Motif 372 (n=97)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2618 | ochoa | Snf2 related CREBBP activator protein | None |
| O14681 | EI24 | S318 | ochoa | Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) | Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}. |
| O15550 | KDM6A | S761 | ochoa | Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17761849, PubMed:17851529). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17713478, PubMed:17761849, PubMed:17851529). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}. |
| O43159 | RRP8 | S124 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O60285 | NUAK1 | S388 | ochoa | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O60499 | STX10 | S132 | ochoa | Syntaxin-10 (Syn10) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O60664 | PLIN3 | S383 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60684 | KPNA6 | S459 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O75665 | OFD1 | S61 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O94988 | FAM13A | S527 | ochoa | Protein FAM13A | None |
| O95251 | KAT7 | S136 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95453 | PARN | S570 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| P01275 | GCG | S150 | ochoa | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] | [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
| P08238 | HSP90AB1 | S468 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P21333 | FLNA | S2327 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21730 | C5AR1 | S332 | psp | C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
| P24821 | TNC | S70 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P32926 | DSG3 | S874 | ochoa | Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}. |
| P33241 | LSP1 | S111 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P36551 | CPOX | S344 | ochoa | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) | Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX and participates to the sixth step in the heme biosynthetic pathway. {ECO:0000269|PubMed:8159699}. |
| P38398 | BRCA1 | Y1522 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P43243 | MATR3 | S604 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P48681 | NES | S323 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49019 | HCAR3 | S326 | ochoa | Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2) | Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:19561068}. |
| P52799 | EFNB2 | S268 | ochoa | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}. |
| P61604 | HSPE1 | S51 | ochoa | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}. |
| P67809 | YBX1 | S165 | ochoa|psp | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P78364 | PHC1 | S786 | ochoa | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. {ECO:0000269|PubMed:23418308}. |
| P78559 | MAP1A | S1152 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P85299 | PRR5 | S252 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| P98171 | ARHGAP4 | S408 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q07666 | KHDRBS1 | S388 | psp | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q08495 | DMTN | S307 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q08AD1 | CAMSAP2 | S1311 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q13023 | AKAP6 | S1653 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Q13136 | PPFIA1 | S242 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13761 | RUNX3 | S218 | ochoa | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q15149 | PLEC | S2755 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15233 | NONO | S147 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q16513 | PKN2 | S620 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16656 | NRF1 | S136 | ochoa|psp | Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) | Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. |
| Q32P44 | EML3 | S184 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q4ZG55 | GREB1 | S320 | ochoa | Protein GREB1 (Gene regulated in breast cancer 1 protein) | May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. |
| Q5BKX6 | SLC45A4 | S346 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5SYE7 | NHSL1 | S1467 | ochoa | NHS-like protein 1 | None |
| Q5T0Z8 | C6orf132 | S1085 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T5P2 | KIAA1217 | S1794 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q6DT37 | CDC42BPG | S1512 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6IQ55 | TTBK2 | S577 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6NZI2 | CAVIN1 | S26 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P2E9 | EDC4 | S583 | ochoa|psp | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6ZRS2 | SRCAP | S2795 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZVH7 | ESPNL | S370 | ochoa | Espin-like protein | Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}. |
| Q7Z2W4 | ZC3HAV1 | S353 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z401 | DENND4A | S1509 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z6J6 | FRMD5 | S394 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q7Z6Z7 | HUWE1 | S2370 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S3816 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86WB0 | ZC3HC1 | S479 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86YN6 | PPARGC1B | S992 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Q8N2R8 | FAM43A | S389 | ochoa | Protein FAM43A | None |
| Q8NF99 | ZNF397 | S142 | ochoa | Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47) | Isoform 3 acts as a DNA-dependent transcriptional repressor. {ECO:0000269|PubMed:12801647}. |
| Q8TDS4 | HCAR2 | S326 | ochoa | Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor) | Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}. |
| Q8TEV9 | SMCR8 | S400 | ochoa|psp | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WWI1 | LMO7 | S1018 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92854 | SEMA4D | S798 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q96BK5 | PINX1 | S161 | ochoa | PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) | Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}. |
| Q96DZ5 | CLIP3 | S402 | ochoa | CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) | Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269|PubMed:19139280}. |
| Q96NY9 | MUS81 | S95 | ochoa | Structure-specific endonuclease subunit MUS81 (EC 3.1.22.-) (Crossover junction endonuclease MUS81) (MUS81 endonuclease homolog) | Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability (PubMed:11741546, PubMed:12374758, PubMed:12686547, PubMed:12721304, PubMed:24371268, PubMed:24733841, PubMed:24813886, PubMed:35290797, PubMed:39015284). Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs (PubMed:24371268, PubMed:24733841, PubMed:35290797). MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing (PubMed:24813886). Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork (PubMed:24813886). MUS81-EME2 could also function in telomere maintenance (PubMed:24813886). MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination (PubMed:11741546, PubMed:12374758, PubMed:14617801, PubMed:15805243, PubMed:24813886). {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:24371268, ECO:0000269|PubMed:24733841, ECO:0000269|PubMed:24813886, ECO:0000269|PubMed:35290797, ECO:0000269|PubMed:39015284}. |
| Q96PE2 | ARHGEF17 | S418 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PY5 | FMNL2 | S1016 | ochoa|psp | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96R06 | SPAG5 | S197 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RT1 | ERBIN | S870 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99624 | SLC38A3 | S52 | ochoa | Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) | Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10823827). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10823827}. |
| Q99759 | MAP3K3 | S312 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q99767 | APBA2 | S236 | psp | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Q9BVJ6 | UTP14A | S451 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BZF1 | OSBPL8 | S91 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9H0E9 | BRD8 | S585 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9H1A4 | ANAPC1 | S1347 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H501 | ESF1 | S198 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9HAS0 | C17orf75 | S59 | ochoa | Protein Njmu-R1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}. |
| Q9HCC9 | ZFYVE28 | S392 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9NPI1 | BRD7 | S289 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NWQ8 | PAG1 | S351 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NYB0 | TERF2IP | S105 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9NYL2 | MAP3K20 | S591 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P270 | SLAIN2 | S431 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9UH99 | SUN2 | S30 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UHD8 | SEPTIN9 | S30 | ochoa|psp | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9ULH0 | KIDINS220 | S1631 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9UMS6 | SYNPO2 | S202 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9Y2L6 | FRMD4B | S774 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y4D8 | HECTD4 | S1073 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4G8 | RAPGEF2 | S1223 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| S4R3N1 | HSPE1-MOB4 | S51 | ochoa | 10 kDa heat shock protein, mitochondrial (10 kDa chaperonin) (Chaperonin 10) (MOB-like protein phocein) (Mob1 homolog 3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. {ECO:0000256|ARBA:ARBA00046093}.; FUNCTION: Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000256|ARBA:ARBA00044741}. |
| Q8TEW0 | PARD3 | S728 | Sugiyama | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.000071 | 4.146 |
| R-HSA-3296197 | Hydroxycarboxylic acid-binding receptors | 0.001001 | 2.999 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.002431 | 2.614 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.003517 | 2.454 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.012957 | 1.887 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.012957 | 1.887 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.012957 | 1.887 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.019373 | 1.713 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.025748 | 1.589 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.025748 | 1.589 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.025748 | 1.589 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.025748 | 1.589 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.025748 | 1.589 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.025748 | 1.589 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.025748 | 1.589 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.025748 | 1.589 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.025748 | 1.589 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.025748 | 1.589 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.025748 | 1.589 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.025748 | 1.589 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.038375 | 1.416 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.038375 | 1.416 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.050839 | 1.294 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.050839 | 1.294 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.063144 | 1.200 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.063144 | 1.200 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.069237 | 1.160 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.069237 | 1.160 |
| R-HSA-170984 | ARMS-mediated activation | 0.075290 | 1.123 |
| R-HSA-9613354 | Lipophagy | 0.075290 | 1.123 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.081305 | 1.090 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.093218 | 1.030 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.093218 | 1.030 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.099117 | 1.004 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.116588 | 0.933 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.116588 | 0.933 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.116588 | 0.933 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.122336 | 0.912 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.122336 | 0.912 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.133722 | 0.874 |
| R-HSA-3928664 | Ephrin signaling | 0.139360 | 0.856 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.144962 | 0.839 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.144962 | 0.839 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.144962 | 0.839 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.150528 | 0.822 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.150528 | 0.822 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.150528 | 0.822 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.150528 | 0.822 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.156057 | 0.807 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.183176 | 0.737 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.193780 | 0.713 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.193780 | 0.713 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.204247 | 0.690 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.204247 | 0.690 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.264285 | 0.578 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.297212 | 0.527 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.297212 | 0.527 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.136738 | 0.864 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.036701 | 1.435 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.093218 | 1.030 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.128048 | 0.893 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.273846 | 0.562 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.199030 | 0.701 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.249710 | 0.603 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.010104 | 1.996 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.234849 | 0.629 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.028455 | 1.546 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.287956 | 0.541 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.232089 | 0.634 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.232089 | 0.634 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.232089 | 0.634 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.116588 | 0.933 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.027163 | 1.566 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.264285 | 0.578 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.099117 | 1.004 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.183176 | 0.737 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.057011 | 1.244 |
| R-HSA-1221632 | Meiotic synapsis | 0.007645 | 2.117 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.133722 | 0.874 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.183176 | 0.737 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.224780 | 0.648 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.198731 | 0.702 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.086539 | 1.063 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.050839 | 1.294 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.063144 | 1.200 |
| R-HSA-5693538 | Homology Directed Repair | 0.212965 | 0.672 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.099117 | 1.004 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.110802 | 0.955 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.128048 | 0.893 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.139360 | 0.856 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.020846 | 1.681 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.193780 | 0.713 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.234849 | 0.629 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.042645 | 1.370 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.054799 | 1.261 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.135615 | 0.868 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.044627 | 1.350 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.150528 | 0.822 |
| R-HSA-3371511 | HSF1 activation | 0.244789 | 0.611 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.264285 | 0.578 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.264285 | 0.578 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.209430 | 0.679 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.167010 | 0.777 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.254600 | 0.594 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.017747 | 1.751 |
| R-HSA-1500620 | Meiosis | 0.023348 | 1.632 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.204247 | 0.690 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.087281 | 1.059 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.116588 | 0.933 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.128048 | 0.893 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.128048 | 0.893 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.156057 | 0.807 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.177822 | 0.750 |
| R-HSA-420029 | Tight junction interactions | 0.183176 | 0.737 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.209430 | 0.679 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.229831 | 0.639 |
| R-HSA-373755 | Semaphorin interactions | 0.078839 | 1.103 |
| R-HSA-169893 | Prolonged ERK activation events | 0.122336 | 0.912 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.177822 | 0.750 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.050541 | 1.296 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.193780 | 0.713 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.239835 | 0.620 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.072254 | 1.141 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.224780 | 0.648 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.139360 | 0.856 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.063144 | 1.200 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.081305 | 1.090 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.116588 | 0.933 |
| R-HSA-429947 | Deadenylation of mRNA | 0.177822 | 0.750 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.188495 | 0.725 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.204247 | 0.690 |
| R-HSA-416700 | Other semaphorin interactions | 0.116588 | 0.933 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.144962 | 0.839 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.229831 | 0.639 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.239835 | 0.620 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.249710 | 0.603 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.224780 | 0.648 |
| R-HSA-73927 | Depurination | 0.254600 | 0.594 |
| R-HSA-9675135 | Diseases of DNA repair | 0.297212 | 0.527 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.063144 | 1.200 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.075290 | 1.123 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.110802 | 0.955 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.122336 | 0.912 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.071371 | 1.146 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.219697 | 0.658 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.219697 | 0.658 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.224780 | 0.648 |
| R-HSA-3371568 | Attenuation phase | 0.264285 | 0.578 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.122336 | 0.912 |
| R-HSA-9945266 | Differentiation of T cells | 0.122336 | 0.912 |
| R-HSA-187687 | Signalling to ERKs | 0.239835 | 0.620 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.019071 | 1.720 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.145636 | 0.837 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.122336 | 0.912 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.188495 | 0.725 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.278580 | 0.555 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.127969 | 0.893 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.183176 | 0.737 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.183176 | 0.737 |
| R-HSA-622312 | Inflammasomes | 0.199030 | 0.701 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.199030 | 0.701 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.209430 | 0.679 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.264285 | 0.578 |
| R-HSA-5260271 | Diseases of Immune System | 0.264285 | 0.578 |
| R-HSA-1474165 | Reproduction | 0.070849 | 1.150 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.167010 | 0.777 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.292599 | 0.534 |
| R-HSA-3214847 | HATs acetylate histones | 0.161484 | 0.792 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.297212 | 0.527 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.297212 | 0.527 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.112974 | 0.947 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.156057 | 0.807 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.186965 | 0.728 |
| R-HSA-8939211 | ESR-mediated signaling | 0.088029 | 1.055 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.018262 | 1.738 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.210585 | 0.677 |
| R-HSA-3214842 | HDMs demethylate histones | 0.017747 | 1.751 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.075290 | 1.123 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.122336 | 0.912 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.193780 | 0.713 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.229831 | 0.639 |
| R-HSA-2559583 | Cellular Senescence | 0.141320 | 0.850 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.069237 | 1.160 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.075290 | 1.123 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.116588 | 0.933 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.139360 | 0.856 |
| R-HSA-180292 | GAB1 signalosome | 0.139360 | 0.856 |
| R-HSA-381042 | PERK regulates gene expression | 0.239835 | 0.620 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.249710 | 0.603 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.269081 | 0.570 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.029623 | 1.528 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.156923 | 0.804 |
| R-HSA-2262752 | Cellular responses to stress | 0.140312 | 0.853 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.172989 | 0.762 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.269081 | 0.570 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.270443 | 0.568 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.077599 | 1.110 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.240547 | 0.619 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.271965 | 0.565 |
| R-HSA-8983711 | OAS antiviral response | 0.099117 | 1.004 |
| R-HSA-3000170 | Syndecan interactions | 0.172433 | 0.763 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.239835 | 0.620 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.269081 | 0.570 |
| R-HSA-4839726 | Chromatin organization | 0.031888 | 1.496 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.198731 | 0.702 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.182288 | 0.739 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.123637 | 0.908 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.188495 | 0.725 |
| R-HSA-163560 | Triglyceride catabolism | 0.244789 | 0.611 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.182288 | 0.739 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.172433 | 0.763 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.025896 | 1.587 |
| R-HSA-189451 | Heme biosynthesis | 0.273846 | 0.562 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.278580 | 0.555 |
| R-HSA-73928 | Depyrimidination | 0.278580 | 0.555 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.297212 | 0.527 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.234849 | 0.629 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.085200 | 1.070 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.098744 | 1.005 |
| R-HSA-162582 | Signal Transduction | 0.019179 | 1.717 |
| R-HSA-75153 | Apoptotic execution phase | 0.048922 | 1.310 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.244789 | 0.611 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.259458 | 0.586 |
| R-HSA-109581 | Apoptosis | 0.113864 | 0.944 |
| R-HSA-5357801 | Programmed Cell Death | 0.182006 | 0.740 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.259458 | 0.586 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.299484 | 0.524 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.301795 | 0.520 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.301795 | 0.520 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.306349 | 0.514 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.306349 | 0.514 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.306349 | 0.514 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.306685 | 0.513 |
| R-HSA-69306 | DNA Replication | 0.306685 | 0.513 |
| R-HSA-446728 | Cell junction organization | 0.307779 | 0.512 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.309082 | 0.510 |
| R-HSA-73887 | Death Receptor Signaling | 0.309082 | 0.510 |
| R-HSA-1989781 | PPARA activates gene expression | 0.311478 | 0.507 |
| R-HSA-9612973 | Autophagy | 0.313872 | 0.503 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.316264 | 0.500 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.319833 | 0.495 |
| R-HSA-912446 | Meiotic recombination | 0.319833 | 0.495 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.323430 | 0.490 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.324270 | 0.489 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.324270 | 0.489 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.324270 | 0.489 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.328679 | 0.483 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.328679 | 0.483 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.333058 | 0.477 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.333058 | 0.477 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.337410 | 0.472 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.337410 | 0.472 |
| R-HSA-1640170 | Cell Cycle | 0.339829 | 0.469 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.341733 | 0.466 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.341733 | 0.466 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.341733 | 0.466 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.341733 | 0.466 |
| R-HSA-75893 | TNF signaling | 0.341733 | 0.466 |
| R-HSA-177929 | Signaling by EGFR | 0.341733 | 0.466 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.350296 | 0.456 |
| R-HSA-180786 | Extension of Telomeres | 0.354536 | 0.450 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.354536 | 0.450 |
| R-HSA-8979227 | Triglyceride metabolism | 0.354536 | 0.450 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.354536 | 0.450 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.354536 | 0.450 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.358749 | 0.445 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.358749 | 0.445 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.362935 | 0.440 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.367093 | 0.435 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.367093 | 0.435 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.367093 | 0.435 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.371224 | 0.430 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.371224 | 0.430 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.371224 | 0.430 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.371224 | 0.430 |
| R-HSA-8848021 | Signaling by PTK6 | 0.371224 | 0.430 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.375329 | 0.426 |
| R-HSA-1500931 | Cell-Cell communication | 0.375378 | 0.426 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.379407 | 0.421 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.383459 | 0.416 |
| R-HSA-69275 | G2/M Transition | 0.386881 | 0.412 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.387485 | 0.412 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.387485 | 0.412 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.387742 | 0.411 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.391485 | 0.407 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.391485 | 0.407 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.391488 | 0.407 |
| R-HSA-5617833 | Cilium Assembly | 0.396079 | 0.402 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.399406 | 0.399 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.403329 | 0.394 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.403329 | 0.394 |
| R-HSA-3000178 | ECM proteoglycans | 0.403329 | 0.394 |
| R-HSA-189445 | Metabolism of porphyrins | 0.403329 | 0.394 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.407226 | 0.390 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.411098 | 0.386 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.411098 | 0.386 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.411098 | 0.386 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.414945 | 0.382 |
| R-HSA-380287 | Centrosome maturation | 0.418767 | 0.378 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.418767 | 0.378 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.418795 | 0.378 |
| R-HSA-74160 | Gene expression (Transcription) | 0.423959 | 0.373 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.425528 | 0.371 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.430085 | 0.366 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.430085 | 0.366 |
| R-HSA-216083 | Integrin cell surface interactions | 0.430085 | 0.366 |
| R-HSA-9659379 | Sensory processing of sound | 0.433809 | 0.363 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.437509 | 0.359 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.441185 | 0.355 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.444837 | 0.352 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.449865 | 0.347 |
| R-HSA-212436 | Generic Transcription Pathway | 0.450633 | 0.346 |
| R-HSA-73894 | DNA Repair | 0.451947 | 0.345 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.452070 | 0.345 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.455652 | 0.341 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.459211 | 0.338 |
| R-HSA-8951664 | Neddylation | 0.467202 | 0.330 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.469748 | 0.328 |
| R-HSA-9663891 | Selective autophagy | 0.469748 | 0.328 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.476660 | 0.322 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.476660 | 0.322 |
| R-HSA-73884 | Base Excision Repair | 0.476660 | 0.322 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.486861 | 0.313 |
| R-HSA-1474290 | Collagen formation | 0.493552 | 0.307 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.496865 | 0.304 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.506676 | 0.295 |
| R-HSA-157579 | Telomere Maintenance | 0.506676 | 0.295 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.509904 | 0.293 |
| R-HSA-422356 | Regulation of insulin secretion | 0.509904 | 0.293 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.510103 | 0.292 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.513111 | 0.290 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.516297 | 0.287 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.516297 | 0.287 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.519463 | 0.284 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.522608 | 0.282 |
| R-HSA-418594 | G alpha (i) signalling events | 0.530894 | 0.275 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.531921 | 0.274 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.531921 | 0.274 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.534985 | 0.272 |
| R-HSA-69239 | Synthesis of DNA | 0.541054 | 0.267 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.543027 | 0.265 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.544059 | 0.264 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.547045 | 0.262 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.550011 | 0.260 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.550011 | 0.260 |
| R-HSA-202403 | TCR signaling | 0.550011 | 0.260 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.558795 | 0.253 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.564556 | 0.248 |
| R-HSA-500792 | GPCR ligand binding | 0.565840 | 0.247 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.567409 | 0.246 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.569616 | 0.244 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.570243 | 0.244 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.575856 | 0.240 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.578635 | 0.238 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.581396 | 0.236 |
| R-HSA-73886 | Chromosome Maintenance | 0.586865 | 0.231 |
| R-HSA-3371556 | Cellular response to heat stress | 0.586865 | 0.231 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.592263 | 0.227 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.594936 | 0.226 |
| R-HSA-388396 | GPCR downstream signalling | 0.596217 | 0.225 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.596567 | 0.224 |
| R-HSA-977606 | Regulation of Complement cascade | 0.597591 | 0.224 |
| R-HSA-194138 | Signaling by VEGF | 0.600230 | 0.222 |
| R-HSA-69481 | G2/M Checkpoints | 0.605455 | 0.218 |
| R-HSA-114608 | Platelet degranulation | 0.605455 | 0.218 |
| R-HSA-6798695 | Neutrophil degranulation | 0.606088 | 0.217 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.608042 | 0.216 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.611146 | 0.214 |
| R-HSA-1483257 | Phospholipid metabolism | 0.611146 | 0.214 |
| R-HSA-9843745 | Adipogenesis | 0.618223 | 0.209 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.623215 | 0.205 |
| R-HSA-163685 | Integration of energy metabolism | 0.633006 | 0.199 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.635414 | 0.197 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.637807 | 0.195 |
| R-HSA-6807070 | PTEN Regulation | 0.640183 | 0.194 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.640183 | 0.194 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.644891 | 0.191 |
| R-HSA-1632852 | Macroautophagy | 0.644891 | 0.191 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.649537 | 0.187 |
| R-HSA-166658 | Complement cascade | 0.656395 | 0.183 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.663119 | 0.178 |
| R-HSA-166520 | Signaling by NTRKs | 0.663119 | 0.178 |
| R-HSA-69242 | S Phase | 0.663119 | 0.178 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.667529 | 0.176 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.669713 | 0.174 |
| R-HSA-1474244 | Extracellular matrix organization | 0.669826 | 0.174 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.671882 | 0.173 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.676178 | 0.170 |
| R-HSA-372790 | Signaling by GPCR | 0.683528 | 0.165 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.686286 | 0.163 |
| R-HSA-877300 | Interferon gamma signaling | 0.686678 | 0.163 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.696839 | 0.157 |
| R-HSA-1280218 | Adaptive Immune System | 0.702507 | 0.153 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.710520 | 0.148 |
| R-HSA-418555 | G alpha (s) signalling events | 0.712424 | 0.147 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.718061 | 0.144 |
| R-HSA-422475 | Axon guidance | 0.718110 | 0.144 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.734324 | 0.134 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.739536 | 0.131 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.740922 | 0.130 |
| R-HSA-68886 | M Phase | 0.741839 | 0.130 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.742954 | 0.129 |
| R-HSA-913531 | Interferon Signaling | 0.743084 | 0.129 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.747998 | 0.126 |
| R-HSA-68877 | Mitotic Prometaphase | 0.751306 | 0.124 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.752944 | 0.123 |
| R-HSA-9675108 | Nervous system development | 0.757315 | 0.121 |
| R-HSA-72172 | mRNA Splicing | 0.770270 | 0.113 |
| R-HSA-6805567 | Keratinization | 0.773289 | 0.112 |
| R-HSA-68882 | Mitotic Anaphase | 0.787801 | 0.104 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.789201 | 0.103 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.801393 | 0.096 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.804006 | 0.095 |
| R-HSA-72312 | rRNA processing | 0.809130 | 0.092 |
| R-HSA-8953854 | Metabolism of RNA | 0.815018 | 0.089 |
| R-HSA-199991 | Membrane Trafficking | 0.816364 | 0.088 |
| R-HSA-157118 | Signaling by NOTCH | 0.818984 | 0.087 |
| R-HSA-112316 | Neuronal System | 0.831706 | 0.080 |
| R-HSA-421270 | Cell-cell junction organization | 0.831716 | 0.080 |
| R-HSA-5688426 | Deubiquitination | 0.836122 | 0.078 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.837205 | 0.077 |
| R-HSA-416476 | G alpha (q) signalling events | 0.845622 | 0.073 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.849668 | 0.071 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.855540 | 0.068 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.859327 | 0.066 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.860259 | 0.065 |
| R-HSA-9658195 | Leishmania infection | 0.862104 | 0.064 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.862104 | 0.064 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.869244 | 0.061 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.875191 | 0.058 |
| R-HSA-195721 | Signaling by WNT | 0.876840 | 0.057 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.895723 | 0.048 |
| R-HSA-1266738 | Developmental Biology | 0.907145 | 0.042 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.911143 | 0.040 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.911399 | 0.040 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.912321 | 0.040 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.933777 | 0.030 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.936808 | 0.028 |
| R-HSA-168256 | Immune System | 0.964094 | 0.016 |
| R-HSA-211859 | Biological oxidations | 0.972907 | 0.012 |
| R-HSA-556833 | Metabolism of lipids | 0.973150 | 0.012 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.976809 | 0.010 |
| R-HSA-9679506 | SARS-CoV Infections | 0.978174 | 0.010 |
| R-HSA-168249 | Innate Immune System | 0.979668 | 0.009 |
| R-HSA-449147 | Signaling by Interleukins | 0.986419 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 0.990631 | 0.004 |
| R-HSA-109582 | Hemostasis | 0.995414 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 0.996374 | 0.002 |
| R-HSA-1643685 | Disease | 0.997458 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.999197 | 0.000 |
| R-HSA-9824446 | Viral Infection Pathways | 0.999576 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999805 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999993 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999995 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.774 | 0.313 | 1 | 0.838 |
JNK2 |
0.773 | 0.396 | 1 | 0.855 |
JNK3 |
0.766 | 0.372 | 1 | 0.865 |
COT |
0.766 | 0.119 | 2 | 0.340 |
DYRK4 |
0.765 | 0.384 | 1 | 0.847 |
CDK1 |
0.763 | 0.326 | 1 | 0.846 |
CDK8 |
0.762 | 0.288 | 1 | 0.853 |
KIS |
0.761 | 0.236 | 1 | 0.872 |
P38B |
0.761 | 0.354 | 1 | 0.848 |
CDK19 |
0.760 | 0.292 | 1 | 0.844 |
DYRK2 |
0.758 | 0.309 | 1 | 0.861 |
MTOR |
0.757 | 0.200 | 1 | 0.730 |
P38G |
0.756 | 0.326 | 1 | 0.809 |
ERK1 |
0.756 | 0.311 | 1 | 0.854 |
CDK18 |
0.756 | 0.294 | 1 | 0.841 |
CDK3 |
0.756 | 0.291 | 1 | 0.823 |
P38D |
0.755 | 0.344 | 1 | 0.835 |
FAM20C |
0.755 | 0.017 | 2 | 0.273 |
NLK |
0.754 | 0.213 | 1 | 0.861 |
ERK5 |
0.753 | 0.152 | 1 | 0.795 |
CDK5 |
0.753 | 0.266 | 1 | 0.872 |
JNK1 |
0.753 | 0.337 | 1 | 0.837 |
P38A |
0.753 | 0.330 | 1 | 0.871 |
HIPK4 |
0.752 | 0.159 | 1 | 0.829 |
CDK7 |
0.752 | 0.265 | 1 | 0.869 |
CLK2 |
0.751 | 0.275 | -3 | 0.639 |
CDK17 |
0.750 | 0.288 | 1 | 0.811 |
GRK1 |
0.750 | 0.065 | -2 | 0.747 |
CDK13 |
0.749 | 0.258 | 1 | 0.865 |
CDC7 |
0.749 | -0.015 | 1 | 0.650 |
CAMK2G |
0.749 | 0.017 | 2 | 0.303 |
ICK |
0.748 | 0.169 | -3 | 0.745 |
ERK2 |
0.747 | 0.284 | 1 | 0.864 |
MOS |
0.747 | 0.049 | 1 | 0.691 |
HIPK2 |
0.747 | 0.260 | 1 | 0.839 |
CDK12 |
0.746 | 0.264 | 1 | 0.857 |
IKKB |
0.746 | 0.011 | -2 | 0.713 |
RAF1 |
0.745 | 0.075 | 1 | 0.690 |
CDKL1 |
0.744 | 0.079 | -3 | 0.716 |
CDK2 |
0.744 | 0.226 | 1 | 0.842 |
DSTYK |
0.744 | 0.035 | 2 | 0.353 |
PIM3 |
0.743 | 0.011 | -3 | 0.731 |
NDR2 |
0.742 | -0.003 | -3 | 0.724 |
CDK9 |
0.742 | 0.252 | 1 | 0.869 |
SRPK1 |
0.742 | 0.112 | -3 | 0.664 |
TBK1 |
0.742 | -0.029 | 1 | 0.631 |
PRPK |
0.741 | -0.060 | -1 | 0.769 |
IKKE |
0.740 | -0.012 | 1 | 0.631 |
CDKL5 |
0.740 | 0.074 | -3 | 0.704 |
IKKA |
0.740 | 0.009 | -2 | 0.699 |
CDK14 |
0.739 | 0.270 | 1 | 0.863 |
CDK16 |
0.739 | 0.270 | 1 | 0.821 |
ATR |
0.739 | -0.000 | 1 | 0.690 |
SKMLCK |
0.738 | 0.059 | -2 | 0.792 |
CHAK2 |
0.738 | 0.002 | -1 | 0.831 |
PDHK4 |
0.738 | -0.087 | 1 | 0.716 |
CAMK1B |
0.737 | 0.004 | -3 | 0.770 |
CDK10 |
0.737 | 0.256 | 1 | 0.861 |
HUNK |
0.737 | 0.037 | 2 | 0.332 |
GCN2 |
0.737 | -0.141 | 2 | 0.258 |
HIPK1 |
0.737 | 0.219 | 1 | 0.863 |
DYRK1A |
0.735 | 0.204 | 1 | 0.874 |
ULK2 |
0.735 | -0.151 | 2 | 0.226 |
GRK6 |
0.735 | 0.024 | 1 | 0.642 |
CAMK2B |
0.734 | 0.029 | 2 | 0.322 |
CAMK2A |
0.734 | 0.046 | 2 | 0.347 |
DYRK1B |
0.733 | 0.246 | 1 | 0.864 |
GSK3A |
0.733 | 0.110 | 4 | 0.479 |
PIM1 |
0.733 | 0.020 | -3 | 0.669 |
MST4 |
0.732 | -0.030 | 2 | 0.277 |
MLK1 |
0.732 | -0.084 | 2 | 0.271 |
GRK5 |
0.732 | -0.073 | -3 | 0.826 |
RIPK3 |
0.732 | -0.020 | 3 | 0.691 |
CLK4 |
0.732 | 0.158 | -3 | 0.655 |
ULK1 |
0.732 | -0.118 | -3 | 0.762 |
DNAPK |
0.732 | 0.080 | 1 | 0.657 |
BMPR2 |
0.732 | -0.097 | -2 | 0.827 |
RSK2 |
0.731 | 0.002 | -3 | 0.664 |
MAK |
0.731 | 0.248 | -2 | 0.857 |
PRKD1 |
0.731 | -0.032 | -3 | 0.706 |
CAMK2D |
0.731 | -0.030 | -3 | 0.730 |
ERK7 |
0.730 | 0.062 | 2 | 0.170 |
LATS1 |
0.729 | 0.051 | -3 | 0.741 |
MLK3 |
0.729 | -0.044 | 2 | 0.231 |
NEK6 |
0.729 | -0.092 | -2 | 0.761 |
ATM |
0.729 | 0.013 | 1 | 0.642 |
WNK1 |
0.728 | -0.036 | -2 | 0.830 |
PKN3 |
0.728 | -0.060 | -3 | 0.714 |
DYRK3 |
0.728 | 0.202 | 1 | 0.849 |
NDR1 |
0.728 | -0.049 | -3 | 0.714 |
CLK1 |
0.728 | 0.156 | -3 | 0.627 |
LATS2 |
0.728 | -0.031 | -5 | 0.734 |
PKCD |
0.727 | -0.043 | 2 | 0.236 |
PRP4 |
0.727 | 0.156 | -3 | 0.721 |
PDHK1 |
0.727 | -0.170 | 1 | 0.702 |
PLK3 |
0.727 | 0.032 | 2 | 0.332 |
PKN2 |
0.727 | -0.025 | -3 | 0.729 |
MARK4 |
0.727 | -0.042 | 4 | 0.663 |
NEK7 |
0.726 | -0.130 | -3 | 0.793 |
CAMLCK |
0.726 | -0.020 | -2 | 0.801 |
MASTL |
0.726 | -0.114 | -2 | 0.789 |
PRKD2 |
0.726 | -0.018 | -3 | 0.638 |
PAK1 |
0.726 | -0.021 | -2 | 0.761 |
P90RSK |
0.726 | -0.023 | -3 | 0.666 |
GRK7 |
0.726 | 0.037 | 1 | 0.611 |
NIK |
0.726 | -0.079 | -3 | 0.787 |
MLK2 |
0.726 | -0.087 | 2 | 0.251 |
DLK |
0.726 | -0.002 | 1 | 0.641 |
HIPK3 |
0.725 | 0.185 | 1 | 0.862 |
NUAK2 |
0.725 | -0.016 | -3 | 0.727 |
BMPR1B |
0.725 | 0.073 | 1 | 0.587 |
SRPK2 |
0.724 | 0.056 | -3 | 0.575 |
CDK6 |
0.724 | 0.239 | 1 | 0.858 |
GRK4 |
0.724 | -0.069 | -2 | 0.745 |
PLK1 |
0.724 | -0.024 | -2 | 0.740 |
BCKDK |
0.724 | -0.115 | -1 | 0.719 |
AURC |
0.723 | 0.008 | -2 | 0.629 |
TTBK2 |
0.723 | -0.132 | 2 | 0.206 |
PLK4 |
0.723 | -0.064 | 2 | 0.187 |
RSK4 |
0.723 | 0.013 | -3 | 0.624 |
PKACG |
0.722 | -0.028 | -2 | 0.717 |
P70S6KB |
0.722 | -0.034 | -3 | 0.682 |
GSK3B |
0.721 | 0.047 | 4 | 0.464 |
MSK1 |
0.721 | 0.031 | -3 | 0.636 |
DAPK2 |
0.721 | -0.050 | -3 | 0.774 |
RIPK1 |
0.721 | -0.081 | 1 | 0.651 |
TGFBR1 |
0.721 | 0.009 | -2 | 0.698 |
PKCG |
0.720 | -0.042 | 2 | 0.233 |
MLK4 |
0.720 | -0.081 | 2 | 0.224 |
NIM1 |
0.720 | -0.096 | 3 | 0.704 |
CDK4 |
0.720 | 0.242 | 1 | 0.850 |
PKCA |
0.720 | -0.051 | 2 | 0.209 |
RSK3 |
0.719 | -0.043 | -3 | 0.654 |
MAPKAPK2 |
0.719 | -0.009 | -3 | 0.598 |
PKCB |
0.719 | -0.052 | 2 | 0.223 |
PKR |
0.719 | -0.046 | 1 | 0.687 |
YSK4 |
0.718 | -0.030 | 1 | 0.626 |
TSSK2 |
0.718 | -0.063 | -5 | 0.757 |
DRAK1 |
0.718 | 0.089 | 1 | 0.583 |
SRPK3 |
0.718 | 0.036 | -3 | 0.640 |
NEK9 |
0.717 | -0.167 | 2 | 0.246 |
MNK2 |
0.717 | -0.030 | -2 | 0.753 |
PAK3 |
0.717 | -0.073 | -2 | 0.760 |
ANKRD3 |
0.717 | -0.147 | 1 | 0.694 |
WNK3 |
0.717 | -0.190 | 1 | 0.667 |
SMG1 |
0.717 | -0.023 | 1 | 0.656 |
TGFBR2 |
0.716 | -0.136 | -2 | 0.702 |
MSK2 |
0.716 | -0.027 | -3 | 0.637 |
MEK1 |
0.716 | -0.050 | 2 | 0.305 |
MNK1 |
0.716 | -0.018 | -2 | 0.769 |
PKACB |
0.716 | 0.010 | -2 | 0.641 |
AMPKA1 |
0.716 | -0.098 | -3 | 0.735 |
PASK |
0.715 | 0.126 | -3 | 0.758 |
PRKX |
0.715 | 0.028 | -3 | 0.546 |
ALK4 |
0.714 | -0.045 | -2 | 0.727 |
MAPKAPK3 |
0.714 | -0.067 | -3 | 0.643 |
MARK3 |
0.714 | 0.002 | 4 | 0.607 |
PKCZ |
0.714 | -0.067 | 2 | 0.225 |
TSSK1 |
0.714 | -0.070 | -3 | 0.756 |
MEKK3 |
0.713 | -0.002 | 1 | 0.643 |
IRE1 |
0.713 | -0.146 | 1 | 0.642 |
VRK2 |
0.712 | -0.122 | 1 | 0.728 |
ALK2 |
0.711 | 0.014 | -2 | 0.702 |
PLK2 |
0.711 | 0.032 | -3 | 0.738 |
NEK2 |
0.711 | -0.112 | 2 | 0.231 |
ACVR2B |
0.711 | -0.005 | -2 | 0.714 |
QSK |
0.711 | -0.050 | 4 | 0.634 |
PAK6 |
0.711 | -0.043 | -2 | 0.679 |
TLK2 |
0.711 | -0.089 | 1 | 0.655 |
AMPKA2 |
0.711 | -0.085 | -3 | 0.694 |
CHAK1 |
0.710 | -0.130 | 2 | 0.209 |
AURB |
0.710 | -0.025 | -2 | 0.621 |
MYLK4 |
0.710 | 0.003 | -2 | 0.719 |
PAK2 |
0.710 | -0.078 | -2 | 0.746 |
AURA |
0.710 | -0.013 | -2 | 0.577 |
MPSK1 |
0.709 | 0.035 | 1 | 0.669 |
PKCH |
0.709 | -0.095 | 2 | 0.209 |
BMPR1A |
0.709 | 0.043 | 1 | 0.563 |
MOK |
0.709 | 0.172 | 1 | 0.827 |
PINK1 |
0.709 | -0.018 | 1 | 0.772 |
BRSK1 |
0.709 | -0.078 | -3 | 0.664 |
CK2A2 |
0.708 | 0.025 | 1 | 0.497 |
SGK3 |
0.707 | -0.031 | -3 | 0.641 |
CAMK4 |
0.707 | -0.105 | -3 | 0.693 |
PRKD3 |
0.707 | -0.057 | -3 | 0.627 |
MST3 |
0.707 | -0.013 | 2 | 0.302 |
MARK2 |
0.707 | -0.054 | 4 | 0.582 |
ACVR2A |
0.707 | -0.047 | -2 | 0.708 |
BRAF |
0.707 | -0.066 | -4 | 0.812 |
IRE2 |
0.707 | -0.158 | 2 | 0.194 |
CK1E |
0.706 | -0.012 | -3 | 0.571 |
AKT2 |
0.706 | -0.008 | -3 | 0.576 |
GAK |
0.706 | 0.115 | 1 | 0.697 |
QIK |
0.705 | -0.116 | -3 | 0.726 |
CAMK1G |
0.705 | -0.029 | -3 | 0.645 |
GRK2 |
0.705 | -0.045 | -2 | 0.634 |
YANK3 |
0.705 | -0.019 | 2 | 0.174 |
MEKK2 |
0.704 | -0.115 | 2 | 0.244 |
SIK |
0.703 | -0.082 | -3 | 0.633 |
MARK1 |
0.703 | -0.047 | 4 | 0.617 |
MELK |
0.703 | -0.125 | -3 | 0.675 |
DCAMKL2 |
0.703 | -0.049 | -3 | 0.679 |
NUAK1 |
0.703 | -0.102 | -3 | 0.659 |
PKG2 |
0.702 | -0.051 | -2 | 0.662 |
MEK5 |
0.702 | -0.153 | 2 | 0.271 |
SNRK |
0.701 | -0.171 | 2 | 0.201 |
BRSK2 |
0.701 | -0.116 | -3 | 0.687 |
DCAMKL1 |
0.701 | -0.056 | -3 | 0.649 |
TTBK1 |
0.701 | -0.130 | 2 | 0.187 |
MEKK1 |
0.701 | -0.161 | 1 | 0.655 |
TLK1 |
0.701 | -0.093 | -2 | 0.724 |
CK1G1 |
0.701 | -0.043 | -3 | 0.579 |
CK2A1 |
0.701 | 0.026 | 1 | 0.475 |
PIM2 |
0.700 | -0.038 | -3 | 0.632 |
SSTK |
0.700 | -0.069 | 4 | 0.601 |
CAMKK1 |
0.700 | -0.045 | -2 | 0.745 |
LKB1 |
0.700 | 0.002 | -3 | 0.747 |
ZAK |
0.699 | -0.151 | 1 | 0.601 |
STK33 |
0.699 | -0.060 | 2 | 0.212 |
NEK11 |
0.699 | -0.040 | 1 | 0.668 |
TAO3 |
0.699 | -0.061 | 1 | 0.655 |
GCK |
0.699 | 0.047 | 1 | 0.686 |
NEK5 |
0.699 | -0.112 | 1 | 0.677 |
IRAK4 |
0.699 | -0.138 | 1 | 0.645 |
PERK |
0.698 | -0.175 | -2 | 0.764 |
CK1D |
0.698 | -0.006 | -3 | 0.529 |
PHKG1 |
0.698 | -0.151 | -3 | 0.699 |
SMMLCK |
0.697 | -0.025 | -3 | 0.716 |
WNK4 |
0.697 | -0.128 | -2 | 0.814 |
PKCI |
0.696 | -0.077 | 2 | 0.214 |
TAK1 |
0.696 | 0.035 | 1 | 0.671 |
CHK1 |
0.696 | -0.105 | -3 | 0.682 |
PAK4 |
0.696 | -0.054 | -2 | 0.638 |
PKACA |
0.696 | -0.020 | -2 | 0.602 |
PKCT |
0.695 | -0.101 | 2 | 0.199 |
MST2 |
0.695 | -0.034 | 1 | 0.670 |
CK1A2 |
0.695 | -0.020 | -3 | 0.525 |
CAMKK2 |
0.695 | -0.062 | -2 | 0.756 |
PDK1 |
0.694 | -0.064 | 1 | 0.682 |
PKCE |
0.693 | -0.054 | 2 | 0.221 |
NEK8 |
0.692 | -0.141 | 2 | 0.252 |
HPK1 |
0.692 | 0.016 | 1 | 0.688 |
PAK5 |
0.692 | -0.067 | -2 | 0.640 |
HRI |
0.692 | -0.203 | -2 | 0.783 |
GRK3 |
0.691 | -0.052 | -2 | 0.572 |
MAPKAPK5 |
0.690 | -0.120 | -3 | 0.599 |
P70S6K |
0.690 | -0.075 | -3 | 0.589 |
MINK |
0.690 | -0.069 | 1 | 0.669 |
TNIK |
0.689 | -0.049 | 3 | 0.749 |
NEK4 |
0.689 | -0.111 | 1 | 0.665 |
SLK |
0.688 | -0.023 | -2 | 0.747 |
AKT1 |
0.688 | -0.052 | -3 | 0.583 |
MST1 |
0.688 | -0.035 | 1 | 0.657 |
MAP3K15 |
0.687 | -0.094 | 1 | 0.609 |
EEF2K |
0.687 | -0.085 | 3 | 0.732 |
CAMK1D |
0.687 | -0.054 | -3 | 0.548 |
PDHK3_TYR |
0.687 | 0.200 | 4 | 0.742 |
LRRK2 |
0.687 | -0.085 | 2 | 0.269 |
TAO2 |
0.686 | -0.130 | 2 | 0.259 |
MEKK6 |
0.685 | -0.110 | 1 | 0.639 |
SGK1 |
0.685 | -0.013 | -3 | 0.494 |
HGK |
0.685 | -0.103 | 3 | 0.751 |
HASPIN |
0.685 | 0.064 | -1 | 0.809 |
KHS2 |
0.684 | -0.014 | 1 | 0.700 |
LOK |
0.684 | -0.083 | -2 | 0.790 |
KHS1 |
0.684 | -0.035 | 1 | 0.686 |
PHKG2 |
0.683 | -0.143 | -3 | 0.673 |
IRAK1 |
0.683 | -0.212 | -1 | 0.699 |
BUB1 |
0.682 | -0.025 | -5 | 0.735 |
DAPK3 |
0.682 | -0.051 | -3 | 0.681 |
SBK |
0.682 | 0.009 | -3 | 0.452 |
VRK1 |
0.681 | -0.111 | 2 | 0.278 |
PDHK4_TYR |
0.681 | 0.196 | 2 | 0.356 |
ROCK2 |
0.680 | -0.028 | -3 | 0.659 |
MRCKB |
0.680 | -0.029 | -3 | 0.614 |
MRCKA |
0.680 | -0.030 | -3 | 0.624 |
AKT3 |
0.680 | -0.038 | -3 | 0.512 |
PBK |
0.680 | -0.025 | 1 | 0.648 |
DAPK1 |
0.679 | -0.036 | -3 | 0.671 |
NEK1 |
0.679 | -0.128 | 1 | 0.649 |
PKN1 |
0.679 | -0.090 | -3 | 0.602 |
MAP2K6_TYR |
0.678 | 0.178 | -1 | 0.798 |
MEK2 |
0.677 | -0.163 | 2 | 0.244 |
BMPR2_TYR |
0.675 | 0.106 | -1 | 0.800 |
ALPHAK3 |
0.675 | 0.003 | -1 | 0.700 |
CAMK1A |
0.674 | -0.061 | -3 | 0.529 |
YSK1 |
0.674 | -0.137 | 2 | 0.232 |
OSR1 |
0.673 | -0.081 | 2 | 0.249 |
CHK2 |
0.673 | -0.050 | -3 | 0.511 |
PDHK1_TYR |
0.673 | 0.099 | -1 | 0.805 |
DMPK1 |
0.672 | -0.001 | -3 | 0.640 |
MAP2K4_TYR |
0.671 | 0.029 | -1 | 0.796 |
RIPK2 |
0.671 | -0.182 | 1 | 0.583 |
TESK1_TYR |
0.671 | -0.034 | 3 | 0.780 |
BIKE |
0.670 | -0.000 | 1 | 0.621 |
MAP2K7_TYR |
0.670 | -0.037 | 2 | 0.305 |
YANK2 |
0.670 | -0.041 | 2 | 0.179 |
EPHA4 |
0.670 | 0.102 | 2 | 0.369 |
CK1A |
0.668 | -0.036 | -3 | 0.453 |
CRIK |
0.668 | -0.023 | -3 | 0.586 |
ASK1 |
0.667 | -0.100 | 1 | 0.594 |
EPHA6 |
0.667 | 0.029 | -1 | 0.774 |
LIMK2_TYR |
0.666 | -0.028 | -3 | 0.801 |
MYO3A |
0.666 | -0.103 | 1 | 0.670 |
PKMYT1_TYR |
0.665 | -0.080 | 3 | 0.766 |
TTK |
0.664 | -0.120 | -2 | 0.740 |
ROCK1 |
0.664 | -0.045 | -3 | 0.621 |
NEK3 |
0.663 | -0.176 | 1 | 0.626 |
EPHB4 |
0.663 | 0.031 | -1 | 0.739 |
MYO3B |
0.663 | -0.113 | 2 | 0.233 |
PKG1 |
0.662 | -0.076 | -2 | 0.604 |
PINK1_TYR |
0.661 | -0.142 | 1 | 0.674 |
AAK1 |
0.658 | 0.024 | 1 | 0.560 |
SRMS |
0.657 | 0.077 | 1 | 0.629 |
TXK |
0.655 | 0.065 | 1 | 0.595 |
TNK2 |
0.655 | -0.016 | 3 | 0.677 |
RET |
0.655 | -0.101 | 1 | 0.651 |
EPHB1 |
0.654 | 0.017 | 1 | 0.628 |
DDR1 |
0.654 | -0.062 | 4 | 0.629 |
TAO1 |
0.654 | -0.148 | 1 | 0.605 |
CSF1R |
0.654 | -0.045 | 3 | 0.706 |
EPHB2 |
0.653 | 0.025 | -1 | 0.709 |
FGFR2 |
0.653 | -0.022 | 3 | 0.733 |
INSRR |
0.653 | -0.054 | 3 | 0.689 |
LIMK1_TYR |
0.653 | -0.182 | 2 | 0.256 |
ITK |
0.653 | 0.060 | -1 | 0.681 |
MST1R |
0.652 | -0.111 | 3 | 0.722 |
EPHB3 |
0.652 | 0.007 | -1 | 0.717 |
STLK3 |
0.652 | -0.150 | 1 | 0.583 |
YES1 |
0.652 | -0.032 | -1 | 0.723 |
EPHA7 |
0.652 | 0.014 | 2 | 0.335 |
TEK |
0.651 | -0.001 | 3 | 0.682 |
JAK2 |
0.651 | -0.158 | 1 | 0.655 |
EPHA3 |
0.651 | -0.011 | 2 | 0.325 |
TYRO3 |
0.651 | -0.131 | 3 | 0.715 |
JAK3 |
0.650 | -0.068 | 1 | 0.614 |
PTK2 |
0.650 | 0.076 | -1 | 0.716 |
TYK2 |
0.650 | -0.228 | 1 | 0.655 |
KIT |
0.649 | -0.011 | 3 | 0.716 |
ROS1 |
0.649 | -0.180 | 3 | 0.700 |
FGFR3 |
0.648 | 0.007 | 3 | 0.712 |
BMX |
0.648 | 0.048 | -1 | 0.610 |
EPHA5 |
0.648 | 0.042 | 2 | 0.360 |
FYN |
0.648 | 0.048 | -1 | 0.684 |
FER |
0.647 | -0.083 | 1 | 0.656 |
BLK |
0.647 | 0.010 | -1 | 0.727 |
FGR |
0.647 | -0.098 | 1 | 0.646 |
ABL2 |
0.645 | -0.080 | -1 | 0.697 |
HCK |
0.645 | -0.079 | -1 | 0.708 |
FGFR1 |
0.644 | -0.097 | 3 | 0.698 |
LCK |
0.644 | -0.039 | -1 | 0.709 |
TNK1 |
0.644 | -0.100 | 3 | 0.700 |
CK1G3 |
0.644 | -0.044 | -3 | 0.414 |
NEK10_TYR |
0.643 | -0.119 | 1 | 0.576 |
FLT1 |
0.643 | -0.007 | -1 | 0.748 |
KDR |
0.642 | -0.089 | 3 | 0.679 |
MERTK |
0.642 | -0.067 | 3 | 0.694 |
FGFR4 |
0.641 | -0.001 | -1 | 0.663 |
DDR2 |
0.641 | 0.011 | 3 | 0.679 |
EPHA8 |
0.641 | -0.000 | -1 | 0.710 |
ABL1 |
0.641 | -0.101 | -1 | 0.683 |
FLT3 |
0.641 | -0.118 | 3 | 0.699 |
AXL |
0.641 | -0.108 | 3 | 0.704 |
MET |
0.639 | -0.069 | 3 | 0.692 |
ERBB2 |
0.638 | -0.090 | 1 | 0.587 |
NTRK1 |
0.638 | -0.120 | -1 | 0.698 |
CSK |
0.638 | -0.025 | 2 | 0.321 |
FLT4 |
0.638 | -0.081 | 3 | 0.698 |
EPHA2 |
0.638 | 0.030 | -1 | 0.684 |
JAK1 |
0.638 | -0.147 | 1 | 0.616 |
SYK |
0.637 | 0.037 | -1 | 0.692 |
EGFR |
0.637 | -0.036 | 1 | 0.491 |
TEC |
0.636 | -0.052 | -1 | 0.616 |
PDGFRB |
0.636 | -0.229 | 3 | 0.716 |
FRK |
0.636 | -0.052 | -1 | 0.730 |
SRC |
0.636 | -0.023 | -1 | 0.677 |
LYN |
0.635 | -0.043 | 3 | 0.648 |
TNNI3K_TYR |
0.635 | -0.171 | 1 | 0.645 |
BTK |
0.634 | -0.111 | -1 | 0.646 |
PTK2B |
0.634 | -0.028 | -1 | 0.640 |
CK1G2 |
0.633 | -0.029 | -3 | 0.498 |
WEE1_TYR |
0.633 | -0.124 | -1 | 0.661 |
MATK |
0.632 | -0.052 | -1 | 0.639 |
LTK |
0.632 | -0.165 | 3 | 0.677 |
INSR |
0.632 | -0.142 | 3 | 0.670 |
ERBB4 |
0.632 | -0.002 | 1 | 0.513 |
EPHA1 |
0.631 | -0.114 | 3 | 0.677 |
PDGFRA |
0.630 | -0.248 | 3 | 0.715 |
PTK6 |
0.629 | -0.211 | -1 | 0.598 |
ALK |
0.629 | -0.194 | 3 | 0.648 |
NTRK3 |
0.628 | -0.124 | -1 | 0.649 |
IGF1R |
0.625 | -0.093 | 3 | 0.624 |
NTRK2 |
0.624 | -0.213 | 3 | 0.674 |
ZAP70 |
0.612 | -0.007 | -1 | 0.617 |
FES |
0.611 | -0.084 | -1 | 0.575 |
MUSK |
0.605 | -0.181 | 1 | 0.495 |