Motif 387 (n=112)

Position-wise Probabilities
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uniprot genes site source protein function
A0A087WTJ2 GIMAP1-GIMAP5 S424 ochoa GIMAP1-GIMAP5 readthrough None
A0A0C4DFX4 None S3034 ochoa Snf2 related CREBBP activator protein None
A8CG34 POM121C S328 ochoa Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
O00273 DFFA S257 ochoa DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) Inhibitor of the caspase-activated DNase (DFF40).
O14686 KMT2D S3202 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14874 BCKDK S360 ochoa Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4) Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:24449431, PubMed:29779826, PubMed:37558654). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-337, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (PubMed:29779826, PubMed:37558654). Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxxE/D canonical motif (PubMed:29779826). {ECO:0000269|PubMed:24449431, ECO:0000269|PubMed:29779826, ECO:0000269|PubMed:37558654}.
O15055 PER2 S696 psp Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}.
O15355 PPM1G S243 ochoa Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) None
O15503 INSIG1 S43 psp Insulin-induced gene 1 protein (INSIG-1) Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}.
O60299 LZTS3 S647 ochoa Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1) May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. {ECO:0000250|UniProtKB:Q8K1Q4}.
O60361 NME2P1 S110 ochoa Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}.
O75150 RNF40 S528 ochoa E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
O75815 BCAR3 S317 ochoa Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.
O75943 RAD17 S656 psp Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}.
O94972 TRIM37 S808 ochoa E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}.
O94992 HEXIM1 S69 ochoa Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}.
O95071 UBR5 S174 ochoa|psp E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}.
O95674 CDS2 S41 ochoa Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}.
P06127 CD5 S454 ochoa T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}.
P12830 CDH1 S793 ochoa Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}.
P15036 ETS2 S225 psp Protein C-ets-2 Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}.
P15056 BRAF S405 ochoa Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P15336 ATF2 S310 ochoa Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}.
P15531 NME1 S125 ochoa Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}.
P16144 ITGB4 S1084 ochoa Integrin beta-4 (GP150) (CD antigen CD104) Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P16157 ANK1 S960 ochoa Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.
P17600 SYN1 S513 ochoa Synapsin-1 (Brain protein 4.1) (Synapsin I) Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}.
P19838 NFKB1 S80 psp Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}.
P22392 NME2 S125 ochoa Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}.
P22681 CBL S619 ochoa|psp E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}.
P41162 ETV3 S365 ochoa ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}.
P43243 MATR3 S37 ochoa Matrin-3 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}.
P46109 CRKL S184 ochoa Crk-like protein May mediate the transduction of intracellular signals.
P46939 UTRN S2226 ochoa Utrophin (Dystrophin-related protein 1) (DRP-1) May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.
P51116 FXR2 S516 ochoa RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P56524 HDAC4 S467 ochoa|psp Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
P56524 HDAC4 S636 ochoa Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
Q01082 SPTBN1 S2319 ochoa Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}.
Q01860 POU5F1 S93 psp POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}.
Q02086 SP2 S30 ochoa Transcription factor Sp2 Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Q02446 SP4 S43 ochoa Transcription factor Sp4 (SPR-1) Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Q03252 LMNB2 S541 ochoa Lamin-B2 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}.
Q07157 TJP1 S1142 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q12802 AKAP13 S1229 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q13459 MYO9B S1261 ochoa Unconventional myosin-IXb (Unconventional myosin-9b) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.
Q13625 TP53BP2 S361 ochoa|psp Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q14689 DIP2A S154 ochoa Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}.
Q14847 LASP1 S167 ochoa LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.
Q14980 NUMA1 S2096 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q15361 TTF1 S253 ochoa Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}.
Q15772 SPEG S2037 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q16825 PTPN21 S484 ochoa Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) None
Q2TAZ0 ATG2A S1453 ochoa Autophagy-related protein 2 homolog A Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
Q58A45 PAN3 S191 ochoa PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}.
Q5M7Z0 RNFT1 S58 ochoa E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}.
Q5T5P2 KIAA1217 S169 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5TCZ1 SH3PXD2A S800 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5VSL9 STRIP1 S788 ochoa Striatin-interacting protein 1 (Protein FAM40A) Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}.
Q5VYK3 ECPAS S833 ochoa Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}.
Q641Q2 WASHC2A S1091 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q6PJ61 FBXO46 S67 psp F-box only protein 46 (F-box only protein 34-like) Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}.
Q6PJI9 WDR59 S756 ochoa GATOR2 complex protein WDR59 (WD repeat-containing protein 59) As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36577058). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027, ECO:0000269|PubMed:36577058}.
Q6PKG0 LARP1 S584 ochoa La-related protein 1 (La ribonucleoprotein domain family member 1) RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
Q6ZRS2 SRCAP S3211 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q76N89 HECW1 S532 ochoa E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.
Q7KZ85 SUPT6H S1708 ochoa Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}.
Q7Z434 MAVS S419 ochoa Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}.
Q86UY5 FAM83A S113 ochoa Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}.
Q86V48 LUZP1 S839 ochoa Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}.
Q86VQ1 GLCCI1 S277 ochoa Glucocorticoid-induced transcript 1 protein None
Q86YC2 PALB2 S376 ochoa|psp Partner and localizer of BRCA2 Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}.
Q8N5S9 CAMKK1 S475 ochoa|psp Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}.
Q8N612 FHIP1B S901 ochoa FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.
Q8ND25 ZNRF1 S123 ochoa E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998). {ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:28593998, ECO:0000269|PubMed:29626159, ECO:0000269|PubMed:33996800, ECO:0000269|PubMed:37158982, ECO:0000305|PubMed:14561866}.
Q8NEY1 NAV1 S1381 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8TE76 MORC4 S620 ochoa MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4) Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:26933034}.
Q8WU79 SMAP2 S240 ochoa Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}.
Q8WUA7 TBC1D22A S150 ochoa TBC1 domain family member 22A May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}.
Q8WVM7 STAG1 S1142 ochoa Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Q92625 ANKS1A S579 ochoa Ankyrin repeat and SAM domain-containing protein 1A (Odin) Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}.
Q96F15 GIMAP5 S220 ochoa GTPase IMAP family member 5 (Immune-associated nucleotide-binding protein 5) (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3) Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8BWF2, ECO:0000250|UniProtKB:Q8K3L6, ECO:0000269|PubMed:29382851}.
Q96F81 DISP1 S64 ochoa Protein dispatched homolog 1 Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}.
Q96HA1 POM121 S351 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96JT2 SLC45A3 S422 ochoa Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}.
Q96RG2 PASK S119 ochoa PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.
Q96RG2 PASK S956 ochoa|psp PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.
Q96T37 RBM15 S159 ochoa RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
Q99611 SEPHS2 S97 ochoa Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) Synthesizes selenophosphate from selenide and ATP. {ECO:0000250|UniProtKB:P49903}.
Q9BRK4 LZTS2 S227 ochoa Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
Q9BU19 ZNF692 S470 psp Zinc finger protein 692 (AICAR responsive element binding protein) May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}.
Q9BV38 WDR18 S368 ochoa WD repeat-containing protein 18 Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). May play a role during development (By similarity). {ECO:0000250|UniProtKB:Q68EI0, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}.
Q9BX66 SORBS1 S146 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9C0D0 PHACTR1 S190 ochoa Phosphatase and actin regulator 1 Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}.
Q9C0K0 BCL11B S110 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9GZY6 LAT2 S55 ochoa Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}.
Q9H4B6 SAV1 S94 ochoa Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}.
Q9H706 GAREM1 S625 ochoa GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}.
Q9HAU0 PLEKHA5 S596 ochoa Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) None
Q9HCL2 GPAM S604 ochoa Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids (PubMed:18238778, PubMed:19075029, PubMed:36522428). Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid (PubMed:18238778). Has a narrow hydrophobic binding cleft that selects for a linear acyl chain (PubMed:36522428). Catalytic activity is higher for substrates with a 16-carbon acyl chain (PubMed:36522428). {ECO:0000269|PubMed:18238778, ECO:0000269|PubMed:19075029, ECO:0000269|PubMed:36522428}.
Q9HCM4 EPB41L5 S423 ochoa Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}.
Q9P107 GMIP S440 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9UJM3 ERRFI1 S126 ochoa ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
Q9UQL6 HDAC5 S498 ochoa|psp Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.
Q9Y3M8 STARD13 S182 ochoa StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}.
Q9Y6A5 TACC3 S505 ochoa Transforming acidic coiled-coil-containing protein 3 (ERIC-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q9Y6X9 MORC2 S686 ochoa ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}.
Q9NRR5 UBQLN4 S274 Sugiyama Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}.
Q9UMX0 UBQLN1 S264 Sugiyama Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1) Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:19822669). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804). {ECO:0000250|UniProtKB:Q9JJP9, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:22233804, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:23459205, ECO:0000303|PubMed:15147878}.; FUNCTION: [Isoform 1]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}.; FUNCTION: [Isoform 2]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. {ECO:0000269|PubMed:18953672}.; FUNCTION: [Isoform 3]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}.
Q9Y262 EIF3L S416 Sugiyama Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
O60941 DTNB S465 Sugiyama Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}.
Q9Y4J8 DTNA S501 Sugiyama Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
O15037 KHNYN S299 Sugiyama Protein KHNYN (KH and NYN domain-containing protein) None
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reactome_id name p -log10_p
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.000148 3.829
R-HSA-2559585 Oncogene Induced Senescence 0.000328 3.484
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.037477 1.426
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.037477 1.426
R-HSA-8941237 Invadopodia formation 0.037477 1.426
R-HSA-9706377 FLT3 signaling by CBL mutants 0.052075 1.283
R-HSA-176417 Phosphorylation of Emi1 0.059291 1.227
R-HSA-5603029 IkBA variant leads to EDA-ID 0.059291 1.227
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity 0.059291 1.227
R-HSA-9912481 Branched-chain ketoacid dehydrogenase kinase deficiency 0.066453 1.177
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 0.073561 1.133
R-HSA-418886 Netrin mediated repulsion signals 0.073561 1.133
R-HSA-2470946 Cohesin Loading onto Chromatin 0.073561 1.133
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.073561 1.133
R-HSA-446107 Type I hemidesmosome assembly 0.080615 1.094
R-HSA-9660537 Signaling by MRAS-complex mutants 0.080615 1.094
R-HSA-8875656 MET receptor recycling 0.080615 1.094
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.080615 1.094
R-HSA-912631 Regulation of signaling by CBL 0.014791 1.830
R-HSA-8875555 MET activates RAP1 and RAC1 0.094564 1.024
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.094564 1.024
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.019739 1.705
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.101459 0.994
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.101459 0.994
R-HSA-933542 TRAF6 mediated NF-kB activation 0.022437 1.649
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.108302 0.965
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.115094 0.939
R-HSA-445095 Interaction between L1 and Ankyrins 0.026752 1.573
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.029799 1.526
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.031372 1.503
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.032977 1.482
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.032977 1.482
R-HSA-418885 DCC mediated attractive signaling 0.135163 0.869
R-HSA-9027284 Erythropoietin activates RAS 0.135163 0.869
R-HSA-1855170 IPs transport between nucleus and cytosol 0.036281 1.440
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.036281 1.440
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.037979 1.420
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.141751 0.848
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.041465 1.382
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 0.148290 0.829
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.048778 1.312
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.050674 1.295
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.167612 0.776
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.056519 1.248
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.173955 0.760
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.173955 0.760
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.173955 0.760
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.173955 0.760
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.173955 0.760
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.211022 0.676
R-HSA-73863 RNA Polymerase I Transcription Termination 0.223007 0.652
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.022368 1.650
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.060398 1.219
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.060398 1.219
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.005145 2.289
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.095830 1.018
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.151150 0.821
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.092692 1.033
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.092692 1.033
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.128524 0.891
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.092692 1.033
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.018445 1.734
R-HSA-191650 Regulation of gap junction activity 0.044804 1.349
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.011494 1.940
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.125236 0.902
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.127776 0.894
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.083434 1.079
R-HSA-170968 Frs2-mediated activation 0.007683 2.114
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.008571 2.067
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.036281 1.440
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.154780 0.810
R-HSA-418990 Adherens junctions interactions 0.110167 0.958
R-HSA-421270 Cell-cell junction organization 0.154238 0.812
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.135163 0.869
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.217037 0.663
R-HSA-446728 Cell junction organization 0.079141 1.102
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.191701 0.717
R-HSA-140342 Apoptosis induced DNA fragmentation 0.094564 1.024
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.064935 1.188
R-HSA-169893 Prolonged ERK activation events 0.010477 1.980
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.003978 2.400
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.148290 0.829
R-HSA-1500931 Cell-Cell communication 0.044786 1.349
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.145215 0.838
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.044804 1.349
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 0.087616 1.057
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.003978 2.400
R-HSA-350054 Notch-HLH transcription pathway 0.019739 1.705
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.108302 0.965
R-HSA-209560 NF-kB is activated and signals survival 0.108302 0.965
R-HSA-418890 Role of second messengers in netrin-1 signaling 0.115094 0.939
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.028259 1.549
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.029799 1.526
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.029799 1.526
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.135163 0.869
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.039707 1.401
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.045066 1.346
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.161220 0.793
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.020212 1.694
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.062586 1.204
R-HSA-6807878 COPI-mediated anterograde transport 0.197218 0.705
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.017526 1.756
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.036281 1.440
R-HSA-177929 Signaling by EGFR 0.086536 1.063
R-HSA-1295596 Spry regulation of FGF signaling 0.009502 2.022
R-HSA-9754189 Germ layer formation at gastrulation 0.014791 1.830
R-HSA-2028269 Signaling by Hippo 0.012552 1.901
R-HSA-447043 Neurofascin interactions 0.066453 1.177
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.072799 1.138
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.004646 2.333
R-HSA-6807004 Negative regulation of MET activity 0.173955 0.760
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.073561 1.133
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO 0.087616 1.057
R-HSA-450341 Activation of the AP-1 family of transcription factors 0.087616 1.057
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.037979 1.420
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.192700 0.715
R-HSA-187687 Signalling to ERKs 0.041465 1.382
R-HSA-212165 Epigenetic regulation of gene expression 0.123275 0.909
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.002989 2.524
R-HSA-5693538 Homology Directed Repair 0.081067 1.091
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.151150 0.821
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.001779 2.750
R-HSA-376172 DSCAM interactions 0.030095 1.522
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.059291 1.227
R-HSA-187706 Signalling to p38 via RIT and RIN 0.059291 1.227
R-HSA-170984 ARMS-mediated activation 0.087616 1.057
R-HSA-191859 snRNP Assembly 0.093480 1.029
R-HSA-194441 Metabolism of non-coding RNA 0.093480 1.029
R-HSA-168325 Viral Messenger RNA Synthesis 0.098196 1.008
R-HSA-9006335 Signaling by Erythropoietin 0.234811 0.629
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 0.080615 1.094
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.005145 2.289
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.217037 0.663
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.066453 1.177
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.128524 0.891
R-HSA-180746 Nuclear import of Rev protein 0.039707 1.401
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.115203 0.939
R-HSA-450294 MAP kinase activation 0.098196 1.008
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.204961 0.688
R-HSA-9834899 Specification of the neural plate border 0.167612 0.776
R-HSA-448424 Interleukin-17 signaling 0.120193 0.920
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.002753 2.560
R-HSA-447038 NrCAM interactions 0.052075 1.283
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 0.052075 1.283
R-HSA-5660668 CLEC7A/inflammasome pathway 0.059291 1.227
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.080615 1.094
R-HSA-8951936 RUNX3 regulates p14-ARF 0.115094 0.939
R-HSA-9706369 Negative regulation of FLT3 0.141751 0.848
R-HSA-177243 Interactions of Rev with host cellular proteins 0.050674 1.295
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.050674 1.295
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.052597 1.279
R-HSA-429947 Deadenylation of mRNA 0.204961 0.688
R-HSA-9839394 TGFBR3 expression 0.211022 0.676
R-HSA-9609690 HCMV Early Events 0.226979 0.644
R-HSA-6806834 Signaling by MET 0.145882 0.836
R-HSA-5693607 Processing of DNA double-strand break ends 0.148511 0.828
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 0.094564 1.024
R-HSA-9682385 FLT3 signaling in disease 0.043251 1.364
R-HSA-9659379 Sensory processing of sound 0.143263 0.844
R-HSA-176187 Activation of ATR in response to replication stress 0.036281 1.440
R-HSA-9762293 Regulation of CDH11 gene transcription 0.087616 1.057
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.003314 2.480
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.052075 1.283
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 0.059291 1.227
R-HSA-447041 CHL1 interactions 0.073561 1.133
R-HSA-448706 Interleukin-1 processing 0.087616 1.057
R-HSA-193692 Regulated proteolysis of p75NTR 0.087616 1.057
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.135163 0.869
R-HSA-1483148 Synthesis of PG 0.148290 0.829
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.046908 1.329
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.064656 1.189
R-HSA-8943724 Regulation of PTEN gene transcription 0.095830 1.018
R-HSA-5578749 Transcriptional regulation by small RNAs 0.125236 0.902
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.233480 0.632
R-HSA-9909396 Circadian clock 0.104964 0.979
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.056519 1.248
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.161220 0.793
R-HSA-3214841 PKMTs methylate histone lysines 0.052597 1.279
R-HSA-1474165 Reproduction 0.101838 0.992
R-HSA-2559583 Cellular Senescence 0.004431 2.353
R-HSA-5693532 DNA Double-Strand Break Repair 0.143446 0.843
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.202755 0.693
R-HSA-5654743 Signaling by FGFR4 0.058517 1.233
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.034926 1.457
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.202755 0.693
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.202755 0.693
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.121834 0.914
R-HSA-9675151 Disorders of Developmental Biology 0.148290 0.829
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.048778 1.312
R-HSA-5654741 Signaling by FGFR3 0.062586 1.204
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.223007 0.652
R-HSA-75153 Apoptotic execution phase 0.008462 2.073
R-HSA-193639 p75NTR signals via NF-kB 0.135163 0.869
R-HSA-8853884 Transcriptional Regulation by VENTX 0.052597 1.279
R-HSA-2980766 Nuclear Envelope Breakdown 0.088833 1.051
R-HSA-5654738 Signaling by FGFR2 0.145882 0.836
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.225064 0.648
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.003939 2.405
R-HSA-9932451 SWI/SNF chromatin remodelers 0.211022 0.676
R-HSA-9932444 ATP-dependent chromatin remodelers 0.211022 0.676
R-HSA-9705683 SARS-CoV-2-host interactions 0.042303 1.374
R-HSA-9675135 Diseases of DNA repair 0.008462 2.073
R-HSA-5654736 Signaling by FGFR1 0.086536 1.063
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.135163 0.869
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.041465 1.382
R-HSA-75109 Triglyceride biosynthesis 0.223007 0.652
R-HSA-6784531 tRNA processing in the nucleus 0.100580 0.997
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.097221 1.012
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.077539 1.110
R-HSA-3214847 HATs acetylate histones 0.205530 0.687
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.219466 0.659
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.180251 0.744
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.180251 0.744
R-HSA-1433559 Regulation of KIT signaling 0.128524 0.891
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.234811 0.629
R-HSA-9018519 Estrogen-dependent gene expression 0.006637 2.178
R-HSA-8878171 Transcriptional regulation by RUNX1 0.041105 1.386
R-HSA-9758941 Gastrulation 0.039831 1.400
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.025279 1.597
R-HSA-9748787 Azathioprine ADME 0.073159 1.136
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.234811 0.629
R-HSA-9827857 Specification of primordial germ cells 0.012552 1.901
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 0.192700 0.715
R-HSA-9692914 SARS-CoV-1-host interactions 0.062407 1.205
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.121834 0.914
R-HSA-210991 Basigin interactions 0.180251 0.744
R-HSA-74160 Gene expression (Transcription) 0.121385 0.916
R-HSA-1643713 Signaling by EGFR in Cancer 0.217037 0.663
R-HSA-190236 Signaling by FGFR 0.202755 0.693
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.013651 1.865
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.058517 1.233
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 0.023872 1.622
R-HSA-9865118 Diseases of branched-chain amino acid catabolism 0.217037 0.663
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.050485 1.297
R-HSA-68875 Mitotic Prophase 0.083910 1.076
R-HSA-70171 Glycolysis 0.208310 0.681
R-HSA-4839726 Chromatin organization 0.056164 1.251
R-HSA-166520 Signaling by NTRKs 0.134712 0.871
R-HSA-9755088 Ribavirin ADME 0.018445 1.734
R-HSA-69473 G2/M DNA damage checkpoint 0.130329 0.885
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.122708 0.911
R-HSA-193704 p75 NTR receptor-mediated signalling 0.205530 0.687
R-HSA-109581 Apoptosis 0.049934 1.302
R-HSA-9823730 Formation of definitive endoderm 0.015970 1.797
R-HSA-373753 Nephrin family interactions 0.173955 0.760
R-HSA-9006936 Signaling by TGFB family members 0.155981 0.807
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.192700 0.715
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.213881 0.670
R-HSA-3247509 Chromatin modifying enzymes 0.130756 0.884
R-HSA-8939211 ESR-mediated signaling 0.047958 1.319
R-HSA-9823739 Formation of the anterior neural plate 0.135163 0.869
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.192700 0.715
R-HSA-3000170 Syndecan interactions 0.198853 0.701
R-HSA-3000157 Laminin interactions 0.211022 0.676
R-HSA-1169408 ISG15 antiviral mechanism 0.132893 0.876
R-HSA-5357801 Programmed Cell Death 0.094622 1.024
R-HSA-2262752 Cellular responses to stress 0.171007 0.767
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.154780 0.810
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.154780 0.810
R-HSA-844456 The NLRP3 inflammasome 0.167612 0.776
R-HSA-189200 Cellular hexose transport 0.192700 0.715
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.071001 1.149
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.034613 1.461
R-HSA-1059683 Interleukin-6 signaling 0.121834 0.914
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.095830 1.018
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.095830 1.018
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.095830 1.018
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.095830 1.018
R-HSA-9694516 SARS-CoV-2 Infection 0.153056 0.815
R-HSA-212436 Generic Transcription Pathway 0.219823 0.658
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.139930 0.854
R-HSA-1474244 Extracellular matrix organization 0.053203 1.274
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.145215 0.838
R-HSA-9006931 Signaling by Nuclear Receptors 0.170237 0.769
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.164478 0.784
R-HSA-9679506 SARS-CoV Infections 0.152673 0.816
R-HSA-622312 Inflammasomes 0.228931 0.640
R-HSA-9678108 SARS-CoV-1 Infection 0.185818 0.731
R-HSA-6783589 Interleukin-6 family signaling 0.204961 0.688
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.095830 1.018
R-HSA-1980143 Signaling by NOTCH1 0.135469 0.868
R-HSA-211000 Gene Silencing by RNA 0.230672 0.637
R-HSA-5633007 Regulation of TP53 Activity 0.155981 0.807
R-HSA-73857 RNA Polymerase II Transcription 0.235357 0.628
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.236291 0.627
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.239103 0.621
R-HSA-166166 MyD88-independent TLR4 cascade 0.239103 0.621
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.240646 0.619
R-HSA-114452 Activation of BH3-only proteins 0.240646 0.619
R-HSA-1483249 Inositol phosphate metabolism 0.244732 0.611
R-HSA-182971 EGFR downregulation 0.246438 0.608
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.246438 0.608
R-HSA-9833109 Evasion by RSV of host interferon responses 0.246438 0.608
R-HSA-186763 Downstream signal transduction 0.246438 0.608
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.247549 0.606
R-HSA-9675126 Diseases of mitotic cell cycle 0.252185 0.598
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.256006 0.592
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.257889 0.589
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.257889 0.589
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.257889 0.589
R-HSA-373760 L1CAM interactions 0.261647 0.582
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.263549 0.579
R-HSA-5693537 Resolution of D-Loop Structures 0.263549 0.579
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.263549 0.579
R-HSA-70326 Glucose metabolism 0.264468 0.578
R-HSA-8957322 Metabolism of steroids 0.269120 0.570
R-HSA-5673000 RAF activation 0.269167 0.570
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.269167 0.570
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.269167 0.570
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.269167 0.570
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.270112 0.568
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.270112 0.568
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.274743 0.561
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.274743 0.561
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.274743 0.561
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.275754 0.559
R-HSA-3371556 Cellular response to heat stress 0.275754 0.559
R-HSA-8953897 Cellular responses to stimuli 0.277993 0.556
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.278574 0.555
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.278574 0.555
R-HSA-111933 Calmodulin induced events 0.280276 0.552
R-HSA-111997 CaM pathway 0.280276 0.552
R-HSA-8941326 RUNX2 regulates bone development 0.280276 0.552
R-HSA-162909 Host Interactions of HIV factors 0.284214 0.546
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.285767 0.544
R-HSA-933541 TRAF6 mediated IRF7 activation 0.285767 0.544
R-HSA-4641258 Degradation of DVL 0.285767 0.544
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.285767 0.544
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.285767 0.544
R-HSA-5689896 Ovarian tumor domain proteases 0.285767 0.544
R-HSA-8875878 MET promotes cell motility 0.291217 0.536
R-HSA-69481 G2/M Checkpoints 0.295479 0.529
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.296626 0.528
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.296626 0.528
R-HSA-162582 Signal Transduction 0.299364 0.524
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.301993 0.520
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.301993 0.520
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.301993 0.520
R-HSA-5260271 Diseases of Immune System 0.301993 0.520
R-HSA-9607240 FLT3 Signaling 0.307320 0.512
R-HSA-15869 Metabolism of nucleotides 0.311154 0.507
R-HSA-9656223 Signaling by RAF1 mutants 0.312607 0.505
R-HSA-5674135 MAP2K and MAPK activation 0.312607 0.505
R-HSA-9932298 Degradation of CRY and PER proteins 0.312607 0.505
R-HSA-5675221 Negative regulation of MAPK pathway 0.312607 0.505
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.317853 0.498
R-HSA-111996 Ca-dependent events 0.317853 0.498
R-HSA-157118 Signaling by NOTCH 0.319488 0.496
R-HSA-1433557 Signaling by SCF-KIT 0.323060 0.491
R-HSA-1640170 Cell Cycle 0.323105 0.491
R-HSA-373752 Netrin-1 signaling 0.328228 0.484
R-HSA-5683826 Surfactant metabolism 0.328228 0.484
R-HSA-1489509 DAG and IP3 signaling 0.333356 0.477
R-HSA-6807070 PTEN Regulation 0.334663 0.475
R-HSA-9649948 Signaling downstream of RAS mutants 0.338445 0.471
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.338445 0.471
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.338445 0.471
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.338445 0.471
R-HSA-6802949 Signaling by RAS mutants 0.338445 0.471
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.338445 0.471
R-HSA-9839373 Signaling by TGFBR3 0.338445 0.471
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.338445 0.471
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.338445 0.471
R-HSA-9609646 HCMV Infection 0.340331 0.468
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.343496 0.464
R-HSA-162599 Late Phase of HIV Life Cycle 0.345755 0.461
R-HSA-9031628 NGF-stimulated transcription 0.348509 0.458
R-HSA-8856828 Clathrin-mediated endocytosis 0.348519 0.458
R-HSA-9766229 Degradation of CDH1 0.353484 0.452
R-HSA-157858 Gap junction trafficking and regulation 0.353484 0.452
R-HSA-199977 ER to Golgi Anterograde Transport 0.359535 0.444
R-HSA-69242 S Phase 0.362279 0.441
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.362279 0.441
R-HSA-1169091 Activation of NF-kappaB in B cells 0.363321 0.440
R-HSA-70895 Branched-chain amino acid catabolism 0.363321 0.440
R-HSA-9734767 Developmental Cell Lineages 0.367366 0.435
R-HSA-9856651 MITF-M-dependent gene expression 0.367754 0.434
R-HSA-112382 Formation of RNA Pol II elongation complex 0.368183 0.434
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.368183 0.434
R-HSA-6794361 Neurexins and neuroligins 0.368183 0.434
R-HSA-68886 M Phase 0.370504 0.431
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.373009 0.428
R-HSA-1221632 Meiotic synapsis 0.373009 0.428
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.373009 0.428
R-HSA-9639288 Amino acids regulate mTORC1 0.373009 0.428
R-HSA-445355 Smooth Muscle Contraction 0.373009 0.428
R-HSA-9711123 Cellular response to chemical stress 0.377722 0.423
R-HSA-72649 Translation initiation complex formation 0.377798 0.423
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.377798 0.423
R-HSA-73887 Death Receptor Signaling 0.378649 0.422
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.381361 0.419
R-HSA-9012852 Signaling by NOTCH3 0.382551 0.417
R-HSA-9610379 HCMV Late Events 0.386770 0.413
R-HSA-162587 HIV Life Cycle 0.386770 0.413
R-HSA-72702 Ribosomal scanning and start codon recognition 0.387268 0.412
R-HSA-193648 NRAGE signals death through JNK 0.387268 0.412
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.387268 0.412
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.387268 0.412
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.387268 0.412
R-HSA-9711097 Cellular response to starvation 0.389467 0.410
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.389844 0.409
R-HSA-9764561 Regulation of CDH1 Function 0.391949 0.407
R-HSA-1483166 Synthesis of PA 0.391949 0.407
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.396594 0.402
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.396594 0.402
R-HSA-429914 Deadenylation-dependent mRNA decay 0.401205 0.397
R-HSA-8979227 Triglyceride metabolism 0.401205 0.397
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.401205 0.397
R-HSA-352230 Amino acid transport across the plasma membrane 0.401205 0.397
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.406523 0.391
R-HSA-112043 PLC beta mediated events 0.410321 0.387
R-HSA-5619102 SLC transporter disorders 0.413498 0.384
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.414827 0.382
R-HSA-375165 NCAM signaling for neurite out-growth 0.414827 0.382
R-HSA-186797 Signaling by PDGF 0.414827 0.382
R-HSA-9707616 Heme signaling 0.414827 0.382
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.414827 0.382
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.419300 0.377
R-HSA-8848021 Signaling by PTK6 0.419300 0.377
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.423738 0.373
R-HSA-72306 tRNA processing 0.424031 0.373
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.428143 0.368
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.432514 0.364
R-HSA-1483257 Phospholipid metabolism 0.432922 0.364
R-HSA-112040 G-protein mediated events 0.436852 0.360
R-HSA-9958863 SLC-mediated transport of amino acids 0.436852 0.360
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.441157 0.355
R-HSA-168255 Influenza Infection 0.447369 0.349
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.449670 0.347
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.449670 0.347
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.449670 0.347
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.453878 0.343
R-HSA-453276 Regulation of mitotic cell cycle 0.453878 0.343
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.453878 0.343
R-HSA-427413 NoRC negatively regulates rRNA expression 0.453878 0.343
R-HSA-201681 TCF dependent signaling in response to WNT 0.457573 0.340
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.458054 0.339
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.458054 0.339
R-HSA-69052 Switching of origins to a post-replicative state 0.462199 0.335
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.462199 0.335
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.466312 0.331
R-HSA-9013694 Signaling by NOTCH4 0.466312 0.331
R-HSA-69278 Cell Cycle, Mitotic 0.466502 0.331
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.470393 0.328
R-HSA-8852135 Protein ubiquitination 0.470393 0.328
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.474444 0.324
R-HSA-168898 Toll-like Receptor Cascades 0.477655 0.321
R-HSA-73864 RNA Polymerase I Transcription 0.482454 0.317
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.482454 0.317
R-HSA-416482 G alpha (12/13) signalling events 0.482454 0.317
R-HSA-216083 Integrin cell surface interactions 0.482454 0.317
R-HSA-68877 Mitotic Prometaphase 0.482605 0.316
R-HSA-9675108 Nervous system development 0.490039 0.310
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.490342 0.310
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.490342 0.310
R-HSA-9833482 PKR-mediated signaling 0.490342 0.310
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.494242 0.306
R-HSA-948021 Transport to the Golgi and subsequent modification 0.504524 0.297
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.506923 0.295
R-HSA-376176 Signaling by ROBO receptors 0.506923 0.295
R-HSA-1483206 Glycerophospholipid biosynthesis 0.506923 0.295
R-HSA-6802957 Oncogenic MAPK signaling 0.509546 0.293
R-HSA-1500620 Meiosis 0.509546 0.293
R-HSA-6794362 Protein-protein interactions at synapses 0.509546 0.293
R-HSA-3700989 Transcriptional Regulation by TP53 0.510669 0.292
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.517025 0.286
R-HSA-438064 Post NMDA receptor activation events 0.520722 0.283
R-HSA-9006925 Intracellular signaling by second messengers 0.524274 0.280
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.524391 0.280
R-HSA-202424 Downstream TCR signaling 0.531645 0.274
R-HSA-112310 Neurotransmitter release cycle 0.531645 0.274
R-HSA-9730414 MITF-M-regulated melanocyte development 0.532811 0.273
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.534549 0.272
R-HSA-68882 Mitotic Anaphase 0.539711 0.268
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.541995 0.266
R-HSA-9748784 Drug ADME 0.544272 0.264
R-HSA-68867 Assembly of the pre-replicative complex 0.545826 0.263
R-HSA-1474290 Collagen formation 0.549304 0.260
R-HSA-72689 Formation of a pool of free 40S subunits 0.556181 0.255
R-HSA-73894 DNA Repair 0.557123 0.254
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.559581 0.252
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.559581 0.252
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.559581 0.252
R-HSA-8878159 Transcriptional regulation by RUNX3 0.562955 0.250
R-HSA-162906 HIV Infection 0.564410 0.248
R-HSA-9020702 Interleukin-1 signaling 0.576195 0.239
R-HSA-2408557 Selenocysteine synthesis 0.576195 0.239
R-HSA-9842860 Regulation of endogenous retroelements 0.579442 0.237
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.579442 0.237
R-HSA-1483255 PI Metabolism 0.579442 0.237
R-HSA-199991 Membrane Trafficking 0.582646 0.235
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.585863 0.232
R-HSA-111885 Opioid Signalling 0.585863 0.232
R-HSA-9860931 Response of endothelial cells to shear stress 0.585863 0.232
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.589037 0.230
R-HSA-5619507 Activation of HOX genes during differentiation 0.589037 0.230
R-HSA-9833110 RSV-host interactions 0.589037 0.230
R-HSA-69239 Synthesis of DNA 0.598415 0.223
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.598777 0.223
R-HSA-913531 Interferon Signaling 0.598777 0.223
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.601494 0.221
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.601494 0.221
R-HSA-69002 DNA Replication Pre-Initiation 0.604549 0.219
R-HSA-5619115 Disorders of transmembrane transporters 0.606868 0.217
R-HSA-202403 TCR signaling 0.607581 0.216
R-HSA-9855142 Cellular responses to mechanical stimuli 0.619479 0.208
R-HSA-69620 Cell Cycle Checkpoints 0.628864 0.201
R-HSA-72737 Cap-dependent Translation Initiation 0.631020 0.200
R-HSA-72613 Eukaryotic Translation Initiation 0.631020 0.200
R-HSA-422475 Axon guidance 0.631252 0.200
R-HSA-1592230 Mitochondrial biogenesis 0.633850 0.198
R-HSA-8878166 Transcriptional regulation by RUNX2 0.639447 0.194
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.644959 0.190
R-HSA-1266738 Developmental Biology 0.652630 0.185
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.668205 0.175
R-HSA-9658195 Leishmania infection 0.671772 0.173
R-HSA-9824443 Parasitic Infection Pathways 0.671772 0.173
R-HSA-9843745 Adipogenesis 0.676317 0.170
R-HSA-1474228 Degradation of the extracellular matrix 0.678803 0.168
R-HSA-5673001 RAF/MAP kinase cascade 0.685736 0.164
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.693324 0.159
R-HSA-1257604 PIP3 activates AKT signaling 0.695889 0.157
R-HSA-5684996 MAPK1/MAPK3 signaling 0.697555 0.156
R-HSA-1643685 Disease 0.700058 0.155
R-HSA-9664417 Leishmania phagocytosis 0.700339 0.155
R-HSA-9664407 Parasite infection 0.700339 0.155
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.700339 0.155
R-HSA-195721 Signaling by WNT 0.700864 0.154
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.702641 0.153
R-HSA-2871837 FCERI mediated NF-kB activation 0.711677 0.148
R-HSA-112316 Neuronal System 0.724915 0.140
R-HSA-446652 Interleukin-1 family signaling 0.728941 0.137
R-HSA-69306 DNA Replication 0.731026 0.136
R-HSA-449147 Signaling by Interleukins 0.731338 0.136
R-HSA-1989781 PPARA activates gene expression 0.735147 0.134
R-HSA-1280215 Cytokine Signaling in Immune system 0.738265 0.132
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.739206 0.131
R-HSA-112315 Transmission across Chemical Synapses 0.739763 0.131
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.741212 0.130
R-HSA-2467813 Separation of Sister Chromatids 0.752932 0.123
R-HSA-2408522 Selenoamino acid metabolism 0.752932 0.123
R-HSA-5653656 Vesicle-mediated transport 0.764276 0.117
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.765941 0.116
R-HSA-5621481 C-type lectin receptors (CLRs) 0.767743 0.115
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.769532 0.114
R-HSA-5683057 MAPK family signaling cascades 0.772999 0.112
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.773068 0.112
R-HSA-9824446 Viral Infection Pathways 0.781366 0.107
R-HSA-69275 G2/M Transition 0.793181 0.101
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.796357 0.099
R-HSA-453274 Mitotic G2-G2/M phases 0.796357 0.099
R-HSA-389948 Co-inhibition by PD-1 0.814421 0.089
R-HSA-9824439 Bacterial Infection Pathways 0.824462 0.084
R-HSA-425407 SLC-mediated transmembrane transport 0.831619 0.080
R-HSA-397014 Muscle contraction 0.832200 0.080
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.832200 0.080
R-HSA-8951664 Neddylation 0.843508 0.074
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.852923 0.069
R-HSA-5663205 Infectious disease 0.853766 0.069
R-HSA-446203 Asparagine N-linked glycosylation 0.855096 0.068
R-HSA-72312 rRNA processing 0.856307 0.067
R-HSA-202733 Cell surface interactions at the vascular wall 0.861777 0.065
R-HSA-5688426 Deubiquitination 0.879810 0.056
R-HSA-388841 Regulation of T cell activation by CD28 family 0.880741 0.055
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.881547 0.055
R-HSA-6798695 Neutrophil degranulation 0.882998 0.054
R-HSA-8953854 Metabolism of RNA 0.897174 0.047
R-HSA-597592 Post-translational protein modification 0.904924 0.043
R-HSA-1280218 Adaptive Immune System 0.916018 0.038
R-HSA-1852241 Organelle biogenesis and maintenance 0.927549 0.033
R-HSA-556833 Metabolism of lipids 0.948914 0.023
R-HSA-168249 Innate Immune System 0.951014 0.022
R-HSA-71291 Metabolism of amino acids and derivatives 0.958204 0.019
R-HSA-418594 G alpha (i) signalling events 0.963609 0.016
R-HSA-8978868 Fatty acid metabolism 0.963609 0.016
R-HSA-5668914 Diseases of metabolism 0.968898 0.014
R-HSA-72766 Translation 0.969383 0.014
R-HSA-168256 Immune System 0.974167 0.011
R-HSA-392499 Metabolism of proteins 0.984198 0.007
R-HSA-388396 GPCR downstream signalling 0.985413 0.006
R-HSA-372790 Signaling by GPCR 0.991813 0.004
R-HSA-382551 Transport of small molecules 0.996611 0.001
R-HSA-109582 Hemostasis 0.998178 0.001
R-HSA-9709957 Sensory Perception 0.999484 0.000
R-HSA-1430728 Metabolism 0.999770 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.780 0.063 2 0.275
CDC7CDC7 0.779 0.193 1 0.774
FAM20CFAM20C 0.776 0.056 2 0.322
CLK3CLK3 0.775 0.134 1 0.741
HIPK4HIPK4 0.774 0.181 1 0.746
CHAK2CHAK2 0.772 0.243 -1 0.809
PRKD1PRKD1 0.771 0.158 -3 0.697
MOSMOS 0.771 0.142 1 0.781
KISKIS 0.770 0.123 1 0.587
SKMLCKSKMLCK 0.769 0.104 -2 0.841
ATRATR 0.767 0.135 1 0.835
PIM3PIM3 0.767 0.068 -3 0.741
IKKBIKKB 0.766 0.042 -2 0.691
GRK1GRK1 0.766 0.093 -2 0.731
BMPR1BBMPR1B 0.766 0.179 1 0.765
PRKD2PRKD2 0.765 0.132 -3 0.667
CK1ECK1E 0.763 0.193 -3 0.730
RAF1RAF1 0.761 0.033 1 0.772
NDR2NDR2 0.761 -0.003 -3 0.733
PRPKPRPK 0.761 -0.031 -1 0.805
DSTYKDSTYK 0.760 -0.028 2 0.315
IKKAIKKA 0.759 0.048 -2 0.680
CAMK1BCAMK1B 0.759 0.017 -3 0.759
AURCAURC 0.759 0.112 -2 0.671
CDKL5CDKL5 0.759 0.075 -3 0.709
ATMATM 0.758 0.095 1 0.800
GCN2GCN2 0.758 -0.115 2 0.263
MTORMTOR 0.758 -0.000 1 0.692
ERK5ERK5 0.757 0.069 1 0.790
CAMK2GCAMK2G 0.757 -0.066 2 0.335
CDKL1CDKL1 0.757 0.038 -3 0.722
GRK5GRK5 0.756 0.034 -3 0.792
MAPKAPK2MAPKAPK2 0.756 0.067 -3 0.643
SRPK1SRPK1 0.756 0.062 -3 0.681
CK1DCK1D 0.756 0.216 -3 0.694
NEK6NEK6 0.755 0.008 -2 0.773
GRK6GRK6 0.755 0.043 1 0.774
PIM1PIM1 0.755 0.064 -3 0.720
CAMK2BCAMK2B 0.755 0.013 2 0.335
RSK2RSK2 0.755 0.028 -3 0.683
TBK1TBK1 0.754 -0.053 1 0.648
BMPR2BMPR2 0.754 0.003 -2 0.817
GRK7GRK7 0.754 0.117 1 0.707
CK1A2CK1A2 0.753 0.199 -3 0.699
ULK2ULK2 0.753 -0.115 2 0.240
CLK2CLK2 0.753 0.089 -3 0.682
GRK4GRK4 0.752 0.009 -2 0.750
ICKICK 0.752 0.061 -3 0.739
TGFBR1TGFBR1 0.751 0.090 -2 0.781
PDHK4PDHK4 0.751 -0.158 1 0.768
TLK2TLK2 0.751 0.104 1 0.804
MLK1MLK1 0.751 -0.051 2 0.237
PAK1PAK1 0.751 0.031 -2 0.789
CAMK2DCAMK2D 0.751 -0.026 -3 0.714
IKKEIKKE 0.751 -0.051 1 0.643
CK1G1CK1G1 0.751 0.155 -3 0.708
DAPK2DAPK2 0.751 0.057 -3 0.752
AMPKA1AMPKA1 0.751 0.056 -3 0.742
PKACBPKACB 0.751 0.092 -2 0.670
CAMK2ACAMK2A 0.750 0.012 2 0.343
MAPKAPK3MAPKAPK3 0.750 0.038 -3 0.663
CAMLCKCAMLCK 0.750 0.031 -2 0.825
PKACGPKACG 0.750 0.037 -2 0.714
NLKNLK 0.750 -0.036 1 0.727
RIPK3RIPK3 0.750 -0.035 3 0.735
MARK4MARK4 0.750 -0.007 4 0.787
TGFBR2TGFBR2 0.750 0.001 -2 0.747
P90RSKP90RSK 0.750 0.007 -3 0.689
WNK1WNK1 0.750 -0.056 -2 0.843
HIPK2HIPK2 0.749 0.081 1 0.539
PRKXPRKX 0.749 0.107 -3 0.618
NDR1NDR1 0.749 -0.034 -3 0.728
DYRK2DYRK2 0.749 0.024 1 0.638
NEK7NEK7 0.749 -0.075 -3 0.721
MST4MST4 0.748 -0.007 2 0.308
ALK4ALK4 0.748 0.090 -2 0.803
SMG1SMG1 0.748 0.102 1 0.808
RSK3RSK3 0.747 0.008 -3 0.672
NIKNIK 0.747 -0.027 -3 0.764
TSSK2TSSK2 0.747 -0.003 -5 0.787
BMPR1ABMPR1A 0.747 0.135 1 0.731
CLK4CLK4 0.747 0.066 -3 0.702
SRPK2SRPK2 0.747 0.043 -3 0.626
MLK3MLK3 0.747 -0.028 2 0.212
MNK2MNK2 0.746 0.016 -2 0.770
PRKD3PRKD3 0.745 0.064 -3 0.650
LATS2LATS2 0.745 -0.026 -5 0.630
ACVR2BACVR2B 0.745 0.112 -2 0.745
AMPKA2AMPKA2 0.745 0.050 -3 0.715
ULK1ULK1 0.745 -0.143 -3 0.706
PAK3PAK3 0.745 0.004 -2 0.780
MSK1MSK1 0.745 0.036 -3 0.664
DNAPKDNAPK 0.745 0.084 1 0.721
PDHK1PDHK1 0.744 -0.138 1 0.754
MLK2MLK2 0.744 -0.019 2 0.274
RSK4RSK4 0.744 0.024 -3 0.670
ACVR2AACVR2A 0.744 0.084 -2 0.738
PKN3PKN3 0.743 -0.067 -3 0.728
DLKDLK 0.743 -0.048 1 0.774
P70S6KBP70S6KB 0.743 -0.001 -3 0.705
TTBK2TTBK2 0.743 -0.095 2 0.198
NUAK2NUAK2 0.743 -0.032 -3 0.743
NIM1NIM1 0.743 -0.047 3 0.757
TSSK1TSSK1 0.743 0.004 -3 0.747
PKCDPKCD 0.742 -0.023 2 0.236
HUNKHUNK 0.742 -0.132 2 0.250
ALK2ALK2 0.742 0.073 -2 0.778
PKN2PKN2 0.742 -0.056 -3 0.734
RIPK1RIPK1 0.741 -0.081 1 0.775
PAK6PAK6 0.741 0.029 -2 0.721
MSK2MSK2 0.741 -0.002 -3 0.671
CK1ACK1A 0.741 0.200 -3 0.633
IRE1IRE1 0.740 -0.059 1 0.782
AURAAURA 0.740 0.049 -2 0.648
CDK8CDK8 0.740 -0.014 1 0.558
BCKDKBCKDK 0.740 -0.125 -1 0.720
MASTLMASTL 0.739 -0.153 -2 0.743
HIPK1HIPK1 0.739 0.055 1 0.642
PAK2PAK2 0.739 0.004 -2 0.770
MYLK4MYLK4 0.739 0.030 -2 0.766
PKCBPKCB 0.739 -0.033 2 0.192
MLK4MLK4 0.739 -0.040 2 0.182
AURBAURB 0.739 0.059 -2 0.665
CLK1CLK1 0.739 0.047 -3 0.666
QSKQSK 0.739 0.032 4 0.761
SRPK3SRPK3 0.739 0.017 -3 0.673
CHAK1CHAK1 0.739 0.033 2 0.325
NEK9NEK9 0.739 -0.110 2 0.257
CDK19CDK19 0.738 -0.002 1 0.522
GRK2GRK2 0.738 0.026 -2 0.671
BRSK1BRSK1 0.737 -0.041 -3 0.687
CDK7CDK7 0.737 0.014 1 0.565
SIKSIK 0.737 0.021 -3 0.674
ANKRD3ANKRD3 0.736 -0.090 1 0.792
LATS1LATS1 0.736 -0.007 -3 0.720
TLK1TLK1 0.736 0.028 -2 0.767
PKCAPKCA 0.735 -0.034 2 0.202
AKT2AKT2 0.735 0.046 -3 0.630
PKCGPKCG 0.735 -0.054 2 0.202
WNK3WNK3 0.735 -0.205 1 0.763
CAMK4CAMK4 0.734 -0.061 -3 0.722
PKG2PKG2 0.734 0.028 -2 0.666
MNK1MNK1 0.734 -0.014 -2 0.767
PLK1PLK1 0.734 -0.081 -2 0.705
DYRK4DYRK4 0.734 -0.000 1 0.538
PKCZPKCZ 0.734 -0.028 2 0.230
PKRPKR 0.733 -0.040 1 0.802
PHKG1PHKG1 0.733 -0.044 -3 0.720
CDK1CDK1 0.733 0.010 1 0.532
P38BP38B 0.733 0.026 1 0.558
CDK18CDK18 0.733 0.010 1 0.498
GRK3GRK3 0.732 0.045 -2 0.633
MARK3MARK3 0.732 -0.005 4 0.718
MEK1MEK1 0.732 -0.057 2 0.313
P38AP38A 0.731 0.008 1 0.629
JNK2JNK2 0.731 0.001 1 0.509
DYRK1ADYRK1A 0.731 0.021 1 0.633
PKACAPKACA 0.731 0.057 -2 0.633
NEK2NEK2 0.731 -0.067 2 0.274
MELKMELK 0.731 -0.043 -3 0.692
PLK4PLK4 0.730 -0.102 2 0.192
QIKQIK 0.730 -0.070 -3 0.716
BRSK2BRSK2 0.730 -0.072 -3 0.697
DCAMKL1DCAMKL1 0.729 -0.019 -3 0.685
PLK3PLK3 0.729 -0.097 2 0.294
ERK1ERK1 0.729 0.001 1 0.539
MAPKAPK5MAPKAPK5 0.729 -0.035 -3 0.633
VRK2VRK2 0.729 -0.116 1 0.804
DYRK3DYRK3 0.729 0.029 1 0.655
SGK3SGK3 0.729 -0.002 -3 0.665
IRE2IRE2 0.728 -0.093 2 0.195
PKCHPKCH 0.728 -0.080 2 0.180
MARK2MARK2 0.728 -0.032 4 0.690
PRP4PRP4 0.728 0.005 -3 0.674
PASKPASK 0.727 0.002 -3 0.755
MEKK3MEKK3 0.727 -0.062 1 0.752
HIPK3HIPK3 0.727 0.023 1 0.637
YSK4YSK4 0.727 -0.099 1 0.706
JNK3JNK3 0.727 -0.021 1 0.535
SNRKSNRK 0.727 -0.126 2 0.228
MEKK2MEKK2 0.726 -0.025 2 0.239
PIM2PIM2 0.726 0.021 -3 0.668
NUAK1NUAK1 0.726 -0.048 -3 0.691
CHK1CHK1 0.725 -0.027 -3 0.690
P38GP38G 0.725 -0.010 1 0.445
P38DP38D 0.725 0.023 1 0.467
YANK3YANK3 0.725 0.017 2 0.134
PAK4PAK4 0.724 0.021 -2 0.671
LKB1LKB1 0.724 0.131 -3 0.701
MPSK1MPSK1 0.724 0.051 1 0.734
MST3MST3 0.724 0.000 2 0.280
SSTKSSTK 0.724 -0.036 4 0.761
PAK5PAK5 0.724 0.019 -2 0.659
CDK13CDK13 0.724 -0.038 1 0.533
CAMK1GCAMK1G 0.724 -0.043 -3 0.682
NEK5NEK5 0.724 -0.023 1 0.801
PINK1PINK1 0.724 -0.031 1 0.750
PERKPERK 0.724 -0.070 -2 0.766
DYRK1BDYRK1B 0.724 0.005 1 0.558
MAKMAK 0.723 0.091 -2 0.793
BRAFBRAF 0.723 -0.067 -4 0.758
CDK5CDK5 0.723 -0.033 1 0.593
GSK3AGSK3A 0.723 0.033 4 0.502
DRAK1DRAK1 0.722 -0.091 1 0.710
MARK1MARK1 0.722 -0.055 4 0.734
DAPK3DAPK3 0.722 0.052 -3 0.711
DCAMKL2DCAMKL2 0.721 -0.058 -3 0.698
TAO3TAO3 0.721 0.013 1 0.727
CK2A2CK2A2 0.721 0.021 1 0.625
MEK5MEK5 0.721 -0.121 2 0.277
GSK3BGSK3B 0.721 0.019 4 0.496
ERK7ERK7 0.721 -0.040 2 0.138
CDK17CDK17 0.720 -0.021 1 0.444
CAMK1DCAMK1D 0.720 0.003 -3 0.609
WNK4WNK4 0.720 -0.115 -2 0.828
SMMLCKSMMLCK 0.719 -0.017 -3 0.719
AKT1AKT1 0.719 0.025 -3 0.632
PLK2PLK2 0.719 -0.028 -3 0.707
ERK2ERK2 0.719 -0.049 1 0.580
ZAKZAK 0.718 -0.116 1 0.714
DAPK1DAPK1 0.718 0.039 -3 0.709
CDK12CDK12 0.717 -0.040 1 0.507
MEKK1MEKK1 0.717 -0.120 1 0.749
TTBK1TTBK1 0.716 -0.128 2 0.170
BUB1BUB1 0.716 0.142 -5 0.747
PKCTPKCT 0.716 -0.064 2 0.185
IRAK4IRAK4 0.716 -0.101 1 0.783
MOKMOK 0.715 0.071 1 0.716
GAKGAK 0.715 -0.001 1 0.764
CDK14CDK14 0.714 -0.025 1 0.536
CK2A1CK2A1 0.714 0.017 1 0.605
NEK11NEK11 0.714 -0.070 1 0.711
HRIHRI 0.714 -0.149 -2 0.782
CAMKK1CAMKK1 0.713 -0.059 -2 0.689
CDK3CDK3 0.713 -0.009 1 0.464
NEK8NEK8 0.713 -0.090 2 0.256
PKCEPKCE 0.713 -0.032 2 0.196
CAMKK2CAMKK2 0.713 -0.004 -2 0.698
GCKGCK 0.712 0.024 1 0.750
P70S6KP70S6K 0.712 -0.034 -3 0.630
PKCIPKCI 0.712 -0.059 2 0.201
AKT3AKT3 0.712 0.038 -3 0.577
CDK9CDK9 0.711 -0.070 1 0.541
SGK1SGK1 0.710 0.032 -3 0.566
CDK2CDK2 0.710 -0.075 1 0.612
EEF2KEEF2K 0.709 -0.044 3 0.798
STK33STK33 0.709 -0.092 2 0.193
TAK1TAK1 0.709 -0.021 1 0.783
CDK16CDK16 0.709 -0.027 1 0.460
ROCK2ROCK2 0.709 0.044 -3 0.693
CHK2CHK2 0.708 0.010 -3 0.578
JNK1JNK1 0.708 -0.030 1 0.482
TNIKTNIK 0.708 0.013 3 0.842
CDK10CDK10 0.708 -0.027 1 0.522
HPK1HPK1 0.708 0.014 1 0.728
MEKK6MEKK6 0.708 -0.083 1 0.776
CK1G3CK1G3 0.707 0.164 -3 0.595
PHKG2PHKG2 0.707 -0.117 -3 0.693
PDK1PDK1 0.707 -0.056 1 0.692
NEK4NEK4 0.707 -0.048 1 0.757
MRCKBMRCKB 0.707 0.023 -3 0.656
MINKMINK 0.705 -0.005 1 0.744
MAP3K15MAP3K15 0.705 -0.065 1 0.696
MRCKAMRCKA 0.705 0.018 -3 0.666
MST2MST2 0.704 -0.072 1 0.757
HGKHGK 0.704 -0.029 3 0.833
TAO2TAO2 0.704 -0.105 2 0.293
SBKSBK 0.703 0.020 -3 0.527
CAMK1ACAMK1A 0.703 -0.002 -3 0.589
KHS2KHS2 0.702 0.029 1 0.739
IRAK1IRAK1 0.702 -0.208 -1 0.703
NEK1NEK1 0.701 -0.046 1 0.765
PKN1PKN1 0.700 -0.058 -3 0.637
PBKPBK 0.700 0.026 1 0.698
KHS1KHS1 0.700 0.006 1 0.726
LOKLOK 0.700 -0.035 -2 0.700
LRRK2LRRK2 0.699 -0.114 2 0.297
TTKTTK 0.699 0.031 -2 0.739
SLKSLK 0.698 -0.032 -2 0.643
OSR1OSR1 0.698 -0.004 2 0.253
VRK1VRK1 0.696 -0.144 2 0.247
CRIKCRIK 0.696 0.042 -3 0.630
PKG1PKG1 0.696 -0.005 -2 0.592
ALPHAK3ALPHAK3 0.696 0.031 -1 0.745
DMPK1DMPK1 0.695 0.026 -3 0.679
YANK2YANK2 0.695 0.013 2 0.138
PDHK3_TYRPDHK3_TYR 0.694 0.125 4 0.859
MAP2K6_TYRMAP2K6_TYR 0.693 0.113 -1 0.832
ROCK1ROCK1 0.693 0.013 -3 0.669
MST1MST1 0.692 -0.094 1 0.739
PDHK4_TYRPDHK4_TYR 0.691 0.102 2 0.363
YSK1YSK1 0.691 -0.103 2 0.248
MAP2K4_TYRMAP2K4_TYR 0.691 0.154 -1 0.822
PDHK1_TYRPDHK1_TYR 0.689 0.100 -1 0.836
MEK2MEK2 0.689 -0.172 2 0.285
CK1G2CK1G2 0.688 0.125 -3 0.658
CDK6CDK6 0.688 -0.066 1 0.511
CDK4CDK4 0.687 -0.064 1 0.495
MYO3BMYO3B 0.687 -0.022 2 0.295
HASPINHASPIN 0.686 -0.032 -1 0.672
ABL2ABL2 0.685 0.110 -1 0.772
BMPR2_TYRBMPR2_TYR 0.685 0.014 -1 0.826
TESK1_TYRTESK1_TYR 0.684 0.013 3 0.861
RIPK2RIPK2 0.684 -0.223 1 0.658
NEK3NEK3 0.683 -0.119 1 0.706
MAP2K7_TYRMAP2K7_TYR 0.682 -0.094 2 0.335
EPHB4EPHB4 0.681 0.024 -1 0.757
EPHA6EPHA6 0.681 -0.011 -1 0.798
LIMK2_TYRLIMK2_TYR 0.681 0.060 -3 0.743
ABL1ABL1 0.681 0.083 -1 0.763
TXKTXK 0.679 0.070 1 0.790
PKMYT1_TYRPKMYT1_TYR 0.679 -0.026 3 0.830
ASK1ASK1 0.678 -0.134 1 0.669
MYO3AMYO3A 0.678 -0.063 1 0.739
RETRET 0.677 -0.024 1 0.750
TNK2TNK2 0.676 0.071 3 0.745
FGRFGR 0.675 0.025 1 0.825
PINK1_TYRPINK1_TYR 0.675 -0.136 1 0.764
BIKEBIKE 0.675 -0.042 1 0.637
EPHA4EPHA4 0.674 -0.039 2 0.316
FERFER 0.674 -0.002 1 0.830
BLKBLK 0.674 0.083 -1 0.777
SRMSSRMS 0.673 -0.025 1 0.813
ROS1ROS1 0.672 -0.022 3 0.754
CSF1RCSF1R 0.672 -0.025 3 0.779
TAO1TAO1 0.672 -0.112 1 0.657
STLK3STLK3 0.671 -0.116 1 0.692
TYRO3TYRO3 0.671 -0.066 3 0.776
MERTKMERTK 0.671 -0.003 3 0.772
LCKLCK 0.671 0.072 -1 0.772
INSRRINSRR 0.670 -0.022 3 0.729
JAK2JAK2 0.670 -0.027 1 0.735
EPHB1EPHB1 0.670 -0.019 1 0.813
EPHB3EPHB3 0.669 -0.022 -1 0.738
MST1RMST1R 0.669 -0.072 3 0.794
TYK2TYK2 0.669 -0.066 1 0.745
JAK3JAK3 0.668 -0.038 1 0.718
YES1YES1 0.668 -0.043 -1 0.768
BMXBMX 0.668 0.004 -1 0.676
METMET 0.668 0.012 3 0.771
EPHB2EPHB2 0.668 -0.028 -1 0.737
LIMK1_TYRLIMK1_TYR 0.668 -0.137 2 0.320
HCKHCK 0.668 -0.007 -1 0.767
ITKITK 0.667 -0.043 -1 0.740
PTK2PTK2 0.667 0.027 -1 0.740
DDR1DDR1 0.666 -0.123 4 0.814
KITKIT 0.666 -0.030 3 0.773
FGFR2FGFR2 0.665 -0.101 3 0.780
FYNFYN 0.665 0.010 -1 0.737
KDRKDR 0.664 -0.048 3 0.755
EPHA7EPHA7 0.663 -0.048 2 0.299
AXLAXL 0.662 -0.057 3 0.764
SYKSYK 0.661 0.044 -1 0.735
PDGFRBPDGFRB 0.661 -0.104 3 0.782
TNK1TNK1 0.661 -0.043 3 0.762
PTK6PTK6 0.661 -0.046 -1 0.670
FLT1FLT1 0.660 -0.042 -1 0.786
EPHA3EPHA3 0.660 -0.088 2 0.295
NEK10_TYRNEK10_TYR 0.660 -0.007 1 0.605
TNNI3K_TYRTNNI3K_TYR 0.660 -0.026 1 0.781
JAK1JAK1 0.659 0.021 1 0.673
EPHA5EPHA5 0.659 -0.056 2 0.305
LTKLTK 0.659 -0.061 3 0.726
FLT3FLT3 0.659 -0.102 3 0.774
MATKMATK 0.658 -0.032 -1 0.710
AAK1AAK1 0.657 -0.019 1 0.542
FGFR3FGFR3 0.657 -0.090 3 0.754
EPHA8EPHA8 0.657 -0.039 -1 0.735
TECTEC 0.657 -0.062 -1 0.664
PTK2BPTK2B 0.657 -0.042 -1 0.698
ERBB2ERBB2 0.656 -0.079 1 0.687
FGFR1FGFR1 0.656 -0.117 3 0.752
FRKFRK 0.656 -0.062 -1 0.784
ALKALK 0.656 -0.058 3 0.694
EPHA1EPHA1 0.655 -0.080 3 0.757
CSKCSK 0.655 -0.071 2 0.295
FGFR4FGFR4 0.655 -0.035 -1 0.720
NTRK1NTRK1 0.654 -0.110 -1 0.741
TEKTEK 0.654 -0.141 3 0.712
EGFREGFR 0.653 -0.052 1 0.599
LYNLYN 0.653 -0.039 3 0.688
BTKBTK 0.653 -0.135 -1 0.704
NTRK3NTRK3 0.652 -0.044 -1 0.699
INSRINSR 0.652 -0.085 3 0.704
DDR2DDR2 0.652 -0.056 3 0.716
SRCSRC 0.651 -0.044 -1 0.732
EPHA2EPHA2 0.651 -0.051 -1 0.716
PDGFRAPDGFRA 0.651 -0.143 3 0.777
ZAP70ZAP70 0.650 0.059 -1 0.677
WEE1_TYRWEE1_TYR 0.649 -0.092 -1 0.684
ERBB4ERBB4 0.648 -0.015 1 0.629
FLT4FLT4 0.648 -0.141 3 0.743
NTRK2NTRK2 0.645 -0.135 3 0.729
IGF1RIGF1R 0.642 -0.080 3 0.637
FESFES 0.631 -0.071 -1 0.642
MUSKMUSK 0.625 -0.134 1 0.604