Motif 381 (n=178)

Position-wise Probabilities

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uniprot genes site source protein function
A0AVK6 E2F8 S416 ochoa Transcription factor E2F8 (E2F-8) Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}.
A1A4S6 ARHGAP10 S642 ochoa Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}.
A3KN83 SBNO1 S692 ochoa Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250|UniProtKB:Q689Z5}.
A6NF01 POM121B S22 ochoa Putative nuclear envelope pore membrane protein POM 121B Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}.
A6NKT7 RGPD3 S1586 ochoa RanBP2-like and GRIP domain-containing protein 3 None
A8CG34 POM121C S415 ochoa Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
B8ZZF3 None S239 ochoa Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}.
E9PCH4 None S1286 ochoa Rap guanine nucleotide exchange factor 6 None
O14607 UTY S764 ochoa Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}.
O14715 RGPD8 S1585 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O15550 KDM6A S817 ochoa Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17761849, PubMed:17851529). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17713478, PubMed:17761849, PubMed:17851529). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}.
O43294 TGFB1I1 S140 ochoa Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
O43301 HSPA12A S22 ochoa Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A) Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. {ECO:0000269|PubMed:30679749}.
O60333 KIF1B S1658 ochoa Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}.
O60343 TBC1D4 S695 ochoa TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}.
O75179 ANKRD17 S1699 ochoa Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.
O75385 ULK1 S410 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75417 POLQ S1878 ochoa DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)] Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890). {ECO:0000250|UniProtKB:Q8CGS6, ECO:0000269|PubMed:14576298, ECO:0000269|PubMed:18503084, ECO:0000269|PubMed:19188258, ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:22135286, ECO:0000269|PubMed:24648516, ECO:0000269|PubMed:25642963, ECO:0000269|PubMed:25643323, ECO:0000269|PubMed:25775267, ECO:0000269|PubMed:26636256, ECO:0000269|PubMed:27311885, ECO:0000269|PubMed:27591252, ECO:0000269|PubMed:28695890, ECO:0000269|PubMed:30655289, ECO:0000269|PubMed:31562312, ECO:0000269|PubMed:32234782, ECO:0000269|PubMed:32873648, ECO:0000269|PubMed:34117057, ECO:0000269|PubMed:34140467, ECO:0000269|PubMed:34179826, ECO:0000269|PubMed:36455556, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080}.
O75626 PRDM1 S341 ochoa PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:Q60636, ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}.
O94818 NOL4 S239 ochoa Nucleolar protein 4 (Nucleolar-localized protein) None
O94915 FRYL S1483 ochoa Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}.
O94972 TRIM37 S800 ochoa E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}.
O95402 MED26 S231 ochoa Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
O95810 CAVIN2 S287 ochoa Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}.
P08235 NR3C2 S262 ochoa Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}.
P0DMU7 CT45A6 S114 ochoa Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) None
P0DMU8 CT45A5 S114 ochoa Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) None
P0DMV0 CT45A7 S114 ochoa Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) None
P15924 DSP S2584 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P22681 CBL S619 ochoa|psp E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}.
P28827 PTPRM S820 ochoa Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). {ECO:0000269|PubMed:10753936, ECO:0000269|PubMed:16456543, ECO:0000269|PubMed:17761881, ECO:0000269|PubMed:21998202}.
P29474 NOS3 S56 ochoa Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
P30414 NKTR S509 ochoa NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.
P35498 SCN1A S550 ochoa Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:14672992). By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits (By similarity). Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (By similarity). {ECO:0000250|UniProtKB:A2APX8, ECO:0000269|PubMed:14672992}.
P39880 CUX1 S875 ochoa Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
P42684 ABL2 S202 ochoa Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.
P42695 NCAPD3 S520 ochoa Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}.
P46019 PHKA2 S978 ochoa Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
P46019 PHKA2 S1043 ochoa Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
P46100 ATRX S1995 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P49585 PCYT1A S322 ochoa Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}.
P49792 RANBP2 S1764 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2561 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50616 TOB1 S151 ochoa Protein Tob1 (Transducer of erbB-2 1) Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}.
P57768 SNX16 S69 ochoa Sorting nexin-16 May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}.
P98082 DAB2 S422 ochoa Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.
Q06945 SOX4 S347 ochoa Transcription factor SOX-4 Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}.
Q08050 FOXM1 S692 ochoa Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.
Q12830 BPTF S201 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q12888 TP53BP1 S1316 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13129 RLF S1272 ochoa Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) May be involved in transcriptional regulation.
Q13136 PPFIA1 S1171 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q13163 MAP2K5 S132 ochoa Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). {ECO:0000250|UniProtKB:Q62862, ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}.
Q13233 MAP3K1 S506 ochoa Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}.
Q13495 MAMLD1 S529 ochoa Mastermind-like domain-containing protein 1 (F18) (Protein CG1) Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}.
Q13835 PKP1 S232 ochoa Plakophilin-1 (Band 6 protein) (B6P) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}.
Q14004 CDK13 S388 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14207 NPAT S774 ochoa Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.
Q14938 NFIX S380 ochoa Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Q15047 SETDB1 S504 ochoa Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}.
Q15047 SETDB1 S919 ochoa Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}.
Q15648 MED1 S1137 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15652 JMJD1C S638 ochoa Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.
Q3MIN7 RGL3 S558 ochoa Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}.
Q4VC05 BCL7A S113 ochoa B-cell CLL/lymphoma 7 protein family member A None
Q5HYN5 CT45A1 S114 ochoa Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) None
Q5R3F8 ELFN2 S757 ochoa Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.
Q5SNT2 TMEM201 S500 ochoa Transmembrane protein 201 (Spindle-associated membrane protein 1) Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.
Q5T200 ZC3H13 S241 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5T200 ZC3H13 S1278 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5TAQ9 DCAF8 S21 ochoa DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.
Q5U5Q3 MEX3C S540 ochoa RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.
Q5U5R9 HECTD2 S77 ochoa Probable E3 ubiquitin-protein ligase HECTD2 (EC 2.3.2.26) (HECT domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECTD2) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:28584101}.; FUNCTION: (Microbial infection) Catalyzes ubiquitination of Botulinum neurotoxin A light chain (LC) of C.botulinum neurotoxin type A (BoNT/A). {ECO:0000269|PubMed:28584101}.
Q684P5 RAP1GAP2 S612 ochoa Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}.
Q6DN14 MCTP1 S168 ochoa Multiple C2 and transmembrane domain-containing protein 1 Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250|UniProtKB:A1ZBD6}.
Q6K0P9 PYHIN1 S463 ochoa Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X) Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}.
Q6P0Q8 MAST2 S1298 ochoa Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6P5Q4 LMOD2 S515 ochoa Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin) Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:25250574, PubMed:26370058, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713). {ECO:0000250|UniProtKB:Q3UHZ5, ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:25250574, ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:26417072}.
Q6PGQ7 BORA S273 ochoa Protein aurora borealis (HsBora) Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}.
Q6ZWB6 KCTD8 S77 ochoa BTB/POZ domain-containing protein KCTD8 Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
Q70CQ4 USP31 S1088 ochoa Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}.
Q7LBC6 KDM3B S726 ochoa Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.
Q7Z3J3 RGPD4 S1586 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z3U7 MON2 S297 ochoa Protein MON2 homolog (Protein SF21) Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.
Q7Z4S6 KIF21A S1274 ochoa Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}.
Q7Z5J4 RAI1 S1107 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q86SQ0 PHLDB2 S203 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86UZ6 ZBTB46 S293 ochoa Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) Functions as a transcriptional repressor for PRDM1. {ECO:0000250}.
Q86VM9 ZC3H18 S604 ochoa Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) None
Q86VQ1 GLCCI1 S397 ochoa Glucocorticoid-induced transcript 1 protein None
Q86X10 RALGAPB S420 ochoa Ral GTPase-activating protein subunit beta (p170) Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q86XJ1 GAS2L3 S417 ochoa GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}.
Q86XZ4 SPATS2 S123 ochoa Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) None
Q86XZ4 SPATS2 S385 ochoa Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) None
Q8IVL0 NAV3 S1189 ochoa Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}.
Q8IVL1 NAV2 S1483 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IWB9 TEX2 S161 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8IWB9 TEX2 S165 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8IWZ3 ANKHD1 S1669 ochoa Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.
Q8N4X5 AFAP1L2 S558 ochoa Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}.
Q8N5G2 MACO1 S331 ochoa Macoilin (Macoilin-1) (Transmembrane protein 57) Plays a role in the regulation of neuronal activity. {ECO:0000269|PubMed:21589894}.
Q8N8V4 ANKS4B S183 ochoa Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp) As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q8K3X6, ECO:0000269|PubMed:26812018}.
Q8N8V4 ANKS4B S189 ochoa Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp) As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q8K3X6, ECO:0000269|PubMed:26812018}.
Q8NCE2 MTMR14 S529 ochoa Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}.
Q8NDV7 TNRC6A S1941 ochoa Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}.
Q8NEY1 NAV1 S1252 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NHU0 CT45A3 S114 ochoa Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) None
Q8TEU7 RAPGEF6 S1236 ochoa Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}.
Q8WUI4 HDAC7 S210 ochoa Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}.
Q8WVR3 TRAPPC14 S494 ochoa Trafficking protein particle complex subunit 14 (Microtubule-associated protein 11) Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:30715179, PubMed:31467083). TRAPP II complex also has GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097). {ECO:0000250|UniProtKB:Q3TLI0, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}.
Q8WX93 PALLD S754 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WXH0 SYNE2 S165 ochoa Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}.
Q92560 BAP1 S482 ochoa Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}.
Q92610 ZNF592 S145 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q92610 ZNF592 S367 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q96AY4 TTC28 S2334 ochoa Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}.
Q96BY7 ATG2B S1582 ochoa Autophagy-related protein 2 homolog B Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}.
Q96EP0 RNF31 S436 ochoa E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}.
Q96HA1 POM121 S438 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96IF1 AJUBA S136 ochoa LIM domain-containing protein ajuba Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}.
Q96JE7 SEC16B S947 ochoa Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21768384, ECO:0000303|PubMed:22355596}.
Q96JH7 VCPIP1 S997 ochoa Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}.
Q96PN7 TRERF1 S1069 ochoa Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.
Q96R06 SPAG5 S65 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q99081 TCF12 S304 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99666 RGPD5 S1585 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9BQE9 BCL7B S111 ochoa B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}.
Q9BRD0 BUD13 S357 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BTC0 DIDO1 S1018 ochoa Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.
Q9BVV6 KIAA0586 S1066 ochoa Protein TALPID3 Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}.
Q9BZB8 CPEB1 S181 ochoa Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1) Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195). {ECO:0000250|UniProtKB:P70166, ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195}.
Q9BZH6 WDR11 S204 ochoa WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). {ECO:0000269|PubMed:29263200, ECO:0000269|PubMed:29426865}.
Q9BZH6 WDR11 S208 ochoa WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). {ECO:0000269|PubMed:29263200, ECO:0000269|PubMed:29426865}.
Q9C0C2 TNKS1BP1 S274 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0D5 TANC1 S213 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9C0D5 TANC1 S303 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H1B7 IRF2BPL S658 ochoa Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}.
Q9H2D6 TRIOBP S881 ochoa TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.
Q9H2S9 IKZF4 S88 ochoa Zinc finger protein Eos (Ikaros family zinc finger protein 4) DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}.
Q9H2U2 PPA2 S316 ochoa Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2) Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598). {ECO:0000269|PubMed:27523597, ECO:0000269|PubMed:27523598}.
Q9H7P9 PLEKHG2 S1317 ochoa Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.
Q9HCE3 ZNF532 S297 ochoa Zinc finger protein 532 May be involved in transcriptional regulation.
Q9HCK8 CHD8 S431 ochoa Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}.
Q9NPI6 DCP1A S179 ochoa mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}.
Q9NR48 ASH1L S1747 ochoa Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}.
Q9NYL2 MAP3K20 S690 ochoa Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.
Q9P1Y5 CAMSAP3 S1099 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9P2B4 CTTNBP2NL S443 ochoa CTTNBP2 N-terminal-like protein Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}.
Q9P2E9 RRBP1 S1276 ochoa Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9UBW7 ZMYM2 S623 ochoa Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) Involved in the negative regulation of transcription. {ECO:0000269|PubMed:32891193}.
Q9UDT6 CLIP2 S30 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UKF7 PITPNC1 S273 ochoa Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}.
Q9UKJ3 GPATCH8 S352 ochoa G patch domain-containing protein 8 None
Q9UKV3 ACIN1 S481 ochoa Apoptotic chromatin condensation inducer in the nucleus (Acinus) Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.
Q9UKX7 NUP50 S314 ochoa Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}.
Q9ULH0 KIDINS220 S1410 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9ULH0 KIDINS220 S1593 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9ULJ7 ANKRD50 S1162 ochoa Ankyrin repeat domain-containing protein 50 Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Q9ULK2 ATXN7L1 S842 ochoa Ataxin-7-like protein 1 (Ataxin-7-like protein 4) None
Q9ULM3 YEATS2 S123 ochoa YEATS domain-containing protein 2 Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.
Q9ULM3 YEATS2 S468 ochoa YEATS domain-containing protein 2 Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.
Q9UMD9 COL17A1 S117 ochoa Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Q9UPN9 TRIM33 S808 ochoa E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.
Q9UPT8 ZC3H4 S907 ochoa Zinc finger CCCH domain-containing protein 4 RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}.
Q9UPU5 USP24 S2072 ochoa Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}.
Q9UPW6 SATB2 S453 ochoa DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}.
Q9UQ35 SRRM2 S934 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQC2 GAB2 S140 ochoa GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9UQQ2 SH2B3 S329 ochoa SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.
Q9Y253 POLH S550 ochoa DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}.
Q9Y3M8 STARD13 S333 ochoa StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}.
Q9Y3R5 DOP1B S717 ochoa Protein DOP1B May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.
Q9Y4F3 MARF1 S715 ochoa Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}.
Q9Y4F5 CEP170B S511 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Q9Y4G8 RAPGEF2 S1115 ochoa Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}.
Q9Y4J8 DTNA S563 ochoa Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Q9Y6R4 MAP3K4 S1251 ochoa Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
Q9Y6X8 ZHX2 S625 ochoa Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}.
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reactome_id name p -log10_p
R-HSA-9827857 Specification of primordial germ cells 0.000124 3.906
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.000789 3.103
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.000872 3.059
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.000872 3.059
R-HSA-1855170 IPs transport between nucleus and cytosol 0.001058 2.975
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.001058 2.975
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.001161 2.935
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.001387 2.858
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.001928 2.715
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.002083 2.681
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.002343 2.630
R-HSA-6804754 Regulation of TP53 Expression 0.000976 3.011
R-HSA-5578749 Transcriptional regulation by small RNAs 0.002251 2.648
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.001642 2.785
R-HSA-9706369 Negative regulation of FLT3 0.001579 2.802
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.001161 2.935
R-HSA-9607240 FLT3 Signaling 0.002246 2.649
R-HSA-180746 Nuclear import of Rev protein 0.001271 2.896
R-HSA-177243 Interactions of Rev with host cellular proteins 0.002083 2.681
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.002083 2.681
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.002246 2.649
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.001781 2.749
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.001928 2.715
R-HSA-383280 Nuclear Receptor transcription pathway 0.003062 2.514
R-HSA-71737 Pyrophosphate hydrolysis 0.002923 2.534
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.003198 2.495
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.003416 2.466
R-HSA-350054 Notch-HLH transcription pathway 0.004058 2.392
R-HSA-3214842 HDMs demethylate histones 0.005374 2.270
R-HSA-1474165 Reproduction 0.006506 2.187
R-HSA-2980766 Nuclear Envelope Breakdown 0.006524 2.186
R-HSA-191859 snRNP Assembly 0.007239 2.140
R-HSA-194441 Metabolism of non-coding RNA 0.007239 2.140
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.007009 2.154
R-HSA-168325 Viral Messenger RNA Synthesis 0.008004 2.097
R-HSA-6784531 tRNA processing in the nucleus 0.008406 2.075
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.009350 2.029
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.009433 2.025
R-HSA-1839124 FGFR1 mutant receptor activation 0.010026 1.999
R-HSA-211000 Gene Silencing by RNA 0.011586 1.936
R-HSA-4839726 Chromatin organization 0.011687 1.932
R-HSA-9682385 FLT3 signaling in disease 0.013009 1.886
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.013715 1.863
R-HSA-1169408 ISG15 antiviral mechanism 0.014865 1.828
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.016022 1.795
R-HSA-1433559 Regulation of KIT signaling 0.017831 1.749
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.017831 1.749
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.017831 1.749
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.019359 1.713
R-HSA-5655302 Signaling by FGFR1 in disease 0.018338 1.737
R-HSA-68875 Mitotic Prophase 0.018375 1.736
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.019723 1.705
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.019723 1.705
R-HSA-3371556 Cellular response to heat stress 0.018903 1.723
R-HSA-1433557 Signaling by SCF-KIT 0.020345 1.692
R-HSA-9673013 Diseases of Telomere Maintenance 0.022231 1.653
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.022231 1.653
R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.022231 1.653
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.022231 1.653
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.022231 1.653
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.022231 1.653
R-HSA-75153 Apoptotic execution phase 0.023574 1.628
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.027065 1.568
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.032691 1.486
R-HSA-70171 Glycolysis 0.037487 1.426
R-HSA-9839394 TGFBR3 expression 0.048133 1.318
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.042076 1.376
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.042076 1.376
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.042076 1.376
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.042076 1.376
R-HSA-198765 Signalling to ERK5 0.043970 1.357
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.042076 1.376
R-HSA-9932444 ATP-dependent chromatin remodelers 0.048133 1.318
R-HSA-9932451 SWI/SNF chromatin remodelers 0.048133 1.318
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.050921 1.293
R-HSA-1483249 Inositol phosphate metabolism 0.052330 1.281
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.053374 1.273
R-HSA-445095 Interaction between L1 and Ankyrins 0.053765 1.270
R-HSA-5576892 Phase 0 - rapid depolarisation 0.056664 1.247
R-HSA-74160 Gene expression (Transcription) 0.057889 1.237
R-HSA-1980143 Signaling by NOTCH1 0.069845 1.156
R-HSA-1226099 Signaling by FGFR in disease 0.066010 1.180
R-HSA-3247509 Chromatin modifying enzymes 0.068458 1.165
R-HSA-162909 Host Interactions of HIV factors 0.071400 1.146
R-HSA-70326 Glucose metabolism 0.061471 1.211
R-HSA-9930044 Nuclear RNA decay 0.071932 1.143
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.071932 1.143
R-HSA-203754 NOSIP mediated eNOS trafficking 0.075681 1.121
R-HSA-9706377 FLT3 signaling by CBL mutants 0.075681 1.121
R-HSA-9645135 STAT5 Activation 0.096238 1.017
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.106346 0.973
R-HSA-203641 NOSTRIN mediated eNOS trafficking 0.106346 0.973
R-HSA-196025 Formation of annular gap junctions 0.116341 0.934
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.116341 0.934
R-HSA-170984 ARMS-mediated activation 0.126225 0.899
R-HSA-190873 Gap junction degradation 0.126225 0.899
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.145664 0.837
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.164673 0.783
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.192400 0.716
R-HSA-110320 Translesion Synthesis by POLH 0.236594 0.626
R-HSA-912631 Regulation of signaling by CBL 0.236594 0.626
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.245139 0.611
R-HSA-8943723 Regulation of PTEN mRNA translation 0.278381 0.555
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.178269 0.749
R-HSA-390522 Striated Muscle Contraction 0.362477 0.441
R-HSA-182971 EGFR downregulation 0.340560 0.468
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.333089 0.477
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.253590 0.596
R-HSA-446107 Type I hemidesmosome assembly 0.116341 0.934
R-HSA-156711 Polo-like kinase mediated events 0.227952 0.642
R-HSA-203615 eNOS activation 0.369621 0.432
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.209366 0.679
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.209366 0.679
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.209366 0.679
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.164673 0.783
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.075681 1.121
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.183261 0.737
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.276816 0.558
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.192400 0.716
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.310167 0.508
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.302353 0.519
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.102202 0.991
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.338590 0.470
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.078371 1.106
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.227952 0.642
R-HSA-73980 RNA Polymerase III Transcription Termination 0.227952 0.642
R-HSA-912526 Interleukin receptor SHC signaling 0.278381 0.555
R-HSA-933542 TRAF6 mediated NF-kB activation 0.286461 0.543
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.369621 0.432
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.130045 0.886
R-HSA-6807070 PTEN Regulation 0.256629 0.591
R-HSA-9842860 Regulation of endogenous retroelements 0.135482 0.868
R-HSA-5656169 Termination of translesion DNA synthesis 0.325533 0.487
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.309894 0.509
R-HSA-392517 Rap1 signalling 0.236594 0.626
R-HSA-6807004 Negative regulation of MET activity 0.245139 0.611
R-HSA-1980145 Signaling by NOTCH2 0.369621 0.432
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.270210 0.568
R-HSA-9675126 Diseases of mitotic cell cycle 0.347947 0.458
R-HSA-157118 Signaling by NOTCH 0.335250 0.475
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.261946 0.582
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.174019 0.759
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.286461 0.543
R-HSA-5357905 Regulation of TNFR1 signaling 0.123982 0.907
R-HSA-9754189 Germ layer formation at gastrulation 0.236594 0.626
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.340560 0.468
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.317893 0.498
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.325533 0.487
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.369621 0.432
R-HSA-212165 Epigenetic regulation of gene expression 0.093921 1.027
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.210375 0.677
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.253590 0.596
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.253590 0.596
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.286461 0.543
R-HSA-1221632 Meiotic synapsis 0.150625 0.822
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.355253 0.449
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.231260 0.636
R-HSA-75893 TNF signaling 0.162368 0.789
R-HSA-169893 Prolonged ERK activation events 0.201438 0.696
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.174270 0.759
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.302353 0.519
R-HSA-8934903 Receptor Mediated Mitophagy 0.135999 0.866
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 0.210375 0.677
R-HSA-1295596 Spry regulation of FGF signaling 0.192400 0.716
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.109338 0.961
R-HSA-9839373 Signaling by TGFBR3 0.123982 0.907
R-HSA-444821 Relaxin receptors 0.086017 1.065
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.116341 0.934
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.192400 0.716
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.201438 0.696
R-HSA-429947 Deadenylation of mRNA 0.286461 0.543
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.302353 0.519
R-HSA-5693606 DNA Double Strand Break Response 0.206611 0.685
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.201438 0.696
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.088352 1.054
R-HSA-9022692 Regulation of MECP2 expression and activity 0.355253 0.449
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.095203 1.021
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.253590 0.596
R-HSA-429914 Deadenylation-dependent mRNA decay 0.174270 0.759
R-HSA-8943724 Regulation of PTEN gene transcription 0.178269 0.749
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.355253 0.449
R-HSA-5693532 DNA Double-Strand Break Repair 0.128094 0.892
R-HSA-9768759 Regulation of NPAS4 gene expression 0.219212 0.659
R-HSA-3214841 PKMTs methylate histone lysines 0.102202 0.991
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.338590 0.470
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.120277 0.920
R-HSA-73887 Death Receptor Signaling 0.305178 0.515
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.192400 0.716
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.201438 0.696
R-HSA-9609690 HCMV Early Events 0.223931 0.650
R-HSA-199991 Membrane Trafficking 0.339296 0.469
R-HSA-8953854 Metabolism of RNA 0.368395 0.434
R-HSA-9659379 Sensory processing of sound 0.256086 0.592
R-HSA-2559580 Oxidative Stress Induced Senescence 0.362899 0.440
R-HSA-525793 Myogenesis 0.302353 0.519
R-HSA-983189 Kinesins 0.178269 0.749
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.325533 0.487
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 0.325533 0.487
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.210701 0.676
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.132007 0.879
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.081657 1.088
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.253590 0.596
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.253590 0.596
R-HSA-9609646 HCMV Infection 0.360634 0.443
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.106346 0.973
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.162368 0.789
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 0.333089 0.477
R-HSA-1500620 Meiosis 0.280960 0.551
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.355253 0.449
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.166319 0.779
R-HSA-8983432 Interleukin-15 signaling 0.164673 0.783
R-HSA-69278 Cell Cycle, Mitotic 0.340491 0.468
R-HSA-1640170 Cell Cycle 0.121383 0.916
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.095203 1.021
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.333089 0.477
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.082126 1.086
R-HSA-5693538 Homology Directed Repair 0.186539 0.729
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.200731 0.697
R-HSA-9610379 HCMV Late Events 0.135970 0.867
R-HSA-1643713 Signaling by EGFR in Cancer 0.302353 0.519
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.325533 0.487
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.369621 0.432
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.175869 0.755
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.218084 0.661
R-HSA-5205647 Mitophagy 0.369621 0.432
R-HSA-168255 Influenza Infection 0.184738 0.733
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.285143 0.545
R-HSA-9707616 Heme signaling 0.186307 0.730
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.366286 0.436
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.366286 0.436
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.347947 0.458
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.270210 0.568
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.178269 0.749
R-HSA-9006936 Signaling by TGFB family members 0.142004 0.848
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.151047 0.821
R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.294452 0.531
R-HSA-9856651 MITF-M-dependent gene expression 0.292973 0.533
R-HSA-9700206 Signaling by ALK in cancer 0.151047 0.821
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.219212 0.659
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.219212 0.659
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.369621 0.432
R-HSA-166520 Signaling by NTRKs 0.286883 0.542
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.218905 0.660
R-HSA-1059683 Interleukin-6 signaling 0.174019 0.759
R-HSA-201556 Signaling by ALK 0.095203 1.021
R-HSA-379724 tRNA Aminoacylation 0.178269 0.749
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.107489 0.969
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.317893 0.498
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.342662 0.465
R-HSA-109581 Apoptosis 0.146085 0.835
R-HSA-162906 HIV Infection 0.302407 0.519
R-HSA-9705683 SARS-CoV-2-host interactions 0.304922 0.516
R-HSA-6783589 Interleukin-6 family signaling 0.286461 0.543
R-HSA-5357801 Programmed Cell Death 0.247928 0.606
R-HSA-162599 Late Phase of HIV Life Cycle 0.107489 0.969
R-HSA-72306 tRNA processing 0.164998 0.783
R-HSA-162587 HIV Life Cycle 0.135970 0.867
R-HSA-5619102 SLC transporter disorders 0.156484 0.806
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.130045 0.886
R-HSA-5619115 Disorders of transmembrane transporters 0.353015 0.452
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.370930 0.431
R-HSA-5688426 Deubiquitination 0.373326 0.428
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.374931 0.426
R-HSA-5619507 Activation of HOX genes during differentiation 0.374931 0.426
R-HSA-9833110 RSV-host interactions 0.374931 0.426
R-HSA-169911 Regulation of Apoptosis 0.376685 0.424
R-HSA-187687 Signalling to ERKs 0.376685 0.424
R-HSA-2559585 Oncogene Induced Senescence 0.376685 0.424
R-HSA-8853659 RET signaling 0.383670 0.416
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.383670 0.416
R-HSA-74158 RNA Polymerase III Transcription 0.383670 0.416
R-HSA-8941326 RUNX2 regulates bone development 0.383670 0.416
R-HSA-5689896 Ovarian tumor domain proteases 0.390577 0.408
R-HSA-8948216 Collagen chain trimerization 0.390577 0.408
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 0.397408 0.401
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.404162 0.393
R-HSA-8953750 Transcriptional Regulation by E2F6 0.404162 0.393
R-HSA-69275 G2/M Transition 0.405597 0.392
R-HSA-212436 Generic Transcription Pathway 0.406247 0.391
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.410442 0.387
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.410841 0.386
R-HSA-451927 Interleukin-2 family signaling 0.410841 0.386
R-HSA-379726 Mitochondrial tRNA aminoacylation 0.410841 0.386
R-HSA-8982491 Glycogen metabolism 0.410841 0.386
R-HSA-453274 Mitotic G2-G2/M phases 0.411588 0.386
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.414328 0.383
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.417445 0.379
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.417445 0.379
R-HSA-8853884 Transcriptional Regulation by VENTX 0.417445 0.379
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 0.417445 0.379
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.417445 0.379
R-HSA-6811438 Intra-Golgi traffic 0.423976 0.373
R-HSA-73894 DNA Repair 0.424623 0.372
R-HSA-72163 mRNA Splicing - Major Pathway 0.429447 0.367
R-HSA-373760 L1CAM interactions 0.429745 0.367
R-HSA-110329 Cleavage of the damaged pyrimidine 0.430434 0.366
R-HSA-73928 Depyrimidination 0.430434 0.366
R-HSA-379716 Cytosolic tRNA aminoacylation 0.430434 0.366
R-HSA-446728 Cell junction organization 0.431300 0.365
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.435359 0.361
R-HSA-5654743 Signaling by FGFR4 0.436821 0.360
R-HSA-8854214 TBC/RABGAPs 0.436821 0.360
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.436821 0.360
R-HSA-190828 Gap junction trafficking 0.443135 0.353
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.447113 0.350
R-HSA-5654741 Signaling by FGFR3 0.449380 0.347
R-HSA-2299718 Condensation of Prophase Chromosomes 0.455555 0.341
R-HSA-6809371 Formation of the cornified envelope 0.459922 0.337
R-HSA-1483191 Synthesis of PC 0.461661 0.336
R-HSA-72172 mRNA Splicing 0.461669 0.336
R-HSA-3700989 Transcriptional Regulation by TP53 0.465895 0.332
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.467698 0.330
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.467698 0.330
R-HSA-9031628 NGF-stimulated transcription 0.467698 0.330
R-HSA-1257604 PIP3 activates AKT signaling 0.473256 0.325
R-HSA-73893 DNA Damage Bypass 0.473669 0.325
R-HSA-157858 Gap junction trafficking and regulation 0.473669 0.325
R-HSA-68886 M Phase 0.474807 0.323
R-HSA-109704 PI3K Cascade 0.479573 0.319
R-HSA-397014 Muscle contraction 0.484610 0.315
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.485411 0.314
R-HSA-9730414 MITF-M-regulated melanocyte development 0.487445 0.312
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.491184 0.309
R-HSA-9843745 Adipogenesis 0.492743 0.307
R-HSA-5576891 Cardiac conduction 0.492743 0.307
R-HSA-8856688 Golgi-to-ER retrograde transport 0.496313 0.304
R-HSA-9909396 Circadian clock 0.496313 0.304
R-HSA-418990 Adherens junctions interactions 0.501509 0.300
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.502537 0.299
R-HSA-9012852 Signaling by NOTCH3 0.508119 0.294
R-HSA-177929 Signaling by EGFR 0.513638 0.289
R-HSA-193648 NRAGE signals death through JNK 0.513638 0.289
R-HSA-5654736 Signaling by FGFR1 0.513638 0.289
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.513638 0.289
R-HSA-9018519 Estrogen-dependent gene expression 0.513919 0.289
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.517391 0.286
R-HSA-112399 IRS-mediated signalling 0.519096 0.285
R-HSA-1500931 Cell-Cell communication 0.523418 0.281
R-HSA-8878171 Transcriptional regulation by RUNX1 0.523598 0.281
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.524493 0.280
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.529830 0.276
R-HSA-186712 Regulation of beta-cell development 0.529830 0.276
R-HSA-1632852 Macroautophagy 0.531117 0.275
R-HSA-2428928 IRS-related events triggered by IGF1R 0.540325 0.267
R-HSA-9793380 Formation of paraxial mesoderm 0.540325 0.267
R-HSA-1442490 Collagen degradation 0.540325 0.267
R-HSA-8856828 Clathrin-mediated endocytosis 0.541237 0.267
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.545485 0.263
R-HSA-162582 Signal Transduction 0.550483 0.259
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.550588 0.259
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.550588 0.259
R-HSA-8848021 Signaling by PTK6 0.550588 0.259
R-HSA-8939211 ESR-mediated signaling 0.553082 0.257
R-HSA-2428924 IGF1R signaling cascade 0.555633 0.255
R-HSA-74751 Insulin receptor signalling cascade 0.555633 0.255
R-HSA-1234174 Cellular response to hypoxia 0.560622 0.251
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.560622 0.251
R-HSA-9758941 Gastrulation 0.561022 0.251
R-HSA-73857 RNA Polymerase II Transcription 0.562064 0.250
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.570434 0.244
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.575258 0.240
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.575258 0.240
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.575258 0.240
R-HSA-1989781 PPARA activates gene expression 0.580195 0.236
R-HSA-9006925 Intracellular signaling by second messengers 0.582214 0.235
R-HSA-9612973 Autophagy 0.583330 0.234
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.584745 0.233
R-HSA-204005 COPII-mediated vesicle transport 0.584745 0.233
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.586449 0.232
R-HSA-421270 Cell-cell junction organization 0.589013 0.230
R-HSA-8978934 Metabolism of cofactors 0.589409 0.230
R-HSA-5653656 Vesicle-mediated transport 0.589885 0.229
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.594020 0.226
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.594020 0.226
R-HSA-5633007 Regulation of TP53 Activity 0.595701 0.225
R-HSA-9694516 SARS-CoV-2 Infection 0.597326 0.224
R-HSA-4086398 Ca2+ pathway 0.598581 0.223
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.598581 0.223
R-HSA-9013694 Signaling by NOTCH4 0.603090 0.220
R-HSA-69473 G2/M DNA damage checkpoint 0.603090 0.220
R-HSA-1222556 ROS and RNS production in phagocytes 0.603090 0.220
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.607549 0.216
R-HSA-5689603 UCH proteinases 0.611959 0.213
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.616319 0.210
R-HSA-416482 G alpha (12/13) signalling events 0.620630 0.207
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.620630 0.207
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.621975 0.206
R-HSA-2262752 Cellular responses to stress 0.624397 0.205
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.624893 0.204
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.629108 0.201
R-HSA-5654738 Signaling by FGFR2 0.629108 0.201
R-HSA-6806834 Signaling by MET 0.629108 0.201
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.629108 0.201
R-HSA-5693607 Processing of DNA double-strand break ends 0.633277 0.198
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.633277 0.198
R-HSA-5689880 Ub-specific processing proteases 0.636832 0.196
R-HSA-9707564 Cytoprotection by HMOX1 0.641474 0.193
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.645504 0.190
R-HSA-5687128 MAPK6/MAPK4 signaling 0.649489 0.187
R-HSA-6794362 Protein-protein interactions at synapses 0.649489 0.187
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.653430 0.185
R-HSA-141424 Amplification of signal from the kinetochores 0.653430 0.185
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.653430 0.185
R-HSA-2559583 Cellular Senescence 0.656144 0.183
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.661755 0.179
R-HSA-201681 TCF dependent signaling in response to WNT 0.664168 0.178
R-HSA-9663891 Selective autophagy 0.664989 0.177
R-HSA-8953897 Cellular responses to stimuli 0.665454 0.177
R-HSA-913531 Interferon Signaling 0.667836 0.175
R-HSA-112310 Neurotransmitter release cycle 0.672481 0.172
R-HSA-73884 Base Excision Repair 0.672481 0.172
R-HSA-8986944 Transcriptional Regulation by MECP2 0.676164 0.170
R-HSA-74752 Signaling by Insulin receptor 0.683408 0.165
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.690490 0.161
R-HSA-1474290 Collagen formation 0.690490 0.161
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.693972 0.159
R-HSA-195721 Signaling by WNT 0.695499 0.158
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.700820 0.154
R-HSA-157579 Telomere Maintenance 0.704186 0.152
R-HSA-8878159 Transcriptional regulation by RUNX3 0.704186 0.152
R-HSA-190236 Signaling by FGFR 0.707515 0.150
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.707515 0.150
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.707515 0.150
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.707515 0.150
R-HSA-3214847 HATs acetylate histones 0.710806 0.148
R-HSA-193704 p75 NTR receptor-mediated signalling 0.710806 0.148
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.713873 0.146
R-HSA-69618 Mitotic Spindle Checkpoint 0.714061 0.146
R-HSA-9009391 Extra-nuclear estrogen signaling 0.717279 0.144
R-HSA-1483255 PI Metabolism 0.720461 0.142
R-HSA-6805567 Keratinization 0.723045 0.141
R-HSA-9860931 Response of endothelial cells to shear stress 0.726719 0.139
R-HSA-418346 Platelet homeostasis 0.735845 0.133
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.741760 0.130
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.741760 0.130
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.744669 0.128
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.744669 0.128
R-HSA-68882 Mitotic Anaphase 0.744900 0.128
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.747003 0.127
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.753199 0.123
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.753199 0.123
R-HSA-2871796 FCERI mediated MAPK activation 0.753199 0.123
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.755979 0.121
R-HSA-9855142 Cellular responses to mechanical stimuli 0.758727 0.120
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.764133 0.117
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.764133 0.117
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.766790 0.115
R-HSA-9007101 Rab regulation of trafficking 0.772016 0.112
R-HSA-1592230 Mitochondrial biogenesis 0.772016 0.112
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.774585 0.111
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.777126 0.110
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.777126 0.110
R-HSA-8878166 Transcriptional regulation by RUNX2 0.777126 0.110
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.782121 0.107
R-HSA-73886 Chromosome Maintenance 0.782121 0.107
R-HSA-5683057 MAPK family signaling cascades 0.783025 0.106
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.784577 0.105
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.784577 0.105
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.787005 0.104
R-HSA-9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 0.787005 0.104
R-HSA-1266738 Developmental Biology 0.791763 0.101
R-HSA-194138 Signaling by VEGF 0.794128 0.100
R-HSA-114608 Platelet degranulation 0.798744 0.098
R-HSA-69481 G2/M Checkpoints 0.798744 0.098
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.805477 0.094
R-HSA-9006931 Signaling by Nuclear Receptors 0.806728 0.093
R-HSA-9717189 Sensory perception of taste 0.809840 0.092
R-HSA-1474228 Degradation of the extracellular matrix 0.811985 0.090
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.814106 0.089
R-HSA-69620 Cell Cycle Checkpoints 0.821259 0.086
R-HSA-3858494 Beta-catenin independent WNT signaling 0.822354 0.085
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.834516 0.079
R-HSA-199977 ER to Golgi Anterograde Transport 0.844978 0.073
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.846729 0.072
R-HSA-597592 Post-translational protein modification 0.858225 0.066
R-HSA-5673001 RAF/MAP kinase cascade 0.863820 0.064
R-HSA-1483257 Phospholipid metabolism 0.870908 0.060
R-HSA-5684996 MAPK1/MAPK3 signaling 0.872055 0.059
R-HSA-2467813 Separation of Sister Chromatids 0.872208 0.059
R-HSA-422475 Axon guidance 0.882702 0.054
R-HSA-418555 G alpha (s) signalling events 0.883321 0.054
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.884640 0.053
R-HSA-9679506 SARS-CoV Infections 0.890740 0.050
R-HSA-109582 Hemostasis 0.893297 0.049
R-HSA-375276 Peptide ligand-binding receptors 0.901630 0.045
R-HSA-1474244 Extracellular matrix organization 0.906787 0.042
R-HSA-6798695 Neutrophil degranulation 0.906803 0.042
R-HSA-168898 Toll-like Receptor Cascades 0.907074 0.042
R-HSA-68877 Mitotic Prometaphase 0.909167 0.041
R-HSA-9675108 Nervous system development 0.910095 0.041
R-HSA-389948 Co-inhibition by PD-1 0.916130 0.038
R-HSA-948021 Transport to the Golgi and subsequent modification 0.918020 0.037
R-HSA-376176 Signaling by ROBO receptors 0.918949 0.037
R-HSA-1483206 Glycerophospholipid biosynthesis 0.918949 0.037
R-HSA-1280215 Cytokine Signaling in Immune system 0.930085 0.031
R-HSA-8951664 Neddylation 0.934738 0.029
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.940433 0.027
R-HSA-388841 Regulation of T cell activation by CD28 family 0.956246 0.019
R-HSA-9734767 Developmental Cell Lineages 0.959613 0.018
R-HSA-9711123 Cellular response to chemical stress 0.961859 0.017
R-HSA-72766 Translation 0.963300 0.016
R-HSA-76002 Platelet activation, signaling and aggregation 0.964390 0.016
R-HSA-1852241 Organelle biogenesis and maintenance 0.978986 0.009
R-HSA-112315 Transmission across Chemical Synapses 0.979698 0.009
R-HSA-8957322 Metabolism of steroids 0.979930 0.009
R-HSA-1280218 Adaptive Immune System 0.982468 0.008
R-HSA-196854 Metabolism of vitamins and cofactors 0.987330 0.006
R-HSA-9824446 Viral Infection Pathways 0.990583 0.004
R-HSA-9824439 Bacterial Infection Pathways 0.990718 0.004
R-HSA-392499 Metabolism of proteins 0.991062 0.004
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.991137 0.004
R-HSA-446203 Asparagine N-linked glycosylation 0.993585 0.003
R-HSA-449147 Signaling by Interleukins 0.994821 0.002
R-HSA-112316 Neuronal System 0.996234 0.002
R-HSA-168256 Immune System 0.996293 0.002
R-HSA-168249 Innate Immune System 0.998198 0.001
R-HSA-388396 GPCR downstream signalling 0.998911 0.000
R-HSA-500792 GPCR ligand binding 0.999079 0.000
R-HSA-372790 Signaling by GPCR 0.999552 0.000
R-HSA-5663205 Infectious disease 0.999745 0.000
R-HSA-1643685 Disease 0.999763 0.000
R-HSA-9709957 Sensory Perception 0.999946 0.000
R-HSA-556833 Metabolism of lipids 0.999977 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDC7CDC7 0.738 0.283 1 0.330
COTCOT 0.731 0.116 2 0.299
CK1ECK1E 0.729 0.272 -3 0.772
KISKIS 0.728 0.081 1 0.122
GRK1GRK1 0.728 0.185 -2 0.761
CLK3CLK3 0.727 0.104 1 0.203
BMPR1BBMPR1B 0.726 0.304 1 0.465
CK1DCK1D 0.720 0.276 -3 0.752
MOSMOS 0.720 0.162 1 0.252
CK1A2CK1A2 0.719 0.272 -3 0.752
CHAK2CHAK2 0.717 0.144 -1 0.824
HIPK4HIPK4 0.716 0.081 1 0.143
PIM3PIM3 0.716 0.057 -3 0.591
CK1ACK1A 0.715 0.292 -3 0.706
MTORMTOR 0.715 0.020 1 0.180
IKKBIKKB 0.715 0.024 -2 0.694
SKMLCKSKMLCK 0.714 0.100 -2 0.871
GRK7GRK7 0.714 0.164 1 0.289
GRK5GRK5 0.713 0.175 -3 0.689
GRK6GRK6 0.713 0.193 1 0.334
HIPK2HIPK2 0.713 0.038 1 0.110
CK1G1CK1G1 0.712 0.188 -3 0.740
NDR2NDR2 0.712 0.023 -3 0.588
GRK2GRK2 0.711 0.248 -2 0.663
CDK1CDK1 0.710 0.036 1 0.189
AURCAURC 0.709 0.085 -2 0.684
TBK1TBK1 0.709 -0.065 1 0.165
RSK2RSK2 0.709 0.044 -3 0.518
IKKAIKKA 0.708 0.039 -2 0.691
GRK3GRK3 0.708 0.226 -2 0.624
RAF1RAF1 0.708 0.033 1 0.234
BMPR1ABMPR1A 0.708 0.227 1 0.441
ACVR2BACVR2B 0.707 0.237 -2 0.714
IKKEIKKE 0.707 -0.064 1 0.167
ATRATR 0.707 0.012 1 0.191
CDK18CDK18 0.706 0.009 1 0.131
NLKNLK 0.706 -0.021 1 0.193
CDK19CDK19 0.706 -0.002 1 0.128
PRPKPRPK 0.705 -0.023 -1 0.833
PRKD1PRKD1 0.705 0.031 -3 0.539
CLK2CLK2 0.704 0.064 -3 0.522
CDK7CDK7 0.704 0.013 1 0.146
CDK8CDK8 0.704 -0.013 1 0.136
TGFBR1TGFBR1 0.703 0.143 -2 0.736
GRK4GRK4 0.703 0.077 -2 0.771
ACVR2AACVR2A 0.703 0.215 -2 0.701
ERK5ERK5 0.703 -0.033 1 0.180
MLK1MLK1 0.703 -0.023 2 0.269
MST4MST4 0.703 -0.005 2 0.355
RIPK3RIPK3 0.702 -0.022 3 0.712
DRAK1DRAK1 0.702 0.200 1 0.461
RSK4RSK4 0.702 0.056 -3 0.509
DSTYKDSTYK 0.702 -0.044 2 0.309
CAMK2GCAMK2G 0.702 -0.032 2 0.281
PRKD2PRKD2 0.702 0.030 -3 0.501
SRPK1SRPK1 0.702 0.004 -3 0.515
P38GP38G 0.702 -0.002 1 0.142
GCN2GCN2 0.702 -0.129 2 0.275
MAPKAPK2MAPKAPK2 0.702 0.030 -3 0.483
DYRK2DYRK2 0.701 -0.014 1 0.137
JNK2JNK2 0.701 -0.000 1 0.149
P90RSKP90RSK 0.701 0.009 -3 0.521
CDK17CDK17 0.700 -0.006 1 0.141
CAMK1BCAMK1B 0.700 -0.009 -3 0.598
TGFBR2TGFBR2 0.700 0.012 -2 0.723
DLKDLK 0.700 0.105 1 0.265
NDR1NDR1 0.700 -0.026 -3 0.574
PIM1PIM1 0.699 0.021 -3 0.560
MLK3MLK3 0.699 -0.013 2 0.249
DAPK2DAPK2 0.699 0.091 -3 0.601
CDKL1CDKL1 0.699 -0.007 -3 0.551
ICKICK 0.699 0.028 -3 0.575
PKN2PKN2 0.699 -0.028 -3 0.585
CDKL5CDKL5 0.699 -0.007 -3 0.538
FAM20CFAM20C 0.699 -0.022 2 0.210
PKACGPKACG 0.699 0.015 -2 0.728
CAMK2BCAMK2B 0.699 0.020 2 0.266
PAK1PAK1 0.699 0.003 -2 0.818
PDHK4PDHK4 0.698 -0.118 1 0.207
ALK4ALK4 0.698 0.143 -2 0.761
PRKXPRKX 0.698 0.074 -3 0.480
ULK2ULK2 0.698 -0.148 2 0.274
NEK6NEK6 0.697 -0.058 -2 0.787
ERK1ERK1 0.697 -0.004 1 0.126
PKN3PKN3 0.697 -0.066 -3 0.566
RSK3RSK3 0.697 -0.013 -3 0.507
BMPR2BMPR2 0.697 -0.014 -2 0.820
PKACBPKACB 0.697 0.053 -2 0.685
P38BP38B 0.697 0.012 1 0.137
CAMK2ACAMK2A 0.696 0.030 2 0.279
HIPK1HIPK1 0.696 0.014 1 0.134
MSK1MSK1 0.696 0.037 -3 0.509
TTBK2TTBK2 0.695 -0.080 2 0.227
MLK4MLK4 0.695 0.007 2 0.223
PKCDPKCD 0.695 -0.041 2 0.278
LATS2LATS2 0.695 -0.019 -5 0.724
CAMLCKCAMLCK 0.695 0.019 -2 0.842
NEK7NEK7 0.695 -0.100 -3 0.603
CDK13CDK13 0.695 -0.029 1 0.132
CK2A2CK2A2 0.694 0.139 1 0.417
CK2A1CK2A1 0.694 0.159 1 0.442
AURAAURA 0.694 0.062 -2 0.669
CDK5CDK5 0.694 -0.017 1 0.152
MLK2MLK2 0.694 -0.054 2 0.309
CDK3CDK3 0.694 -0.001 1 0.144
PKCBPKCB 0.694 -0.036 2 0.245
CAMK2DCAMK2D 0.693 -0.049 -3 0.567
JNK3JNK3 0.693 -0.018 1 0.141
WNK1WNK1 0.693 -0.085 -2 0.868
MAPKAPK3MAPKAPK3 0.693 -0.015 -3 0.510
PLK1PLK1 0.693 0.063 -2 0.734
CLK4CLK4 0.693 0.023 -3 0.541
AMPKA1AMPKA1 0.693 -0.006 -3 0.592
PKCGPKCG 0.693 -0.029 2 0.241
NIKNIK 0.693 -0.046 -3 0.616
ULK1ULK1 0.692 -0.128 -3 0.566
P70S6KBP70S6KB 0.692 -0.006 -3 0.542
MASTLMASTL 0.692 -0.074 -2 0.778
PAK3PAK3 0.692 -0.032 -2 0.805
DYRK4DYRK4 0.692 -0.020 1 0.128
HUNKHUNK 0.692 -0.089 2 0.274
MSK2MSK2 0.692 -0.010 -3 0.515
P38DP38D 0.692 0.003 1 0.088
NUAK2NUAK2 0.691 -0.028 -3 0.593
CDK12CDK12 0.691 -0.030 1 0.128
SRPK2SRPK2 0.691 -0.011 -3 0.460
AURBAURB 0.690 0.042 -2 0.680
CDK16CDK16 0.690 -0.010 1 0.131
MYLK4MYLK4 0.689 0.049 -2 0.782
CHAK1CHAK1 0.689 -0.018 2 0.355
PASKPASK 0.689 0.140 -3 0.617
PAK6PAK6 0.689 -0.011 -2 0.731
ALK2ALK2 0.689 0.092 -2 0.740
AMPKA2AMPKA2 0.689 -0.009 -3 0.561
CDK10CDK10 0.689 -0.005 1 0.146
P38AP38A 0.688 -0.007 1 0.143
CLK1CLK1 0.688 0.005 -3 0.503
RIPK1RIPK1 0.688 -0.088 1 0.185
PKCAPKCA 0.688 -0.041 2 0.256
MNK2MNK2 0.688 -0.031 -2 0.800
CDK14CDK14 0.688 -0.015 1 0.148
PDHK1PDHK1 0.688 -0.178 1 0.174
PAK2PAK2 0.687 -0.014 -2 0.799
ATMATM 0.687 -0.039 1 0.181
YSK4YSK4 0.687 -0.047 1 0.203
SMG1SMG1 0.687 -0.017 1 0.152
IRE1IRE1 0.687 -0.101 1 0.139
MNK1MNK1 0.686 -0.029 -2 0.797
DYRK1BDYRK1B 0.686 -0.009 1 0.142
NEK9NEK9 0.686 -0.131 2 0.303
PHKG1PHKG1 0.686 -0.074 -3 0.575
DYRK1ADYRK1A 0.686 -0.012 1 0.135
PKCZPKCZ 0.686 -0.058 2 0.281
CAMK4CAMK4 0.686 -0.052 -3 0.578
LATS1LATS1 0.685 0.015 -3 0.581
DNAPKDNAPK 0.685 -0.046 1 0.133
MARK4MARK4 0.685 -0.065 4 0.785
YANK3YANK3 0.685 0.055 2 0.130
PKG2PKG2 0.685 0.006 -2 0.671
BCKDKBCKDK 0.685 -0.126 -1 0.776
MST3MST3 0.685 0.058 2 0.322
BRSK1BRSK1 0.684 -0.018 -3 0.535
TLK2TLK2 0.684 -0.016 1 0.173
MEK1MEK1 0.684 0.058 2 0.313
PKCHPKCH 0.684 -0.065 2 0.227
ERK2ERK2 0.683 -0.040 1 0.141
SRPK3SRPK3 0.683 -0.022 -3 0.508
AKT2AKT2 0.683 0.001 -3 0.472
ANKRD3ANKRD3 0.682 -0.091 1 0.205
CDK9CDK9 0.682 -0.055 1 0.132
TSSK2TSSK2 0.681 -0.056 -5 0.804
HIPK3HIPK3 0.681 -0.023 1 0.110
NIM1NIM1 0.681 -0.108 3 0.727
WNK3WNK3 0.681 -0.201 1 0.160
PLK4PLK4 0.680 -0.103 2 0.190
PLK3PLK3 0.680 -0.052 2 0.245
CDK2CDK2 0.680 -0.026 1 0.221
MAKMAK 0.680 0.049 -2 0.867
PRKD3PRKD3 0.680 -0.035 -3 0.490
SGK3SGK3 0.679 -0.033 -3 0.517
TSSK1TSSK1 0.679 -0.064 -3 0.597
QSKQSK 0.679 -0.018 4 0.758
JNK1JNK1 0.679 -0.015 1 0.160
PKRPKR 0.678 -0.085 1 0.170
GSK3AGSK3A 0.678 0.060 4 0.547
PAK4PAK4 0.678 -0.006 -2 0.704
MEKK3MEKK3 0.678 0.005 1 0.231
DYRK3DYRK3 0.678 -0.018 1 0.125
TAO3TAO3 0.677 0.032 1 0.207
BRSK2BRSK2 0.677 -0.075 -3 0.551
PKACAPKACA 0.677 0.020 -2 0.632
PRP4PRP4 0.677 -0.025 -3 0.547
GSK3BGSK3B 0.676 0.058 4 0.541
DAPK1DAPK1 0.676 0.093 -3 0.559
IRE2IRE2 0.676 -0.125 2 0.251
PAK5PAK5 0.676 -0.011 -2 0.689
NEK2NEK2 0.676 -0.117 2 0.315
ERK7ERK7 0.676 -0.045 2 0.185
MELKMELK 0.676 -0.095 -3 0.538
MPSK1MPSK1 0.675 0.002 1 0.120
GCKGCK 0.675 0.106 1 0.268
PIM2PIM2 0.675 -0.009 -3 0.505
ZAKZAK 0.675 -0.069 1 0.202
VRK2VRK2 0.674 -0.149 1 0.179
DCAMKL1DCAMKL1 0.674 -0.057 -3 0.534
NUAK1NUAK1 0.673 -0.076 -3 0.531
NEK11NEK11 0.673 0.004 1 0.223
SIKSIK 0.672 -0.050 -3 0.524
MARK3MARK3 0.672 -0.020 4 0.710
SNRKSNRK 0.672 -0.135 2 0.218
TTBK1TTBK1 0.671 -0.105 2 0.194
QIKQIK 0.671 -0.095 -3 0.584
DAPK3DAPK3 0.671 0.055 -3 0.560
HPK1HPK1 0.671 0.076 1 0.260
PKCTPKCT 0.671 -0.082 2 0.240
MAPKAPK5MAPKAPK5 0.671 -0.082 -3 0.476
MEK5MEK5 0.671 -0.071 2 0.296
CAMK1GCAMK1G 0.670 -0.066 -3 0.518
MEKK2MEKK2 0.670 -0.057 2 0.274
PLK2PLK2 0.669 -0.004 -3 0.588
PKCEPKCE 0.669 -0.029 2 0.245
AKT1AKT1 0.669 -0.018 -3 0.481
MOKMOK 0.668 0.015 1 0.127
CK1G3CK1G3 0.668 0.190 -3 0.676
DCAMKL2DCAMKL2 0.668 -0.076 -3 0.544
MEKK1MEKK1 0.667 -0.127 1 0.162
GAKGAK 0.667 0.019 1 0.206
PKCIPKCI 0.666 -0.065 2 0.258
SMMLCKSMMLCK 0.666 -0.002 -3 0.558
NEK5NEK5 0.666 -0.108 1 0.162
IRAK4IRAK4 0.665 -0.140 1 0.126
CDK4CDK4 0.665 -0.047 1 0.120
CDK6CDK6 0.665 -0.047 1 0.119
P70S6KP70S6K 0.665 -0.044 -3 0.468
AKT3AKT3 0.664 -0.005 -3 0.422
BRAFBRAF 0.664 -0.072 -4 0.797
MARK2MARK2 0.664 -0.055 4 0.671
LKB1LKB1 0.664 0.020 -3 0.587
PERKPERK 0.664 -0.134 -2 0.751
STK33STK33 0.664 -0.072 2 0.203
TLK1TLK1 0.663 -0.072 -2 0.761
MARK1MARK1 0.663 -0.053 4 0.732
PHKG2PHKG2 0.663 -0.118 -3 0.542
KHS2KHS2 0.663 0.041 1 0.222
MAP3K15MAP3K15 0.662 -0.050 1 0.173
PINK1PINK1 0.662 -0.099 1 0.146
MINKMINK 0.662 0.000 1 0.196
SSTKSSTK 0.661 -0.081 4 0.743
WNK4WNK4 0.661 -0.148 -2 0.856
CHK1CHK1 0.661 -0.087 -3 0.543
SGK1SGK1 0.660 -0.005 -3 0.413
TAK1TAK1 0.660 0.004 1 0.216
MST2MST2 0.660 -0.027 1 0.231
YANK2YANK2 0.659 0.059 2 0.129
KHS1KHS1 0.659 0.002 1 0.187
CAMK1DCAMK1D 0.658 -0.044 -3 0.463
PDK1PDK1 0.658 -0.076 1 0.163
SLKSLK 0.658 -0.022 -2 0.671
NEK8NEK8 0.657 -0.105 2 0.288
PKN1PKN1 0.657 -0.079 -3 0.482
TAO2TAO2 0.657 -0.084 2 0.325
TNIKTNIK 0.657 -0.026 3 0.815
CAMKK1CAMKK1 0.656 -0.083 -2 0.704
ROCK2ROCK2 0.656 -0.004 -3 0.545
MEKK6MEKK6 0.656 -0.105 1 0.176
HGKHGK 0.656 -0.051 3 0.817
EEF2KEEF2K 0.655 -0.053 3 0.787
HRIHRI 0.655 -0.187 -2 0.768
CAMKK2CAMKK2 0.654 -0.048 -2 0.705
CK1G2CK1G2 0.654 0.171 -3 0.714
LOKLOK 0.654 -0.059 -2 0.726
CHK2CHK2 0.653 -0.032 -3 0.423
MRCKBMRCKB 0.653 -0.024 -3 0.499
MRCKAMRCKA 0.653 -0.012 -3 0.512
NEK4NEK4 0.653 -0.109 1 0.155
PBKPBK 0.652 -0.029 1 0.133
IRAK1IRAK1 0.652 -0.183 -1 0.758
BUB1BUB1 0.651 0.018 -5 0.729
VRK1VRK1 0.651 -0.101 2 0.288
OSR1OSR1 0.649 -0.002 2 0.304
MST1MST1 0.649 -0.057 1 0.206
LRRK2LRRK2 0.646 -0.112 2 0.314
NEK1NEK1 0.646 -0.126 1 0.150
YSK1YSK1 0.645 -0.105 2 0.301
TXKTXK 0.645 0.234 1 0.385
HASPINHASPIN 0.645 -0.030 -1 0.697
PKG1PKG1 0.645 -0.044 -2 0.592
TTKTTK 0.643 -0.004 -2 0.757
PDHK3_TYRPDHK3_TYR 0.643 0.173 4 0.882
DMPK1DMPK1 0.642 -0.004 -3 0.519
CAMK1ACAMK1A 0.641 -0.061 -3 0.426
CRIKCRIK 0.641 -0.010 -3 0.470
RIPK2RIPK2 0.641 -0.177 1 0.173
MEK2MEK2 0.640 -0.138 2 0.302
PDHK4_TYRPDHK4_TYR 0.640 0.160 2 0.340
ROCK1ROCK1 0.640 -0.032 -3 0.513
SBKSBK 0.638 -0.040 -3 0.368
MAP2K6_TYRMAP2K6_TYR 0.636 0.170 -1 0.840
ALPHAK3ALPHAK3 0.636 -0.001 -1 0.725
PDHK1_TYRPDHK1_TYR 0.636 0.159 -1 0.845
ASK1ASK1 0.634 -0.105 1 0.170
MYO3BMYO3B 0.634 -0.064 2 0.337
BMPR2_TYRBMPR2_TYR 0.633 0.141 -1 0.826
MYO3AMYO3A 0.632 -0.064 1 0.168
MAP2K4_TYRMAP2K4_TYR 0.632 0.121 -1 0.831
TESK1_TYRTESK1_TYR 0.632 0.031 3 0.830
TAO1TAO1 0.631 -0.101 1 0.142
NEK3NEK3 0.628 -0.179 1 0.110
BIKEBIKE 0.628 -0.069 1 0.138
STLK3STLK3 0.627 -0.089 1 0.184
EPHB4EPHB4 0.626 0.028 -1 0.803
PTK2PTK2 0.626 0.155 -1 0.747
FGRFGR 0.626 0.056 1 0.245
MAP2K7_TYRMAP2K7_TYR 0.625 -0.094 2 0.319
LIMK2_TYRLIMK2_TYR 0.625 -0.019 -3 0.600
PKMYT1_TYRPKMYT1_TYR 0.625 -0.030 3 0.804
EPHA6EPHA6 0.624 -0.005 -1 0.826
SRMSSRMS 0.624 0.067 1 0.313
ITKITK 0.623 0.060 -1 0.804
ABL2ABL2 0.622 0.012 -1 0.798
PINK1_TYRPINK1_TYR 0.622 -0.090 1 0.205
FERFER 0.622 0.029 1 0.266
BMXBMX 0.622 0.073 -1 0.726
EPHA4EPHA4 0.621 0.003 2 0.269
EPHB1EPHB1 0.621 0.040 1 0.293
INSRRINSRR 0.620 0.034 3 0.698
RETRET 0.620 -0.103 1 0.155
MERTKMERTK 0.620 0.037 3 0.710
YES1YES1 0.620 -0.008 -1 0.844
CSF1RCSF1R 0.619 -0.047 3 0.731
LCKLCK 0.619 0.030 -1 0.837
TYRO3TYRO3 0.619 -0.061 3 0.741
SYKSYK 0.619 0.125 -1 0.738
TNK2TNK2 0.619 -0.013 3 0.709
PTK2BPTK2B 0.618 0.099 -1 0.781
FYNFYN 0.618 0.050 -1 0.820
ROS1ROS1 0.618 -0.059 3 0.721
ABL1ABL1 0.618 -0.007 -1 0.792
BLKBLK 0.618 0.021 -1 0.834
AAK1AAK1 0.617 -0.054 1 0.099
EPHB2EPHB2 0.616 0.006 -1 0.778
EPHB3EPHB3 0.616 -0.017 -1 0.799
KITKIT 0.615 -0.021 3 0.737
EPHA7EPHA7 0.614 0.002 2 0.265
NEK10_TYRNEK10_TYR 0.614 -0.055 1 0.119
METMET 0.614 0.018 3 0.729
JAK3JAK3 0.614 -0.065 1 0.171
HCKHCK 0.614 -0.020 -1 0.833
AXLAXL 0.614 -0.037 3 0.717
MST1RMST1R 0.613 -0.119 3 0.754
JAK1JAK1 0.613 -0.037 1 0.138
JAK2JAK2 0.612 -0.133 1 0.138
TECTEC 0.612 0.018 -1 0.746
TYK2TYK2 0.612 -0.166 1 0.138
LIMK1_TYRLIMK1_TYR 0.611 -0.149 2 0.331
PDGFRBPDGFRB 0.610 -0.102 3 0.747
DDR1DDR1 0.610 -0.130 4 0.785
EPHA8EPHA8 0.610 0.012 -1 0.790
ERBB4ERBB4 0.610 0.044 1 0.266
FGFR2FGFR2 0.609 -0.111 3 0.749
FLT1FLT1 0.608 -0.027 -1 0.779
ERBB2ERBB2 0.607 -0.045 1 0.209
EGFREGFR 0.607 -0.032 1 0.197
ZAP70ZAP70 0.606 0.069 -1 0.672
TNK1TNK1 0.606 -0.113 3 0.728
SRCSRC 0.606 0.005 -1 0.812
ALKALK 0.606 -0.041 3 0.666
FRKFRK 0.606 -0.049 -1 0.830
KDRKDR 0.606 -0.082 3 0.700
EPHA5EPHA5 0.606 -0.019 2 0.246
NTRK3NTRK3 0.605 -0.015 -1 0.747
NTRK1NTRK1 0.605 -0.055 -1 0.786
INSRINSR 0.604 -0.043 3 0.681
PTK6PTK6 0.604 -0.068 -1 0.742
BTKBTK 0.604 -0.085 -1 0.783
EPHA3EPHA3 0.604 -0.050 2 0.251
FGFR3FGFR3 0.603 -0.083 3 0.719
MATKMATK 0.603 -0.016 -1 0.706
WEE1_TYRWEE1_TYR 0.603 -0.059 -1 0.737
FLT3FLT3 0.602 -0.134 3 0.735
EPHA1EPHA1 0.602 -0.081 3 0.709
LTKLTK 0.601 -0.088 3 0.688
CSKCSK 0.601 -0.046 2 0.265
DDR2DDR2 0.601 -0.068 3 0.693
TEKTEK 0.601 -0.134 3 0.689
TNNI3K_TYRTNNI3K_TYR 0.601 -0.122 1 0.115
FGFR1FGFR1 0.601 -0.148 3 0.705
EPHA2EPHA2 0.600 -0.005 -1 0.740
PDGFRAPDGFRA 0.600 -0.159 3 0.742
FGFR4FGFR4 0.600 -0.043 -1 0.723
LYNLYN 0.599 -0.040 3 0.670
NTRK2NTRK2 0.596 -0.102 3 0.686
IGF1RIGF1R 0.594 -0.021 3 0.627
FESFES 0.594 0.061 -1 0.699
FLT4FLT4 0.593 -0.134 3 0.699
MUSKMUSK 0.590 -0.092 1 0.179