Motif 38 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B7ZBB8 | PPP1R3G | S84 | ochoa | Protein phosphatase 1 regulatory subunit 3G | Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity). {ECO:0000250}. |
| B7ZBB8 | PPP1R3G | S86 | ochoa | Protein phosphatase 1 regulatory subunit 3G | Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity). {ECO:0000250}. |
| O00287 | RFXAP | S237 | ochoa | Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) | Part of the RFX complex that binds to the X-box of MHC II promoters. |
| O00287 | RFXAP | S241 | ochoa | Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) | Part of the RFX complex that binds to the X-box of MHC II promoters. |
| O14497 | ARID1A | S1320 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14497 | ARID1A | S1322 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14497 | ARID1A | S1350 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14497 | ARID1A | S1352 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14646 | CHD1 | S90 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14686 | KMT2D | T3983 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S3986 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S4215 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14893 | GEMIN2 | S87 | ochoa | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}. |
| O14965 | AURKA | S66 | ochoa | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| O14994 | SYN3 | S462 | ochoa | Synapsin-3 (Synapsin III) | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
| O15400 | STX7 | T41 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O15400 | STX7 | S45 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O43752 | STX6 | S152 | ochoa | Syntaxin-6 | SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}. |
| O60885 | BRD4 | S1070 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O60885 | BRD4 | S1074 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75420 | GIGYF1 | T595 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O75449 | KATNA1 | S42 | psp | Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}. |
| O75791 | GRAP2 | S187 | ochoa | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
| O75791 | GRAP2 | Y207 | ochoa | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
| O94916 | NFAT5 | S1197 | psp | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O94916 | NFAT5 | S1247 | psp | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O94967 | WDR47 | S422 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95235 | KIF20A | S825 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95817 | BAG3 | S224 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P07476 | IVL | Y98 | ochoa | Involucrin | Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. |
| P08047 | SP1 | S376 | ochoa | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08047 | SP1 | S379 | ochoa | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P10275 | AR | S83 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P14859 | POU2F1 | S78 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14859 | POU2F1 | S81 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14859 | POU2F1 | S85 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14859 | POU2F1 | T162 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14859 | POU2F1 | S167 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14859 | POU2F1 | S232 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P35568 | IRS1 | S862 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35637 | FUS | T19 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P35637 | FUS | S26 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P35637 | FUS | S131 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P35637 | FUS | S142 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P42858 | HTT | S16 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46937 | YAP1 | S289 | ochoa|psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P46937 | YAP1 | S300 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P48634 | PRRC2A | Y636 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49116 | NR2C2 | S19 | ochoa | Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}. |
| P52333 | JAK3 | S493 | ochoa | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}. |
| P54253 | ATXN1 | S238 | ochoa|psp | Ataxin-1 (Spinocerebellar ataxia type 1 protein) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}. |
| P56524 | HDAC4 | S467 | ochoa|psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P56524 | HDAC4 | S584 | psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P78344 | EIF4G2 | S436 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| Q01196 | RUNX1 | S229 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q02078 | MEF2A | S408 | ochoa|psp | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q09472 | EP300 | S2279 | psp | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q12906 | ILF3 | S744 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13950 | RUNX2 | S43 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14847 | LASP1 | S167 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q15714 | TSC22D1 | S1047 | ochoa | TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}. |
| Q5T6F2 | UBAP2 | S427 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q5T6F2 | UBAP2 | S432 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q5VZK9 | CARMIL1 | S1324 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q6N021 | TET2 | S1518 | ochoa | Methylcytosine dioxygenase TET2 (EC 1.14.11.80) | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}. |
| Q6VY07 | PACS1 | S28 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6Y7W6 | GIGYF2 | S649 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q6Y7W6 | GIGYF2 | S650 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q6ZTU2 | EP400P1 | S106 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q7Z5Q1 | CPEB2 | S89 | ochoa | Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) | May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}. |
| Q7Z5Q1 | CPEB2 | S92 | ochoa | Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) | May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}. |
| Q86UP2 | KTN1 | S1325 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86VM9 | ZC3H18 | S791 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8IVH2 | FOXP4 | S57 | ochoa | Forkhead box protein P4 (Fork head-related protein-like A) | Transcriptional repressor that represses lung-specific expression. {ECO:0000250}. |
| Q8IZD4 | DCP1B | S444 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8N4C8 | MINK1 | Y475 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N4C8 | MINK1 | S478 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NDX5 | PHC3 | S315 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NDX5 | PHC3 | S318 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8TEW0 | PARD3 | S1196 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q92508 | PIEZO1 | S732 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92540 | SMG7 | S781 | ochoa | Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}. |
| Q92734 | TFG | Y247 | psp | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
| Q92786 | PROX1 | S199 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92973 | TNPO1 | S30 | ochoa | Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975}. |
| Q96BD5 | PHF21A | S80 | ochoa | PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269|PubMed:16140033}. |
| Q96KR1 | ZFR | S195 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96L91 | EP400 | S117 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9BWQ6 | YIPF2 | S60 | ochoa | Protein YIPF2 (YIP1 family member 2) | None |
| Q9H0E2 | TOLLIP | T25 | ochoa | Toll-interacting protein | Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856). Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325). Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:26320582). {ECO:0000269|PubMed:10854325, ECO:0000269|PubMed:11751856, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:25042851, ECO:0000269|PubMed:26320582}. |
| Q9H6I2 | SOX17 | S302 | ochoa | Transcription factor SOX-17 | Acts as a transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. {ECO:0000250|UniProtKB:Q61473}. |
| Q9HCJ0 | TNRC6C | S1314 | ochoa | Trinucleotide repeat-containing gene 6C protein | Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184, ECO:0000269|PubMed:21984185}. |
| Q9NSI6 | BRWD1 | S649 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NVH2 | INTS7 | Y935 | ochoa | Integrator complex subunit 7 (Int7) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q9P0J7 | KCMF1 | S219 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P0J7 | KCMF1 | S220 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P0J7 | KCMF1 | S223 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P0J7 | KCMF1 | S225 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P0K7 | RAI14 | S915 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0U4 | CXXC1 | S142 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9P0U4 | CXXC1 | S143 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9UBW7 | ZMYM2 | S305 | ochoa|psp | Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) | Involved in the negative regulation of transcription. {ECO:0000269|PubMed:32891193}. |
| Q9UEY8 | ADD3 | S585 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UI08 | EVL | S130 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UIF8 | BAZ2B | S335 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UIF9 | BAZ2A | S1214 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UJ78 | ZMYM5 | S218 | ochoa | Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) | Functions as a transcriptional regulator. {ECO:0000269|PubMed:17126306}. |
| Q9UJF2 | RASAL2 | S925 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UJF2 | RASAL2 | S928 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKV0 | HDAC9 | S451 | ochoa|psp | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9ULU4 | ZMYND8 | S829 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULV3 | CIZ1 | S332 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9ULV3 | CIZ1 | T347 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9ULV3 | CIZ1 | S350 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UPN9 | TRIM33 | T505 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UPN9 | TRIM33 | Y524 | psp | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UQL6 | HDAC5 | S498 | ochoa|psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9UQL6 | HDAC5 | S499 | ochoa | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9Y5Y5 | PEX16 | S183 | ochoa | Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16) | Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:12223482, ECO:0000269|PubMed:16717127}. |
| Q9Y6Q9 | NCOA3 | S967 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9Y520 | PRRC2C | S661 | EPSD|PSP | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q7Z5J4 | RAI1 | Y305 | Sugiyama | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q99504 | EYA3 | Y90 | PSP | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| Q9H0K1 | SIK2 | S707 | Sugiyama | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.000001 | 5.975 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.000010 | 4.989 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.000016 | 4.790 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.000017 | 4.778 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.000012 | 4.919 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000007 | 5.163 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.000035 | 4.452 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.000062 | 4.210 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.000063 | 4.202 |
| R-HSA-8939211 | ESR-mediated signaling | 0.000063 | 4.198 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.000089 | 4.049 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.000097 | 4.013 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.000151 | 3.822 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.000185 | 3.732 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000242 | 3.617 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.000261 | 3.583 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.000350 | 3.456 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.000628 | 3.202 |
| R-HSA-9839394 | TGFBR3 expression | 0.001252 | 2.902 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.001202 | 2.920 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.001202 | 2.920 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.001202 | 2.920 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.001202 | 2.920 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000936 | 3.029 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.001202 | 2.920 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.000912 | 3.040 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.001148 | 2.940 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.001371 | 2.863 |
| R-HSA-212436 | Generic Transcription Pathway | 0.001675 | 2.776 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.001800 | 2.745 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.001768 | 2.753 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.002399 | 2.620 |
| R-HSA-2559583 | Cellular Senescence | 0.002331 | 2.633 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.002579 | 2.589 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.003045 | 2.516 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.003558 | 2.449 |
| R-HSA-201556 | Signaling by ALK | 0.003806 | 2.420 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.004108 | 2.386 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.005979 | 2.223 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.005924 | 2.227 |
| R-HSA-9758941 | Gastrulation | 0.005536 | 2.257 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.006239 | 2.205 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.007290 | 2.137 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.007190 | 2.143 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.007403 | 2.131 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.007515 | 2.124 |
| R-HSA-157118 | Signaling by NOTCH | 0.008374 | 2.077 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.008567 | 2.067 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.008966 | 2.047 |
| R-HSA-4839726 | Chromatin organization | 0.009791 | 2.009 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.009399 | 2.027 |
| R-HSA-421270 | Cell-cell junction organization | 0.010128 | 1.994 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.011500 | 1.939 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.013449 | 1.871 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.012488 | 1.904 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.013850 | 1.859 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.013953 | 1.855 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.015248 | 1.817 |
| R-HSA-446728 | Cell junction organization | 0.015516 | 1.809 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.015912 | 1.798 |
| R-HSA-1474165 | Reproduction | 0.017200 | 1.764 |
| R-HSA-525793 | Myogenesis | 0.019851 | 1.702 |
| R-HSA-418990 | Adherens junctions interactions | 0.022499 | 1.648 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.024212 | 1.616 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.026474 | 1.577 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.026511 | 1.577 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.027278 | 1.564 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.028032 | 1.552 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.029083 | 1.536 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.028609 | 1.543 |
| R-HSA-1500931 | Cell-Cell communication | 0.026081 | 1.584 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.028167 | 1.550 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.032983 | 1.482 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.032983 | 1.482 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.030196 | 1.520 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.032755 | 1.485 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.032755 | 1.485 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.035641 | 1.448 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.035641 | 1.448 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.032755 | 1.485 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.039449 | 1.404 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.045873 | 1.338 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.045873 | 1.338 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.045873 | 1.338 |
| R-HSA-74713 | IRS activation | 0.045873 | 1.338 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.038622 | 1.413 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.045873 | 1.338 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.043695 | 1.360 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.043695 | 1.360 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.038622 | 1.413 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.041695 | 1.380 |
| R-HSA-202433 | Generation of second messenger molecules | 0.040148 | 1.396 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.042414 | 1.372 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.040225 | 1.396 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.038791 | 1.411 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.045873 | 1.338 |
| R-HSA-1266738 | Developmental Biology | 0.037585 | 1.425 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.040870 | 1.389 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.040870 | 1.389 |
| R-HSA-162582 | Signal Transduction | 0.045577 | 1.341 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.045563 | 1.341 |
| R-HSA-2262752 | Cellular responses to stress | 0.046064 | 1.337 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.046511 | 1.332 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.046511 | 1.332 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.052253 | 1.282 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.058592 | 1.232 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.058592 | 1.232 |
| R-HSA-112412 | SOS-mediated signalling | 0.064888 | 1.188 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.071143 | 1.148 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.077356 | 1.112 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.089659 | 1.047 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.101800 | 0.992 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.107810 | 0.967 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.119711 | 0.922 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.119711 | 0.922 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.119711 | 0.922 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.154478 | 0.811 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.154478 | 0.811 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.171348 | 0.766 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.176896 | 0.752 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.176896 | 0.752 |
| R-HSA-429947 | Deadenylation of mRNA | 0.182408 | 0.739 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.094867 | 1.023 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.113949 | 0.943 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.202388 | 0.694 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.202388 | 0.694 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.064888 | 1.188 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.125602 | 0.901 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.101800 | 0.992 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.077356 | 1.112 |
| R-HSA-198203 | PI3K/AKT activation | 0.083528 | 1.078 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.127172 | 0.896 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.068621 | 1.164 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.068621 | 1.164 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.071143 | 1.148 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.071143 | 1.148 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.107810 | 0.967 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.089659 | 1.047 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.068621 | 1.164 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.101800 | 0.992 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.113780 | 0.944 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.071143 | 1.148 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.193323 | 0.714 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.083528 | 1.078 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.113780 | 0.944 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.119711 | 0.922 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.095750 | 1.019 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.161624 | 0.791 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.095750 | 1.019 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.101800 | 0.992 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.107810 | 0.967 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.143043 | 0.845 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.143043 | 0.845 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.074925 | 1.125 |
| R-HSA-6807070 | PTEN Regulation | 0.088109 | 1.055 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.101800 | 0.992 |
| R-HSA-74749 | Signal attenuation | 0.083528 | 1.078 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.064888 | 1.188 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.171348 | 0.766 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.187884 | 0.726 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.187884 | 0.726 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.052405 | 1.281 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.148779 | 0.827 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.077356 | 1.112 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.131454 | 0.881 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.143043 | 0.845 |
| R-HSA-420029 | Tight junction interactions | 0.187884 | 0.726 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.162074 | 0.790 |
| R-HSA-9842663 | Signaling by LTK | 0.101800 | 0.992 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.060510 | 1.218 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.058592 | 1.232 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.131454 | 0.881 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.077356 | 1.112 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.095750 | 1.019 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.107810 | 0.967 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.125602 | 0.901 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.073013 | 1.137 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.192676 | 0.715 |
| R-HSA-2028269 | Signaling by Hippo | 0.137268 | 0.862 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.073013 | 1.137 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.101119 | 0.995 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.101800 | 0.992 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.137268 | 0.862 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.143043 | 0.845 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.160139 | 0.796 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.193323 | 0.714 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.076852 | 1.114 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.169227 | 0.772 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.080753 | 1.093 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.137268 | 0.862 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.182408 | 0.739 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.131454 | 0.881 |
| R-HSA-1181150 | Signaling by NODAL | 0.154478 | 0.811 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.193323 | 0.714 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.111782 | 0.952 |
| R-HSA-9707616 | Heme signaling | 0.080753 | 1.093 |
| R-HSA-449147 | Signaling by Interleukins | 0.069367 | 1.159 |
| R-HSA-202403 | TCR signaling | 0.197524 | 0.704 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.176896 | 0.752 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.064888 | 1.188 |
| R-HSA-198753 | ERK/MAPK targets | 0.160139 | 0.796 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.143043 | 0.845 |
| R-HSA-3214847 | HATs acetylate histones | 0.168708 | 0.773 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.171348 | 0.766 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.129411 | 0.888 |
| R-HSA-1989781 | PPARA activates gene expression | 0.111054 | 0.954 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.142164 | 0.847 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.160139 | 0.796 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.063508 | 1.197 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.113892 | 0.944 |
| R-HSA-2586552 | Signaling by Leptin | 0.083528 | 1.078 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.165762 | 0.781 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.101119 | 0.995 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.119711 | 0.922 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.148779 | 0.827 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.145327 | 0.838 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.176896 | 0.752 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.072109 | 1.142 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.154711 | 0.810 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.104082 | 0.983 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.180630 | 0.743 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.071118 | 1.148 |
| R-HSA-166520 | Signaling by NTRKs | 0.101344 | 0.994 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.207265 | 0.683 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.101399 | 0.994 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.125602 | 0.901 |
| R-HSA-9945266 | Differentiation of T cells | 0.125602 | 0.901 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.209425 | 0.679 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.107482 | 0.969 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.206222 | 0.686 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.109645 | 0.960 |
| R-HSA-195721 | Signaling by WNT | 0.165921 | 0.780 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.176896 | 0.752 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.133915 | 0.873 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.147633 | 0.831 |
| R-HSA-9679506 | SARS-CoV Infections | 0.093117 | 1.031 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.142164 | 0.847 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.214721 | 0.668 |
| R-HSA-2424491 | DAP12 signaling | 0.214721 | 0.668 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.214721 | 0.668 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.214721 | 0.668 |
| R-HSA-112311 | Neurotransmitter clearance | 0.214721 | 0.668 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.219982 | 0.658 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.225208 | 0.647 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.225735 | 0.646 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.229354 | 0.639 |
| R-HSA-3371556 | Cellular response to heat stress | 0.229354 | 0.639 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.230399 | 0.638 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.230399 | 0.638 |
| R-HSA-9930044 | Nuclear RNA decay | 0.230399 | 0.638 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.235556 | 0.628 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.235556 | 0.628 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.235556 | 0.628 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.240679 | 0.619 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.240679 | 0.619 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.245768 | 0.609 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.250822 | 0.601 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.250822 | 0.601 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.250822 | 0.601 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.250822 | 0.601 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.252886 | 0.597 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.255844 | 0.592 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.255844 | 0.592 |
| R-HSA-9843745 | Adipogenesis | 0.259029 | 0.587 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.260832 | 0.584 |
| R-HSA-9909396 | Circadian clock | 0.261507 | 0.583 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.265787 | 0.575 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.270708 | 0.567 |
| R-HSA-3371568 | Attenuation phase | 0.270708 | 0.567 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.270708 | 0.567 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.270708 | 0.567 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.275598 | 0.560 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.275598 | 0.560 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.275598 | 0.560 |
| R-HSA-9607240 | FLT3 Signaling | 0.275598 | 0.560 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.280454 | 0.552 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.280454 | 0.552 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.280454 | 0.552 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.281335 | 0.551 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.285279 | 0.545 |
| R-HSA-165159 | MTOR signalling | 0.285279 | 0.545 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.290071 | 0.537 |
| R-HSA-2172127 | DAP12 interactions | 0.294832 | 0.530 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.294832 | 0.530 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.294832 | 0.530 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.299561 | 0.524 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.308925 | 0.510 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.310992 | 0.507 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.313454 | 0.504 |
| R-HSA-5620924 | Intraflagellar transport | 0.313560 | 0.504 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.313560 | 0.504 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.313560 | 0.504 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.313560 | 0.504 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.322739 | 0.491 |
| R-HSA-109704 | PI3K Cascade | 0.322739 | 0.491 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.327282 | 0.485 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.331796 | 0.479 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.331796 | 0.479 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.335524 | 0.474 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.336279 | 0.473 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.336279 | 0.473 |
| R-HSA-72649 | Translation initiation complex formation | 0.340732 | 0.468 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.340732 | 0.468 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.343097 | 0.465 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.345156 | 0.462 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.345156 | 0.462 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.349551 | 0.456 |
| R-HSA-8953854 | Metabolism of RNA | 0.350995 | 0.455 |
| R-HSA-112399 | IRS-mediated signalling | 0.353916 | 0.451 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.355905 | 0.449 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.358252 | 0.446 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.362560 | 0.441 |
| R-HSA-191859 | snRNP Assembly | 0.362560 | 0.441 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.362560 | 0.441 |
| R-HSA-186712 | Regulation of beta-cell development | 0.362560 | 0.441 |
| R-HSA-9824446 | Viral Infection Pathways | 0.363941 | 0.439 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.366838 | 0.436 |
| R-HSA-983189 | Kinesins | 0.366838 | 0.436 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.366838 | 0.436 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.371089 | 0.431 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.371089 | 0.431 |
| R-HSA-450294 | MAP kinase activation | 0.371089 | 0.431 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.375311 | 0.426 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.379505 | 0.421 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.383671 | 0.416 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.383671 | 0.416 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.387809 | 0.411 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.387809 | 0.411 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.391920 | 0.407 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.396004 | 0.402 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.400060 | 0.398 |
| R-HSA-69275 | G2/M Transition | 0.400305 | 0.398 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.404995 | 0.393 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.408092 | 0.389 |
| R-HSA-448424 | Interleukin-17 signaling | 0.408092 | 0.389 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.408092 | 0.389 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.412067 | 0.385 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.412067 | 0.385 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.412067 | 0.385 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.412067 | 0.385 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.412067 | 0.385 |
| R-HSA-4086398 | Ca2+ pathway | 0.419940 | 0.377 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.423837 | 0.373 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.423837 | 0.373 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.423837 | 0.373 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.432761 | 0.364 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.439597 | 0.357 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.442936 | 0.354 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.446680 | 0.350 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.446680 | 0.350 |
| R-HSA-9833482 | PKR-mediated signaling | 0.446680 | 0.350 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.446680 | 0.350 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.461408 | 0.336 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.472199 | 0.326 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.486253 | 0.313 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.493141 | 0.307 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.496551 | 0.304 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.503301 | 0.298 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.506643 | 0.295 |
| R-HSA-913531 | Interferon Signaling | 0.510917 | 0.292 |
| R-HSA-168256 | Immune System | 0.512420 | 0.290 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.513260 | 0.290 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.519789 | 0.284 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.519789 | 0.284 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.519789 | 0.284 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.519789 | 0.284 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.523021 | 0.281 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.529420 | 0.276 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.532587 | 0.274 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.532587 | 0.274 |
| R-HSA-9833110 | RSV-host interactions | 0.541964 | 0.266 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.545048 | 0.264 |
| R-HSA-211000 | Gene Silencing by RNA | 0.551154 | 0.259 |
| R-HSA-5688426 | Deubiquitination | 0.552357 | 0.258 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.554177 | 0.256 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.554177 | 0.256 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.554177 | 0.256 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.557179 | 0.254 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.557564 | 0.254 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.560162 | 0.252 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.560162 | 0.252 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.566067 | 0.247 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.568990 | 0.245 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.574778 | 0.241 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.577507 | 0.238 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.577643 | 0.238 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.577643 | 0.238 |
| R-HSA-1280218 | Adaptive Immune System | 0.579086 | 0.237 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.580489 | 0.236 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.583315 | 0.234 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.583315 | 0.234 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.588913 | 0.230 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.591683 | 0.228 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.591683 | 0.228 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.599884 | 0.222 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.599884 | 0.222 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.602582 | 0.220 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.602582 | 0.220 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.605261 | 0.218 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.605261 | 0.218 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.623522 | 0.205 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.631089 | 0.200 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.636318 | 0.196 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.643368 | 0.192 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.645774 | 0.190 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.671210 | 0.173 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.672472 | 0.172 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.673430 | 0.172 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.682164 | 0.166 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.682164 | 0.166 |
| R-HSA-9609507 | Protein localization | 0.684312 | 0.165 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.684312 | 0.165 |
| R-HSA-9610379 | HCMV Late Events | 0.692758 | 0.159 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.722483 | 0.141 |
| R-HSA-1640170 | Cell Cycle | 0.725496 | 0.139 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.726225 | 0.139 |
| R-HSA-1643685 | Disease | 0.742152 | 0.130 |
| R-HSA-68886 | M Phase | 0.755754 | 0.122 |
| R-HSA-5617833 | Cilium Assembly | 0.756077 | 0.121 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.757729 | 0.120 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.762618 | 0.118 |
| R-HSA-9609690 | HCMV Early Events | 0.765823 | 0.116 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.773525 | 0.112 |
| R-HSA-9675108 | Nervous system development | 0.773874 | 0.111 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.775184 | 0.111 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.776708 | 0.110 |
| R-HSA-72172 | mRNA Splicing | 0.779724 | 0.108 |
| R-HSA-6805567 | Keratinization | 0.782701 | 0.106 |
| R-HSA-68882 | Mitotic Anaphase | 0.796995 | 0.099 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.798372 | 0.098 |
| R-HSA-162906 | HIV Infection | 0.811644 | 0.091 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.812923 | 0.090 |
| R-HSA-5663205 | Infectious disease | 0.823017 | 0.085 |
| R-HSA-199991 | Membrane Trafficking | 0.830873 | 0.080 |
| R-HSA-6798695 | Neutrophil degranulation | 0.833852 | 0.079 |
| R-HSA-9609646 | HCMV Infection | 0.838975 | 0.076 |
| R-HSA-112316 | Neuronal System | 0.843215 | 0.074 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.867899 | 0.062 |
| R-HSA-422475 | Axon guidance | 0.896498 | 0.047 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.900215 | 0.046 |
| R-HSA-8957322 | Metabolism of steroids | 0.902913 | 0.044 |
| R-HSA-109582 | Hemostasis | 0.910814 | 0.041 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.918211 | 0.037 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.920741 | 0.036 |
| R-HSA-73894 | DNA Repair | 0.924161 | 0.034 |
| R-HSA-597592 | Post-translational protein modification | 0.941779 | 0.026 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.950844 | 0.022 |
| R-HSA-72766 | Translation | 0.953161 | 0.021 |
| R-HSA-168249 | Innate Immune System | 0.953755 | 0.021 |
| R-HSA-382551 | Transport of small molecules | 0.967410 | 0.014 |
| R-HSA-392499 | Metabolism of proteins | 0.994838 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.998206 | 0.001 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.840 | 0.486 | 1 | 0.807 |
HIPK4 |
0.839 | 0.389 | 1 | 0.777 |
CDK7 |
0.838 | 0.463 | 1 | 0.829 |
HIPK2 |
0.837 | 0.482 | 1 | 0.795 |
CLK3 |
0.835 | 0.348 | 1 | 0.783 |
NLK |
0.835 | 0.433 | 1 | 0.801 |
CDK19 |
0.833 | 0.454 | 1 | 0.808 |
JNK2 |
0.833 | 0.486 | 1 | 0.809 |
CDK8 |
0.832 | 0.445 | 1 | 0.815 |
DYRK2 |
0.832 | 0.449 | 1 | 0.818 |
KIS |
0.831 | 0.426 | 1 | 0.824 |
CDK17 |
0.831 | 0.465 | 1 | 0.778 |
P38B |
0.830 | 0.473 | 1 | 0.816 |
PRKD1 |
0.830 | 0.237 | -3 | 0.847 |
ERK5 |
0.829 | 0.284 | 1 | 0.770 |
ICK |
0.829 | 0.327 | -3 | 0.854 |
HIPK1 |
0.828 | 0.437 | 1 | 0.818 |
CDK16 |
0.828 | 0.464 | 1 | 0.788 |
ERK1 |
0.827 | 0.449 | 1 | 0.817 |
CDK5 |
0.827 | 0.426 | 1 | 0.832 |
SRPK1 |
0.827 | 0.265 | -3 | 0.788 |
P38A |
0.827 | 0.453 | 1 | 0.829 |
P38G |
0.826 | 0.460 | 1 | 0.777 |
COT |
0.825 | 0.073 | 2 | 0.798 |
P38D |
0.825 | 0.479 | 1 | 0.825 |
PIM3 |
0.825 | 0.149 | -3 | 0.857 |
CDK14 |
0.824 | 0.453 | 1 | 0.815 |
CDK13 |
0.824 | 0.415 | 1 | 0.821 |
CDKL5 |
0.824 | 0.207 | -3 | 0.820 |
CDK1 |
0.824 | 0.424 | 1 | 0.808 |
PRKD2 |
0.824 | 0.209 | -3 | 0.798 |
JNK3 |
0.823 | 0.452 | 1 | 0.819 |
CDKL1 |
0.823 | 0.193 | -3 | 0.826 |
ATR |
0.823 | 0.243 | 1 | 0.752 |
CDK9 |
0.821 | 0.414 | 1 | 0.824 |
NDR2 |
0.821 | 0.118 | -3 | 0.856 |
CDK12 |
0.821 | 0.418 | 1 | 0.809 |
DYRK1A |
0.820 | 0.392 | 1 | 0.816 |
ERK2 |
0.820 | 0.429 | 1 | 0.819 |
CDK3 |
0.820 | 0.394 | 1 | 0.791 |
CDK10 |
0.820 | 0.430 | 1 | 0.814 |
DYRK4 |
0.820 | 0.434 | 1 | 0.810 |
PIM1 |
0.819 | 0.178 | -3 | 0.811 |
SRPK2 |
0.817 | 0.228 | -3 | 0.719 |
CLK4 |
0.817 | 0.281 | -3 | 0.778 |
HIPK3 |
0.816 | 0.404 | 1 | 0.795 |
MTOR |
0.816 | 0.074 | 1 | 0.683 |
DYRK1B |
0.815 | 0.413 | 1 | 0.801 |
CLK1 |
0.814 | 0.291 | -3 | 0.753 |
P90RSK |
0.814 | 0.124 | -3 | 0.801 |
CLK2 |
0.814 | 0.307 | -3 | 0.778 |
CDC7 |
0.814 | -0.027 | 1 | 0.622 |
SKMLCK |
0.813 | 0.093 | -2 | 0.852 |
PRPK |
0.812 | -0.074 | -1 | 0.823 |
MAK |
0.812 | 0.383 | -2 | 0.776 |
MOS |
0.812 | -0.006 | 1 | 0.647 |
CAMK1B |
0.812 | 0.059 | -3 | 0.853 |
RSK2 |
0.812 | 0.109 | -3 | 0.797 |
NDR1 |
0.811 | 0.060 | -3 | 0.844 |
TBK1 |
0.810 | -0.056 | 1 | 0.532 |
AURC |
0.810 | 0.125 | -2 | 0.684 |
CDK2 |
0.810 | 0.310 | 1 | 0.804 |
DYRK3 |
0.809 | 0.345 | 1 | 0.800 |
MAPKAPK3 |
0.809 | 0.113 | -3 | 0.799 |
LATS2 |
0.809 | 0.069 | -5 | 0.728 |
PKN3 |
0.808 | 0.041 | -3 | 0.832 |
MLK2 |
0.808 | 0.080 | 2 | 0.775 |
MAPKAPK2 |
0.808 | 0.133 | -3 | 0.774 |
NIK |
0.808 | 0.041 | -3 | 0.864 |
PKCD |
0.808 | 0.083 | 2 | 0.729 |
CHAK2 |
0.808 | 0.053 | -1 | 0.836 |
DAPK2 |
0.808 | 0.090 | -3 | 0.857 |
RAF1 |
0.808 | -0.098 | 1 | 0.609 |
RSK3 |
0.807 | 0.081 | -3 | 0.791 |
CAMLCK |
0.807 | 0.062 | -2 | 0.845 |
DNAPK |
0.806 | 0.204 | 1 | 0.731 |
SMG1 |
0.806 | 0.201 | 1 | 0.749 |
BMPR2 |
0.805 | -0.134 | -2 | 0.845 |
CDK6 |
0.805 | 0.398 | 1 | 0.812 |
SRPK3 |
0.805 | 0.168 | -3 | 0.761 |
PDHK4 |
0.805 | -0.180 | 1 | 0.653 |
PRKD3 |
0.805 | 0.122 | -3 | 0.758 |
CAMK2D |
0.804 | 0.037 | -3 | 0.838 |
PKACG |
0.804 | 0.067 | -2 | 0.756 |
CDK4 |
0.804 | 0.407 | 1 | 0.806 |
P70S6KB |
0.804 | 0.077 | -3 | 0.806 |
MOK |
0.804 | 0.342 | 1 | 0.797 |
AMPKA1 |
0.804 | 0.036 | -3 | 0.851 |
IKKE |
0.803 | -0.103 | 1 | 0.526 |
JNK1 |
0.803 | 0.393 | 1 | 0.799 |
TGFBR2 |
0.803 | -0.026 | -2 | 0.739 |
ULK2 |
0.802 | -0.131 | 2 | 0.715 |
RIPK3 |
0.802 | -0.068 | 3 | 0.686 |
PKACB |
0.802 | 0.134 | -2 | 0.696 |
ATM |
0.801 | 0.144 | 1 | 0.735 |
AMPKA2 |
0.801 | 0.060 | -3 | 0.828 |
LATS1 |
0.801 | 0.090 | -3 | 0.865 |
MARK4 |
0.801 | 0.007 | 4 | 0.794 |
PRP4 |
0.801 | 0.267 | -3 | 0.772 |
GCN2 |
0.801 | -0.164 | 2 | 0.714 |
TSSK1 |
0.800 | 0.056 | -3 | 0.870 |
IKKB |
0.800 | -0.129 | -2 | 0.708 |
MST4 |
0.800 | -0.024 | 2 | 0.793 |
AURB |
0.800 | 0.089 | -2 | 0.681 |
MNK2 |
0.799 | 0.062 | -2 | 0.798 |
DSTYK |
0.799 | -0.112 | 2 | 0.802 |
PKN2 |
0.799 | -0.006 | -3 | 0.833 |
PKCB |
0.799 | 0.057 | 2 | 0.676 |
WNK1 |
0.799 | -0.060 | -2 | 0.868 |
MASTL |
0.799 | -0.120 | -2 | 0.788 |
NUAK2 |
0.798 | 0.004 | -3 | 0.838 |
CAMK2B |
0.798 | 0.058 | 2 | 0.701 |
PAK1 |
0.798 | 0.042 | -2 | 0.796 |
PIM2 |
0.798 | 0.122 | -3 | 0.761 |
IKKA |
0.798 | -0.036 | -2 | 0.696 |
NEK6 |
0.798 | -0.063 | -2 | 0.803 |
RSK4 |
0.798 | 0.100 | -3 | 0.776 |
PAK3 |
0.797 | 0.026 | -2 | 0.794 |
PDHK1 |
0.797 | -0.197 | 1 | 0.631 |
MELK |
0.797 | 0.039 | -3 | 0.807 |
PKG2 |
0.796 | 0.086 | -2 | 0.697 |
PKCA |
0.796 | 0.047 | 2 | 0.676 |
MSK2 |
0.796 | 0.058 | -3 | 0.780 |
IRE2 |
0.796 | -0.009 | 2 | 0.689 |
PHKG1 |
0.796 | 0.013 | -3 | 0.833 |
TSSK2 |
0.796 | 0.007 | -5 | 0.775 |
CAMK2G |
0.796 | -0.140 | 2 | 0.710 |
NIM1 |
0.795 | -0.016 | 3 | 0.701 |
MSK1 |
0.795 | 0.082 | -3 | 0.781 |
PKCZ |
0.795 | 0.025 | 2 | 0.714 |
AKT2 |
0.795 | 0.113 | -3 | 0.713 |
NEK9 |
0.795 | -0.119 | 2 | 0.757 |
CAMK2A |
0.794 | 0.050 | 2 | 0.696 |
DLK |
0.794 | -0.123 | 1 | 0.596 |
MLK1 |
0.794 | -0.141 | 2 | 0.747 |
ERK7 |
0.794 | 0.136 | 2 | 0.491 |
MNK1 |
0.793 | 0.053 | -2 | 0.801 |
NEK7 |
0.793 | -0.166 | -3 | 0.810 |
CAMK4 |
0.793 | -0.020 | -3 | 0.812 |
CHK1 |
0.792 | 0.059 | -3 | 0.833 |
NUAK1 |
0.792 | 0.034 | -3 | 0.795 |
VRK2 |
0.792 | -0.014 | 1 | 0.683 |
WNK3 |
0.791 | -0.190 | 1 | 0.603 |
ULK1 |
0.791 | -0.144 | -3 | 0.784 |
MPSK1 |
0.791 | 0.111 | 1 | 0.617 |
MLK3 |
0.791 | -0.051 | 2 | 0.687 |
PKR |
0.791 | -0.048 | 1 | 0.619 |
IRE1 |
0.791 | -0.092 | 1 | 0.583 |
CHAK1 |
0.791 | -0.035 | 2 | 0.739 |
HUNK |
0.791 | -0.167 | 2 | 0.702 |
PKCG |
0.791 | 0.004 | 2 | 0.672 |
ANKRD3 |
0.790 | -0.154 | 1 | 0.636 |
GRK5 |
0.790 | -0.193 | -3 | 0.823 |
PRKX |
0.790 | 0.127 | -3 | 0.704 |
QSK |
0.789 | 0.031 | 4 | 0.776 |
SGK3 |
0.789 | 0.058 | -3 | 0.774 |
PAK2 |
0.789 | 0.001 | -2 | 0.780 |
ALK4 |
0.789 | -0.053 | -2 | 0.785 |
GRK1 |
0.788 | -0.045 | -2 | 0.749 |
RIPK1 |
0.788 | -0.173 | 1 | 0.592 |
DCAMKL1 |
0.788 | 0.041 | -3 | 0.797 |
BCKDK |
0.788 | -0.168 | -1 | 0.771 |
SIK |
0.788 | 0.046 | -3 | 0.769 |
MYLK4 |
0.787 | 0.036 | -2 | 0.778 |
TLK2 |
0.787 | -0.013 | 1 | 0.617 |
BMPR1B |
0.787 | -0.023 | 1 | 0.552 |
YSK4 |
0.786 | -0.112 | 1 | 0.555 |
NEK2 |
0.786 | -0.086 | 2 | 0.737 |
TGFBR1 |
0.786 | -0.048 | -2 | 0.760 |
GSK3A |
0.785 | 0.131 | 4 | 0.443 |
PKCH |
0.785 | -0.026 | 2 | 0.658 |
NEK5 |
0.784 | -0.020 | 1 | 0.629 |
BUB1 |
0.784 | 0.163 | -5 | 0.764 |
AKT1 |
0.784 | 0.094 | -3 | 0.730 |
PKACA |
0.784 | 0.098 | -2 | 0.653 |
MEK1 |
0.784 | -0.172 | 2 | 0.763 |
QIK |
0.784 | -0.063 | -3 | 0.812 |
IRAK4 |
0.783 | -0.050 | 1 | 0.586 |
MLK4 |
0.783 | -0.092 | 2 | 0.671 |
GRK6 |
0.783 | -0.170 | 1 | 0.589 |
LKB1 |
0.783 | 0.081 | -3 | 0.811 |
PAK6 |
0.782 | 0.018 | -2 | 0.725 |
MAPKAPK5 |
0.782 | 0.006 | -3 | 0.750 |
BRSK2 |
0.782 | -0.034 | -3 | 0.808 |
AURA |
0.782 | 0.032 | -2 | 0.655 |
BRSK1 |
0.782 | -0.009 | -3 | 0.800 |
FAM20C |
0.781 | 0.013 | 2 | 0.578 |
CAMK1G |
0.781 | 0.017 | -3 | 0.773 |
PKCT |
0.781 | 0.011 | 2 | 0.674 |
MARK2 |
0.780 | -0.005 | 4 | 0.698 |
PASK |
0.780 | 0.027 | -3 | 0.867 |
CAMK1D |
0.780 | 0.079 | -3 | 0.696 |
SMMLCK |
0.780 | 0.032 | -3 | 0.819 |
PINK1 |
0.780 | -0.003 | 1 | 0.709 |
DAPK3 |
0.780 | 0.089 | -3 | 0.811 |
GRK7 |
0.779 | -0.045 | 1 | 0.574 |
P70S6K |
0.779 | 0.045 | -3 | 0.728 |
MST3 |
0.778 | -0.046 | 2 | 0.761 |
DCAMKL2 |
0.778 | -0.011 | -3 | 0.806 |
MARK3 |
0.778 | -0.011 | 4 | 0.739 |
MEKK1 |
0.778 | -0.152 | 1 | 0.593 |
PLK1 |
0.777 | -0.174 | -2 | 0.742 |
GSK3B |
0.777 | 0.038 | 4 | 0.437 |
SSTK |
0.777 | 0.009 | 4 | 0.760 |
DRAK1 |
0.776 | -0.115 | 1 | 0.560 |
MEK5 |
0.776 | -0.195 | 2 | 0.756 |
ALK2 |
0.776 | -0.086 | -2 | 0.769 |
TAO3 |
0.776 | -0.049 | 1 | 0.590 |
AKT3 |
0.776 | 0.106 | -3 | 0.670 |
TTBK2 |
0.776 | -0.233 | 2 | 0.599 |
GRK4 |
0.776 | -0.211 | -2 | 0.767 |
SNRK |
0.775 | -0.114 | 2 | 0.610 |
ZAK |
0.775 | -0.153 | 1 | 0.554 |
SBK |
0.775 | 0.150 | -3 | 0.612 |
PLK4 |
0.775 | -0.127 | 2 | 0.549 |
ROCK2 |
0.775 | 0.097 | -3 | 0.795 |
ACVR2A |
0.775 | -0.100 | -2 | 0.723 |
BRAF |
0.774 | -0.120 | -4 | 0.737 |
MEKK2 |
0.774 | -0.128 | 2 | 0.741 |
ACVR2B |
0.774 | -0.101 | -2 | 0.733 |
PERK |
0.774 | -0.161 | -2 | 0.776 |
MEKK6 |
0.773 | -0.036 | 1 | 0.593 |
GAK |
0.773 | 0.009 | 1 | 0.663 |
WNK4 |
0.773 | -0.136 | -2 | 0.857 |
SGK1 |
0.773 | 0.098 | -3 | 0.652 |
CAMK1A |
0.773 | 0.093 | -3 | 0.685 |
PKCI |
0.772 | -0.027 | 2 | 0.679 |
NEK11 |
0.772 | -0.119 | 1 | 0.587 |
MARK1 |
0.772 | -0.047 | 4 | 0.756 |
MAP3K15 |
0.772 | -0.038 | 1 | 0.560 |
MRCKA |
0.772 | 0.079 | -3 | 0.762 |
GCK |
0.772 | -0.015 | 1 | 0.586 |
NEK4 |
0.771 | -0.054 | 1 | 0.584 |
PBK |
0.771 | 0.057 | 1 | 0.616 |
PAK5 |
0.771 | 0.013 | -2 | 0.668 |
HRI |
0.770 | -0.205 | -2 | 0.795 |
MRCKB |
0.770 | 0.072 | -3 | 0.747 |
LOK |
0.770 | -0.004 | -2 | 0.755 |
CAMKK2 |
0.770 | -0.047 | -2 | 0.752 |
PKCE |
0.770 | 0.013 | 2 | 0.660 |
CHK2 |
0.770 | 0.063 | -3 | 0.661 |
PHKG2 |
0.769 | -0.056 | -3 | 0.786 |
TAO2 |
0.769 | -0.085 | 2 | 0.773 |
KHS1 |
0.769 | 0.027 | 1 | 0.578 |
HGK |
0.769 | -0.032 | 3 | 0.787 |
PDK1 |
0.769 | -0.064 | 1 | 0.597 |
TNIK |
0.769 | -0.009 | 3 | 0.788 |
PAK4 |
0.768 | 0.017 | -2 | 0.679 |
CAMKK1 |
0.768 | -0.105 | -2 | 0.751 |
MST2 |
0.768 | -0.058 | 1 | 0.586 |
BMPR1A |
0.768 | -0.058 | 1 | 0.526 |
DAPK1 |
0.768 | 0.042 | -3 | 0.796 |
PLK3 |
0.768 | -0.168 | 2 | 0.657 |
NEK8 |
0.768 | -0.136 | 2 | 0.740 |
DMPK1 |
0.767 | 0.110 | -3 | 0.768 |
GRK2 |
0.767 | -0.126 | -2 | 0.668 |
PKN1 |
0.767 | 0.009 | -3 | 0.736 |
TLK1 |
0.766 | -0.138 | -2 | 0.766 |
CRIK |
0.766 | 0.110 | -3 | 0.737 |
NEK1 |
0.766 | -0.065 | 1 | 0.582 |
MINK |
0.765 | -0.077 | 1 | 0.572 |
KHS2 |
0.765 | 0.016 | 1 | 0.594 |
HPK1 |
0.764 | -0.055 | 1 | 0.580 |
CK1E |
0.763 | -0.056 | -3 | 0.542 |
MEKK3 |
0.763 | -0.265 | 1 | 0.578 |
LRRK2 |
0.763 | -0.091 | 2 | 0.754 |
VRK1 |
0.763 | -0.071 | 2 | 0.759 |
MST1 |
0.762 | -0.047 | 1 | 0.567 |
EEF2K |
0.762 | -0.086 | 3 | 0.734 |
IRAK1 |
0.761 | -0.224 | -1 | 0.757 |
PKG1 |
0.761 | 0.056 | -2 | 0.613 |
ROCK1 |
0.760 | 0.071 | -3 | 0.762 |
BIKE |
0.760 | 0.068 | 1 | 0.601 |
SLK |
0.760 | -0.053 | -2 | 0.688 |
CK1D |
0.759 | -0.037 | -3 | 0.490 |
TAK1 |
0.758 | -0.144 | 1 | 0.602 |
PDHK3_TYR |
0.758 | 0.154 | 4 | 0.820 |
NEK3 |
0.756 | -0.094 | 1 | 0.562 |
AAK1 |
0.755 | 0.111 | 1 | 0.550 |
YSK1 |
0.755 | -0.114 | 2 | 0.739 |
LIMK2_TYR |
0.754 | 0.134 | -3 | 0.871 |
PDHK4_TYR |
0.753 | 0.140 | 2 | 0.808 |
TTK |
0.753 | -0.035 | -2 | 0.759 |
CK1A2 |
0.753 | -0.062 | -3 | 0.491 |
CK1G1 |
0.752 | -0.087 | -3 | 0.531 |
TESK1_TYR |
0.752 | 0.066 | 3 | 0.812 |
MEK2 |
0.752 | -0.215 | 2 | 0.741 |
OSR1 |
0.749 | -0.070 | 2 | 0.750 |
MYO3B |
0.749 | -0.046 | 2 | 0.759 |
STK33 |
0.749 | -0.164 | 2 | 0.541 |
TTBK1 |
0.748 | -0.226 | 2 | 0.523 |
HASPIN |
0.747 | -0.023 | -1 | 0.692 |
MAP2K4_TYR |
0.746 | -0.049 | -1 | 0.836 |
GRK3 |
0.746 | -0.144 | -2 | 0.621 |
PKMYT1_TYR |
0.746 | -0.017 | 3 | 0.785 |
PLK2 |
0.745 | -0.104 | -3 | 0.771 |
MAP2K6_TYR |
0.745 | -0.030 | -1 | 0.833 |
RET |
0.745 | 0.005 | 1 | 0.602 |
TNK2 |
0.744 | 0.060 | 3 | 0.735 |
MAP2K7_TYR |
0.744 | -0.129 | 2 | 0.776 |
RIPK2 |
0.744 | -0.264 | 1 | 0.518 |
ASK1 |
0.743 | -0.140 | 1 | 0.549 |
CK2A2 |
0.741 | -0.114 | 1 | 0.485 |
TYRO3 |
0.741 | -0.027 | 3 | 0.752 |
ROS1 |
0.740 | -0.037 | 3 | 0.723 |
TAO1 |
0.740 | -0.116 | 1 | 0.525 |
MST1R |
0.739 | -0.061 | 3 | 0.772 |
PDHK1_TYR |
0.739 | -0.090 | -1 | 0.835 |
ABL2 |
0.739 | 0.009 | -1 | 0.779 |
MYO3A |
0.739 | -0.108 | 1 | 0.565 |
EPHB4 |
0.738 | -0.025 | -1 | 0.779 |
LIMK1_TYR |
0.738 | -0.082 | 2 | 0.779 |
PINK1_TYR |
0.738 | -0.189 | 1 | 0.631 |
TNK1 |
0.737 | 0.014 | 3 | 0.731 |
NEK10_TYR |
0.737 | 0.005 | 1 | 0.519 |
TYK2 |
0.737 | -0.109 | 1 | 0.595 |
BMPR2_TYR |
0.736 | -0.096 | -1 | 0.796 |
JAK2 |
0.736 | -0.074 | 1 | 0.602 |
CSF1R |
0.736 | -0.070 | 3 | 0.748 |
YES1 |
0.734 | -0.044 | -1 | 0.830 |
TXK |
0.734 | -0.002 | 1 | 0.582 |
ABL1 |
0.734 | -0.021 | -1 | 0.777 |
EPHA6 |
0.733 | -0.090 | -1 | 0.777 |
YANK3 |
0.733 | -0.084 | 2 | 0.335 |
CK2A1 |
0.732 | -0.119 | 1 | 0.466 |
DDR1 |
0.732 | -0.136 | 4 | 0.739 |
STLK3 |
0.732 | -0.142 | 1 | 0.523 |
FGR |
0.731 | -0.086 | 1 | 0.622 |
JAK3 |
0.730 | -0.096 | 1 | 0.588 |
AXL |
0.730 | -0.053 | 3 | 0.750 |
LCK |
0.730 | -0.022 | -1 | 0.788 |
JAK1 |
0.729 | -0.037 | 1 | 0.553 |
TNNI3K_TYR |
0.729 | -0.030 | 1 | 0.594 |
TEK |
0.729 | -0.037 | 3 | 0.696 |
PDGFRB |
0.728 | -0.115 | 3 | 0.756 |
FER |
0.728 | -0.135 | 1 | 0.638 |
FGFR1 |
0.727 | -0.068 | 3 | 0.730 |
ITK |
0.727 | -0.067 | -1 | 0.783 |
BLK |
0.727 | -0.023 | -1 | 0.787 |
INSRR |
0.726 | -0.121 | 3 | 0.697 |
ALPHAK3 |
0.726 | -0.157 | -1 | 0.706 |
MERTK |
0.726 | -0.071 | 3 | 0.745 |
FGFR2 |
0.726 | -0.114 | 3 | 0.745 |
KDR |
0.725 | -0.086 | 3 | 0.714 |
HCK |
0.725 | -0.112 | -1 | 0.795 |
EPHB3 |
0.725 | -0.089 | -1 | 0.766 |
EPHB1 |
0.724 | -0.104 | 1 | 0.598 |
SRMS |
0.724 | -0.117 | 1 | 0.597 |
PDGFRA |
0.722 | -0.141 | 3 | 0.748 |
KIT |
0.722 | -0.138 | 3 | 0.752 |
FLT3 |
0.722 | -0.147 | 3 | 0.746 |
EPHB2 |
0.722 | -0.098 | -1 | 0.756 |
DDR2 |
0.721 | -0.027 | 3 | 0.688 |
TEC |
0.721 | -0.077 | -1 | 0.731 |
EPHA4 |
0.721 | -0.122 | 2 | 0.666 |
BMX |
0.721 | -0.064 | -1 | 0.691 |
MET |
0.719 | -0.115 | 3 | 0.758 |
EPHA1 |
0.718 | -0.098 | 3 | 0.753 |
ALK |
0.717 | -0.138 | 3 | 0.670 |
LTK |
0.717 | -0.130 | 3 | 0.695 |
BTK |
0.715 | -0.176 | -1 | 0.782 |
CK1A |
0.715 | -0.084 | -3 | 0.405 |
FGFR3 |
0.714 | -0.139 | 3 | 0.721 |
FYN |
0.713 | -0.083 | -1 | 0.755 |
PTK2B |
0.713 | -0.093 | -1 | 0.756 |
LYN |
0.712 | -0.107 | 3 | 0.667 |
EPHA3 |
0.712 | -0.145 | 2 | 0.643 |
EPHA7 |
0.711 | -0.135 | 2 | 0.667 |
WEE1_TYR |
0.711 | -0.148 | -1 | 0.731 |
NTRK1 |
0.711 | -0.220 | -1 | 0.774 |
FRK |
0.710 | -0.147 | -1 | 0.805 |
PTK6 |
0.710 | -0.195 | -1 | 0.724 |
INSR |
0.710 | -0.177 | 3 | 0.686 |
NTRK2 |
0.710 | -0.206 | 3 | 0.708 |
ERBB2 |
0.709 | -0.191 | 1 | 0.548 |
FLT4 |
0.708 | -0.188 | 3 | 0.700 |
EPHA5 |
0.708 | -0.116 | 2 | 0.654 |
NTRK3 |
0.706 | -0.171 | -1 | 0.723 |
FLT1 |
0.706 | -0.195 | -1 | 0.754 |
MATK |
0.704 | -0.146 | -1 | 0.698 |
SRC |
0.702 | -0.143 | -1 | 0.761 |
EPHA8 |
0.700 | -0.155 | -1 | 0.727 |
YANK2 |
0.699 | -0.119 | 2 | 0.357 |
CSK |
0.697 | -0.198 | 2 | 0.670 |
EGFR |
0.697 | -0.159 | 1 | 0.470 |
MUSK |
0.697 | -0.162 | 1 | 0.466 |
CK1G3 |
0.696 | -0.089 | -3 | 0.358 |
FGFR4 |
0.695 | -0.170 | -1 | 0.710 |
PTK2 |
0.691 | -0.124 | -1 | 0.683 |
EPHA2 |
0.690 | -0.165 | -1 | 0.690 |
SYK |
0.689 | -0.133 | -1 | 0.673 |
ERBB4 |
0.688 | -0.134 | 1 | 0.487 |
IGF1R |
0.688 | -0.214 | 3 | 0.625 |
ZAP70 |
0.679 | -0.086 | -1 | 0.599 |
FES |
0.677 | -0.194 | -1 | 0.666 |
CK1G2 |
0.671 | -0.113 | -3 | 0.450 |