Motif 371 (n=119)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6H8Y1 | BDP1 | S2449 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| O00515 | LAD1 | S121 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O15155 | BET1 | S48 | ochoa | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | Required for vesicular transport from the ER to the Golgi complex (PubMed:34779586). Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250|UniProtKB:Q62896, ECO:0000269|PubMed:34779586}. |
| O15438 | ABCC3 | S884 | ochoa | ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066, ECO:0000305|PubMed:35307651}. |
| O43399 | TPD52L2 | S94 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43847 | NRDC | S106 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60447 | EVI5 | S763 | ochoa | Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein) | Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}. |
| O75420 | GIGYF1 | S228 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O75554 | WBP4 | S323 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O75691 | UTP20 | S1732 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O95235 | KIF20A | S109 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95613 | PCNT | S2477 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95674 | CDS2 | S35 | ochoa | Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) | Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}. |
| P00558 | PGK1 | S364 | ochoa | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P07451 | CA3 | S48 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P07949 | RET | S835 | ochoa | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P17302 | GJA1 | S328 | ochoa|psp | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
| P24821 | TNC | S84 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P26232 | CTNNA2 | S320 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P28290 | ITPRID2 | S650 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P35221 | CTNNA1 | S322 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35610 | SOAT1 | S84 | ochoa | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}. |
| P38936 | CDKN1A | S123 | psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P46821 | MAP1B | S25 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S965 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P51116 | FXR2 | S637 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P57060 | RWDD2B | S171 | ochoa | RWD domain-containing protein 2B | None |
| P78332 | RBM6 | S353 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P85299 | PRR5 | S282 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| Q02952 | AKAP12 | S1618 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S613 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04637 | EIF4G1 | S1028 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q12830 | BPTF | S761 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12923 | PTPN13 | S215 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13263 | TRIM28 | S624 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13428 | TCOF1 | S1199 | ochoa|psp | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13625 | TP53BP2 | S737 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14596 | NBR1 | S656 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14676 | MDC1 | S598 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14684 | RRP1B | S503 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q15424 | SAFB | S21 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15477 | SKIC2 | S243 | ochoa | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}. |
| Q27J81 | INF2 | S1192 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q32MZ4 | LRRFIP1 | S766 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q58WW2 | DCAF6 | S649 | ochoa | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q5JSH3 | WDR44 | S197 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5QJE6 | DNTTIP2 | S474 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5S007 | LRRK2 | S933 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5TZA2 | CROCC | S462 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q6J9G0 | STYK1 | S91 | ochoa | Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1) | Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}. |
| Q6P996 | PDXDC1 | S748 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6T4R5 | NHS | S991 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6WCQ1 | MPRIP | S326 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZN16 | MAP3K15 | S68 | ochoa | Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) | Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases (PubMed:20362554, PubMed:26732173). May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (PubMed:20362554). Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade (PubMed:26732173). {ECO:0000269|PubMed:20362554, ECO:0000269|PubMed:26732173}. |
| Q6ZTU2 | EP400P1 | S152 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q6ZVL6 | KIAA1549L | S1681 | ochoa | UPF0606 protein KIAA1549L | None |
| Q6ZW31 | SYDE1 | S64 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q7RTP6 | MICAL3 | S1300 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z3D4 | LYSMD3 | S53 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 3 | Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}. |
| Q7Z6J6 | FRMD5 | S349 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q7Z6J6 | FRMD5 | S396 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q7Z739 | YTHDF3 | S383 | ochoa | YTH domain-containing family protein 3 (DF3) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}. |
| Q86XP3 | DDX42 | S43 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8IV53 | DENND1C | S580 | ochoa | DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8N344 | MIER2 | S107 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8N8S7 | ENAH | S486 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8NCE2 | MTMR14 | S624 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8TC90 | CCER1 | S230 | ochoa | Coiled-coil domain-containing glutamate-rich protein 1 | Regulator of histone epigenetic modifications and chromatin compaction into the sperm head, required for histone-to-protamine (HTP) transition. HTP is a key event in which somatic histones are first replaced by testis-specific histone variants, then transition proteins (TNPs) are incorporated into the spermatid nucleus, and finally protamines (PRMs) replace the TNPs to promote chromatin condensation. {ECO:0000250|UniProtKB:Q9CQL2}. |
| Q8TE68 | EPS8L1 | S237 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8WU90 | ZC3H15 | S326 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q92536 | SLC7A6 | S20 | ochoa | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}. |
| Q92945 | KHSRP | S129 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q93074 | MED12 | S555 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q969V6 | MRTFA | S112 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96CX2 | KCTD12 | S183 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96GS4 | BORCS6 | S166 | ochoa | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}. |
| Q96J84 | KIRREL1 | S573 | psp | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}. |
| Q96KQ4 | PPP1R13B | S710 | ochoa | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}. |
| Q96L91 | EP400 | S163 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96MG7 | NSMCE3 | S49 | ochoa | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}. |
| Q96N67 | DOCK7 | S180 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96RY5 | CRAMP1 | S777 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q96TA1 | NIBAN2 | S425 | ochoa | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}. |
| Q99590 | SCAF11 | S473 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BSJ6 | PIMREG | S91 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BSJ6 | PIMREG | S195 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BX66 | SORBS1 | S115 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BZL4 | PPP1R12C | S325 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9BZQ8 | NIBAN1 | S639 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
| Q9H0X9 | OSBPL5 | S325 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H7E2 | TDRD3 | S487 | ochoa | Tudor domain-containing protein 3 | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}. |
| Q9H8M2 | BRD9 | S43 | ochoa | Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) | Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}. |
| Q9NW64 | RBM22 | S142 | ochoa | Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:22246180, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154}. |
| Q9NWQ4 | GPATCH2L | S86 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NWV8 | BABAM1 | S47 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NX95 | SYBU | S71 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9NZ71 | RTEL1 | S303 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
| Q9NZQ3 | NCKIPSD | S120 | ochoa | NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) | Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. |
| Q9P0J7 | KCMF1 | S212 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P2J5 | LARS1 | S394 | ochoa | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}. |
| Q9UEY8 | ADD3 | S414 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHV7 | MED13 | S481 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9ULT8 | HECTD1 | S1718 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UMS6 | SYNPO2 | S204 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UNY4 | TTF2 | S233 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPU9 | SAMD4A | S166 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9UQB3 | CTNND2 | S398 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9UQC2 | GAB2 | S208 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9UQC2 | GAB2 | S425 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y2H5 | PLEKHA6 | S426 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2K5 | R3HDM2 | S853 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y3S1 | WNK2 | S1844 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9C0C2 | TNKS1BP1 | S804 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| P00441 | SOD1 | S106 | Sugiyama | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P27797 | CALR | S78 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| Q9BX68 | HINT2 | S57 | Sugiyama | Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718, ECO:0000269|PubMed:31990367}. |
| Q92499 | DDX1 | S541 | Sugiyama | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q9BYT3 | STK33 | S468 | Sugiyama | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9Y5K5 | UCHL5 | S131 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) | Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.000018 | 4.738 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.000018 | 4.738 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.000233 | 3.632 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.000717 | 3.145 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.000623 | 3.206 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.001145 | 2.941 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.002014 | 2.696 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.001982 | 2.703 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.001470 | 2.833 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.002070 | 2.684 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.002377 | 2.624 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.003114 | 2.507 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.004436 | 2.353 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.005406 | 2.267 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.006822 | 2.166 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.006607 | 2.180 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.007302 | 2.137 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.008671 | 2.062 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.008671 | 2.062 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.008671 | 2.062 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.009669 | 2.015 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.011601 | 1.936 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.011601 | 1.936 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.015377 | 1.813 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.017774 | 1.750 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.024112 | 1.618 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 0.024112 | 1.618 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 0.024112 | 1.618 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.019920 | 1.701 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.020666 | 1.685 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.019920 | 1.701 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.023687 | 1.625 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.022198 | 1.654 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.020749 | 1.683 |
| R-HSA-429947 | Deadenylation of mRNA | 0.025217 | 1.598 |
| R-HSA-525793 | Myogenesis | 0.028392 | 1.547 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.026738 | 1.573 |
| R-HSA-9830364 | Formation of the nephric duct | 0.026785 | 1.572 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.030037 | 1.522 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.033672 | 1.473 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.035191 | 1.454 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.040659 | 1.391 |
| R-HSA-191650 | Regulation of gap junction activity | 0.047647 | 1.322 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.063024 | 1.200 |
| R-HSA-9645135 | STAT5 Activation | 0.070619 | 1.151 |
| R-HSA-196025 | Formation of annular gap junctions | 0.085627 | 1.067 |
| R-HSA-190873 | Gap junction degradation | 0.093041 | 1.031 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.122104 | 0.913 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.122104 | 0.913 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.129224 | 0.889 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.129224 | 0.889 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.150242 | 0.823 |
| R-HSA-8853659 | RET signaling | 0.048410 | 1.315 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.163974 | 0.785 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.223091 | 0.652 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.248015 | 0.606 |
| R-HSA-72172 | mRNA Splicing | 0.275009 | 0.561 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.250976 | 0.600 |
| R-HSA-9646399 | Aggrephagy | 0.318126 | 0.497 |
| R-HSA-373753 | Nephrin family interactions | 0.184159 | 0.735 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.315412 | 0.501 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.315412 | 0.501 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.197347 | 0.705 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.203861 | 0.691 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.315412 | 0.501 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.254121 | 0.595 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.295508 | 0.529 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.070619 | 1.151 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.170757 | 0.768 |
| R-HSA-190828 | Gap junction trafficking | 0.345387 | 0.462 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.055367 | 1.257 |
| R-HSA-174577 | Activation of C3 and C5 | 0.055367 | 1.257 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.203861 | 0.691 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.241860 | 0.616 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.295508 | 0.529 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.103861 | 0.984 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.345387 | 0.462 |
| R-HSA-190861 | Gap junction assembly | 0.283922 | 0.547 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.216569 | 0.664 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.129224 | 0.889 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.210323 | 0.677 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.278058 | 0.556 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.295508 | 0.529 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.124947 | 0.903 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.170757 | 0.768 |
| R-HSA-69236 | G1 Phase | 0.345387 | 0.462 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.345387 | 0.462 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.334615 | 0.475 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.100395 | 0.998 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.100395 | 0.998 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.060937 | 1.215 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.177485 | 0.751 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.170757 | 0.768 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.177485 | 0.751 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.229398 | 0.639 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.254121 | 0.595 |
| R-HSA-9664873 | Pexophagy | 0.100395 | 0.998 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.076767 | 1.115 |
| R-HSA-9663891 | Selective autophagy | 0.187068 | 0.728 |
| R-HSA-9843745 | Adipogenesis | 0.336201 | 0.473 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.096233 | 1.017 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.138603 | 0.858 |
| R-HSA-73886 | Chromosome Maintenance | 0.300477 | 0.522 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.163570 | 0.786 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.047647 | 1.322 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.114926 | 0.940 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.129224 | 0.889 |
| R-HSA-9612973 | Autophagy | 0.169486 | 0.771 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.283922 | 0.547 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.283922 | 0.547 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.063024 | 1.200 |
| R-HSA-1483148 | Synthesis of PG | 0.157136 | 0.804 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.266186 | 0.575 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.329163 | 0.483 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.283922 | 0.547 |
| R-HSA-1632852 | Macroautophagy | 0.138718 | 0.858 |
| R-HSA-9607240 | FLT3 Signaling | 0.323667 | 0.490 |
| R-HSA-114608 | Platelet degranulation | 0.321368 | 0.493 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.101750 | 0.992 |
| R-HSA-8953854 | Metabolism of RNA | 0.262432 | 0.581 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.144154 | 0.841 |
| R-HSA-8875878 | MET promotes cell motility | 0.306909 | 0.513 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.272146 | 0.565 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.210323 | 0.677 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.241860 | 0.616 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.248015 | 0.606 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.254121 | 0.595 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.093618 | 1.029 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.342108 | 0.466 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.144154 | 0.841 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.058778 | 1.231 |
| R-HSA-1640170 | Cell Cycle | 0.140791 | 0.851 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.203861 | 0.691 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.223091 | 0.652 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.122104 | 0.913 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.146947 | 0.833 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.163928 | 0.785 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.122104 | 0.913 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.235654 | 0.628 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.340023 | 0.468 |
| R-HSA-9629569 | Protein hydroxylation | 0.184159 | 0.735 |
| R-HSA-210991 | Basigin interactions | 0.190780 | 0.719 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.223091 | 0.652 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.223091 | 0.652 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.248015 | 0.606 |
| R-HSA-381042 | PERK regulates gene expression | 0.289738 | 0.538 |
| R-HSA-2559583 | Cellular Senescence | 0.220914 | 0.656 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.318126 | 0.497 |
| R-HSA-69481 | G2/M Checkpoints | 0.321368 | 0.493 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.273481 | 0.563 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.087038 | 1.060 |
| R-HSA-9830369 | Kidney development | 0.124947 | 0.903 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.334615 | 0.475 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.278058 | 0.556 |
| R-HSA-9833110 | RSV-host interactions | 0.069575 | 1.158 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.271581 | 0.566 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.203861 | 0.691 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.203861 | 0.691 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.067571 | 1.170 |
| R-HSA-3000170 | Syndecan interactions | 0.210323 | 0.677 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.084238 | 1.074 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.219544 | 0.658 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.146947 | 0.833 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.055367 | 1.257 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.061393 | 1.212 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.272146 | 0.565 |
| R-HSA-202433 | Generation of second messenger molecules | 0.318126 | 0.497 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.044471 | 1.352 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.278058 | 0.556 |
| R-HSA-5693538 | Homology Directed Repair | 0.093618 | 1.029 |
| R-HSA-8964038 | LDL clearance | 0.203861 | 0.691 |
| R-HSA-168268 | Virus Assembly and Release | 0.150242 | 0.823 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.240265 | 0.619 |
| R-HSA-2262752 | Cellular responses to stress | 0.338398 | 0.471 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.340023 | 0.468 |
| R-HSA-1483255 | PI Metabolism | 0.065424 | 1.184 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.086332 | 1.064 |
| R-HSA-212436 | Generic Transcription Pathway | 0.297823 | 0.526 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.278058 | 0.556 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.098464 | 1.007 |
| R-HSA-165159 | MTOR signalling | 0.334615 | 0.475 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.049988 | 1.301 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.295508 | 0.529 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.340023 | 0.468 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.096233 | 1.017 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.312540 | 0.505 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.278518 | 0.555 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.119581 | 0.922 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.312540 | 0.505 |
| R-HSA-1483257 | Phospholipid metabolism | 0.115358 | 0.938 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.282490 | 0.549 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.294488 | 0.531 |
| R-HSA-194138 | Signaling by VEGF | 0.315412 | 0.501 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.177470 | 0.751 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.135018 | 0.870 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.294850 | 0.530 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.131353 | 0.882 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.149752 | 0.825 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.252455 | 0.598 |
| R-HSA-449147 | Signaling by Interleukins | 0.081804 | 1.087 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.252455 | 0.598 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.050874 | 1.294 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.184149 | 0.735 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.350708 | 0.455 |
| R-HSA-774815 | Nucleosome assembly | 0.350708 | 0.455 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.355986 | 0.449 |
| R-HSA-70263 | Gluconeogenesis | 0.366415 | 0.436 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.366415 | 0.436 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.371566 | 0.430 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.371566 | 0.430 |
| R-HSA-9766229 | Degradation of CDH1 | 0.371566 | 0.430 |
| R-HSA-109704 | PI3K Cascade | 0.376676 | 0.424 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.391760 | 0.407 |
| R-HSA-72649 | Translation initiation complex formation | 0.396707 | 0.402 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.397287 | 0.401 |
| R-HSA-9753281 | Paracetamol ADME | 0.401613 | 0.396 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.406481 | 0.391 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.408645 | 0.389 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.408645 | 0.389 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.411309 | 0.386 |
| R-HSA-112399 | IRS-mediated signalling | 0.411309 | 0.386 |
| R-HSA-1989781 | PPARA activates gene expression | 0.411469 | 0.386 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.416098 | 0.381 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.417096 | 0.380 |
| R-HSA-180786 | Extension of Telomeres | 0.420848 | 0.376 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.420848 | 0.376 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.424041 | 0.373 |
| R-HSA-379724 | tRNA Aminoacylation | 0.425560 | 0.371 |
| R-HSA-983189 | Kinesins | 0.425560 | 0.371 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.425560 | 0.371 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.430234 | 0.366 |
| R-HSA-109581 | Apoptosis | 0.431047 | 0.365 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.434871 | 0.362 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.434871 | 0.362 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.434871 | 0.362 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.439469 | 0.357 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.439469 | 0.357 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.439469 | 0.357 |
| R-HSA-8848021 | Signaling by PTK6 | 0.439469 | 0.357 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.439469 | 0.357 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.439785 | 0.357 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.444031 | 0.353 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.444031 | 0.353 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.448556 | 0.348 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.448556 | 0.348 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.453044 | 0.344 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.457496 | 0.340 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.457496 | 0.340 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.469144 | 0.329 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.470638 | 0.327 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.470638 | 0.327 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.470638 | 0.327 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.470638 | 0.327 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.473539 | 0.325 |
| R-HSA-3000178 | ECM proteoglycans | 0.474947 | 0.323 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.474947 | 0.323 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.479223 | 0.319 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.483463 | 0.316 |
| R-HSA-9749641 | Aspirin ADME | 0.483463 | 0.316 |
| R-HSA-380287 | Centrosome maturation | 0.491842 | 0.308 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.491842 | 0.308 |
| R-HSA-5689603 | UCH proteinases | 0.495980 | 0.305 |
| R-HSA-69275 | G2/M Transition | 0.498003 | 0.303 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.503144 | 0.298 |
| R-HSA-597592 | Post-translational protein modification | 0.503857 | 0.298 |
| R-HSA-216083 | Integrin cell surface interactions | 0.504157 | 0.297 |
| R-HSA-6806834 | Signaling by MET | 0.512202 | 0.291 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.512202 | 0.291 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.513323 | 0.290 |
| R-HSA-68877 | Mitotic Prometaphase | 0.515846 | 0.287 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.520118 | 0.284 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.527906 | 0.277 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.530277 | 0.275 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.531753 | 0.274 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.535569 | 0.271 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.535569 | 0.271 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.535569 | 0.271 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.539354 | 0.268 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.540606 | 0.267 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.540606 | 0.267 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.543109 | 0.265 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.546833 | 0.262 |
| R-HSA-5357801 | Programmed Cell Death | 0.547863 | 0.261 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.550527 | 0.259 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.554191 | 0.256 |
| R-HSA-74160 | Gene expression (Transcription) | 0.559660 | 0.252 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.561430 | 0.251 |
| R-HSA-391251 | Protein folding | 0.565006 | 0.248 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.565006 | 0.248 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.565006 | 0.248 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.566809 | 0.247 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.572071 | 0.243 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.582455 | 0.235 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.582455 | 0.235 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.582455 | 0.235 |
| R-HSA-8951664 | Neddylation | 0.585214 | 0.233 |
| R-HSA-157579 | Telomere Maintenance | 0.585861 | 0.232 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.585861 | 0.232 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.589239 | 0.230 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.590678 | 0.229 |
| R-HSA-3214847 | HATs acetylate histones | 0.592590 | 0.227 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.595913 | 0.225 |
| R-HSA-70171 | Glycolysis | 0.595913 | 0.225 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.595913 | 0.225 |
| R-HSA-73894 | DNA Repair | 0.599793 | 0.222 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.602480 | 0.220 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.608941 | 0.215 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.624641 | 0.204 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.624641 | 0.204 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.624641 | 0.204 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.624641 | 0.204 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.627705 | 0.202 |
| R-HSA-202403 | TCR signaling | 0.630744 | 0.200 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.630744 | 0.200 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.636749 | 0.196 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.636749 | 0.196 |
| R-HSA-68886 | M Phase | 0.639511 | 0.194 |
| R-HSA-4839726 | Chromatin organization | 0.645036 | 0.190 |
| R-HSA-166663 | Initial triggering of complement | 0.645575 | 0.190 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.645575 | 0.190 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.654188 | 0.184 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.654188 | 0.184 |
| R-HSA-5688426 | Deubiquitination | 0.656941 | 0.182 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.657012 | 0.182 |
| R-HSA-70326 | Glucose metabolism | 0.657012 | 0.182 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.668084 | 0.175 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.668084 | 0.175 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.673485 | 0.172 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.673485 | 0.172 |
| R-HSA-977606 | Regulation of Complement cascade | 0.678800 | 0.168 |
| R-HSA-422475 | Axon guidance | 0.679700 | 0.168 |
| R-HSA-69206 | G1/S Transition | 0.681425 | 0.167 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.692556 | 0.160 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.694234 | 0.158 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.701673 | 0.154 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.707054 | 0.151 |
| R-HSA-9664407 | Parasite infection | 0.722929 | 0.141 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.722929 | 0.141 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.722929 | 0.141 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.725196 | 0.140 |
| R-HSA-9675108 | Nervous system development | 0.726748 | 0.139 |
| R-HSA-166658 | Complement cascade | 0.736258 | 0.133 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.738416 | 0.132 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.740558 | 0.130 |
| R-HSA-1266738 | Developmental Biology | 0.742325 | 0.129 |
| R-HSA-69242 | S Phase | 0.742681 | 0.129 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.746877 | 0.127 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.751005 | 0.124 |
| R-HSA-1500931 | Cell-Cell communication | 0.760577 | 0.119 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.766860 | 0.115 |
| R-HSA-168256 | Immune System | 0.767889 | 0.115 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.774407 | 0.111 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.774407 | 0.111 |
| R-HSA-392499 | Metabolism of proteins | 0.784483 | 0.105 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.787036 | 0.104 |
| R-HSA-72306 | tRNA processing | 0.787036 | 0.104 |
| R-HSA-109582 | Hemostasis | 0.788876 | 0.103 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.792232 | 0.101 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.792232 | 0.101 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.793935 | 0.100 |
| R-HSA-199991 | Membrane Trafficking | 0.797689 | 0.098 |
| R-HSA-168255 | Influenza Infection | 0.802248 | 0.096 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.809673 | 0.092 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.816380 | 0.088 |
| R-HSA-983712 | Ion channel transport | 0.817887 | 0.087 |
| R-HSA-5617833 | Cilium Assembly | 0.819382 | 0.087 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.828099 | 0.082 |
| R-HSA-9609690 | HCMV Early Events | 0.828099 | 0.082 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.833676 | 0.079 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.836397 | 0.078 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.837741 | 0.077 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.843311 | 0.074 |
| R-HSA-913531 | Interferon Signaling | 0.843311 | 0.074 |
| R-HSA-397014 | Muscle contraction | 0.850593 | 0.070 |
| R-HSA-68882 | Mitotic Anaphase | 0.855445 | 0.068 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.856634 | 0.067 |
| R-HSA-418990 | Adherens junctions interactions | 0.857813 | 0.067 |
| R-HSA-9748784 | Drug ADME | 0.857813 | 0.067 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.869085 | 0.061 |
| R-HSA-72312 | rRNA processing | 0.873342 | 0.059 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.875418 | 0.058 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.878223 | 0.056 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.878470 | 0.056 |
| R-HSA-72766 | Translation | 0.883681 | 0.054 |
| R-HSA-162582 | Signal Transduction | 0.883772 | 0.054 |
| R-HSA-9609646 | HCMV Infection | 0.890858 | 0.050 |
| R-HSA-421270 | Cell-cell junction organization | 0.891758 | 0.050 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.896145 | 0.048 |
| R-HSA-9824446 | Viral Infection Pathways | 0.911562 | 0.040 |
| R-HSA-446728 | Cell junction organization | 0.913446 | 0.039 |
| R-HSA-9658195 | Leishmania infection | 0.915571 | 0.038 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.915571 | 0.038 |
| R-HSA-382551 | Transport of small molecules | 0.915631 | 0.038 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.916268 | 0.038 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.920990 | 0.036 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.925448 | 0.034 |
| R-HSA-556833 | Metabolism of lipids | 0.931591 | 0.031 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.938919 | 0.027 |
| R-HSA-1280218 | Adaptive Immune System | 0.939492 | 0.027 |
| R-HSA-8957322 | Metabolism of steroids | 0.940917 | 0.026 |
| R-HSA-1474244 | Extracellular matrix organization | 0.944257 | 0.025 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.951206 | 0.022 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.952011 | 0.021 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.966188 | 0.015 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.968108 | 0.014 |
| R-HSA-5663205 | Infectious disease | 0.973599 | 0.012 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.980370 | 0.009 |
| R-HSA-6798695 | Neutrophil degranulation | 0.980697 | 0.008 |
| R-HSA-168249 | Innate Immune System | 0.987619 | 0.005 |
| R-HSA-1643685 | Disease | 0.990560 | 0.004 |
| R-HSA-9679506 | SARS-CoV Infections | 0.991534 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995030 | 0.002 |
| R-HSA-1430728 | Metabolism | 0.999993 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.806 | 0.236 | 1 | 0.795 |
COT |
0.805 | 0.114 | 2 | 0.457 |
CLK2 |
0.802 | 0.286 | -3 | 0.744 |
SKMLCK |
0.800 | 0.221 | -2 | 0.863 |
CDC7 |
0.797 | 0.032 | 1 | 0.833 |
MOS |
0.795 | 0.094 | 1 | 0.854 |
PRKD1 |
0.795 | 0.094 | -3 | 0.823 |
FAM20C |
0.793 | 0.052 | 2 | 0.386 |
CAMK1B |
0.792 | 0.102 | -3 | 0.853 |
PIM3 |
0.792 | 0.068 | -3 | 0.829 |
DYRK4 |
0.790 | 0.208 | 1 | 0.641 |
RSK2 |
0.790 | 0.094 | -3 | 0.763 |
DYRK2 |
0.789 | 0.140 | 1 | 0.726 |
AURC |
0.789 | 0.152 | -2 | 0.730 |
HUNK |
0.789 | 0.102 | 2 | 0.451 |
HIPK4 |
0.788 | 0.065 | 1 | 0.809 |
PRKD2 |
0.788 | 0.078 | -3 | 0.770 |
IKKB |
0.788 | 0.010 | -2 | 0.678 |
RAF1 |
0.787 | 0.073 | 1 | 0.797 |
NDR2 |
0.787 | 0.020 | -3 | 0.834 |
PRPK |
0.787 | -0.055 | -1 | 0.832 |
SRPK1 |
0.787 | 0.096 | -3 | 0.739 |
ERK5 |
0.786 | 0.067 | 1 | 0.831 |
CAMK2G |
0.786 | -0.005 | 2 | 0.411 |
BMPR1B |
0.786 | 0.179 | 1 | 0.805 |
CAMLCK |
0.786 | 0.130 | -2 | 0.852 |
RIPK3 |
0.785 | 0.065 | 3 | 0.753 |
CLK4 |
0.785 | 0.174 | -3 | 0.762 |
GRK1 |
0.784 | 0.066 | -2 | 0.691 |
MSK1 |
0.784 | 0.158 | -3 | 0.743 |
DSTYK |
0.784 | 0.029 | 2 | 0.462 |
TSSK2 |
0.784 | 0.076 | -5 | 0.768 |
DAPK2 |
0.783 | 0.117 | -3 | 0.860 |
P90RSK |
0.783 | 0.055 | -3 | 0.764 |
MTOR |
0.782 | 0.020 | 1 | 0.739 |
PAK1 |
0.782 | 0.099 | -2 | 0.824 |
WNK1 |
0.781 | 0.034 | -2 | 0.839 |
CAMK2B |
0.781 | 0.063 | 2 | 0.429 |
NLK |
0.781 | -0.016 | 1 | 0.800 |
GRK6 |
0.781 | 0.079 | 1 | 0.802 |
CLK1 |
0.781 | 0.151 | -3 | 0.741 |
ATR |
0.781 | 0.004 | 1 | 0.800 |
NDR1 |
0.780 | 0.016 | -3 | 0.828 |
PDHK4 |
0.780 | -0.118 | 1 | 0.804 |
NUAK2 |
0.780 | 0.044 | -3 | 0.842 |
MYLK4 |
0.780 | 0.166 | -2 | 0.815 |
CAMK2A |
0.780 | 0.085 | 2 | 0.445 |
CDKL1 |
0.780 | 0.013 | -3 | 0.788 |
PIM1 |
0.779 | 0.063 | -3 | 0.775 |
MAPKAPK2 |
0.779 | 0.056 | -3 | 0.730 |
PKN3 |
0.778 | -0.014 | -3 | 0.828 |
CAMK2D |
0.778 | 0.006 | -3 | 0.839 |
BMPR2 |
0.778 | -0.066 | -2 | 0.804 |
GCN2 |
0.778 | -0.145 | 2 | 0.356 |
RSK3 |
0.778 | 0.041 | -3 | 0.759 |
PKN2 |
0.778 | 0.038 | -3 | 0.839 |
PKACB |
0.778 | 0.135 | -2 | 0.730 |
GRK5 |
0.777 | -0.040 | -3 | 0.857 |
CDKL5 |
0.777 | 0.013 | -3 | 0.781 |
IKKA |
0.777 | 0.005 | -2 | 0.653 |
PDHK1 |
0.777 | -0.132 | 1 | 0.784 |
ULK2 |
0.776 | -0.153 | 2 | 0.332 |
MAPKAPK3 |
0.776 | 0.023 | -3 | 0.778 |
AURB |
0.776 | 0.126 | -2 | 0.726 |
P70S6KB |
0.776 | 0.038 | -3 | 0.791 |
TGFBR1 |
0.776 | 0.091 | -2 | 0.755 |
NIK |
0.776 | -0.009 | -3 | 0.873 |
MARK4 |
0.776 | -0.012 | 4 | 0.744 |
RSK4 |
0.776 | 0.090 | -3 | 0.732 |
MSK2 |
0.776 | 0.081 | -3 | 0.731 |
TBK1 |
0.776 | -0.099 | 1 | 0.678 |
AURA |
0.775 | 0.144 | -2 | 0.713 |
KIS |
0.775 | 0.024 | 1 | 0.678 |
PAK3 |
0.775 | 0.057 | -2 | 0.821 |
IKKE |
0.775 | -0.063 | 1 | 0.676 |
PAK6 |
0.775 | 0.099 | -2 | 0.780 |
TSSK1 |
0.775 | 0.023 | -3 | 0.871 |
PKACG |
0.774 | 0.056 | -2 | 0.740 |
JNK2 |
0.774 | 0.119 | 1 | 0.613 |
MST4 |
0.773 | -0.031 | 2 | 0.394 |
TGFBR2 |
0.773 | -0.070 | -2 | 0.747 |
LATS2 |
0.772 | -0.022 | -5 | 0.645 |
PRKX |
0.772 | 0.126 | -3 | 0.683 |
ATM |
0.772 | 0.034 | 1 | 0.746 |
ICK |
0.772 | 0.007 | -3 | 0.827 |
MNK2 |
0.771 | 0.069 | -2 | 0.817 |
PKCD |
0.771 | -0.002 | 2 | 0.326 |
SRPK2 |
0.771 | 0.046 | -3 | 0.664 |
JNK3 |
0.771 | 0.101 | 1 | 0.643 |
RIPK1 |
0.770 | -0.028 | 1 | 0.771 |
LATS1 |
0.770 | 0.077 | -3 | 0.847 |
MNK1 |
0.770 | 0.077 | -2 | 0.815 |
CAMK4 |
0.770 | 0.013 | -3 | 0.823 |
AMPKA1 |
0.770 | -0.037 | -3 | 0.853 |
ALK4 |
0.769 | 0.035 | -2 | 0.785 |
CHAK2 |
0.769 | -0.055 | -1 | 0.859 |
ULK1 |
0.769 | -0.142 | -3 | 0.816 |
NEK6 |
0.769 | -0.116 | -2 | 0.780 |
GRK4 |
0.769 | -0.053 | -2 | 0.731 |
BMPR1A |
0.769 | 0.138 | 1 | 0.777 |
ALK2 |
0.769 | 0.105 | -2 | 0.754 |
MLK1 |
0.768 | -0.124 | 2 | 0.379 |
PRKD3 |
0.768 | 0.020 | -3 | 0.743 |
PAK2 |
0.768 | 0.053 | -2 | 0.810 |
BCKDK |
0.768 | -0.112 | -1 | 0.754 |
HIPK2 |
0.768 | 0.068 | 1 | 0.638 |
MASTL |
0.767 | -0.145 | -2 | 0.732 |
CDK8 |
0.767 | -0.004 | 1 | 0.653 |
DRAK1 |
0.767 | 0.154 | 1 | 0.735 |
DYRK3 |
0.767 | 0.128 | 1 | 0.739 |
HIPK1 |
0.767 | 0.068 | 1 | 0.727 |
ACVR2B |
0.767 | 0.078 | -2 | 0.742 |
SRPK3 |
0.766 | 0.038 | -3 | 0.709 |
NIM1 |
0.766 | -0.086 | 3 | 0.766 |
PLK1 |
0.766 | -0.020 | -2 | 0.726 |
DLK |
0.766 | -0.021 | 1 | 0.780 |
NEK7 |
0.766 | -0.164 | -3 | 0.822 |
BRSK1 |
0.766 | -0.009 | -3 | 0.792 |
WNK3 |
0.766 | -0.163 | 1 | 0.767 |
PLK3 |
0.765 | 0.023 | 2 | 0.447 |
PKG2 |
0.765 | 0.068 | -2 | 0.711 |
AMPKA2 |
0.764 | -0.029 | -3 | 0.821 |
MARK3 |
0.764 | 0.032 | 4 | 0.663 |
DNAPK |
0.764 | 0.058 | 1 | 0.679 |
ACVR2A |
0.764 | 0.034 | -2 | 0.733 |
AKT2 |
0.763 | 0.074 | -3 | 0.685 |
QSK |
0.763 | -0.009 | 4 | 0.719 |
ANKRD3 |
0.763 | -0.116 | 1 | 0.806 |
CDK19 |
0.763 | 0.001 | 1 | 0.617 |
P38B |
0.762 | 0.062 | 1 | 0.647 |
PASK |
0.762 | 0.176 | -3 | 0.842 |
P38A |
0.762 | 0.045 | 1 | 0.711 |
SGK3 |
0.761 | 0.043 | -3 | 0.763 |
PKCG |
0.761 | -0.031 | 2 | 0.324 |
IRE1 |
0.761 | -0.108 | 1 | 0.771 |
P38D |
0.761 | 0.086 | 1 | 0.565 |
PKCB |
0.761 | -0.038 | 2 | 0.309 |
SSTK |
0.761 | 0.011 | 4 | 0.718 |
PKR |
0.761 | -0.042 | 1 | 0.809 |
MLK3 |
0.761 | -0.095 | 2 | 0.320 |
CAMK1G |
0.761 | 0.038 | -3 | 0.759 |
CDK7 |
0.761 | -0.010 | 1 | 0.668 |
PKCA |
0.760 | -0.034 | 2 | 0.292 |
DYRK1B |
0.760 | 0.069 | 1 | 0.654 |
PKACA |
0.760 | 0.102 | -2 | 0.690 |
DYRK1A |
0.760 | 0.033 | 1 | 0.718 |
MEK1 |
0.760 | -0.046 | 2 | 0.425 |
GRK7 |
0.760 | 0.017 | 1 | 0.727 |
MLK2 |
0.759 | -0.144 | 2 | 0.351 |
TTBK2 |
0.759 | -0.173 | 2 | 0.301 |
MELK |
0.759 | -0.055 | -3 | 0.806 |
HIPK3 |
0.759 | 0.043 | 1 | 0.719 |
CHK1 |
0.759 | 0.000 | -3 | 0.825 |
CDK18 |
0.759 | 0.026 | 1 | 0.596 |
CDK1 |
0.759 | 0.038 | 1 | 0.631 |
NEK9 |
0.759 | -0.179 | 2 | 0.349 |
SMG1 |
0.759 | -0.013 | 1 | 0.755 |
SMMLCK |
0.758 | 0.104 | -3 | 0.808 |
CDK13 |
0.758 | 0.004 | 1 | 0.637 |
SNRK |
0.758 | -0.095 | 2 | 0.311 |
PIM2 |
0.758 | 0.028 | -3 | 0.742 |
QIK |
0.758 | -0.074 | -3 | 0.837 |
DCAMKL1 |
0.757 | 0.007 | -3 | 0.792 |
BRSK2 |
0.757 | -0.064 | -3 | 0.816 |
P38G |
0.757 | 0.041 | 1 | 0.545 |
CK2A2 |
0.757 | 0.093 | 1 | 0.722 |
TLK2 |
0.756 | -0.058 | 1 | 0.786 |
YSK4 |
0.756 | -0.048 | 1 | 0.716 |
VRK2 |
0.756 | -0.147 | 1 | 0.829 |
MARK1 |
0.756 | -0.005 | 4 | 0.695 |
ERK1 |
0.756 | 0.015 | 1 | 0.633 |
MARK2 |
0.755 | -0.034 | 4 | 0.638 |
NUAK1 |
0.755 | -0.063 | -3 | 0.787 |
IRE2 |
0.755 | -0.117 | 2 | 0.294 |
DAPK3 |
0.755 | 0.111 | -3 | 0.797 |
PKCH |
0.755 | -0.061 | 2 | 0.300 |
PLK4 |
0.755 | -0.114 | 2 | 0.316 |
NEK2 |
0.754 | -0.098 | 2 | 0.329 |
SIK |
0.754 | -0.043 | -3 | 0.768 |
PKCZ |
0.754 | -0.051 | 2 | 0.318 |
GRK2 |
0.754 | -0.015 | -2 | 0.632 |
DAPK1 |
0.754 | 0.126 | -3 | 0.776 |
MLK4 |
0.753 | -0.124 | 2 | 0.314 |
DCAMKL2 |
0.753 | -0.013 | -3 | 0.810 |
CDK5 |
0.753 | -0.013 | 1 | 0.686 |
PAK4 |
0.752 | 0.071 | -2 | 0.725 |
CDK12 |
0.751 | 0.003 | 1 | 0.610 |
PRP4 |
0.751 | 0.012 | -3 | 0.745 |
CDK9 |
0.751 | -0.007 | 1 | 0.640 |
ERK2 |
0.751 | -0.007 | 1 | 0.661 |
CDK14 |
0.750 | 0.030 | 1 | 0.633 |
AKT1 |
0.750 | 0.057 | -3 | 0.708 |
CDK17 |
0.750 | 0.010 | 1 | 0.546 |
CAMK1D |
0.750 | 0.034 | -3 | 0.677 |
PHKG1 |
0.750 | -0.117 | -3 | 0.825 |
PAK5 |
0.750 | 0.060 | -2 | 0.716 |
CK1E |
0.750 | -0.009 | -3 | 0.563 |
ERK7 |
0.750 | -0.034 | 2 | 0.209 |
GAK |
0.749 | 0.126 | 1 | 0.803 |
CK2A1 |
0.749 | 0.092 | 1 | 0.699 |
JNK1 |
0.749 | 0.073 | 1 | 0.598 |
TLK1 |
0.749 | -0.055 | -2 | 0.757 |
MEKK3 |
0.749 | -0.049 | 1 | 0.753 |
BRAF |
0.749 | -0.067 | -4 | 0.774 |
WNK4 |
0.748 | -0.086 | -2 | 0.829 |
CDK10 |
0.748 | 0.040 | 1 | 0.622 |
MAPKAPK5 |
0.746 | -0.075 | -3 | 0.716 |
CDK2 |
0.746 | -0.031 | 1 | 0.699 |
P70S6K |
0.746 | -0.019 | -3 | 0.704 |
CHAK1 |
0.746 | -0.166 | 2 | 0.302 |
MST3 |
0.745 | -0.024 | 2 | 0.409 |
CDK3 |
0.745 | 0.019 | 1 | 0.569 |
PERK |
0.744 | -0.159 | -2 | 0.758 |
PLK2 |
0.744 | 0.021 | -3 | 0.738 |
NEK5 |
0.744 | -0.101 | 1 | 0.789 |
GSK3B |
0.743 | -0.010 | 4 | 0.405 |
LKB1 |
0.743 | -0.002 | -3 | 0.826 |
PKCT |
0.743 | -0.052 | 2 | 0.289 |
MEK5 |
0.743 | -0.187 | 2 | 0.385 |
PKCI |
0.742 | -0.033 | 2 | 0.308 |
CDK16 |
0.742 | 0.008 | 1 | 0.562 |
PINK1 |
0.742 | -0.116 | 1 | 0.811 |
MPSK1 |
0.741 | -0.041 | 1 | 0.773 |
GSK3A |
0.741 | 0.000 | 4 | 0.412 |
GRK3 |
0.741 | -0.022 | -2 | 0.593 |
IRAK4 |
0.741 | -0.130 | 1 | 0.759 |
PKCE |
0.740 | -0.007 | 2 | 0.310 |
PHKG2 |
0.740 | -0.080 | -3 | 0.806 |
MRCKB |
0.740 | 0.071 | -3 | 0.736 |
HRI |
0.740 | -0.177 | -2 | 0.778 |
MAK |
0.740 | 0.046 | -2 | 0.709 |
MEKK2 |
0.740 | -0.159 | 2 | 0.346 |
CK1D |
0.739 | -0.006 | -3 | 0.519 |
CAMKK1 |
0.739 | -0.058 | -2 | 0.687 |
MEKK1 |
0.738 | -0.195 | 1 | 0.753 |
AKT3 |
0.738 | 0.048 | -3 | 0.621 |
TTBK1 |
0.738 | -0.153 | 2 | 0.277 |
SGK1 |
0.738 | 0.045 | -3 | 0.603 |
ZAK |
0.738 | -0.178 | 1 | 0.714 |
SBK |
0.738 | 0.044 | -3 | 0.568 |
CAMKK2 |
0.737 | -0.049 | -2 | 0.686 |
CHK2 |
0.737 | 0.021 | -3 | 0.636 |
MRCKA |
0.737 | 0.065 | -3 | 0.750 |
CAMK1A |
0.736 | 0.021 | -3 | 0.653 |
CK1G1 |
0.736 | -0.052 | -3 | 0.553 |
CK1A2 |
0.736 | -0.012 | -3 | 0.517 |
TAK1 |
0.736 | 0.031 | 1 | 0.798 |
ROCK2 |
0.736 | 0.060 | -3 | 0.786 |
BUB1 |
0.736 | 0.045 | -5 | 0.706 |
NEK11 |
0.735 | -0.089 | 1 | 0.734 |
DMPK1 |
0.735 | 0.116 | -3 | 0.759 |
NEK8 |
0.734 | -0.149 | 2 | 0.358 |
PKN1 |
0.734 | -0.037 | -3 | 0.725 |
GCK |
0.734 | 0.009 | 1 | 0.767 |
MOK |
0.733 | 0.026 | 1 | 0.778 |
TAO3 |
0.733 | -0.105 | 1 | 0.737 |
IRAK1 |
0.733 | -0.189 | -1 | 0.733 |
MST2 |
0.732 | -0.049 | 1 | 0.765 |
PDK1 |
0.732 | -0.086 | 1 | 0.734 |
HPK1 |
0.732 | 0.018 | 1 | 0.745 |
STK33 |
0.732 | -0.089 | 2 | 0.309 |
EEF2K |
0.731 | -0.067 | 3 | 0.764 |
MEKK6 |
0.731 | -0.102 | 1 | 0.759 |
YANK3 |
0.731 | -0.040 | 2 | 0.247 |
NEK4 |
0.728 | -0.138 | 1 | 0.743 |
TAO2 |
0.727 | -0.147 | 2 | 0.362 |
CDK4 |
0.726 | -0.012 | 1 | 0.598 |
TNIK |
0.726 | -0.063 | 3 | 0.795 |
PDHK3_TYR |
0.726 | 0.194 | 4 | 0.848 |
PKG1 |
0.726 | 0.025 | -2 | 0.663 |
CDK6 |
0.726 | -0.018 | 1 | 0.611 |
LRRK2 |
0.725 | -0.128 | 2 | 0.380 |
VRK1 |
0.725 | -0.098 | 2 | 0.398 |
NEK1 |
0.724 | -0.109 | 1 | 0.750 |
MINK |
0.723 | -0.109 | 1 | 0.745 |
HGK |
0.723 | -0.111 | 3 | 0.797 |
KHS1 |
0.723 | -0.037 | 1 | 0.737 |
MAP3K15 |
0.723 | -0.152 | 1 | 0.699 |
ROCK1 |
0.723 | 0.055 | -3 | 0.751 |
MST1 |
0.722 | -0.072 | 1 | 0.740 |
CRIK |
0.722 | 0.033 | -3 | 0.701 |
RIPK2 |
0.722 | -0.149 | 1 | 0.667 |
KHS2 |
0.721 | -0.022 | 1 | 0.752 |
LOK |
0.721 | -0.095 | -2 | 0.701 |
SLK |
0.721 | -0.050 | -2 | 0.626 |
PBK |
0.720 | -0.036 | 1 | 0.736 |
PDHK4_TYR |
0.719 | 0.190 | 2 | 0.475 |
MAP2K6_TYR |
0.718 | 0.193 | -1 | 0.858 |
EPHA6 |
0.718 | 0.139 | -1 | 0.857 |
HASPIN |
0.716 | 0.004 | -1 | 0.731 |
MEK2 |
0.716 | -0.202 | 2 | 0.361 |
PDHK1_TYR |
0.714 | 0.118 | -1 | 0.876 |
MAP2K4_TYR |
0.714 | 0.057 | -1 | 0.851 |
YSK1 |
0.714 | -0.149 | 2 | 0.328 |
BMPR2_TYR |
0.713 | 0.114 | -1 | 0.863 |
TESK1_TYR |
0.713 | -0.020 | 3 | 0.839 |
EPHA4 |
0.713 | 0.139 | 2 | 0.482 |
ALPHAK3 |
0.712 | -0.015 | -1 | 0.775 |
TTK |
0.711 | -0.098 | -2 | 0.745 |
EPHB4 |
0.710 | 0.107 | -1 | 0.823 |
MAP2K7_TYR |
0.708 | -0.072 | 2 | 0.423 |
PKMYT1_TYR |
0.708 | -0.091 | 3 | 0.826 |
OSR1 |
0.708 | -0.113 | 2 | 0.355 |
BIKE |
0.707 | -0.020 | 1 | 0.685 |
SRMS |
0.706 | 0.137 | 1 | 0.824 |
LIMK2_TYR |
0.705 | -0.049 | -3 | 0.881 |
NEK3 |
0.705 | -0.200 | 1 | 0.700 |
ASK1 |
0.705 | -0.135 | 1 | 0.679 |
CK1A |
0.705 | -0.039 | -3 | 0.430 |
TXK |
0.704 | 0.125 | 1 | 0.824 |
MYO3B |
0.704 | -0.101 | 2 | 0.335 |
PINK1_TYR |
0.702 | -0.135 | 1 | 0.791 |
EPHB1 |
0.702 | 0.093 | 1 | 0.815 |
EPHB2 |
0.701 | 0.095 | -1 | 0.801 |
ABL2 |
0.701 | 0.027 | -1 | 0.772 |
EPHB3 |
0.701 | 0.079 | -1 | 0.798 |
RET |
0.700 | -0.048 | 1 | 0.747 |
PTK2 |
0.700 | 0.145 | -1 | 0.820 |
ITK |
0.700 | 0.113 | -1 | 0.768 |
DDR1 |
0.700 | -0.004 | 4 | 0.757 |
YES1 |
0.698 | 0.005 | -1 | 0.814 |
BLK |
0.698 | 0.075 | -1 | 0.814 |
ABL1 |
0.698 | 0.011 | -1 | 0.761 |
TNK2 |
0.698 | 0.011 | 3 | 0.726 |
TYRO3 |
0.698 | -0.082 | 3 | 0.764 |
EPHA7 |
0.698 | 0.067 | 2 | 0.446 |
MYO3A |
0.697 | -0.138 | 1 | 0.740 |
MST1R |
0.697 | -0.074 | 3 | 0.789 |
FGR |
0.697 | -0.026 | 1 | 0.821 |
EPHA3 |
0.697 | 0.040 | 2 | 0.435 |
MERTK |
0.696 | 0.015 | 3 | 0.774 |
FYN |
0.696 | 0.095 | -1 | 0.797 |
CSF1R |
0.696 | -0.034 | 3 | 0.775 |
FER |
0.696 | -0.045 | 1 | 0.842 |
HCK |
0.696 | -0.008 | -1 | 0.803 |
INSRR |
0.695 | -0.021 | 3 | 0.726 |
BMX |
0.695 | 0.087 | -1 | 0.696 |
EPHA5 |
0.695 | 0.102 | 2 | 0.473 |
FGFR2 |
0.694 | -0.022 | 3 | 0.785 |
JAK3 |
0.694 | -0.021 | 1 | 0.723 |
PTK2B |
0.694 | 0.067 | -1 | 0.733 |
LCK |
0.693 | 0.017 | -1 | 0.810 |
ROS1 |
0.693 | -0.154 | 3 | 0.732 |
LIMK1_TYR |
0.693 | -0.211 | 2 | 0.367 |
KIT |
0.692 | 0.018 | 3 | 0.779 |
JAK2 |
0.692 | -0.151 | 1 | 0.738 |
AAK1 |
0.692 | 0.006 | 1 | 0.588 |
TEK |
0.691 | -0.023 | 3 | 0.711 |
TYK2 |
0.691 | -0.216 | 1 | 0.746 |
TAO1 |
0.690 | -0.172 | 1 | 0.660 |
AXL |
0.690 | -0.054 | 3 | 0.765 |
TEC |
0.689 | 0.017 | -1 | 0.702 |
KDR |
0.689 | -0.045 | 3 | 0.752 |
YANK2 |
0.688 | -0.077 | 2 | 0.245 |
DDR2 |
0.688 | 0.057 | 3 | 0.707 |
TNK1 |
0.687 | -0.088 | 3 | 0.759 |
STLK3 |
0.687 | -0.191 | 1 | 0.682 |
FGFR3 |
0.687 | 0.000 | 3 | 0.761 |
LYN |
0.686 | 0.018 | 3 | 0.721 |
MET |
0.685 | -0.032 | 3 | 0.765 |
FGFR1 |
0.685 | -0.104 | 3 | 0.750 |
FLT1 |
0.685 | 0.030 | -1 | 0.836 |
EPHA1 |
0.684 | -0.036 | 3 | 0.747 |
EPHA8 |
0.684 | 0.028 | -1 | 0.789 |
FRK |
0.684 | -0.008 | -1 | 0.806 |
EPHA2 |
0.683 | 0.073 | -1 | 0.772 |
FLT3 |
0.683 | -0.104 | 3 | 0.769 |
TNNI3K_TYR |
0.682 | -0.116 | 1 | 0.775 |
LTK |
0.682 | -0.101 | 3 | 0.720 |
NTRK1 |
0.682 | -0.094 | -1 | 0.789 |
SRC |
0.682 | 0.010 | -1 | 0.784 |
PDGFRB |
0.681 | -0.190 | 3 | 0.772 |
SYK |
0.681 | 0.075 | -1 | 0.790 |
CK1G3 |
0.680 | -0.048 | -3 | 0.384 |
WEE1_TYR |
0.680 | -0.074 | -1 | 0.724 |
FLT4 |
0.680 | -0.058 | 3 | 0.754 |
ERBB2 |
0.680 | -0.076 | 1 | 0.699 |
BTK |
0.679 | -0.081 | -1 | 0.722 |
CSK |
0.678 | -0.034 | 2 | 0.434 |
ALK |
0.677 | -0.153 | 3 | 0.687 |
NEK10_TYR |
0.677 | -0.149 | 1 | 0.616 |
FGFR4 |
0.676 | -0.014 | -1 | 0.754 |
EGFR |
0.676 | -0.035 | 1 | 0.605 |
INSR |
0.676 | -0.111 | 3 | 0.702 |
JAK1 |
0.676 | -0.160 | 1 | 0.681 |
PTK6 |
0.675 | -0.188 | -1 | 0.689 |
PDGFRA |
0.673 | -0.233 | 3 | 0.772 |
ERBB4 |
0.673 | 0.017 | 1 | 0.647 |
MATK |
0.672 | -0.057 | -1 | 0.703 |
NTRK3 |
0.672 | -0.104 | -1 | 0.737 |
NTRK2 |
0.672 | -0.172 | 3 | 0.758 |
IGF1R |
0.667 | -0.084 | 3 | 0.659 |
CK1G2 |
0.666 | -0.043 | -3 | 0.475 |
FES |
0.656 | -0.068 | -1 | 0.671 |
ZAP70 |
0.653 | 0.011 | -1 | 0.705 |
MUSK |
0.653 | -0.152 | 1 | 0.600 |