Motif 374 (n=197)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S254 | ochoa | Snf2 related CREBBP activator protein | None |
| A0MZ66 | SHTN1 | S514 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A6NKT7 | RGPD3 | S1275 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NNA2 | SRRM3 | S339 | ochoa | Serine/arginine repetitive matrix protein 3 | May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}. |
| A8CG34 | POM121C | S274 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00178 | GTPBP1 | S24 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O00178 | GTPBP1 | S643 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O00291 | HIP1 | S319 | ochoa | Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) | Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}. |
| O00472 | ELL2 | S315 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
| O14715 | RGPD8 | S1274 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14828 | SCAMP3 | Y86 | ochoa|psp | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15164 | TRIM24 | S664 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15211 | RGL2 | S588 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15357 | INPPL1 | S157 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O15439 | ABCC4 | S665 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O43395 | PRPF3 | S174 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:20595234}. |
| O43566 | RGS14 | S51 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O60245 | PCDH7 | S999 | ochoa | Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) | None |
| O60346 | PHLPP1 | S323 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60664 | PLIN3 | S137 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60861 | GAS7 | S162 | ochoa | Growth arrest-specific protein 7 (GAS-7) | May play a role in promoting maturation and morphological differentiation of cerebellar neurons. |
| O75044 | SRGAP2 | S993 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75864 | PPP1R37 | S560 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O75995 | SASH3 | S37 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O76094 | SRP72 | S620 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O94804 | STK10 | S454 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94875 | SORBS2 | S298 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O94875 | SORBS2 | S1025 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95155 | UBE4B | S326 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95251 | KAT7 | S56 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95425 | SVIL | S237 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95639 | CPSF4 | S211 | ochoa | Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}. |
| O95684 | CEP43 | S215 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O95817 | BAG3 | S190 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P04049 | RAF1 | S243 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04049 | RAF1 | S295 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P06400 | RB1 | S794 | ochoa | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P08651 | NFIC | S304 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P08670 | VIM | S55 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P09874 | PARP1 | S372 | ochoa|psp | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0C7T5 | ATXN1L | S215 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P10636 | MAPT | S437 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11274 | BCR | S381 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P15923 | TCF3 | S351 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P15924 | DSP | S2616 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P17676 | CEBPB | S230 | ochoa | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P38398 | BRCA1 | S1496 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P46531 | NOTCH1 | S2523 | psp | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P48681 | NES | S1451 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49327 | FASN | S724 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S2250 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49848 | TAF6 | S633 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P51003 | PAPOLA | S628 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P53671 | LIMK2 | S297 | ochoa | LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:8537403}. |
| P54725 | RAD23A | S143 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P57682 | KLF3 | S80 | ochoa | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P61244 | MAX | S117 | ochoa | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
| P78347 | GTF2I | S830 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P80723 | BASP1 | S182 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P85037 | FOXK1 | S249 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q00341 | HDLBP | S1246 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00587 | CDC42EP1 | S152 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q03188 | CENPC | S176 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q08495 | DMTN | S28 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q08999 | RBL2 | S972 | ochoa | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q08999 | RBL2 | S981 | ochoa | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q08AD1 | CAMSAP2 | S973 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09472 | EP300 | S2325 | ochoa | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q09666 | AHNAK | S5762 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13177 | PAK2 | S42 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13424 | SNTA1 | S200 | ochoa | Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}. |
| Q13480 | GAB1 | S276 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13501 | SQSTM1 | S287 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13501 | SQSTM1 | S365 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13526 | PIN1 | S42 | ochoa | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13546 | RIPK1 | S330 | ochoa | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13586 | STIM1 | S620 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q14004 | CDK13 | Y362 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14004 | CDK13 | S1162 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14157 | UBAP2L | S476 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14669 | TRIP12 | S87 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14687 | GSE1 | S94 | ochoa | Genetic suppressor element 1 | None |
| Q14980 | NUMA1 | S1882 | ochoa|psp | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15003 | NCAPH | S27 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15004 | PCLAF | S39 | ochoa | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Q15036 | SNX17 | S335 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15424 | SAFB | S383 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15555 | MAPRE2 | S229 | ochoa | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250|UniProtKB:Q8R001, ECO:0000269|PubMed:22373814, ECO:0000269|PubMed:23844040, ECO:0000269|PubMed:26527684, ECO:0000269|PubMed:27030108}. |
| Q15772 | SPEG | S559 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15772 | SPEG | S2176 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16204 | CCDC6 | S361 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16512 | PKN1 | S572 | ochoa | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q2KHR3 | QSER1 | S508 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q4V328 | GRIPAP1 | S691 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q504U0 | C4orf46 | S29 | ochoa | Renal cancer differentiation gene 1 protein | None |
| Q562F6 | SGO2 | S1150 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5JTV8 | TOR1AIP1 | S263 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5R372 | RABGAP1L | S118 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5SNT2 | TMEM201 | S555 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
| Q5T200 | ZC3H13 | S380 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5VU43 | PDE4DIP | S736 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VZK9 | CARMIL1 | S1290 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q68CZ2 | TNS3 | S362 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68CZ2 | TNS3 | S952 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6JBY9 | RCSD1 | S126 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6P0Q8 | MAST2 | S1306 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6PJE2 | POMZP3 | S32 | ochoa | POM121 and ZP3 fusion protein (POM-ZP3) | None |
| Q6VN20 | RANBP10 | S375 | ochoa | Ran-binding protein 10 (RanBP10) | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q6XZF7 | DNMBP | S1429 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZNJ1 | NBEAL2 | T1311 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZRS2 | SRCAP | S273 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRV2 | FAM83H | S924 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q765P7 | MTSS2 | S579 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7L9B9 | EEPD1 | S112 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z3J3 | RGPD4 | S1275 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3K3 | POGZ | S720 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z6Z7 | HUWE1 | S2917 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86V48 | LUZP1 | S804 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86YD5 | LDLRAD3 | S309 | ochoa | Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3) | May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). {ECO:0000250, ECO:0000269|PubMed:26854353}.; FUNCTION: (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}. |
| Q8IWC1 | MAP7D3 | S499 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IWS0 | PHF6 | S203 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IYB3 | SRRM1 | S695 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZD0 | SAMD14 | S150 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8N3V7 | SYNPO | S590 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N3V7 | SYNPO | S838 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N5H7 | SH2D3C | S415 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8N5I9 | NOPCHAP1 | S20 | ochoa | NOP protein chaperone 1 | Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2. {ECO:0000269|PubMed:33367824}. |
| Q8NBZ0 | INO80E | S108 | ochoa | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q8NDF8 | TENT4B | S55 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8NEM0 | MCPH1 | S286 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NFG4 | FLCN | S72 | ochoa | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}. |
| Q8NHH9 | ATL2 | S34 | ochoa | Atlastin-2 (ATL-2) (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) | Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:22065636, PubMed:27619977, PubMed:34817557). Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). {ECO:0000250|UniProtKB:Q8WXF7, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:22065636, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:34817557}. |
| Q8NI08 | NCOA7 | S182 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TB45 | DEPTOR | S292 | ochoa | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8TDY2 | RB1CC1 | S652 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TEM1 | NUP210 | T1862 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
| Q8TER5 | ARHGEF40 | S996 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8WUA4 | GTF3C2 | S775 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUF5 | PPP1R13L | S357 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q92574 | TSC1 | S525 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92793 | CREBBP | S2361 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q93074 | MED12 | S562 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96EE3 | SEH1L | S189 | ochoa | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC (PubMed:15146057, PubMed:17363900). The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (PubMed:15146057, PubMed:17363900). {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| Q96HA1 | POM121 | S297 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96JH7 | VCPIP1 | Y767 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
| Q96JM3 | CHAMP1 | S183 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S482 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96RU2 | USP28 | S503 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q99569 | PKP4 | S87 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99666 | RGPD5 | S1274 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQ61 | TRIR | S49 | ochoa | Telomerase RNA component interacting RNase (EC 3.1.13.-) (Exoribonuclease TRIR) | Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to cleave all four unpaired RNA nucleotides from the 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335). {ECO:0000269|PubMed:28322335}. |
| Q9BQI5 | SGIP1 | S492 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BR76 | CORO1B | S423 | ochoa | Coronin-1B (Coronin-2) | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}. |
| Q9BX40 | LSM14B | Y114 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
| Q9BXK1 | KLF16 | S111 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9BZF3 | OSBPL6 | S45 | ochoa | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. |
| Q9BZF3 | OSBPL6 | S343 | ochoa | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. |
| Q9C0B5 | ZDHHC5 | S371 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9H1A4 | ANAPC1 | S333 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H211 | CDT1 | S390 | ochoa | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H3D4 | TP63 | S462 | ochoa | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q9H5V7 | IKZF5 | S308 | ochoa | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:31217188}. |
| Q9H792 | PEAK1 | S729 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9HAU0 | PLEKHA5 | Y556 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HAU0 | PLEKHA5 | S567 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HB20 | PLEKHA3 | S221 | ochoa | Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) | Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}. |
| Q9HCK8 | CHD8 | S2518 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HCM3 | KIAA1549 | S1923 | ochoa | UPF0606 protein KIAA1549 | May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}. |
| Q9HCU4 | CELSR2 | S2675 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NQS7 | INCENP | S311 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NRA8 | EIF4ENIF1 | S680 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRA8 | EIF4ENIF1 | S751 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NXR1 | NDE1 | S224 | ochoa | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
| Q9NYF8 | BCLAF1 | Y284 | ochoa|psp | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYV4 | CDK12 | S1082 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZ52 | GGA3 | S381 | ochoa | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
| Q9NZJ0 | DTL | S495 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9NZN8 | CNOT2 | S169 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
| Q9P206 | NHSL3 | S351 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P206 | NHSL3 | S868 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P2N6 | KANSL3 | S535 | ochoa | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q9UBW5 | BIN2 | S435 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UDT6 | CLIP2 | S52 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UDY2 | TJP2 | S440 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UGP4 | LIMD1 | S352 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UGP4 | LIMD1 | S423 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UIW0 | VAX2 | S52 | ochoa | Ventral anterior homeobox 2 | Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. {ECO:0000250}. |
| Q9UK58 | CCNL1 | S341 | ochoa | Cyclin-L1 (Cyclin-L) | Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}. |
| Q9UKV3 | ACIN1 | S675 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULT8 | HECTD1 | S1529 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UPN3 | MACF1 | S7250 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPQ0 | LIMCH1 | S680 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ35 | SRRM2 | S332 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S913 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S934 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQR0 | SCML2 | S593 | ochoa | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y3S1 | WNK2 | S1817 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000003 | 5.547 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000003 | 5.486 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000003 | 5.547 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000009 | 5.052 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000010 | 4.985 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000010 | 4.985 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000014 | 4.857 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000014 | 4.857 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000016 | 4.796 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.000015 | 4.831 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000016 | 4.796 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000009 | 5.040 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000012 | 4.920 |
| R-HSA-75153 | Apoptotic execution phase | 0.000008 | 5.097 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.000018 | 4.736 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.000021 | 4.678 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000027 | 4.571 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.000027 | 4.566 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000031 | 4.512 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000039 | 4.408 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.000039 | 4.408 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.000041 | 4.384 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.000044 | 4.358 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.000079 | 4.101 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.000075 | 4.123 |
| R-HSA-68886 | M Phase | 0.000083 | 4.083 |
| R-HSA-1640170 | Cell Cycle | 0.000081 | 4.092 |
| R-HSA-68875 | Mitotic Prophase | 0.000073 | 4.136 |
| R-HSA-3371556 | Cellular response to heat stress | 0.000077 | 4.112 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.000083 | 4.079 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.000102 | 3.991 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.000118 | 3.927 |
| R-HSA-109581 | Apoptosis | 0.000138 | 3.861 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.000183 | 3.738 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000183 | 3.738 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.000237 | 3.625 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000237 | 3.625 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000226 | 3.646 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.000265 | 3.577 |
| R-HSA-191859 | snRNP Assembly | 0.000265 | 3.577 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.000310 | 3.509 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.000546 | 3.263 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.000585 | 3.233 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.000670 | 3.174 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.000675 | 3.171 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.000669 | 3.174 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.000743 | 3.129 |
| R-HSA-5357801 | Programmed Cell Death | 0.000780 | 3.108 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.000877 | 3.057 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.001189 | 2.925 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.001246 | 2.905 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.001265 | 2.898 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.001519 | 2.818 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.001519 | 2.818 |
| R-HSA-68877 | Mitotic Prometaphase | 0.001929 | 2.715 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.001955 | 2.709 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.002302 | 2.638 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.002343 | 2.630 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.002840 | 2.547 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.002840 | 2.547 |
| R-HSA-70171 | Glycolysis | 0.003444 | 2.463 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.003463 | 2.461 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.003833 | 2.416 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.003833 | 2.416 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.003972 | 2.401 |
| R-HSA-168255 | Influenza Infection | 0.004552 | 2.342 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.004625 | 2.335 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.005203 | 2.284 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.005126 | 2.290 |
| R-HSA-74160 | Gene expression (Transcription) | 0.005219 | 2.282 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.004864 | 2.313 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.005126 | 2.290 |
| R-HSA-211000 | Gene Silencing by RNA | 0.004808 | 2.318 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.005239 | 2.281 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.005498 | 2.260 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.006831 | 2.166 |
| R-HSA-70326 | Glucose metabolism | 0.007545 | 2.122 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.007627 | 2.118 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.007712 | 2.113 |
| R-HSA-9839394 | TGFBR3 expression | 0.007866 | 2.104 |
| R-HSA-8875656 | MET receptor recycling | 0.009151 | 2.039 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.008667 | 2.062 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.008667 | 2.062 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.009151 | 2.039 |
| R-HSA-162587 | HIV Life Cycle | 0.008182 | 2.087 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.009996 | 2.000 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.010128 | 1.994 |
| R-HSA-69206 | G1/S Transition | 0.010232 | 1.990 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.010784 | 1.967 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.010799 | 1.967 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.010799 | 1.967 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.010799 | 1.967 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 0.012834 | 1.892 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.012813 | 1.892 |
| R-HSA-68882 | Mitotic Anaphase | 0.012320 | 1.909 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.012608 | 1.899 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.011757 | 1.930 |
| R-HSA-162582 | Signal Transduction | 0.012141 | 1.916 |
| R-HSA-72306 | tRNA processing | 0.012087 | 1.918 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.013227 | 1.879 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.013439 | 1.872 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.014453 | 1.840 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.014535 | 1.838 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.015537 | 1.809 |
| R-HSA-162906 | HIV Infection | 0.015766 | 1.802 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.016453 | 1.784 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.016453 | 1.784 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.018563 | 1.731 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.020781 | 1.682 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.020563 | 1.687 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.020597 | 1.686 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.020781 | 1.682 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.020781 | 1.682 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.020781 | 1.682 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.018770 | 1.727 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.019152 | 1.718 |
| R-HSA-69242 | S Phase | 0.021696 | 1.664 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.022348 | 1.651 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.022494 | 1.648 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.023974 | 1.620 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.025504 | 1.593 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.025504 | 1.593 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.025504 | 1.593 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.025504 | 1.593 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.025528 | 1.593 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.025528 | 1.593 |
| R-HSA-9610379 | HCMV Late Events | 0.027133 | 1.567 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.028050 | 1.552 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.030668 | 1.513 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.028050 | 1.552 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.030668 | 1.513 |
| R-HSA-6806834 | Signaling by MET | 0.028136 | 1.551 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.030668 | 1.513 |
| R-HSA-2262752 | Cellular responses to stress | 0.028664 | 1.543 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.029129 | 1.536 |
| R-HSA-5688426 | Deubiquitination | 0.027605 | 1.559 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.033574 | 1.474 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.032892 | 1.483 |
| R-HSA-5619102 | SLC transporter disorders | 0.034156 | 1.467 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.036180 | 1.442 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.036180 | 1.442 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.036180 | 1.442 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.038013 | 1.420 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 0.038013 | 1.420 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.038410 | 1.416 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.039068 | 1.408 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.042041 | 1.376 |
| R-HSA-9843745 | Adipogenesis | 0.043201 | 1.365 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.043505 | 1.361 |
| R-HSA-72187 | mRNA 3'-end processing | 0.043581 | 1.361 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.045096 | 1.346 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.050361 | 1.298 |
| R-HSA-8865999 | MET activates PTPN11 | 0.062552 | 1.204 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.054902 | 1.260 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.058958 | 1.229 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.058958 | 1.229 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.058958 | 1.229 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.058958 | 1.229 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.058958 | 1.229 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.062552 | 1.204 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.051441 | 1.289 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.058083 | 1.236 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.061038 | 1.214 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.052559 | 1.279 |
| R-HSA-1632852 | Macroautophagy | 0.055508 | 1.256 |
| R-HSA-3214847 | HATs acetylate histones | 0.055480 | 1.256 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.048341 | 1.316 |
| R-HSA-9609690 | HCMV Early Events | 0.061853 | 1.209 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.053841 | 1.269 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.055480 | 1.256 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.052926 | 1.276 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.054902 | 1.260 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.048230 | 1.317 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.049080 | 1.309 |
| R-HSA-186712 | Regulation of beta-cell development | 0.056912 | 1.245 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.051802 | 1.286 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.063151 | 1.200 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.065004 | 1.187 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.065004 | 1.187 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.065004 | 1.187 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.065004 | 1.187 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.065298 | 1.185 |
| R-HSA-9758941 | Gastrulation | 0.066936 | 1.174 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.068282 | 1.166 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.068563 | 1.164 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.069693 | 1.157 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.069693 | 1.157 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.071939 | 1.143 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.073811 | 1.132 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.074587 | 1.127 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.074587 | 1.127 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 0.074587 | 1.127 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.074587 | 1.127 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.074587 | 1.127 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.074587 | 1.127 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.075868 | 1.120 |
| R-HSA-9612973 | Autophagy | 0.076666 | 1.115 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.077687 | 1.110 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.079609 | 1.099 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.079609 | 1.099 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.079609 | 1.099 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.086469 | 1.063 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.098198 | 1.008 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.098198 | 1.008 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.096108 | 1.017 |
| R-HSA-1538133 | G0 and Early G1 | 0.087258 | 1.059 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.117495 | 0.930 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.109212 | 0.962 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.109212 | 0.962 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.109212 | 0.962 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.111990 | 0.951 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.087258 | 1.059 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.119796 | 0.922 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.095116 | 1.022 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.107263 | 0.970 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.107263 | 0.970 |
| R-HSA-8875878 | MET promotes cell motility | 0.115578 | 0.937 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.091162 | 1.040 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.088542 | 1.053 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.081750 | 1.088 |
| R-HSA-114608 | Platelet degranulation | 0.113413 | 0.945 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.098198 | 1.008 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.111400 | 0.953 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.111400 | 0.953 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.111400 | 0.953 |
| R-HSA-8964011 | HDL clearance | 0.109778 | 0.959 |
| R-HSA-164944 | Nef and signal transduction | 0.109778 | 0.959 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.081241 | 1.090 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.083406 | 1.079 |
| R-HSA-212436 | Generic Transcription Pathway | 0.115318 | 0.938 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.103046 | 0.987 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.086078 | 1.065 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.103928 | 0.983 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.091035 | 1.041 |
| R-HSA-913531 | Interferon Signaling | 0.080677 | 1.093 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.120284 | 0.920 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.121209 | 0.916 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.121209 | 0.916 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.121209 | 0.916 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.121209 | 0.916 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.121209 | 0.916 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.121209 | 0.916 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.121209 | 0.916 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.121209 | 0.916 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.124052 | 0.906 |
| R-HSA-3371568 | Attenuation phase | 0.124052 | 0.906 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.125936 | 0.900 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.128343 | 0.892 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.128343 | 0.892 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.132495 | 0.878 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.132495 | 0.878 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.132495 | 0.878 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.132495 | 0.878 |
| R-HSA-9613354 | Lipophagy | 0.143636 | 0.843 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.143636 | 0.843 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.143636 | 0.843 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.154635 | 0.811 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.154635 | 0.811 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.165493 | 0.781 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.176213 | 0.754 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.176213 | 0.754 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.176213 | 0.754 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.186795 | 0.729 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.186795 | 0.729 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.197242 | 0.705 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.197242 | 0.705 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.217738 | 0.662 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.227789 | 0.642 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.227789 | 0.642 |
| R-HSA-180292 | GAB1 signalosome | 0.257179 | 0.590 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.186730 | 0.729 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.131682 | 0.880 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.233711 | 0.631 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.233711 | 0.631 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.247965 | 0.606 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.176213 | 0.754 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.237712 | 0.624 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.186795 | 0.729 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.237712 | 0.624 |
| R-HSA-4641265 | Repression of WNT target genes | 0.186795 | 0.729 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.176213 | 0.754 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.247508 | 0.606 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.186795 | 0.729 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.132495 | 0.878 |
| R-HSA-176974 | Unwinding of DNA | 0.143636 | 0.843 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.154635 | 0.811 |
| R-HSA-192814 | vRNA Synthesis | 0.165493 | 0.781 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.176213 | 0.754 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.176213 | 0.754 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.197242 | 0.705 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.217738 | 0.662 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.237712 | 0.624 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.257179 | 0.590 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.206686 | 0.685 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.217738 | 0.662 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.186795 | 0.729 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.193537 | 0.713 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.132495 | 0.878 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.247508 | 0.606 |
| R-HSA-9824272 | Somitogenesis | 0.150287 | 0.823 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.186730 | 0.729 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.145839 | 0.836 |
| R-HSA-69236 | G1 Phase | 0.145839 | 0.836 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.247508 | 0.606 |
| R-HSA-9711097 | Cellular response to starvation | 0.194450 | 0.711 |
| R-HSA-157118 | Signaling by NOTCH | 0.247142 | 0.607 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.197242 | 0.705 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.132495 | 0.878 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.165493 | 0.781 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.237712 | 0.624 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.257179 | 0.590 |
| R-HSA-9664873 | Pexophagy | 0.154635 | 0.811 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.149448 | 0.826 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.154763 | 0.810 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.207556 | 0.683 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.207556 | 0.683 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.128666 | 0.891 |
| R-HSA-3928664 | Ephrin signaling | 0.257179 | 0.590 |
| R-HSA-428540 | Activation of RAC1 | 0.176213 | 0.754 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.182104 | 0.740 |
| R-HSA-9663891 | Selective autophagy | 0.131682 | 0.880 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.143636 | 0.843 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.186795 | 0.729 |
| R-HSA-69239 | Synthesis of DNA | 0.200085 | 0.699 |
| R-HSA-8851805 | MET activates RAS signaling | 0.186795 | 0.729 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.207556 | 0.683 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.207556 | 0.683 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.257179 | 0.590 |
| R-HSA-2559583 | Cellular Senescence | 0.257001 | 0.590 |
| R-HSA-8953854 | Metabolism of RNA | 0.218957 | 0.660 |
| R-HSA-5689877 | Josephin domain DUBs | 0.154635 | 0.811 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.197242 | 0.705 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.247508 | 0.606 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.247508 | 0.606 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.154635 | 0.811 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.217738 | 0.662 |
| R-HSA-8854214 | TBC/RABGAPs | 0.141419 | 0.849 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.257179 | 0.590 |
| R-HSA-9609646 | HCMV Infection | 0.139056 | 0.857 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.177496 | 0.751 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.203379 | 0.692 |
| R-HSA-9707616 | Heme signaling | 0.228970 | 0.640 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.227789 | 0.642 |
| R-HSA-73893 | DNA Damage Bypass | 0.168337 | 0.774 |
| R-HSA-9833110 | RSV-host interactions | 0.190283 | 0.721 |
| R-HSA-1266738 | Developmental Biology | 0.252299 | 0.598 |
| R-HSA-9842663 | Signaling by LTK | 0.186795 | 0.729 |
| R-HSA-2028269 | Signaling by Hippo | 0.247508 | 0.606 |
| R-HSA-373755 | Semaphorin interactions | 0.233711 | 0.631 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.217738 | 0.662 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.200702 | 0.697 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.231989 | 0.635 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.197242 | 0.705 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.247508 | 0.606 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.199694 | 0.700 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.207556 | 0.683 |
| R-HSA-1483255 | PI Metabolism | 0.180610 | 0.743 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.243210 | 0.614 |
| R-HSA-9679506 | SARS-CoV Infections | 0.128731 | 0.890 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.145839 | 0.836 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.134011 | 0.873 |
| R-HSA-5218859 | Regulated Necrosis | 0.257485 | 0.589 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.265460 | 0.576 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.266726 | 0.574 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.266726 | 0.574 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.266726 | 0.574 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.266726 | 0.574 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.266726 | 0.574 |
| R-HSA-392517 | Rap1 signalling | 0.266726 | 0.574 |
| R-HSA-9834899 | Specification of the neural plate border | 0.266726 | 0.574 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.266726 | 0.574 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.267011 | 0.573 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.271775 | 0.566 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.271775 | 0.566 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.271775 | 0.566 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.276151 | 0.559 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.276151 | 0.559 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.276151 | 0.559 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.276151 | 0.559 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.276151 | 0.559 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.276151 | 0.559 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.281297 | 0.551 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.281297 | 0.551 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.285455 | 0.544 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.285455 | 0.544 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.285455 | 0.544 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.285455 | 0.544 |
| R-HSA-380287 | Centrosome maturation | 0.290810 | 0.536 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.290810 | 0.536 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.294640 | 0.531 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.294640 | 0.531 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.294640 | 0.531 |
| R-HSA-5689603 | UCH proteinases | 0.295561 | 0.529 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.295561 | 0.529 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.296874 | 0.527 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.303604 | 0.518 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.303708 | 0.518 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.303708 | 0.518 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.303708 | 0.518 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.303708 | 0.518 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.303708 | 0.518 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.312660 | 0.505 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.312660 | 0.505 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.312660 | 0.505 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.314514 | 0.502 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.320383 | 0.494 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.321497 | 0.493 |
| R-HSA-429947 | Deadenylation of mRNA | 0.321497 | 0.493 |
| R-HSA-72172 | mRNA Splicing | 0.328723 | 0.483 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.330221 | 0.481 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.330221 | 0.481 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.330221 | 0.481 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.330221 | 0.481 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.331311 | 0.480 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.333353 | 0.477 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.338834 | 0.470 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.338834 | 0.470 |
| R-HSA-3295583 | TRP channels | 0.338834 | 0.470 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.338834 | 0.470 |
| R-HSA-525793 | Myogenesis | 0.338834 | 0.470 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.338834 | 0.470 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.344967 | 0.462 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.347336 | 0.459 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.347336 | 0.459 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.347336 | 0.459 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.347386 | 0.459 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.351618 | 0.454 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.352043 | 0.453 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.355730 | 0.449 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.355730 | 0.449 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.355730 | 0.449 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.355730 | 0.449 |
| R-HSA-5620971 | Pyroptosis | 0.355730 | 0.449 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.364016 | 0.439 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.364016 | 0.439 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.364016 | 0.439 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.364016 | 0.439 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.364016 | 0.439 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.364016 | 0.439 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.365942 | 0.437 |
| R-HSA-73894 | DNA Repair | 0.367770 | 0.434 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.370550 | 0.431 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.372196 | 0.429 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.372196 | 0.429 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.372196 | 0.429 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.372196 | 0.429 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.372196 | 0.429 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.374646 | 0.426 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.379726 | 0.421 |
| R-HSA-69306 | DNA Replication | 0.379937 | 0.420 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.380271 | 0.420 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.380271 | 0.420 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.380271 | 0.420 |
| R-HSA-73887 | Death Receptor Signaling | 0.383415 | 0.416 |
| R-HSA-1989781 | PPARA activates gene expression | 0.386890 | 0.412 |
| R-HSA-69190 | DNA strand elongation | 0.388243 | 0.411 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.388243 | 0.411 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.393824 | 0.405 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.396113 | 0.402 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.396113 | 0.402 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.396113 | 0.402 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.396113 | 0.402 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.396113 | 0.402 |
| R-HSA-9930044 | Nuclear RNA decay | 0.396113 | 0.402 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.396113 | 0.402 |
| R-HSA-390522 | Striated Muscle Contraction | 0.403882 | 0.394 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.403882 | 0.394 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.403882 | 0.394 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.403882 | 0.394 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.403882 | 0.394 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.406906 | 0.391 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.411552 | 0.386 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.411552 | 0.386 |
| R-HSA-5673000 | RAF activation | 0.411552 | 0.386 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.411552 | 0.386 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.411552 | 0.386 |
| R-HSA-5205647 | Mitophagy | 0.411552 | 0.386 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.411552 | 0.386 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.411552 | 0.386 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.411552 | 0.386 |
| R-HSA-9824446 | Viral Infection Pathways | 0.413644 | 0.383 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.415840 | 0.381 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.415926 | 0.381 |
| R-HSA-169911 | Regulation of Apoptosis | 0.419123 | 0.378 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.419123 | 0.378 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.419123 | 0.378 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.419123 | 0.378 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.419123 | 0.378 |
| R-HSA-381042 | PERK regulates gene expression | 0.419123 | 0.378 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.419123 | 0.378 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.419123 | 0.378 |
| R-HSA-6798695 | Neutrophil degranulation | 0.422075 | 0.375 |
| R-HSA-8853659 | RET signaling | 0.426597 | 0.370 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.426597 | 0.370 |
| R-HSA-163560 | Triglyceride catabolism | 0.426597 | 0.370 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.433976 | 0.363 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.433976 | 0.363 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.437874 | 0.359 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.437874 | 0.359 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.441260 | 0.355 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.441260 | 0.355 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.442227 | 0.354 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.442227 | 0.354 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.445320 | 0.351 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.446561 | 0.350 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.448444 | 0.348 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.448451 | 0.348 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.448451 | 0.348 |
| R-HSA-201556 | Signaling by ALK | 0.448451 | 0.348 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.450877 | 0.346 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.455536 | 0.341 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.455550 | 0.341 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.455550 | 0.341 |
| R-HSA-5260271 | Diseases of Immune System | 0.455550 | 0.341 |
| R-HSA-9646399 | Aggrephagy | 0.455550 | 0.341 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.455550 | 0.341 |
| R-HSA-202433 | Generation of second messenger molecules | 0.455550 | 0.341 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.455550 | 0.341 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.458476 | 0.339 |
| R-HSA-4839726 | Chromatin organization | 0.458748 | 0.338 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.462558 | 0.335 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.462558 | 0.335 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.462558 | 0.335 |
| R-HSA-9694548 | Maturation of spike protein | 0.462558 | 0.335 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.462558 | 0.335 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.467948 | 0.330 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.467948 | 0.330 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.469476 | 0.328 |
| R-HSA-167161 | HIV Transcription Initiation | 0.469476 | 0.328 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.469476 | 0.328 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.469476 | 0.328 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.469476 | 0.328 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.469476 | 0.328 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.476306 | 0.322 |
| R-HSA-165159 | MTOR signalling | 0.476306 | 0.322 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.476306 | 0.322 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.478380 | 0.320 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.483048 | 0.316 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.483048 | 0.316 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.489703 | 0.310 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.492956 | 0.307 |
| R-HSA-69275 | G2/M Transition | 0.494571 | 0.306 |
| R-HSA-774815 | Nucleosome assembly | 0.496274 | 0.304 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.496274 | 0.304 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.496274 | 0.304 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.496274 | 0.304 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.501008 | 0.300 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.502760 | 0.299 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.502760 | 0.299 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.502760 | 0.299 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.502760 | 0.299 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.502760 | 0.299 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.502760 | 0.299 |
| R-HSA-9675135 | Diseases of DNA repair | 0.502760 | 0.299 |
| R-HSA-983712 | Ion channel transport | 0.504210 | 0.297 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.505180 | 0.297 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.509163 | 0.293 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.509163 | 0.293 |
| R-HSA-437239 | Recycling pathway of L1 | 0.509163 | 0.293 |
| R-HSA-5693538 | Homology Directed Repair | 0.509212 | 0.293 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.515484 | 0.288 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.515484 | 0.288 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.515484 | 0.288 |
| R-HSA-109704 | PI3K Cascade | 0.527884 | 0.277 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.527884 | 0.277 |
| R-HSA-9748787 | Azathioprine ADME | 0.527884 | 0.277 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.532953 | 0.273 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.533965 | 0.272 |
| R-HSA-912446 | Meiotic recombination | 0.533965 | 0.272 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.538723 | 0.269 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.539968 | 0.268 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.539968 | 0.268 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.539968 | 0.268 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.545894 | 0.263 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.545894 | 0.263 |
| R-HSA-1221632 | Meiotic synapsis | 0.545894 | 0.263 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.545894 | 0.263 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.547897 | 0.261 |
| R-HSA-69481 | G2/M Checkpoints | 0.548342 | 0.261 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.551744 | 0.258 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.557519 | 0.254 |
| R-HSA-9753281 | Paracetamol ADME | 0.557519 | 0.254 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.559649 | 0.252 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.563220 | 0.249 |
| R-HSA-75893 | TNF signaling | 0.563220 | 0.249 |
| R-HSA-177929 | Signaling by EGFR | 0.563220 | 0.249 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.563220 | 0.249 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.563220 | 0.249 |
| R-HSA-5578775 | Ion homeostasis | 0.563220 | 0.249 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.563220 | 0.249 |
| R-HSA-112399 | IRS-mediated signalling | 0.568848 | 0.245 |
| R-HSA-9909396 | Circadian clock | 0.570754 | 0.244 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.574404 | 0.241 |
| R-HSA-397014 | Muscle contraction | 0.577695 | 0.238 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.579888 | 0.237 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.579888 | 0.237 |
| R-HSA-8979227 | Triglyceride metabolism | 0.579888 | 0.237 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.580557 | 0.236 |
| R-HSA-1483257 | Phospholipid metabolism | 0.581884 | 0.235 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.585302 | 0.233 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.585302 | 0.233 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.588811 | 0.230 |
| R-HSA-163685 | Integration of energy metabolism | 0.588811 | 0.230 |
| R-HSA-195721 | Signaling by WNT | 0.589356 | 0.230 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.590647 | 0.229 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.595923 | 0.225 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.595923 | 0.225 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.599553 | 0.222 |
| R-HSA-8951664 | Neddylation | 0.603445 | 0.219 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.606273 | 0.217 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.606273 | 0.217 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.611349 | 0.214 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.617298 | 0.210 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.621306 | 0.207 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.621306 | 0.207 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.626189 | 0.203 |
| R-HSA-167172 | Transcription of the HIV genome | 0.626189 | 0.203 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.633108 | 0.199 |
| R-HSA-166520 | Signaling by NTRKs | 0.633108 | 0.199 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.635767 | 0.197 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.635767 | 0.197 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.640464 | 0.194 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.640464 | 0.194 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.645101 | 0.190 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.649130 | 0.188 |
| R-HSA-4086398 | Ca2+ pathway | 0.649679 | 0.187 |
| R-HSA-8957322 | Metabolism of steroids | 0.650744 | 0.187 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.654198 | 0.184 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.654198 | 0.184 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.658658 | 0.181 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.667408 | 0.176 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.671699 | 0.173 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.680117 | 0.167 |
| R-HSA-9833482 | PKR-mediated signaling | 0.680117 | 0.167 |
| R-HSA-597592 | Post-translational protein modification | 0.682995 | 0.166 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.684245 | 0.165 |
| R-HSA-977225 | Amyloid fiber formation | 0.684245 | 0.165 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.684245 | 0.165 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.692342 | 0.160 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.696313 | 0.157 |
| R-HSA-1500620 | Meiosis | 0.700233 | 0.155 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.700233 | 0.155 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.700233 | 0.155 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.710423 | 0.148 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.710423 | 0.148 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.710423 | 0.148 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.711693 | 0.148 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.714312 | 0.146 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.715415 | 0.145 |
| R-HSA-73884 | Base Excision Repair | 0.722717 | 0.141 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.733321 | 0.135 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.733321 | 0.135 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.733321 | 0.135 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.736765 | 0.133 |
| R-HSA-168256 | Immune System | 0.740017 | 0.131 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.740165 | 0.131 |
| R-HSA-422475 | Axon guidance | 0.742038 | 0.130 |
| R-HSA-5617833 | Cilium Assembly | 0.753283 | 0.123 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.755626 | 0.122 |
| R-HSA-190236 | Signaling by FGFR | 0.756521 | 0.121 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.757951 | 0.120 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.759667 | 0.119 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.762772 | 0.118 |
| R-HSA-168249 | Innate Immune System | 0.763911 | 0.117 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.765838 | 0.116 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.767058 | 0.115 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.768864 | 0.114 |
| R-HSA-418346 | Platelet homeostasis | 0.783421 | 0.106 |
| R-HSA-1643685 | Disease | 0.783842 | 0.106 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.786221 | 0.104 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.788985 | 0.103 |
| R-HSA-6805567 | Keratinization | 0.790588 | 0.102 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.791713 | 0.101 |
| R-HSA-9675108 | Nervous system development | 0.793902 | 0.100 |
| R-HSA-202403 | TCR signaling | 0.794407 | 0.100 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.794407 | 0.100 |
| R-HSA-6803157 | Antimicrobial peptides | 0.797065 | 0.099 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.799690 | 0.097 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.802280 | 0.096 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.804838 | 0.094 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.809854 | 0.092 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.812314 | 0.090 |
| R-HSA-418990 | Adherens junctions interactions | 0.813854 | 0.089 |
| R-HSA-373760 | L1CAM interactions | 0.814742 | 0.089 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.816909 | 0.088 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.817139 | 0.088 |
| R-HSA-1280218 | Adaptive Immune System | 0.818527 | 0.087 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.819505 | 0.086 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.821840 | 0.085 |
| R-HSA-73886 | Chromosome Maintenance | 0.826421 | 0.083 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.830885 | 0.080 |
| R-HSA-194138 | Signaling by VEGF | 0.837368 | 0.077 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.843603 | 0.074 |
| R-HSA-449147 | Signaling by Interleukins | 0.843761 | 0.074 |
| R-HSA-8939211 | ESR-mediated signaling | 0.846007 | 0.073 |
| R-HSA-1474165 | Reproduction | 0.849601 | 0.071 |
| R-HSA-5576891 | Cardiac conduction | 0.851548 | 0.070 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.854804 | 0.068 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.862719 | 0.064 |
| R-HSA-199991 | Membrane Trafficking | 0.866166 | 0.062 |
| R-HSA-421270 | Cell-cell junction organization | 0.866392 | 0.062 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.867987 | 0.061 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.887120 | 0.052 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.890029 | 0.051 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.898315 | 0.047 |
| R-HSA-446728 | Cell junction organization | 0.898896 | 0.046 |
| R-HSA-109582 | Hemostasis | 0.898979 | 0.046 |
| R-HSA-877300 | Interferon gamma signaling | 0.899635 | 0.046 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.909904 | 0.041 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.915427 | 0.038 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.916316 | 0.038 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.919628 | 0.036 |
| R-HSA-3781865 | Diseases of glycosylation | 0.928552 | 0.032 |
| R-HSA-1500931 | Cell-Cell communication | 0.932361 | 0.030 |
| R-HSA-5663205 | Infectious disease | 0.937154 | 0.028 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.942052 | 0.026 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.944284 | 0.025 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.944284 | 0.025 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.948915 | 0.023 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.951126 | 0.022 |
| R-HSA-9748784 | Drug ADME | 0.954822 | 0.020 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.959230 | 0.018 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.961401 | 0.017 |
| R-HSA-392499 | Metabolism of proteins | 0.976573 | 0.010 |
| R-HSA-112316 | Neuronal System | 0.987691 | 0.005 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.988648 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 0.988999 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 0.989786 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 0.990588 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.993397 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 0.996314 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 0.996314 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 0.997174 | 0.001 |
| R-HSA-72766 | Translation | 0.997248 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.999685 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999888 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.762 | 0.164 | 2 | 0.538 |
CLK3 |
0.762 | 0.144 | 1 | 0.200 |
CDC7 |
0.761 | 0.261 | 1 | 0.319 |
GRK1 |
0.759 | 0.218 | -2 | 0.847 |
BMPR1B |
0.755 | 0.326 | 1 | 0.452 |
KIS |
0.754 | 0.076 | 1 | 0.134 |
MOS |
0.752 | 0.199 | 1 | 0.247 |
NDR2 |
0.749 | 0.105 | -3 | 0.850 |
PIM3 |
0.747 | 0.103 | -3 | 0.830 |
CHAK2 |
0.746 | 0.127 | -1 | 0.692 |
GRK7 |
0.746 | 0.179 | 1 | 0.281 |
CDK1 |
0.744 | 0.051 | 1 | 0.190 |
IKKB |
0.743 | 0.022 | -2 | 0.763 |
HIPK4 |
0.742 | 0.091 | 1 | 0.159 |
PRKD1 |
0.741 | 0.098 | -3 | 0.803 |
MTOR |
0.740 | -0.014 | 1 | 0.185 |
GRK5 |
0.739 | 0.138 | -3 | 0.876 |
IKKA |
0.738 | 0.065 | -2 | 0.760 |
SKMLCK |
0.737 | 0.112 | -2 | 0.864 |
RSK2 |
0.737 | 0.086 | -3 | 0.736 |
HIPK2 |
0.737 | 0.042 | 1 | 0.130 |
GRK2 |
0.736 | 0.253 | -2 | 0.752 |
MAPKAPK2 |
0.735 | 0.073 | -3 | 0.709 |
SRPK1 |
0.734 | 0.038 | -3 | 0.720 |
TBK1 |
0.734 | -0.083 | 1 | 0.169 |
PRKD2 |
0.734 | 0.062 | -3 | 0.740 |
PRPK |
0.734 | -0.014 | -1 | 0.679 |
ATR |
0.733 | 0.004 | 1 | 0.197 |
GRK6 |
0.733 | 0.138 | 1 | 0.331 |
CDK18 |
0.733 | 0.013 | 1 | 0.137 |
LATS2 |
0.733 | 0.049 | -5 | 0.706 |
NLK |
0.732 | -0.015 | 1 | 0.201 |
IKKE |
0.732 | -0.080 | 1 | 0.170 |
MST4 |
0.732 | -0.005 | 2 | 0.586 |
AURC |
0.732 | 0.065 | -2 | 0.639 |
RAF1 |
0.731 | -0.015 | 1 | 0.230 |
ACVR2B |
0.731 | 0.237 | -2 | 0.797 |
NDR1 |
0.730 | 0.009 | -3 | 0.820 |
BMPR1A |
0.730 | 0.228 | 1 | 0.431 |
GCN2 |
0.730 | -0.124 | 2 | 0.517 |
TGFBR1 |
0.730 | 0.170 | -2 | 0.819 |
CDK19 |
0.730 | -0.009 | 1 | 0.144 |
RSK4 |
0.730 | 0.098 | -3 | 0.722 |
PIM1 |
0.730 | 0.048 | -3 | 0.767 |
CAMK2A |
0.729 | 0.084 | 2 | 0.510 |
CLK2 |
0.729 | 0.078 | -3 | 0.719 |
PKN2 |
0.729 | 0.001 | -3 | 0.816 |
TGFBR2 |
0.729 | 0.050 | -2 | 0.791 |
ERK5 |
0.729 | -0.028 | 1 | 0.181 |
MLK3 |
0.729 | 0.015 | 2 | 0.463 |
CDK3 |
0.729 | 0.025 | 1 | 0.147 |
CDK8 |
0.728 | -0.022 | 1 | 0.153 |
MLK1 |
0.728 | -0.045 | 2 | 0.504 |
GRK3 |
0.728 | 0.215 | -2 | 0.717 |
P90RSK |
0.728 | 0.055 | -3 | 0.737 |
CAMK2G |
0.728 | -0.041 | 2 | 0.512 |
CAMK1B |
0.727 | -0.003 | -3 | 0.827 |
JNK2 |
0.727 | 0.003 | 1 | 0.153 |
CDK17 |
0.727 | -0.001 | 1 | 0.144 |
DSTYK |
0.727 | -0.051 | 2 | 0.554 |
NEK6 |
0.727 | -0.045 | -2 | 0.852 |
ACVR2A |
0.727 | 0.214 | -2 | 0.781 |
CK1E |
0.727 | 0.123 | -3 | 0.670 |
BMPR2 |
0.727 | -0.022 | -2 | 0.885 |
DLK |
0.727 | 0.080 | 1 | 0.275 |
PASK |
0.726 | 0.224 | -3 | 0.860 |
ALK4 |
0.726 | 0.157 | -2 | 0.842 |
CAMK2B |
0.726 | 0.050 | 2 | 0.487 |
P38G |
0.726 | -0.008 | 1 | 0.147 |
LATS1 |
0.726 | 0.115 | -3 | 0.860 |
CDK7 |
0.726 | -0.000 | 1 | 0.152 |
DRAK1 |
0.725 | 0.229 | 1 | 0.454 |
CDK5 |
0.725 | 0.002 | 1 | 0.157 |
CAMK2D |
0.725 | -0.000 | -3 | 0.811 |
GRK4 |
0.725 | 0.024 | -2 | 0.861 |
ULK2 |
0.725 | -0.140 | 2 | 0.495 |
PKN3 |
0.724 | -0.036 | -3 | 0.801 |
MAPKAPK3 |
0.724 | 0.016 | -3 | 0.750 |
AMPKA1 |
0.724 | 0.014 | -3 | 0.836 |
PKACG |
0.724 | 0.005 | -2 | 0.738 |
JNK3 |
0.724 | -0.009 | 1 | 0.147 |
DYRK2 |
0.723 | -0.012 | 1 | 0.157 |
PDHK4 |
0.723 | -0.157 | 1 | 0.210 |
RIPK3 |
0.723 | -0.056 | 3 | 0.680 |
PKCD |
0.723 | -0.018 | 2 | 0.492 |
MLK2 |
0.723 | -0.031 | 2 | 0.540 |
CDKL1 |
0.723 | -0.013 | -3 | 0.770 |
PKCB |
0.722 | -0.008 | 2 | 0.454 |
NIK |
0.722 | -0.031 | -3 | 0.858 |
DAPK2 |
0.722 | 0.081 | -3 | 0.838 |
NUAK2 |
0.722 | -0.000 | -3 | 0.817 |
RSK3 |
0.721 | 0.004 | -3 | 0.727 |
ICK |
0.721 | 0.010 | -3 | 0.812 |
CDKL5 |
0.721 | -0.016 | -3 | 0.758 |
CK1D |
0.721 | 0.133 | -3 | 0.628 |
CK2A2 |
0.720 | 0.147 | 1 | 0.396 |
HIPK1 |
0.720 | 0.020 | 1 | 0.155 |
NEK7 |
0.720 | -0.123 | -3 | 0.835 |
ERK1 |
0.720 | -0.018 | 1 | 0.133 |
PKCG |
0.720 | -0.010 | 2 | 0.457 |
TTBK2 |
0.720 | -0.097 | 2 | 0.452 |
P38B |
0.719 | -0.003 | 1 | 0.142 |
MLK4 |
0.719 | -0.006 | 2 | 0.434 |
PKCA |
0.719 | -0.007 | 2 | 0.458 |
MASTL |
0.719 | -0.052 | -2 | 0.835 |
PRKX |
0.719 | 0.071 | -3 | 0.667 |
AMPKA2 |
0.719 | 0.013 | -3 | 0.801 |
CDK13 |
0.719 | -0.033 | 1 | 0.138 |
WNK1 |
0.718 | -0.100 | -2 | 0.879 |
SRPK2 |
0.718 | 0.012 | -3 | 0.637 |
CDK10 |
0.718 | 0.006 | 1 | 0.152 |
PKACB |
0.718 | 0.040 | -2 | 0.657 |
MARK4 |
0.718 | -0.031 | 4 | 0.764 |
CAMLCK |
0.717 | -0.008 | -2 | 0.839 |
HUNK |
0.717 | -0.076 | 2 | 0.506 |
ULK1 |
0.717 | -0.131 | -3 | 0.793 |
PLK1 |
0.717 | 0.065 | -2 | 0.787 |
YSK4 |
0.716 | -0.034 | 1 | 0.207 |
CHAK1 |
0.716 | -0.028 | 2 | 0.578 |
P70S6KB |
0.716 | -0.006 | -3 | 0.760 |
MNK1 |
0.716 | -0.000 | -2 | 0.782 |
CK2A1 |
0.716 | 0.160 | 1 | 0.418 |
CDK16 |
0.716 | -0.003 | 1 | 0.133 |
PDHK1 |
0.716 | -0.187 | 1 | 0.181 |
MST3 |
0.716 | 0.064 | 2 | 0.565 |
P38D |
0.716 | 0.002 | 1 | 0.099 |
TSSK1 |
0.716 | -0.010 | -3 | 0.853 |
PAK1 |
0.715 | -0.034 | -2 | 0.770 |
PHKG1 |
0.715 | -0.052 | -3 | 0.808 |
TSSK2 |
0.715 | -0.012 | -5 | 0.812 |
CK1A2 |
0.715 | 0.116 | -3 | 0.624 |
ALK2 |
0.715 | 0.094 | -2 | 0.830 |
SRPK3 |
0.714 | 0.005 | -3 | 0.695 |
IRE1 |
0.714 | -0.102 | 1 | 0.159 |
BCKDK |
0.714 | -0.143 | -1 | 0.605 |
TLK2 |
0.713 | -0.027 | 1 | 0.183 |
MSK1 |
0.713 | 0.028 | -3 | 0.723 |
CDK12 |
0.713 | -0.036 | 1 | 0.134 |
BRSK1 |
0.713 | 0.017 | -3 | 0.764 |
FAM20C |
0.712 | -0.050 | 2 | 0.342 |
ANKRD3 |
0.712 | -0.098 | 1 | 0.219 |
DYRK4 |
0.712 | -0.020 | 1 | 0.145 |
MNK2 |
0.712 | -0.046 | -2 | 0.772 |
CLK4 |
0.711 | 0.004 | -3 | 0.730 |
NEK9 |
0.711 | -0.151 | 2 | 0.540 |
PKCZ |
0.711 | -0.054 | 2 | 0.501 |
CDK14 |
0.711 | -0.011 | 1 | 0.154 |
PKCH |
0.711 | -0.046 | 2 | 0.433 |
CK1G1 |
0.710 | 0.043 | -3 | 0.659 |
CLK1 |
0.710 | 0.002 | -3 | 0.699 |
QSK |
0.710 | 0.009 | 4 | 0.741 |
P38A |
0.710 | -0.029 | 1 | 0.151 |
MPSK1 |
0.710 | 0.039 | 1 | 0.138 |
SMG1 |
0.709 | -0.057 | 1 | 0.160 |
ATM |
0.709 | -0.071 | 1 | 0.184 |
GSK3A |
0.709 | 0.061 | 4 | 0.518 |
CAMK4 |
0.709 | -0.061 | -3 | 0.798 |
CK1A |
0.709 | 0.172 | -3 | 0.546 |
PKG2 |
0.709 | 0.004 | -2 | 0.659 |
PAK3 |
0.709 | -0.074 | -2 | 0.765 |
RIPK1 |
0.709 | -0.140 | 1 | 0.204 |
MEK1 |
0.709 | 0.004 | 2 | 0.557 |
MSK2 |
0.708 | -0.026 | -3 | 0.720 |
CDK9 |
0.708 | -0.053 | 1 | 0.139 |
PKR |
0.708 | -0.085 | 1 | 0.183 |
CDK2 |
0.708 | -0.022 | 1 | 0.224 |
DCAMKL1 |
0.707 | -0.016 | -3 | 0.761 |
PRKD3 |
0.707 | -0.022 | -3 | 0.703 |
JNK1 |
0.707 | -0.010 | 1 | 0.160 |
TAO3 |
0.707 | 0.030 | 1 | 0.214 |
AURB |
0.707 | 0.001 | -2 | 0.637 |
BRSK2 |
0.706 | -0.044 | -3 | 0.784 |
DYRK1B |
0.706 | -0.014 | 1 | 0.155 |
ERK2 |
0.706 | -0.057 | 1 | 0.146 |
GCK |
0.705 | 0.121 | 1 | 0.261 |
AURA |
0.705 | 0.010 | -2 | 0.610 |
ZAK |
0.705 | -0.062 | 1 | 0.222 |
VRK2 |
0.705 | -0.124 | 1 | 0.197 |
AKT2 |
0.705 | 0.003 | -3 | 0.649 |
MARK3 |
0.705 | 0.011 | 4 | 0.693 |
NIM1 |
0.705 | -0.117 | 3 | 0.726 |
SGK3 |
0.705 | -0.026 | -3 | 0.737 |
DNAPK |
0.704 | -0.079 | 1 | 0.132 |
MYLK4 |
0.704 | 0.012 | -2 | 0.762 |
PLK3 |
0.704 | -0.053 | 2 | 0.480 |
MEKK3 |
0.703 | -0.041 | 1 | 0.241 |
PLK4 |
0.703 | -0.114 | 2 | 0.397 |
DYRK1A |
0.703 | -0.020 | 1 | 0.147 |
IRE2 |
0.703 | -0.103 | 2 | 0.448 |
MELK |
0.703 | -0.072 | -3 | 0.771 |
GSK3B |
0.703 | 0.045 | 4 | 0.511 |
WNK3 |
0.703 | -0.249 | 1 | 0.172 |
HIPK3 |
0.702 | -0.028 | 1 | 0.131 |
PIM2 |
0.702 | 0.014 | -3 | 0.705 |
PAK6 |
0.702 | -0.043 | -2 | 0.677 |
PAK2 |
0.702 | -0.066 | -2 | 0.754 |
MAK |
0.701 | 0.042 | -2 | 0.752 |
NUAK1 |
0.701 | -0.053 | -3 | 0.758 |
SIK |
0.700 | -0.035 | -3 | 0.733 |
NEK2 |
0.700 | -0.137 | 2 | 0.550 |
PRP4 |
0.700 | -0.020 | -3 | 0.748 |
QIK |
0.699 | -0.086 | -3 | 0.808 |
MEK5 |
0.699 | -0.092 | 2 | 0.536 |
NEK11 |
0.698 | -0.026 | 1 | 0.230 |
GAK |
0.698 | 0.018 | 1 | 0.209 |
CHK1 |
0.698 | -0.027 | -3 | 0.809 |
PKCE |
0.697 | -0.012 | 2 | 0.450 |
CAMK1G |
0.697 | -0.053 | -3 | 0.718 |
HPK1 |
0.697 | 0.058 | 1 | 0.252 |
SSTK |
0.696 | -0.033 | 4 | 0.726 |
MEKK2 |
0.696 | -0.093 | 2 | 0.505 |
TLK1 |
0.696 | -0.100 | -2 | 0.844 |
ERK7 |
0.696 | -0.041 | 2 | 0.352 |
DCAMKL2 |
0.696 | -0.053 | -3 | 0.772 |
CDK6 |
0.695 | -0.033 | 1 | 0.128 |
PKCT |
0.694 | -0.080 | 2 | 0.445 |
PERK |
0.694 | -0.130 | -2 | 0.833 |
MARK2 |
0.694 | -0.033 | 4 | 0.656 |
BUB1 |
0.694 | 0.073 | -5 | 0.756 |
PKACA |
0.693 | 0.003 | -2 | 0.606 |
MEKK1 |
0.693 | -0.141 | 1 | 0.182 |
NEK5 |
0.693 | -0.116 | 1 | 0.176 |
SNRK |
0.692 | -0.141 | 2 | 0.444 |
DYRK3 |
0.692 | -0.042 | 1 | 0.151 |
MAP3K15 |
0.692 | -0.038 | 1 | 0.192 |
LKB1 |
0.692 | 0.011 | -3 | 0.826 |
TNIK |
0.692 | -0.002 | 3 | 0.847 |
TTBK1 |
0.691 | -0.130 | 2 | 0.396 |
AKT1 |
0.691 | -0.024 | -3 | 0.673 |
IRAK4 |
0.691 | -0.144 | 1 | 0.149 |
MAPKAPK5 |
0.691 | -0.092 | -3 | 0.676 |
DAPK1 |
0.691 | 0.069 | -3 | 0.758 |
KHS2 |
0.691 | 0.041 | 1 | 0.218 |
MST2 |
0.691 | -0.024 | 1 | 0.230 |
BRAF |
0.690 | -0.085 | -4 | 0.732 |
MINK |
0.690 | -0.011 | 1 | 0.200 |
MARK1 |
0.690 | -0.032 | 4 | 0.705 |
PLK2 |
0.690 | 0.001 | -3 | 0.774 |
KHS1 |
0.690 | 0.018 | 1 | 0.187 |
DAPK3 |
0.689 | 0.034 | -3 | 0.776 |
HGK |
0.689 | -0.035 | 3 | 0.846 |
P70S6K |
0.689 | -0.036 | -3 | 0.662 |
PKCI |
0.688 | -0.071 | 2 | 0.469 |
PINK1 |
0.688 | -0.121 | 1 | 0.159 |
SLK |
0.688 | -0.018 | -2 | 0.724 |
MOK |
0.687 | 0.003 | 1 | 0.148 |
YANK3 |
0.687 | 0.002 | 2 | 0.273 |
CDK4 |
0.687 | -0.049 | 1 | 0.126 |
PHKG2 |
0.687 | -0.107 | -3 | 0.757 |
EEF2K |
0.687 | -0.037 | 3 | 0.823 |
PDK1 |
0.687 | -0.070 | 1 | 0.176 |
SMMLCK |
0.687 | -0.024 | -3 | 0.779 |
PAK5 |
0.686 | -0.062 | -2 | 0.625 |
AKT3 |
0.686 | -0.001 | -3 | 0.591 |
HRI |
0.685 | -0.195 | -2 | 0.838 |
NEK8 |
0.685 | -0.124 | 2 | 0.524 |
TAK1 |
0.685 | -0.042 | 1 | 0.216 |
TAO2 |
0.685 | -0.084 | 2 | 0.552 |
WNK4 |
0.685 | -0.180 | -2 | 0.870 |
STK33 |
0.684 | -0.091 | 2 | 0.404 |
PAK4 |
0.684 | -0.057 | -2 | 0.632 |
CAMK1D |
0.684 | -0.029 | -3 | 0.648 |
MEKK6 |
0.684 | -0.099 | 1 | 0.189 |
CAMKK2 |
0.683 | -0.057 | -2 | 0.761 |
LOK |
0.683 | -0.058 | -2 | 0.766 |
PBK |
0.683 | -0.023 | 1 | 0.140 |
CAMKK1 |
0.683 | -0.102 | -2 | 0.765 |
MST1 |
0.683 | -0.045 | 1 | 0.209 |
OSR1 |
0.682 | 0.008 | 2 | 0.535 |
ROCK2 |
0.680 | -0.006 | -3 | 0.766 |
PDHK3_TYR |
0.680 | 0.217 | 4 | 0.845 |
PKN1 |
0.679 | -0.068 | -3 | 0.677 |
SGK1 |
0.678 | -0.006 | -3 | 0.573 |
NEK4 |
0.678 | -0.138 | 1 | 0.166 |
MRCKA |
0.678 | -0.021 | -3 | 0.720 |
LRRK2 |
0.677 | -0.101 | 2 | 0.558 |
YSK1 |
0.677 | -0.094 | 2 | 0.532 |
CHK2 |
0.676 | -0.023 | -3 | 0.586 |
VRK1 |
0.676 | -0.117 | 2 | 0.516 |
HASPIN |
0.676 | -0.038 | -1 | 0.556 |
PDHK4_TYR |
0.676 | 0.169 | 2 | 0.593 |
TXK |
0.675 | 0.239 | 1 | 0.382 |
NEK1 |
0.673 | -0.127 | 1 | 0.166 |
BMPR2_TYR |
0.673 | 0.163 | -1 | 0.691 |
MAP2K6_TYR |
0.672 | 0.154 | -1 | 0.693 |
MRCKB |
0.672 | -0.044 | -3 | 0.701 |
TESK1_TYR |
0.671 | 0.082 | 3 | 0.850 |
IRAK1 |
0.670 | -0.221 | -1 | 0.568 |
PDHK1_TYR |
0.670 | 0.129 | -1 | 0.703 |
MAP2K4_TYR |
0.670 | 0.118 | -1 | 0.679 |
CAMK1A |
0.669 | -0.048 | -3 | 0.612 |
TTK |
0.667 | -0.026 | -2 | 0.812 |
DMPK1 |
0.667 | -0.007 | -3 | 0.722 |
CRIK |
0.666 | -0.004 | -3 | 0.673 |
ASK1 |
0.665 | -0.086 | 1 | 0.188 |
LIMK2_TYR |
0.665 | 0.022 | -3 | 0.869 |
BIKE |
0.664 | -0.056 | 1 | 0.146 |
FGR |
0.664 | 0.088 | 1 | 0.249 |
PKMYT1_TYR |
0.663 | 0.005 | 3 | 0.806 |
MEK2 |
0.663 | -0.164 | 2 | 0.541 |
MYO3B |
0.663 | -0.062 | 2 | 0.567 |
SBK |
0.662 | -0.025 | -3 | 0.520 |
MYO3A |
0.662 | -0.064 | 1 | 0.177 |
MAP2K7_TYR |
0.662 | -0.095 | 2 | 0.566 |
AAK1 |
0.661 | -0.019 | 1 | 0.106 |
YANK2 |
0.661 | 0.002 | 2 | 0.268 |
RIPK2 |
0.661 | -0.204 | 1 | 0.191 |
EPHA6 |
0.661 | 0.014 | -1 | 0.676 |
PTK2 |
0.660 | 0.170 | -1 | 0.661 |
ROCK1 |
0.660 | -0.052 | -3 | 0.718 |
CK1G3 |
0.659 | 0.051 | -3 | 0.503 |
PINK1_TYR |
0.658 | -0.103 | 1 | 0.214 |
EPHB4 |
0.658 | 0.018 | -1 | 0.635 |
TAO1 |
0.657 | -0.109 | 1 | 0.158 |
SYK |
0.657 | 0.130 | -1 | 0.633 |
ALPHAK3 |
0.656 | -0.060 | -1 | 0.594 |
PKG1 |
0.656 | -0.071 | -2 | 0.566 |
ITK |
0.656 | 0.074 | -1 | 0.603 |
RET |
0.656 | -0.120 | 1 | 0.171 |
STLK3 |
0.656 | -0.100 | 1 | 0.200 |
JAK3 |
0.653 | -0.069 | 1 | 0.190 |
NEK3 |
0.653 | -0.200 | 1 | 0.137 |
CK1G2 |
0.653 | 0.070 | -3 | 0.589 |
LCK |
0.653 | 0.024 | -1 | 0.667 |
SRMS |
0.652 | 0.059 | 1 | 0.309 |
FER |
0.652 | 0.011 | 1 | 0.263 |
INSRR |
0.652 | 0.024 | 3 | 0.680 |
ABL2 |
0.652 | -0.022 | -1 | 0.610 |
ROS1 |
0.652 | -0.041 | 3 | 0.711 |
BMX |
0.652 | 0.063 | -1 | 0.538 |
YES1 |
0.652 | -0.010 | -1 | 0.681 |
CSF1R |
0.652 | -0.063 | 3 | 0.721 |
TYRO3 |
0.651 | -0.066 | 3 | 0.746 |
FYN |
0.651 | 0.054 | -1 | 0.668 |
EPHB1 |
0.651 | 0.030 | 1 | 0.294 |
EPHA4 |
0.651 | 0.005 | 2 | 0.494 |
LIMK1_TYR |
0.650 | -0.119 | 2 | 0.562 |
NEK10_TYR |
0.650 | -0.074 | 1 | 0.126 |
JAK1 |
0.649 | -0.024 | 1 | 0.156 |
TYK2 |
0.649 | -0.171 | 1 | 0.154 |
MET |
0.649 | -0.005 | 3 | 0.717 |
JAK2 |
0.649 | -0.136 | 1 | 0.156 |
BLK |
0.648 | 0.006 | -1 | 0.660 |
KIT |
0.648 | -0.053 | 3 | 0.729 |
ABL1 |
0.647 | -0.050 | -1 | 0.603 |
TNK2 |
0.647 | -0.034 | 3 | 0.688 |
MST1R |
0.647 | -0.145 | 3 | 0.746 |
HCK |
0.647 | -0.031 | -1 | 0.652 |
FLT1 |
0.647 | -0.041 | -1 | 0.650 |
MERTK |
0.646 | 0.010 | 3 | 0.699 |
DDR1 |
0.646 | -0.134 | 4 | 0.764 |
PTK2B |
0.645 | 0.098 | -1 | 0.579 |
EPHB2 |
0.644 | -0.014 | -1 | 0.612 |
PDGFRB |
0.644 | -0.108 | 3 | 0.746 |
EPHB3 |
0.644 | -0.041 | -1 | 0.620 |
KDR |
0.644 | -0.087 | 3 | 0.682 |
EGFR |
0.643 | -0.039 | 1 | 0.212 |
TNNI3K_TYR |
0.643 | -0.095 | 1 | 0.149 |
ZAP70 |
0.643 | 0.048 | -1 | 0.566 |
FGFR2 |
0.642 | -0.127 | 3 | 0.734 |
EPHA7 |
0.642 | -0.009 | 2 | 0.489 |
TEC |
0.641 | -0.003 | -1 | 0.528 |
ERBB2 |
0.639 | -0.074 | 1 | 0.217 |
WEE1_TYR |
0.639 | -0.064 | -1 | 0.563 |
TNK1 |
0.638 | -0.109 | 3 | 0.724 |
NTRK3 |
0.638 | -0.017 | -1 | 0.603 |
AXL |
0.638 | -0.078 | 3 | 0.704 |
ERBB4 |
0.638 | 0.021 | 1 | 0.270 |
PTK6 |
0.637 | -0.094 | -1 | 0.552 |
SRC |
0.637 | -0.003 | -1 | 0.651 |
FGFR3 |
0.637 | -0.099 | 3 | 0.700 |
ALK |
0.637 | -0.047 | 3 | 0.646 |
EPHA8 |
0.637 | -0.005 | -1 | 0.618 |
FLT3 |
0.636 | -0.164 | 3 | 0.741 |
NTRK1 |
0.636 | -0.068 | -1 | 0.633 |
FGFR1 |
0.636 | -0.153 | 3 | 0.695 |
EPHA3 |
0.635 | -0.056 | 2 | 0.473 |
INSR |
0.635 | -0.057 | 3 | 0.656 |
MATK |
0.635 | -0.045 | -1 | 0.553 |
FRK |
0.635 | -0.077 | -1 | 0.635 |
PDGFRA |
0.635 | -0.165 | 3 | 0.744 |
BTK |
0.634 | -0.114 | -1 | 0.571 |
EPHA5 |
0.633 | -0.033 | 2 | 0.468 |
DDR2 |
0.633 | -0.059 | 3 | 0.662 |
TEK |
0.632 | -0.144 | 3 | 0.674 |
LTK |
0.631 | -0.108 | 3 | 0.666 |
FGFR4 |
0.630 | -0.073 | -1 | 0.581 |
NTRK2 |
0.630 | -0.110 | 3 | 0.680 |
LYN |
0.629 | -0.059 | 3 | 0.649 |
EPHA2 |
0.629 | -0.006 | -1 | 0.590 |
EPHA1 |
0.629 | -0.110 | 3 | 0.693 |
FLT4 |
0.628 | -0.153 | 3 | 0.679 |
CSK |
0.626 | -0.092 | 2 | 0.494 |
IGF1R |
0.625 | -0.031 | 3 | 0.596 |
MUSK |
0.623 | -0.100 | 1 | 0.191 |
FES |
0.619 | 0.036 | -1 | 0.525 |