Motif 394 (n=149)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1595 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NMY6 | ANXA2P2 | S22 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A7KAX9 | ARHGAP32 | S1089 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| O00567 | NOP56 | S504 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14544 | SOCS6 | S72 | ochoa | Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}. |
| O14617 | AP3D1 | S636 | ochoa | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}. |
| O14640 | DVL1 | S604 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14646 | CHD1 | S1406 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14686 | KMT2D | S1834 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14715 | RGPD8 | S1594 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15063 | GARRE1 | S359 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
| O43752 | STX6 | S133 | ochoa | Syntaxin-6 | SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}. |
| O43852 | CALU | S69 | ochoa | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| O60508 | CDC40 | S26 | ochoa | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}. |
| O60551 | NMT2 | S70 | ochoa | Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Protein-lysine myristoyltransferase NMT2) (EC 2.3.1.-) (Type II N-myristoyltransferase) | Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017). {ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:9506952}. |
| O60832 | DKC1 | S422 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O75044 | SRGAP2 | S905 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75665 | OFD1 | S973 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O95208 | EPN2 | S182 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| O95239 | KIF4A | S812 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95297 | MPZL1 | S208 | ochoa | Myelin protein zero-like protein 1 (Protein zero-related) | Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}. |
| O95365 | ZBTB7A | S341 | ochoa | Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A) | Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149). {ECO:0000250|UniProtKB:O88939, ECO:0000250|UniProtKB:Q9QZ48, ECO:0000269|PubMed:12004059, ECO:0000269|PubMed:14701838, ECO:0000269|PubMed:17595526, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:24514149, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:26455326, ECO:0000269|PubMed:26816381}. |
| O95674 | CDS2 | S37 | ochoa | Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) | Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}. |
| O95684 | CEP43 | S209 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O95810 | CAVIN2 | S226 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P05783 | KRT18 | S401 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06748 | NPM1 | S227 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07355 | ANXA2 | S22 | ochoa|psp | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P08172 | CHRM2 | S290 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P08195 | SLC3A2 | S410 | psp | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P0DJD0 | RGPD1 | S1579 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1587 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P21728 | DRD1 | S263 | psp | D(1A) dopamine receptor (Dopamine D1 receptor) | Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| P21730 | C5AR1 | S327 | ochoa|psp | C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
| P23759 | PAX7 | S207 | ochoa | Paired box protein Pax-7 (HuP1) | Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. {ECO:0000269|PubMed:31092906}. |
| P30304 | CDC25A | S283 | ochoa|psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30414 | NKTR | S1207 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P42261 | GRIA1 | S836 | psp | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1311100, PubMed:20805473, PubMed:21172611, PubMed:28628100, PubMed:35675825). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (PubMed:21172611). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:1311100, ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:28628100, ECO:0000269|PubMed:35675825}. |
| P45974 | USP5 | S787 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46013 | MKI67 | S325 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49792 | RANBP2 | S2570 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51114 | FXR1 | S413 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P52701 | MSH6 | S256 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P52948 | NUP98 | S683 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54259 | ATN1 | S43 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P54578 | USP14 | S232 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P63104 | YWHAZ | S114 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P78352 | DLG4 | S422 | ochoa | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}. |
| Q03111 | MLLT1 | S325 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q04726 | TLE3 | S207 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q08945 | SSRP1 | S671 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q12789 | GTF3C1 | S761 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12888 | TP53BP1 | Y522 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12923 | PTPN13 | S1014 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q12929 | EPS8 | Y485 | ochoa|psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q12959 | DLG1 | S575 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q12986 | NFX1 | S154 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13185 | CBX3 | S99 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
| Q13315 | ATM | S1893 | psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13884 | SNTB1 | S236 | ochoa | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
| Q13905 | RAPGEF1 | S375 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q15022 | SUZ12 | S384 | ochoa | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15057 | ACAP2 | S521 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15139 | PRKD1 | S239 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15293 | RCN1 | S80 | ochoa | Reticulocalbin-1 | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. |
| Q15464 | SHB | S314 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q53QZ3 | ARHGAP15 | S221 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q5BKY9 | FAM133B | S198 | ochoa | Protein FAM133B | None |
| Q5SW79 | CEP170 | S126 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SW79 | CEP170 | S1280 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q69YH5 | CDCA2 | S981 | psp | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6AZW8 | ZNF660 | S27 | ochoa | Zinc finger protein 660 | May be involved in transcriptional regulation. |
| Q6GQQ9 | OTUD7B | S471 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6P2E9 | EDC4 | S1154 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6VMQ6 | ATF7IP | S483 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6WKZ4 | RAB11FIP1 | S236 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q7L1W4 | LRRC8D | S250 | ochoa | Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309). {ECO:0000250|UniProtKB:Q8BGR2, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:32415200, ECO:0000269|PubMed:33171122}. |
| Q7Z3J3 | RGPD4 | S1595 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z417 | NUFIP2 | S216 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z4H7 | HAUS6 | S556 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z5K2 | WAPL | S81 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6E9 | RBBP6 | S1648 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86TI0 | TBC1D1 | S575 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86UP2 | KTN1 | S79 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q8N5P1 | ZC3H8 | S86 | ochoa | Zinc finger CCCH domain-containing protein 8 | Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}. |
| Q8N6H7 | ARFGAP2 | S418 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8N806 | UBR7 | S267 | ochoa | Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7) | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. {ECO:0000250}. |
| Q8N8S7 | ENAH | T467 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8NEC7 | GSTCD | S234 | ochoa | Glutathione S-transferase C-terminal domain-containing protein | None |
| Q8NHM5 | KDM2B | S979 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8TEK3 | DOT1L | S1039 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TEQ6 | GEMIN5 | S854 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8WUM0 | NUP133 | S76 | psp | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WUM0 | NUP133 | S501 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WUM9 | SLC20A1 | S269 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q92613 | JADE3 | S780 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92793 | CREBBP | S1076 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92889 | ERCC4 | S524 | ochoa | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. {ECO:0000269|PubMed:10413517, ECO:0000269|PubMed:11790111, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:24027083, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:8797827}. |
| Q96C24 | SYTL4 | S213 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96RT1 | ERBIN | S444 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96SI9 | STRBP | S474 | ochoa | Spermatid perinuclear RNA-binding protein | Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}. |
| Q96ST2 | IWS1 | S84 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S213 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S252 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96ST2 | IWS1 | S304 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q99081 | TCF12 | S544 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99569 | PKP4 | S1157 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99590 | SCAF11 | S1114 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99666 | RGPD5 | S1594 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99708 | RBBP8 | S349 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q9BSQ5 | CCM2 | S185 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BSQ5 | CCM2 | S252 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BTX1 | NDC1 | S504 | ochoa | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
| Q9BUZ4 | TRAF4 | S430 | ochoa | TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) | Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273). {ECO:0000250, ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600, ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:30352854, ECO:0000269|PubMed:31076633, ECO:0000269|PubMed:32268273, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33991522}. |
| Q9BV36 | MLPH | S318 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BWT3 | PAPOLG | S650 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BXF6 | RAB11FIP5 | S498 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BZI7 | UPF3B | S416 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9H2H9 | SLC38A1 | S56 | ochoa | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}. |
| Q9H582 | ZNF644 | S398 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H6X5 | C19orf44 | S118 | ochoa | Uncharacterized protein C19orf44 | None |
| Q9HC77 | CPAP | S768 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NQS7 | INCENP | S218 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NY27 | PPP4R2 | S220 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9NYD6 | HOXC10 | S230 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9NYF8 | BCLAF1 | S198 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9UDT6 | CLIP2 | S211 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UJX6 | ANAPC2 | S736 | ochoa | Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) | Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11739784, PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZQ7, ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UKI8 | TLK1 | S109 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UKJ3 | GPATCH8 | S353 | ochoa | G patch domain-containing protein 8 | None |
| Q9ULI0 | ATAD2B | S83 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULU4 | ZMYND8 | S711 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UNY4 | TTF2 | S251 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPQ0 | LIMCH1 | S235 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9Y3R5 | DOP1B | S654 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y3T9 | NOC2L | S30 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y5B6 | PAXBP1 | S158 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y6Y8 | SEC23IP | S742 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| V9GYH0 | None | S35 | ochoa | Homeobox domain-containing protein | None |
| Q01105 | SET | S168 | Sugiyama | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| P22314 | UBA1 | S824 | Sugiyama | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| Q99613 | EIF3C | S154 | Sugiyama | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q14203 | DCTN1 | S421 | Sugiyama | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q12849 | GRSF1 | S202 | Sugiyama | G-rich sequence factor 1 (GRSF-1) | Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:29967381}. |
| Q6NZY4 | ZCCHC8 | S605 | Sugiyama | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q7RTN6 | STRADA | S49 | Sugiyama | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}. |
| Q16513 | PKN2 | Y624 | Sugiyama | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q8N568 | DCLK2 | S185 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q9Y4K4 | MAP4K5 | S423 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-180746 | Nuclear import of Rev protein | 2.400547e-07 | 6.620 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.043408e-06 | 5.690 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.388820e-06 | 5.622 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.388820e-06 | 5.622 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.222761e-06 | 5.492 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.222761e-06 | 5.492 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.720786e-06 | 5.429 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.943288e-06 | 5.711 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.939946e-07 | 6.226 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.720786e-06 | 5.429 |
| R-HSA-1640170 | Cell Cycle | 1.176903e-06 | 5.929 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.185503e-06 | 5.378 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.905019e-06 | 5.309 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.015709e-06 | 5.221 |
| R-HSA-191859 | snRNP Assembly | 6.015709e-06 | 5.221 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 6.378713e-06 | 5.195 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 7.239837e-06 | 5.140 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 8.192905e-06 | 5.087 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 8.192905e-06 | 5.087 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 9.245188e-06 | 5.034 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 9.245188e-06 | 5.034 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.040433e-05 | 4.983 |
| R-HSA-68886 | M Phase | 1.500120e-05 | 4.824 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.809755e-05 | 4.742 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.008021e-05 | 4.697 |
| R-HSA-447038 | NrCAM interactions | 5.326338e-05 | 4.274 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.581736e-05 | 4.253 |
| R-HSA-68877 | Mitotic Prometaphase | 6.250119e-05 | 4.204 |
| R-HSA-3371556 | Cellular response to heat stress | 7.354200e-05 | 4.133 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.729908e-05 | 4.112 |
| R-HSA-6784531 | tRNA processing in the nucleus | 8.358280e-05 | 4.078 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.209400e-05 | 4.036 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 9.384515e-05 | 4.028 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.593940e-04 | 3.798 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.727831e-04 | 3.762 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.716270e-04 | 3.765 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.088715e-04 | 3.680 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.322648e-04 | 3.634 |
| R-HSA-9620244 | Long-term potentiation | 2.911080e-04 | 3.536 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 3.264935e-04 | 3.486 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 4.048107e-04 | 3.393 |
| R-HSA-162587 | HIV Life Cycle | 4.196727e-04 | 3.377 |
| R-HSA-68875 | Mitotic Prophase | 4.417852e-04 | 3.355 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.374399e-04 | 3.270 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.251466e-04 | 3.280 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 7.983731e-04 | 3.098 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 7.983731e-04 | 3.098 |
| R-HSA-162906 | HIV Infection | 9.295044e-04 | 3.032 |
| R-HSA-70171 | Glycolysis | 9.513036e-04 | 3.022 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.558686e-04 | 3.020 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 9.587430e-04 | 3.018 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.257148e-03 | 2.901 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.233552e-03 | 2.909 |
| R-HSA-211000 | Gene Silencing by RNA | 1.353467e-03 | 2.869 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.424941e-03 | 2.846 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.467699e-03 | 2.833 |
| R-HSA-380287 | Centrosome maturation | 1.584392e-03 | 2.800 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.663718e-03 | 2.779 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.854033e-03 | 2.732 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.915001e-03 | 2.718 |
| R-HSA-70326 | Glucose metabolism | 2.185439e-03 | 2.660 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.468319e-03 | 2.608 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.641168e-03 | 2.578 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.641168e-03 | 2.578 |
| R-HSA-5619102 | SLC transporter disorders | 2.774716e-03 | 2.557 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.091148e-03 | 2.510 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.369475e-03 | 2.472 |
| R-HSA-168255 | Influenza Infection | 4.011885e-03 | 2.397 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.240230e-03 | 2.373 |
| R-HSA-69275 | G2/M Transition | 4.831238e-03 | 2.316 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 5.012803e-03 | 2.300 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.086989e-03 | 2.294 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.430226e-03 | 2.265 |
| R-HSA-399719 | Trafficking of AMPA receptors | 6.321453e-03 | 2.199 |
| R-HSA-9609690 | HCMV Early Events | 6.213051e-03 | 2.207 |
| R-HSA-8953854 | Metabolism of RNA | 5.605454e-03 | 2.251 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 6.611805e-03 | 2.180 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 7.296677e-03 | 2.137 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 7.296677e-03 | 2.137 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 7.296677e-03 | 2.137 |
| R-HSA-74160 | Gene expression (Transcription) | 8.017660e-03 | 2.096 |
| R-HSA-9610379 | HCMV Late Events | 8.708431e-03 | 2.060 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 9.093690e-03 | 2.041 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.010683e-02 | 1.995 |
| R-HSA-68882 | Mitotic Anaphase | 1.004930e-02 | 1.998 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.026713e-02 | 1.989 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.637425e-03 | 2.016 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.041646e-02 | 1.982 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.089082e-02 | 1.963 |
| R-HSA-5693538 | Homology Directed Repair | 1.094669e-02 | 1.961 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.131076e-02 | 1.947 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.196345e-02 | 1.922 |
| R-HSA-72306 | tRNA processing | 1.235022e-02 | 1.908 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.243178e-02 | 1.905 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.268130e-02 | 1.897 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.346508e-02 | 1.871 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.519314e-02 | 1.818 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.519314e-02 | 1.818 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.466761e-02 | 1.834 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.573043e-02 | 1.803 |
| R-HSA-69481 | G2/M Checkpoints | 1.458139e-02 | 1.836 |
| R-HSA-9675135 | Diseases of DNA repair | 1.738621e-02 | 1.760 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.451865e-02 | 1.838 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.627954e-02 | 1.788 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 1.852678e-02 | 1.732 |
| R-HSA-4839726 | Chromatin organization | 1.920607e-02 | 1.717 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.942909e-02 | 1.712 |
| R-HSA-9609646 | HCMV Infection | 1.955219e-02 | 1.709 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 1.979889e-02 | 1.703 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.261517e-02 | 1.646 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.284614e-02 | 1.641 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.383654e-02 | 1.623 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.446589e-02 | 1.611 |
| R-HSA-9834899 | Specification of the neural plate border | 2.446589e-02 | 1.611 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.498399e-02 | 1.602 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.637638e-02 | 1.579 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.637638e-02 | 1.579 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.637638e-02 | 1.579 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.637638e-02 | 1.579 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.637638e-02 | 1.579 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.748745e-02 | 1.561 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.913287e-02 | 1.536 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.944891e-02 | 1.531 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 2.955175e-02 | 1.529 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.901997e-02 | 1.409 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.402911e-02 | 1.468 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.245301e-02 | 1.489 |
| R-HSA-162582 | Signal Transduction | 3.814039e-02 | 1.419 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.920817e-02 | 1.407 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.920817e-02 | 1.407 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.920817e-02 | 1.407 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.920817e-02 | 1.407 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.920817e-02 | 1.407 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.920817e-02 | 1.407 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.920817e-02 | 1.407 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.920817e-02 | 1.407 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.920817e-02 | 1.407 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.920817e-02 | 1.407 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.920817e-02 | 1.407 |
| R-HSA-373760 | L1CAM interactions | 4.238370e-02 | 1.373 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 4.365354e-02 | 1.360 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 4.365354e-02 | 1.360 |
| R-HSA-597592 | Post-translational protein modification | 4.718587e-02 | 1.326 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 4.876910e-02 | 1.312 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 4.876910e-02 | 1.312 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 4.876910e-02 | 1.312 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 4.876910e-02 | 1.312 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 5.823547e-02 | 1.235 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.848027e-02 | 1.314 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 6.402729e-02 | 1.194 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 6.402729e-02 | 1.194 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 6.133147e-02 | 1.212 |
| R-HSA-9930044 | Nuclear RNA decay | 5.867607e-02 | 1.232 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.867607e-02 | 1.232 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 6.402729e-02 | 1.194 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 6.402729e-02 | 1.194 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.987202e-02 | 1.302 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.329086e-02 | 1.273 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 4.876910e-02 | 1.312 |
| R-HSA-390651 | Dopamine receptors | 5.823547e-02 | 1.235 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.908413e-02 | 1.229 |
| R-HSA-5617833 | Cilium Assembly | 5.987254e-02 | 1.223 |
| R-HSA-1538133 | G0 and Early G1 | 5.606215e-02 | 1.251 |
| R-HSA-9008059 | Interleukin-37 signaling | 5.096314e-02 | 1.293 |
| R-HSA-9679506 | SARS-CoV Infections | 6.476346e-02 | 1.189 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.676245e-02 | 1.175 |
| R-HSA-399710 | Activation of AMPA receptors | 6.760821e-02 | 1.170 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 6.760821e-02 | 1.170 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 6.760821e-02 | 1.170 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 6.760821e-02 | 1.170 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 7.519377e-02 | 1.124 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 7.688824e-02 | 1.114 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.480793e-02 | 1.072 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.607648e-02 | 1.065 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 8.607648e-02 | 1.065 |
| R-HSA-69242 | S Phase | 8.624414e-02 | 1.064 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 9.517383e-02 | 1.021 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.130994e-01 | 0.947 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.130994e-01 | 0.947 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.130994e-01 | 0.947 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.219294e-01 | 0.914 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.393281e-01 | 0.856 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.563842e-01 | 0.806 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.731043e-01 | 0.762 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.813405e-01 | 0.742 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.813405e-01 | 0.742 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.055630e-01 | 0.687 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.134778e-01 | 0.671 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 8.993932e-02 | 1.046 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.290730e-01 | 0.640 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.367551e-01 | 0.626 |
| R-HSA-72187 | mRNA 3'-end processing | 1.216178e-01 | 0.915 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 9.691835e-02 | 1.014 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.563842e-01 | 0.806 |
| R-HSA-9664873 | Pexophagy | 1.219294e-01 | 0.914 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.443610e-01 | 0.612 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.451670e-01 | 0.838 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.894951e-01 | 0.722 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.478986e-01 | 0.830 |
| R-HSA-4641265 | Repression of WNT target genes | 1.478986e-01 | 0.830 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.731011e-01 | 0.762 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.975690e-01 | 0.704 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.813405e-01 | 0.742 |
| R-HSA-9664420 | Killing mechanisms | 1.813405e-01 | 0.742 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.975690e-01 | 0.704 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 1.118442e-01 | 0.951 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.112680e-01 | 0.954 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.112680e-01 | 0.954 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.837931e-01 | 0.736 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.909740e-01 | 0.719 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.306720e-01 | 0.884 |
| R-HSA-912446 | Meiotic recombination | 1.183367e-01 | 0.927 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.393281e-01 | 0.856 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.731011e-01 | 0.762 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.176542e-01 | 0.929 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.393281e-01 | 0.856 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.393281e-01 | 0.856 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.478986e-01 | 0.830 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.894951e-01 | 0.722 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.055630e-01 | 0.687 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.443610e-01 | 0.612 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.802180e-01 | 0.744 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.216178e-01 | 0.915 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.176542e-01 | 0.929 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.590174e-01 | 0.799 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.130994e-01 | 0.947 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.478986e-01 | 0.830 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.041812e-01 | 0.982 |
| R-HSA-5358508 | Mismatch Repair | 2.055630e-01 | 0.687 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.219294e-01 | 0.914 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.731043e-01 | 0.762 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.590174e-01 | 0.799 |
| R-HSA-1500620 | Meiosis | 2.383720e-01 | 0.623 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.310151e-01 | 0.883 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.041812e-01 | 0.982 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 1.041812e-01 | 0.982 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.393281e-01 | 0.856 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.894951e-01 | 0.722 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.894951e-01 | 0.722 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.290730e-01 | 0.640 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.854785e-01 | 0.732 |
| R-HSA-8852135 | Protein ubiquitination | 2.018135e-01 | 0.695 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.086345e-01 | 0.964 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.593476e-01 | 0.586 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.054428e-01 | 0.687 |
| R-HSA-73894 | DNA Repair | 1.822035e-01 | 0.739 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.130994e-01 | 0.947 |
| R-HSA-392517 | Rap1 signalling | 2.134778e-01 | 0.671 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.894951e-01 | 0.722 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.055630e-01 | 0.687 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.945786e-01 | 0.711 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.036254e-01 | 0.691 |
| R-HSA-195721 | Signaling by WNT | 2.142661e-01 | 0.669 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.130994e-01 | 0.947 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.563842e-01 | 0.806 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.813405e-01 | 0.742 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.520605e-01 | 0.818 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.814512e-01 | 0.741 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.775107e-01 | 0.751 |
| R-HSA-199991 | Membrane Trafficking | 1.348533e-01 | 0.870 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.695605e-01 | 0.771 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.130994e-01 | 0.947 |
| R-HSA-5682910 | LGI-ADAM interactions | 1.306720e-01 | 0.884 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.563842e-01 | 0.806 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.647859e-01 | 0.783 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.731043e-01 | 0.762 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.813405e-01 | 0.742 |
| R-HSA-1483148 | Synthesis of PG | 1.894951e-01 | 0.722 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.055630e-01 | 0.687 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.593476e-01 | 0.586 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 1.451670e-01 | 0.838 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.486055e-01 | 0.828 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 1.731011e-01 | 0.762 |
| R-HSA-2559583 | Cellular Senescence | 1.398766e-01 | 0.854 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.813405e-01 | 0.742 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 9.605812e-02 | 1.017 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.593476e-01 | 0.586 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.813405e-01 | 0.742 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.894951e-01 | 0.722 |
| R-HSA-170968 | Frs2-mediated activation | 1.563842e-01 | 0.806 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.903253e-01 | 0.721 |
| R-HSA-2262752 | Cellular responses to stress | 2.409999e-01 | 0.618 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.837931e-01 | 0.736 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.981920e-01 | 0.703 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.731043e-01 | 0.762 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.134778e-01 | 0.671 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.873786e-01 | 0.727 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.647859e-01 | 0.783 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.043852e-01 | 0.981 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.486055e-01 | 0.828 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.290730e-01 | 0.640 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.909740e-01 | 0.719 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.290730e-01 | 0.640 |
| R-HSA-169893 | Prolonged ERK activation events | 1.813405e-01 | 0.742 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.909740e-01 | 0.719 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.272085e-01 | 0.895 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.341956e-01 | 0.872 |
| R-HSA-210991 | Basigin interactions | 2.290730e-01 | 0.640 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.834325e-01 | 0.737 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.837931e-01 | 0.736 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.055630e-01 | 0.687 |
| R-HSA-375280 | Amine ligand-binding receptors | 9.605812e-02 | 1.017 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 8.993932e-02 | 1.046 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.353245e-01 | 0.869 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.367551e-01 | 0.626 |
| R-HSA-9824446 | Viral Infection Pathways | 2.589897e-01 | 0.587 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.813405e-01 | 0.742 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.018135e-01 | 0.695 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.531052e-01 | 0.597 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.306720e-01 | 0.884 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.383422e-01 | 0.859 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.593476e-01 | 0.586 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.593476e-01 | 0.586 |
| R-HSA-8939211 | ESR-mediated signaling | 1.166941e-01 | 0.933 |
| R-HSA-9758941 | Gastrulation | 2.343416e-01 | 0.630 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.422685e-01 | 0.616 |
| R-HSA-422475 | Axon guidance | 2.074263e-01 | 0.683 |
| R-HSA-9675108 | Nervous system development | 2.574003e-01 | 0.589 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.660326e-01 | 0.780 |
| R-HSA-913531 | Interferon Signaling | 1.121453e-01 | 0.950 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.457342e-01 | 0.610 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.054428e-01 | 0.687 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.344224e-01 | 0.872 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.494188e-01 | 0.603 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.601266e-01 | 0.585 |
| R-HSA-9839394 | TGFBR3 expression | 2.667298e-01 | 0.574 |
| R-HSA-3214842 | HDMs demethylate histones | 2.667298e-01 | 0.574 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.678608e-01 | 0.572 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.740388e-01 | 0.562 |
| R-HSA-525793 | Myogenesis | 2.740388e-01 | 0.562 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.812754e-01 | 0.551 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.812754e-01 | 0.551 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.812754e-01 | 0.551 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.812754e-01 | 0.551 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.812754e-01 | 0.551 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.884404e-01 | 0.540 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.884404e-01 | 0.540 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.884404e-01 | 0.540 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.899835e-01 | 0.538 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.899835e-01 | 0.538 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.902568e-01 | 0.537 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.955343e-01 | 0.529 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.955343e-01 | 0.529 |
| R-HSA-5688426 | Deubiquitination | 2.963604e-01 | 0.528 |
| R-HSA-3214847 | HATs acetylate histones | 3.010198e-01 | 0.521 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.010198e-01 | 0.521 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.014511e-01 | 0.521 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.014511e-01 | 0.521 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.014511e-01 | 0.521 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.025580e-01 | 0.519 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.025580e-01 | 0.519 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.025580e-01 | 0.519 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.025580e-01 | 0.519 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.025580e-01 | 0.519 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.025580e-01 | 0.519 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.025580e-01 | 0.519 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.025580e-01 | 0.519 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.095120e-01 | 0.509 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.095120e-01 | 0.509 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.095120e-01 | 0.509 |
| R-HSA-186763 | Downstream signal transduction | 3.095120e-01 | 0.509 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.120281e-01 | 0.506 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.120281e-01 | 0.506 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.142816e-01 | 0.503 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.163972e-01 | 0.500 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.172808e-01 | 0.499 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.193474e-01 | 0.496 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.193474e-01 | 0.496 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.232141e-01 | 0.491 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.232141e-01 | 0.491 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.232141e-01 | 0.491 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.299634e-01 | 0.482 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.299634e-01 | 0.482 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.299634e-01 | 0.482 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.299634e-01 | 0.482 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.302914e-01 | 0.481 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.366459e-01 | 0.473 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.366459e-01 | 0.473 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.366459e-01 | 0.473 |
| R-HSA-203615 | eNOS activation | 3.366459e-01 | 0.473 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.366459e-01 | 0.473 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.374405e-01 | 0.472 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.375610e-01 | 0.472 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.412063e-01 | 0.467 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.432621e-01 | 0.464 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.432621e-01 | 0.464 |
| R-HSA-187687 | Signalling to ERKs | 3.432621e-01 | 0.464 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.498128e-01 | 0.456 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.498128e-01 | 0.456 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.498128e-01 | 0.456 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.498128e-01 | 0.456 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.498128e-01 | 0.456 |
| R-HSA-4641258 | Degradation of DVL | 3.562985e-01 | 0.448 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.562985e-01 | 0.448 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.562985e-01 | 0.448 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.592218e-01 | 0.445 |
| R-HSA-8875878 | MET promotes cell motility | 3.627199e-01 | 0.440 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.627199e-01 | 0.440 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.627199e-01 | 0.440 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.640109e-01 | 0.439 |
| R-HSA-69541 | Stabilization of p53 | 3.690776e-01 | 0.433 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.690776e-01 | 0.433 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.690776e-01 | 0.433 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.690776e-01 | 0.433 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.753723e-01 | 0.426 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.753723e-01 | 0.426 |
| R-HSA-167169 | HIV Transcription Elongation | 3.753723e-01 | 0.426 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.753723e-01 | 0.426 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.753723e-01 | 0.426 |
| R-HSA-3371568 | Attenuation phase | 3.753723e-01 | 0.426 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.753723e-01 | 0.426 |
| R-HSA-71240 | Tryptophan catabolism | 3.753723e-01 | 0.426 |
| R-HSA-202433 | Generation of second messenger molecules | 3.753723e-01 | 0.426 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.816046e-01 | 0.418 |
| R-HSA-9607240 | FLT3 Signaling | 3.816046e-01 | 0.418 |
| R-HSA-392499 | Metabolism of proteins | 3.863342e-01 | 0.413 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.877751e-01 | 0.411 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.877751e-01 | 0.411 |
| R-HSA-73886 | Chromosome Maintenance | 3.912120e-01 | 0.408 |
| R-HSA-165159 | MTOR signalling | 3.938844e-01 | 0.405 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.982270e-01 | 0.400 |
| R-HSA-9710421 | Defective pyroptosis | 3.999331e-01 | 0.398 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.999331e-01 | 0.398 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.017206e-01 | 0.396 |
| R-HSA-212436 | Generic Transcription Pathway | 4.054657e-01 | 0.392 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.086793e-01 | 0.389 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.086793e-01 | 0.389 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.086793e-01 | 0.389 |
| R-HSA-69206 | G1/S Transition | 4.086793e-01 | 0.389 |
| R-HSA-1266738 | Developmental Biology | 4.101207e-01 | 0.387 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.118511e-01 | 0.385 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.118511e-01 | 0.385 |
| R-HSA-774815 | Nucleosome assembly | 4.118511e-01 | 0.385 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.118511e-01 | 0.385 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.118511e-01 | 0.385 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.118511e-01 | 0.385 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.124185e-01 | 0.385 |
| R-HSA-114608 | Platelet degranulation | 4.155989e-01 | 0.381 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.177216e-01 | 0.379 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.177216e-01 | 0.379 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.177216e-01 | 0.379 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.177216e-01 | 0.379 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.177216e-01 | 0.379 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.177216e-01 | 0.379 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.190436e-01 | 0.378 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.235339e-01 | 0.373 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.235339e-01 | 0.373 |
| R-HSA-437239 | Recycling pathway of L1 | 4.235339e-01 | 0.373 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.235339e-01 | 0.373 |
| R-HSA-418990 | Adherens junctions interactions | 4.256802e-01 | 0.371 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.292885e-01 | 0.367 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.292885e-01 | 0.367 |
| R-HSA-1474165 | Reproduction | 4.293161e-01 | 0.367 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.349860e-01 | 0.362 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.349860e-01 | 0.362 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.394930e-01 | 0.357 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.462120e-01 | 0.350 |
| R-HSA-2514856 | The phototransduction cascade | 4.462120e-01 | 0.350 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.466809e-01 | 0.350 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.517416e-01 | 0.345 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.517416e-01 | 0.345 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.517416e-01 | 0.345 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.572163e-01 | 0.340 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.572163e-01 | 0.340 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.572163e-01 | 0.340 |
| R-HSA-72649 | Translation initiation complex formation | 4.626367e-01 | 0.335 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.626367e-01 | 0.335 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.626367e-01 | 0.335 |
| R-HSA-6807070 | PTEN Regulation | 4.628494e-01 | 0.335 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.628494e-01 | 0.335 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.680033e-01 | 0.330 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.680033e-01 | 0.330 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.680033e-01 | 0.330 |
| R-HSA-449147 | Signaling by Interleukins | 4.684551e-01 | 0.329 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.733166e-01 | 0.325 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.733166e-01 | 0.325 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.733166e-01 | 0.325 |
| R-HSA-75893 | TNF signaling | 4.733166e-01 | 0.325 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.733166e-01 | 0.325 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.791826e-01 | 0.319 |
| R-HSA-157118 | Signaling by NOTCH | 4.826736e-01 | 0.316 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.837856e-01 | 0.315 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.837856e-01 | 0.315 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.888372e-01 | 0.311 |
| R-HSA-180786 | Extension of Telomeres | 4.889422e-01 | 0.311 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.889422e-01 | 0.311 |
| R-HSA-186712 | Regulation of beta-cell development | 4.889422e-01 | 0.311 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.940477e-01 | 0.306 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.940477e-01 | 0.306 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.940477e-01 | 0.306 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.940477e-01 | 0.306 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.940477e-01 | 0.306 |
| R-HSA-983189 | Kinesins | 4.940477e-01 | 0.306 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.940477e-01 | 0.306 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.940477e-01 | 0.306 |
| R-HSA-166520 | Signaling by NTRKs | 4.952116e-01 | 0.305 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.991025e-01 | 0.302 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.041070e-01 | 0.297 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.041070e-01 | 0.297 |
| R-HSA-9707616 | Heme signaling | 5.041070e-01 | 0.297 |
| R-HSA-186797 | Signaling by PDGF | 5.041070e-01 | 0.297 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.041070e-01 | 0.297 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.078094e-01 | 0.294 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.090619e-01 | 0.293 |
| R-HSA-421270 | Cell-cell junction organization | 5.101701e-01 | 0.292 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.140318e-01 | 0.289 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.188246e-01 | 0.285 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.188246e-01 | 0.285 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.331079e-01 | 0.273 |
| R-HSA-167172 | Transcription of the HIV genome | 5.331079e-01 | 0.273 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.331079e-01 | 0.273 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.331079e-01 | 0.273 |
| R-HSA-112316 | Neuronal System | 5.422947e-01 | 0.266 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.423953e-01 | 0.266 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.423953e-01 | 0.266 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.423953e-01 | 0.266 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.469699e-01 | 0.262 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.469699e-01 | 0.262 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.469699e-01 | 0.262 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.514990e-01 | 0.258 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.559832e-01 | 0.255 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.604227e-01 | 0.251 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.604227e-01 | 0.251 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.648182e-01 | 0.248 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.648182e-01 | 0.248 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.650876e-01 | 0.248 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.691700e-01 | 0.245 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.705207e-01 | 0.244 |
| R-HSA-446728 | Cell junction organization | 5.742535e-01 | 0.241 |
| R-HSA-4086400 | PCP/CE pathway | 5.777442e-01 | 0.238 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.777442e-01 | 0.238 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.789975e-01 | 0.237 |
| R-HSA-9659379 | Sensory processing of sound | 5.819675e-01 | 0.235 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.819675e-01 | 0.235 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.832997e-01 | 0.234 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.861489e-01 | 0.232 |
| R-HSA-9833482 | PKR-mediated signaling | 5.861489e-01 | 0.232 |
| R-HSA-6806834 | Signaling by MET | 5.861489e-01 | 0.232 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.902886e-01 | 0.229 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.943872e-01 | 0.226 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.984451e-01 | 0.223 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.988376e-01 | 0.223 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.024626e-01 | 0.220 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.024626e-01 | 0.220 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.064402e-01 | 0.217 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.111608e-01 | 0.214 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.139962e-01 | 0.212 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.142770e-01 | 0.212 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.143165e-01 | 0.212 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.181371e-01 | 0.209 |
| R-HSA-9663891 | Selective autophagy | 6.219588e-01 | 0.206 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.298425e-01 | 0.201 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.331973e-01 | 0.198 |
| R-HSA-391251 | Protein folding | 6.405045e-01 | 0.193 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.441036e-01 | 0.191 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.448817e-01 | 0.191 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.490589e-01 | 0.188 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.511949e-01 | 0.186 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.546877e-01 | 0.184 |
| R-HSA-1500931 | Cell-Cell communication | 6.551691e-01 | 0.184 |
| R-HSA-72172 | mRNA Splicing | 6.570450e-01 | 0.182 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.581457e-01 | 0.182 |
| R-HSA-157579 | Telomere Maintenance | 6.615693e-01 | 0.179 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.615693e-01 | 0.179 |
| R-HSA-6805567 | Keratinization | 6.618169e-01 | 0.179 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.649589e-01 | 0.177 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.649589e-01 | 0.177 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.649589e-01 | 0.177 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.716371e-01 | 0.173 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.749264e-01 | 0.171 |
| R-HSA-1483255 | PI Metabolism | 6.781830e-01 | 0.169 |
| R-HSA-192823 | Viral mRNA Translation | 6.814071e-01 | 0.167 |
| R-HSA-9833110 | RSV-host interactions | 6.877594e-01 | 0.163 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.908882e-01 | 0.161 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.908882e-01 | 0.161 |
| R-HSA-69239 | Synthesis of DNA | 6.970527e-01 | 0.157 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.000889e-01 | 0.155 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.000889e-01 | 0.155 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.000889e-01 | 0.155 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.030949e-01 | 0.153 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.030949e-01 | 0.153 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.060709e-01 | 0.151 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.060709e-01 | 0.151 |
| R-HSA-202403 | TCR signaling | 7.060709e-01 | 0.151 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.119344e-01 | 0.148 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.119344e-01 | 0.148 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.126375e-01 | 0.147 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.148224e-01 | 0.146 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.148224e-01 | 0.146 |
| R-HSA-72312 | rRNA processing | 7.191147e-01 | 0.143 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.233148e-01 | 0.141 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.233148e-01 | 0.141 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.260894e-01 | 0.139 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.288363e-01 | 0.137 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.288363e-01 | 0.137 |
| R-HSA-1643685 | Disease | 7.298912e-01 | 0.137 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.315559e-01 | 0.136 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.369139e-01 | 0.133 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.369139e-01 | 0.133 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.421657e-01 | 0.129 |
| R-HSA-5663205 | Infectious disease | 7.421975e-01 | 0.129 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.447524e-01 | 0.128 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.447524e-01 | 0.128 |
| R-HSA-1280218 | Adaptive Immune System | 7.460650e-01 | 0.127 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.473133e-01 | 0.126 |
| R-HSA-977606 | Regulation of Complement cascade | 7.523587e-01 | 0.124 |
| R-HSA-194138 | Signaling by VEGF | 7.548437e-01 | 0.122 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.645854e-01 | 0.117 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.713045e-01 | 0.113 |
| R-HSA-9843745 | Adipogenesis | 7.715586e-01 | 0.113 |
| R-HSA-9909396 | Circadian clock | 7.738521e-01 | 0.111 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.849809e-01 | 0.105 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 7.867564e-01 | 0.104 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.871405e-01 | 0.104 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.892785e-01 | 0.103 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.908188e-01 | 0.102 |
| R-HSA-1632852 | Macroautophagy | 7.955653e-01 | 0.099 |
| R-HSA-166658 | Complement cascade | 8.056317e-01 | 0.094 |
| R-HSA-2187338 | Visual phototransduction | 8.095190e-01 | 0.092 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.114335e-01 | 0.091 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.152054e-01 | 0.089 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.170631e-01 | 0.088 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.189023e-01 | 0.087 |
| R-HSA-109582 | Hemostasis | 8.201587e-01 | 0.086 |
| R-HSA-168256 | Immune System | 8.206787e-01 | 0.086 |
| R-HSA-69306 | DNA Replication | 8.207231e-01 | 0.086 |
| R-HSA-73887 | Death Receptor Signaling | 8.225257e-01 | 0.085 |
| R-HSA-1989781 | PPARA activates gene expression | 8.243103e-01 | 0.084 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.249402e-01 | 0.084 |
| R-HSA-1483257 | Phospholipid metabolism | 8.249402e-01 | 0.084 |
| R-HSA-9612973 | Autophagy | 8.260771e-01 | 0.083 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.278262e-01 | 0.082 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.329693e-01 | 0.079 |
| R-HSA-109581 | Apoptosis | 8.363129e-01 | 0.078 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.505547e-01 | 0.070 |
| R-HSA-418555 | G alpha (s) signalling events | 8.520590e-01 | 0.070 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.520590e-01 | 0.070 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.579274e-01 | 0.067 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.728994e-01 | 0.059 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.790672e-01 | 0.056 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.791759e-01 | 0.056 |
| R-HSA-428157 | Sphingolipid metabolism | 8.908196e-01 | 0.050 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.930109e-01 | 0.049 |
| R-HSA-5357801 | Programmed Cell Death | 8.962162e-01 | 0.048 |
| R-HSA-397014 | Muscle contraction | 9.033288e-01 | 0.044 |
| R-HSA-8951664 | Neddylation | 9.117661e-01 | 0.040 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.249984e-01 | 0.034 |
| R-HSA-418594 | G alpha (i) signalling events | 9.294499e-01 | 0.032 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.452799e-01 | 0.024 |
| R-HSA-500792 | GPCR ligand binding | 9.455401e-01 | 0.024 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.520656e-01 | 0.021 |
| R-HSA-9658195 | Leishmania infection | 9.520656e-01 | 0.021 |
| R-HSA-6798695 | Neutrophil degranulation | 9.536829e-01 | 0.021 |
| R-HSA-8957322 | Metabolism of steroids | 9.690885e-01 | 0.014 |
| R-HSA-1474244 | Extracellular matrix organization | 9.712224e-01 | 0.013 |
| R-HSA-388396 | GPCR downstream signalling | 9.872850e-01 | 0.006 |
| R-HSA-72766 | Translation | 9.895716e-01 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 9.913750e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.936177e-01 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.985249e-01 | 0.001 |
| R-HSA-168249 | Innate Immune System | 9.995120e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.998800e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999699e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GRK1 |
0.771 | 0.296 | -2 | 0.741 |
COT |
0.766 | 0.197 | 2 | 0.846 |
KIS |
0.761 | 0.157 | 1 | 0.591 |
BMPR1B |
0.759 | 0.254 | 1 | 0.801 |
MOS |
0.759 | 0.285 | 1 | 0.850 |
GRK7 |
0.758 | 0.262 | 1 | 0.697 |
CDC7 |
0.750 | 0.113 | 1 | 0.845 |
GRK4 |
0.748 | 0.211 | -2 | 0.736 |
DSTYK |
0.747 | 0.170 | 2 | 0.839 |
CLK3 |
0.745 | 0.081 | 1 | 0.764 |
BMPR1A |
0.745 | 0.222 | 1 | 0.802 |
CK1D |
0.744 | 0.220 | -3 | 0.528 |
GRK5 |
0.744 | 0.141 | -3 | 0.762 |
IKKB |
0.743 | 0.073 | -2 | 0.553 |
CK1E |
0.743 | 0.188 | -3 | 0.566 |
GRK6 |
0.741 | 0.167 | 1 | 0.791 |
IKKA |
0.741 | 0.089 | -2 | 0.567 |
CK2A2 |
0.739 | 0.234 | 1 | 0.729 |
TGFBR1 |
0.738 | 0.144 | -2 | 0.708 |
ALK2 |
0.738 | 0.197 | -2 | 0.721 |
NEK6 |
0.738 | 0.073 | -2 | 0.662 |
PRPK |
0.738 | -0.016 | -1 | 0.578 |
ACVR2B |
0.737 | 0.152 | -2 | 0.693 |
ACVR2A |
0.737 | 0.137 | -2 | 0.682 |
GCN2 |
0.737 | -0.011 | 2 | 0.783 |
TGFBR2 |
0.736 | 0.023 | -2 | 0.696 |
MLK1 |
0.736 | 0.077 | 2 | 0.808 |
CAMK2G |
0.735 | 0.041 | 2 | 0.772 |
BMPR2 |
0.735 | 0.054 | -2 | 0.683 |
FAM20C |
0.733 | 0.078 | 2 | 0.550 |
GRK3 |
0.732 | 0.153 | -2 | 0.635 |
RAF1 |
0.731 | -0.008 | 1 | 0.773 |
MLK3 |
0.731 | 0.079 | 2 | 0.762 |
ALK4 |
0.731 | 0.101 | -2 | 0.703 |
CK1A2 |
0.731 | 0.171 | -3 | 0.517 |
TBK1 |
0.730 | -0.039 | 1 | 0.663 |
IKKE |
0.730 | -0.018 | 1 | 0.668 |
PIM3 |
0.730 | -0.023 | -3 | 0.676 |
NEK7 |
0.730 | 0.019 | -3 | 0.706 |
CHAK2 |
0.729 | 0.005 | -1 | 0.517 |
MTOR |
0.729 | -0.048 | 1 | 0.685 |
GRK2 |
0.729 | 0.111 | -2 | 0.632 |
CK1G1 |
0.728 | 0.138 | -3 | 0.599 |
TTBK2 |
0.728 | 0.064 | 2 | 0.713 |
NDR2 |
0.726 | -0.051 | -3 | 0.680 |
PDHK4 |
0.725 | -0.177 | 1 | 0.771 |
ULK2 |
0.724 | -0.104 | 2 | 0.790 |
CK2A1 |
0.724 | 0.187 | 1 | 0.708 |
MLK4 |
0.724 | 0.055 | 2 | 0.736 |
CK1A |
0.723 | 0.211 | -3 | 0.468 |
PLK1 |
0.723 | 0.044 | -2 | 0.645 |
NLK |
0.723 | -0.041 | 1 | 0.723 |
ERK5 |
0.721 | -0.031 | 1 | 0.685 |
ATR |
0.720 | -0.053 | 1 | 0.688 |
CAMK1B |
0.720 | -0.079 | -3 | 0.673 |
ATM |
0.720 | 0.018 | 1 | 0.630 |
ULK1 |
0.719 | -0.074 | -3 | 0.679 |
CDKL1 |
0.718 | -0.059 | -3 | 0.626 |
PDHK1 |
0.718 | -0.186 | 1 | 0.764 |
LATS1 |
0.718 | 0.001 | -3 | 0.723 |
DLK |
0.718 | -0.013 | 1 | 0.755 |
PKN3 |
0.718 | -0.054 | -3 | 0.636 |
CDK1 |
0.717 | 0.043 | 1 | 0.526 |
TLK2 |
0.717 | 0.032 | 1 | 0.688 |
MST4 |
0.717 | -0.046 | 2 | 0.850 |
RIPK3 |
0.716 | -0.064 | 3 | 0.700 |
TLK1 |
0.716 | 0.127 | -2 | 0.724 |
CAMK2B |
0.716 | 0.012 | 2 | 0.726 |
NIK |
0.716 | -0.112 | -3 | 0.704 |
ANKRD3 |
0.715 | -0.034 | 1 | 0.762 |
SKMLCK |
0.714 | -0.056 | -2 | 0.612 |
YSK4 |
0.714 | -0.004 | 1 | 0.700 |
BCKDK |
0.714 | -0.125 | -1 | 0.498 |
SRPK1 |
0.714 | -0.036 | -3 | 0.577 |
PLK3 |
0.713 | 0.029 | 2 | 0.700 |
PIM1 |
0.713 | -0.045 | -3 | 0.605 |
PKCD |
0.713 | -0.060 | 2 | 0.813 |
PKN2 |
0.713 | -0.051 | -3 | 0.635 |
LATS2 |
0.713 | -0.074 | -5 | 0.721 |
MLK2 |
0.712 | -0.082 | 2 | 0.817 |
RSK2 |
0.712 | -0.070 | -3 | 0.584 |
HIPK4 |
0.712 | -0.046 | 1 | 0.713 |
NEK9 |
0.712 | -0.107 | 2 | 0.840 |
MEKK3 |
0.712 | 0.116 | 1 | 0.716 |
HUNK |
0.711 | -0.062 | 2 | 0.762 |
CDK8 |
0.711 | -0.030 | 1 | 0.551 |
CDKL5 |
0.711 | -0.061 | -3 | 0.610 |
IRE2 |
0.711 | -0.017 | 2 | 0.786 |
NDR1 |
0.710 | -0.108 | -3 | 0.655 |
PKR |
0.710 | -0.022 | 1 | 0.778 |
CAMLCK |
0.710 | -0.104 | -2 | 0.585 |
IRE1 |
0.709 | -0.066 | 1 | 0.730 |
NUAK2 |
0.709 | -0.090 | -3 | 0.642 |
WNK1 |
0.709 | -0.124 | -2 | 0.605 |
SRPK3 |
0.709 | -0.019 | -3 | 0.557 |
PRP4 |
0.709 | 0.071 | -3 | 0.705 |
PERK |
0.708 | -0.019 | -2 | 0.694 |
CAMK2A |
0.707 | -0.024 | 2 | 0.737 |
PRKD1 |
0.707 | -0.106 | -3 | 0.613 |
PKACG |
0.707 | -0.083 | -2 | 0.502 |
AURC |
0.706 | -0.059 | -2 | 0.433 |
CAMK2D |
0.706 | -0.114 | -3 | 0.635 |
AMPKA1 |
0.706 | -0.109 | -3 | 0.653 |
MASTL |
0.706 | -0.187 | -2 | 0.601 |
SRPK2 |
0.706 | -0.043 | -3 | 0.498 |
ICK |
0.705 | -0.084 | -3 | 0.659 |
MAPKAPK2 |
0.705 | -0.058 | -3 | 0.536 |
JNK3 |
0.705 | 0.011 | 1 | 0.551 |
DAPK2 |
0.705 | -0.133 | -3 | 0.682 |
BRAF |
0.705 | 0.012 | -4 | 0.379 |
GSK3A |
0.705 | 0.064 | 4 | 0.493 |
TSSK2 |
0.704 | -0.081 | -5 | 0.789 |
PRKD2 |
0.704 | -0.091 | -3 | 0.556 |
MEK1 |
0.704 | -0.086 | 2 | 0.804 |
PKCB |
0.704 | -0.039 | 2 | 0.762 |
WNK3 |
0.704 | -0.187 | 1 | 0.727 |
PLK2 |
0.703 | 0.073 | -3 | 0.720 |
MEKK2 |
0.703 | 0.038 | 2 | 0.805 |
P70S6KB |
0.703 | -0.093 | -3 | 0.597 |
P90RSK |
0.703 | -0.109 | -3 | 0.590 |
CDK19 |
0.702 | -0.043 | 1 | 0.509 |
CK1G3 |
0.702 | 0.199 | -3 | 0.430 |
AURA |
0.702 | -0.027 | -2 | 0.422 |
PKCG |
0.702 | -0.056 | 2 | 0.755 |
HRI |
0.701 | -0.072 | -2 | 0.667 |
CDK5 |
0.701 | -0.007 | 1 | 0.569 |
MARK4 |
0.701 | -0.127 | 4 | 0.776 |
ZAK |
0.701 | -0.024 | 1 | 0.714 |
RSK3 |
0.701 | -0.104 | -3 | 0.568 |
RSK4 |
0.700 | -0.054 | -3 | 0.569 |
CHAK1 |
0.700 | -0.089 | 2 | 0.768 |
PKCA |
0.700 | -0.056 | 2 | 0.758 |
PRKX |
0.700 | -0.040 | -3 | 0.492 |
DYRK2 |
0.700 | -0.036 | 1 | 0.607 |
RIPK1 |
0.700 | -0.153 | 1 | 0.745 |
JNK2 |
0.700 | -0.001 | 1 | 0.513 |
MAPKAPK3 |
0.700 | -0.126 | -3 | 0.560 |
TAO3 |
0.699 | 0.004 | 1 | 0.711 |
P38G |
0.698 | 0.001 | 1 | 0.441 |
PAK1 |
0.698 | -0.091 | -2 | 0.519 |
VRK2 |
0.698 | -0.192 | 1 | 0.781 |
HIPK2 |
0.698 | -0.009 | 1 | 0.526 |
ERK1 |
0.697 | -0.016 | 1 | 0.511 |
MEKK1 |
0.697 | -0.054 | 1 | 0.718 |
P38B |
0.697 | -0.010 | 1 | 0.524 |
CK1G2 |
0.697 | 0.214 | -3 | 0.515 |
PKACB |
0.697 | -0.064 | -2 | 0.443 |
CDK3 |
0.697 | 0.024 | 1 | 0.460 |
PASK |
0.697 | 0.011 | -3 | 0.697 |
CDK2 |
0.697 | -0.009 | 1 | 0.595 |
TTBK1 |
0.696 | -0.034 | 2 | 0.629 |
AMPKA2 |
0.696 | -0.124 | -3 | 0.616 |
PKCH |
0.696 | -0.071 | 2 | 0.745 |
CLK4 |
0.696 | -0.062 | -3 | 0.573 |
PKCZ |
0.696 | -0.088 | 2 | 0.794 |
CAMK4 |
0.695 | -0.133 | -3 | 0.613 |
TSSK1 |
0.695 | -0.126 | -3 | 0.677 |
CLK2 |
0.695 | -0.016 | -3 | 0.571 |
MST3 |
0.695 | -0.007 | 2 | 0.817 |
PHKG1 |
0.695 | -0.109 | -3 | 0.630 |
NEK2 |
0.694 | -0.124 | 2 | 0.817 |
EEF2K |
0.694 | 0.057 | 3 | 0.824 |
MEK5 |
0.694 | -0.093 | 2 | 0.800 |
CDK7 |
0.694 | -0.072 | 1 | 0.561 |
CDK18 |
0.693 | -0.034 | 1 | 0.487 |
PINK1 |
0.693 | -0.068 | 1 | 0.731 |
P38A |
0.693 | -0.037 | 1 | 0.585 |
CDK13 |
0.693 | -0.057 | 1 | 0.538 |
GSK3B |
0.693 | 0.005 | 4 | 0.482 |
ERK2 |
0.693 | -0.032 | 1 | 0.562 |
AURB |
0.692 | -0.085 | -2 | 0.426 |
HIPK1 |
0.692 | -0.037 | 1 | 0.623 |
MSK2 |
0.692 | -0.107 | -3 | 0.555 |
PKG2 |
0.692 | -0.089 | -2 | 0.436 |
ALPHAK3 |
0.692 | 0.163 | -1 | 0.583 |
NEK8 |
0.691 | -0.009 | 2 | 0.809 |
MST2 |
0.691 | 0.021 | 1 | 0.715 |
SMG1 |
0.691 | -0.113 | 1 | 0.623 |
MNK2 |
0.691 | -0.130 | -2 | 0.511 |
PLK4 |
0.691 | -0.096 | 2 | 0.602 |
PAK3 |
0.691 | -0.140 | -2 | 0.508 |
PAK2 |
0.690 | -0.109 | -2 | 0.506 |
PRKD3 |
0.690 | -0.106 | -3 | 0.515 |
NUAK1 |
0.690 | -0.131 | -3 | 0.584 |
CDK17 |
0.690 | -0.029 | 1 | 0.441 |
MPSK1 |
0.690 | -0.030 | 1 | 0.674 |
DNAPK |
0.690 | -0.065 | 1 | 0.539 |
NEK5 |
0.690 | -0.087 | 1 | 0.721 |
DRAK1 |
0.690 | -0.073 | 1 | 0.679 |
CLK1 |
0.689 | -0.074 | -3 | 0.530 |
MNK1 |
0.689 | -0.119 | -2 | 0.527 |
NIM1 |
0.689 | -0.176 | 3 | 0.736 |
P38D |
0.689 | 0.003 | 1 | 0.434 |
MYLK4 |
0.688 | -0.098 | -2 | 0.529 |
SGK3 |
0.687 | -0.092 | -3 | 0.551 |
GAK |
0.687 | 0.017 | 1 | 0.716 |
CAMKK1 |
0.687 | -0.061 | -2 | 0.532 |
MSK1 |
0.687 | -0.091 | -3 | 0.551 |
TAK1 |
0.686 | 0.029 | 1 | 0.735 |
MELK |
0.686 | -0.165 | -3 | 0.586 |
JNK1 |
0.686 | 0.006 | 1 | 0.503 |
AKT2 |
0.685 | -0.077 | -3 | 0.486 |
TTK |
0.685 | 0.085 | -2 | 0.695 |
GCK |
0.685 | -0.012 | 1 | 0.707 |
CDK12 |
0.684 | -0.059 | 1 | 0.515 |
QIK |
0.684 | -0.178 | -3 | 0.624 |
OSR1 |
0.684 | 0.072 | 2 | 0.796 |
PIM2 |
0.684 | -0.088 | -3 | 0.539 |
CAMK1G |
0.683 | -0.097 | -3 | 0.552 |
NEK11 |
0.683 | -0.059 | 1 | 0.709 |
QSK |
0.683 | -0.131 | 4 | 0.749 |
PAK6 |
0.683 | -0.110 | -2 | 0.423 |
TAO2 |
0.683 | -0.084 | 2 | 0.850 |
TNIK |
0.683 | -0.021 | 3 | 0.847 |
CDK16 |
0.682 | -0.029 | 1 | 0.455 |
DYRK1A |
0.682 | -0.069 | 1 | 0.640 |
IRAK4 |
0.682 | -0.150 | 1 | 0.738 |
MINK |
0.681 | -0.042 | 1 | 0.712 |
MAPKAPK5 |
0.681 | -0.149 | -3 | 0.509 |
CHK1 |
0.681 | -0.162 | -3 | 0.629 |
MST1 |
0.680 | -0.020 | 1 | 0.706 |
CAMKK2 |
0.680 | -0.099 | -2 | 0.516 |
BRSK1 |
0.680 | -0.128 | -3 | 0.579 |
PKACA |
0.680 | -0.081 | -2 | 0.400 |
PKCT |
0.679 | -0.109 | 2 | 0.760 |
SIK |
0.679 | -0.136 | -3 | 0.548 |
DYRK1B |
0.679 | -0.054 | 1 | 0.555 |
ERK7 |
0.679 | -0.016 | 2 | 0.567 |
HGK |
0.678 | -0.074 | 3 | 0.837 |
WNK4 |
0.678 | -0.177 | -2 | 0.586 |
DCAMKL1 |
0.678 | -0.140 | -3 | 0.575 |
CDK14 |
0.678 | -0.057 | 1 | 0.529 |
MARK3 |
0.677 | -0.117 | 4 | 0.709 |
DYRK4 |
0.677 | -0.041 | 1 | 0.531 |
HIPK3 |
0.677 | -0.082 | 1 | 0.620 |
PDK1 |
0.677 | -0.099 | 1 | 0.736 |
MARK2 |
0.677 | -0.122 | 4 | 0.665 |
PDHK1_TYR |
0.676 | 0.253 | -1 | 0.654 |
AKT1 |
0.676 | -0.084 | -3 | 0.499 |
SSTK |
0.676 | -0.116 | 4 | 0.742 |
SMMLCK |
0.676 | -0.127 | -3 | 0.615 |
CDK9 |
0.675 | -0.091 | 1 | 0.545 |
PDHK3_TYR |
0.675 | 0.061 | 4 | 0.873 |
SLK |
0.675 | -0.062 | -2 | 0.516 |
SNRK |
0.675 | -0.186 | 2 | 0.642 |
PKCE |
0.675 | -0.065 | 2 | 0.746 |
PKCI |
0.674 | -0.106 | 2 | 0.770 |
HPK1 |
0.673 | -0.053 | 1 | 0.704 |
LKB1 |
0.673 | -0.115 | -3 | 0.680 |
DYRK3 |
0.673 | -0.074 | 1 | 0.634 |
PDHK4_TYR |
0.673 | 0.125 | 2 | 0.807 |
IRAK1 |
0.673 | -0.180 | -1 | 0.456 |
CDK10 |
0.672 | -0.052 | 1 | 0.516 |
MAP2K6_TYR |
0.672 | 0.145 | -1 | 0.618 |
BRSK2 |
0.672 | -0.182 | -3 | 0.599 |
SYK |
0.672 | 0.238 | -1 | 0.631 |
BMPR2_TYR |
0.671 | 0.086 | -1 | 0.609 |
MARK1 |
0.671 | -0.143 | 4 | 0.729 |
DCAMKL2 |
0.671 | -0.134 | -3 | 0.593 |
VRK1 |
0.671 | -0.125 | 2 | 0.834 |
LRRK2 |
0.671 | -0.143 | 2 | 0.825 |
P70S6K |
0.671 | -0.118 | -3 | 0.493 |
MAP3K15 |
0.670 | -0.122 | 1 | 0.687 |
DAPK3 |
0.670 | -0.091 | -3 | 0.607 |
NEK4 |
0.670 | -0.158 | 1 | 0.702 |
MAP2K4_TYR |
0.669 | 0.092 | -1 | 0.603 |
BUB1 |
0.669 | -0.044 | -5 | 0.760 |
KHS2 |
0.669 | -0.033 | 1 | 0.705 |
LOK |
0.668 | -0.123 | -2 | 0.523 |
KHS1 |
0.667 | -0.072 | 1 | 0.701 |
STK33 |
0.667 | -0.095 | 2 | 0.593 |
PAK5 |
0.667 | -0.119 | -2 | 0.396 |
AKT3 |
0.667 | -0.075 | -3 | 0.431 |
CAMK1D |
0.667 | -0.111 | -3 | 0.469 |
MAK |
0.666 | -0.047 | -2 | 0.500 |
PAK4 |
0.666 | -0.105 | -2 | 0.408 |
HASPIN |
0.666 | -0.036 | -1 | 0.378 |
DAPK1 |
0.666 | -0.079 | -3 | 0.588 |
NEK1 |
0.665 | -0.159 | 1 | 0.719 |
CDK6 |
0.665 | -0.046 | 1 | 0.507 |
SGK1 |
0.665 | -0.072 | -3 | 0.419 |
PHKG2 |
0.665 | -0.168 | -3 | 0.573 |
YSK1 |
0.665 | -0.095 | 2 | 0.819 |
TESK1_TYR |
0.664 | -0.039 | 3 | 0.855 |
TXK |
0.664 | 0.082 | 1 | 0.771 |
MEKK6 |
0.663 | -0.177 | 1 | 0.694 |
ROCK2 |
0.663 | -0.095 | -3 | 0.585 |
RIPK2 |
0.662 | -0.158 | 1 | 0.673 |
EPHA6 |
0.661 | 0.044 | -1 | 0.626 |
YANK3 |
0.660 | -0.010 | 2 | 0.377 |
PKN1 |
0.660 | -0.108 | -3 | 0.499 |
MYO3A |
0.660 | -0.030 | 1 | 0.723 |
MAP2K7_TYR |
0.659 | -0.113 | 2 | 0.810 |
MRCKA |
0.659 | -0.112 | -3 | 0.551 |
MEK2 |
0.659 | -0.205 | 2 | 0.795 |
PINK1_TYR |
0.659 | -0.049 | 1 | 0.763 |
FGR |
0.659 | 0.093 | 1 | 0.722 |
FLT1 |
0.658 | 0.140 | -1 | 0.658 |
MRCKB |
0.658 | -0.109 | -3 | 0.522 |
MOK |
0.657 | -0.080 | 1 | 0.634 |
CDK4 |
0.657 | -0.068 | 1 | 0.500 |
EPHB4 |
0.657 | 0.020 | -1 | 0.605 |
INSRR |
0.656 | 0.064 | 3 | 0.698 |
PKMYT1_TYR |
0.656 | -0.117 | 3 | 0.818 |
ABL2 |
0.656 | 0.031 | -1 | 0.585 |
MYO3B |
0.655 | -0.066 | 2 | 0.833 |
LCK |
0.655 | 0.058 | -1 | 0.582 |
BLK |
0.655 | 0.097 | -1 | 0.605 |
FER |
0.655 | 0.036 | 1 | 0.786 |
CHK2 |
0.654 | -0.106 | -3 | 0.418 |
EPHA4 |
0.653 | 0.048 | 2 | 0.688 |
STLK3 |
0.653 | -0.047 | 1 | 0.676 |
FYN |
0.653 | 0.080 | -1 | 0.558 |
CSF1R |
0.652 | -0.015 | 3 | 0.744 |
CAMK1A |
0.652 | -0.114 | -3 | 0.436 |
PBK |
0.652 | -0.118 | 1 | 0.621 |
ASK1 |
0.651 | -0.118 | 1 | 0.684 |
RET |
0.651 | -0.073 | 1 | 0.719 |
JAK3 |
0.651 | 0.022 | 1 | 0.703 |
HCK |
0.650 | -0.000 | -1 | 0.573 |
KIT |
0.650 | 0.017 | 3 | 0.741 |
EPHB2 |
0.650 | 0.044 | -1 | 0.604 |
ABL1 |
0.649 | -0.001 | -1 | 0.566 |
YES1 |
0.649 | -0.014 | -1 | 0.560 |
JAK2 |
0.649 | -0.068 | 1 | 0.717 |
ROS1 |
0.649 | -0.066 | 3 | 0.721 |
DMPK1 |
0.649 | -0.102 | -3 | 0.556 |
MET |
0.649 | 0.052 | 3 | 0.722 |
TYK2 |
0.649 | -0.126 | 1 | 0.719 |
EGFR |
0.649 | 0.073 | 1 | 0.603 |
SRMS |
0.649 | -0.009 | 1 | 0.789 |
NEK3 |
0.649 | -0.204 | 1 | 0.677 |
LIMK2_TYR |
0.648 | -0.156 | -3 | 0.719 |
TAO1 |
0.648 | -0.124 | 1 | 0.654 |
ROCK1 |
0.648 | -0.105 | -3 | 0.540 |
EPHB1 |
0.647 | -0.014 | 1 | 0.777 |
LIMK1_TYR |
0.646 | -0.169 | 2 | 0.841 |
PKG1 |
0.646 | -0.125 | -2 | 0.366 |
MST1R |
0.646 | -0.113 | 3 | 0.755 |
TYRO3 |
0.645 | -0.126 | 3 | 0.753 |
EPHB3 |
0.645 | -0.005 | -1 | 0.602 |
PTK2 |
0.644 | 0.067 | -1 | 0.555 |
BMX |
0.644 | -0.016 | -1 | 0.499 |
KDR |
0.644 | -0.013 | 3 | 0.706 |
ITK |
0.644 | -0.040 | -1 | 0.538 |
TEC |
0.644 | -0.028 | -1 | 0.482 |
SBK |
0.643 | -0.106 | -3 | 0.370 |
ZAP70 |
0.643 | 0.108 | -1 | 0.528 |
ERBB2 |
0.643 | 0.034 | 1 | 0.682 |
FRK |
0.643 | 0.051 | -1 | 0.629 |
MATK |
0.642 | 0.020 | -1 | 0.566 |
FLT3 |
0.642 | -0.054 | 3 | 0.743 |
FGFR2 |
0.642 | -0.049 | 3 | 0.743 |
FGFR4 |
0.641 | 0.062 | -1 | 0.598 |
YANK2 |
0.641 | 0.012 | 2 | 0.400 |
BIKE |
0.641 | -0.097 | 1 | 0.572 |
LYN |
0.640 | 0.007 | 3 | 0.665 |
PDGFRB |
0.640 | -0.094 | 3 | 0.747 |
JAK1 |
0.639 | -0.066 | 1 | 0.660 |
WEE1_TYR |
0.639 | -0.064 | -1 | 0.487 |
FGFR3 |
0.638 | 0.008 | 3 | 0.716 |
EPHA7 |
0.638 | -0.011 | 2 | 0.702 |
CRIK |
0.638 | -0.109 | -3 | 0.506 |
EPHA8 |
0.638 | 0.030 | -1 | 0.624 |
TNNI3K_TYR |
0.638 | -0.063 | 1 | 0.740 |
PTK6 |
0.637 | -0.110 | -1 | 0.492 |
EPHA5 |
0.637 | 0.026 | 2 | 0.665 |
SRC |
0.637 | 0.018 | -1 | 0.558 |
MERTK |
0.636 | -0.085 | 3 | 0.723 |
ERBB4 |
0.635 | 0.071 | 1 | 0.626 |
DDR1 |
0.635 | -0.198 | 4 | 0.790 |
NTRK3 |
0.635 | -0.045 | -1 | 0.561 |
ALK |
0.635 | -0.083 | 3 | 0.658 |
FLT4 |
0.634 | -0.022 | 3 | 0.710 |
NTRK1 |
0.634 | -0.086 | -1 | 0.570 |
FGFR1 |
0.634 | -0.092 | 3 | 0.710 |
NEK10_TYR |
0.633 | -0.134 | 1 | 0.623 |
BTK |
0.633 | -0.133 | -1 | 0.496 |
EPHA3 |
0.632 | -0.059 | 2 | 0.672 |
INSR |
0.632 | -0.062 | 3 | 0.675 |
EPHA2 |
0.632 | 0.027 | -1 | 0.600 |
LTK |
0.631 | -0.100 | 3 | 0.687 |
TEK |
0.630 | -0.114 | 3 | 0.682 |
TNK2 |
0.630 | -0.141 | 3 | 0.687 |
PDGFRA |
0.630 | -0.153 | 3 | 0.748 |
NTRK2 |
0.628 | -0.121 | 3 | 0.697 |
AXL |
0.627 | -0.172 | 3 | 0.717 |
CSK |
0.626 | -0.045 | 2 | 0.715 |
IGF1R |
0.626 | -0.021 | 3 | 0.613 |
PTK2B |
0.624 | -0.075 | -1 | 0.497 |
TNK1 |
0.621 | -0.216 | 3 | 0.734 |
MUSK |
0.621 | -0.055 | 1 | 0.575 |
AAK1 |
0.619 | -0.085 | 1 | 0.463 |
EPHA1 |
0.619 | -0.156 | 3 | 0.694 |
DDR2 |
0.615 | -0.149 | 3 | 0.678 |
FES |
0.606 | -0.079 | -1 | 0.478 |