EEF2K |
0.681 | -0.043 | 3 | 0.834 |
CDK6 |
0.680 | -0.014 | 1 | 0.576 |
TAK1 |
0.680 | -0.067 | 1 | 0.757 |
PBK |
0.679 | -0.000 | 1 | 0.734 |
NEK4 |
0.679 | -0.143 | 1 | 0.778 |
MAP3K15 |
0.678 | -0.040 | 1 | 0.685 |
PDHK3_TYR |
0.678 | 0.115 | 4 | 0.874 |
MST1 |
0.677 | -0.038 | 1 | 0.758 |
CK2A1 |
0.677 | 0.006 | 1 | 0.575 |
MEKK6 |
0.677 | -0.083 | 1 | 0.737 |
STK33 |
0.676 | -0.110 | 2 | 0.454 |
CK1A |
0.675 | 0.086 | -3 | 0.458 |
CDK4 |
0.675 | -0.034 | 1 | 0.559 |
ROCK1 |
0.674 | -0.015 | -3 | 0.791 |
TTK |
0.674 | -0.010 | -2 | 0.430 |
YANK3 |
0.673 | 0.007 | 2 | 0.308 |
VRK1 |
0.673 | -0.126 | 2 | 0.615 |
NEK1 |
0.673 | -0.148 | 1 | 0.772 |
PDHK4_TYR |
0.671 | 0.090 | 2 | 0.676 |
TESK1_TYR |
0.669 | 0.039 | 3 | 0.896 |
YSK1 |
0.669 | -0.107 | 2 | 0.593 |
PKMYT1_TYR |
0.669 | 0.047 | 3 | 0.865 |
CRIK |
0.669 | 0.009 | -3 | 0.741 |
MAP2K4_TYR |
0.669 | -0.017 | -1 | 0.264 |
MAP2K6_TYR |
0.669 | 0.029 | -1 | 0.260 |
FGR |
0.667 | 0.162 | 1 | 0.793 |
ALPHAK3 |
0.667 | 0.028 | -1 | 0.218 |
BMPR2_TYR |
0.667 | -0.016 | -1 | 0.226 |
LIMK2_TYR |
0.665 | -0.003 | -3 | 0.870 |
RIPK2 |
0.665 | -0.166 | 1 | 0.653 |
MYO3B |
0.664 | -0.075 | 2 | 0.602 |
MAP2K7_TYR |
0.663 | -0.090 | 2 | 0.656 |
PDHK1_TYR |
0.663 | -0.002 | -1 | 0.257 |
BIKE |
0.663 | -0.004 | 1 | 0.694 |
OSR1 |
0.662 | -0.089 | 2 | 0.594 |
MYO3A |
0.661 | -0.069 | 1 | 0.778 |
MEK2 |
0.661 | -0.216 | 2 | 0.607 |
ABL2 |
0.658 | -0.032 | -1 | 0.211 |
PINK1_TYR |
0.658 | -0.139 | 1 | 0.761 |
EPHA6 |
0.657 | -0.060 | -1 | 0.210 |
YES1 |
0.657 | 0.031 | -1 | 0.291 |
ROS1 |
0.657 | 0.002 | 3 | 0.791 |
FER |
0.657 | -0.009 | 1 | 0.793 |
LIMK1_TYR |
0.657 | -0.092 | 2 | 0.654 |
TYK2 |
0.657 | -0.060 | 1 | 0.753 |
NEK3 |
0.656 | -0.204 | 1 | 0.708 |
AAK1 |
0.656 | 0.056 | 1 | 0.606 |
RET |
0.655 | -0.085 | 1 | 0.751 |
LCK |
0.655 | 0.005 | -1 | 0.231 |
TAO1 |
0.654 | -0.112 | 1 | 0.669 |
ASK1 |
0.654 | -0.080 | 1 | 0.665 |
ABL1 |
0.654 | -0.054 | -1 | 0.210 |
EPHB4 |
0.653 | -0.095 | -1 | 0.214 |
TXK |
0.653 | -0.027 | 1 | 0.727 |
INSRR |
0.653 | 0.011 | 3 | 0.772 |
JAK2 |
0.652 | -0.062 | 1 | 0.738 |
TNK2 |
0.652 | -0.030 | 3 | 0.778 |
HCK |
0.652 | -0.036 | -1 | 0.229 |
BLK |
0.652 | 0.010 | -1 | 0.224 |
TYRO3 |
0.652 | -0.101 | 3 | 0.817 |
FYN |
0.652 | 0.052 | -1 | 0.254 |
MST1R |
0.652 | -0.100 | 3 | 0.821 |
CSF1R |
0.650 | -0.044 | 3 | 0.795 |
WEE1_TYR |
0.649 | -0.051 | -1 | 0.212 |
TNNI3K_TYR |
0.649 | -0.040 | 1 | 0.775 |
SRMS |
0.649 | -0.048 | 1 | 0.762 |
DDR1 |
0.648 | -0.077 | 4 | 0.787 |
CK1G3 |
0.648 | 0.057 | -3 | 0.415 |
YANK2 |
0.648 | -0.001 | 2 | 0.340 |
TNK1 |
0.648 | -0.052 | 3 | 0.797 |
JAK1 |
0.647 | -0.009 | 1 | 0.687 |
CK1G2 |
0.646 | 0.088 | -3 | 0.501 |
EPHA4 |
0.646 | -0.046 | 2 | 0.620 |
JAK3 |
0.645 | -0.106 | 1 | 0.700 |
BMX |
0.645 | -0.064 | -1 | 0.186 |
ITK |
0.645 | -0.096 | -1 | 0.199 |
KIT |
0.644 | -0.056 | 3 | 0.797 |
MET |
0.644 | -0.029 | 3 | 0.800 |
SYK |
0.644 | 0.065 | -1 | 0.202 |
FGFR2 |
0.644 | -0.065 | 3 | 0.810 |
TEC |
0.643 | -0.082 | -1 | 0.187 |
BTK |
0.643 | -0.108 | -1 | 0.201 |
PDGFRB |
0.642 | -0.115 | 3 | 0.816 |
KDR |
0.642 | -0.075 | 3 | 0.762 |
STLK3 |
0.642 | -0.147 | 1 | 0.677 |
FLT3 |
0.642 | -0.089 | 3 | 0.800 |
SRC |
0.642 | 0.021 | -1 | 0.262 |
EPHB2 |
0.642 | -0.094 | -1 | 0.192 |
PTK6 |
0.642 | -0.131 | -1 | 0.224 |
EPHB3 |
0.642 | -0.115 | -1 | 0.202 |
LYN |
0.641 | -0.021 | 3 | 0.727 |
ALK |
0.641 | -0.068 | 3 | 0.741 |
LTK |
0.640 | -0.083 | 3 | 0.752 |
EPHB1 |
0.640 | -0.132 | 1 | 0.753 |
AXL |
0.639 | -0.121 | 3 | 0.789 |
NEK10_TYR |
0.639 | -0.115 | 1 | 0.615 |
MERTK |
0.639 | -0.107 | 3 | 0.778 |
FGFR1 |
0.639 | -0.084 | 3 | 0.780 |
TEK |
0.638 | -0.094 | 3 | 0.758 |
INSR |
0.638 | -0.045 | 3 | 0.756 |
PTK2 |
0.638 | -0.006 | -1 | 0.192 |
DDR2 |
0.638 | 0.025 | 3 | 0.763 |
ERBB2 |
0.637 | -0.054 | 1 | 0.694 |
MATK |
0.636 | -0.068 | -1 | 0.196 |
FLT1 |
0.636 | -0.090 | -1 | 0.211 |
PDGFRA |
0.635 | -0.133 | 3 | 0.812 |
FGFR3 |
0.635 | -0.059 | 3 | 0.785 |
NTRK1 |
0.635 | -0.095 | -1 | 0.247 |
EPHA3 |
0.635 | -0.094 | 2 | 0.590 |
NTRK3 |
0.635 | -0.062 | -1 | 0.250 |
EGFR |
0.634 | -0.021 | 1 | 0.593 |
EPHA7 |
0.632 | -0.099 | 2 | 0.619 |
PTK2B |
0.632 | -0.075 | -1 | 0.204 |
EPHA5 |
0.631 | -0.065 | 2 | 0.621 |
FGFR4 |
0.630 | -0.043 | -1 | 0.213 |
FRK |
0.630 | -0.103 | -1 | 0.201 |
ZAP70 |
0.630 | 0.037 | -1 | 0.176 |
EPHA1 |
0.630 | -0.129 | 3 | 0.768 |
NTRK2 |
0.629 | -0.137 | 3 | 0.762 |
EPHA8 |
0.628 | -0.077 | -1 | 0.196 |
FLT4 |
0.626 | -0.140 | 3 | 0.752 |
ERBB4 |
0.624 | -0.002 | 1 | 0.623 |
IGF1R |
0.624 | -0.049 | 3 | 0.700 |
CSK |
0.623 | -0.118 | 2 | 0.609 |
EPHA2 |
0.617 | -0.099 | -1 | 0.175 |
MUSK |
0.615 | -0.134 | 1 | 0.596 |
FES |
0.613 | -0.090 | -1 | 0.195 |