Motif 386 (n=183)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0FGR8 | ESYT2 | S704 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| A1L170 | C1orf226 | S30 | ochoa | Uncharacterized protein C1orf226 | None |
| A4FU49 | SH3D21 | S329 | ochoa | SH3 domain-containing protein 21 | None |
| E9PAV3 | NACA | S738 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00444 | PLK4 | S817 | ochoa | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| O14640 | DVL1 | S115 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O15027 | SEC16A | S1174 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15049 | N4BP3 | S130 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15417 | TNRC18 | S1956 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15417 | TNRC18 | S2368 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15530 | PDPK1 | S36 | ochoa | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
| O43149 | ZZEF1 | S1520 | ochoa | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}. |
| O43684 | BUB3 | S135 | psp | Mitotic checkpoint protein BUB3 | Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}. |
| O43815 | STRN | S378 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O43847 | NRDC | S61 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60784 | TOM1 | S473 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75064 | DENND4B | S735 | ochoa | DENN domain-containing protein 4B | Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| O75128 | COBL | S793 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75128 | COBL | S916 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75864 | PPP1R37 | S550 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O76039 | CDKL5 | S388 | ochoa | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) | Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}. |
| O94776 | MTA2 | S352 | ochoa | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| O94979 | SEC31A | S1101 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95466 | FMNL1 | S1031 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95625 | ZBTB11 | S449 | ochoa | Zinc finger and BTB domain-containing protein 11 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P06127 | CD5 | S454 | ochoa | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
| P06748 | NPM1 | S106 | ochoa|psp | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P08559 | PDHA1 | S295 | ochoa|psp | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}. |
| P10636 | MAPT | S427 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P12270 | TPR | S652 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P15976 | GATA1 | S26 | psp | Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) | Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}. |
| P19838 | NFKB1 | S80 | psp | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}. |
| P21860 | ERBB3 | S982 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P27694 | RPA1 | S140 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P27708 | CAD | S1823 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P27816 | MAP4 | S853 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27816 | MAP4 | S896 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27816 | MAP4 | S928 | ochoa|psp | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29803 | PDHA2 | S293 | ochoa | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II) | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:16436377}. |
| P35568 | IRS1 | S766 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P40818 | USP8 | S691 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P41225 | SOX3 | S379 | ochoa | Transcription factor SOX-3 | Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:21183788}. |
| P43146 | DCC | Y1363 | psp | Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}. |
| P46109 | CRKL | S184 | ochoa | Crk-like protein | May mediate the transduction of intracellular signals. |
| P46937 | YAP1 | S149 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P46939 | UTRN | S2226 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P48444 | ARCN1 | S220 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P49189 | ALDH9A1 | S233 | ochoa | 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Formaldehyde dehydrogenase) (EC 1.2.1.46) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed] | Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines. {ECO:0000269|PubMed:10702312, ECO:0000269|PubMed:1799975, ECO:0000269|PubMed:30914451, ECO:0000269|PubMed:8645224}. |
| P49792 | RANBP2 | S1760 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49841 | GSK3B | S389 | ochoa|psp | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:11430833, PubMed:12554650, PubMed:14690523, PubMed:16484495, PubMed:1846781, PubMed:20937854, PubMed:9072970). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282, PubMed:25827072, PubMed:29059170). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (PubMed:21343617). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. |
| P50402 | EMD | S123 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50461 | CSRP3 | S108 | ochoa | Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein) | Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:19752190, ECO:0000269|PubMed:24934443, ECO:0000269|PubMed:27353086}.; FUNCTION: [Isoform 2]: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. {ECO:0000269|PubMed:24860983}. |
| P52735 | VAV2 | S659 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
| P57768 | SNX16 | S108 | ochoa | Sorting nexin-16 | May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}. |
| P85299 | PRR5 | S339 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| P98082 | DAB2 | S264 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01082 | SPTBN1 | S2340 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01167 | FOXK2 | S239 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q01201 | RELB | S472 | psp | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q01826 | SATB1 | S309 | ochoa | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q07687 | DLX2 | S232 | ochoa | Homeobox protein DLX-2 | Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis (By similarity). {ECO:0000250|UniProtKB:P40764}. |
| Q09666 | AHNAK | S5293 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5414 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12770 | SCAP | S483 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
| Q12802 | AKAP13 | S1229 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12955 | ANK3 | S896 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13112 | CHAF1B | S520 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13424 | SNTA1 | S200 | ochoa | Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}. |
| Q13761 | RUNX3 | S251 | ochoa | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q14118 | DAG1 | S807 | ochoa | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] | The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}. |
| Q14738 | PPP2R5D | S62 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q14872 | MTF1 | S620 | psp | Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) | Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). {ECO:0000250|UniProtKB:Q07243, ECO:0000269|PubMed:8065932}. |
| Q15697 | ZNF174 | S173 | ochoa | Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) | Transcriptional repressor. {ECO:0000269|PubMed:7673192}. |
| Q2NKJ3 | CTC1 | S713 | ochoa | CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) | Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Involved in telomere maintenance (PubMed:19854131, PubMed:22863775). Involved in genome stability (PubMed:22863775). May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity). {ECO:0000250|UniProtKB:Q5SUQ9, ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:19854131, ECO:0000269|PubMed:22763445, ECO:0000269|PubMed:22863775, ECO:0000269|PubMed:25483097}. |
| Q2QGD7 | ZXDC | S171 | ochoa | Zinc finger protein ZXDC (ZXD-like zinc finger protein) | Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:17696781}. |
| Q4ADV7 | RIC1 | S1131 | ochoa | Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1) | The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:31932796}. |
| Q4KMP7 | TBC1D10B | S704 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q53GG5 | PDLIM3 | S148 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5JTC6 | AMER1 | S548 | psp | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5M7Z0 | RNFT1 | S58 | ochoa | E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) | E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}. |
| Q5SY16 | NOL9 | S93 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T5P2 | KIAA1217 | S169 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T5X7 | BEND3 | S503 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5T7N3 | KANK4 | S553 | ochoa | KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. {ECO:0000269|PubMed:17996375}. |
| Q5VV41 | ARHGEF16 | S185 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q5VZK9 | CARMIL1 | S1093 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q63ZY3 | KANK2 | S175 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q6DT37 | CDC42BPG | S1475 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6GQQ9 | OTUD7B | S745 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6NUN9 | ZNF746 | S403 | ochoa | Zinc finger protein 746 (Parkin-interacting substrate) (PARIS) | Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:31856708}. |
| Q6PJ61 | FBXO46 | S67 | psp | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
| Q6PL18 | ATAD2 | S1151 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6UN15 | FIP1L1 | S440 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6XZF7 | DNMBP | S458 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZSR9 | None | S157 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q6ZUJ8 | PIK3AP1 | S696 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q7RTP6 | MICAL3 | S1352 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z406 | MYH14 | S595 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z434 | MAVS | S139 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z5J4 | RAI1 | S105 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6I6 | ARHGAP30 | S384 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86TI0 | TBC1D1 | S237 | ochoa|psp | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86V48 | LUZP1 | S905 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VM9 | ZC3H18 | S795 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86WR7 | PROSER2 | S382 | ochoa | Proline and serine-rich protein 2 | None |
| Q86YS7 | C2CD5 | S284 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q86YV5 | PRAG1 | S491 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IUD2 | ERC1 | S109 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IX07 | ZFPM1 | S127 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IY92 | SLX4 | S959 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N556 | AFAP1 | S264 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8NBV4 | PLPP7 | S43 | ochoa | Inactive phospholipid phosphatase 7 (Phosphatidic acid phosphatase type 2 domain-containing protein 3) | Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). {ECO:0000250}. |
| Q8NEY1 | NAV1 | S672 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFH5 | NUP35 | S99 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8TC26 | TMEM163 | S37 | ochoa | Transmembrane protein 163 | Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965). {ECO:0000250|UniProtKB:A9CMA6, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:31697912, ECO:0000269|PubMed:32492420, ECO:0000269|PubMed:35455965, ECO:0000269|PubMed:36204728}. |
| Q8TD19 | NEK9 | S868 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TE67 | EPS8L3 | S444 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
| Q8WU20 | FRS2 | S161 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WUA4 | GTF3C2 | S136 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WWI1 | LMO7 | S926 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWM7 | ATXN2L | S390 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WYP3 | RIN2 | S333 | ochoa | Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2) | Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:11733506}. |
| Q92499 | DDX1 | S436 | ochoa | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q92545 | TMEM131 | S1159 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92560 | BAP1 | S582 | ochoa | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92619 | ARHGAP45 | S951 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92667 | AKAP1 | S69 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92997 | DVL3 | S112 | ochoa | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q969G3 | SMARCE1 | S21 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96D71 | REPS1 | S403 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96PE2 | ARHGEF17 | S463 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PX6 | CCDC85A | S300 | ochoa | Coiled-coil domain-containing protein 85A | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. {ECO:0000305|PubMed:25009281}. |
| Q96QT4 | TRPM7 | S1407 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96T88 | UHRF1 | S298 | psp | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q9BQG0 | MYBBP1A | S1243 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BY44 | EIF2A | S517 | ochoa | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| Q9BY89 | KIAA1671 | S1366 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZL6 | PRKD2 | S518 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9GZU2 | PEG3 | S196 | ochoa | Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}. |
| Q9GZV5 | WWTR1 | S296 | ochoa | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9H1A4 | ANAPC1 | S536 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H2Y7 | ZNF106 | S1249 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H329 | EPB41L4B | S428 | ochoa | Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}. |
| Q9H4L5 | OSBPL3 | S304 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H4Z3 | PCIF1 | S143 | ochoa | mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) | Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}. |
| Q9H5V8 | CDCP1 | S803 | ochoa | CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318) | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}. |
| Q9H611 | PIF1 | S199 | ochoa | ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}. |
| Q9H6F5 | CCDC86 | S196 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H6S3 | EPS8L2 | S578 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H8N7 | ZNF395 | S468 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9H8Y8 | GORASP2 | S432 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9HCD6 | TANC2 | S430 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCK8 | CHD8 | S277 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NPB6 | PARD6A | S319 | ochoa | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}. |
| Q9NQG1 | MANBAL | S55 | ochoa | Protein MANBAL | None |
| Q9NQU5 | PAK6 | S616 | ochoa | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| Q9NRY4 | ARHGAP35 | S1001 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NW07 | ZNF358 | S484 | ochoa | Zinc finger protein 358 | May be involved in transcriptional regulation. |
| Q9NZB2 | FAM120A | S990 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9NZV7 | ZIM2 | S71 | ochoa | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| Q9P0K7 | RAI14 | S411 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P1Y6 | PHRF1 | S1359 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P227 | ARHGAP23 | S545 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2Q2 | FRMD4A | S673 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UDY2 | TJP2 | S1053 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UIG0 | BAZ1B | S1315 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UIU6 | SIX4 | S640 | ochoa | Homeobox protein SIX4 (Sine oculis homeobox homolog 4) | Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. {ECO:0000250|UniProtKB:Q61321}. |
| Q9UKE5 | TNIK | S707 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9ULU8 | CADPS | S90 | ochoa | Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}. |
| Q9UM11 | FZR1 | S120 | ochoa | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) | Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:14701726, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}. |
| Q9UNN5 | FAF1 | S269 | ochoa | FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) | Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}. |
| Q9UQR0 | SCML2 | S255 | ochoa | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y2H5 | PLEKHA6 | S505 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y4F3 | MARF1 | S687 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q9Y4F5 | CEP170B | S888 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y520 | PRRC2C | S917 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y6Y8 | SEC23IP | S406 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| Q9Y262 | EIF3L | S416 | Sugiyama | Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O43781 | DYRK3 | S54 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) | Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:29634919, PubMed:9748265). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29634919, ECO:0000269|PubMed:29973724, ECO:0000269|PubMed:9748265}. |
| Q96SB3 | PPP1R9B | S94 | ELM|iPTMNet|EPSD | Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin) | Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration. {ECO:0000250, ECO:0000269|PubMed:19151759}. |
| Q9BX68 | HINT2 | S63 | Sugiyama | Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718, ECO:0000269|PubMed:31990367}. |
| Q8IWW6 | ARHGAP12 | S450 | Sugiyama | Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| O15037 | KHNYN | S299 | Sugiyama | Protein KHNYN (KH and NYN domain-containing protein) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.000035 | 4.453 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.000053 | 4.276 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000102 | 3.992 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.000102 | 3.992 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000081 | 4.091 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.000184 | 3.734 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.000205 | 3.688 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.000665 | 3.177 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.000665 | 3.177 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.000665 | 3.177 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.000811 | 3.091 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.000975 | 3.011 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.000975 | 3.011 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.000975 | 3.011 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.000975 | 3.011 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.000975 | 3.011 |
| R-HSA-4839744 | Signaling by APC mutants | 0.000665 | 3.177 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.000811 | 3.091 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.000768 | 3.115 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.001157 | 2.937 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.001173 | 2.931 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.001682 | 2.774 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.001682 | 2.774 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.001591 | 2.798 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.001688 | 2.773 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.001547 | 2.811 |
| R-HSA-195721 | Signaling by WNT | 0.001602 | 2.795 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.001414 | 2.849 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.001488 | 2.827 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.002341 | 2.631 |
| R-HSA-2028269 | Signaling by Hippo | 0.002407 | 2.619 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.002529 | 2.597 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.002529 | 2.597 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.002689 | 2.570 |
| R-HSA-75153 | Apoptotic execution phase | 0.004134 | 2.384 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.004272 | 2.369 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.004763 | 2.322 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.005190 | 2.285 |
| R-HSA-68875 | Mitotic Prophase | 0.005612 | 2.251 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.006227 | 2.206 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.006316 | 2.200 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.007447 | 2.128 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.008107 | 2.091 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.008403 | 2.076 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.009178 | 2.037 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.009178 | 2.037 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.009348 | 2.029 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.010063 | 1.997 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.010063 | 1.997 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.010063 | 1.997 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.010094 | 1.996 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.010516 | 1.978 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.010808 | 1.966 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.011791 | 1.928 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.011584 | 1.936 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.011584 | 1.936 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.012392 | 1.907 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.012392 | 1.907 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.011698 | 1.932 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.014476 | 1.839 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.014538 | 1.837 |
| R-HSA-1640170 | Cell Cycle | 0.013794 | 1.860 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.015821 | 1.801 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.015939 | 1.798 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.016905 | 1.772 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.016385 | 1.786 |
| R-HSA-73887 | Death Receptor Signaling | 0.017451 | 1.758 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.017723 | 1.751 |
| R-HSA-170968 | Frs2-mediated activation | 0.017723 | 1.751 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.019717 | 1.705 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.019999 | 1.699 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.018935 | 1.723 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.019999 | 1.699 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.017904 | 1.747 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.019999 | 1.699 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.019905 | 1.701 |
| R-HSA-162582 | Signal Transduction | 0.020776 | 1.682 |
| R-HSA-9833482 | PKR-mediated signaling | 0.021434 | 1.669 |
| R-HSA-68886 | M Phase | 0.022944 | 1.639 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.023971 | 1.620 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.026226 | 1.581 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.023032 | 1.638 |
| R-HSA-9664420 | Killing mechanisms | 0.023971 | 1.620 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.023971 | 1.620 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.026226 | 1.581 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.025801 | 1.588 |
| R-HSA-169893 | Prolonged ERK activation events | 0.023971 | 1.620 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.023675 | 1.626 |
| R-HSA-3371556 | Cellular response to heat stress | 0.023195 | 1.635 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.027058 | 1.568 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.028563 | 1.544 |
| R-HSA-9675108 | Nervous system development | 0.028572 | 1.544 |
| R-HSA-199991 | Membrane Trafficking | 0.029302 | 1.533 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.029670 | 1.528 |
| R-HSA-2559583 | Cellular Senescence | 0.032395 | 1.490 |
| R-HSA-109704 | PI3K Cascade | 0.032410 | 1.489 |
| R-HSA-5083628 | Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | 0.034961 | 1.456 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.038692 | 1.412 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.041409 | 1.383 |
| R-HSA-112399 | IRS-mediated signalling | 0.042998 | 1.367 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.044175 | 1.355 |
| R-HSA-70171 | Glycolysis | 0.044175 | 1.355 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.046342 | 1.334 |
| R-HSA-5083633 | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 | 0.046342 | 1.334 |
| R-HSA-5083629 | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 | 0.046342 | 1.334 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.049968 | 1.301 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.051491 | 1.288 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.049732 | 1.303 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.049968 | 1.301 |
| R-HSA-376172 | DSCAM interactions | 0.046342 | 1.334 |
| R-HSA-191859 | snRNP Assembly | 0.046304 | 1.334 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.046304 | 1.334 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.049732 | 1.303 |
| R-HSA-180786 | Extension of Telomeres | 0.046304 | 1.334 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.049389 | 1.306 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.052951 | 1.276 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.047721 | 1.321 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.044195 | 1.355 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.049118 | 1.309 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.053018 | 1.276 |
| R-HSA-5660489 | MTF1 activates gene expression | 0.068706 | 1.163 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.068706 | 1.163 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.068706 | 1.163 |
| R-HSA-74713 | IRS activation | 0.079691 | 1.099 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.090548 | 1.043 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.090548 | 1.043 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.090548 | 1.043 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.101277 | 0.994 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.101277 | 0.994 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.111880 | 0.951 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.111880 | 0.951 |
| R-HSA-8932506 | DAG1 core M1 glycosylations | 0.111880 | 0.951 |
| R-HSA-112412 | SOS-mediated signalling | 0.111880 | 0.951 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.111880 | 0.951 |
| R-HSA-8932504 | DAG1 core M2 glycosylations | 0.122359 | 0.912 |
| R-HSA-196025 | Formation of annular gap junctions | 0.122359 | 0.912 |
| R-HSA-8875656 | MET receptor recycling | 0.122359 | 0.912 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.132714 | 0.877 |
| R-HSA-190873 | Gap junction degradation | 0.132714 | 0.877 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.142948 | 0.845 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.153062 | 0.815 |
| R-HSA-8932505 | DAG1 core M3 glycosylations | 0.153062 | 0.815 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.172936 | 0.762 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.059100 | 1.228 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.192345 | 0.716 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.201879 | 0.695 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.201879 | 0.695 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.201879 | 0.695 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.201879 | 0.695 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.201879 | 0.695 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.211301 | 0.675 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.211301 | 0.675 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.220612 | 0.656 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.220612 | 0.656 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.238908 | 0.622 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.247895 | 0.606 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.256777 | 0.590 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.135205 | 0.869 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.135205 | 0.869 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.159682 | 0.797 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.163839 | 0.786 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.163839 | 0.786 |
| R-HSA-72649 | Translation initiation complex formation | 0.168015 | 0.775 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.102083 | 0.991 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.102083 | 0.991 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.172209 | 0.764 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.176421 | 0.753 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.176421 | 0.753 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.193419 | 0.714 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.232314 | 0.634 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.068641 | 1.163 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.068641 | 1.163 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.137982 | 0.860 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.192345 | 0.716 |
| R-HSA-4641258 | Degradation of DVL | 0.096711 | 1.015 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.247895 | 0.606 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.256777 | 0.590 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.142948 | 0.845 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.192345 | 0.716 |
| R-HSA-198203 | PI3K/AKT activation | 0.142948 | 0.845 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.192345 | 0.716 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.201879 | 0.695 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.201879 | 0.695 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.256777 | 0.590 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.111880 | 0.951 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.182697 | 0.738 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.192345 | 0.716 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.229814 | 0.639 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.247895 | 0.606 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.072762 | 1.138 |
| R-HSA-9939291 | Matriglycan biosynthesis on DAG1 | 0.265554 | 0.576 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.172936 | 0.762 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.172936 | 0.762 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.256777 | 0.590 |
| R-HSA-165158 | Activation of AKT2 | 0.079691 | 1.099 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.119413 | 0.923 |
| R-HSA-9609690 | HCMV Early Events | 0.114276 | 0.942 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.068756 | 1.163 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.171663 | 0.765 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.111880 | 0.951 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.132714 | 0.877 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.057082 | 1.244 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.262889 | 0.580 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.135288 | 0.869 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.220612 | 0.656 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.193419 | 0.714 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.132714 | 0.877 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.163058 | 0.788 |
| R-HSA-202670 | ERKs are inactivated | 0.163058 | 0.788 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.172936 | 0.762 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.201879 | 0.695 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.055099 | 1.259 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.055099 | 1.259 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.192345 | 0.716 |
| R-HSA-5689603 | UCH proteinases | 0.262889 | 0.580 |
| R-HSA-9609646 | HCMV Infection | 0.218623 | 0.660 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.059100 | 1.228 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.115541 | 0.937 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.066621 | 1.176 |
| R-HSA-74749 | Signal attenuation | 0.142948 | 0.845 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.201879 | 0.695 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.247895 | 0.606 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.056947 | 1.245 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.111880 | 0.951 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.201879 | 0.695 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.078887 | 1.103 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.093060 | 1.031 |
| R-HSA-68877 | Mitotic Prometaphase | 0.109445 | 0.961 |
| R-HSA-4086400 | PCP/CE pathway | 0.083534 | 1.078 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.092614 | 1.033 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.227961 | 0.642 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.122103 | 0.913 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.163058 | 0.788 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.062263 | 1.206 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.182697 | 0.738 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.065482 | 1.184 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.068756 | 1.163 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.265554 | 0.576 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.076992 | 1.114 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.184891 | 0.733 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.249769 | 0.602 |
| R-HSA-73886 | Chromosome Maintenance | 0.078172 | 1.107 |
| R-HSA-9610379 | HCMV Late Events | 0.155839 | 0.807 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.216529 | 0.664 |
| R-HSA-9842663 | Signaling by LTK | 0.172936 | 0.762 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.135288 | 0.869 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.101277 | 0.994 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.229814 | 0.639 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.247895 | 0.606 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.265554 | 0.576 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.131214 | 0.882 |
| R-HSA-157579 | Telomere Maintenance | 0.137982 | 0.860 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.090548 | 1.043 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.111880 | 0.951 |
| R-HSA-444257 | RSK activation | 0.122359 | 0.912 |
| R-HSA-428540 | Activation of RAC1 | 0.163058 | 0.788 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.211301 | 0.675 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.093060 | 1.031 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.168015 | 0.775 |
| R-HSA-450294 | MAP kinase activation | 0.197702 | 0.704 |
| R-HSA-68882 | Mitotic Anaphase | 0.063627 | 1.196 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.064654 | 1.189 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.068710 | 1.163 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.117840 | 0.929 |
| R-HSA-448424 | Interleukin-17 signaling | 0.236672 | 0.626 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.182697 | 0.738 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.229814 | 0.639 |
| R-HSA-194138 | Signaling by VEGF | 0.086529 | 1.063 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.096711 | 1.015 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.135150 | 0.869 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.079691 | 1.099 |
| R-HSA-448706 | Interleukin-1 processing | 0.132714 | 0.877 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.132714 | 0.877 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.192345 | 0.716 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.075460 | 1.122 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.229814 | 0.639 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.070688 | 1.151 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.193419 | 0.714 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.115023 | 0.939 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.211301 | 0.675 |
| R-HSA-9945266 | Differentiation of T cells | 0.211301 | 0.675 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.238908 | 0.622 |
| R-HSA-445144 | Signal transduction by L1 | 0.256777 | 0.590 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.127250 | 0.895 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.135205 | 0.869 |
| R-HSA-5358508 | Mismatch Repair | 0.238908 | 0.622 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.089450 | 1.048 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.222696 | 0.652 |
| R-HSA-422475 | Axon guidance | 0.137853 | 0.861 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.132714 | 0.877 |
| R-HSA-5578768 | Physiological factors | 0.192345 | 0.716 |
| R-HSA-71262 | Carnitine synthesis | 0.211301 | 0.675 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.093060 | 1.031 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.229814 | 0.639 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.238908 | 0.622 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.058825 | 1.230 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.223614 | 0.651 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.147057 | 0.833 |
| R-HSA-187687 | Signalling to ERKs | 0.089450 | 1.048 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.201879 | 0.695 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.169758 | 0.770 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.206302 | 0.685 |
| R-HSA-8848021 | Signaling by PTK6 | 0.206302 | 0.685 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.123976 | 0.907 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.083136 | 1.080 |
| R-HSA-69239 | Synthesis of DNA | 0.168750 | 0.773 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.201879 | 0.695 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.096711 | 1.015 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.247895 | 0.606 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.256777 | 0.590 |
| R-HSA-198753 | ERK/MAPK targets | 0.265554 | 0.576 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.102083 | 0.991 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.227961 | 0.642 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.173654 | 0.760 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.159682 | 0.797 |
| R-HSA-5688426 | Deubiquitination | 0.229320 | 0.640 |
| R-HSA-5660526 | Response to metal ions | 0.220612 | 0.656 |
| R-HSA-74160 | Gene expression (Transcription) | 0.141481 | 0.849 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.183344 | 0.737 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.176421 | 0.753 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.151720 | 0.819 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.174546 | 0.758 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.210399 | 0.677 |
| R-HSA-109581 | Apoptosis | 0.064581 | 1.190 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.265554 | 0.576 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.064215 | 1.192 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.071795 | 1.144 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.172936 | 0.762 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.238908 | 0.622 |
| R-HSA-373760 | L1CAM interactions | 0.201279 | 0.696 |
| R-HSA-69242 | S Phase | 0.136365 | 0.865 |
| R-HSA-2586552 | Signaling by Leptin | 0.142948 | 0.845 |
| R-HSA-166520 | Signaling by NTRKs | 0.136365 | 0.865 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.189148 | 0.723 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.115670 | 0.937 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.122359 | 0.912 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.132714 | 0.877 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.249769 | 0.602 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.091744 | 1.037 |
| R-HSA-373755 | Semaphorin interactions | 0.053280 | 1.273 |
| R-HSA-201556 | Signaling by ALK | 0.104132 | 0.982 |
| R-HSA-5357801 | Programmed Cell Death | 0.131099 | 0.882 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.256777 | 0.590 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.223614 | 0.651 |
| R-HSA-373753 | Nephrin family interactions | 0.256777 | 0.590 |
| R-HSA-70326 | Glucose metabolism | 0.071795 | 1.144 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.192785 | 0.715 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.200002 | 0.699 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.062410 | 1.205 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.093060 | 1.031 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.262869 | 0.580 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.076992 | 1.114 |
| R-HSA-2262752 | Cellular responses to stress | 0.172890 | 0.762 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.254141 | 0.595 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.104132 | 0.982 |
| R-HSA-913531 | Interferon Signaling | 0.205903 | 0.686 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.220612 | 0.656 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.247895 | 0.606 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.082668 | 1.083 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.180648 | 0.743 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.193419 | 0.714 |
| R-HSA-9679506 | SARS-CoV Infections | 0.246546 | 0.608 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.162552 | 0.789 |
| R-HSA-72306 | tRNA processing | 0.188021 | 0.726 |
| R-HSA-211000 | Gene Silencing by RNA | 0.168750 | 0.773 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.271639 | 0.566 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.273093 | 0.564 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.274228 | 0.562 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.274228 | 0.562 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.274228 | 0.562 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.274228 | 0.562 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.274228 | 0.562 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.274228 | 0.562 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.274944 | 0.561 |
| R-HSA-9659379 | Sensory processing of sound | 0.276013 | 0.559 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.276013 | 0.559 |
| R-HSA-6806834 | Signaling by MET | 0.280385 | 0.552 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.280385 | 0.552 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.280385 | 0.552 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.282694 | 0.549 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.282800 | 0.549 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.282800 | 0.549 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.282800 | 0.549 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.291272 | 0.536 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.291272 | 0.536 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.291272 | 0.536 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.295541 | 0.529 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.297852 | 0.526 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.299644 | 0.523 |
| R-HSA-9865881 | Complex III assembly | 0.299644 | 0.523 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.299644 | 0.523 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.299644 | 0.523 |
| R-HSA-429947 | Deadenylation of mRNA | 0.299644 | 0.523 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.305417 | 0.515 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.307917 | 0.512 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.307917 | 0.512 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.307917 | 0.512 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.307917 | 0.512 |
| R-HSA-420029 | Tight junction interactions | 0.307917 | 0.512 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.307917 | 0.512 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.307917 | 0.512 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.307917 | 0.512 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.310910 | 0.507 |
| R-HSA-70268 | Pyruvate metabolism | 0.315253 | 0.501 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.315253 | 0.501 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.316094 | 0.500 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.316094 | 0.500 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.316094 | 0.500 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.316094 | 0.500 |
| R-HSA-3295583 | TRP channels | 0.316094 | 0.500 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.321596 | 0.493 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.324174 | 0.489 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.324174 | 0.489 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.324174 | 0.489 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.324174 | 0.489 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.324174 | 0.489 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.324174 | 0.489 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.324555 | 0.489 |
| R-HSA-202424 | Downstream TCR signaling | 0.328242 | 0.484 |
| R-HSA-69306 | DNA Replication | 0.331009 | 0.480 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.332159 | 0.479 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.332159 | 0.479 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.332159 | 0.479 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.332159 | 0.479 |
| R-HSA-622312 | Inflammasomes | 0.332159 | 0.479 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.336865 | 0.473 |
| R-HSA-162906 | HIV Infection | 0.336896 | 0.473 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.337463 | 0.472 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.340050 | 0.468 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.340050 | 0.468 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.340050 | 0.468 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.340050 | 0.468 |
| R-HSA-5334118 | DNA methylation | 0.340050 | 0.468 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.340050 | 0.468 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.340050 | 0.468 |
| R-HSA-180024 | DARPP-32 events | 0.340050 | 0.468 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.340050 | 0.468 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.341165 | 0.467 |
| R-HSA-162587 | HIV Life Cycle | 0.343913 | 0.464 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.345456 | 0.462 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.347849 | 0.459 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.347849 | 0.459 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.347849 | 0.459 |
| R-HSA-2424491 | DAP12 signaling | 0.347849 | 0.459 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.347849 | 0.459 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.347849 | 0.459 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.354010 | 0.451 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.355556 | 0.449 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.355556 | 0.449 |
| R-HSA-186763 | Downstream signal transduction | 0.355556 | 0.449 |
| R-HSA-8931838 | DAG1 glycosylations | 0.363172 | 0.440 |
| R-HSA-69190 | DNA strand elongation | 0.363172 | 0.440 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.363172 | 0.440 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.366768 | 0.436 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.370699 | 0.431 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.370699 | 0.431 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.370699 | 0.431 |
| R-HSA-9930044 | Nuclear RNA decay | 0.370699 | 0.431 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.370699 | 0.431 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.370699 | 0.431 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.370699 | 0.431 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.370699 | 0.431 |
| R-HSA-354192 | Integrin signaling | 0.370699 | 0.431 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.370699 | 0.431 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.370999 | 0.431 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.370999 | 0.431 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.370999 | 0.431 |
| R-HSA-5619102 | SLC transporter disorders | 0.376060 | 0.425 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.378137 | 0.422 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.378137 | 0.422 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.383625 | 0.416 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.385488 | 0.414 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.385488 | 0.414 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.385488 | 0.414 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.385488 | 0.414 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.385488 | 0.414 |
| R-HSA-5673000 | RAF activation | 0.385488 | 0.414 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.385488 | 0.414 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.387810 | 0.411 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.387810 | 0.411 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.392025 | 0.407 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.392753 | 0.406 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.392753 | 0.406 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.392753 | 0.406 |
| R-HSA-381042 | PERK regulates gene expression | 0.392753 | 0.406 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.392753 | 0.406 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.396142 | 0.402 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.399931 | 0.398 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.399931 | 0.398 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.399931 | 0.398 |
| R-HSA-3371511 | HSF1 activation | 0.399931 | 0.398 |
| R-HSA-8853659 | RET signaling | 0.399931 | 0.398 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.404422 | 0.393 |
| R-HSA-212436 | Generic Transcription Pathway | 0.406501 | 0.391 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.407026 | 0.390 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.407026 | 0.390 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.407026 | 0.390 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.407026 | 0.390 |
| R-HSA-8875878 | MET promotes cell motility | 0.414037 | 0.383 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.414037 | 0.383 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.416740 | 0.380 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.416740 | 0.380 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.416740 | 0.380 |
| R-HSA-168255 | Influenza Infection | 0.417348 | 0.380 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.420817 | 0.376 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.420966 | 0.376 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.420966 | 0.376 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.420966 | 0.376 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.420966 | 0.376 |
| R-HSA-202403 | TCR signaling | 0.424881 | 0.372 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.424881 | 0.372 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.424881 | 0.372 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.427813 | 0.369 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.427813 | 0.369 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.427813 | 0.369 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.427813 | 0.369 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.427813 | 0.369 |
| R-HSA-5260271 | Diseases of Immune System | 0.427813 | 0.369 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.427813 | 0.369 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.427813 | 0.369 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.429212 | 0.367 |
| R-HSA-597592 | Post-translational protein modification | 0.433939 | 0.363 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.434579 | 0.362 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.434579 | 0.362 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.434579 | 0.362 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.434579 | 0.362 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.434579 | 0.362 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.434579 | 0.362 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.436981 | 0.360 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.440574 | 0.356 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.440985 | 0.356 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.441266 | 0.355 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.441266 | 0.355 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.441266 | 0.355 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.441266 | 0.355 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.441266 | 0.355 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.441266 | 0.355 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.447874 | 0.349 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.448944 | 0.348 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.454405 | 0.343 |
| R-HSA-8854214 | TBC/RABGAPs | 0.454405 | 0.343 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.456840 | 0.340 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.456840 | 0.340 |
| R-HSA-373752 | Netrin-1 signaling | 0.460859 | 0.336 |
| R-HSA-190828 | Gap junction trafficking | 0.460859 | 0.336 |
| R-HSA-2172127 | DAP12 interactions | 0.460859 | 0.336 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.460859 | 0.336 |
| R-HSA-5693538 | Homology Directed Repair | 0.464670 | 0.333 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.467236 | 0.330 |
| R-HSA-774815 | Nucleosome assembly | 0.467236 | 0.330 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.467236 | 0.330 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.467236 | 0.330 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.467236 | 0.330 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.467236 | 0.330 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.467236 | 0.330 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.467236 | 0.330 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.467236 | 0.330 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.468561 | 0.329 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.468561 | 0.329 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.472909 | 0.325 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.473539 | 0.325 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.473539 | 0.325 |
| R-HSA-9675135 | Diseases of DNA repair | 0.473539 | 0.325 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.473539 | 0.325 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.474460 | 0.324 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.476291 | 0.322 |
| R-HSA-9658195 | Leishmania infection | 0.479586 | 0.319 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.479586 | 0.319 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.479768 | 0.319 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.479768 | 0.319 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.479768 | 0.319 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.479768 | 0.319 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.480131 | 0.319 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.480131 | 0.319 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.482141 | 0.317 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.485923 | 0.313 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.490961 | 0.309 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.490961 | 0.309 |
| R-HSA-73893 | DNA Damage Bypass | 0.492005 | 0.308 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.492005 | 0.308 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.498017 | 0.303 |
| R-HSA-9748787 | Azathioprine ADME | 0.498017 | 0.303 |
| R-HSA-1280218 | Adaptive Immune System | 0.501135 | 0.300 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.503957 | 0.298 |
| R-HSA-912446 | Meiotic recombination | 0.503957 | 0.298 |
| R-HSA-72187 | mRNA 3'-end processing | 0.509827 | 0.293 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.509827 | 0.293 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.515629 | 0.288 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.515629 | 0.288 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.517746 | 0.286 |
| R-HSA-9843745 | Adipogenesis | 0.521209 | 0.283 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.524101 | 0.281 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.527027 | 0.278 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.532626 | 0.274 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.532626 | 0.274 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.532626 | 0.274 |
| R-HSA-75893 | TNF signaling | 0.532626 | 0.274 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.543627 | 0.265 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.543627 | 0.265 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.549030 | 0.260 |
| R-HSA-6807070 | PTEN Regulation | 0.553176 | 0.257 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.554370 | 0.256 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.559646 | 0.252 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.559646 | 0.252 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.564861 | 0.248 |
| R-HSA-1268020 | Mitochondrial protein import | 0.564861 | 0.248 |
| R-HSA-186797 | Signaling by PDGF | 0.564861 | 0.248 |
| R-HSA-9707616 | Heme signaling | 0.564861 | 0.248 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.564861 | 0.248 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.570014 | 0.244 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.570014 | 0.244 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.570014 | 0.244 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.570014 | 0.244 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.570278 | 0.244 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.573642 | 0.241 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.575107 | 0.240 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.581453 | 0.235 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.585112 | 0.233 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.586905 | 0.231 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.599861 | 0.222 |
| R-HSA-9609507 | Protein localization | 0.603053 | 0.220 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.604426 | 0.219 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.604426 | 0.219 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.604426 | 0.219 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.609113 | 0.215 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.609113 | 0.215 |
| R-HSA-3000178 | ECM proteoglycans | 0.609113 | 0.215 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.609113 | 0.215 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.613745 | 0.212 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.613745 | 0.212 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.615213 | 0.211 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.618322 | 0.209 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.618723 | 0.209 |
| R-HSA-4839726 | Chromatin organization | 0.620242 | 0.207 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.622845 | 0.206 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.622845 | 0.206 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.624857 | 0.204 |
| R-HSA-380287 | Centrosome maturation | 0.627315 | 0.203 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.627315 | 0.203 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.636097 | 0.196 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.648886 | 0.188 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.648886 | 0.188 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.652773 | 0.185 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.653048 | 0.185 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.661227 | 0.180 |
| R-HSA-73894 | DNA Repair | 0.661954 | 0.179 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.665244 | 0.177 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.665244 | 0.177 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.665787 | 0.177 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.667966 | 0.175 |
| R-HSA-1500620 | Meiosis | 0.669214 | 0.174 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.673137 | 0.172 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.677014 | 0.169 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.684630 | 0.165 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.692068 | 0.160 |
| R-HSA-73884 | Base Excision Repair | 0.692068 | 0.160 |
| R-HSA-69275 | G2/M Transition | 0.700320 | 0.155 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.702899 | 0.153 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.705379 | 0.152 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.706425 | 0.151 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.709909 | 0.149 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.712835 | 0.147 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.716753 | 0.145 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.720115 | 0.143 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.720115 | 0.143 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.720115 | 0.143 |
| R-HSA-190236 | Signaling by FGFR | 0.726720 | 0.139 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.729965 | 0.137 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.733171 | 0.135 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.733171 | 0.135 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.734262 | 0.134 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.736339 | 0.133 |
| R-HSA-1483255 | PI Metabolism | 0.739469 | 0.131 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.745620 | 0.127 |
| R-HSA-111885 | Opioid Signalling | 0.745620 | 0.127 |
| R-HSA-9833110 | RSV-host interactions | 0.748641 | 0.126 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.751626 | 0.124 |
| R-HSA-418346 | Platelet homeostasis | 0.754576 | 0.122 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.760372 | 0.119 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.760372 | 0.119 |
| R-HSA-397014 | Muscle contraction | 0.762813 | 0.118 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.762813 | 0.118 |
| R-HSA-1500931 | Cell-Cell communication | 0.762826 | 0.118 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.764895 | 0.116 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.766032 | 0.116 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.771558 | 0.113 |
| R-HSA-8957322 | Metabolism of steroids | 0.776572 | 0.110 |
| R-HSA-8951664 | Neddylation | 0.780995 | 0.107 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.784813 | 0.105 |
| R-HSA-1474244 | Extracellular matrix organization | 0.788062 | 0.103 |
| R-HSA-1643685 | Disease | 0.793350 | 0.101 |
| R-HSA-1266738 | Developmental Biology | 0.799952 | 0.097 |
| R-HSA-8953854 | Metabolism of RNA | 0.800637 | 0.097 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.803627 | 0.095 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.804448 | 0.095 |
| R-HSA-8939211 | ESR-mediated signaling | 0.810329 | 0.091 |
| R-HSA-69206 | G1/S Transition | 0.811342 | 0.091 |
| R-HSA-69481 | G2/M Checkpoints | 0.815804 | 0.088 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.818482 | 0.087 |
| R-HSA-1474165 | Reproduction | 0.824414 | 0.084 |
| R-HSA-5576891 | Cardiac conduction | 0.826503 | 0.083 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.828568 | 0.082 |
| R-HSA-9909396 | Circadian clock | 0.828568 | 0.082 |
| R-HSA-421270 | Cell-cell junction organization | 0.833082 | 0.079 |
| R-HSA-163685 | Integration of energy metabolism | 0.838529 | 0.076 |
| R-HSA-5173105 | O-linked glycosylation | 0.840451 | 0.075 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.840451 | 0.075 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.842351 | 0.075 |
| R-HSA-109582 | Hemostasis | 0.845483 | 0.073 |
| R-HSA-9664407 | Parasite infection | 0.846082 | 0.073 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.846082 | 0.073 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.846082 | 0.073 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.847915 | 0.072 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.850603 | 0.070 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.858464 | 0.066 |
| R-HSA-392499 | Metabolism of proteins | 0.860118 | 0.065 |
| R-HSA-9758941 | Gastrulation | 0.863462 | 0.064 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.865089 | 0.063 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.865089 | 0.063 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.865182 | 0.063 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.868285 | 0.061 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.868285 | 0.061 |
| R-HSA-446728 | Cell junction organization | 0.870154 | 0.060 |
| R-HSA-1989781 | PPARA activates gene expression | 0.872938 | 0.059 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.875949 | 0.058 |
| R-HSA-9711097 | Cellular response to starvation | 0.877428 | 0.057 |
| R-HSA-9824446 | Viral Infection Pathways | 0.880271 | 0.055 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.895128 | 0.048 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.898837 | 0.046 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.898837 | 0.046 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.898837 | 0.046 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.900044 | 0.046 |
| R-HSA-611105 | Respiratory electron transport | 0.904731 | 0.043 |
| R-HSA-3781865 | Diseases of glycosylation | 0.911355 | 0.040 |
| R-HSA-388396 | GPCR downstream signalling | 0.913518 | 0.039 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.915514 | 0.038 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.915583 | 0.038 |
| R-HSA-983712 | Ion channel transport | 0.916524 | 0.038 |
| R-HSA-5617833 | Cilium Assembly | 0.917521 | 0.037 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.923259 | 0.035 |
| R-HSA-6798695 | Neutrophil degranulation | 0.924586 | 0.034 |
| R-HSA-428157 | Sphingolipid metabolism | 0.927737 | 0.033 |
| R-HSA-168256 | Immune System | 0.931234 | 0.031 |
| R-HSA-418990 | Adherens junctions interactions | 0.941809 | 0.026 |
| R-HSA-9748784 | Drug ADME | 0.941809 | 0.026 |
| R-HSA-449147 | Signaling by Interleukins | 0.950160 | 0.022 |
| R-HSA-72312 | rRNA processing | 0.950838 | 0.022 |
| R-HSA-372790 | Signaling by GPCR | 0.951562 | 0.022 |
| R-HSA-15869 | Metabolism of nucleotides | 0.953152 | 0.021 |
| R-HSA-72766 | Translation | 0.971077 | 0.013 |
| R-HSA-5663205 | Infectious disease | 0.972815 | 0.012 |
| R-HSA-1483257 | Phospholipid metabolism | 0.977024 | 0.010 |
| R-HSA-112316 | Neuronal System | 0.980681 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 0.981001 | 0.008 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.983024 | 0.007 |
| R-HSA-168249 | Innate Immune System | 0.992212 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.993418 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 0.994173 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.995434 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999562 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999948 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999997 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.803 | 0.219 | 1 | 0.833 |
CLK3 |
0.802 | 0.171 | 1 | 0.762 |
HIPK4 |
0.801 | 0.211 | 1 | 0.724 |
COT |
0.798 | 0.009 | 2 | 0.111 |
PIM3 |
0.794 | 0.107 | -3 | 0.808 |
NDR2 |
0.793 | 0.085 | -3 | 0.809 |
PRKD1 |
0.793 | 0.178 | -3 | 0.795 |
MOS |
0.791 | 0.136 | 1 | 0.812 |
KIS |
0.790 | 0.116 | 1 | 0.613 |
AURC |
0.790 | 0.144 | -2 | 0.728 |
RSK2 |
0.789 | 0.084 | -3 | 0.743 |
CHAK2 |
0.788 | 0.203 | -1 | 0.793 |
PRKD2 |
0.788 | 0.145 | -3 | 0.740 |
SKMLCK |
0.788 | 0.099 | -2 | 0.897 |
TGFBR2 |
0.786 | 0.055 | -2 | 0.830 |
PRPK |
0.784 | -0.022 | -1 | 0.824 |
P90RSK |
0.783 | 0.062 | -3 | 0.745 |
CAMK1B |
0.782 | 0.017 | -3 | 0.839 |
ATR |
0.782 | 0.058 | 1 | 0.793 |
MTOR |
0.782 | 0.011 | 1 | 0.750 |
NLK |
0.782 | 0.003 | 1 | 0.776 |
TBK1 |
0.782 | -0.020 | 1 | 0.723 |
GRK1 |
0.781 | 0.063 | -2 | 0.813 |
NDR1 |
0.781 | 0.028 | -3 | 0.806 |
SRPK1 |
0.781 | 0.075 | -3 | 0.725 |
GCN2 |
0.781 | -0.125 | 2 | 0.116 |
BMPR1B |
0.781 | 0.159 | 1 | 0.867 |
AMPKA1 |
0.781 | 0.098 | -3 | 0.832 |
RAF1 |
0.780 | 0.018 | 1 | 0.829 |
LATS2 |
0.780 | 0.055 | -5 | 0.824 |
IKKB |
0.779 | -0.020 | -2 | 0.722 |
PIM1 |
0.778 | 0.075 | -3 | 0.756 |
NUAK2 |
0.778 | 0.011 | -3 | 0.819 |
MAPKAPK2 |
0.778 | 0.079 | -3 | 0.697 |
DAPK2 |
0.778 | 0.097 | -3 | 0.846 |
PKCD |
0.777 | 0.013 | 2 | 0.120 |
MST4 |
0.777 | 0.021 | 2 | 0.178 |
RSK4 |
0.777 | 0.084 | -3 | 0.706 |
MAPKAPK3 |
0.777 | 0.063 | -3 | 0.751 |
PKACG |
0.777 | 0.062 | -2 | 0.773 |
AMPKA2 |
0.777 | 0.097 | -3 | 0.795 |
CDKL5 |
0.777 | 0.023 | -3 | 0.766 |
RSK3 |
0.777 | 0.041 | -3 | 0.732 |
CDKL1 |
0.777 | 0.012 | -3 | 0.772 |
ULK2 |
0.776 | -0.138 | 2 | 0.116 |
PKN2 |
0.776 | -0.014 | -3 | 0.819 |
IKKE |
0.776 | -0.026 | 1 | 0.722 |
BMPR2 |
0.776 | -0.031 | -2 | 0.880 |
CAMLCK |
0.776 | 0.052 | -2 | 0.878 |
CLK2 |
0.776 | 0.110 | -3 | 0.726 |
ICK |
0.775 | 0.059 | -3 | 0.811 |
PAK1 |
0.775 | 0.036 | -2 | 0.839 |
GRK5 |
0.775 | -0.022 | -3 | 0.847 |
NEK6 |
0.775 | -0.017 | -2 | 0.854 |
CAMK2G |
0.775 | -0.101 | 2 | 0.120 |
CAMK2D |
0.774 | -0.015 | -3 | 0.820 |
PKCA |
0.774 | 0.008 | 2 | 0.109 |
MARK4 |
0.774 | 0.012 | 4 | 0.867 |
CAMK2A |
0.774 | 0.031 | 2 | 0.119 |
BRSK1 |
0.774 | 0.019 | -3 | 0.763 |
NIK |
0.774 | -0.007 | -3 | 0.859 |
HIPK2 |
0.773 | 0.098 | 1 | 0.552 |
ERK5 |
0.773 | -0.022 | 1 | 0.725 |
PKN3 |
0.773 | -0.035 | -3 | 0.797 |
PDHK4 |
0.773 | -0.159 | 1 | 0.812 |
PKACB |
0.773 | 0.107 | -2 | 0.731 |
DSTYK |
0.772 | -0.099 | 2 | 0.123 |
WNK1 |
0.772 | -0.065 | -2 | 0.879 |
TSSK1 |
0.772 | 0.031 | -3 | 0.850 |
AURB |
0.772 | 0.093 | -2 | 0.722 |
MLK3 |
0.772 | -0.039 | 2 | 0.100 |
P70S6KB |
0.772 | 0.030 | -3 | 0.768 |
GRK7 |
0.772 | 0.095 | 1 | 0.770 |
TSSK2 |
0.772 | -0.002 | -5 | 0.877 |
FAM20C |
0.771 | -0.062 | 2 | 0.063 |
PAK3 |
0.771 | 0.013 | -2 | 0.824 |
ALK4 |
0.771 | 0.083 | -2 | 0.846 |
LATS1 |
0.771 | 0.103 | -3 | 0.821 |
MLK1 |
0.770 | -0.123 | 2 | 0.103 |
TGFBR1 |
0.770 | 0.079 | -2 | 0.825 |
CAMK2B |
0.770 | -0.009 | 2 | 0.102 |
PKCB |
0.770 | -0.021 | 2 | 0.093 |
IKKA |
0.770 | 0.014 | -2 | 0.716 |
PRKX |
0.770 | 0.125 | -3 | 0.657 |
PDHK1 |
0.770 | -0.107 | 1 | 0.788 |
RIPK3 |
0.770 | -0.083 | 3 | 0.697 |
SRPK2 |
0.770 | 0.053 | -3 | 0.641 |
DYRK2 |
0.769 | 0.031 | 1 | 0.634 |
PKCG |
0.769 | -0.022 | 2 | 0.096 |
PKG2 |
0.769 | 0.067 | -2 | 0.719 |
MNK1 |
0.769 | 0.038 | -2 | 0.827 |
BRSK2 |
0.769 | -0.006 | -3 | 0.796 |
MNK2 |
0.769 | 0.015 | -2 | 0.824 |
HUNK |
0.769 | -0.117 | 2 | 0.094 |
CLK4 |
0.768 | 0.070 | -3 | 0.744 |
CDK7 |
0.768 | 0.051 | 1 | 0.615 |
TTBK2 |
0.767 | -0.129 | 2 | 0.084 |
QSK |
0.767 | 0.062 | 4 | 0.852 |
HIPK1 |
0.767 | 0.080 | 1 | 0.647 |
PHKG1 |
0.767 | -0.019 | -3 | 0.802 |
CLK1 |
0.767 | 0.066 | -3 | 0.721 |
MSK1 |
0.767 | 0.050 | -3 | 0.719 |
MLK2 |
0.767 | -0.046 | 2 | 0.145 |
CDK8 |
0.766 | 0.005 | 1 | 0.602 |
MASTL |
0.766 | -0.106 | -2 | 0.799 |
NEK7 |
0.766 | -0.126 | -3 | 0.826 |
ULK1 |
0.766 | -0.171 | -3 | 0.795 |
GRK6 |
0.766 | -0.038 | 1 | 0.848 |
PAK6 |
0.766 | 0.033 | -2 | 0.748 |
PRKD3 |
0.765 | 0.047 | -3 | 0.715 |
IRE1 |
0.765 | -0.093 | 1 | 0.742 |
AURA |
0.765 | 0.066 | -2 | 0.712 |
CDK19 |
0.765 | 0.021 | 1 | 0.567 |
PAK2 |
0.764 | 0.011 | -2 | 0.821 |
SRPK3 |
0.764 | 0.030 | -3 | 0.690 |
CAMK4 |
0.764 | -0.030 | -3 | 0.797 |
CHAK1 |
0.764 | 0.031 | 2 | 0.222 |
ACVR2B |
0.763 | 0.107 | -2 | 0.819 |
ACVR2A |
0.763 | 0.076 | -2 | 0.811 |
PKCH |
0.763 | -0.049 | 2 | 0.082 |
PLK1 |
0.763 | -0.040 | -2 | 0.806 |
MYLK4 |
0.763 | 0.034 | -2 | 0.818 |
NIM1 |
0.763 | -0.081 | 3 | 0.743 |
GRK4 |
0.762 | -0.087 | -2 | 0.843 |
CDK1 |
0.762 | 0.036 | 1 | 0.602 |
DLK |
0.762 | -0.091 | 1 | 0.821 |
IRE2 |
0.762 | -0.071 | 2 | 0.104 |
MSK2 |
0.762 | -0.001 | -3 | 0.712 |
MARK3 |
0.762 | 0.035 | 4 | 0.817 |
PKCZ |
0.761 | -0.028 | 2 | 0.124 |
SGK3 |
0.761 | 0.025 | -3 | 0.743 |
WNK3 |
0.761 | -0.193 | 1 | 0.775 |
MELK |
0.761 | -0.028 | -3 | 0.782 |
GRK2 |
0.760 | 0.042 | -2 | 0.736 |
NEK9 |
0.760 | -0.140 | 2 | 0.130 |
RIPK1 |
0.760 | -0.128 | 1 | 0.782 |
PIM2 |
0.760 | 0.066 | -3 | 0.720 |
AKT2 |
0.760 | 0.048 | -3 | 0.663 |
BCKDK |
0.759 | -0.130 | -1 | 0.726 |
HIPK3 |
0.759 | 0.050 | 1 | 0.641 |
TLK2 |
0.759 | 0.005 | 1 | 0.776 |
CDK18 |
0.759 | 0.030 | 1 | 0.549 |
MLK4 |
0.759 | -0.099 | 2 | 0.075 |
QIK |
0.759 | -0.046 | -3 | 0.817 |
ATM |
0.758 | -0.021 | 1 | 0.745 |
NUAK1 |
0.758 | -0.019 | -3 | 0.760 |
BMPR1A |
0.758 | 0.099 | 1 | 0.834 |
ANKRD3 |
0.758 | -0.139 | 1 | 0.818 |
SMG1 |
0.758 | 0.021 | 1 | 0.742 |
JNK2 |
0.758 | 0.014 | 1 | 0.574 |
SIK |
0.758 | 0.022 | -3 | 0.729 |
DNAPK |
0.757 | 0.017 | 1 | 0.708 |
DYRK1A |
0.757 | 0.035 | 1 | 0.666 |
CDK5 |
0.757 | 0.000 | 1 | 0.634 |
DCAMKL1 |
0.757 | -0.001 | -3 | 0.758 |
DRAK1 |
0.757 | -0.007 | 1 | 0.879 |
PLK4 |
0.756 | -0.120 | 2 | 0.074 |
YSK4 |
0.756 | -0.067 | 1 | 0.764 |
NEK2 |
0.756 | -0.064 | 2 | 0.157 |
PKR |
0.756 | -0.070 | 1 | 0.790 |
SSTK |
0.756 | -0.002 | 4 | 0.833 |
PASK |
0.756 | 0.077 | -3 | 0.824 |
ALK2 |
0.756 | 0.026 | -2 | 0.832 |
ERK7 |
0.755 | -0.040 | 2 | 0.071 |
MEK1 |
0.755 | -0.080 | 2 | 0.149 |
SNRK |
0.755 | -0.120 | 2 | 0.103 |
DYRK4 |
0.755 | 0.011 | 1 | 0.564 |
PKACA |
0.755 | 0.072 | -2 | 0.683 |
MARK2 |
0.755 | -0.002 | 4 | 0.786 |
CDK13 |
0.755 | -0.011 | 1 | 0.587 |
CK1E |
0.754 | 0.012 | -3 | 0.578 |
PLK3 |
0.754 | -0.082 | 2 | 0.094 |
P38A |
0.754 | 0.007 | 1 | 0.637 |
MST3 |
0.754 | 0.016 | 2 | 0.153 |
MPSK1 |
0.753 | 0.083 | 1 | 0.714 |
P38B |
0.753 | 0.022 | 1 | 0.565 |
DCAMKL2 |
0.753 | -0.038 | -3 | 0.784 |
VRK2 |
0.753 | -0.126 | 1 | 0.798 |
ERK1 |
0.752 | -0.001 | 1 | 0.560 |
PKCE |
0.752 | 0.003 | 2 | 0.100 |
JNK3 |
0.752 | -0.012 | 1 | 0.592 |
CDK10 |
0.751 | 0.027 | 1 | 0.588 |
P38G |
0.751 | 0.000 | 1 | 0.506 |
DYRK1B |
0.751 | 0.034 | 1 | 0.602 |
MARK1 |
0.751 | -0.015 | 4 | 0.828 |
CDK17 |
0.751 | 0.005 | 1 | 0.510 |
PKCT |
0.750 | -0.043 | 2 | 0.092 |
PERK |
0.750 | -0.076 | -2 | 0.835 |
CDK12 |
0.750 | -0.009 | 1 | 0.564 |
BUB1 |
0.749 | 0.172 | -5 | 0.833 |
CK1D |
0.749 | 0.042 | -3 | 0.534 |
CDK3 |
0.749 | 0.024 | 1 | 0.525 |
AKT1 |
0.749 | 0.041 | -3 | 0.684 |
TLK1 |
0.749 | -0.050 | -2 | 0.851 |
CAMK1G |
0.749 | -0.046 | -3 | 0.731 |
CHK1 |
0.749 | 0.000 | -3 | 0.790 |
GRK3 |
0.748 | 0.026 | -2 | 0.704 |
CDK14 |
0.748 | 0.008 | 1 | 0.601 |
P38D |
0.748 | 0.034 | 1 | 0.497 |
PKCI |
0.748 | -0.034 | 2 | 0.109 |
DYRK3 |
0.748 | 0.031 | 1 | 0.647 |
PRP4 |
0.748 | 0.017 | -3 | 0.790 |
CDK9 |
0.747 | -0.030 | 1 | 0.594 |
PAK5 |
0.746 | 0.024 | -2 | 0.711 |
P70S6K |
0.746 | 0.005 | -3 | 0.676 |
PAK4 |
0.746 | 0.020 | -2 | 0.724 |
TTBK1 |
0.746 | -0.131 | 2 | 0.067 |
GSK3B |
0.746 | 0.033 | 4 | 0.508 |
CK1G1 |
0.746 | -0.020 | -3 | 0.568 |
CK1A2 |
0.745 | 0.019 | -3 | 0.532 |
SMMLCK |
0.745 | 0.002 | -3 | 0.792 |
TAO3 |
0.745 | 0.017 | 1 | 0.779 |
MEK5 |
0.745 | -0.145 | 2 | 0.134 |
MAK |
0.745 | 0.085 | -2 | 0.816 |
IRAK4 |
0.745 | -0.108 | 1 | 0.739 |
GSK3A |
0.744 | 0.042 | 4 | 0.513 |
CAMK1D |
0.744 | 0.009 | -3 | 0.664 |
GCK |
0.744 | 0.093 | 1 | 0.840 |
PHKG2 |
0.743 | -0.073 | -3 | 0.775 |
ERK2 |
0.743 | -0.049 | 1 | 0.611 |
DAPK3 |
0.743 | 0.059 | -3 | 0.774 |
CDK2 |
0.743 | -0.047 | 1 | 0.687 |
HRI |
0.743 | -0.123 | -2 | 0.852 |
MEKK2 |
0.742 | -0.131 | 2 | 0.111 |
WNK4 |
0.742 | -0.131 | -2 | 0.864 |
MAPKAPK5 |
0.742 | -0.067 | -3 | 0.689 |
CDK16 |
0.742 | 0.006 | 1 | 0.518 |
NEK5 |
0.741 | -0.083 | 1 | 0.784 |
ZAK |
0.741 | -0.139 | 1 | 0.752 |
MEKK3 |
0.741 | -0.169 | 1 | 0.796 |
LKB1 |
0.741 | 0.118 | -3 | 0.831 |
AKT3 |
0.741 | 0.047 | -3 | 0.599 |
DAPK1 |
0.740 | 0.053 | -3 | 0.758 |
YANK3 |
0.740 | -0.036 | 2 | 0.044 |
NEK11 |
0.739 | -0.067 | 1 | 0.792 |
HPK1 |
0.739 | 0.064 | 1 | 0.827 |
ROCK2 |
0.739 | 0.075 | -3 | 0.767 |
MEKK1 |
0.739 | -0.141 | 1 | 0.762 |
MOK |
0.738 | 0.069 | 1 | 0.653 |
SGK1 |
0.738 | 0.044 | -3 | 0.582 |
CK2A2 |
0.738 | 0.021 | 1 | 0.754 |
BRAF |
0.737 | -0.117 | -4 | 0.789 |
PKN1 |
0.736 | -0.038 | -3 | 0.702 |
MRCKA |
0.736 | 0.061 | -3 | 0.729 |
MAP3K15 |
0.736 | -0.030 | 1 | 0.732 |
CHK2 |
0.736 | 0.014 | -3 | 0.610 |
KHS2 |
0.736 | 0.079 | 1 | 0.816 |
TNIK |
0.736 | 0.038 | 3 | 0.857 |
PINK1 |
0.735 | -0.068 | 1 | 0.753 |
KHS1 |
0.735 | 0.081 | 1 | 0.783 |
GAK |
0.734 | -0.030 | 1 | 0.790 |
HGK |
0.734 | 0.011 | 3 | 0.853 |
STK33 |
0.734 | -0.108 | 2 | 0.083 |
MEKK6 |
0.734 | -0.079 | 1 | 0.760 |
MRCKB |
0.734 | 0.039 | -3 | 0.712 |
MINK |
0.734 | 0.024 | 1 | 0.791 |
TAO2 |
0.733 | -0.066 | 2 | 0.153 |
NEK8 |
0.733 | -0.137 | 2 | 0.129 |
LOK |
0.733 | 0.010 | -2 | 0.758 |
PLK2 |
0.733 | -0.048 | -3 | 0.742 |
EEF2K |
0.733 | -0.068 | 3 | 0.821 |
PDK1 |
0.732 | -0.053 | 1 | 0.749 |
NEK4 |
0.732 | -0.043 | 1 | 0.767 |
JNK1 |
0.732 | -0.021 | 1 | 0.562 |
CAMK1A |
0.731 | 0.002 | -3 | 0.620 |
MST2 |
0.730 | -0.060 | 1 | 0.808 |
CDK6 |
0.730 | -0.019 | 1 | 0.568 |
CK2A1 |
0.730 | 0.016 | 1 | 0.750 |
CAMKK2 |
0.729 | -0.031 | -2 | 0.718 |
TAK1 |
0.729 | -0.067 | 1 | 0.814 |
CK1A |
0.729 | 0.046 | -3 | 0.446 |
SLK |
0.729 | 0.003 | -2 | 0.711 |
CAMKK1 |
0.728 | -0.110 | -2 | 0.717 |
DMPK1 |
0.727 | 0.065 | -3 | 0.734 |
PBK |
0.727 | 0.047 | 1 | 0.694 |
NEK1 |
0.726 | -0.035 | 1 | 0.758 |
LRRK2 |
0.726 | -0.092 | 2 | 0.148 |
MST1 |
0.725 | -0.032 | 1 | 0.788 |
IRAK1 |
0.725 | -0.217 | -1 | 0.699 |
PKG1 |
0.725 | 0.008 | -2 | 0.647 |
CDK4 |
0.724 | -0.026 | 1 | 0.549 |
CRIK |
0.724 | 0.070 | -3 | 0.677 |
PDHK3_TYR |
0.723 | 0.183 | 4 | 0.887 |
VRK1 |
0.722 | -0.148 | 2 | 0.113 |
SBK |
0.722 | 0.019 | -3 | 0.540 |
YSK1 |
0.721 | -0.081 | 2 | 0.137 |
ROCK1 |
0.720 | 0.032 | -3 | 0.729 |
TTK |
0.718 | -0.012 | -2 | 0.844 |
HASPIN |
0.717 | -0.023 | -1 | 0.649 |
MEK2 |
0.717 | -0.142 | 2 | 0.146 |
OSR1 |
0.716 | -0.050 | 2 | 0.141 |
MYO3B |
0.715 | -0.002 | 2 | 0.179 |
TESK1_TYR |
0.714 | 0.082 | 3 | 0.865 |
LIMK2_TYR |
0.714 | 0.133 | -3 | 0.874 |
MAP2K4_TYR |
0.713 | 0.107 | -1 | 0.830 |
PDHK4_TYR |
0.712 | 0.063 | 2 | 0.177 |
RIPK2 |
0.711 | -0.211 | 1 | 0.710 |
ASK1 |
0.710 | -0.083 | 1 | 0.712 |
PKMYT1_TYR |
0.710 | 0.054 | 3 | 0.835 |
MAP2K6_TYR |
0.710 | 0.016 | -1 | 0.819 |
NEK3 |
0.709 | -0.120 | 1 | 0.702 |
MYO3A |
0.709 | -0.037 | 1 | 0.769 |
PDHK1_TYR |
0.708 | 0.018 | -1 | 0.825 |
MAP2K7_TYR |
0.707 | -0.114 | 2 | 0.154 |
BIKE |
0.706 | -0.014 | 1 | 0.656 |
BMPR2_TYR |
0.706 | -0.012 | -1 | 0.784 |
TAO1 |
0.706 | -0.067 | 1 | 0.699 |
TXK |
0.704 | 0.079 | 1 | 0.850 |
YANK2 |
0.704 | -0.055 | 2 | 0.037 |
EPHA6 |
0.703 | -0.056 | -1 | 0.782 |
EPHB4 |
0.701 | -0.029 | -1 | 0.779 |
ROS1 |
0.701 | -0.005 | 3 | 0.743 |
RET |
0.699 | -0.053 | 1 | 0.747 |
PINK1_TYR |
0.699 | -0.152 | 1 | 0.785 |
ALPHAK3 |
0.699 | -0.063 | -1 | 0.725 |
LIMK1_TYR |
0.698 | -0.080 | 2 | 0.164 |
TYRO3 |
0.698 | -0.084 | 3 | 0.774 |
FGR |
0.698 | 0.008 | 1 | 0.808 |
ABL2 |
0.698 | 0.012 | -1 | 0.761 |
TNK2 |
0.697 | 0.030 | 3 | 0.727 |
AAK1 |
0.696 | 0.027 | 1 | 0.553 |
JAK1 |
0.696 | 0.087 | 1 | 0.701 |
TYK2 |
0.695 | -0.064 | 1 | 0.736 |
JAK2 |
0.695 | -0.045 | 1 | 0.729 |
MST1R |
0.694 | -0.081 | 3 | 0.783 |
CSF1R |
0.694 | -0.063 | 3 | 0.763 |
ABL1 |
0.694 | -0.014 | -1 | 0.759 |
EPHA4 |
0.694 | -0.068 | 2 | 0.114 |
ITK |
0.693 | -0.038 | -1 | 0.747 |
NEK10_TYR |
0.693 | 0.048 | 1 | 0.647 |
INSRR |
0.692 | -0.050 | 3 | 0.712 |
STLK3 |
0.692 | -0.143 | 1 | 0.725 |
YES1 |
0.692 | -0.048 | -1 | 0.831 |
TNNI3K_TYR |
0.691 | -0.026 | 1 | 0.714 |
MERTK |
0.691 | -0.047 | 3 | 0.741 |
SRMS |
0.691 | -0.057 | 1 | 0.828 |
FER |
0.690 | -0.068 | 1 | 0.816 |
TNK1 |
0.690 | -0.030 | 3 | 0.756 |
DDR1 |
0.690 | -0.129 | 4 | 0.805 |
EPHB1 |
0.689 | -0.056 | 1 | 0.815 |
LCK |
0.689 | 0.023 | -1 | 0.777 |
PTK2B |
0.688 | -0.002 | -1 | 0.755 |
JAK3 |
0.688 | -0.084 | 1 | 0.730 |
BMX |
0.688 | -0.021 | -1 | 0.685 |
HCK |
0.687 | -0.054 | -1 | 0.781 |
EPHB3 |
0.687 | -0.081 | -1 | 0.762 |
ALK |
0.687 | -0.032 | 3 | 0.690 |
PDGFRB |
0.686 | -0.118 | 3 | 0.771 |
CK1G3 |
0.686 | -0.023 | -3 | 0.400 |
AXL |
0.686 | -0.080 | 3 | 0.735 |
EPHB2 |
0.686 | -0.075 | -1 | 0.751 |
BLK |
0.685 | 0.001 | -1 | 0.780 |
KIT |
0.685 | -0.087 | 3 | 0.762 |
TEC |
0.684 | -0.051 | -1 | 0.721 |
FGFR2 |
0.683 | -0.150 | 3 | 0.759 |
PTK6 |
0.683 | -0.058 | -1 | 0.710 |
KDR |
0.683 | -0.109 | 3 | 0.717 |
EPHA7 |
0.682 | -0.079 | 2 | 0.108 |
PDGFRA |
0.682 | -0.113 | 3 | 0.772 |
WEE1_TYR |
0.682 | -0.082 | -1 | 0.711 |
LTK |
0.681 | -0.089 | 3 | 0.712 |
MET |
0.681 | -0.065 | 3 | 0.753 |
PTK2 |
0.680 | -0.013 | -1 | 0.694 |
FYN |
0.680 | -0.040 | -1 | 0.768 |
FGFR1 |
0.680 | -0.136 | 3 | 0.730 |
TEK |
0.679 | -0.146 | 3 | 0.703 |
EPHA3 |
0.679 | -0.122 | 2 | 0.103 |
FLT3 |
0.678 | -0.150 | 3 | 0.772 |
DDR2 |
0.677 | -0.041 | 3 | 0.697 |
BTK |
0.676 | -0.144 | -1 | 0.729 |
NTRK1 |
0.676 | -0.130 | -1 | 0.769 |
EPHA1 |
0.675 | -0.112 | 3 | 0.729 |
INSR |
0.675 | -0.104 | 3 | 0.691 |
FRK |
0.675 | -0.107 | -1 | 0.777 |
ERBB2 |
0.674 | -0.130 | 1 | 0.728 |
FLT1 |
0.673 | -0.132 | -1 | 0.742 |
NTRK3 |
0.673 | -0.068 | -1 | 0.732 |
EPHA5 |
0.673 | -0.111 | 2 | 0.096 |
FGFR3 |
0.673 | -0.157 | 3 | 0.726 |
EPHA8 |
0.671 | -0.085 | -1 | 0.731 |
NTRK2 |
0.670 | -0.142 | 3 | 0.715 |
LYN |
0.669 | -0.088 | 3 | 0.682 |
SRC |
0.669 | -0.072 | -1 | 0.780 |
MATK |
0.669 | -0.093 | -1 | 0.682 |
SYK |
0.669 | -0.030 | -1 | 0.691 |
EGFR |
0.668 | -0.094 | 1 | 0.635 |
CK1G2 |
0.668 | -0.027 | -3 | 0.488 |
FLT4 |
0.668 | -0.184 | 3 | 0.715 |
CSK |
0.667 | -0.130 | 2 | 0.109 |
FGFR4 |
0.665 | -0.107 | -1 | 0.719 |
EPHA2 |
0.662 | -0.103 | -1 | 0.691 |
IGF1R |
0.662 | -0.105 | 3 | 0.627 |
MUSK |
0.657 | -0.116 | 1 | 0.626 |
ERBB4 |
0.657 | -0.075 | 1 | 0.679 |
FES |
0.656 | -0.063 | -1 | 0.675 |
ZAP70 |
0.653 | -0.026 | -1 | 0.622 |