Motif 380 (n=254)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AVK6 | E2F8 | S671 | ochoa | Transcription factor E2F8 (E2F-8) | Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}. |
| A6ND36 | FAM83G | S127 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| A6NF01 | POM121B | S298 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A8CG34 | POM121C | S691 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| B8ZZF3 | None | S185 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| O00311 | CDC7 | S239 | psp | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O14654 | IRS4 | S817 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14686 | KMT2D | S3467 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O43312 | MTSS1 | S261 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O43379 | WDR62 | S444 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43379 | WDR62 | S1049 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43482 | OIP5 | S47 | ochoa | Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. |
| O60343 | TBC1D4 | S644 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60381 | HBP1 | S89 | ochoa | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| O60381 | HBP1 | S134 | ochoa | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| O75175 | CNOT3 | S506 | ochoa | CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}. |
| O75179 | ANKRD17 | S2406 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75182 | SIN3B | S739 | ochoa | Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). {ECO:0000250|UniProtKB:Q62141, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| O75376 | NCOR1 | S917 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75478 | TADA2A | S361 | ochoa | Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}. |
| O75764 | TCEA3 | S163 | ochoa | Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| O75962 | TRIO | S2370 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94782 | USP1 | S66 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O95238 | SPDEF | S242 | psp | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}. |
| O95402 | MED26 | S177 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O95714 | HERC2 | S1365 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O95819 | MAP4K4 | S709 | psp | Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) | Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). Phosphorylates SMAD1 on Thr-322 (PubMed:21690388). {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9890973}. |
| P02686 | MBP | S205 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P09769 | FGR | S57 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0CG23 | ZNF853 | S62 | ochoa | Zinc finger protein 853 | None |
| P10072 | ZNF875 | S219 | ochoa | Zinc finger protein 875 (Krueppel-related zinc finger protein 1) (Protein HKR1) | May be involved in transcriptional regulation. |
| P14859 | POU2F1 | S85 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P15408 | FOSL2 | Y82 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P17600 | SYN1 | S513 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P18433 | PTPRA | S204 | ochoa | Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) | Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:P18052}. |
| P22607 | FGFR3 | S444 | ochoa | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}. |
| P25054 | APC | S2307 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25686 | DNAJB2 | S242 | ochoa | DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:15936278, ECO:0000269|PubMed:20889486, ECO:0000269|PubMed:21625540, ECO:0000269|PubMed:21719532, ECO:0000269|PubMed:22219199, ECO:0000269|PubMed:22396390, ECO:0000269|PubMed:24023695, ECO:0000269|PubMed:7957263}. |
| P28062 | PSMB8 | S28 | ochoa | Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein) | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. {ECO:0000269|PubMed:16423992, ECO:0000269|PubMed:19443843, ECO:0000269|PubMed:21881205, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:8163024}. |
| P35125 | USP6 | S1195 | ochoa | Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (RN-tre) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) | Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. May act as a GTPase-activating protein for RAB3A (PubMed:19077034). {ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172, ECO:0000269|PubMed:19077034, ECO:0000269|PubMed:20418905}. |
| P35869 | AHR | S693 | psp | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P38398 | BRCA1 | S1577 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42566 | EPS15 | S562 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P48048 | KCNJ1 | S183 | psp | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:7929082}. |
| P48378 | RFX2 | S170 | ochoa | DNA-binding protein RFX2 (Regulatory factor X 2) | Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene H1-6 (By similarity). {ECO:0000250|UniProtKB:P48379, ECO:0000269|PubMed:10330134}. |
| P48431 | SOX2 | S250 | ochoa|psp | Transcription factor SOX-2 | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). {ECO:0000250|UniProtKB:P48430, ECO:0000250|UniProtKB:P48432, ECO:0000269|PubMed:18035408}. |
| P48634 | PRRC2A | S1282 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S1670 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P51116 | FXR2 | S516 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P56524 | HDAC4 | S265 | ochoa|psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P78559 | MAP1A | S500 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P85299 | PRR5 | S288 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| P98082 | DAB2 | S393 | ochoa|psp | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q00059 | TFAM | S55 | psp | Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2) | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:19304746, PubMed:22841477). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:29445193, ECO:0000269|PubMed:32183942}. |
| Q03164 | KMT2A | S480 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S2813 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07890 | SOS2 | S1264 | ochoa | Son of sevenless homolog 2 (SOS-2) | Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000250|UniProtKB:Q62245}. |
| Q08AD1 | CAMSAP2 | S598 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q13009 | TIAM1 | S63 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13029 | PRDM2 | S742 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13094 | LCP2 | S376 | ochoa|psp | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q13105 | ZBTB17 | S156 | ochoa | Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60) | Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}. |
| Q13191 | CBLB | S634 | ochoa | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}. |
| Q13426 | XRCC4 | S259 | ochoa | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
| Q13950 | RUNX2 | S294 | ochoa|psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14242 | SELPLG | Y357 | ochoa | P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162) | A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269|PubMed:11566773, ECO:0000269|PubMed:12403782}.; FUNCTION: (Microbial infection) Acts as a receptor for enterovirus 71. {ECO:0000269|PubMed:19543284}. |
| Q14432 | PDE3A | S474 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14669 | TRIP12 | S312 | ochoa|psp | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14686 | NCOA6 | S1720 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14966 | ZNF638 | S1400 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15326 | ZMYND11 | S446 | ochoa | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}. |
| Q15772 | SPEG | S371 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15772 | SPEG | S1172 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16665 | HIF1A | S760 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q16832 | DDR2 | S460 | ochoa | Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) | Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:30449416, ECO:0000269|PubMed:9659899}. |
| Q2KHR3 | QSER1 | S487 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2KJY2 | KIF26B | S1083 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2M2Z5 | KIZ | S435 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q2NKX8 | ERCC6L | S945 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q3L8U1 | CHD9 | S203 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q3V6T2 | CCDC88A | S1652 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q53ET0 | CRTC2 | S489 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q562F6 | SGO2 | S1032 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5JSZ5 | PRRC2B | S1395 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SRE5 | NUP188 | S1708 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q5SYE7 | NHSL1 | S198 | ochoa | NHS-like protein 1 | None |
| Q5SYE7 | NHSL1 | S722 | ochoa | NHS-like protein 1 | None |
| Q5T9C2 | EEIG1 | S216 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5THJ4 | VPS13D | S1709 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VST9 | OBSCN | S7115 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT06 | CEP350 | S2829 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT52 | RPRD2 | S25 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | S476 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUA4 | ZNF318 | S39 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q68CP9 | ARID2 | S1725 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q68EM7 | ARHGAP17 | S845 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q69YN4 | VIRMA | S1578 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6FI81 | CIAPIN1 | S182 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q6KC79 | NIPBL | S135 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NV74 | CRACDL | S68 | ochoa | CRACD-like protein | None |
| Q6NZY4 | ZCCHC8 | S373 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6P5Q4 | LMOD2 | S399 | ochoa | Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin) | Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:25250574, PubMed:26370058, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713). {ECO:0000250|UniProtKB:Q3UHZ5, ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:25250574, ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:26417072}. |
| Q6UXY8 | TMC5 | S115 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
| Q6ZRI6 | C15orf39 | S107 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZRI6 | C15orf39 | S496 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZU35 | CRACD | S697 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZVF9 | GPRIN3 | S615 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q70CQ4 | USP31 | S1059 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q70CQ4 | USP31 | S1322 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q717R9 | CYS1 | S20 | ochoa | Cystin-1 (Cilia-associated protein) | None |
| Q76N32 | CEP68 | S603 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7L591 | DOK3 | S389 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7RTP6 | MICAL3 | S1225 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2Y5 | NRK | S1148 | ochoa | Nik-related protein kinase (EC 2.7.11.1) | May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). {ECO:0000250}. |
| Q7Z591 | AKNA | S996 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z698 | SPRED2 | S167 | ochoa|psp | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) | Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}. |
| Q7Z6B0 | CCDC91 | S69 | ochoa | Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) | Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}. |
| Q86UU0 | BCL9L | S1073 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86XN8 | MEX3D | S592 | ochoa | RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. |
| Q86XZ4 | SPATS2 | S210 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q86Z02 | HIPK1 | S1063 | ochoa | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q8IVL0 | NAV3 | S1220 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
| Q8IVL1 | NAV2 | S1301 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IVT2 | MISP | S213 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWC1 | MAP7D3 | S233 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IWC1 | MAP7D3 | S828 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IXI1 | RHOT2 | S535 | ochoa | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8IZ07 | ANKRD13A | S506 | ochoa | Ankyrin repeat domain-containing protein 13A (Protein KE03) | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}. |
| Q8IZD0 | SAMD14 | S287 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8N0Y2 | ZNF444 | S161 | ochoa | Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. |
| Q8N1F7 | NUP93 | S162 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N5Y2 | MSL3 | S311 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
| Q8ND82 | ZNF280C | S226 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
| Q8NDV7 | TNRC6A | S942 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NEM0 | MCPH1 | S276 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NEM0 | MCPH1 | S437 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NET4 | RTL9 | S1039 | ochoa | Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) | None |
| Q8NF50 | DOCK8 | S904 | ochoa | Dedicator of cytokinesis protein 8 | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}. |
| Q8NFA0 | USP32 | S1397 | ochoa | Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) | Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}. |
| Q8NFH8 | REPS2 | S198 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8TBP0 | TBC1D16 | S260 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TCN5 | ZNF507 | S721 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TDF6 | RASGRP4 | S183 | ochoa | RAS guanyl-releasing protein 4 | Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity). {ECO:0000250|UniProtKB:Q8BTM9, ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}. |
| Q8TDW5 | SYTL5 | S262 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TEW0 | PARD3 | Y1244 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF72 | SHROOM3 | S402 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8TF74 | WIPF2 | S155 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WUA4 | GTF3C2 | S892 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WVZ9 | KBTBD7 | S26 | ochoa | Kelch repeat and BTB domain-containing protein 7 | As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). {ECO:0000269|PubMed:25684205}. |
| Q8WWI1 | LMO7 | S895 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWI1 | LMO7 | S1565 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWN9 | IPCEF1 | S209 | ochoa | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}. |
| Q8WWQ0 | PHIP | S1559 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WXI9 | GATAD2B | S333 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q8WY36 | BBX | S886 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q8WZ75 | ROBO4 | S542 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92610 | ZNF592 | S529 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92613 | JADE3 | S619 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92793 | CREBBP | S92 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92900 | UPF1 | S1084 | psp | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q96CB8 | INTS12 | S426 | ochoa | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}. |
| Q96DN5 | TBC1D31 | S1014 | ochoa | TBC1 domain family member 31 (WD repeat-containing protein 67) | Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation. {ECO:0000269|PubMed:33934390}. |
| Q96GS4 | BORCS6 | S198 | ochoa | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}. |
| Q96GY3 | LIN37 | S137 | ochoa | Protein lin-37 homolog (Antolefinin) | None |
| Q96HA1 | POM121 | S714 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96HI0 | SENP5 | S362 | ochoa | Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. |
| Q96MK2 | RIPOR3 | S348 | ochoa | RIPOR family member 3 | None |
| Q96N21 | TEPSIN | S412 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
| Q96NM4 | TOX2 | S198 | ochoa | TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1) | Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system. |
| Q96T58 | SPEN | S2411 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T58 | SPEN | S2789 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99081 | TCF12 | S276 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99081 | TCF12 | S385 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99575 | POP1 | S65 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q99685 | MGLL | S196 | ochoa | Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL) | Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000269|PubMed:19029917, ECO:0000269|PubMed:20079333, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842}. |
| Q99759 | MAP3K3 | S250 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q99814 | EPAS1 | S435 | psp | Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}. |
| Q99958 | FOXC2 | S483 | ochoa | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BRD0 | BUD13 | S126 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRQ0 | PYGO2 | S318 | ochoa | Pygopus homolog 2 | Involved in signal transduction through the Wnt pathway. |
| Q9BRQ6 | CHCHD6 | S42 | ochoa | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}. |
| Q9BRS8 | LARP6 | S383 | ochoa | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
| Q9BT73 | PSMG3 | S58 | ochoa | Proteasome assembly chaperone 3 (PAC-3) (hPAC3) (Proteasome chaperone homolog 3) (Pba3) | Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. {ECO:0000269|PubMed:17189198}. |
| Q9BTE3 | MCMBP | S222 | ochoa | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}. |
| Q9BVR0 | HERC2P3 | S92 | ochoa | Putative HERC2-like protein 3 | None |
| Q9BXL6 | CARD14 | S474 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9BXL7 | CARD11 | S558 | psp | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9C0C6 | CIPC | S210 | ochoa | CLOCK-interacting pacemaker (CLOCK-interacting circadian protein) | Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock. {ECO:0000250|UniProtKB:Q8R0W1}. |
| Q9C0D2 | CEP295 | S913 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9C0D5 | TANC1 | S66 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0D7 | ZC3H12C | S491 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9C0D7 | ZC3H12C | S650 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9GZU3 | TMEM39B | S52 | ochoa | Transmembrane protein 39B | May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. {ECO:0000250|UniProtKB:Q7ZW11}. |
| Q9H201 | EPN3 | S358 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H6A9 | PCNX3 | S311 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6K5 | PRR36 | S250 | ochoa | Proline-rich protein 36 | None |
| Q9H706 | GAREM1 | S590 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
| Q9H7N4 | SCAF1 | S724 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H7U1 | CCSER2 | S133 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H992 | MARCHF7 | S388 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9HAP2 | MLXIP | S639 | ochoa | MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) | Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Q9HBD1 | RC3H2 | S549 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9HC35 | EML4 | S869 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9NQC3 | RTN4 | S449 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NRA8 | EIF4ENIF1 | S950 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRL2 | BAZ1A | S1320 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NS56 | TOPORS | S569 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NUJ3 | TCP11L1 | S55 | ochoa | T-complex protein 11-like protein 1 | None |
| Q9NUL3 | STAU2 | S485 | ochoa | Double-stranded RNA-binding protein Staufen homolog 2 | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}. |
| Q9NXE8 | CWC25 | S217 | ochoa | Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25) | Involved in pre-mRNA splicing as component of the spliceosome. {ECO:0000269|PubMed:29301961}. |
| Q9NZV7 | ZIM2 | S25 | ochoa | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| Q9P0J7 | KCMF1 | Y188 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P219 | CCDC88C | S1532 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P246 | STIM2 | S522 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P266 | JCAD | S982 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P270 | SLAIN2 | S413 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2P5 | HECW2 | S1170 | ochoa | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269|PubMed:12890487, ECO:0000269|PubMed:24163370}. |
| Q9UGJ0 | PRKAG2 | S164 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
| Q9UHB7 | AFF4 | S619 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHD8 | SEPTIN9 | S23 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UHD9 | UBQLN2 | S127 | ochoa | Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2) | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:24215460). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683). {ECO:0000269|PubMed:10983987, ECO:0000269|PubMed:18199683, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:24215460}. |
| Q9UIG0 | BAZ1B | S329 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UJF2 | RASAL2 | S829 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKF7 | PITPNC1 | S277 | ochoa | Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) | [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}. |
| Q9UKV0 | HDAC9 | S239 | ochoa|psp | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9ULL1 | PLEKHG1 | S695 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULS5 | TMCC3 | S36 | ochoa | Transmembrane and coiled-coil domain protein 3 | None |
| Q9ULT8 | HECTD1 | S1487 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UMS6 | SYNPO2 | S675 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UNY4 | TTF2 | S251 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPN3 | MACF1 | S7250 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPT8 | ZC3H4 | S899 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UPT8 | ZC3H4 | S1069 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQ35 | SRRM2 | S782 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S819 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1600 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1693 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ49 | NEU3 | S309 | ochoa | Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidasedis) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3) | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:10405317, PubMed:10861246, PubMed:11298736, PubMed:12011038, PubMed:15847605, PubMed:20511247, PubMed:28646141). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452). {ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:11298736, ECO:0000269|PubMed:12011038, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:17334392, ECO:0000269|PubMed:20511247, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:26251452, ECO:0000269|PubMed:28646141}. |
| Q9UQC2 | GAB2 | S622 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9UQL6 | HDAC5 | S278 | ochoa|psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9Y2U5 | MAP3K2 | S239 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y580 | RBM7 | S107 | ochoa | RNA-binding protein 7 (RNA-binding motif protein 7) | RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104, PubMed:27871484). NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:25189701, PubMed:25852104, PubMed:27871484). Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104). Participates in several biological processes including DNA damage response (DDR) and stress response (PubMed:25525152, PubMed:30824372). During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome (PubMed:25525152). Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability (PubMed:30824372). {ECO:0000269|PubMed:25189701, ECO:0000269|PubMed:25525152, ECO:0000269|PubMed:25578728, ECO:0000269|PubMed:25852104, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:30824372}. |
| Q9Y5W9 | SNX11 | S191 | ochoa | Sorting nexin-11 | Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes (PubMed:23615901). Regulates the levels of TRPV3 by promoting its trafficking from the cell membrane to lysosome for degradation (PubMed:26818531). {ECO:0000269|PubMed:23615901, ECO:0000269|PubMed:26818531}. |
| Q9Y6C2 | EMILIN1 | S281 | ochoa | EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) | Involved in elastic and collagen fibers formation. It is required for EFEMP2 deposition into the extracellular matrix, and collagen network assembly and cross-linking via protein-lysine 6-oxidase/LOX activity (PubMed:36351433). May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved in the processes that regulate vessel assembly. Has cell adhesive capacity. {ECO:0000269|PubMed:36351433}. |
| P07949 | RET | S1065 | Sugiyama | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| Q6UVK1 | CSPG4 | T1613 | Sugiyama | Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan) | Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. {ECO:0000269|PubMed:10587647, ECO:0000269|PubMed:11278606, ECO:0000269|PubMed:15210734}. |
| P17948 | FLT1 | S1288 | Sugiyama | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| P54750 | PDE1A | Y486 | Sugiyama | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) | Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. {ECO:0000269|PubMed:8557689}. |
| Q9Y2I6 | NINL | S87 | GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Q9Y624 | F11R | S34 | iPTMNet | Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321) | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. {ECO:0000269|PubMed:11239401}.; FUNCTION: (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}. |
| P29353 | SHC1 | S28 | SIGNOR | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| Q5S007 | LRRK2 | S1283 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q96L34 | MARK4 | S48 | Sugiyama | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) | Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}. |
| P40261 | NNMT | S213 | Sugiyama | Nicotinamide N-methyltransferase (EC 2.1.1.1) | Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23455543, PubMed:8182091). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:23455543, PubMed:26571212, PubMed:31043742). In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909). {ECO:0000250|UniProtKB:O55239, ECO:0000269|PubMed:21823666, ECO:0000269|PubMed:23455543, ECO:0000269|PubMed:26571212, ECO:0000269|PubMed:30044909, ECO:0000269|PubMed:31043742, ECO:0000269|PubMed:8182091}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.000216 | 3.665 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000103 | 3.987 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.000363 | 3.440 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.000192 | 3.717 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.000208 | 3.681 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.000318 | 3.498 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.000897 | 3.047 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000975 | 3.011 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.000801 | 3.097 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.000801 | 3.096 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.000672 | 3.172 |
| R-HSA-74160 | Gene expression (Transcription) | 0.001607 | 2.794 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.001937 | 2.713 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.002323 | 2.634 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 0.002753 | 2.560 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 0.002753 | 2.560 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.002912 | 2.536 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.003209 | 2.494 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.003209 | 2.494 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.002634 | 2.579 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.002912 | 2.536 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.002323 | 2.634 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.002602 | 2.585 |
| R-HSA-9842663 | Signaling by LTK | 0.002323 | 2.634 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.003230 | 2.491 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.004353 | 2.361 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.003864 | 2.413 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.003864 | 2.413 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.004223 | 2.374 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.005007 | 2.300 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.005186 | 2.285 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.005186 | 2.285 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.005186 | 2.285 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.005186 | 2.285 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.004111 | 2.386 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.004223 | 2.374 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.005007 | 2.300 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.005186 | 2.285 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.004604 | 2.337 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.004032 | 2.394 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.003835 | 2.416 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.006857 | 2.164 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.007381 | 2.132 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.006358 | 2.197 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.007251 | 2.140 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.005884 | 2.230 |
| R-HSA-9707616 | Heme signaling | 0.005844 | 2.233 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.005844 | 2.233 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.007381 | 2.132 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.007381 | 2.132 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.006358 | 2.197 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.006573 | 2.182 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.006857 | 2.164 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.006857 | 2.164 |
| R-HSA-201556 | Signaling by ALK | 0.006857 | 2.164 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.007087 | 2.150 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.007931 | 2.101 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.008218 | 2.085 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.009328 | 2.030 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.009489 | 2.023 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.010026 | 1.999 |
| R-HSA-9843745 | Adipogenesis | 0.010381 | 1.984 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.009748 | 2.011 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.010533 | 1.977 |
| R-HSA-9909396 | Circadian clock | 0.010742 | 1.969 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.011083 | 1.955 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.011083 | 1.955 |
| R-HSA-8849473 | PTK6 Expression | 0.011592 | 1.936 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.011797 | 1.928 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.012316 | 1.910 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.013334 | 1.875 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.013880 | 1.858 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.014311 | 1.844 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.015409 | 1.812 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.015409 | 1.812 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.015956 | 1.797 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.016703 | 1.777 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.016704 | 1.777 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.016704 | 1.777 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.019222 | 1.716 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.020944 | 1.679 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.021639 | 1.665 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.021789 | 1.662 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.021789 | 1.662 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.024753 | 1.606 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.024753 | 1.606 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.024297 | 1.614 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.021789 | 1.662 |
| R-HSA-191859 | snRNP Assembly | 0.023837 | 1.623 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.023837 | 1.623 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.022722 | 1.644 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.023015 | 1.638 |
| R-HSA-9930044 | Nuclear RNA decay | 0.025720 | 1.590 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.026167 | 1.582 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.026167 | 1.582 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.026847 | 1.571 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.026847 | 1.571 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.026847 | 1.571 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.031658 | 1.500 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.031658 | 1.500 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.029909 | 1.524 |
| R-HSA-4839726 | Chromatin organization | 0.031519 | 1.501 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.028798 | 1.541 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.029202 | 1.535 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.029202 | 1.535 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.032570 | 1.487 |
| R-HSA-190236 | Signaling by FGFR | 0.032597 | 1.487 |
| R-HSA-8853659 | RET signaling | 0.032919 | 1.483 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.032919 | 1.483 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.034548 | 1.462 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.035366 | 1.451 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.038096 | 1.419 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 0.038096 | 1.419 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.038096 | 1.419 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.038096 | 1.419 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.045583 | 1.341 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.042947 | 1.367 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.045583 | 1.341 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.044564 | 1.351 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.041055 | 1.387 |
| R-HSA-211000 | Gene Silencing by RNA | 0.044589 | 1.351 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.046216 | 1.335 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.046560 | 1.332 |
| R-HSA-163282 | Mitochondrial transcription initiation | 0.047111 | 1.327 |
| R-HSA-2033515 | t(4;14) translocations of FGFR3 | 0.047111 | 1.327 |
| R-HSA-8853334 | Signaling by FGFR3 fusions in cancer | 0.047111 | 1.327 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.053561 | 1.271 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.057722 | 1.239 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.057722 | 1.239 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.058716 | 1.231 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.059421 | 1.226 |
| R-HSA-73887 | Death Receptor Signaling | 0.061204 | 1.213 |
| R-HSA-1296067 | Potassium transport channels | 0.062317 | 1.205 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.077283 | 1.112 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.077283 | 1.112 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.070835 | 1.150 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.070835 | 1.150 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.068047 | 1.167 |
| R-HSA-1989781 | PPARA activates gene expression | 0.062567 | 1.204 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 0.062317 | 1.205 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.062657 | 1.203 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.062317 | 1.205 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.077283 | 1.112 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.070835 | 1.150 |
| R-HSA-9634597 | GPER1 signaling | 0.062657 | 1.203 |
| R-HSA-109704 | PI3K Cascade | 0.068047 | 1.167 |
| R-HSA-68875 | Mitotic Prophase | 0.066942 | 1.174 |
| R-HSA-3371556 | Cellular response to heat stress | 0.068619 | 1.164 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.068640 | 1.163 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.080061 | 1.097 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.080061 | 1.097 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.081613 | 1.088 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.092010 | 1.036 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.106503 | 0.973 |
| R-HSA-111957 | Cam-PDE 1 activation | 0.120766 | 0.918 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.120766 | 0.918 |
| R-HSA-9645135 | STAT5 Activation | 0.134801 | 0.870 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 0.134801 | 0.870 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 0.134801 | 0.870 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.134801 | 0.870 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 0.148614 | 0.828 |
| R-HSA-190371 | FGFR3b ligand binding and activation | 0.148614 | 0.828 |
| R-HSA-196025 | Formation of annular gap junctions | 0.162207 | 0.790 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.162207 | 0.790 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.175584 | 0.756 |
| R-HSA-190873 | Gap junction degradation | 0.175584 | 0.756 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.175584 | 0.756 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.201702 | 0.695 |
| R-HSA-4839744 | Signaling by APC mutants | 0.201702 | 0.695 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.201702 | 0.695 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.201702 | 0.695 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.201702 | 0.695 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.084806 | 1.072 |
| R-HSA-2022923 | DS-GAG biosynthesis | 0.214451 | 0.669 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.214451 | 0.669 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.226996 | 0.644 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.226996 | 0.644 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.226996 | 0.644 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.226996 | 0.644 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.226996 | 0.644 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.099524 | 1.002 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.263448 | 0.579 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.263448 | 0.579 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.263448 | 0.579 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.286793 | 0.542 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.286793 | 0.542 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.286793 | 0.542 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.286793 | 0.542 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.298188 | 0.526 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.101175 | 0.995 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.320435 | 0.494 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.331294 | 0.480 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.331294 | 0.480 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.331294 | 0.480 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.331294 | 0.480 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.331294 | 0.480 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.331294 | 0.480 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.197853 | 0.704 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.168133 | 0.774 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.114890 | 0.940 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.239342 | 0.621 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.114551 | 0.941 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.104579 | 0.981 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.148614 | 0.828 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.245436 | 0.610 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.120766 | 0.918 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.308698 | 0.510 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.175584 | 0.756 |
| R-HSA-9839394 | TGFBR3 expression | 0.089634 | 1.048 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.263448 | 0.579 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.152751 | 0.816 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.226996 | 0.644 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.152751 | 0.816 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.106503 | 0.973 |
| R-HSA-164843 | 2-LTR circle formation | 0.188747 | 0.724 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.251492 | 0.599 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.251492 | 0.599 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.309401 | 0.509 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.261268 | 0.583 |
| R-HSA-2424491 | DAP12 signaling | 0.114890 | 0.940 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.112227 | 0.950 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.118810 | 0.925 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.118810 | 0.925 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.269139 | 0.570 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.094739 | 1.023 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.287383 | 0.542 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 0.106503 | 0.973 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.148614 | 0.828 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.148614 | 0.828 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.162207 | 0.790 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.188747 | 0.724 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.201702 | 0.695 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.214451 | 0.669 |
| R-HSA-428540 | Activation of RAC1 | 0.214451 | 0.669 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.214451 | 0.669 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.214451 | 0.669 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.226996 | 0.644 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 0.251492 | 0.599 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.286793 | 0.542 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.309401 | 0.509 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.235316 | 0.628 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.296741 | 0.528 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.121477 | 0.916 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.226996 | 0.644 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.215726 | 0.666 |
| R-HSA-74749 | Signal attenuation | 0.188747 | 0.724 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.263448 | 0.579 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.188747 | 0.724 |
| R-HSA-8851805 | MET activates RAS signaling | 0.226996 | 0.644 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.309401 | 0.509 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.175584 | 0.756 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.309401 | 0.509 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.246218 | 0.609 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.090137 | 1.045 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.120766 | 0.918 |
| R-HSA-426048 | Arachidonate production from DAG | 0.188747 | 0.724 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.214451 | 0.669 |
| R-HSA-420029 | Tight junction interactions | 0.089634 | 1.048 |
| R-HSA-8963901 | Chylomicron remodeling | 0.239342 | 0.621 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.309401 | 0.509 |
| R-HSA-2172127 | DAP12 interactions | 0.204239 | 0.690 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.116131 | 0.935 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.184590 | 0.734 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.144004 | 0.842 |
| R-HSA-9907900 | Proteasome assembly | 0.204239 | 0.690 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.134801 | 0.870 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.130810 | 0.883 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.286793 | 0.542 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.230152 | 0.638 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.286793 | 0.542 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.309401 | 0.509 |
| R-HSA-9834899 | Specification of the neural plate border | 0.320435 | 0.494 |
| R-HSA-3214847 | HATs acetylate histones | 0.103151 | 0.987 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.083886 | 1.076 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.215945 | 0.666 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.120766 | 0.918 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.175584 | 0.756 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.214451 | 0.669 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.226996 | 0.644 |
| R-HSA-418457 | cGMP effects | 0.251492 | 0.599 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.275214 | 0.560 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.169641 | 0.770 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.286913 | 0.542 |
| R-HSA-9609690 | HCMV Early Events | 0.265970 | 0.575 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.275214 | 0.560 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.273892 | 0.562 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.298188 | 0.526 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.298188 | 0.526 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.159535 | 0.797 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.104579 | 0.981 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.141688 | 0.849 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.192608 | 0.715 |
| R-HSA-212436 | Generic Transcription Pathway | 0.099985 | 1.000 |
| R-HSA-68886 | M Phase | 0.118335 | 0.927 |
| R-HSA-157118 | Signaling by NOTCH | 0.128782 | 0.890 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.106503 | 0.973 |
| R-HSA-9613354 | Lipophagy | 0.175584 | 0.756 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.226996 | 0.644 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.226996 | 0.644 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.226996 | 0.644 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.309401 | 0.509 |
| R-HSA-177929 | Signaling by EGFR | 0.275067 | 0.561 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.298739 | 0.525 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.204239 | 0.690 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.298188 | 0.526 |
| R-HSA-418555 | G alpha (s) signalling events | 0.193261 | 0.714 |
| R-HSA-2262752 | Cellular responses to stress | 0.167803 | 0.775 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.162065 | 0.790 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.127003 | 0.896 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.114890 | 0.940 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.147198 | 0.832 |
| R-HSA-9758941 | Gastrulation | 0.282465 | 0.549 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.127003 | 0.896 |
| R-HSA-5578768 | Physiological factors | 0.251492 | 0.599 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.147198 | 0.832 |
| R-HSA-195721 | Signaling by WNT | 0.143561 | 0.843 |
| R-HSA-1640170 | Cell Cycle | 0.199112 | 0.701 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.238683 | 0.622 |
| R-HSA-68882 | Mitotic Anaphase | 0.331045 | 0.480 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.248922 | 0.604 |
| R-HSA-162592 | Integration of provirus | 0.214451 | 0.669 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.303913 | 0.517 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.181069 | 0.742 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.325991 | 0.487 |
| R-HSA-8848021 | Signaling by PTK6 | 0.107781 | 0.967 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.107781 | 0.967 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.097935 | 1.009 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.141168 | 0.850 |
| R-HSA-162582 | Signal Transduction | 0.091740 | 1.037 |
| R-HSA-1482883 | Acyl chain remodeling of DAG and TAG | 0.239342 | 0.621 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.263448 | 0.579 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.275214 | 0.560 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.141688 | 0.849 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.169842 | 0.770 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.273892 | 0.562 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.280992 | 0.551 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.197853 | 0.704 |
| R-HSA-112399 | IRS-mediated signalling | 0.088478 | 1.053 |
| R-HSA-166520 | Signaling by NTRKs | 0.131637 | 0.881 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.201702 | 0.695 |
| R-HSA-9830364 | Formation of the nephric duct | 0.089634 | 1.048 |
| R-HSA-9610379 | HCMV Late Events | 0.311105 | 0.507 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.085416 | 1.068 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.218496 | 0.661 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.161243 | 0.793 |
| R-HSA-9830369 | Kidney development | 0.121477 | 0.916 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.198413 | 0.702 |
| R-HSA-8939211 | ESR-mediated signaling | 0.234948 | 0.629 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.109702 | 0.960 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.165050 | 0.782 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.183845 | 0.736 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.252356 | 0.598 |
| R-HSA-70171 | Glycolysis | 0.105691 | 0.976 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.175431 | 0.756 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.331294 | 0.480 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.095875 | 1.018 |
| R-HSA-9664873 | Pexophagy | 0.188747 | 0.724 |
| R-HSA-210993 | Tie2 Signaling | 0.309401 | 0.509 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.107781 | 0.967 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.110856 | 0.955 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.117851 | 0.929 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.136388 | 0.865 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.165940 | 0.780 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.161243 | 0.793 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.269568 | 0.569 |
| R-HSA-70326 | Glucose metabolism | 0.161988 | 0.791 |
| R-HSA-72306 | tRNA processing | 0.190510 | 0.720 |
| R-HSA-162587 | HIV Life Cycle | 0.153601 | 0.814 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.257766 | 0.589 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.127326 | 0.895 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.243855 | 0.613 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.300324 | 0.522 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.334194 | 0.476 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.339282 | 0.469 |
| R-HSA-167044 | Signalling to RAS | 0.341981 | 0.466 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.341981 | 0.466 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.341981 | 0.466 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.341981 | 0.466 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.341981 | 0.466 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.341981 | 0.466 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.341981 | 0.466 |
| R-HSA-8951664 | Neddylation | 0.346813 | 0.460 |
| R-HSA-5619102 | SLC transporter disorders | 0.347252 | 0.459 |
| R-HSA-2022870 | CS-GAG biosynthesis | 0.352497 | 0.453 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.352497 | 0.453 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.352497 | 0.453 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.362845 | 0.440 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.362845 | 0.440 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.362845 | 0.440 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.362845 | 0.440 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.362975 | 0.440 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.362975 | 0.440 |
| R-HSA-162906 | HIV Infection | 0.365792 | 0.437 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.368958 | 0.433 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.373029 | 0.428 |
| R-HSA-200425 | Carnitine shuttle | 0.373029 | 0.428 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.373029 | 0.428 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.374439 | 0.427 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.378457 | 0.422 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.380140 | 0.420 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.380140 | 0.420 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.383051 | 0.417 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.383051 | 0.417 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.383051 | 0.417 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.383051 | 0.417 |
| R-HSA-429947 | Deadenylation of mRNA | 0.383051 | 0.417 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.383051 | 0.417 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.392913 | 0.406 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.392913 | 0.406 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.392913 | 0.406 |
| R-HSA-168255 | Influenza Infection | 0.394308 | 0.404 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.397108 | 0.401 |
| R-HSA-69481 | G2/M Checkpoints | 0.400026 | 0.398 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.402618 | 0.395 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.402618 | 0.395 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.402618 | 0.395 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.402618 | 0.395 |
| R-HSA-525793 | Myogenesis | 0.402618 | 0.395 |
| R-HSA-8949613 | Cristae formation | 0.412169 | 0.385 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.412169 | 0.385 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.412169 | 0.385 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.412169 | 0.385 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.412871 | 0.384 |
| R-HSA-6806834 | Signaling by MET | 0.413859 | 0.383 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.413859 | 0.383 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.419392 | 0.377 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.419707 | 0.377 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.421567 | 0.375 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.430816 | 0.366 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.430816 | 0.366 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.430816 | 0.366 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.430816 | 0.366 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.430816 | 0.366 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.435829 | 0.361 |
| R-HSA-9609646 | HCMV Infection | 0.438353 | 0.358 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.439917 | 0.357 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.439917 | 0.357 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.439917 | 0.357 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.439917 | 0.357 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.441252 | 0.355 |
| R-HSA-421270 | Cell-cell junction organization | 0.441477 | 0.355 |
| R-HSA-68877 | Mitotic Prometaphase | 0.444376 | 0.352 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.446646 | 0.350 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.446646 | 0.350 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.446673 | 0.350 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.447910 | 0.349 |
| R-HSA-182971 | EGFR downregulation | 0.448874 | 0.348 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.448874 | 0.348 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.448874 | 0.348 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.457687 | 0.339 |
| R-HSA-1538133 | G0 and Early G1 | 0.457687 | 0.339 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.457687 | 0.339 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.457687 | 0.339 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.457687 | 0.339 |
| R-HSA-6807070 | PTEN Regulation | 0.459153 | 0.338 |
| R-HSA-9663891 | Selective autophagy | 0.462654 | 0.335 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.463228 | 0.334 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.466361 | 0.331 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.466361 | 0.331 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.466361 | 0.331 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.466361 | 0.331 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.466361 | 0.331 |
| R-HSA-354192 | Integrin signaling | 0.466361 | 0.331 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.466361 | 0.331 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.466361 | 0.331 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.473174 | 0.325 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.474896 | 0.323 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.474896 | 0.323 |
| R-HSA-2024101 | CS/DS degradation | 0.474896 | 0.323 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.474896 | 0.323 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.474896 | 0.323 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.478387 | 0.320 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.483295 | 0.316 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.483295 | 0.316 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.483295 | 0.316 |
| R-HSA-72172 | mRNA Splicing | 0.486277 | 0.313 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.488719 | 0.311 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.491560 | 0.308 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.491560 | 0.308 |
| R-HSA-187687 | Signalling to ERKs | 0.491560 | 0.308 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.491560 | 0.308 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.499694 | 0.301 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.499694 | 0.301 |
| R-HSA-111933 | Calmodulin induced events | 0.499694 | 0.301 |
| R-HSA-111997 | CaM pathway | 0.499694 | 0.301 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.499694 | 0.301 |
| R-HSA-163560 | Triglyceride catabolism | 0.499694 | 0.301 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.499694 | 0.301 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.507698 | 0.294 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.507698 | 0.294 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.513983 | 0.289 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.515574 | 0.288 |
| R-HSA-1566948 | Elastic fibre formation | 0.515574 | 0.288 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.518936 | 0.285 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.523325 | 0.281 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.523325 | 0.281 |
| R-HSA-446728 | Cell junction organization | 0.523820 | 0.281 |
| R-HSA-202433 | Generation of second messenger molecules | 0.530953 | 0.275 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.530953 | 0.275 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.530953 | 0.275 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.530953 | 0.275 |
| R-HSA-3371568 | Attenuation phase | 0.530953 | 0.275 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.530953 | 0.275 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.533594 | 0.273 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.538458 | 0.269 |
| R-HSA-9607240 | FLT3 Signaling | 0.538458 | 0.269 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.538458 | 0.269 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.538458 | 0.269 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.545844 | 0.263 |
| R-HSA-1280218 | Adaptive Immune System | 0.551562 | 0.258 |
| R-HSA-165159 | MTOR signalling | 0.553113 | 0.257 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.553113 | 0.257 |
| R-HSA-111996 | Ca-dependent events | 0.553113 | 0.257 |
| R-HSA-9833110 | RSV-host interactions | 0.557340 | 0.254 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.560265 | 0.252 |
| R-HSA-8854214 | TBC/RABGAPs | 0.560265 | 0.252 |
| R-HSA-418346 | Platelet homeostasis | 0.566595 | 0.247 |
| R-HSA-190828 | Gap junction trafficking | 0.567304 | 0.246 |
| R-HSA-373752 | Netrin-1 signaling | 0.567304 | 0.246 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.567304 | 0.246 |
| R-HSA-156581 | Methylation | 0.567304 | 0.246 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.567304 | 0.246 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.574230 | 0.241 |
| R-HSA-774815 | Nucleosome assembly | 0.574230 | 0.241 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.574230 | 0.241 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.574230 | 0.241 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.574230 | 0.241 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.574230 | 0.241 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.575711 | 0.240 |
| R-HSA-1266738 | Developmental Biology | 0.577598 | 0.238 |
| R-HSA-9675135 | Diseases of DNA repair | 0.581046 | 0.236 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.581046 | 0.236 |
| R-HSA-75153 | Apoptotic execution phase | 0.581046 | 0.236 |
| R-HSA-202403 | TCR signaling | 0.584687 | 0.233 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.587753 | 0.231 |
| R-HSA-449147 | Signaling by Interleukins | 0.593261 | 0.227 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.593522 | 0.227 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.594353 | 0.226 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.594353 | 0.226 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.594353 | 0.226 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.597679 | 0.224 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.597679 | 0.224 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.597887 | 0.223 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.600848 | 0.221 |
| R-HSA-9766229 | Degradation of CDH1 | 0.600848 | 0.221 |
| R-HSA-73893 | DNA Damage Bypass | 0.600848 | 0.221 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.602217 | 0.220 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.613528 | 0.212 |
| R-HSA-912446 | Meiotic recombination | 0.613528 | 0.212 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.613528 | 0.212 |
| R-HSA-9864848 | Complex IV assembly | 0.613528 | 0.212 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.614996 | 0.211 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.614996 | 0.211 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.619717 | 0.208 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.619717 | 0.208 |
| R-HSA-2559583 | Cellular Senescence | 0.621802 | 0.206 |
| R-HSA-8953854 | Metabolism of RNA | 0.623257 | 0.205 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.623792 | 0.205 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.625807 | 0.204 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.625807 | 0.204 |
| R-HSA-1221632 | Meiotic synapsis | 0.625807 | 0.204 |
| R-HSA-5693538 | Homology Directed Repair | 0.627459 | 0.202 |
| R-HSA-1500931 | Cell-Cell communication | 0.629732 | 0.201 |
| R-HSA-913531 | Interferon Signaling | 0.633429 | 0.198 |
| R-HSA-9675108 | Nervous system development | 0.636120 | 0.196 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.637698 | 0.195 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.637698 | 0.195 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.639608 | 0.194 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.643501 | 0.191 |
| R-HSA-5688426 | Deubiquitination | 0.646684 | 0.189 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.647534 | 0.189 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.649212 | 0.188 |
| R-HSA-5617833 | Cilium Assembly | 0.654527 | 0.184 |
| R-HSA-69206 | G1/S Transition | 0.659163 | 0.181 |
| R-HSA-194138 | Signaling by VEGF | 0.659163 | 0.181 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.660361 | 0.180 |
| R-HSA-4085001 | Sialic acid metabolism | 0.660361 | 0.180 |
| R-HSA-8979227 | Triglyceride metabolism | 0.660361 | 0.180 |
| R-HSA-186712 | Regulation of beta-cell development | 0.660361 | 0.180 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.665803 | 0.177 |
| R-HSA-983189 | Kinesins | 0.665803 | 0.177 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.665803 | 0.177 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.670484 | 0.174 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.671158 | 0.173 |
| R-HSA-112043 | PLC beta mediated events | 0.671158 | 0.173 |
| R-HSA-211976 | Endogenous sterols | 0.671158 | 0.173 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.673169 | 0.172 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.676427 | 0.170 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.676427 | 0.170 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.681612 | 0.166 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.681612 | 0.166 |
| R-HSA-211981 | Xenobiotics | 0.686715 | 0.163 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.689613 | 0.161 |
| R-HSA-422475 | Axon guidance | 0.692399 | 0.160 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.696677 | 0.157 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.701539 | 0.154 |
| R-HSA-112040 | G-protein mediated events | 0.701539 | 0.154 |
| R-HSA-196807 | Nicotinate metabolism | 0.701539 | 0.154 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.706323 | 0.151 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.709214 | 0.149 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.709411 | 0.149 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.715664 | 0.145 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.715664 | 0.145 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.715664 | 0.145 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.715664 | 0.145 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.715664 | 0.145 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.715664 | 0.145 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.715664 | 0.145 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.719340 | 0.143 |
| R-HSA-9664407 | Parasite infection | 0.719340 | 0.143 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.719340 | 0.143 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.720222 | 0.143 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.720222 | 0.143 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.720222 | 0.143 |
| R-HSA-1632852 | Macroautophagy | 0.722586 | 0.141 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.724708 | 0.140 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.724708 | 0.140 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.729122 | 0.137 |
| R-HSA-4086398 | Ca2+ pathway | 0.729122 | 0.137 |
| R-HSA-73894 | DNA Repair | 0.732891 | 0.135 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.733466 | 0.135 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.733466 | 0.135 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.735256 | 0.134 |
| R-HSA-388396 | GPCR downstream signalling | 0.735921 | 0.133 |
| R-HSA-380287 | Centrosome maturation | 0.737741 | 0.132 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.737741 | 0.132 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.737741 | 0.132 |
| R-HSA-418990 | Adherens junctions interactions | 0.737760 | 0.132 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.741404 | 0.130 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.741947 | 0.130 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.750158 | 0.125 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.750158 | 0.125 |
| R-HSA-216083 | Integrin cell surface interactions | 0.750158 | 0.125 |
| R-HSA-9659379 | Sensory processing of sound | 0.754166 | 0.123 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.756245 | 0.121 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.758109 | 0.120 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.758109 | 0.120 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.761990 | 0.118 |
| R-HSA-9612973 | Autophagy | 0.770348 | 0.113 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.773264 | 0.112 |
| R-HSA-1500620 | Meiosis | 0.776902 | 0.110 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.776902 | 0.110 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.780482 | 0.108 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.783169 | 0.106 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.787472 | 0.104 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.790883 | 0.102 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.791438 | 0.102 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.794240 | 0.100 |
| R-HSA-202424 | Downstream TCR signaling | 0.797543 | 0.098 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.797543 | 0.098 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.803991 | 0.095 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.807138 | 0.093 |
| R-HSA-2029481 | FCGR activation | 0.810235 | 0.091 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.810806 | 0.091 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.813282 | 0.090 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.815392 | 0.089 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.816281 | 0.088 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.817647 | 0.087 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.819878 | 0.086 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.822134 | 0.085 |
| R-HSA-1296071 | Potassium Channels | 0.822134 | 0.085 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.822134 | 0.085 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.830568 | 0.081 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.835969 | 0.078 |
| R-HSA-416476 | G alpha (q) signalling events | 0.836376 | 0.078 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.838604 | 0.076 |
| R-HSA-372790 | Signaling by GPCR | 0.839596 | 0.076 |
| R-HSA-69275 | G2/M Transition | 0.842852 | 0.074 |
| R-HSA-111885 | Opioid Signalling | 0.843749 | 0.074 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.843749 | 0.074 |
| R-HSA-199991 | Membrane Trafficking | 0.846213 | 0.073 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.846260 | 0.072 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.846733 | 0.072 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.853032 | 0.069 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.855908 | 0.068 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.858224 | 0.066 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.864953 | 0.063 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.864953 | 0.063 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.869261 | 0.061 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.875467 | 0.058 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.879441 | 0.056 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.882591 | 0.054 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.887014 | 0.052 |
| R-HSA-73886 | Chromosome Maintenance | 0.887014 | 0.052 |
| R-HSA-168256 | Immune System | 0.890288 | 0.050 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.890620 | 0.050 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.897493 | 0.047 |
| R-HSA-9679506 | SARS-CoV Infections | 0.903584 | 0.044 |
| R-HSA-109582 | Hemostasis | 0.903656 | 0.044 |
| R-HSA-1474165 | Reproduction | 0.905482 | 0.043 |
| R-HSA-5576891 | Cardiac conduction | 0.907004 | 0.042 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.907004 | 0.042 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.908501 | 0.042 |
| R-HSA-597592 | Post-translational protein modification | 0.911464 | 0.040 |
| R-HSA-163685 | Integration of energy metabolism | 0.915636 | 0.038 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.915636 | 0.038 |
| R-HSA-8957322 | Metabolism of steroids | 0.915925 | 0.038 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.922216 | 0.035 |
| R-HSA-1474244 | Extracellular matrix organization | 0.922451 | 0.035 |
| R-HSA-2187338 | Visual phototransduction | 0.930577 | 0.031 |
| R-HSA-69242 | S Phase | 0.931697 | 0.031 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.933881 | 0.030 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.935996 | 0.029 |
| R-HSA-69306 | DNA Replication | 0.937028 | 0.028 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.940993 | 0.026 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.941945 | 0.026 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.942935 | 0.026 |
| R-HSA-109581 | Apoptosis | 0.945601 | 0.024 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.947343 | 0.023 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.949851 | 0.022 |
| R-HSA-6798695 | Neutrophil degranulation | 0.950183 | 0.022 |
| R-HSA-9658195 | Leishmania infection | 0.955242 | 0.020 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.955242 | 0.020 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.955251 | 0.020 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.955251 | 0.020 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.958577 | 0.018 |
| R-HSA-611105 | Respiratory electron transport | 0.958749 | 0.018 |
| R-HSA-3781865 | Diseases of glycosylation | 0.962589 | 0.017 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.967692 | 0.014 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.971176 | 0.013 |
| R-HSA-428157 | Sphingolipid metabolism | 0.971643 | 0.012 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.972553 | 0.012 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.972553 | 0.012 |
| R-HSA-5357801 | Programmed Cell Death | 0.973863 | 0.012 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.974872 | 0.011 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.976684 | 0.010 |
| R-HSA-397014 | Muscle contraction | 0.976684 | 0.010 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.982622 | 0.008 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.984999 | 0.007 |
| R-HSA-112316 | Neuronal System | 0.985766 | 0.006 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.985871 | 0.006 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.992077 | 0.003 |
| R-HSA-1483257 | Phospholipid metabolism | 0.994004 | 0.003 |
| R-HSA-9824446 | Viral Infection Pathways | 0.995775 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.996904 | 0.001 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.997184 | 0.001 |
| R-HSA-1643685 | Disease | 0.997447 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.998630 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.998765 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.999067 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 0.999067 | 0.000 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.999272 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999330 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999460 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999784 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999831 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999972 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.816 | 0.276 | 1 | 0.734 |
COT |
0.807 | 0.045 | 2 | 0.239 |
CLK3 |
0.804 | 0.139 | 1 | 0.620 |
PIM3 |
0.803 | 0.107 | -3 | 0.854 |
HIPK4 |
0.803 | 0.175 | 1 | 0.557 |
MOS |
0.801 | 0.155 | 1 | 0.694 |
NDR2 |
0.799 | 0.062 | -3 | 0.853 |
PRKD1 |
0.797 | 0.123 | -3 | 0.841 |
CHAK2 |
0.794 | 0.177 | -1 | 0.843 |
SKMLCK |
0.794 | 0.103 | -2 | 0.884 |
AURC |
0.794 | 0.134 | -2 | 0.721 |
RSK2 |
0.794 | 0.085 | -3 | 0.783 |
PRKD2 |
0.792 | 0.116 | -3 | 0.781 |
RAF1 |
0.791 | 0.039 | 1 | 0.652 |
KIS |
0.791 | 0.074 | 1 | 0.484 |
BMPR1B |
0.791 | 0.219 | 1 | 0.806 |
GRK1 |
0.790 | 0.075 | -2 | 0.799 |
PRPK |
0.790 | -0.042 | -1 | 0.841 |
NLK |
0.790 | -0.002 | 1 | 0.613 |
CAMK1B |
0.789 | 0.025 | -3 | 0.881 |
MTOR |
0.789 | -0.004 | 1 | 0.575 |
NDR1 |
0.789 | 0.025 | -3 | 0.846 |
TBK1 |
0.788 | -0.055 | 1 | 0.538 |
P90RSK |
0.788 | 0.056 | -3 | 0.787 |
ICK |
0.788 | 0.094 | -3 | 0.856 |
PIM1 |
0.788 | 0.074 | -3 | 0.801 |
ATR |
0.788 | 0.018 | 1 | 0.606 |
CDKL1 |
0.788 | 0.044 | -3 | 0.821 |
CDKL5 |
0.787 | 0.051 | -3 | 0.811 |
DAPK2 |
0.787 | 0.121 | -3 | 0.885 |
RSK4 |
0.786 | 0.098 | -3 | 0.750 |
MAPKAPK2 |
0.786 | 0.081 | -3 | 0.743 |
IKKB |
0.786 | -0.038 | -2 | 0.731 |
GCN2 |
0.786 | -0.139 | 2 | 0.247 |
ERK5 |
0.786 | -0.013 | 1 | 0.583 |
RSK3 |
0.784 | 0.044 | -3 | 0.779 |
HIPK2 |
0.784 | 0.085 | 1 | 0.437 |
PAK1 |
0.784 | 0.041 | -2 | 0.848 |
GRK5 |
0.784 | 0.021 | -3 | 0.896 |
CAMLCK |
0.784 | 0.060 | -2 | 0.874 |
MST4 |
0.784 | 0.012 | 2 | 0.299 |
CAMK2G |
0.784 | -0.081 | 2 | 0.252 |
AMPKA1 |
0.784 | 0.070 | -3 | 0.869 |
ULK2 |
0.784 | -0.143 | 2 | 0.248 |
CDK7 |
0.783 | 0.055 | 1 | 0.495 |
LATS2 |
0.783 | 0.019 | -5 | 0.767 |
PKCD |
0.783 | 0.001 | 2 | 0.245 |
PKACG |
0.783 | 0.052 | -2 | 0.778 |
IKKE |
0.783 | -0.070 | 1 | 0.539 |
P70S6KB |
0.782 | 0.049 | -3 | 0.810 |
MAPKAPK3 |
0.782 | 0.051 | -3 | 0.789 |
PKN3 |
0.782 | -0.040 | -3 | 0.845 |
SRPK1 |
0.781 | 0.046 | -3 | 0.765 |
TGFBR2 |
0.781 | 0.006 | -2 | 0.726 |
CDK18 |
0.781 | 0.043 | 1 | 0.446 |
NIK |
0.781 | -0.010 | -3 | 0.900 |
IKKA |
0.781 | 0.010 | -2 | 0.718 |
FAM20C |
0.781 | -0.047 | 2 | 0.170 |
PKN2 |
0.781 | -0.017 | -3 | 0.853 |
PDHK4 |
0.780 | -0.161 | 1 | 0.636 |
CDK8 |
0.780 | 0.012 | 1 | 0.477 |
GRK6 |
0.780 | 0.038 | 1 | 0.729 |
TGFBR1 |
0.780 | 0.106 | -2 | 0.734 |
BMPR2 |
0.780 | -0.067 | -2 | 0.840 |
MARK4 |
0.780 | -0.000 | 4 | 0.855 |
RIPK3 |
0.780 | -0.045 | 3 | 0.724 |
CDK19 |
0.780 | 0.028 | 1 | 0.448 |
PKACB |
0.780 | 0.100 | -2 | 0.723 |
PAK3 |
0.780 | 0.013 | -2 | 0.839 |
CAMK2B |
0.778 | 0.003 | 2 | 0.228 |
AURB |
0.778 | 0.086 | -2 | 0.718 |
AMPKA2 |
0.778 | 0.063 | -3 | 0.833 |
DYRK2 |
0.778 | 0.018 | 1 | 0.504 |
CAMK2A |
0.777 | 0.029 | 2 | 0.244 |
DSTYK |
0.777 | -0.101 | 2 | 0.252 |
PRKX |
0.777 | 0.122 | -3 | 0.681 |
ALK4 |
0.777 | 0.097 | -2 | 0.767 |
CAMK2D |
0.777 | -0.042 | -3 | 0.860 |
GRK7 |
0.777 | 0.100 | 1 | 0.658 |
NEK6 |
0.776 | -0.056 | -2 | 0.793 |
NUAK2 |
0.776 | -0.009 | -3 | 0.856 |
WNK1 |
0.776 | -0.073 | -2 | 0.886 |
MLK3 |
0.776 | -0.038 | 2 | 0.218 |
MLK1 |
0.776 | -0.114 | 2 | 0.228 |
PKCA |
0.776 | -0.008 | 2 | 0.223 |
PDHK1 |
0.775 | -0.153 | 1 | 0.603 |
HIPK1 |
0.775 | 0.064 | 1 | 0.509 |
ULK1 |
0.775 | -0.149 | -3 | 0.845 |
PKCG |
0.775 | -0.016 | 2 | 0.212 |
CLK2 |
0.775 | 0.090 | -3 | 0.763 |
MSK1 |
0.775 | 0.056 | -3 | 0.763 |
BRSK1 |
0.775 | 0.020 | -3 | 0.804 |
HUNK |
0.775 | -0.105 | 2 | 0.218 |
MLK2 |
0.775 | -0.049 | 2 | 0.272 |
MASTL |
0.774 | -0.114 | -2 | 0.807 |
PAK2 |
0.774 | 0.018 | -2 | 0.835 |
PKCB |
0.774 | -0.029 | 2 | 0.209 |
TSSK2 |
0.774 | -0.027 | -5 | 0.824 |
DLK |
0.773 | -0.025 | 1 | 0.663 |
TSSK1 |
0.773 | -0.003 | -3 | 0.888 |
CDK1 |
0.773 | 0.028 | 1 | 0.506 |
ACVR2B |
0.773 | 0.152 | -2 | 0.719 |
LATS1 |
0.773 | 0.053 | -3 | 0.860 |
NIM1 |
0.773 | -0.072 | 3 | 0.760 |
MSK2 |
0.773 | 0.011 | -3 | 0.760 |
GRK2 |
0.773 | 0.122 | -2 | 0.687 |
AURA |
0.773 | 0.070 | -2 | 0.698 |
BMPR1A |
0.773 | 0.157 | 1 | 0.778 |
DRAK1 |
0.773 | 0.109 | 1 | 0.783 |
PAK6 |
0.772 | 0.026 | -2 | 0.776 |
CDK17 |
0.772 | 0.014 | 1 | 0.425 |
JNK2 |
0.772 | 0.011 | 1 | 0.462 |
QSK |
0.772 | 0.048 | 4 | 0.836 |
SRPK2 |
0.772 | 0.034 | -3 | 0.689 |
MNK1 |
0.772 | 0.010 | -2 | 0.827 |
BCKDK |
0.772 | -0.117 | -1 | 0.794 |
CAMK4 |
0.772 | -0.028 | -3 | 0.838 |
MNK2 |
0.771 | -0.001 | -2 | 0.825 |
PKG2 |
0.771 | 0.049 | -2 | 0.720 |
TTBK2 |
0.771 | -0.138 | 2 | 0.203 |
MYLK4 |
0.771 | 0.056 | -2 | 0.813 |
PRKD3 |
0.771 | 0.033 | -3 | 0.754 |
ACVR2A |
0.771 | 0.117 | -2 | 0.707 |
CHAK1 |
0.770 | 0.011 | 2 | 0.339 |
PIM2 |
0.770 | 0.069 | -3 | 0.758 |
NEK7 |
0.770 | -0.146 | -3 | 0.860 |
PLK1 |
0.770 | -0.004 | -2 | 0.741 |
GRK4 |
0.769 | -0.068 | -2 | 0.789 |
CLK4 |
0.769 | 0.053 | -3 | 0.781 |
MLK4 |
0.769 | -0.063 | 2 | 0.199 |
P38B |
0.769 | 0.029 | 1 | 0.460 |
WNK3 |
0.768 | -0.186 | 1 | 0.584 |
IRE1 |
0.768 | -0.110 | 1 | 0.557 |
MARK3 |
0.768 | 0.039 | 4 | 0.800 |
RIPK1 |
0.768 | -0.115 | 1 | 0.595 |
DYRK1A |
0.768 | 0.039 | 1 | 0.520 |
IRE2 |
0.768 | -0.087 | 2 | 0.231 |
ERK1 |
0.768 | 0.009 | 1 | 0.444 |
MELK |
0.768 | -0.034 | -3 | 0.816 |
P38A |
0.767 | 0.018 | 1 | 0.505 |
PKCZ |
0.767 | -0.040 | 2 | 0.245 |
PHKG1 |
0.767 | -0.046 | -3 | 0.843 |
CDK5 |
0.767 | -0.011 | 1 | 0.511 |
DYRK4 |
0.767 | 0.004 | 1 | 0.456 |
NEK9 |
0.767 | -0.150 | 2 | 0.258 |
PKCH |
0.767 | -0.054 | 2 | 0.199 |
CDK14 |
0.766 | 0.018 | 1 | 0.483 |
SGK3 |
0.766 | 0.020 | -3 | 0.768 |
CLK1 |
0.766 | 0.046 | -3 | 0.753 |
P38G |
0.766 | -0.000 | 1 | 0.419 |
SIK |
0.766 | 0.018 | -3 | 0.778 |
CDK16 |
0.766 | 0.022 | 1 | 0.427 |
CDK13 |
0.766 | -0.023 | 1 | 0.469 |
HIPK3 |
0.766 | 0.031 | 1 | 0.489 |
MEK1 |
0.766 | -0.036 | 2 | 0.278 |
BRSK2 |
0.766 | -0.037 | -3 | 0.828 |
ANKRD3 |
0.765 | -0.128 | 1 | 0.634 |
ATM |
0.765 | -0.043 | 1 | 0.564 |
JNK3 |
0.765 | -0.019 | 1 | 0.478 |
PASK |
0.764 | 0.099 | -3 | 0.871 |
PKR |
0.763 | -0.079 | 1 | 0.611 |
ALK2 |
0.763 | 0.039 | -2 | 0.746 |
SRPK3 |
0.763 | 0.004 | -3 | 0.742 |
DYRK1B |
0.763 | 0.027 | 1 | 0.486 |
QIK |
0.763 | -0.051 | -3 | 0.851 |
AKT2 |
0.763 | 0.041 | -3 | 0.699 |
CDK10 |
0.762 | 0.021 | 1 | 0.474 |
PLK4 |
0.762 | -0.120 | 2 | 0.193 |
SNRK |
0.762 | -0.114 | 2 | 0.224 |
MARK2 |
0.762 | 0.002 | 4 | 0.756 |
PLK3 |
0.761 | -0.072 | 2 | 0.223 |
NEK2 |
0.761 | -0.088 | 2 | 0.278 |
CK2A2 |
0.761 | 0.096 | 1 | 0.746 |
NUAK1 |
0.761 | -0.032 | -3 | 0.800 |
CDK12 |
0.761 | -0.020 | 1 | 0.449 |
YSK4 |
0.761 | -0.094 | 1 | 0.588 |
MPSK1 |
0.761 | 0.065 | 1 | 0.541 |
DNAPK |
0.761 | -0.036 | 1 | 0.491 |
PKACA |
0.760 | 0.065 | -2 | 0.674 |
DCAMKL1 |
0.760 | -0.018 | -3 | 0.796 |
SMG1 |
0.760 | -0.028 | 1 | 0.550 |
CK1E |
0.760 | 0.032 | -3 | 0.625 |
P38D |
0.760 | 0.020 | 1 | 0.388 |
MARK1 |
0.759 | 0.001 | 4 | 0.814 |
TLK2 |
0.759 | -0.051 | 1 | 0.582 |
VRK2 |
0.759 | -0.169 | 1 | 0.621 |
ERK2 |
0.759 | -0.037 | 1 | 0.482 |
CHK1 |
0.759 | -0.012 | -3 | 0.840 |
CDK3 |
0.759 | 0.004 | 1 | 0.438 |
MST3 |
0.758 | 0.010 | 2 | 0.271 |
ERK7 |
0.758 | -0.046 | 2 | 0.155 |
MAK |
0.758 | 0.111 | -2 | 0.889 |
P70S6K |
0.758 | 0.021 | -3 | 0.718 |
CAMK1G |
0.758 | -0.033 | -3 | 0.779 |
GRK3 |
0.757 | 0.083 | -2 | 0.643 |
SSTK |
0.757 | -0.031 | 4 | 0.818 |
DYRK3 |
0.757 | 0.024 | 1 | 0.505 |
CDK9 |
0.757 | -0.044 | 1 | 0.470 |
PAK5 |
0.757 | 0.024 | -2 | 0.731 |
PAK4 |
0.756 | 0.021 | -2 | 0.740 |
DAPK3 |
0.756 | 0.085 | -3 | 0.814 |
PKCT |
0.755 | -0.053 | 2 | 0.212 |
DCAMKL2 |
0.755 | -0.048 | -3 | 0.819 |
SMMLCK |
0.754 | 0.025 | -3 | 0.833 |
CDK2 |
0.754 | -0.046 | 1 | 0.578 |
PRP4 |
0.754 | -0.008 | -3 | 0.783 |
DAPK1 |
0.753 | 0.090 | -3 | 0.798 |
CK2A1 |
0.753 | 0.092 | 1 | 0.753 |
BRAF |
0.752 | -0.070 | -4 | 0.847 |
TAO3 |
0.752 | 0.009 | 1 | 0.606 |
AKT1 |
0.752 | 0.028 | -3 | 0.715 |
MEK5 |
0.752 | -0.138 | 2 | 0.266 |
PKCI |
0.751 | -0.042 | 2 | 0.226 |
IRAK4 |
0.751 | -0.117 | 1 | 0.543 |
LKB1 |
0.751 | 0.092 | -3 | 0.855 |
CK1D |
0.751 | 0.043 | -3 | 0.575 |
MOK |
0.751 | 0.083 | 1 | 0.511 |
PKCE |
0.750 | -0.013 | 2 | 0.212 |
GCK |
0.750 | 0.084 | 1 | 0.660 |
ZAK |
0.750 | -0.130 | 1 | 0.581 |
MAPKAPK5 |
0.750 | -0.065 | -3 | 0.739 |
CAMK1D |
0.749 | 0.008 | -3 | 0.691 |
MEKK1 |
0.749 | -0.138 | 1 | 0.575 |
PERK |
0.749 | -0.140 | -2 | 0.768 |
BUB1 |
0.748 | 0.121 | -5 | 0.778 |
CK1A2 |
0.748 | 0.030 | -3 | 0.574 |
PHKG2 |
0.748 | -0.087 | -3 | 0.810 |
NEK5 |
0.747 | -0.106 | 1 | 0.588 |
GSK3A |
0.747 | 0.016 | 4 | 0.477 |
MEKK2 |
0.747 | -0.143 | 2 | 0.240 |
MEKK3 |
0.747 | -0.151 | 1 | 0.625 |
WNK4 |
0.747 | -0.136 | -2 | 0.874 |
PINK1 |
0.747 | -0.071 | 1 | 0.581 |
NEK11 |
0.746 | -0.060 | 1 | 0.611 |
TTBK1 |
0.746 | -0.145 | 2 | 0.178 |
JNK1 |
0.746 | -0.023 | 1 | 0.471 |
TLK1 |
0.746 | -0.104 | -2 | 0.757 |
GSK3B |
0.745 | 0.001 | 4 | 0.470 |
YANK3 |
0.745 | -0.031 | 2 | 0.126 |
AKT3 |
0.744 | 0.040 | -3 | 0.633 |
ROCK2 |
0.744 | 0.058 | -3 | 0.795 |
SGK1 |
0.744 | 0.045 | -3 | 0.615 |
HPK1 |
0.743 | 0.045 | 1 | 0.642 |
GAK |
0.743 | -0.035 | 1 | 0.637 |
MRCKA |
0.743 | 0.049 | -3 | 0.761 |
CK1G1 |
0.743 | -0.038 | -3 | 0.606 |
CDK6 |
0.742 | -0.027 | 1 | 0.448 |
MAP3K15 |
0.742 | -0.052 | 1 | 0.553 |
CDK4 |
0.742 | -0.024 | 1 | 0.439 |
CAMKK1 |
0.742 | -0.084 | -2 | 0.743 |
CAMKK2 |
0.741 | -0.023 | -2 | 0.747 |
HRI |
0.741 | -0.181 | -2 | 0.787 |
PLK2 |
0.741 | -0.027 | -3 | 0.835 |
MEKK6 |
0.741 | -0.087 | 1 | 0.574 |
TAO2 |
0.740 | -0.078 | 2 | 0.281 |
MRCKB |
0.740 | 0.031 | -3 | 0.746 |
LOK |
0.740 | -0.013 | -2 | 0.778 |
PBK |
0.739 | 0.029 | 1 | 0.547 |
STK33 |
0.739 | -0.105 | 2 | 0.191 |
TNIK |
0.739 | -0.005 | 3 | 0.829 |
PKN1 |
0.739 | -0.049 | -3 | 0.735 |
NEK8 |
0.739 | -0.139 | 2 | 0.255 |
KHS1 |
0.739 | 0.030 | 1 | 0.583 |
PDK1 |
0.739 | -0.074 | 1 | 0.571 |
MINK |
0.739 | -0.012 | 1 | 0.593 |
KHS2 |
0.738 | 0.045 | 1 | 0.618 |
MST2 |
0.738 | -0.060 | 1 | 0.631 |
HGK |
0.738 | -0.034 | 3 | 0.823 |
CHK2 |
0.737 | 0.009 | -3 | 0.642 |
NEK4 |
0.737 | -0.074 | 1 | 0.563 |
CAMK1A |
0.735 | -0.003 | -3 | 0.660 |
SLK |
0.735 | -0.014 | -2 | 0.725 |
PDHK3_TYR |
0.735 | 0.190 | 4 | 0.896 |
IRAK1 |
0.735 | -0.200 | -1 | 0.750 |
TAK1 |
0.734 | -0.080 | 1 | 0.624 |
EEF2K |
0.734 | -0.094 | 3 | 0.785 |
CRIK |
0.732 | 0.071 | -3 | 0.711 |
DMPK1 |
0.732 | 0.053 | -3 | 0.767 |
LRRK2 |
0.732 | -0.106 | 2 | 0.277 |
MST1 |
0.732 | -0.051 | 1 | 0.605 |
NEK1 |
0.731 | -0.076 | 1 | 0.564 |
VRK1 |
0.729 | -0.150 | 2 | 0.243 |
PKG1 |
0.728 | -0.003 | -2 | 0.637 |
ROCK1 |
0.728 | 0.025 | -3 | 0.762 |
YSK1 |
0.727 | -0.096 | 2 | 0.260 |
PDHK4_TYR |
0.727 | 0.094 | 2 | 0.312 |
TESK1_TYR |
0.727 | 0.083 | 3 | 0.858 |
MEK2 |
0.727 | -0.134 | 2 | 0.276 |
SBK |
0.727 | 0.007 | -3 | 0.577 |
CK1A |
0.727 | 0.058 | -3 | 0.483 |
LIMK2_TYR |
0.723 | 0.095 | -3 | 0.906 |
HASPIN |
0.723 | -0.005 | -1 | 0.740 |
MAP2K4_TYR |
0.722 | 0.084 | -1 | 0.855 |
MAP2K6_TYR |
0.722 | 0.051 | -1 | 0.858 |
OSR1 |
0.722 | -0.054 | 2 | 0.263 |
TTK |
0.722 | -0.036 | -2 | 0.755 |
PDHK1_TYR |
0.721 | 0.068 | -1 | 0.867 |
TXK |
0.720 | 0.165 | 1 | 0.768 |
PKMYT1_TYR |
0.719 | 0.014 | 3 | 0.827 |
MYO3B |
0.719 | -0.037 | 2 | 0.303 |
BMPR2_TYR |
0.718 | 0.051 | -1 | 0.833 |
RIPK2 |
0.718 | -0.209 | 1 | 0.538 |
MAP2K7_TYR |
0.717 | -0.119 | 2 | 0.290 |
ASK1 |
0.717 | -0.104 | 1 | 0.541 |
NEK3 |
0.716 | -0.133 | 1 | 0.505 |
EPHB4 |
0.716 | 0.020 | -1 | 0.803 |
EPHA6 |
0.715 | -0.015 | -1 | 0.822 |
MYO3A |
0.715 | -0.058 | 1 | 0.573 |
BIKE |
0.714 | -0.036 | 1 | 0.521 |
PINK1_TYR |
0.713 | -0.121 | 1 | 0.628 |
TNK2 |
0.712 | 0.044 | 3 | 0.752 |
RET |
0.711 | -0.071 | 1 | 0.566 |
TAO1 |
0.710 | -0.092 | 1 | 0.513 |
ALPHAK3 |
0.710 | -0.058 | -1 | 0.736 |
ROS1 |
0.710 | -0.031 | 3 | 0.735 |
LIMK1_TYR |
0.709 | -0.089 | 2 | 0.299 |
TYRO3 |
0.709 | -0.072 | 3 | 0.764 |
EPHA4 |
0.709 | -0.023 | 2 | 0.237 |
YANK2 |
0.709 | -0.047 | 2 | 0.122 |
ABL2 |
0.708 | 0.011 | -1 | 0.783 |
FGR |
0.707 | -0.007 | 1 | 0.664 |
INSRR |
0.706 | -0.007 | 3 | 0.720 |
SRMS |
0.706 | 0.009 | 1 | 0.711 |
MST1R |
0.706 | -0.087 | 3 | 0.788 |
CSF1R |
0.706 | -0.056 | 3 | 0.764 |
MERTK |
0.705 | 0.004 | 3 | 0.760 |
YES1 |
0.705 | -0.029 | -1 | 0.835 |
ITK |
0.704 | 0.013 | -1 | 0.763 |
ABL1 |
0.704 | -0.016 | -1 | 0.779 |
PTK2B |
0.704 | 0.065 | -1 | 0.760 |
EPHB1 |
0.704 | -0.002 | 1 | 0.686 |
NEK10_TYR |
0.704 | 0.008 | 1 | 0.468 |
FER |
0.704 | -0.036 | 1 | 0.686 |
TYK2 |
0.703 | -0.132 | 1 | 0.552 |
JAK3 |
0.703 | -0.068 | 1 | 0.562 |
AXL |
0.703 | -0.034 | 3 | 0.762 |
AAK1 |
0.703 | -0.008 | 1 | 0.435 |
STLK3 |
0.702 | -0.134 | 1 | 0.554 |
TNK1 |
0.702 | -0.043 | 3 | 0.749 |
JAK1 |
0.702 | 0.028 | 1 | 0.515 |
DDR1 |
0.702 | -0.123 | 4 | 0.807 |
EPHB2 |
0.702 | -0.023 | -1 | 0.779 |
JAK2 |
0.702 | -0.109 | 1 | 0.545 |
PDGFRB |
0.702 | -0.091 | 3 | 0.774 |
EPHB3 |
0.701 | -0.045 | -1 | 0.787 |
LCK |
0.700 | 0.024 | -1 | 0.795 |
BLK |
0.699 | 0.019 | -1 | 0.802 |
PTK2 |
0.699 | 0.066 | -1 | 0.739 |
FGFR2 |
0.699 | -0.124 | 3 | 0.779 |
BMX |
0.699 | 0.015 | -1 | 0.684 |
TNNI3K_TYR |
0.698 | -0.073 | 1 | 0.536 |
EPHA7 |
0.698 | -0.027 | 2 | 0.235 |
MET |
0.697 | -0.026 | 3 | 0.768 |
HCK |
0.697 | -0.054 | -1 | 0.795 |
KIT |
0.696 | -0.078 | 3 | 0.766 |
ALK |
0.696 | -0.038 | 3 | 0.679 |
KDR |
0.695 | -0.097 | 3 | 0.739 |
FGFR1 |
0.695 | -0.129 | 3 | 0.746 |
EPHA3 |
0.694 | -0.080 | 2 | 0.230 |
TEC |
0.694 | -0.022 | -1 | 0.711 |
PDGFRA |
0.693 | -0.128 | 3 | 0.764 |
FYN |
0.692 | -0.013 | -1 | 0.779 |
NTRK1 |
0.692 | -0.087 | -1 | 0.797 |
TEK |
0.692 | -0.135 | 3 | 0.703 |
LTK |
0.692 | -0.090 | 3 | 0.707 |
EPHA1 |
0.691 | -0.079 | 3 | 0.749 |
DDR2 |
0.691 | -0.042 | 3 | 0.710 |
PTK6 |
0.691 | -0.080 | -1 | 0.706 |
EPHA5 |
0.690 | -0.057 | 2 | 0.223 |
INSR |
0.689 | -0.074 | 3 | 0.699 |
FLT3 |
0.689 | -0.153 | 3 | 0.764 |
ERBB2 |
0.688 | -0.106 | 1 | 0.589 |
EPHA8 |
0.688 | -0.035 | -1 | 0.763 |
FGFR3 |
0.688 | -0.129 | 3 | 0.753 |
NTRK3 |
0.688 | -0.039 | -1 | 0.753 |
WEE1_TYR |
0.687 | -0.097 | -1 | 0.727 |
NTRK2 |
0.686 | -0.107 | 3 | 0.730 |
FRK |
0.686 | -0.092 | -1 | 0.802 |
BTK |
0.686 | -0.134 | -1 | 0.740 |
FLT1 |
0.685 | -0.115 | -1 | 0.788 |
MATK |
0.685 | -0.064 | -1 | 0.717 |
CK1G3 |
0.685 | -0.032 | -3 | 0.433 |
EGFR |
0.684 | -0.072 | 1 | 0.526 |
SYK |
0.683 | 0.014 | -1 | 0.726 |
SRC |
0.682 | -0.051 | -1 | 0.785 |
FLT4 |
0.682 | -0.163 | 3 | 0.726 |
CSK |
0.681 | -0.097 | 2 | 0.236 |
LYN |
0.680 | -0.080 | 3 | 0.682 |
EPHA2 |
0.680 | -0.050 | -1 | 0.722 |
FGFR4 |
0.677 | -0.095 | -1 | 0.734 |
ERBB4 |
0.677 | -0.032 | 1 | 0.591 |
IGF1R |
0.676 | -0.072 | 3 | 0.636 |
MUSK |
0.671 | -0.109 | 1 | 0.512 |
FES |
0.671 | -0.010 | -1 | 0.672 |
CK1G2 |
0.666 | -0.029 | -3 | 0.527 |
ZAP70 |
0.664 | -0.019 | -1 | 0.653 |