Motif 395 (n=85)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B9A064 | IGLL5 | S194 | ochoa | Immunoglobulin lambda-like polypeptide 5 (G lambda-1) (Germline immunoglobulin lambda 1) | None |
| H0YIS7 | RNASEK-C17orf49 | S162 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| M0R1B8 | None | S54 | ochoa | Uncharacterized protein | None |
| O00186 | STXBP3 | S512 | ochoa | Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) | Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}. |
| O14545 | TRAFD1 | S280 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14828 | SCAMP3 | S87 | ochoa | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15417 | TNRC18 | S1138 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43815 | STRN | S378 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O75143 | ATG13 | S480 | ochoa | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O75179 | ANKRD17 | S209 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75955 | FLOT1 | S385 | ochoa | Flotillin-1 | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| O94915 | FRYL | S1484 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94986 | CEP152 | S1247 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| P05549 | TFAP2A | S225 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P0CF74 | IGLC6 | S86 | ochoa | Immunoglobulin lambda constant 6 (Ig lambda-6 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0CG04 | IGLC1 | S86 | ochoa | Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0DOY2 | IGLC2 | S86 | ochoa | Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0DOY3 | IGLC3 | S86 | ochoa | Immunoglobulin lambda constant 3 (Ig lambda chain C region DOT) (Ig lambda chain C region NEWM) (Ig lambda-3 chain C regions) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P14859 | POU2F1 | S269 | ochoa | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P21980 | TGM2 | S385 | ochoa | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P29536 | LMOD1 | S135 | ochoa | Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) | Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}. |
| P46108 | CRK | S121 | ochoa | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| P46937 | YAP1 | S105 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P46937 | YAP1 | S149 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P49247 | RPIA | S106 | ochoa | Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase) | Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate and participates in the first step of the non-oxidative branch of the pentose phosphate pathway. {ECO:0000269|PubMed:14988808}. |
| P51531 | SMARCA2 | S700 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P52739 | ZNF131 | S579 | ochoa | Zinc finger protein 131 | Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269|PubMed:18847501, ECO:0000269|PubMed:22467880}. |
| P54198 | HIRA | S614 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| Q08AD1 | CAMSAP2 | S879 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q13554 | CAMK2B | S397 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13761 | RUNX3 | S220 | ochoa | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q14432 | PDE3A | S492 | ochoa|psp | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14739 | LBR | S101 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q14847 | LASP1 | S61 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q4G0F5 | VPS26B | S304 | ochoa | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). {ECO:0000250|UniProtKB:O75436, ECO:0000250|UniProtKB:Q8C0E2}. |
| Q5JSH3 | WDR44 | S199 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5SRE5 | NUP188 | S1532 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q68CZ2 | TNS3 | S390 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68CZ2 | TNS3 | S1201 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6N022 | TENM4 | S221 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
| Q6T4R5 | NHS | S1327 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6UUV9 | CRTC1 | S172 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6VUC0 | TFAP2E | S232 | ochoa | Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
| Q6WKZ4 | RAB11FIP1 | S1216 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZVL6 | KIAA1549L | S1683 | ochoa | UPF0606 protein KIAA1549L | None |
| Q7L9B9 | EEPD1 | S21 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z2W4 | ZC3HAV1 | S494 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z418 | KCNK18 | S264 | psp | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) | K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors (PubMed:12754259, PubMed:15562060, PubMed:20871611, PubMed:22355750, PubMed:26919430, PubMed:30573346). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets (PubMed:34702947). Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (By similarity). {ECO:0000250|UniProtKB:Q6VV64, ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611, ECO:0000269|PubMed:22355750, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:30573346, ECO:0000269|PubMed:34702947}. |
| Q7Z6I6 | ARHGAP30 | S632 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6R9 | TFAP2D | S225 | ochoa | Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}. |
| Q8IUD2 | ERC1 | S997 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IVT2 | MISP | S451 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWZ3 | ANKHD1 | S180 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IXM2 | BACC1 | S121 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8WWI1 | LMO7 | S971 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWI1 | LMO7 | S997 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXI9 | GATAD2B | S497 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q92481 | TFAP2B | S244 | ochoa | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
| Q92625 | ANKS1A | S887 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92754 | TFAP2C | S238 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
| Q96FF9 | CDCA5 | S158 | ochoa | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96GZ6 | SLC41A3 | S27 | ochoa | Solute carrier family 41 member 3 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane. {ECO:0000269|PubMed:27302215}. |
| Q96PE2 | ARHGEF17 | S463 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q9BXF6 | RAB11FIP5 | S566 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXI6 | TBC1D10A | S20 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
| Q9BYW2 | SETD2 | S1236 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H4A3 | WNK1 | S185 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H792 | PEAK1 | S1005 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H813 | PACC1 | S50 | ochoa | Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) | Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332). {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}. |
| Q9NQX7 | ITM2C | S24 | ochoa | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}. |
| Q9NSC5 | HOMER3 | S159 | ochoa | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
| Q9UER7 | DAXX | S178 | ochoa|psp | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UJF2 | RASAL2 | S899 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9ULT0 | TTC7A | S674 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9UNK9 | ANGEL1 | S38 | ochoa | Protein angel homolog 1 | None |
| Q9UPN4 | CEP131 | S116 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y250 | LZTS1 | S174 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y2I7 | PIKFYVE | S329 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| P41091 | EIF2S3 | S412 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| Q2VIR3 | EIF2S3B | S412 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}. |
| Q5T1R4 | HIVEP3 | S1680 | Sugiyama | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| P20042 | EIF2S2 | S160 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| Q8N5S9 | CAMKK1 | S111 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| P42566 | EPS15 | S748 | Sugiyama | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| Q9H093 | NUAK2 | S327 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 6.443879e-11 | 10.191 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.013172e-08 | 7.994 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.975233e-07 | 6.224 |
| R-HSA-9834899 | Specification of the neural plate border | 1.189003e-05 | 4.925 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.165147e-05 | 4.665 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.472684e-04 | 3.607 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 3.876034e-04 | 3.412 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 5.561008e-04 | 3.255 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.281127e-04 | 3.202 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 7.836938e-04 | 3.106 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.154291e-03 | 2.938 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.237515e-03 | 2.907 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.522199e-03 | 2.818 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 2.320176e-03 | 2.634 |
| R-HSA-2029481 | FCGR activation | 2.875260e-03 | 2.541 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.544372e-03 | 2.594 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.046211e-03 | 2.689 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.046211e-03 | 2.689 |
| R-HSA-9664407 | Parasite infection | 2.046211e-03 | 2.689 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.875260e-03 | 2.541 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.835117e-03 | 2.736 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.102960e-03 | 2.677 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 2.175947e-03 | 2.662 |
| R-HSA-9758941 | Gastrulation | 2.666711e-03 | 2.574 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.735491e-03 | 2.563 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.292039e-03 | 2.483 |
| R-HSA-2168880 | Scavenging of heme from plasma | 3.184216e-03 | 2.497 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.905906e-03 | 2.309 |
| R-HSA-166786 | Creation of C4 and C2 activators | 4.646610e-03 | 2.333 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.507925e-03 | 2.259 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.523636e-03 | 2.258 |
| R-HSA-166663 | Initial triggering of complement | 6.000981e-03 | 2.222 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.334033e-03 | 2.198 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.334033e-03 | 2.198 |
| R-HSA-9827857 | Specification of primordial germ cells | 7.050870e-03 | 2.152 |
| R-HSA-977606 | Regulation of Complement cascade | 8.184066e-03 | 2.087 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.123931e-02 | 1.949 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.123931e-02 | 1.949 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.123931e-02 | 1.949 |
| R-HSA-6791461 | RPIA deficiency: failed conversion of RU5P to R5P | 1.123931e-02 | 1.949 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.123931e-02 | 1.949 |
| R-HSA-1299344 | TWIK-related spinal cord K+ channel (TRESK) | 1.123931e-02 | 1.949 |
| R-HSA-5659996 | RPIA deficiency: failed conversion of R5P to RU5P | 1.123931e-02 | 1.949 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.123931e-02 | 1.949 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.592265e-03 | 2.066 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 1.194295e-02 | 1.923 |
| R-HSA-6806834 | Signaling by MET | 1.387440e-02 | 1.858 |
| R-HSA-166658 | Complement cascade | 1.398284e-02 | 1.854 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.370053e-02 | 1.863 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 1.553965e-02 | 1.809 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 1.544984e-02 | 1.811 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.799289e-02 | 1.745 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.082918e-02 | 1.681 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 2.235366e-02 | 1.651 |
| R-HSA-111933 | Calmodulin induced events | 2.495686e-02 | 1.603 |
| R-HSA-111997 | CaM pathway | 2.495686e-02 | 1.603 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 2.382554e-02 | 1.623 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 2.382554e-02 | 1.623 |
| R-HSA-381042 | PERK regulates gene expression | 2.389588e-02 | 1.622 |
| R-HSA-8875878 | MET promotes cell motility | 2.713547e-02 | 1.566 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 2.786441e-02 | 1.555 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 3.334444e-02 | 1.477 |
| R-HSA-8875513 | MET interacts with TNS proteins | 2.786441e-02 | 1.555 |
| R-HSA-111996 | Ca-dependent events | 3.290126e-02 | 1.483 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.830338e-02 | 1.548 |
| R-HSA-9658195 | Leishmania infection | 2.830338e-02 | 1.548 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.657032e-02 | 1.437 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.657032e-02 | 1.437 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.755781e-02 | 1.425 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.782690e-02 | 1.422 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 4.421301e-02 | 1.354 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 4.960188e-02 | 1.305 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 5.496070e-02 | 1.260 |
| R-HSA-8875656 | MET receptor recycling | 6.028963e-02 | 1.220 |
| R-HSA-170984 | ARMS-mediated activation | 6.558885e-02 | 1.183 |
| R-HSA-9700645 | ALK mutants bind TKIs | 6.558885e-02 | 1.183 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 7.085850e-02 | 1.150 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 8.649176e-02 | 1.063 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 9.164481e-02 | 1.038 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.318474e-01 | 0.880 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.416199e-01 | 0.849 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.416199e-01 | 0.849 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 1.464653e-01 | 0.834 |
| R-HSA-72649 | Translation initiation complex formation | 4.845199e-02 | 1.315 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.125945e-02 | 1.290 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.704425e-02 | 1.244 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.152523e-02 | 1.211 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.152523e-02 | 1.211 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.842669e-01 | 0.735 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.457743e-02 | 1.190 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.612243e-02 | 1.180 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.888741e-01 | 0.724 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.888741e-01 | 0.724 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 7.083080e-02 | 1.150 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.980115e-01 | 0.703 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.980115e-01 | 0.703 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.025420e-01 | 0.693 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.727300e-02 | 1.112 |
| R-HSA-380287 | Centrosome maturation | 8.056135e-02 | 1.094 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.115270e-01 | 0.675 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.047091e-01 | 0.980 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.248741e-01 | 0.904 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.083047e-01 | 0.965 |
| R-HSA-9796292 | Formation of axial mesoderm | 9.164481e-02 | 1.038 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 8.649176e-02 | 1.063 |
| R-HSA-9620244 | Long-term potentiation | 1.608398e-01 | 0.794 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 5.496070e-02 | 1.260 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 9.676911e-02 | 1.014 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.675508e-01 | 0.776 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.675508e-01 | 0.776 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 4.421301e-02 | 1.354 |
| R-HSA-114516 | Disinhibition of SNARE formation | 5.496070e-02 | 1.260 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 6.558885e-02 | 1.183 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 7.085850e-02 | 1.150 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 9.164481e-02 | 1.038 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 1.069321e-01 | 0.971 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.416199e-01 | 0.849 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.560751e-01 | 0.807 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 1.749747e-01 | 0.757 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.169820e-01 | 0.932 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.934556e-01 | 0.713 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.025420e-01 | 0.693 |
| R-HSA-68877 | Mitotic Prometaphase | 1.189288e-01 | 0.925 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.029240e-01 | 0.987 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.169820e-01 | 0.932 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.412407e-02 | 1.267 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.587150e-02 | 1.018 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.478236e-01 | 0.830 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.478236e-01 | 0.830 |
| R-HSA-169893 | Prolonged ERK activation events | 1.069321e-01 | 0.971 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.343282e-01 | 0.872 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.842669e-01 | 0.735 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.269200e-01 | 0.896 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.416199e-01 | 0.849 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.980115e-01 | 0.703 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.070471e-01 | 0.684 |
| R-HSA-182971 | EGFR downregulation | 1.888741e-01 | 0.724 |
| R-HSA-1474165 | Reproduction | 1.999524e-01 | 0.699 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 5.496070e-02 | 1.260 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.608398e-01 | 0.794 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.608398e-01 | 0.794 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 1.749747e-01 | 0.757 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.888741e-01 | 0.724 |
| R-HSA-2028269 | Signaling by Hippo | 1.169820e-01 | 0.932 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 9.676911e-02 | 1.014 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.655778e-01 | 0.781 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.980115e-01 | 0.703 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 9.762111e-02 | 1.010 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 1.069321e-01 | 0.971 |
| R-HSA-9945266 | Differentiation of T cells | 1.069321e-01 | 0.971 |
| R-HSA-112043 | PLC beta mediated events | 5.852467e-02 | 1.233 |
| R-HSA-187687 | Signalling to ERKs | 2.115270e-01 | 0.675 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.381547e-01 | 0.860 |
| R-HSA-68882 | Mitotic Anaphase | 1.495464e-01 | 0.825 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 1.655778e-01 | 0.781 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.508742e-01 | 0.821 |
| R-HSA-68886 | M Phase | 7.861212e-02 | 1.105 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.343282e-01 | 0.872 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 7.085850e-02 | 1.150 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 9.676911e-02 | 1.014 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 8.896732e-02 | 1.051 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.608398e-01 | 0.794 |
| R-HSA-112040 | G-protein mediated events | 6.767978e-02 | 1.170 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 7.085850e-02 | 1.150 |
| R-HSA-397014 | Muscle contraction | 1.442744e-01 | 0.841 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.115270e-01 | 0.675 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.749076e-02 | 1.240 |
| R-HSA-112316 | Neuronal System | 1.437156e-01 | 0.842 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.018648e-01 | 0.992 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.219649e-01 | 0.914 |
| R-HSA-186763 | Downstream signal transduction | 1.888741e-01 | 0.724 |
| R-HSA-212436 | Generic Transcription Pathway | 5.843862e-02 | 1.233 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 9.762111e-02 | 1.010 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 1.367474e-01 | 0.864 |
| R-HSA-74160 | Gene expression (Transcription) | 9.189749e-02 | 1.037 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.980115e-01 | 0.703 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.735566e-01 | 0.761 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.816186e-01 | 0.741 |
| R-HSA-4839726 | Chromatin organization | 1.951951e-01 | 0.710 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.885285e-01 | 0.725 |
| R-HSA-111885 | Opioid Signalling | 1.381547e-01 | 0.860 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 1.464653e-01 | 0.834 |
| R-HSA-5576891 | Cardiac conduction | 2.020038e-01 | 0.695 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.318474e-01 | 0.880 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.416199e-01 | 0.849 |
| R-HSA-5673000 | RAF activation | 2.070471e-01 | 0.684 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.491957e-01 | 0.826 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.416199e-01 | 0.849 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.025420e-01 | 0.693 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.980115e-01 | 0.703 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.740051e-01 | 0.759 |
| R-HSA-3371556 | Cellular response to heat stress | 1.775802e-01 | 0.751 |
| R-HSA-191273 | Cholesterol biosynthesis | 8.557405e-02 | 1.068 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.717153e-01 | 0.765 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.655778e-01 | 0.781 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.412407e-02 | 1.267 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.980115e-01 | 0.703 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.458785e-01 | 0.836 |
| R-HSA-354192 | Integrin signaling | 1.980115e-01 | 0.703 |
| R-HSA-382556 | ABC-family proteins mediated transport | 1.305269e-01 | 0.884 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 8.389268e-02 | 1.076 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.458785e-01 | 0.836 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.423187e-02 | 1.129 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.101149e-01 | 0.958 |
| R-HSA-9833482 | PKR-mediated signaling | 8.896732e-02 | 1.051 |
| R-HSA-913531 | Interferon Signaling | 1.953497e-01 | 0.709 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 5.311891e-02 | 1.275 |
| R-HSA-109582 | Hemostasis | 1.703772e-01 | 0.769 |
| R-HSA-9679506 | SARS-CoV Infections | 1.080175e-01 | 0.967 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.159819e-01 | 0.666 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.159819e-01 | 0.666 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.159819e-01 | 0.666 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.159819e-01 | 0.666 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.204120e-01 | 0.657 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 2.204120e-01 | 0.657 |
| R-HSA-196757 | Metabolism of folate and pterines | 2.204120e-01 | 0.657 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.205688e-01 | 0.656 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.248172e-01 | 0.648 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.248172e-01 | 0.648 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.291979e-01 | 0.640 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 2.291979e-01 | 0.640 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.291979e-01 | 0.640 |
| R-HSA-71336 | Pentose phosphate pathway | 2.291979e-01 | 0.640 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.291979e-01 | 0.640 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.291979e-01 | 0.640 |
| R-HSA-1640170 | Cell Cycle | 2.304960e-01 | 0.637 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.335540e-01 | 0.632 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.335540e-01 | 0.632 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.335540e-01 | 0.632 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.335540e-01 | 0.632 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 2.335540e-01 | 0.632 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 2.335540e-01 | 0.632 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.335540e-01 | 0.632 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.335540e-01 | 0.632 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.335540e-01 | 0.632 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.378858e-01 | 0.624 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.378858e-01 | 0.624 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.381872e-01 | 0.623 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.421934e-01 | 0.616 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.421934e-01 | 0.616 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.455290e-01 | 0.610 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.464769e-01 | 0.608 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.464769e-01 | 0.608 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 2.497033e-01 | 0.603 |
| R-HSA-8854214 | TBC/RABGAPs | 2.507365e-01 | 0.601 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.549722e-01 | 0.594 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.591843e-01 | 0.586 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.591843e-01 | 0.586 |
| R-HSA-9711097 | Cellular response to starvation | 2.622389e-01 | 0.581 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.633728e-01 | 0.579 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.633728e-01 | 0.579 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.633728e-01 | 0.579 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.633728e-01 | 0.579 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.633728e-01 | 0.579 |
| R-HSA-162582 | Signal Transduction | 2.661160e-01 | 0.575 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.664197e-01 | 0.574 |
| R-HSA-9766229 | Degradation of CDH1 | 2.757983e-01 | 0.559 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.798939e-01 | 0.553 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.839666e-01 | 0.547 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.880165e-01 | 0.541 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.920437e-01 | 0.535 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.956638e-01 | 0.529 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.956638e-01 | 0.529 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.000307e-01 | 0.523 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.018163e-01 | 0.520 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.039908e-01 | 0.517 |
| R-HSA-177929 | Signaling by EGFR | 3.039908e-01 | 0.517 |
| R-HSA-5578775 | Ion homeostasis | 3.039908e-01 | 0.517 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.079286e-01 | 0.512 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.079286e-01 | 0.512 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.118445e-01 | 0.506 |
| R-HSA-191859 | snRNP Assembly | 3.157384e-01 | 0.501 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.157384e-01 | 0.501 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.196105e-01 | 0.495 |
| R-HSA-69275 | G2/M Transition | 3.226831e-01 | 0.491 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.234610e-01 | 0.490 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.234610e-01 | 0.490 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.268203e-01 | 0.486 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.272899e-01 | 0.485 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.272899e-01 | 0.485 |
| R-HSA-186797 | Signaling by PDGF | 3.272899e-01 | 0.485 |
| R-HSA-9707616 | Heme signaling | 3.272899e-01 | 0.485 |
| R-HSA-983712 | Ion channel transport | 3.288866e-01 | 0.483 |
| R-HSA-5617833 | Cilium Assembly | 3.309512e-01 | 0.480 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.310973e-01 | 0.480 |
| R-HSA-8848021 | Signaling by PTK6 | 3.310973e-01 | 0.480 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.310973e-01 | 0.480 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.348835e-01 | 0.475 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.350754e-01 | 0.475 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.423923e-01 | 0.465 |
| R-HSA-9609690 | HCMV Early Events | 3.433021e-01 | 0.464 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.433021e-01 | 0.464 |
| R-HSA-5218859 | Regulated Necrosis | 3.498173e-01 | 0.456 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.571594e-01 | 0.447 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.571594e-01 | 0.447 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.593549e-01 | 0.444 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.607996e-01 | 0.443 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.644194e-01 | 0.438 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.680190e-01 | 0.434 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.680190e-01 | 0.434 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.680190e-01 | 0.434 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 3.680190e-01 | 0.434 |
| R-HSA-1236394 | Signaling by ERBB4 | 3.715984e-01 | 0.430 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.751577e-01 | 0.426 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.778856e-01 | 0.423 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.786971e-01 | 0.422 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.798982e-01 | 0.420 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.857165e-01 | 0.414 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.857165e-01 | 0.414 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.891968e-01 | 0.410 |
| R-HSA-418990 | Adherens junctions interactions | 3.899207e-01 | 0.409 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.960989e-01 | 0.402 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.995209e-01 | 0.398 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.058089e-01 | 0.392 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.063076e-01 | 0.391 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.163457e-01 | 0.381 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.248761e-01 | 0.372 |
| R-HSA-8939211 | ESR-mediated signaling | 4.273332e-01 | 0.369 |
| R-HSA-1266738 | Developmental Biology | 4.360315e-01 | 0.360 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.454635e-01 | 0.351 |
| R-HSA-9609646 | HCMV Infection | 4.522473e-01 | 0.345 |
| R-HSA-421270 | Cell-cell junction organization | 4.541390e-01 | 0.343 |
| R-HSA-1296071 | Potassium Channels | 4.548465e-01 | 0.342 |
| R-HSA-157579 | Telomere Maintenance | 4.579391e-01 | 0.339 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.640724e-01 | 0.333 |
| R-HSA-70171 | Glycolysis | 4.671132e-01 | 0.331 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.701370e-01 | 0.328 |
| R-HSA-1483255 | PI Metabolism | 4.731439e-01 | 0.325 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.731439e-01 | 0.325 |
| R-HSA-9824446 | Viral Infection Pathways | 4.743301e-01 | 0.324 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.791070e-01 | 0.320 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.791070e-01 | 0.320 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.836180e-01 | 0.315 |
| R-HSA-211000 | Gene Silencing by RNA | 4.908337e-01 | 0.309 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.909292e-01 | 0.309 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.937243e-01 | 0.307 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.966037e-01 | 0.304 |
| R-HSA-446728 | Cell junction organization | 5.037770e-01 | 0.298 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.051254e-01 | 0.297 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.107304e-01 | 0.292 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.190203e-01 | 0.285 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.231663e-01 | 0.281 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.244696e-01 | 0.280 |
| R-HSA-70326 | Glucose metabolism | 5.244696e-01 | 0.280 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.244696e-01 | 0.280 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.271713e-01 | 0.278 |
| R-HSA-68875 | Mitotic Prophase | 5.325292e-01 | 0.274 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.335302e-01 | 0.273 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.351857e-01 | 0.271 |
| R-HSA-73886 | Chromosome Maintenance | 5.351857e-01 | 0.271 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.352428e-01 | 0.271 |
| R-HSA-2262752 | Cellular responses to stress | 5.382462e-01 | 0.269 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.404538e-01 | 0.267 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.430656e-01 | 0.265 |
| R-HSA-194138 | Signaling by VEGF | 5.482454e-01 | 0.261 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.559064e-01 | 0.255 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.609421e-01 | 0.251 |
| R-HSA-1280218 | Adaptive Immune System | 5.647507e-01 | 0.248 |
| R-HSA-9843745 | Adipogenesis | 5.659214e-01 | 0.247 |
| R-HSA-9909396 | Circadian clock | 5.683901e-01 | 0.245 |
| R-HSA-1500931 | Cell-Cell communication | 5.685981e-01 | 0.245 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.708449e-01 | 0.243 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.798646e-01 | 0.237 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.798646e-01 | 0.237 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.805266e-01 | 0.236 |
| R-HSA-8957322 | Metabolism of steroids | 5.814566e-01 | 0.235 |
| R-HSA-6807070 | PTEN Regulation | 5.876459e-01 | 0.231 |
| R-HSA-1632852 | Macroautophagy | 5.923256e-01 | 0.227 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.969527e-01 | 0.224 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.969527e-01 | 0.224 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.992467e-01 | 0.222 |
| R-HSA-166520 | Signaling by NTRKs | 6.105247e-01 | 0.214 |
| R-HSA-69242 | S Phase | 6.105247e-01 | 0.214 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.168698e-01 | 0.210 |
| R-HSA-73887 | Death Receptor Signaling | 6.236445e-01 | 0.205 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.257882e-01 | 0.204 |
| R-HSA-9612973 | Autophagy | 6.279199e-01 | 0.202 |
| R-HSA-9610379 | HCMV Late Events | 6.300395e-01 | 0.201 |
| R-HSA-162587 | HIV Life Cycle | 6.300395e-01 | 0.201 |
| R-HSA-877300 | Interferon gamma signaling | 6.342431e-01 | 0.198 |
| R-HSA-5663205 | Infectious disease | 6.407561e-01 | 0.193 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.445463e-01 | 0.191 |
| R-HSA-5619102 | SLC transporter disorders | 6.505900e-01 | 0.187 |
| R-HSA-72306 | tRNA processing | 6.584903e-01 | 0.181 |
| R-HSA-418555 | G alpha (s) signalling events | 6.604376e-01 | 0.180 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.623740e-01 | 0.179 |
| R-HSA-388396 | GPCR downstream signalling | 6.628593e-01 | 0.179 |
| R-HSA-382551 | Transport of small molecules | 6.751872e-01 | 0.171 |
| R-HSA-168255 | Influenza Infection | 6.756259e-01 | 0.170 |
| R-HSA-2559583 | Cellular Senescence | 6.774766e-01 | 0.169 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.829661e-01 | 0.166 |
| R-HSA-418594 | G alpha (i) signalling events | 6.997128e-01 | 0.155 |
| R-HSA-449147 | Signaling by Interleukins | 7.119573e-01 | 0.148 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.123723e-01 | 0.147 |
| R-HSA-5357801 | Programmed Cell Death | 7.220930e-01 | 0.141 |
| R-HSA-72766 | Translation | 7.257769e-01 | 0.139 |
| R-HSA-199991 | Membrane Trafficking | 7.341004e-01 | 0.134 |
| R-HSA-372790 | Signaling by GPCR | 7.373791e-01 | 0.132 |
| R-HSA-8951664 | Neddylation | 7.464551e-01 | 0.127 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.541223e-01 | 0.123 |
| R-HSA-162906 | HIV Infection | 7.550357e-01 | 0.122 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.564376e-01 | 0.121 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.592176e-01 | 0.120 |
| R-HSA-1643685 | Disease | 7.601935e-01 | 0.119 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.643431e-01 | 0.117 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.816155e-01 | 0.107 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.926258e-01 | 0.101 |
| R-HSA-168256 | Immune System | 8.171086e-01 | 0.088 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.183310e-01 | 0.087 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.214425e-01 | 0.085 |
| R-HSA-1483257 | Phospholipid metabolism | 8.343278e-01 | 0.079 |
| R-HSA-195721 | Signaling by WNT | 8.371682e-01 | 0.077 |
| R-HSA-597592 | Post-translational protein modification | 8.490991e-01 | 0.071 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.787047e-01 | 0.056 |
| R-HSA-168249 | Innate Immune System | 8.877286e-01 | 0.052 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.887887e-01 | 0.051 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.009549e-01 | 0.045 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.048942e-01 | 0.043 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.086784e-01 | 0.042 |
| R-HSA-5668914 | Diseases of metabolism | 9.232795e-01 | 0.035 |
| R-HSA-392499 | Metabolism of proteins | 9.442354e-01 | 0.025 |
| R-HSA-9675108 | Nervous system development | 9.689782e-01 | 0.014 |
| R-HSA-556833 | Metabolism of lipids | 9.929973e-01 | 0.003 |
| R-HSA-8953854 | Metabolism of RNA | 9.930616e-01 | 0.003 |
| R-HSA-1430728 | Metabolism | 9.999955e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.775 | 0.183 | 2 | 0.786 |
KIS |
0.769 | 0.200 | 1 | 0.654 |
GRK1 |
0.766 | 0.321 | -2 | 0.501 |
CLK3 |
0.762 | 0.092 | 1 | 0.812 |
MOS |
0.761 | 0.237 | 1 | 0.848 |
PIM3 |
0.761 | 0.068 | -3 | 0.802 |
NDR2 |
0.758 | 0.052 | -3 | 0.793 |
AURC |
0.756 | 0.024 | -2 | 0.241 |
RSK2 |
0.755 | 0.053 | -3 | 0.749 |
GCN2 |
0.755 | 0.010 | 2 | 0.756 |
SRPK1 |
0.753 | 0.072 | -3 | 0.746 |
CK1E |
0.752 | 0.251 | -3 | 0.676 |
HIPK4 |
0.752 | 0.059 | 1 | 0.805 |
CDC7 |
0.751 | 0.025 | 1 | 0.786 |
CDKL1 |
0.751 | 0.071 | -3 | 0.758 |
PIM1 |
0.751 | 0.067 | -3 | 0.773 |
TGFBR2 |
0.751 | 0.041 | -2 | 0.359 |
SKMLCK |
0.750 | 0.073 | -2 | 0.337 |
IKKB |
0.750 | -0.019 | -2 | 0.295 |
CDKL5 |
0.750 | 0.065 | -3 | 0.751 |
PRKD2 |
0.750 | 0.060 | -3 | 0.731 |
PKACG |
0.749 | 0.023 | -2 | 0.276 |
PRKX |
0.749 | 0.062 | -3 | 0.709 |
NDR1 |
0.749 | 0.017 | -3 | 0.783 |
PKACB |
0.749 | 0.039 | -2 | 0.241 |
GRK4 |
0.748 | 0.187 | -2 | 0.449 |
CAMK1B |
0.748 | 0.032 | -3 | 0.789 |
GRK7 |
0.748 | 0.209 | 1 | 0.725 |
GRK5 |
0.748 | 0.071 | -3 | 0.782 |
NLK |
0.747 | 0.049 | 1 | 0.790 |
CK1D |
0.747 | 0.257 | -3 | 0.636 |
ERK5 |
0.747 | 0.053 | 1 | 0.810 |
PRKD1 |
0.747 | 0.044 | -3 | 0.757 |
PRPK |
0.747 | -0.024 | -1 | 0.756 |
PKN2 |
0.746 | 0.052 | -3 | 0.780 |
P90RSK |
0.746 | 0.033 | -3 | 0.751 |
BMPR1B |
0.746 | 0.146 | 1 | 0.750 |
NUAK2 |
0.745 | 0.046 | -3 | 0.798 |
MTOR |
0.745 | -0.035 | 1 | 0.738 |
DSTYK |
0.745 | 0.049 | 2 | 0.813 |
CAMK2G |
0.743 | -0.005 | 2 | 0.714 |
WNK1 |
0.743 | 0.020 | -2 | 0.322 |
MST4 |
0.743 | 0.036 | 2 | 0.782 |
RSK3 |
0.743 | 0.014 | -3 | 0.731 |
SRPK2 |
0.743 | 0.058 | -3 | 0.679 |
MLK1 |
0.742 | 0.041 | 2 | 0.764 |
CAMLCK |
0.742 | 0.015 | -2 | 0.313 |
BMPR2 |
0.742 | -0.013 | -2 | 0.347 |
RAF1 |
0.742 | -0.044 | 1 | 0.789 |
MAPKAPK3 |
0.741 | 0.023 | -3 | 0.727 |
PKN3 |
0.741 | 0.026 | -3 | 0.762 |
MAPKAPK2 |
0.741 | 0.036 | -3 | 0.708 |
AURB |
0.740 | 0.001 | -2 | 0.236 |
SRPK3 |
0.740 | 0.062 | -3 | 0.715 |
PKCD |
0.740 | 0.020 | 2 | 0.744 |
CHAK2 |
0.739 | 0.013 | -1 | 0.688 |
MLK3 |
0.739 | 0.041 | 2 | 0.716 |
ATR |
0.739 | -0.028 | 1 | 0.777 |
NIK |
0.739 | 0.007 | -3 | 0.790 |
RSK4 |
0.739 | 0.049 | -3 | 0.736 |
LATS2 |
0.739 | -0.010 | -5 | 0.719 |
GRK6 |
0.739 | 0.052 | 1 | 0.782 |
AURA |
0.739 | -0.002 | -2 | 0.238 |
CK1A2 |
0.738 | 0.202 | -3 | 0.641 |
CAMK2B |
0.738 | 0.039 | 2 | 0.708 |
CLK4 |
0.738 | 0.044 | -3 | 0.760 |
PKG2 |
0.738 | 0.009 | -2 | 0.238 |
ICK |
0.738 | 0.020 | -3 | 0.782 |
GRK2 |
0.738 | 0.104 | -2 | 0.385 |
PAK1 |
0.737 | -0.009 | -2 | 0.288 |
GRK3 |
0.737 | 0.136 | -2 | 0.410 |
P70S6KB |
0.737 | 0.009 | -3 | 0.753 |
RIPK3 |
0.737 | 0.017 | 3 | 0.632 |
CAMK2A |
0.737 | 0.039 | 2 | 0.719 |
CAMK2D |
0.737 | -0.016 | -3 | 0.752 |
TGFBR1 |
0.737 | 0.065 | -2 | 0.370 |
DAPK2 |
0.737 | 0.007 | -3 | 0.790 |
CLK2 |
0.737 | 0.071 | -3 | 0.754 |
PDHK4 |
0.736 | -0.168 | 1 | 0.803 |
NEK6 |
0.736 | -0.065 | -2 | 0.321 |
AMPKA1 |
0.736 | 0.010 | -3 | 0.792 |
PRKD3 |
0.736 | 0.055 | -3 | 0.711 |
ULK2 |
0.735 | -0.125 | 2 | 0.714 |
MNK2 |
0.735 | -0.006 | -2 | 0.256 |
MYLK4 |
0.735 | 0.034 | -2 | 0.299 |
FAM20C |
0.735 | 0.020 | 2 | 0.529 |
IKKA |
0.735 | -0.025 | -2 | 0.294 |
NEK7 |
0.735 | -0.068 | -3 | 0.715 |
PKCB |
0.735 | 0.038 | 2 | 0.698 |
MSK1 |
0.734 | 0.021 | -3 | 0.723 |
PKACA |
0.734 | 0.023 | -2 | 0.217 |
AKT2 |
0.734 | 0.048 | -3 | 0.693 |
IKKE |
0.733 | -0.095 | 1 | 0.657 |
TBK1 |
0.733 | -0.097 | 1 | 0.663 |
CK1G1 |
0.733 | 0.157 | -3 | 0.670 |
MLK2 |
0.733 | -0.022 | 2 | 0.777 |
ALK4 |
0.733 | 0.054 | -2 | 0.370 |
DYRK2 |
0.733 | 0.025 | 1 | 0.669 |
CAMK4 |
0.732 | -0.007 | -3 | 0.760 |
MSK2 |
0.732 | 0.001 | -3 | 0.724 |
RIPK1 |
0.732 | 0.027 | 1 | 0.832 |
IRE1 |
0.732 | 0.013 | 1 | 0.859 |
PAK3 |
0.732 | -0.038 | -2 | 0.276 |
PIM2 |
0.731 | 0.045 | -3 | 0.720 |
MASTL |
0.731 | -0.090 | -2 | 0.310 |
MARK4 |
0.731 | -0.054 | 4 | 0.723 |
PKCG |
0.731 | 0.011 | 2 | 0.698 |
LATS1 |
0.731 | 0.018 | -3 | 0.801 |
HUNK |
0.731 | -0.017 | 2 | 0.721 |
AMPKA2 |
0.731 | 0.004 | -3 | 0.772 |
PKCA |
0.730 | 0.014 | 2 | 0.703 |
HIPK2 |
0.730 | 0.054 | 1 | 0.589 |
DLK |
0.730 | -0.022 | 1 | 0.784 |
ALK2 |
0.730 | 0.087 | -2 | 0.392 |
CLK1 |
0.730 | 0.037 | -3 | 0.725 |
TTBK2 |
0.729 | 0.059 | 2 | 0.612 |
ACVR2A |
0.729 | 0.026 | -2 | 0.342 |
ACVR2B |
0.729 | 0.037 | -2 | 0.355 |
TSSK2 |
0.729 | -0.014 | -5 | 0.816 |
PKR |
0.729 | 0.045 | 1 | 0.875 |
HIPK1 |
0.728 | 0.060 | 1 | 0.691 |
NEK9 |
0.728 | -0.091 | 2 | 0.768 |
MLK4 |
0.728 | 0.016 | 2 | 0.705 |
PAK6 |
0.728 | -0.023 | -2 | 0.230 |
SGK3 |
0.728 | 0.023 | -3 | 0.738 |
MNK1 |
0.727 | -0.015 | -2 | 0.269 |
TSSK1 |
0.727 | -0.011 | -3 | 0.806 |
MPSK1 |
0.727 | 0.155 | 1 | 0.842 |
PDHK1 |
0.727 | -0.223 | 1 | 0.779 |
BMPR1A |
0.726 | 0.074 | 1 | 0.715 |
PKCZ |
0.726 | -0.000 | 2 | 0.727 |
WNK3 |
0.726 | -0.121 | 1 | 0.801 |
PHKG1 |
0.726 | -0.009 | -3 | 0.777 |
PKCH |
0.726 | 0.006 | 2 | 0.687 |
ATM |
0.726 | -0.009 | 1 | 0.690 |
CDK1 |
0.725 | 0.030 | 1 | 0.591 |
MELK |
0.725 | -0.013 | -3 | 0.749 |
GSK3A |
0.725 | 0.101 | 4 | 0.556 |
PAK2 |
0.725 | -0.039 | -2 | 0.283 |
BCKDK |
0.724 | -0.120 | -1 | 0.696 |
BRSK1 |
0.724 | -0.008 | -3 | 0.745 |
GSK3B |
0.724 | 0.090 | 4 | 0.550 |
QIK |
0.724 | -0.038 | -3 | 0.754 |
ANKRD3 |
0.724 | -0.052 | 1 | 0.830 |
CDK18 |
0.724 | 0.014 | 1 | 0.567 |
CDK7 |
0.724 | -0.017 | 1 | 0.629 |
CDK8 |
0.723 | -0.030 | 1 | 0.594 |
YSK4 |
0.723 | -0.050 | 1 | 0.726 |
PLK1 |
0.723 | -0.063 | -2 | 0.304 |
ULK1 |
0.722 | -0.139 | -3 | 0.668 |
PASK |
0.722 | 0.102 | -3 | 0.809 |
MEK1 |
0.722 | -0.042 | 2 | 0.755 |
NIM1 |
0.722 | -0.068 | 3 | 0.653 |
NUAK1 |
0.722 | -0.027 | -3 | 0.738 |
MST3 |
0.722 | 0.084 | 2 | 0.773 |
PERK |
0.722 | 0.029 | -2 | 0.365 |
SIK |
0.722 | -0.018 | -3 | 0.720 |
QSK |
0.722 | -0.031 | 4 | 0.691 |
IRE2 |
0.721 | -0.038 | 2 | 0.692 |
CAMK1G |
0.721 | 0.026 | -3 | 0.719 |
SMG1 |
0.721 | -0.010 | 1 | 0.722 |
TLK2 |
0.721 | -0.033 | 1 | 0.772 |
P38A |
0.721 | 0.001 | 1 | 0.687 |
AKT1 |
0.720 | 0.025 | -3 | 0.708 |
DRAK1 |
0.720 | 0.002 | 1 | 0.770 |
P38B |
0.720 | 0.009 | 1 | 0.599 |
MEKK3 |
0.719 | 0.096 | 1 | 0.769 |
BRSK2 |
0.718 | -0.036 | -3 | 0.747 |
DCAMKL1 |
0.718 | -0.006 | -3 | 0.760 |
JNK2 |
0.717 | 0.018 | 1 | 0.560 |
CDK19 |
0.717 | -0.028 | 1 | 0.551 |
PKCE |
0.717 | 0.038 | 2 | 0.692 |
HIPK3 |
0.717 | 0.025 | 1 | 0.688 |
DNAPK |
0.717 | -0.025 | 1 | 0.612 |
CK1A |
0.716 | 0.205 | -3 | 0.573 |
CK2A2 |
0.716 | 0.059 | 1 | 0.709 |
DYRK3 |
0.716 | 0.020 | 1 | 0.699 |
CDK5 |
0.716 | -0.003 | 1 | 0.656 |
DYRK4 |
0.716 | 0.016 | 1 | 0.581 |
CDK2 |
0.716 | 0.017 | 1 | 0.672 |
MAPKAPK5 |
0.716 | -0.029 | -3 | 0.675 |
DYRK1A |
0.716 | 0.008 | 1 | 0.711 |
TLK1 |
0.716 | 0.029 | -2 | 0.388 |
AKT3 |
0.716 | 0.035 | -3 | 0.652 |
PRP4 |
0.716 | 0.047 | -3 | 0.758 |
CHAK1 |
0.715 | -0.068 | 2 | 0.722 |
PKCI |
0.715 | -0.005 | 2 | 0.698 |
JNK3 |
0.715 | 0.007 | 1 | 0.601 |
CDK13 |
0.715 | -0.036 | 1 | 0.601 |
PKCT |
0.715 | -0.010 | 2 | 0.693 |
MEKK2 |
0.714 | 0.035 | 2 | 0.749 |
HRI |
0.714 | -0.069 | -2 | 0.334 |
SMMLCK |
0.714 | -0.003 | -3 | 0.754 |
CHK1 |
0.714 | -0.047 | -3 | 0.733 |
VRK2 |
0.714 | -0.118 | 1 | 0.832 |
MAK |
0.714 | 0.046 | -2 | 0.258 |
PAK5 |
0.713 | -0.042 | -2 | 0.217 |
P70S6K |
0.713 | -0.005 | -3 | 0.676 |
MEK5 |
0.713 | -0.038 | 2 | 0.751 |
CDK3 |
0.712 | 0.031 | 1 | 0.527 |
MARK3 |
0.712 | -0.055 | 4 | 0.650 |
CDK17 |
0.712 | -0.003 | 1 | 0.509 |
ERK1 |
0.712 | -0.004 | 1 | 0.586 |
TAO3 |
0.712 | 0.017 | 1 | 0.771 |
NEK2 |
0.712 | -0.120 | 2 | 0.739 |
BUB1 |
0.711 | 0.105 | -5 | 0.813 |
PAK4 |
0.711 | -0.037 | -2 | 0.220 |
CAMK1D |
0.711 | 0.023 | -3 | 0.667 |
CDK10 |
0.711 | 0.017 | 1 | 0.600 |
DAPK3 |
0.711 | 0.021 | -3 | 0.773 |
SGK1 |
0.711 | 0.040 | -3 | 0.636 |
P38G |
0.711 | -0.002 | 1 | 0.497 |
PLK3 |
0.711 | -0.090 | 2 | 0.655 |
CDK14 |
0.710 | 0.004 | 1 | 0.607 |
DYRK1B |
0.710 | -0.001 | 1 | 0.624 |
CK2A1 |
0.709 | 0.063 | 1 | 0.693 |
ZAK |
0.709 | -0.042 | 1 | 0.726 |
CDK12 |
0.709 | -0.031 | 1 | 0.571 |
GAK |
0.709 | 0.108 | 1 | 0.841 |
DAPK1 |
0.709 | 0.029 | -3 | 0.765 |
DCAMKL2 |
0.708 | -0.028 | -3 | 0.760 |
WNK4 |
0.708 | -0.069 | -2 | 0.308 |
IRAK4 |
0.708 | -0.044 | 1 | 0.831 |
MARK2 |
0.708 | -0.069 | 4 | 0.633 |
ERK7 |
0.708 | 0.028 | 2 | 0.550 |
PLK4 |
0.708 | -0.075 | 2 | 0.533 |
MRCKB |
0.707 | 0.022 | -3 | 0.710 |
SNRK |
0.707 | -0.111 | 2 | 0.583 |
CDK9 |
0.707 | -0.045 | 1 | 0.604 |
ERK2 |
0.706 | -0.019 | 1 | 0.642 |
CHK2 |
0.706 | 0.047 | -3 | 0.645 |
NEK5 |
0.706 | -0.069 | 1 | 0.828 |
CDK16 |
0.706 | 0.002 | 1 | 0.525 |
PINK1 |
0.705 | -0.123 | 1 | 0.870 |
TAK1 |
0.705 | 0.088 | 1 | 0.791 |
ROCK2 |
0.705 | 0.030 | -3 | 0.761 |
MEKK1 |
0.705 | -0.096 | 1 | 0.763 |
BRAF |
0.705 | -0.069 | -4 | 0.746 |
PKN1 |
0.705 | 0.012 | -3 | 0.695 |
MOK |
0.705 | 0.049 | 1 | 0.752 |
SSTK |
0.704 | -0.054 | 4 | 0.683 |
GCK |
0.704 | 0.045 | 1 | 0.771 |
MARK1 |
0.703 | -0.079 | 4 | 0.665 |
PHKG2 |
0.703 | -0.066 | -3 | 0.745 |
MRCKA |
0.703 | 0.009 | -3 | 0.722 |
HPK1 |
0.703 | 0.037 | 1 | 0.751 |
P38D |
0.703 | -0.015 | 1 | 0.500 |
CAMK1A |
0.702 | 0.031 | -3 | 0.646 |
TAO2 |
0.701 | -0.040 | 2 | 0.772 |
DMPK1 |
0.701 | 0.042 | -3 | 0.741 |
NEK8 |
0.701 | -0.051 | 2 | 0.741 |
TNIK |
0.700 | 0.008 | 3 | 0.796 |
PKG1 |
0.700 | -0.023 | -2 | 0.200 |
CAMKK1 |
0.700 | -0.111 | -2 | 0.266 |
LKB1 |
0.700 | -0.041 | -3 | 0.724 |
NEK11 |
0.699 | -0.020 | 1 | 0.760 |
TTBK1 |
0.699 | -0.034 | 2 | 0.519 |
PDK1 |
0.698 | -0.032 | 1 | 0.791 |
EEF2K |
0.698 | 0.000 | 3 | 0.759 |
SLK |
0.697 | -0.048 | -2 | 0.262 |
SBK |
0.697 | 0.033 | -3 | 0.591 |
HGK |
0.697 | -0.039 | 3 | 0.788 |
MINK |
0.696 | -0.008 | 1 | 0.759 |
LRRK2 |
0.696 | -0.037 | 2 | 0.752 |
JNK1 |
0.696 | 0.001 | 1 | 0.552 |
LOK |
0.696 | -0.057 | -2 | 0.256 |
MST2 |
0.696 | -0.027 | 1 | 0.750 |
CAMKK2 |
0.694 | -0.130 | -2 | 0.251 |
MEKK6 |
0.693 | -0.042 | 1 | 0.765 |
KHS2 |
0.693 | 0.024 | 1 | 0.759 |
ROCK1 |
0.692 | 0.016 | -3 | 0.726 |
IRAK1 |
0.692 | -0.140 | -1 | 0.683 |
STK33 |
0.691 | -0.074 | 2 | 0.546 |
PLK2 |
0.691 | -0.038 | -3 | 0.649 |
CRIK |
0.690 | 0.027 | -3 | 0.697 |
VRK1 |
0.690 | -0.039 | 2 | 0.743 |
PBK |
0.690 | -0.006 | 1 | 0.779 |
CDK6 |
0.690 | -0.020 | 1 | 0.584 |
KHS1 |
0.690 | -0.018 | 1 | 0.739 |
MAP3K15 |
0.689 | -0.042 | 1 | 0.720 |
NEK4 |
0.688 | -0.118 | 1 | 0.776 |
HASPIN |
0.688 | 0.033 | -1 | 0.562 |
NEK1 |
0.687 | -0.097 | 1 | 0.808 |
CDK4 |
0.686 | -0.031 | 1 | 0.559 |
MST1 |
0.686 | -0.053 | 1 | 0.754 |
CK1G3 |
0.685 | 0.159 | -3 | 0.536 |
OSR1 |
0.685 | -0.002 | 2 | 0.749 |
TTK |
0.685 | 0.013 | -2 | 0.352 |
YSK1 |
0.685 | -0.063 | 2 | 0.748 |
YANK3 |
0.684 | -0.004 | 2 | 0.324 |
CK1G2 |
0.683 | 0.191 | -3 | 0.605 |
PDHK3_TYR |
0.681 | 0.070 | 4 | 0.807 |
MYO3B |
0.680 | -0.019 | 2 | 0.752 |
MEK2 |
0.677 | -0.182 | 2 | 0.728 |
RIPK2 |
0.677 | -0.151 | 1 | 0.690 |
PDHK4_TYR |
0.674 | 0.075 | 2 | 0.789 |
MYO3A |
0.674 | -0.043 | 1 | 0.785 |
MAP2K4_TYR |
0.674 | 0.001 | -1 | 0.776 |
MAP2K6_TYR |
0.673 | 0.035 | -1 | 0.769 |
BMPR2_TYR |
0.673 | 0.060 | -1 | 0.762 |
TESK1_TYR |
0.672 | -0.020 | 3 | 0.784 |
NEK3 |
0.671 | -0.152 | 1 | 0.733 |
BIKE |
0.669 | -0.009 | 1 | 0.714 |
TAO1 |
0.669 | -0.075 | 1 | 0.690 |
PDHK1_TYR |
0.669 | 0.030 | -1 | 0.771 |
ALPHAK3 |
0.669 | 0.012 | -1 | 0.663 |
MAP2K7_TYR |
0.667 | -0.127 | 2 | 0.762 |
LIMK2_TYR |
0.667 | -0.051 | -3 | 0.771 |
PKMYT1_TYR |
0.666 | -0.056 | 3 | 0.758 |
ASK1 |
0.666 | -0.091 | 1 | 0.696 |
PINK1_TYR |
0.666 | -0.092 | 1 | 0.830 |
YANK2 |
0.660 | -0.007 | 2 | 0.357 |
FGR |
0.659 | 0.032 | 1 | 0.823 |
TXK |
0.658 | 0.072 | 1 | 0.782 |
EPHA6 |
0.658 | -0.018 | -1 | 0.736 |
LIMK1_TYR |
0.657 | -0.141 | 2 | 0.759 |
TNK2 |
0.656 | 0.015 | 3 | 0.690 |
ABL2 |
0.656 | 0.003 | -1 | 0.732 |
RET |
0.655 | -0.119 | 1 | 0.766 |
ABL1 |
0.654 | -0.002 | -1 | 0.733 |
AAK1 |
0.654 | 0.006 | 1 | 0.623 |
EPHB4 |
0.653 | -0.034 | -1 | 0.737 |
MST1R |
0.653 | -0.076 | 3 | 0.718 |
STLK3 |
0.652 | -0.126 | 1 | 0.694 |
CSF1R |
0.652 | -0.061 | 3 | 0.701 |
TYRO3 |
0.652 | -0.082 | 3 | 0.703 |
TYK2 |
0.651 | -0.154 | 1 | 0.754 |
WEE1_TYR |
0.651 | 0.008 | -1 | 0.683 |
DDR1 |
0.650 | -0.141 | 4 | 0.732 |
LCK |
0.650 | 0.035 | -1 | 0.771 |
YES1 |
0.650 | -0.031 | -1 | 0.761 |
SRMS |
0.649 | -0.011 | 1 | 0.766 |
INSRR |
0.648 | -0.043 | 3 | 0.646 |
JAK2 |
0.648 | -0.139 | 1 | 0.740 |
ROS1 |
0.648 | -0.110 | 3 | 0.670 |
HCK |
0.647 | -0.016 | -1 | 0.776 |
FER |
0.647 | -0.063 | 1 | 0.786 |
MET |
0.646 | 0.026 | 3 | 0.698 |
KIT |
0.645 | -0.056 | 3 | 0.702 |
ITK |
0.645 | -0.033 | -1 | 0.763 |
JAK3 |
0.645 | -0.097 | 1 | 0.740 |
KDR |
0.645 | -0.056 | 3 | 0.664 |
BLK |
0.645 | 0.030 | -1 | 0.754 |
EPHA4 |
0.644 | -0.049 | 2 | 0.663 |
FLT1 |
0.644 | -0.027 | -1 | 0.729 |
FYN |
0.643 | 0.053 | -1 | 0.744 |
NEK10_TYR |
0.643 | -0.105 | 1 | 0.664 |
MERTK |
0.643 | -0.032 | 3 | 0.675 |
SYK |
0.643 | 0.145 | -1 | 0.681 |
BMX |
0.643 | -0.002 | -1 | 0.688 |
FGFR2 |
0.642 | -0.102 | 3 | 0.695 |
PDGFRB |
0.642 | -0.120 | 3 | 0.707 |
TNNI3K_TYR |
0.642 | -0.077 | 1 | 0.772 |
FLT3 |
0.642 | -0.084 | 3 | 0.703 |
EPHB1 |
0.641 | -0.073 | 1 | 0.751 |
TNK1 |
0.640 | -0.118 | 3 | 0.683 |
TEC |
0.639 | -0.015 | -1 | 0.706 |
PTK2 |
0.639 | 0.060 | -1 | 0.685 |
BTK |
0.639 | -0.062 | -1 | 0.754 |
JAK1 |
0.638 | -0.092 | 1 | 0.676 |
EPHB2 |
0.638 | -0.053 | -1 | 0.731 |
EPHB3 |
0.638 | -0.086 | -1 | 0.727 |
AXL |
0.637 | -0.102 | 3 | 0.667 |
DDR2 |
0.636 | -0.071 | 3 | 0.649 |
PTK2B |
0.636 | -0.004 | -1 | 0.720 |
ERBB2 |
0.636 | -0.038 | 1 | 0.696 |
LTK |
0.635 | -0.092 | 3 | 0.660 |
PDGFRA |
0.633 | -0.163 | 3 | 0.710 |
FGFR3 |
0.633 | -0.081 | 3 | 0.668 |
MATK |
0.633 | -0.047 | -1 | 0.637 |
FRK |
0.633 | -0.034 | -1 | 0.779 |
ALK |
0.633 | -0.100 | 3 | 0.634 |
FGFR1 |
0.632 | -0.143 | 3 | 0.664 |
EPHA3 |
0.632 | -0.079 | 2 | 0.639 |
PTK6 |
0.631 | -0.146 | -1 | 0.698 |
ZAP70 |
0.631 | 0.105 | -1 | 0.608 |
LYN |
0.630 | -0.044 | 3 | 0.612 |
SRC |
0.630 | -0.001 | -1 | 0.733 |
NTRK1 |
0.630 | -0.146 | -1 | 0.727 |
TEK |
0.630 | -0.146 | 3 | 0.641 |
EPHA7 |
0.629 | -0.087 | 2 | 0.662 |
NTRK3 |
0.628 | -0.092 | -1 | 0.685 |
EPHA1 |
0.627 | -0.105 | 3 | 0.678 |
FLT4 |
0.627 | -0.137 | 3 | 0.656 |
EGFR |
0.626 | -0.039 | 1 | 0.592 |
EPHA5 |
0.626 | -0.060 | 2 | 0.649 |
FGFR4 |
0.625 | -0.063 | -1 | 0.684 |
NTRK2 |
0.624 | -0.162 | 3 | 0.641 |
CSK |
0.624 | -0.113 | 2 | 0.663 |
INSR |
0.623 | -0.134 | 3 | 0.624 |
EPHA8 |
0.622 | -0.067 | -1 | 0.695 |
ERBB4 |
0.617 | 0.009 | 1 | 0.590 |
MUSK |
0.615 | -0.105 | 1 | 0.614 |
EPHA2 |
0.614 | -0.082 | -1 | 0.687 |
IGF1R |
0.611 | -0.106 | 3 | 0.556 |
FES |
0.605 | -0.066 | -1 | 0.659 |