Motif 392 (n=216)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A096LP49 | CCDC187 | S777 | ochoa | Coiled-coil domain-containing protein 187 | None |
| A0A0A0MRY4 | None | S581 | ochoa | Spermatogenesis-associated protein 13 | None |
| A0A0C4DH73 | IGKV1-12 | S36 | ochoa | Immunoglobulin kappa variable 1-12 | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}. |
| A0JNW5 | BLTP3B | S1409 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| B5ME19 | EIF3CL | S533 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| H0Y626 | None | S36 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| O14649 | KCNK3 | S373 | ochoa | Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:23169818, PubMed:26919430, PubMed:32499642, PubMed:36195757, PubMed:9312005). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (PubMed:22948150). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:23169818, PubMed:32499642). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In cerebellar granule cells, heteromeric KCNK3:KCNK9 channel may hyperpolarize the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, it may support high-frequency action potential firing and increased neuronal excitability (By similarity). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. Additionally, imparts chemosensitivity to type 1 cells in carotid bodies which respond to a decrease in arterial oxygen pressure or an increase in carbon dioxide pressure or pH to initiate adaptive changes in pulmonary ventilation (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity). In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation and adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:O35111, ECO:0000250|UniProtKB:O54912, ECO:0000269|PubMed:22948150, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:32499642, ECO:0000269|PubMed:36195757, ECO:0000269|PubMed:9312005}. |
| O14654 | IRS4 | S463 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14974 | PPP1R12A | S479 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O14980 | XPO1 | S391 | ochoa|psp | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15231 | ZNF185 | S132 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O43294 | TGFB1I1 | S83 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43815 | STRN | S383 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60269 | GPRIN2 | S26 | ochoa | G protein-regulated inducer of neurite outgrowth 2 (GRIN2) | May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}. |
| O60292 | SIPA1L3 | S1440 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60343 | TBC1D4 | S789 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60664 | PLIN3 | S93 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75143 | ATG13 | S480 | ochoa | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O75376 | NCOR1 | S999 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94913 | PCF11 | S1179 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95208 | EPN2 | S180 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| O95359 | TACC2 | S2576 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95361 | TRIM16 | S36 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
| O95630 | STAMBP | S245 | ochoa|psp | STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). {ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699, ECO:0000269|PubMed:34425109}. |
| P01611 | IGKV1D-12 | S36 | ochoa | Immunoglobulin kappa variable 1D-12 (Ig kappa chain V-I region Wes) | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}. |
| P02730 | SLC4A1 | S357 | ochoa | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P04637 | TP53 | S315 | ochoa|psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
| P07451 | CA3 | S50 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P07900 | HSP90AA1 | S602 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07947 | YES1 | S28 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P08069 | IGF1R | S1310 | ochoa|psp | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P08238 | HSP90AB1 | S594 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P15923 | TCF3 | S381 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P17948 | FLT1 | S1207 | ochoa | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| P18583 | SON | S1782 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18615 | NELFE | S115 | ochoa|psp | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P20138 | CD33 | S307 | ochoa | Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33) | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:11320212, PubMed:15597323). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:10887109, PubMed:28325905). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10206955, PubMed:10556798, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323). {ECO:0000269|PubMed:10206955, ECO:0000269|PubMed:10556798, ECO:0000269|PubMed:10611343, ECO:0000269|PubMed:10887109, ECO:0000269|PubMed:11320212, ECO:0000269|PubMed:15597323, ECO:0000269|PubMed:28325905, ECO:0000269|PubMed:7718872}. |
| P20810 | CAST | S563 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P23193 | TCEA1 | S107 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P23193 | TCEA1 | S137 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P23443 | RPS6KB1 | S401 | ochoa | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P27816 | MAP4 | S715 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29317 | EPHA2 | S577 | ochoa | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P31629 | HIVEP2 | S1050 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P34910 | EVI2B | S280 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35580 | MYH10 | S1939 | ochoa|psp | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P46777 | RPL5 | S187 | ochoa | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| P46937 | YAP1 | S105 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P47712 | PLA2G4A | S729 | ochoa | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P47736 | RAP1GAP | S458 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P48730 | CSNK1D | S384 | ochoa | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49023 | PXN | S137 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49674 | CSNK1E | S391 | ochoa | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}. |
| P50548 | ERF | S168 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P50747 | HLCS | S138 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P51116 | FXR2 | S639 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P53814 | SMTN | S502 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P54259 | ATN1 | S41 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P54259 | ATN1 | S103 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P54725 | RAD23A | S140 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P54821 | PRRX1 | S74 | ochoa | Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1) | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). {ECO:0000250|UniProtKB:P63013, ECO:0000269|PubMed:35589735}.; FUNCTION: [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. {ECO:0000250|UniProtKB:P63013}.; FUNCTION: [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. {ECO:0000250|UniProtKB:P63013}. |
| P98082 | DAB2 | S369 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q00341 | HDLBP | S624 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00653 | NFKB2 | S715 | psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01484 | ANK2 | S2250 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02156 | PRKCE | S336 | ochoa | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q02952 | AKAP12 | S917 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05469 | LIPE | S855 | ochoa|psp | Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH) | Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:15716583, PubMed:15955102, PubMed:19800417, PubMed:8812477). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:19800417). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). {ECO:0000250|UniProtKB:P15304, ECO:0000250|UniProtKB:P54310, ECO:0000269|PubMed:15716583, ECO:0000269|PubMed:15955102, ECO:0000269|PubMed:19800417, ECO:0000269|PubMed:8812477}. |
| Q12774 | ARHGEF5 | S452 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12802 | AKAP13 | S1690 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12815 | TROAP | S344 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12888 | TP53BP1 | S1437 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13207 | TBX2 | S386 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q13415 | ORC1 | S478 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13422 | IKZF1 | S298 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13469 | NFATC2 | S243 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13487 | SNAPC2 | S192 | ochoa | snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. |
| Q13526 | PIN1 | S43 | ochoa | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13541 | EIF4EBP1 | S44 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q13542 | EIF4EBP2 | S44 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q14134 | TRIM29 | S28 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14451 | GRB7 | S368 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14739 | LBR | S130 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q14766 | LTBP1 | S1415 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q15052 | ARHGEF6 | S124 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15149 | PLEC | S1446 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15696 | ZRSR2 | S356 | ochoa | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP) | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}. |
| Q16760 | DGKD | S668 | ochoa | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q2PPJ7 | RALGAPA2 | S375 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q2TB10 | ZNF800 | S464 | ochoa | Zinc finger protein 800 | May be involved in transcriptional regulation. |
| Q2YD98 | UVSSA | S478 | ochoa | UV-stimulated scaffold protein A | Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612, PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Acts as a key adapter that promotes recruitment of factors involved in TC-NER (PubMed:22466611, PubMed:22466612, PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II (PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II (PubMed:38316879). Not involved in processing oxidative damage (PubMed:22466612). {ECO:0000269|PubMed:22466610, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:32142649, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236}. |
| Q32MZ4 | LRRFIP1 | S735 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q5D1E8 | ZC3H12A | S366 | ochoa | Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) | Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:22561375, PubMed:26134560, PubMed:26320658). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q5D1E7, ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18364357, ECO:0000269|PubMed:19185603, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:22561375, ECO:0000269|PubMed:24048733, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:26134560, ECO:0000269|PubMed:26320658}.; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. {ECO:0000269|PubMed:23355615}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. {ECO:0000269|PubMed:24191027}. |
| Q5FWE3 | PRRT3 | S815 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5M775 | SPECC1 | S919 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5S007 | LRRK2 | S933 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5SQI0 | ATAT1 | S272 | ochoa | Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}. |
| Q5SYE7 | NHSL1 | S1474 | ochoa | NHS-like protein 1 | None |
| Q5T5C0 | STXBP5 | S904 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5T5P2 | KIAA1217 | S1650 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TC79 | ZBTB37 | S195 | ochoa | Zinc finger and BTB domain-containing protein 37 | May be involved in transcriptional regulation. |
| Q5VSL9 | STRIP1 | S341 | ochoa | Striatin-interacting protein 1 (Protein FAM40A) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}. |
| Q5VT25 | CDC42BPA | S1671 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VUA4 | ZNF318 | S143 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q658Y4 | FAM91A1 | S686 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6AI08 | HEATR6 | S670 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6GYQ0 | RALGAPA1 | S797 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6NZI2 | CAVIN1 | S169 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P2E9 | EDC4 | Y40 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P4F7 | ARHGAP11A | S875 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P996 | PDXDC1 | S695 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PGQ7 | BORA | S190 | ochoa | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6PKG0 | LARP1 | S548 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZN18 | AEBP2 | S148 | ochoa | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q7L9B9 | EEPD1 | S21 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7RTV3 | ZNF367 | S119 | ochoa | Zinc finger protein 367 (C2H2 zinc finger protein ZFF29) | Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. {ECO:0000269|PubMed:15344908}. |
| Q7Z2Z1 | TICRR | S940 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z401 | DENND4A | S1589 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z6Z7 | HUWE1 | S3160 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z7C8 | TAF8 | S280 | ochoa | Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250|UniProtKB:Q9EQH4, ECO:0000269|PubMed:14580349, ECO:0000269|PubMed:33795473}. |
| Q86SQ0 | PHLDB2 | S934 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86YR5 | GPSM1 | S471 | ochoa | G-protein-signaling modulator 1 (Activator of G-protein signaling 3) | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}. |
| Q86YV0 | RASAL3 | S166 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IV63 | VRK3 | S129 | ochoa|psp | Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3) | Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250|UniProtKB:Q8K3G5, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289, ECO:0000269|PubMed:25899223, ECO:0000269|PubMed:27346674, ECO:0000269|PubMed:27941812}. |
| Q8IVF2 | AHNAK2 | S5714 | ochoa | Protein AHNAK2 | None |
| Q8IVT2 | MISP | S473 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWU2 | LMTK2 | S672 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IZQ1 | WDFY3 | S2492 | ochoa | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}. |
| Q8N2Y8 | RUSC2 | S913 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8N573 | OXR1 | S443 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5Y2 | MSL3 | S407 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
| Q8N806 | UBR7 | S265 | ochoa | Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7) | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. {ECO:0000250}. |
| Q8N9M5 | TMEM102 | S216 | ochoa | Transmembrane protein 102 (Common beta-chain associated protein) (CBAP) | Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}. |
| Q8NFC6 | BOD1L1 | Y480 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFZ4 | NLGN2 | S720 | ochoa | Neuroligin-2 | Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q69ZK9}. |
| Q8NHM5 | KDM2B | S445 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8NI08 | NCOA7 | S365 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8NI27 | THOC2 | S1450 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TDB6 | DTX3L | S547 | ochoa | E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) | E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}. |
| Q8WW38 | ZFPM2 | S588 | ochoa | Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2) | Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}. |
| Q8WWI1 | LMO7 | S1593 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWW8 | GAB3 | S346 | ochoa | GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3) | None |
| Q8WYL5 | SSH1 | S583 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92667 | AKAP1 | S107 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q969I6 | SLC38A4 | S19 | ochoa | Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) | Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:19015196, ECO:0000269|PubMed:33928121}. |
| Q96B33 | CLDN23 | S206 | ochoa | Claudin-23 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}. |
| Q96HP0 | DOCK6 | S185 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96I25 | RBM17 | S229 | ochoa | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96JB2 | COG3 | S516 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96N67 | DOCK7 | S1432 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96N96 | SPATA13 | S78 | ochoa|psp | Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}. |
| Q96NY8 | NECTIN4 | S446 | ochoa | Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4] | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; FUNCTION: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}. |
| Q96QD8 | SLC38A2 | S19 | ochoa | Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) | Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity). {ECO:0000250|UniProtKB:Q8CFE6, ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15774260, ECO:0000269|PubMed:15922329, ECO:0000269|PubMed:16621798}. |
| Q96QT4 | TRPM7 | S1352 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RT1 | ERBIN | S667 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96S38 | RPS6KC1 | S642 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96T58 | SPEN | S3438 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99613 | EIF3C | S532 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99684 | GFI1 | S71 | ochoa | Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163) | Transcription repressor essential for hematopoiesis (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Functions in a cell-context and development-specific manner (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed:19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed:29651020). {ECO:0000250|UniProtKB:P70338, ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12778173, ECO:0000269|PubMed:16287849, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:19026687, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:20190815, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:29651020, ECO:0000269|PubMed:8754800}. |
| Q99759 | MAP3K3 | S316 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9BQ52 | ELAC2 | S215 | ochoa | Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:24703694}. |
| Q9BR39 | JPH2 | S164 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BRS8 | LARP6 | S58 | ochoa|psp | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
| Q9BUU2 | METTL22 | S134 | ochoa | Methyltransferase-like protein 22 (EC 2.1.1.-) | Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro). {ECO:0000269|PubMed:23349634}. |
| Q9BXB5 | OSBPL10 | S188 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BZ95 | NSD3 | S568 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9C0A6 | SETD5 | S541 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0K0 | BCL11B | S258 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H063 | MAF1 | S75 | ochoa|psp | Repressor of RNA polymerase III transcription MAF1 homolog | Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}. |
| Q9H1A4 | ANAPC1 | S341 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H1A4 | ANAPC1 | S362 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H1J1 | UPF3A | S339 | ochoa | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}. |
| Q9H2X6 | HIPK2 | S854 | ochoa | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H334 | FOXP1 | S292 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Q9H410 | DSN1 | S88 | ochoa | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9H4A3 | WNK1 | S185 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H7N4 | SCAF1 | S674 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HAU0 | PLEKHA5 | S374 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HBG7 | LY9 | S535 | ochoa | T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229) | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). {ECO:0000250|UniProtKB:Q01965, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}. |
| Q9HCD5 | NCOA5 | S164 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCM3 | KIAA1549 | S1926 | ochoa | UPF0606 protein KIAA1549 | May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}. |
| Q9HCS5 | EPB41L4A | S304 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NP98 | MYOZ1 | S82 | ochoa | Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ) | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Q9NQ75 | CASS4 | S289 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NR48 | ASH1L | S1191 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NSV4 | DIAPH3 | S26 | ochoa | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}. |
| Q9NVH2 | INTS7 | S338 | ochoa | Integrator complex subunit 7 (Int7) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q9NY59 | SMPD3 | S180 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NYL2 | MAP3K20 | S567 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P258 | RCC2 | S45 | ochoa | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}. |
| Q9UDT6 | CLIP2 | S209 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UGL1 | KDM5B | S1314 | ochoa | Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}. |
| Q9UJF2 | RASAL2 | S641 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UK61 | TASOR | S344 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UK61 | TASOR | S1200 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UMS6 | SYNPO2 | S1063 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UNZ2 | NSFL1C | S271 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPN4 | CEP131 | S47 | ochoa|psp | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UQB8 | BAIAP2 | S261 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9UQC2 | GAB2 | S148 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y2F5 | ICE1 | S1699 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2J4 | AMOTL2 | S181 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2J4 | AMOTL2 | S537 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2U8 | LEMD3 | S409 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3M2 | CBY1 | S20 | ochoa|psp | Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1) | Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors (PubMed:12712206, PubMed:19435523). Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins (PubMed:15194699). Promotes adipocyte and cardiomyocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q9D1C2, ECO:0000269|PubMed:12712206, ECO:0000269|PubMed:15194699, ECO:0000269|PubMed:19435523}. |
| Q9Y487 | ATP6V0A2 | S159 | ochoa | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}. |
| Q9Y6J0 | CABIN1 | S1473 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q15007 | WTAP | S283 | Sugiyama | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). {ECO:0000269|PubMed:12444081, ECO:0000269|PubMed:17088532, ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| P36871 | PGM1 | S485 | Sugiyama | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| Q53QZ3 | ARHGAP15 | S41 | PSP | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q9C0C2 | TNKS1BP1 | S1110 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| Q9NWS0 | PIH1D1 | S175 | Sugiyama | PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog) | Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}. |
| Q8N5S9 | CAMKK1 | S69 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| O95425 | SVIL | S228 | Sugiyama | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| Q9H7E2 | TDRD3 | S367 | Sugiyama | Tudor domain-containing protein 3 | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}. |
| Q9UQ07 | MOK | S317 | Sugiyama | MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) | Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-162582 | Signal Transduction | 0.000067 | 4.176 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.001565 | 2.806 |
| R-HSA-6804754 | Regulation of TP53 Expression | 0.001565 | 2.806 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.001565 | 2.806 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.001565 | 2.806 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.001565 | 2.806 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.001565 | 2.806 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.001565 | 2.806 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.001565 | 2.806 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.001565 | 2.806 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.001565 | 2.806 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.001565 | 2.806 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.001565 | 2.806 |
| R-HSA-69275 | G2/M Transition | 0.000834 | 3.079 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.000897 | 3.047 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.002260 | 2.646 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.003148 | 2.502 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.004582 | 2.339 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.004944 | 2.306 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.005261 | 2.279 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.006029 | 2.220 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.007110 | 2.148 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.009246 | 2.034 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.012199 | 1.914 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.012336 | 1.909 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.013069 | 1.884 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.013069 | 1.884 |
| R-HSA-9723907 | Loss of Function of TP53 in Cancer | 0.014182 | 1.848 |
| R-HSA-9723905 | Loss of function of TP53 in cancer due to loss of tetramerization ability | 0.014182 | 1.848 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.015195 | 1.818 |
| R-HSA-4839726 | Chromatin organization | 0.016151 | 1.792 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.028164 | 1.550 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 0.041948 | 1.377 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.041948 | 1.377 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.041948 | 1.377 |
| R-HSA-1299316 | TWIK-releated acid-sensitive K+ channel (TASK) | 0.041948 | 1.377 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.068935 | 1.162 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.082144 | 1.085 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.082144 | 1.085 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.108003 | 0.967 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.108003 | 0.967 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.025038 | 1.601 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.120660 | 0.918 |
| R-HSA-9645135 | STAT5 Activation | 0.120660 | 0.918 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.120660 | 0.918 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.133137 | 0.876 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.133137 | 0.876 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.133137 | 0.876 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.145439 | 0.837 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.145439 | 0.837 |
| R-HSA-111995 | phospho-PLA2 pathway | 0.145439 | 0.837 |
| R-HSA-196025 | Formation of annular gap junctions | 0.145439 | 0.837 |
| R-HSA-9613354 | Lipophagy | 0.157566 | 0.803 |
| R-HSA-190873 | Gap junction degradation | 0.157566 | 0.803 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.157566 | 0.803 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.169523 | 0.771 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.192931 | 0.715 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.204387 | 0.690 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.081481 | 1.089 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.081481 | 1.089 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.085713 | 1.067 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.085713 | 1.067 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.019588 | 1.708 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.019588 | 1.708 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.022375 | 1.650 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.237794 | 0.624 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.237794 | 0.624 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.248616 | 0.604 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.248616 | 0.604 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.029776 | 1.526 |
| R-HSA-380287 | Centrosome maturation | 0.032127 | 1.493 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.259285 | 0.586 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.269804 | 0.569 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.269804 | 0.569 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.145728 | 0.836 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.290397 | 0.537 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.290397 | 0.537 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.290397 | 0.537 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.051557 | 1.288 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.300475 | 0.522 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.310411 | 0.508 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.310411 | 0.508 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.310411 | 0.508 |
| R-HSA-72187 | mRNA 3'-end processing | 0.211723 | 0.674 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.211723 | 0.674 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.152355 | 0.817 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.152355 | 0.817 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.232623 | 0.633 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.243123 | 0.614 |
| R-HSA-2029481 | FCGR activation | 0.183524 | 0.736 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.300983 | 0.521 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.295736 | 0.529 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.215682 | 0.666 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.054759 | 1.262 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.155731 | 0.808 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.126259 | 0.899 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.061392 | 1.212 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.145728 | 0.836 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.192931 | 0.715 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.259285 | 0.586 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.226816 | 0.644 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.261415 | 0.583 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.140844 | 0.851 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.261415 | 0.583 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.043365 | 1.363 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.021545 | 1.667 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.061392 | 1.212 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.082144 | 1.085 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.022386 | 1.650 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.030704 | 1.513 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.036822 | 1.434 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.081481 | 1.089 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.215682 | 0.666 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.216933 | 0.664 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.274703 | 0.561 |
| R-HSA-167169 | HIV Transcription Elongation | 0.145728 | 0.836 |
| R-HSA-4641265 | Repression of WNT target genes | 0.204387 | 0.690 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.076150 | 1.118 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.197886 | 0.704 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.248616 | 0.604 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.027812 | 1.556 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.120660 | 0.918 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.157566 | 0.803 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.269804 | 0.569 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.280173 | 0.553 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.185898 | 0.731 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.188312 | 0.725 |
| R-HSA-9664407 | Parasite infection | 0.188312 | 0.725 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.188312 | 0.725 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.250969 | 0.600 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.263394 | 0.579 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.234856 | 0.629 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.021937 | 1.659 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.284473 | 0.546 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.284473 | 0.546 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.082144 | 1.085 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.082144 | 1.085 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.095165 | 1.022 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.108003 | 0.967 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.133137 | 0.876 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.204387 | 0.690 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.259285 | 0.586 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.237870 | 0.624 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.077799 | 1.109 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.025822 | 1.588 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.107796 | 0.967 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.150648 | 0.822 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.259285 | 0.586 |
| R-HSA-163560 | Triglyceride catabolism | 0.126418 | 0.898 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.037434 | 1.427 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.055538 | 1.255 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.055538 | 1.255 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.022386 | 1.650 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.108003 | 0.967 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.157566 | 0.803 |
| R-HSA-192905 | vRNP Assembly | 0.181310 | 0.742 |
| R-HSA-202670 | ERKs are inactivated | 0.192931 | 0.715 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.248616 | 0.604 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.259285 | 0.586 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.243123 | 0.614 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.258906 | 0.587 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.321896 | 0.492 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.280616 | 0.552 |
| R-HSA-167172 | Transcription of the HIV genome | 0.295736 | 0.529 |
| R-HSA-9707616 | Heme signaling | 0.264172 | 0.578 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.087896 | 1.056 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.248616 | 0.604 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.327101 | 0.485 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.140844 | 0.851 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.327104 | 0.485 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.264488 | 0.578 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.107796 | 0.967 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.057609 | 1.240 |
| R-HSA-3371511 | HSF1 activation | 0.126418 | 0.898 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.290397 | 0.537 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.098914 | 1.005 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.088207 | 1.054 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.085182 | 1.070 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.098914 | 1.005 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.094370 | 1.025 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.082144 | 1.085 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.108003 | 0.967 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.133137 | 0.876 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.169523 | 0.771 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.074700 | 1.127 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.079866 | 1.098 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.155600 | 0.808 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.300475 | 0.522 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.201344 | 0.696 |
| R-HSA-196780 | Biotin transport and metabolism | 0.237794 | 0.624 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.047876 | 1.320 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.025038 | 1.601 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.073222 | 1.135 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.226816 | 0.644 |
| R-HSA-8979227 | Triglyceride metabolism | 0.248381 | 0.605 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.121692 | 0.915 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.114864 | 0.940 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.179979 | 0.745 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.244805 | 0.611 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.082144 | 1.085 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.108003 | 0.967 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.027812 | 1.556 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.030704 | 1.513 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.181310 | 0.742 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.192931 | 0.715 |
| R-HSA-1483115 | Hydrolysis of LPC | 0.226816 | 0.644 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.259285 | 0.586 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.259285 | 0.586 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.077264 | 1.112 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.264172 | 0.578 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.321896 | 0.492 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.327101 | 0.485 |
| R-HSA-68877 | Mitotic Prometaphase | 0.033923 | 1.469 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.326896 | 0.486 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.069201 | 1.160 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.078098 | 1.107 |
| R-HSA-9612973 | Autophagy | 0.238676 | 0.622 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.303818 | 0.517 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.269438 | 0.570 |
| R-HSA-2028269 | Signaling by Hippo | 0.040042 | 1.397 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.145439 | 0.837 |
| R-HSA-9658195 | Leishmania infection | 0.262095 | 0.582 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.262095 | 0.582 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.185898 | 0.731 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.213189 | 0.671 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.214555 | 0.668 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.157566 | 0.803 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.259285 | 0.586 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.145728 | 0.836 |
| R-HSA-5260271 | Diseases of Immune System | 0.145728 | 0.836 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.180787 | 0.743 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.046786 | 1.330 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.043365 | 1.363 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.043365 | 1.363 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.248381 | 0.605 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.055538 | 1.255 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.108003 | 0.967 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.157566 | 0.803 |
| R-HSA-425381 | Bicarbonate transporters | 0.181310 | 0.742 |
| R-HSA-8853659 | RET signaling | 0.024349 | 1.614 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.085713 | 1.067 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.215682 | 0.666 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.290397 | 0.537 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.206527 | 0.685 |
| R-HSA-68882 | Mitotic Anaphase | 0.124289 | 0.906 |
| R-HSA-74160 | Gene expression (Transcription) | 0.204549 | 0.689 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.126072 | 0.899 |
| R-HSA-165159 | MTOR signalling | 0.160583 | 0.794 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.323221 | 0.491 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.323221 | 0.491 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.053912 | 1.268 |
| R-HSA-3214842 | HDMs demethylate histones | 0.073222 | 1.135 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.090010 | 1.046 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.145728 | 0.836 |
| R-HSA-194138 | Signaling by VEGF | 0.142018 | 0.848 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.169523 | 0.771 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.032179 | 1.492 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.280616 | 0.552 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.112379 | 0.949 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.090646 | 1.043 |
| R-HSA-111996 | Ca-dependent events | 0.160583 | 0.794 |
| R-HSA-2559583 | Cellular Senescence | 0.317271 | 0.499 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.323221 | 0.491 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.238968 | 0.622 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.180787 | 0.743 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.180787 | 0.743 |
| R-HSA-1640170 | Cell Cycle | 0.017869 | 1.748 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.018929 | 1.723 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.290484 | 0.537 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.095165 | 1.022 |
| R-HSA-8964011 | HDL clearance | 0.120660 | 0.918 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.030704 | 1.513 |
| R-HSA-448706 | Interleukin-1 processing | 0.157566 | 0.803 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.204387 | 0.690 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.204387 | 0.690 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.204387 | 0.690 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.226816 | 0.644 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.237794 | 0.624 |
| R-HSA-3371568 | Attenuation phase | 0.145728 | 0.836 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.185898 | 0.731 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.248381 | 0.605 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.197886 | 0.704 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.249978 | 0.602 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.048084 | 1.318 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.221504 | 0.655 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.126418 | 0.898 |
| R-HSA-112043 | PLC beta mediated events | 0.258906 | 0.587 |
| R-HSA-68886 | M Phase | 0.065674 | 1.183 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.248616 | 0.604 |
| R-HSA-5617833 | Cilium Assembly | 0.181135 | 0.742 |
| R-HSA-622312 | Inflammasomes | 0.085713 | 1.067 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.030828 | 1.511 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.108003 | 0.967 |
| R-HSA-5689877 | Josephin domain DUBs | 0.169523 | 0.771 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 0.169523 | 0.771 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.204387 | 0.690 |
| R-HSA-5578768 | Physiological factors | 0.226816 | 0.644 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.259285 | 0.586 |
| R-HSA-70370 | Galactose catabolism | 0.259285 | 0.586 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.280173 | 0.553 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 0.300475 | 0.522 |
| R-HSA-8939211 | ESR-mediated signaling | 0.306623 | 0.513 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.160583 | 0.794 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.327101 | 0.485 |
| R-HSA-8848021 | Signaling by PTK6 | 0.269438 | 0.570 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.269438 | 0.570 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.215682 | 0.666 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.201519 | 0.696 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.232584 | 0.633 |
| R-HSA-112040 | G-protein mediated events | 0.290484 | 0.537 |
| R-HSA-210990 | PECAM1 interactions | 0.181310 | 0.742 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.094370 | 1.025 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.064839 | 1.188 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.290397 | 0.537 |
| R-HSA-392517 | Rap1 signalling | 0.290397 | 0.537 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.300475 | 0.522 |
| R-HSA-198753 | ERK/MAPK targets | 0.310411 | 0.508 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.175699 | 0.755 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.327101 | 0.485 |
| R-HSA-9834899 | Specification of the neural plate border | 0.290397 | 0.537 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.306223 | 0.514 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.184606 | 0.734 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 0.095165 | 1.022 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.081481 | 1.089 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.290397 | 0.537 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.101996 | 0.991 |
| R-HSA-422475 | Axon guidance | 0.189055 | 0.723 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.204387 | 0.690 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.094561 | 1.024 |
| R-HSA-9675108 | Nervous system development | 0.157065 | 0.804 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.165595 | 0.781 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.064991 | 1.187 |
| R-HSA-8876725 | Protein methylation | 0.237794 | 0.624 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.248616 | 0.604 |
| R-HSA-5635838 | Activation of SMO | 0.248616 | 0.604 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.259285 | 0.586 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.280173 | 0.553 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.274703 | 0.561 |
| R-HSA-446728 | Cell junction organization | 0.137140 | 0.863 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.216202 | 0.665 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.157566 | 0.803 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.069690 | 1.157 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 0.310411 | 0.508 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.320206 | 0.495 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.123120 | 0.910 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.020788 | 1.682 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.261706 | 0.582 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.096726 | 1.014 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.146672 | 0.834 |
| R-HSA-1500931 | Cell-Cell communication | 0.207287 | 0.683 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.043365 | 1.363 |
| R-HSA-180292 | GAB1 signalosome | 0.280173 | 0.553 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.018929 | 1.723 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.205167 | 0.688 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.205167 | 0.688 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.205167 | 0.688 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.226816 | 0.644 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.320206 | 0.495 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.105616 | 0.976 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.112519 | 0.949 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.201519 | 0.696 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.296070 | 0.529 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.296070 | 0.529 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.307695 | 0.512 |
| R-HSA-5218859 | Regulated Necrosis | 0.295736 | 0.529 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.307695 | 0.512 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.264172 | 0.578 |
| R-HSA-373755 | Semaphorin interactions | 0.082505 | 1.084 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.126418 | 0.898 |
| R-HSA-210993 | Tie2 Signaling | 0.280173 | 0.553 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.242397 | 0.615 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.250969 | 0.600 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.126259 | 0.899 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.242397 | 0.615 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.094758 | 1.023 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.119018 | 0.924 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.110861 | 0.955 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.248381 | 0.605 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.290484 | 0.537 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.220522 | 0.657 |
| R-HSA-3322077 | Glycogen synthesis | 0.300475 | 0.522 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.179807 | 0.745 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.172946 | 0.762 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.028907 | 1.539 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.208831 | 0.680 |
| R-HSA-73887 | Death Receptor Signaling | 0.232584 | 0.633 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.211723 | 0.674 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.329863 | 0.482 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.329863 | 0.482 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.329863 | 0.482 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.329863 | 0.482 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.329863 | 0.482 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.329863 | 0.482 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.329863 | 0.482 |
| R-HSA-69481 | G2/M Checkpoints | 0.330986 | 0.480 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.332297 | 0.478 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.339384 | 0.469 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.339384 | 0.469 |
| R-HSA-8953854 | Metabolism of RNA | 0.340236 | 0.468 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.347811 | 0.459 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.347811 | 0.459 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.348769 | 0.457 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.348769 | 0.457 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.348769 | 0.457 |
| R-HSA-429947 | Deadenylation of mRNA | 0.348769 | 0.457 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.348769 | 0.457 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.348769 | 0.457 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.348769 | 0.457 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.352639 | 0.453 |
| R-HSA-9909396 | Circadian clock | 0.354259 | 0.451 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.355860 | 0.449 |
| R-HSA-420029 | Tight junction interactions | 0.358022 | 0.446 |
| R-HSA-9839394 | TGFBR3 expression | 0.358022 | 0.446 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.358022 | 0.446 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.358022 | 0.446 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.358022 | 0.446 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.358022 | 0.446 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.358022 | 0.446 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.358088 | 0.446 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.358555 | 0.445 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.367144 | 0.435 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.367144 | 0.435 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.367144 | 0.435 |
| R-HSA-525793 | Myogenesis | 0.367144 | 0.435 |
| R-HSA-3295583 | TRP channels | 0.367144 | 0.435 |
| R-HSA-70635 | Urea cycle | 0.367144 | 0.435 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.367144 | 0.435 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.367144 | 0.435 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.373392 | 0.428 |
| R-HSA-168249 | Innate Immune System | 0.374538 | 0.427 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.376137 | 0.425 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.376137 | 0.425 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.376137 | 0.425 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.378461 | 0.422 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.385003 | 0.415 |
| R-HSA-77387 | Insulin receptor recycling | 0.385003 | 0.415 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.385003 | 0.415 |
| R-HSA-5620971 | Pyroptosis | 0.385003 | 0.415 |
| R-HSA-6807070 | PTEN Regulation | 0.385122 | 0.414 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.392434 | 0.406 |
| R-HSA-1632852 | Macroautophagy | 0.392790 | 0.406 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.393743 | 0.405 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.393743 | 0.405 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.393743 | 0.405 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.400434 | 0.397 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.400434 | 0.397 |
| R-HSA-5357801 | Programmed Cell Death | 0.400858 | 0.397 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.402359 | 0.395 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.402359 | 0.395 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.402359 | 0.395 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.402359 | 0.395 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.402359 | 0.395 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.402359 | 0.395 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.402359 | 0.395 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.402359 | 0.395 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 0.403539 | 0.394 |
| R-HSA-9663891 | Selective autophagy | 0.403539 | 0.394 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.403539 | 0.394 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.405302 | 0.392 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.410854 | 0.386 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.410854 | 0.386 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.410854 | 0.386 |
| R-HSA-186763 | Downstream signal transduction | 0.410854 | 0.386 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.419228 | 0.378 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.419228 | 0.378 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.419228 | 0.378 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.419422 | 0.377 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.424368 | 0.372 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.427484 | 0.369 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.427484 | 0.369 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.427484 | 0.369 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.427484 | 0.369 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.427484 | 0.369 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.427484 | 0.369 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.427484 | 0.369 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.428130 | 0.368 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.430721 | 0.366 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.432985 | 0.364 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.432985 | 0.364 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.435623 | 0.361 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.435623 | 0.361 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.435623 | 0.361 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.435623 | 0.361 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.437818 | 0.359 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.438210 | 0.358 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.443647 | 0.353 |
| R-HSA-203615 | eNOS activation | 0.443647 | 0.353 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.443647 | 0.353 |
| R-HSA-392518 | Signal amplification | 0.443647 | 0.353 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.443647 | 0.353 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.447416 | 0.349 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.447416 | 0.349 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.451557 | 0.345 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.451557 | 0.345 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.451557 | 0.345 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.451557 | 0.345 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.451557 | 0.345 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.452181 | 0.345 |
| R-HSA-162587 | HIV Life Cycle | 0.456767 | 0.340 |
| R-HSA-1280218 | Adaptive Immune System | 0.457297 | 0.340 |
| R-HSA-1266738 | Developmental Biology | 0.458609 | 0.339 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.459355 | 0.338 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.459355 | 0.338 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.459355 | 0.338 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.459355 | 0.338 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.459355 | 0.338 |
| R-HSA-111933 | Calmodulin induced events | 0.459355 | 0.338 |
| R-HSA-111997 | CaM pathway | 0.459355 | 0.338 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.467043 | 0.331 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.467157 | 0.331 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.468672 | 0.329 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.474622 | 0.324 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 0.474622 | 0.324 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.474622 | 0.324 |
| R-HSA-1566948 | Elastic fibre formation | 0.474622 | 0.324 |
| R-HSA-8875878 | MET promotes cell motility | 0.474622 | 0.324 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.474622 | 0.324 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.474622 | 0.324 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.474622 | 0.324 |
| R-HSA-109581 | Apoptosis | 0.475064 | 0.323 |
| R-HSA-109582 | Hemostasis | 0.481450 | 0.317 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.482094 | 0.317 |
| R-HSA-69541 | Stabilization of p53 | 0.482094 | 0.317 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.482094 | 0.317 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.482094 | 0.317 |
| R-HSA-72312 | rRNA processing | 0.485645 | 0.314 |
| R-HSA-199991 | Membrane Trafficking | 0.486885 | 0.313 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.489436 | 0.310 |
| R-HSA-111885 | Opioid Signalling | 0.489436 | 0.310 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.489459 | 0.310 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.489459 | 0.310 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.489459 | 0.310 |
| R-HSA-9646399 | Aggrephagy | 0.489459 | 0.310 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.489459 | 0.310 |
| R-HSA-8982491 | Glycogen metabolism | 0.489459 | 0.310 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.496721 | 0.304 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.496721 | 0.304 |
| R-HSA-9607240 | FLT3 Signaling | 0.496721 | 0.304 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.496721 | 0.304 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.500856 | 0.300 |
| R-HSA-166786 | Creation of C4 and C2 activators | 0.502994 | 0.298 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.503880 | 0.298 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.507264 | 0.295 |
| R-HSA-69239 | Synthesis of DNA | 0.507462 | 0.295 |
| R-HSA-211000 | Gene Silencing by RNA | 0.507462 | 0.295 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.510779 | 0.292 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.510937 | 0.292 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.511904 | 0.291 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.511904 | 0.291 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.511904 | 0.291 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.514281 | 0.289 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.516319 | 0.287 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.517770 | 0.286 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.517770 | 0.286 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.518394 | 0.285 |
| R-HSA-190828 | Gap junction trafficking | 0.524753 | 0.280 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.524753 | 0.280 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.524753 | 0.280 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.529407 | 0.276 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.531515 | 0.274 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.531515 | 0.274 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.531515 | 0.274 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.531515 | 0.274 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.538180 | 0.269 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.538180 | 0.269 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.538180 | 0.269 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.538180 | 0.269 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.538180 | 0.269 |
| R-HSA-75153 | Apoptotic execution phase | 0.538180 | 0.269 |
| R-HSA-168255 | Influenza Infection | 0.538416 | 0.269 |
| R-HSA-166663 | Initial triggering of complement | 0.542253 | 0.266 |
| R-HSA-421270 | Cell-cell junction organization | 0.542361 | 0.266 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.544752 | 0.264 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.546481 | 0.262 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.551230 | 0.259 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.551230 | 0.259 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.556756 | 0.254 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.557617 | 0.254 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.557617 | 0.254 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.557617 | 0.254 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.557617 | 0.254 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.563120 | 0.249 |
| R-HSA-109704 | PI3K Cascade | 0.563913 | 0.249 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.567211 | 0.246 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.568422 | 0.245 |
| R-HSA-9864848 | Complex IV assembly | 0.570119 | 0.244 |
| R-HSA-983712 | Ion channel transport | 0.571681 | 0.243 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.573631 | 0.241 |
| R-HSA-3371556 | Cellular response to heat stress | 0.575310 | 0.240 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.576238 | 0.239 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.576238 | 0.239 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.576238 | 0.239 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.576238 | 0.239 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.576238 | 0.239 |
| R-HSA-449147 | Signaling by Interleukins | 0.577068 | 0.239 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.582270 | 0.235 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.582270 | 0.235 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.582270 | 0.235 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.582270 | 0.235 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.583299 | 0.234 |
| R-HSA-72649 | Translation initiation complex formation | 0.588217 | 0.230 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.588217 | 0.230 |
| R-HSA-977606 | Regulation of Complement cascade | 0.591177 | 0.228 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.594079 | 0.226 |
| R-HSA-418597 | G alpha (z) signalling events | 0.594079 | 0.226 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.594079 | 0.226 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.594079 | 0.226 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.594079 | 0.226 |
| R-HSA-69206 | G1/S Transition | 0.595075 | 0.225 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.599858 | 0.222 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.599858 | 0.222 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.599858 | 0.222 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.599858 | 0.222 |
| R-HSA-177929 | Signaling by EGFR | 0.599858 | 0.222 |
| R-HSA-75893 | TNF signaling | 0.599858 | 0.222 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.605556 | 0.218 |
| R-HSA-1483166 | Synthesis of PA | 0.605556 | 0.218 |
| R-HSA-112399 | IRS-mediated signalling | 0.605556 | 0.218 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.606521 | 0.217 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.606521 | 0.217 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.611172 | 0.214 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.612651 | 0.213 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.614146 | 0.212 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.616709 | 0.210 |
| R-HSA-5576891 | Cardiac conduction | 0.621581 | 0.207 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.622167 | 0.206 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.622167 | 0.206 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.622167 | 0.206 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.622167 | 0.206 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.622167 | 0.206 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.622167 | 0.206 |
| R-HSA-450294 | MAP kinase activation | 0.627548 | 0.202 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.632853 | 0.199 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.632853 | 0.199 |
| R-HSA-186797 | Signaling by PDGF | 0.632853 | 0.199 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.632853 | 0.199 |
| R-HSA-73894 | DNA Repair | 0.633795 | 0.198 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.638082 | 0.195 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.643224 | 0.192 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.643238 | 0.192 |
| R-HSA-397014 | Muscle contraction | 0.645215 | 0.190 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.648320 | 0.188 |
| R-HSA-418990 | Adherens junctions interactions | 0.662148 | 0.179 |
| R-HSA-195721 | Signaling by WNT | 0.667301 | 0.176 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.670552 | 0.174 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.672670 | 0.172 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.672670 | 0.172 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.672670 | 0.172 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.672670 | 0.172 |
| R-HSA-448424 | Interleukin-17 signaling | 0.672670 | 0.172 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.673847 | 0.171 |
| R-HSA-166658 | Complement cascade | 0.677115 | 0.169 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.677334 | 0.169 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.677334 | 0.169 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.677334 | 0.169 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.677334 | 0.169 |
| R-HSA-8978934 | Metabolism of cofactors | 0.677334 | 0.169 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.677334 | 0.169 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.677334 | 0.169 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.677334 | 0.169 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.680357 | 0.167 |
| R-HSA-6798695 | Neutrophil degranulation | 0.680386 | 0.167 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.681933 | 0.166 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.681933 | 0.166 |
| R-HSA-162906 | HIV Infection | 0.686442 | 0.163 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.686466 | 0.163 |
| R-HSA-4086398 | Ca2+ pathway | 0.686466 | 0.163 |
| R-HSA-69242 | S Phase | 0.686761 | 0.163 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.689060 | 0.162 |
| R-HSA-9758941 | Gastrulation | 0.689923 | 0.161 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.690935 | 0.161 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.691661 | 0.160 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.695340 | 0.158 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.695340 | 0.158 |
| R-HSA-917937 | Iron uptake and transport | 0.695340 | 0.158 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.699253 | 0.155 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.699253 | 0.155 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.699683 | 0.155 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.699683 | 0.155 |
| R-HSA-69306 | DNA Replication | 0.702311 | 0.153 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.702311 | 0.153 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.705344 | 0.152 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.708185 | 0.150 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.708350 | 0.150 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.712345 | 0.147 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.716447 | 0.145 |
| R-HSA-6806834 | Signaling by MET | 0.716447 | 0.145 |
| R-HSA-9833482 | PKR-mediated signaling | 0.716447 | 0.145 |
| R-HSA-157118 | Signaling by NOTCH | 0.719204 | 0.143 |
| R-HSA-877300 | Interferon gamma signaling | 0.720123 | 0.143 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.720490 | 0.142 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.720490 | 0.142 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.724476 | 0.140 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.724476 | 0.140 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.728405 | 0.138 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.732279 | 0.135 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.736097 | 0.133 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.736097 | 0.133 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.736097 | 0.133 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.739861 | 0.131 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.747230 | 0.127 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.747230 | 0.127 |
| R-HSA-156902 | Peptide chain elongation | 0.750836 | 0.124 |
| R-HSA-5688426 | Deubiquitination | 0.753650 | 0.123 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.757896 | 0.120 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.761350 | 0.118 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.761350 | 0.118 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.764756 | 0.116 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.768113 | 0.115 |
| R-HSA-391251 | Protein folding | 0.768113 | 0.115 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.768113 | 0.115 |
| R-HSA-1474290 | Collagen formation | 0.774685 | 0.111 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.777901 | 0.109 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.781071 | 0.107 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.781071 | 0.107 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.784196 | 0.106 |
| R-HSA-1296071 | Potassium Channels | 0.784196 | 0.106 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.790314 | 0.102 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.791222 | 0.102 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.792334 | 0.101 |
| R-HSA-3214847 | HATs acetylate histones | 0.793308 | 0.101 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.799169 | 0.097 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.802037 | 0.096 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.802037 | 0.096 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.802037 | 0.096 |
| R-HSA-1483255 | PI Metabolism | 0.802037 | 0.096 |
| R-HSA-192823 | Viral mRNA Translation | 0.804864 | 0.094 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.807651 | 0.093 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.807651 | 0.093 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.810398 | 0.091 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.810398 | 0.091 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.813165 | 0.090 |
| R-HSA-418346 | Platelet homeostasis | 0.815777 | 0.088 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.818408 | 0.087 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.821003 | 0.086 |
| R-HSA-168256 | Immune System | 0.825672 | 0.083 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.826956 | 0.083 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.826956 | 0.083 |
| R-HSA-1483257 | Phospholipid metabolism | 0.829096 | 0.081 |
| R-HSA-913531 | Interferon Signaling | 0.830598 | 0.081 |
| R-HSA-72172 | mRNA Splicing | 0.830725 | 0.081 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.833431 | 0.079 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.835812 | 0.078 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.835812 | 0.078 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.838159 | 0.077 |
| R-HSA-373760 | L1CAM interactions | 0.845000 | 0.073 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.847216 | 0.072 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.847216 | 0.072 |
| R-HSA-5693538 | Homology Directed Repair | 0.849401 | 0.071 |
| R-HSA-68875 | Mitotic Prophase | 0.853677 | 0.069 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.859865 | 0.066 |
| R-HSA-8951664 | Neddylation | 0.859897 | 0.066 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.861869 | 0.065 |
| R-HSA-212436 | Generic Transcription Pathway | 0.866906 | 0.062 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.871471 | 0.060 |
| R-HSA-9843745 | Adipogenesis | 0.878671 | 0.056 |
| R-HSA-1474244 | Extracellular matrix organization | 0.879225 | 0.056 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.880408 | 0.055 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.880408 | 0.055 |
| R-HSA-388396 | GPCR downstream signalling | 0.884455 | 0.053 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.888725 | 0.051 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.891889 | 0.050 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.891889 | 0.050 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.896993 | 0.047 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.899041 | 0.046 |
| R-HSA-166520 | Signaling by NTRKs | 0.907754 | 0.042 |
| R-HSA-2142753 | Arachidonate metabolism | 0.912929 | 0.040 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.913359 | 0.039 |
| R-HSA-416476 | G alpha (q) signalling events | 0.914362 | 0.039 |
| R-HSA-9679506 | SARS-CoV Infections | 0.916527 | 0.038 |
| R-HSA-1989781 | PPARA activates gene expression | 0.916619 | 0.038 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.918269 | 0.037 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.918993 | 0.037 |
| R-HSA-9711097 | Cellular response to starvation | 0.920154 | 0.036 |
| R-HSA-112316 | Neuronal System | 0.920611 | 0.036 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.926782 | 0.033 |
| R-HSA-5619102 | SLC transporter disorders | 0.929888 | 0.032 |
| R-HSA-2262752 | Cellular responses to stress | 0.931351 | 0.031 |
| R-HSA-72306 | tRNA processing | 0.933826 | 0.030 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.936177 | 0.029 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.936634 | 0.028 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.936634 | 0.028 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.936634 | 0.028 |
| R-HSA-372790 | Signaling by GPCR | 0.936844 | 0.028 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.939040 | 0.027 |
| R-HSA-611105 | Respiratory electron transport | 0.941053 | 0.026 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.941274 | 0.026 |
| R-HSA-9824446 | Viral Infection Pathways | 0.941879 | 0.026 |
| R-HSA-418594 | G alpha (i) signalling events | 0.945153 | 0.024 |
| R-HSA-3781865 | Diseases of glycosylation | 0.945952 | 0.024 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.948718 | 0.023 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.953234 | 0.021 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.953268 | 0.021 |
| R-HSA-9609690 | HCMV Early Events | 0.954568 | 0.020 |
| R-HSA-72766 | Translation | 0.956659 | 0.019 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.957545 | 0.019 |
| R-HSA-428157 | Sphingolipid metabolism | 0.957741 | 0.019 |
| R-HSA-8957322 | Metabolism of steroids | 0.958056 | 0.019 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.964484 | 0.016 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.972643 | 0.012 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.974300 | 0.011 |
| R-HSA-382551 | Transport of small molecules | 0.976722 | 0.010 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.978625 | 0.009 |
| R-HSA-9609646 | HCMV Infection | 0.979537 | 0.009 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.981633 | 0.008 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.986380 | 0.006 |
| R-HSA-5668914 | Diseases of metabolism | 0.988481 | 0.005 |
| R-HSA-5663205 | Infectious disease | 0.993892 | 0.003 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.994565 | 0.002 |
| R-HSA-1643685 | Disease | 0.995028 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 0.996236 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997962 | 0.001 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.998993 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999052 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999505 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999631 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999948 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GRK1 |
0.823 | 0.388 | -2 | 0.487 |
COT |
0.815 | 0.181 | 2 | 0.821 |
KIS |
0.814 | 0.229 | 1 | 0.720 |
MOS |
0.810 | 0.309 | 1 | 0.881 |
CLK3 |
0.805 | 0.117 | 1 | 0.847 |
IKKB |
0.802 | 0.036 | -2 | 0.273 |
CDC7 |
0.801 | 0.080 | 1 | 0.859 |
BMPR1B |
0.800 | 0.206 | 1 | 0.843 |
PIM3 |
0.797 | 0.057 | -3 | 0.843 |
DSTYK |
0.793 | 0.095 | 2 | 0.818 |
GRK7 |
0.793 | 0.230 | 1 | 0.779 |
MTOR |
0.793 | 0.021 | 1 | 0.795 |
RAF1 |
0.793 | 0.038 | 1 | 0.833 |
SRPK1 |
0.791 | 0.081 | -3 | 0.792 |
IKKA |
0.791 | 0.042 | -2 | 0.279 |
NDR2 |
0.790 | 0.025 | -3 | 0.833 |
PRPK |
0.790 | -0.023 | -1 | 0.813 |
SKMLCK |
0.790 | 0.064 | -2 | 0.285 |
NLK |
0.789 | 0.040 | 1 | 0.845 |
HIPK4 |
0.789 | 0.047 | 1 | 0.817 |
CDKL1 |
0.788 | 0.048 | -3 | 0.837 |
AURC |
0.787 | -0.002 | -2 | 0.187 |
CAMK1B |
0.787 | -0.003 | -3 | 0.868 |
TGFBR2 |
0.785 | -0.006 | -2 | 0.309 |
CAMK2G |
0.785 | -0.009 | 2 | 0.779 |
GRK5 |
0.785 | 0.032 | -3 | 0.847 |
TGFBR1 |
0.785 | 0.091 | -2 | 0.330 |
GRK4 |
0.785 | 0.166 | -2 | 0.422 |
ERK5 |
0.784 | 0.011 | 1 | 0.810 |
BMPR2 |
0.783 | -0.053 | -2 | 0.299 |
GCN2 |
0.783 | -0.069 | 2 | 0.710 |
CDKL5 |
0.782 | 0.024 | -3 | 0.830 |
CHAK2 |
0.782 | -0.002 | -1 | 0.785 |
MST4 |
0.782 | 0.025 | 2 | 0.767 |
GRK2 |
0.782 | 0.111 | -2 | 0.369 |
CLK2 |
0.782 | 0.109 | -3 | 0.771 |
PIM1 |
0.782 | 0.035 | -3 | 0.806 |
RSK2 |
0.782 | 0.016 | -3 | 0.803 |
PDHK4 |
0.782 | -0.150 | 1 | 0.841 |
DYRK2 |
0.782 | 0.060 | 1 | 0.743 |
TBK1 |
0.781 | -0.066 | 1 | 0.717 |
HUNK |
0.781 | 0.062 | 2 | 0.753 |
IKKE |
0.780 | -0.061 | 1 | 0.719 |
ATR |
0.780 | -0.038 | 1 | 0.780 |
NUAK2 |
0.780 | 0.008 | -3 | 0.847 |
CK1E |
0.780 | 0.195 | -3 | 0.608 |
RIPK3 |
0.780 | 0.017 | 3 | 0.728 |
GRK6 |
0.780 | 0.047 | 1 | 0.844 |
MARK4 |
0.780 | -0.019 | 4 | 0.840 |
PRKX |
0.779 | 0.040 | -3 | 0.705 |
ICK |
0.779 | 0.015 | -3 | 0.862 |
BMPR1A |
0.779 | 0.123 | 1 | 0.821 |
CAMLCK |
0.778 | -0.027 | -2 | 0.255 |
NDR1 |
0.778 | -0.023 | -3 | 0.833 |
PKACG |
0.778 | -0.018 | -2 | 0.220 |
PKACB |
0.778 | 0.015 | -2 | 0.182 |
FAM20C |
0.778 | 0.039 | 2 | 0.607 |
GRK3 |
0.778 | 0.134 | -2 | 0.401 |
ALK2 |
0.778 | 0.117 | -2 | 0.356 |
NEK6 |
0.778 | -0.053 | -2 | 0.272 |
ACVR2B |
0.778 | 0.070 | -2 | 0.307 |
MLK1 |
0.778 | -0.012 | 2 | 0.711 |
NEK7 |
0.778 | -0.059 | -3 | 0.846 |
SRPK2 |
0.777 | 0.057 | -3 | 0.724 |
DAPK2 |
0.777 | -0.021 | -3 | 0.870 |
SRPK3 |
0.777 | 0.069 | -3 | 0.769 |
ULK2 |
0.777 | -0.137 | 2 | 0.683 |
PRKD1 |
0.777 | -0.032 | -3 | 0.826 |
CDK1 |
0.777 | 0.079 | 1 | 0.687 |
ALK4 |
0.776 | 0.048 | -2 | 0.326 |
PKN2 |
0.776 | -0.002 | -3 | 0.835 |
NIK |
0.776 | -0.058 | -3 | 0.866 |
WNK1 |
0.776 | -0.040 | -2 | 0.274 |
PDHK1 |
0.775 | -0.176 | 1 | 0.822 |
HIPK2 |
0.775 | 0.085 | 1 | 0.668 |
CK1D |
0.775 | 0.198 | -3 | 0.560 |
PKN3 |
0.774 | -0.022 | -3 | 0.832 |
PRKD2 |
0.774 | -0.013 | -3 | 0.781 |
AURA |
0.774 | -0.019 | -2 | 0.191 |
BCKDK |
0.774 | -0.062 | -1 | 0.764 |
ACVR2A |
0.774 | 0.031 | -2 | 0.293 |
AMPKA1 |
0.774 | -0.018 | -3 | 0.843 |
CLK4 |
0.774 | 0.037 | -3 | 0.797 |
MAPKAPK2 |
0.773 | 0.012 | -3 | 0.748 |
HIPK1 |
0.773 | 0.082 | 1 | 0.760 |
P90RSK |
0.773 | -0.012 | -3 | 0.806 |
JNK2 |
0.773 | 0.075 | 1 | 0.661 |
AURB |
0.772 | -0.032 | -2 | 0.183 |
RSK4 |
0.772 | 0.037 | -3 | 0.774 |
P70S6KB |
0.772 | -0.014 | -3 | 0.810 |
DLK |
0.771 | -0.030 | 1 | 0.817 |
PKCD |
0.771 | -0.027 | 2 | 0.685 |
CAMK2D |
0.771 | -0.065 | -3 | 0.835 |
CAMK2B |
0.771 | 0.002 | 2 | 0.772 |
MYLK4 |
0.771 | 0.007 | -2 | 0.242 |
DYRK4 |
0.771 | 0.075 | 1 | 0.675 |
MASTL |
0.770 | -0.124 | -2 | 0.272 |
QSK |
0.770 | -0.003 | 4 | 0.822 |
TTBK2 |
0.770 | 0.055 | 2 | 0.618 |
JNK3 |
0.770 | 0.067 | 1 | 0.692 |
CDK8 |
0.770 | -0.001 | 1 | 0.694 |
RSK3 |
0.770 | -0.021 | -3 | 0.788 |
LATS2 |
0.770 | -0.044 | -5 | 0.720 |
RIPK1 |
0.769 | -0.019 | 1 | 0.794 |
PAK1 |
0.769 | -0.042 | -2 | 0.229 |
MSK1 |
0.768 | 0.003 | -3 | 0.771 |
CDK18 |
0.768 | 0.046 | 1 | 0.652 |
MAPKAPK3 |
0.768 | -0.046 | -3 | 0.777 |
CAMK2A |
0.767 | 0.004 | 2 | 0.783 |
PKG2 |
0.767 | -0.034 | -2 | 0.181 |
PLK1 |
0.767 | -0.056 | -2 | 0.255 |
AMPKA2 |
0.767 | -0.026 | -3 | 0.816 |
LATS1 |
0.767 | 0.009 | -3 | 0.844 |
ULK1 |
0.767 | -0.136 | -3 | 0.803 |
CDK19 |
0.767 | 0.006 | 1 | 0.659 |
MSK2 |
0.767 | -0.019 | -3 | 0.779 |
MLK3 |
0.767 | -0.024 | 2 | 0.635 |
ANKRD3 |
0.767 | -0.062 | 1 | 0.825 |
MARK3 |
0.767 | -0.002 | 4 | 0.782 |
MLK2 |
0.766 | -0.093 | 2 | 0.715 |
CLK1 |
0.766 | 0.032 | -3 | 0.772 |
CDK5 |
0.766 | 0.038 | 1 | 0.727 |
AKT2 |
0.766 | 0.028 | -3 | 0.730 |
P38B |
0.765 | 0.037 | 1 | 0.673 |
CDK7 |
0.765 | 0.003 | 1 | 0.711 |
ATM |
0.765 | -0.014 | 1 | 0.710 |
QIK |
0.765 | -0.059 | -3 | 0.832 |
IRE1 |
0.764 | -0.047 | 1 | 0.779 |
NIM1 |
0.764 | -0.076 | 3 | 0.777 |
MPSK1 |
0.764 | 0.135 | 1 | 0.782 |
PKR |
0.764 | -0.020 | 1 | 0.827 |
TSSK2 |
0.764 | -0.097 | -5 | 0.813 |
YSK4 |
0.763 | -0.059 | 1 | 0.764 |
P38A |
0.763 | 0.015 | 1 | 0.736 |
MEKK3 |
0.763 | 0.114 | 1 | 0.785 |
TSSK1 |
0.763 | -0.066 | -3 | 0.854 |
SIK |
0.762 | -0.021 | -3 | 0.769 |
ERK1 |
0.762 | 0.032 | 1 | 0.662 |
WNK3 |
0.762 | -0.168 | 1 | 0.789 |
NEK9 |
0.762 | -0.156 | 2 | 0.725 |
PKACA |
0.762 | -0.007 | -2 | 0.158 |
PKCG |
0.762 | -0.029 | 2 | 0.634 |
CK1A2 |
0.762 | 0.132 | -3 | 0.563 |
MEK1 |
0.761 | -0.080 | 2 | 0.763 |
PAK3 |
0.761 | -0.088 | -2 | 0.215 |
PASK |
0.761 | 0.111 | -3 | 0.867 |
PKCB |
0.761 | -0.017 | 2 | 0.624 |
CDK17 |
0.761 | 0.038 | 1 | 0.607 |
PRP4 |
0.761 | 0.031 | -3 | 0.765 |
DYRK1A |
0.760 | 0.028 | 1 | 0.762 |
P38G |
0.760 | 0.041 | 1 | 0.602 |
DYRK1B |
0.760 | 0.037 | 1 | 0.700 |
CDK13 |
0.760 | -0.002 | 1 | 0.687 |
BRSK1 |
0.760 | -0.024 | -3 | 0.790 |
PAK6 |
0.760 | -0.059 | -2 | 0.172 |
CAMK4 |
0.760 | -0.088 | -3 | 0.815 |
PKCA |
0.760 | -0.031 | 2 | 0.614 |
DYRK3 |
0.760 | 0.034 | 1 | 0.761 |
CDK3 |
0.760 | 0.060 | 1 | 0.625 |
MNK2 |
0.760 | -0.072 | -2 | 0.198 |
PIM2 |
0.759 | 0.008 | -3 | 0.774 |
MARK2 |
0.759 | -0.030 | 4 | 0.749 |
PAK2 |
0.759 | -0.076 | -2 | 0.227 |
MLK4 |
0.759 | -0.038 | 2 | 0.613 |
MAK |
0.759 | 0.065 | -2 | 0.218 |
CDK2 |
0.759 | 0.024 | 1 | 0.759 |
DRAK1 |
0.758 | 0.007 | 1 | 0.786 |
PRKD3 |
0.758 | -0.031 | -3 | 0.765 |
MARK1 |
0.758 | -0.028 | 4 | 0.801 |
VRK2 |
0.757 | -0.138 | 1 | 0.849 |
MST3 |
0.757 | 0.056 | 2 | 0.748 |
MELK |
0.757 | -0.072 | -3 | 0.800 |
TLK2 |
0.757 | -0.062 | 1 | 0.753 |
CK2A2 |
0.757 | 0.084 | 1 | 0.767 |
HIPK3 |
0.757 | 0.031 | 1 | 0.741 |
SGK3 |
0.757 | -0.010 | -3 | 0.777 |
PKCZ |
0.756 | -0.055 | 2 | 0.662 |
MNK1 |
0.756 | -0.062 | -2 | 0.213 |
CAMK1G |
0.756 | -0.006 | -3 | 0.783 |
PLK3 |
0.756 | -0.070 | 2 | 0.747 |
NUAK1 |
0.756 | -0.067 | -3 | 0.791 |
GAK |
0.755 | 0.138 | 1 | 0.843 |
CDK14 |
0.755 | 0.034 | 1 | 0.694 |
CK1G1 |
0.755 | 0.085 | -3 | 0.593 |
BRAF |
0.755 | -0.028 | -4 | 0.825 |
P38D |
0.754 | 0.029 | 1 | 0.597 |
ERK2 |
0.754 | 0.012 | 1 | 0.707 |
CDK12 |
0.753 | 0.000 | 1 | 0.661 |
PERK |
0.753 | -0.045 | -2 | 0.321 |
DNAPK |
0.753 | -0.029 | 1 | 0.654 |
BRSK2 |
0.753 | -0.072 | -3 | 0.804 |
CDK10 |
0.752 | 0.040 | 1 | 0.680 |
PKCH |
0.751 | -0.060 | 2 | 0.603 |
SMG1 |
0.751 | -0.088 | 1 | 0.722 |
TAO3 |
0.751 | 0.009 | 1 | 0.783 |
CHAK1 |
0.751 | -0.114 | 2 | 0.656 |
IRE2 |
0.751 | -0.101 | 2 | 0.639 |
JNK1 |
0.751 | 0.054 | 1 | 0.659 |
CK2A1 |
0.750 | 0.080 | 1 | 0.752 |
MEK5 |
0.750 | -0.087 | 2 | 0.730 |
TLK1 |
0.750 | -0.014 | -2 | 0.345 |
SMMLCK |
0.750 | -0.034 | -3 | 0.832 |
PINK1 |
0.750 | -0.116 | 1 | 0.831 |
MEKK2 |
0.750 | -0.018 | 2 | 0.699 |
CDK9 |
0.749 | -0.018 | 1 | 0.694 |
PLK4 |
0.749 | -0.080 | 2 | 0.555 |
CDK16 |
0.749 | 0.028 | 1 | 0.620 |
ZAK |
0.749 | -0.063 | 1 | 0.762 |
AKT1 |
0.749 | -0.007 | -3 | 0.737 |
DCAMKL1 |
0.748 | -0.050 | -3 | 0.785 |
PHKG1 |
0.748 | -0.095 | -3 | 0.820 |
GCK |
0.747 | 0.077 | 1 | 0.800 |
SNRK |
0.747 | -0.129 | 2 | 0.597 |
NEK2 |
0.747 | -0.154 | 2 | 0.690 |
DAPK3 |
0.746 | -0.005 | -3 | 0.811 |
GSK3A |
0.746 | 0.026 | 4 | 0.457 |
DAPK1 |
0.746 | 0.012 | -3 | 0.805 |
CAMKK1 |
0.745 | -0.100 | -2 | 0.245 |
CHK1 |
0.745 | -0.129 | -3 | 0.794 |
MEKK1 |
0.744 | -0.111 | 1 | 0.771 |
PAK5 |
0.744 | -0.076 | -2 | 0.164 |
MAPKAPK5 |
0.744 | -0.089 | -3 | 0.746 |
SSTK |
0.743 | -0.078 | 4 | 0.817 |
TAK1 |
0.743 | 0.078 | 1 | 0.796 |
NEK5 |
0.743 | -0.103 | 1 | 0.790 |
GSK3B |
0.743 | 0.000 | 4 | 0.450 |
HRI |
0.743 | -0.155 | -2 | 0.276 |
MOK |
0.743 | 0.045 | 1 | 0.771 |
AKT3 |
0.743 | 0.011 | -3 | 0.678 |
NEK11 |
0.742 | -0.009 | 1 | 0.777 |
MST2 |
0.742 | -0.006 | 1 | 0.786 |
WNK4 |
0.742 | -0.117 | -2 | 0.260 |
HPK1 |
0.742 | 0.045 | 1 | 0.789 |
P70S6K |
0.741 | -0.038 | -3 | 0.738 |
LKB1 |
0.741 | -0.039 | -3 | 0.813 |
TTBK1 |
0.741 | -0.039 | 2 | 0.556 |
PKCT |
0.741 | -0.069 | 2 | 0.610 |
PKCE |
0.741 | -0.019 | 2 | 0.613 |
SGK1 |
0.740 | 0.021 | -3 | 0.660 |
CAMKK2 |
0.740 | -0.116 | -2 | 0.228 |
CK1A |
0.740 | 0.151 | -3 | 0.474 |
PAK4 |
0.740 | -0.072 | -2 | 0.169 |
NEK8 |
0.740 | -0.080 | 2 | 0.712 |
CAMK1D |
0.740 | -0.028 | -3 | 0.703 |
IRAK4 |
0.739 | -0.116 | 1 | 0.771 |
PKCI |
0.739 | -0.076 | 2 | 0.623 |
MINK |
0.737 | -0.003 | 1 | 0.777 |
PLK2 |
0.737 | -0.008 | -3 | 0.760 |
DCAMKL2 |
0.737 | -0.077 | -3 | 0.806 |
PDK1 |
0.736 | -0.059 | 1 | 0.774 |
ERK7 |
0.736 | -0.029 | 2 | 0.433 |
TAO2 |
0.736 | -0.091 | 2 | 0.745 |
ROCK2 |
0.736 | -0.000 | -3 | 0.793 |
TNIK |
0.735 | -0.012 | 3 | 0.863 |
MRCKB |
0.735 | -0.017 | -3 | 0.754 |
CDK6 |
0.735 | 0.007 | 1 | 0.668 |
MRCKA |
0.734 | -0.025 | -3 | 0.767 |
EEF2K |
0.734 | -0.036 | 3 | 0.830 |
KHS2 |
0.733 | 0.034 | 1 | 0.790 |
SLK |
0.732 | -0.068 | -2 | 0.221 |
LRRK2 |
0.732 | -0.095 | 2 | 0.744 |
DMPK1 |
0.731 | 0.009 | -3 | 0.780 |
HGK |
0.731 | -0.070 | 3 | 0.855 |
MAP3K15 |
0.731 | -0.055 | 1 | 0.744 |
CDK4 |
0.731 | -0.004 | 1 | 0.651 |
CHK2 |
0.730 | -0.006 | -3 | 0.677 |
PDHK3_TYR |
0.730 | 0.091 | 4 | 0.880 |
MST1 |
0.730 | -0.046 | 1 | 0.773 |
KHS1 |
0.729 | -0.010 | 1 | 0.770 |
NEK4 |
0.729 | -0.124 | 1 | 0.763 |
IRAK1 |
0.729 | -0.176 | -1 | 0.702 |
STK33 |
0.729 | -0.081 | 2 | 0.563 |
MEKK6 |
0.729 | -0.085 | 1 | 0.769 |
PHKG2 |
0.728 | -0.134 | -3 | 0.795 |
VRK1 |
0.728 | -0.092 | 2 | 0.756 |
BUB1 |
0.728 | -0.029 | -5 | 0.780 |
BMPR2_TYR |
0.727 | 0.153 | -1 | 0.859 |
PDHK4_TYR |
0.727 | 0.138 | 2 | 0.839 |
LOK |
0.727 | -0.106 | -2 | 0.204 |
CAMK1A |
0.727 | -0.029 | -3 | 0.687 |
PKG1 |
0.726 | -0.064 | -2 | 0.140 |
PBK |
0.726 | -0.023 | 1 | 0.755 |
SBK |
0.725 | 0.005 | -3 | 0.623 |
MAP2K6_TYR |
0.725 | 0.108 | -1 | 0.833 |
PKN1 |
0.724 | -0.059 | -3 | 0.752 |
OSR1 |
0.724 | -0.012 | 2 | 0.698 |
TTK |
0.723 | -0.015 | -2 | 0.304 |
NEK1 |
0.723 | -0.138 | 1 | 0.773 |
PDHK1_TYR |
0.722 | 0.108 | -1 | 0.845 |
ROCK1 |
0.722 | -0.019 | -3 | 0.763 |
MAP2K4_TYR |
0.721 | 0.020 | -1 | 0.824 |
YANK3 |
0.720 | -0.013 | 2 | 0.413 |
TESK1_TYR |
0.720 | -0.016 | 3 | 0.868 |
HASPIN |
0.719 | -0.003 | -1 | 0.634 |
CRIK |
0.718 | 0.001 | -3 | 0.744 |
YSK1 |
0.718 | -0.108 | 2 | 0.692 |
MEK2 |
0.717 | -0.207 | 2 | 0.708 |
ALPHAK3 |
0.717 | 0.048 | -1 | 0.731 |
RIPK2 |
0.717 | -0.171 | 1 | 0.706 |
TXK |
0.717 | 0.132 | 1 | 0.835 |
PKMYT1_TYR |
0.716 | -0.032 | 3 | 0.839 |
EPHA6 |
0.716 | 0.058 | -1 | 0.851 |
MAP2K7_TYR |
0.714 | -0.122 | 2 | 0.790 |
CK1G2 |
0.713 | 0.166 | -3 | 0.514 |
PINK1_TYR |
0.711 | -0.116 | 1 | 0.829 |
LCK |
0.711 | 0.103 | -1 | 0.835 |
MYO3B |
0.710 | -0.077 | 2 | 0.708 |
BIKE |
0.710 | -0.025 | 1 | 0.725 |
LIMK2_TYR |
0.710 | -0.081 | -3 | 0.863 |
MYO3A |
0.709 | -0.067 | 1 | 0.774 |
EPHB4 |
0.709 | 0.004 | -1 | 0.805 |
BLK |
0.708 | 0.117 | -1 | 0.830 |
FGR |
0.708 | 0.043 | 1 | 0.819 |
FYN |
0.708 | 0.144 | -1 | 0.826 |
NEK3 |
0.707 | -0.186 | 1 | 0.721 |
EPHA4 |
0.707 | 0.036 | 2 | 0.771 |
CK1G3 |
0.707 | 0.103 | -3 | 0.428 |
SYK |
0.707 | 0.232 | -1 | 0.788 |
PTK2 |
0.706 | 0.157 | -1 | 0.821 |
ASK1 |
0.706 | -0.116 | 1 | 0.735 |
SRMS |
0.706 | 0.046 | 1 | 0.829 |
ABL2 |
0.705 | -0.004 | -1 | 0.765 |
HCK |
0.705 | 0.031 | -1 | 0.819 |
YES1 |
0.704 | -0.000 | -1 | 0.807 |
MST1R |
0.704 | -0.067 | 3 | 0.796 |
CSF1R |
0.703 | -0.040 | 3 | 0.779 |
RET |
0.703 | -0.125 | 1 | 0.777 |
ITK |
0.703 | 0.029 | -1 | 0.779 |
FER |
0.701 | -0.029 | 1 | 0.836 |
TAO1 |
0.701 | -0.126 | 1 | 0.702 |
TYRO3 |
0.701 | -0.104 | 3 | 0.789 |
INSRR |
0.700 | -0.010 | 3 | 0.724 |
JAK3 |
0.700 | -0.043 | 1 | 0.758 |
MET |
0.700 | 0.067 | 3 | 0.765 |
LIMK1_TYR |
0.700 | -0.189 | 2 | 0.753 |
ABL1 |
0.700 | -0.026 | -1 | 0.758 |
KIT |
0.699 | -0.019 | 3 | 0.778 |
TYK2 |
0.699 | -0.169 | 1 | 0.769 |
ROS1 |
0.699 | -0.106 | 3 | 0.759 |
EPHB2 |
0.698 | 0.008 | -1 | 0.789 |
BMX |
0.698 | 0.026 | -1 | 0.700 |
JAK2 |
0.698 | -0.136 | 1 | 0.765 |
EPHB1 |
0.697 | -0.035 | 1 | 0.812 |
EPHB3 |
0.697 | -0.032 | -1 | 0.796 |
STLK3 |
0.697 | -0.124 | 1 | 0.719 |
TNK2 |
0.696 | -0.036 | 3 | 0.736 |
DDR1 |
0.696 | -0.154 | 4 | 0.798 |
KDR |
0.695 | -0.038 | 3 | 0.732 |
FLT1 |
0.695 | 0.014 | -1 | 0.811 |
FGFR2 |
0.693 | -0.077 | 3 | 0.763 |
SRC |
0.693 | 0.070 | -1 | 0.804 |
AAK1 |
0.693 | -0.010 | 1 | 0.628 |
FLT3 |
0.692 | -0.091 | 3 | 0.779 |
WEE1_TYR |
0.692 | -0.035 | -1 | 0.705 |
LYN |
0.692 | 0.016 | 3 | 0.705 |
MERTK |
0.692 | -0.050 | 3 | 0.748 |
ERBB2 |
0.692 | 0.002 | 1 | 0.750 |
YANK2 |
0.691 | -0.021 | 2 | 0.421 |
TEC |
0.691 | -0.008 | -1 | 0.701 |
EPHA7 |
0.691 | -0.018 | 2 | 0.748 |
TEK |
0.690 | -0.093 | 3 | 0.714 |
FRK |
0.690 | 0.002 | -1 | 0.816 |
EPHA3 |
0.690 | -0.035 | 2 | 0.731 |
BTK |
0.688 | -0.086 | -1 | 0.732 |
EPHA8 |
0.688 | 0.019 | -1 | 0.804 |
FGFR3 |
0.688 | -0.034 | 3 | 0.734 |
PDGFRB |
0.687 | -0.147 | 3 | 0.789 |
ZAP70 |
0.687 | 0.146 | -1 | 0.709 |
EPHA5 |
0.687 | 0.007 | 2 | 0.752 |
PTK2B |
0.687 | 0.003 | -1 | 0.740 |
JAK1 |
0.687 | -0.095 | 1 | 0.715 |
NEK10_TYR |
0.687 | -0.130 | 1 | 0.674 |
AXL |
0.686 | -0.115 | 3 | 0.751 |
FGFR1 |
0.685 | -0.127 | 3 | 0.741 |
EGFR |
0.685 | 0.002 | 1 | 0.657 |
MATK |
0.684 | -0.038 | -1 | 0.685 |
TNNI3K_TYR |
0.683 | -0.112 | 1 | 0.763 |
PTK6 |
0.683 | -0.136 | -1 | 0.697 |
ERBB4 |
0.683 | 0.074 | 1 | 0.682 |
TNK1 |
0.682 | -0.165 | 3 | 0.769 |
ALK |
0.681 | -0.123 | 3 | 0.701 |
EPHA1 |
0.681 | -0.102 | 3 | 0.737 |
NTRK1 |
0.680 | -0.135 | -1 | 0.767 |
DDR2 |
0.680 | -0.081 | 3 | 0.710 |
LTK |
0.680 | -0.129 | 3 | 0.722 |
FGFR4 |
0.679 | -0.031 | -1 | 0.727 |
PDGFRA |
0.678 | -0.204 | 3 | 0.793 |
INSR |
0.678 | -0.103 | 3 | 0.708 |
EPHA2 |
0.678 | -0.006 | -1 | 0.768 |
FLT4 |
0.678 | -0.111 | 3 | 0.725 |
NTRK3 |
0.676 | -0.093 | -1 | 0.725 |
CSK |
0.675 | -0.097 | 2 | 0.750 |
NTRK2 |
0.673 | -0.166 | 3 | 0.729 |
IGF1R |
0.669 | -0.070 | 3 | 0.645 |
FES |
0.660 | -0.053 | -1 | 0.679 |
MUSK |
0.659 | -0.127 | 1 | 0.646 |