Motif 370 (n=133)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A3KN83 | SBNO1 | S212 | ochoa | Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) | Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250|UniProtKB:Q689Z5}. |
| A6H8Y1 | BDP1 | S420 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NKT7 | RGPD3 | S1479 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H8Y6P7 | GCOM1 | S665 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | None |
| J3KQ70 | INO80B-WBP1 | S97 | ochoa | HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) | None |
| O00567 | NOP56 | S528 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O00567 | NOP56 | S554 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14545 | TRAFD1 | S278 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14715 | RGPD8 | S1478 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15014 | ZNF609 | S576 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O43148 | RNMT | S72 | ochoa | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O60271 | SPAG9 | S728 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60315 | ZEB2 | S848 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O75970 | MPDZ | S352 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O94913 | PCF11 | S370 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94913 | PCF11 | S1493 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94986 | CEP152 | S1245 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95197 | RTN3 | S229 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| O95232 | LUC7L3 | S395 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| O95613 | PCNT | S2477 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P0CAP2 | POLR2M | S268 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}. |
| P0DJD0 | RGPD1 | S1463 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1471 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P11388 | TOP2A | S1504 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P20265 | POU3F2 | S339 | ochoa | POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7) | Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). {ECO:0000250|UniProtKB:P31360, ECO:0000250|UniProtKB:P56222}. |
| P23469 | PTPRE | S103 | ochoa | Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) | Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). {ECO:0000250}.; FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). {ECO:0000250}. |
| P27815 | PDE4A | S279 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P28290 | ITPRID2 | S352 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28715 | ERCC5 | S312 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P35611 | ADD1 | S481 | ochoa|psp | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P35659 | DEK | S230 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P38398 | BRCA1 | S1007 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42566 | EPS15 | S746 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42858 | HTT | S457 | ochoa|psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46019 | PHKA2 | S976 | ochoa | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
| P46821 | MAP1B | S1520 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49792 | RANBP2 | S2454 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50748 | KNTC1 | S1045 | ochoa | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| P50851 | LRBA | S1084 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P54132 | BLM | S336 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| Q01484 | ANK2 | S29 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S2248 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01831 | XPC | S350 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q08499 | PDE4D | S325 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q13085 | ACACA | S23 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13459 | MYO9B | S1043 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q14160 | SCRIB | S502 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14684 | RRP1B | S392 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14CB8 | ARHGAP19 | S468 | ochoa | Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q15637 | SF1 | Y87 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
| Q16513 | PKN2 | S620 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16659 | MAPK6 | S556 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q16760 | DGKD | S666 | ochoa | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q17R98 | ZNF827 | S687 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
| Q17RY0 | CPEB4 | S97 | ochoa | Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4) | Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195, ECO:0000269|PubMed:27857118}. |
| Q3B726 | POLR1F | S297 | ochoa | DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}. |
| Q4LE39 | ARID4B | S776 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q53GS9 | USP39 | S65 | ochoa | Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) | Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}. |
| Q5BKY9 | FAM133B | S194 | ochoa | Protein FAM133B | None |
| Q5BKY9 | FAM133B | S196 | ochoa | Protein FAM133B | None |
| Q5T200 | ZC3H13 | S877 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5TAX3 | TUT4 | S839 | ochoa | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| Q5VT06 | CEP350 | S103 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT06 | CEP350 | S2482 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5W0Z9 | ZDHHC20 | S328 | ochoa | Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:27153536, PubMed:29326245, PubMed:33219126). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245). May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. {ECO:0000250|UniProtKB:Q5Y5T1, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:29326245, ECO:0000269|PubMed:33219126}.; FUNCTION: (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q6P9G4 | TMEM154 | S115 | ochoa | Transmembrane protein 154 | None |
| Q6PCB5 | RSBN1L | S39 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6PJT7 | ZC3H14 | S579 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6UUV9 | CRTC1 | S170 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6VMQ6 | ATF7IP | S484 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6WKZ4 | RAB11FIP1 | S232 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZMS4 | ZNF852 | S143 | ochoa | Zinc finger protein 852 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6ZU35 | CRACD | S1137 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZUM4 | ARHGAP27 | S623 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q70Z53 | FRA10AC1 | S283 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
| Q7KZI7 | MARK2 | S422 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z3J3 | RGPD4 | S1479 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q8IYB3 | SRRM1 | S429 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYD8 | FANCM | S1794 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8N5C6 | SRBD1 | S149 | ochoa | S1 RNA-binding domain-containing protein 1 | None |
| Q8NCP5 | ZBTB44 | S159 | ochoa | Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) (Zinc finger protein 851) | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q8NG31 | KNL1 | S627 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NHV4 | NEDD1 | S516 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TD19 | NEK9 | S827 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TEW8 | PARD3B | S728 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8WW12 | PCNP | S46 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q8WXI2 | CNKSR2 | S388 | ochoa | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
| Q92545 | TMEM131 | S1423 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92793 | CREBBP | S1074 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92854 | SEMA4D | S798 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q92997 | DVL3 | S603 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96C24 | SYTL4 | S287 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96EB6 | SIRT1 | S569 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96PZ2 | FAM111A | Y24 | ochoa | Serine protease FAM111A (EC 3.4.21.-) | Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:32165630). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:32165630). Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors (PubMed:32165630). Required for PCNA loading on replication sites (PubMed:24561620). Promotes S-phase entry and DNA synthesis (PubMed:24561620). Also acts as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus (PubMed:23093934, PubMed:37607234). Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity (PubMed:33369867, PubMed:37607234). In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy (PubMed:37607234). {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:32165630, ECO:0000269|PubMed:37607234}. |
| Q99666 | RGPD5 | S1478 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99704 | DOK1 | S458 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q9BY89 | KIAA1671 | S1673 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYW2 | SETD2 | S742 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C086 | INO80B | S97 | ochoa | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}. |
| Q9C0F1 | CEP44 | S343 | ochoa | Centrosomal protein of 44 kDa (Cep44) (HBV PreS1-transactivated protein 3) (PS1TP3) | Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall (PubMed:32060285). Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome (PubMed:31974111). {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}. |
| Q9GZY8 | MFF | S123 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H063 | MAF1 | S207 | ochoa | Repressor of RNA polymerase III transcription MAF1 homolog | Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}. |
| Q9NQX7 | ITM2C | S22 | ochoa | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}. |
| Q9NY27 | PPP4R2 | S224 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9NY59 | SMPD3 | S296 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NYF8 | BCLAF1 | S181 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYF8 | BCLAF1 | S755 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYF8 | BCLAF1 | S757 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZN4 | EHD2 | S468 | ochoa | EH domain-containing protein 2 (PAST homolog 2) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). {ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:25588833}. |
| Q9P2D0 | IBTK | S1004 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9P2E9 | RRBP1 | S602 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UBC2 | EPS15L1 | S372 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UEY8 | ADD3 | S590 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UEY8 | ADD3 | S650 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHB6 | LIMA1 | S541 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB6 | LIMA1 | S617 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UIG0 | BAZ1B | S347 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UKV3 | ACIN1 | S386 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKV3 | ACIN1 | S525 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULT8 | HECTD1 | S1385 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9ULU4 | ZMYND8 | S650 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UN81 | L1RE1 | S25 | ochoa | LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) | Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}. |
| Q9Y232 | CDYL | S214 | ochoa | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) | [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:22009739, ECO:0000269|PubMed:28402439, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:29177481}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672). {ECO:0000269|PubMed:19808672}.; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. {ECO:0000269|PubMed:19808672}. |
| Q9Y2B0 | CNPY2 | S63 | ochoa | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| Q9Y467 | SALL2 | S872 | ochoa | Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2) | Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. {ECO:0000269|PubMed:24412933}. |
| Q9Y520 | PRRC2C | S1274 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y6M5 | SLC30A1 | S466 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y6Q9 | NCOA3 | S587 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| R4GMW8 | BIVM-ERCC5 | S766 | ochoa | DNA excision repair protein ERCC-5 | None |
| P13073 | COX4I1 | S72 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P11441 | UBL4A | S60 | Sugiyama | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892}. |
| P05362 | ICAM1 | S49 | Sugiyama | Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}. |
| Q9UQ07 | MOK | S315 | Sugiyama | MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) | Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.000304 | 3.517 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.000991 | 3.004 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.001800 | 2.745 |
| R-HSA-68877 | Mitotic Prometaphase | 0.003397 | 2.469 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.004627 | 2.335 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.004179 | 2.379 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.004525 | 2.344 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.005632 | 2.249 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.017971 | 1.745 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.017971 | 1.745 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.017971 | 1.745 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.017971 | 1.745 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.017971 | 1.745 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.017971 | 1.745 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.017971 | 1.745 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.044328 | 1.353 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.052956 | 1.276 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.061507 | 1.211 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.069982 | 1.155 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.078380 | 1.106 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.020403 | 1.690 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.103126 | 0.987 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.103126 | 0.987 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.022009 | 1.657 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.022009 | 1.657 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.022009 | 1.657 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.022009 | 1.657 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.127212 | 0.895 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.127212 | 0.895 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.032675 | 1.486 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.040693 | 1.390 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.051631 | 1.287 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.018491 | 1.733 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.056268 | 1.250 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.027329 | 1.563 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.027329 | 1.563 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.030348 | 1.518 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.038046 | 1.420 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.217299 | 0.663 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.217299 | 0.663 |
| R-HSA-380287 | Centrosome maturation | 0.040412 | 1.393 |
| R-HSA-72187 | mRNA 3'-end processing | 0.103558 | 0.985 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.054707 | 1.262 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.054707 | 1.262 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.058974 | 1.229 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.258816 | 0.587 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.272163 | 0.565 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.278746 | 0.555 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.285271 | 0.545 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.285271 | 0.545 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.298144 | 0.526 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.298144 | 0.526 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.304495 | 0.516 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.167608 | 0.776 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.310788 | 0.508 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.196782 | 0.706 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.142912 | 0.845 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.045502 | 1.342 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.061903 | 1.208 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.068459 | 1.165 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.051949 | 1.284 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.135158 | 0.869 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.135158 | 0.869 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.034615 | 1.461 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.053932 | 1.268 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.019849 | 1.702 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.047943 | 1.319 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.173474 | 0.761 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.217299 | 0.663 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.224375 | 0.649 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.258816 | 0.587 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.135158 | 0.869 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.135097 | 0.869 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.051631 | 1.287 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.245226 | 0.610 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.278746 | 0.555 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.323205 | 0.491 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.007363 | 2.133 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.009504 | 2.022 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.049367 | 1.307 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.049367 | 1.307 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.165936 | 0.780 |
| R-HSA-9664420 | Killing mechanisms | 0.165936 | 0.780 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.046643 | 1.331 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.107563 | 0.968 |
| R-HSA-72086 | mRNA Capping | 0.272163 | 0.565 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.310788 | 0.508 |
| R-HSA-72172 | mRNA Splicing | 0.054203 | 1.266 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.173474 | 0.761 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.224375 | 0.649 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.024999 | 1.602 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.323205 | 0.491 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.148624 | 0.828 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.127212 | 0.895 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.258816 | 0.587 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.080844 | 1.092 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.161232 | 0.793 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.304495 | 0.516 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.091148 | 1.040 |
| R-HSA-5693538 | Homology Directed Repair | 0.119100 | 0.924 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.253216 | 0.597 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.053320 | 1.273 |
| R-HSA-429947 | Deadenylation of mRNA | 0.030780 | 1.512 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.127212 | 0.895 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.135097 | 0.869 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.053932 | 1.268 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.224375 | 0.649 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.130130 | 0.886 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.304495 | 0.516 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.188346 | 0.725 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.118128 | 0.928 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.205611 | 0.687 |
| R-HSA-1500620 | Meiosis | 0.206646 | 0.685 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.094952 | 1.022 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.202953 | 0.693 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.202953 | 0.693 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.035754 | 1.447 |
| R-HSA-9620244 | Long-term potentiation | 0.245226 | 0.610 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.013431 | 1.872 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.008743 | 2.058 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.063484 | 1.197 |
| R-HSA-912446 | Meiotic recombination | 0.100708 | 0.997 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.291737 | 0.535 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.304495 | 0.516 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.173474 | 0.761 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.071104 | 1.148 |
| R-HSA-525793 | Myogenesis | 0.252051 | 0.599 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.052956 | 1.276 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.051949 | 1.284 |
| R-HSA-4086400 | PCP/CE pathway | 0.183729 | 0.736 |
| R-HSA-9909396 | Circadian clock | 0.151915 | 0.818 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.125035 | 0.903 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.238338 | 0.623 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.078380 | 1.106 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.056268 | 1.250 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.298144 | 0.526 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.310788 | 0.508 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.273294 | 0.563 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.124094 | 0.906 |
| R-HSA-182971 | EGFR downregulation | 0.044952 | 1.347 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.173474 | 0.761 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.317024 | 0.499 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.283330 | 0.548 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.283330 | 0.548 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.086703 | 1.062 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.094952 | 1.022 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.103126 | 0.987 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.135097 | 0.869 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.165936 | 0.780 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.217299 | 0.663 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.170813 | 0.767 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.229148 | 0.640 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.240989 | 0.618 |
| R-HSA-73886 | Chromosome Maintenance | 0.125035 | 0.903 |
| R-HSA-196780 | Biotin transport and metabolism | 0.013168 | 1.880 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.148624 | 0.828 |
| R-HSA-416700 | Other semaphorin interactions | 0.158330 | 0.800 |
| R-HSA-73894 | DNA Repair | 0.023159 | 1.635 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.103126 | 0.987 |
| R-HSA-8953854 | Metabolism of RNA | 0.155368 | 0.809 |
| R-HSA-9675135 | Diseases of DNA repair | 0.086808 | 1.061 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.061507 | 1.211 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.013168 | 1.880 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.188346 | 0.725 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.231388 | 0.636 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.231388 | 0.636 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.124094 | 0.906 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.279986 | 0.553 |
| R-HSA-68886 | M Phase | 0.075255 | 1.123 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.238338 | 0.623 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.044097 | 1.356 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.279986 | 0.553 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.036847 | 1.434 |
| R-HSA-3371556 | Cellular response to heat stress | 0.125035 | 0.903 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.103126 | 0.987 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.022009 | 1.657 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.252051 | 0.599 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.285271 | 0.545 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.035754 | 1.447 |
| R-HSA-9707616 | Heme signaling | 0.026360 | 1.579 |
| R-HSA-5617833 | Cilium Assembly | 0.294720 | 0.531 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.316663 | 0.499 |
| R-HSA-157579 | Telomere Maintenance | 0.256561 | 0.591 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.061507 | 1.211 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.258816 | 0.587 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.278746 | 0.555 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.070993 | 1.149 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.278746 | 0.555 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.200063 | 0.699 |
| R-HSA-69275 | G2/M Transition | 0.284884 | 0.545 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.023666 | 1.626 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.289799 | 0.538 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.158330 | 0.800 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.188346 | 0.725 |
| R-HSA-112311 | Neurotransmitter clearance | 0.278746 | 0.555 |
| R-HSA-177929 | Signaling by EGFR | 0.115174 | 0.939 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.197107 | 0.705 |
| R-HSA-1640170 | Cell Cycle | 0.034081 | 1.467 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.008435 | 2.074 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.051631 | 1.287 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.210158 | 0.677 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.278746 | 0.555 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.304495 | 0.516 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.109831 | 0.959 |
| R-HSA-9833110 | RSV-host interactions | 0.283330 | 0.548 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.272163 | 0.565 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.263254 | 0.580 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.103126 | 0.987 |
| R-HSA-200425 | Carnitine shuttle | 0.231388 | 0.636 |
| R-HSA-74160 | Gene expression (Transcription) | 0.261925 | 0.582 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.127103 | 0.896 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.081425 | 1.089 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.298144 | 0.526 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.158062 | 0.801 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.087279 | 1.059 |
| R-HSA-180024 | DARPP-32 events | 0.040693 | 1.390 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.202953 | 0.693 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.258816 | 0.587 |
| R-HSA-435354 | Zinc transporters | 0.150656 | 0.822 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.217299 | 0.663 |
| R-HSA-1538133 | G0 and Early G1 | 0.047140 | 1.327 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.304495 | 0.516 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.309514 | 0.509 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.111227 | 0.954 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.042802 | 1.369 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.224375 | 0.649 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.298144 | 0.526 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.200111 | 0.699 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.183729 | 0.736 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.253164 | 0.597 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.253164 | 0.597 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.245226 | 0.610 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.193507 | 0.713 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.065956 | 1.181 |
| R-HSA-9758941 | Gastrulation | 0.194065 | 0.712 |
| R-HSA-4839726 | Chromatin organization | 0.228444 | 0.641 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.310788 | 0.508 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.047140 | 1.327 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.317024 | 0.499 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.258013 | 0.588 |
| R-HSA-8853659 | RET signaling | 0.323205 | 0.491 |
| R-HSA-163685 | Integration of energy metabolism | 0.162709 | 0.789 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.213252 | 0.671 |
| R-HSA-75153 | Apoptotic execution phase | 0.086808 | 1.061 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.293355 | 0.533 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.154092 | 0.812 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.310788 | 0.508 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.293355 | 0.533 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.213252 | 0.671 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.233180 | 0.632 |
| R-HSA-111885 | Opioid Signalling | 0.279986 | 0.553 |
| R-HSA-1266738 | Developmental Biology | 0.328275 | 0.484 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.329330 | 0.482 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.329330 | 0.482 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.329330 | 0.482 |
| R-HSA-4641258 | Degradation of DVL | 0.329330 | 0.482 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.329330 | 0.482 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.333210 | 0.477 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.335400 | 0.474 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.335400 | 0.474 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.341415 | 0.467 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.341415 | 0.467 |
| R-HSA-68875 | Mitotic Prophase | 0.343084 | 0.465 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.347376 | 0.459 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.347376 | 0.459 |
| R-HSA-9646399 | Aggrephagy | 0.347376 | 0.459 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.347376 | 0.459 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.347376 | 0.459 |
| R-HSA-3371568 | Attenuation phase | 0.347376 | 0.459 |
| R-HSA-8982491 | Glycogen metabolism | 0.347376 | 0.459 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.353284 | 0.452 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.353284 | 0.452 |
| R-HSA-9694548 | Maturation of spike protein | 0.353284 | 0.452 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.359139 | 0.445 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.359139 | 0.445 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.359139 | 0.445 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.359139 | 0.445 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.359139 | 0.445 |
| R-HSA-68882 | Mitotic Anaphase | 0.361358 | 0.442 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.363819 | 0.439 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.364941 | 0.438 |
| R-HSA-418990 | Adherens junctions interactions | 0.366279 | 0.436 |
| R-HSA-69481 | G2/M Checkpoints | 0.369180 | 0.433 |
| R-HSA-8957322 | Metabolism of steroids | 0.379671 | 0.421 |
| R-HSA-774815 | Nucleosome assembly | 0.382035 | 0.418 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.382035 | 0.418 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.382035 | 0.418 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.382035 | 0.418 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.382035 | 0.418 |
| R-HSA-1474165 | Reproduction | 0.382079 | 0.418 |
| R-HSA-9843745 | Adipogenesis | 0.385286 | 0.414 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.387631 | 0.412 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.387631 | 0.412 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.387631 | 0.412 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.387631 | 0.412 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.387631 | 0.412 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.398673 | 0.399 |
| R-HSA-425410 | Metal ion SLC transporters | 0.398673 | 0.399 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.404119 | 0.393 |
| R-HSA-9766229 | Degradation of CDH1 | 0.404119 | 0.393 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.404378 | 0.393 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.404378 | 0.393 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.407533 | 0.390 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.413819 | 0.383 |
| R-HSA-9864848 | Complex IV assembly | 0.414866 | 0.382 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.414866 | 0.382 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.420166 | 0.377 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.420166 | 0.377 |
| R-HSA-1221632 | Meiotic synapsis | 0.425419 | 0.371 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.426292 | 0.370 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.426292 | 0.370 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.429389 | 0.367 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.435784 | 0.361 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.435784 | 0.361 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.438627 | 0.358 |
| R-HSA-75893 | TNF signaling | 0.440897 | 0.356 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.445963 | 0.351 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.445963 | 0.351 |
| R-HSA-421270 | Cell-cell junction organization | 0.446127 | 0.351 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.450984 | 0.346 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.450984 | 0.346 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.453843 | 0.343 |
| R-HSA-191859 | snRNP Assembly | 0.455960 | 0.341 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.455960 | 0.341 |
| R-HSA-186712 | Regulation of beta-cell development | 0.455960 | 0.341 |
| R-HSA-180786 | Extension of Telomeres | 0.455960 | 0.341 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.456858 | 0.340 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.460890 | 0.336 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.460890 | 0.336 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.460890 | 0.336 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.460890 | 0.336 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.460890 | 0.336 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.460890 | 0.336 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.460890 | 0.336 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.462860 | 0.335 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.465777 | 0.332 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.465777 | 0.332 |
| R-HSA-1989781 | PPARA activates gene expression | 0.465846 | 0.332 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.470619 | 0.327 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.470619 | 0.327 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.471790 | 0.326 |
| R-HSA-162587 | HIV Life Cycle | 0.471790 | 0.326 |
| R-HSA-373755 | Semaphorin interactions | 0.475418 | 0.323 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.475418 | 0.323 |
| R-HSA-8848021 | Signaling by PTK6 | 0.475418 | 0.323 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.475418 | 0.323 |
| R-HSA-877300 | Interferon gamma signaling | 0.477694 | 0.321 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.480631 | 0.318 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.484887 | 0.314 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.484887 | 0.314 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.485757 | 0.314 |
| R-HSA-109581 | Apoptosis | 0.486475 | 0.313 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.489557 | 0.310 |
| R-HSA-167172 | Transcription of the HIV genome | 0.498773 | 0.302 |
| R-HSA-913531 | Interferon Signaling | 0.499851 | 0.301 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.507822 | 0.294 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.507822 | 0.294 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.507822 | 0.294 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.507822 | 0.294 |
| R-HSA-446728 | Cell junction organization | 0.508435 | 0.294 |
| R-HSA-418555 | G alpha (s) signalling events | 0.515079 | 0.288 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.516710 | 0.287 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.525438 | 0.279 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.529743 | 0.276 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.529743 | 0.276 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.529743 | 0.276 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.534010 | 0.272 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.534010 | 0.272 |
| R-HSA-5689603 | UCH proteinases | 0.534010 | 0.272 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.538238 | 0.269 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.542428 | 0.266 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.542428 | 0.266 |
| R-HSA-216083 | Integrin cell surface interactions | 0.542428 | 0.266 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.547998 | 0.261 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.550694 | 0.259 |
| R-HSA-9833482 | PKR-mediated signaling | 0.550694 | 0.259 |
| R-HSA-6806834 | Signaling by MET | 0.550694 | 0.259 |
| R-HSA-195721 | Signaling by WNT | 0.552187 | 0.258 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.570718 | 0.244 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.570718 | 0.244 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.571652 | 0.243 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.578477 | 0.238 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.582304 | 0.235 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.582304 | 0.235 |
| R-HSA-9663891 | Selective autophagy | 0.586097 | 0.232 |
| R-HSA-1500931 | Cell-Cell communication | 0.589557 | 0.229 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.597271 | 0.224 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.597271 | 0.224 |
| R-HSA-391251 | Protein folding | 0.604553 | 0.219 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.604553 | 0.219 |
| R-HSA-5357801 | Programmed Cell Death | 0.606652 | 0.217 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.611704 | 0.213 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.615232 | 0.211 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.618191 | 0.209 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.622191 | 0.206 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.625624 | 0.204 |
| R-HSA-3214847 | HATs acetylate histones | 0.632397 | 0.199 |
| R-HSA-70171 | Glycolysis | 0.635738 | 0.197 |
| R-HSA-9675108 | Nervous system development | 0.641754 | 0.193 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.642329 | 0.192 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.642329 | 0.192 |
| R-HSA-8951664 | Neddylation | 0.643968 | 0.191 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.651994 | 0.186 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.652723 | 0.185 |
| R-HSA-162906 | HIV Infection | 0.657229 | 0.182 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.659401 | 0.181 |
| R-HSA-211000 | Gene Silencing by RNA | 0.661400 | 0.180 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.663712 | 0.178 |
| R-HSA-162582 | Signal Transduction | 0.668258 | 0.175 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.676519 | 0.170 |
| R-HSA-8939211 | ESR-mediated signaling | 0.678457 | 0.168 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.679461 | 0.168 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.688129 | 0.162 |
| R-HSA-373760 | L1CAM interactions | 0.693778 | 0.159 |
| R-HSA-70326 | Glucose metabolism | 0.696565 | 0.157 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.700032 | 0.155 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.707460 | 0.150 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.712762 | 0.147 |
| R-HSA-5688426 | Deubiquitination | 0.713977 | 0.146 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.715376 | 0.145 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.719393 | 0.143 |
| R-HSA-114608 | Platelet degranulation | 0.725601 | 0.139 |
| R-HSA-2262752 | Cellular responses to stress | 0.731535 | 0.136 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.742624 | 0.129 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.747868 | 0.126 |
| R-HSA-422475 | Axon guidance | 0.758043 | 0.120 |
| R-HSA-6807070 | PTEN Regulation | 0.758598 | 0.120 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.759464 | 0.119 |
| R-HSA-9658195 | Leishmania infection | 0.759464 | 0.119 |
| R-HSA-9664407 | Parasite infection | 0.760798 | 0.119 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.760798 | 0.119 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.760798 | 0.119 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.761083 | 0.119 |
| R-HSA-1632852 | Macroautophagy | 0.762978 | 0.117 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.762978 | 0.117 |
| R-HSA-9679506 | SARS-CoV Infections | 0.769985 | 0.114 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.772154 | 0.112 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.777696 | 0.109 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.782778 | 0.106 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.783723 | 0.106 |
| R-HSA-9609507 | Protein localization | 0.789587 | 0.103 |
| R-HSA-73887 | Death Receptor Signaling | 0.791507 | 0.102 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.793409 | 0.101 |
| R-HSA-9612973 | Autophagy | 0.795294 | 0.099 |
| R-HSA-9610379 | HCMV Late Events | 0.797162 | 0.098 |
| R-HSA-5619102 | SLC transporter disorders | 0.814933 | 0.089 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.819808 | 0.086 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.821600 | 0.085 |
| R-HSA-72306 | tRNA processing | 0.821600 | 0.085 |
| R-HSA-112316 | Neuronal System | 0.823169 | 0.085 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.823230 | 0.084 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.824844 | 0.084 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.828029 | 0.082 |
| R-HSA-611105 | Respiratory electron transport | 0.834228 | 0.079 |
| R-HSA-168255 | Influenza Infection | 0.835743 | 0.078 |
| R-HSA-449147 | Signaling by Interleukins | 0.841138 | 0.075 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.848771 | 0.071 |
| R-HSA-212436 | Generic Transcription Pathway | 0.854301 | 0.068 |
| R-HSA-109582 | Hemostasis | 0.859250 | 0.066 |
| R-HSA-9609690 | HCMV Early Events | 0.859487 | 0.066 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.864365 | 0.063 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.864559 | 0.063 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.865339 | 0.063 |
| R-HSA-428157 | Sphingolipid metabolism | 0.865798 | 0.063 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.867026 | 0.062 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.868243 | 0.061 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.879819 | 0.056 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.883515 | 0.054 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.894348 | 0.048 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.894868 | 0.048 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.897227 | 0.047 |
| R-HSA-72312 | rRNA processing | 0.900027 | 0.046 |
| R-HSA-418594 | G alpha (i) signalling events | 0.902343 | 0.045 |
| R-HSA-597592 | Post-translational protein modification | 0.904969 | 0.043 |
| R-HSA-157118 | Signaling by NOTCH | 0.907131 | 0.042 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.912934 | 0.040 |
| R-HSA-9609646 | HCMV Infection | 0.915309 | 0.038 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.919868 | 0.036 |
| R-HSA-416476 | G alpha (q) signalling events | 0.925570 | 0.034 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.929705 | 0.032 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.931826 | 0.031 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.936742 | 0.028 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.944106 | 0.025 |
| R-HSA-199991 | Membrane Trafficking | 0.944499 | 0.025 |
| R-HSA-9824446 | Viral Infection Pathways | 0.952787 | 0.021 |
| R-HSA-1474244 | Extracellular matrix organization | 0.959948 | 0.018 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.963495 | 0.016 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.963832 | 0.016 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.977058 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 0.977121 | 0.010 |
| R-HSA-5663205 | Infectious disease | 0.977459 | 0.010 |
| R-HSA-8978868 | Fatty acid metabolism | 0.980416 | 0.009 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.982138 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 0.982633 | 0.008 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.982970 | 0.007 |
| R-HSA-5668914 | Diseases of metabolism | 0.983746 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 0.987569 | 0.005 |
| R-HSA-6798695 | Neutrophil degranulation | 0.987716 | 0.005 |
| R-HSA-1280218 | Adaptive Immune System | 0.988927 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 0.990298 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.994887 | 0.002 |
| R-HSA-1643685 | Disease | 0.995591 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.999711 | 0.000 |
| R-HSA-168256 | Immune System | 0.999817 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.797 | 0.272 | 1 | 0.835 |
COT |
0.790 | 0.157 | 2 | 0.332 |
KIS |
0.781 | 0.159 | 1 | 0.750 |
CLK2 |
0.774 | 0.230 | -3 | 0.676 |
MOS |
0.774 | 0.128 | 1 | 0.834 |
PIM3 |
0.773 | 0.068 | -3 | 0.770 |
FAM20C |
0.773 | 0.008 | 2 | 0.234 |
CDC7 |
0.770 | 0.009 | 1 | 0.799 |
GRK1 |
0.769 | 0.094 | -2 | 0.788 |
NDR2 |
0.767 | 0.024 | -3 | 0.788 |
MTOR |
0.767 | 0.089 | 1 | 0.750 |
HIPK4 |
0.767 | 0.107 | 1 | 0.835 |
CAMK2G |
0.766 | -0.009 | 2 | 0.276 |
GCN2 |
0.765 | -0.059 | 2 | 0.242 |
SRPK1 |
0.764 | 0.069 | -3 | 0.660 |
BMPR1B |
0.764 | 0.186 | 1 | 0.774 |
DYRK4 |
0.764 | 0.224 | 1 | 0.716 |
DSTYK |
0.763 | 0.043 | 2 | 0.337 |
NLK |
0.763 | 0.032 | 1 | 0.836 |
ERK5 |
0.762 | 0.050 | 1 | 0.822 |
DYRK2 |
0.762 | 0.153 | 1 | 0.786 |
CDK1 |
0.762 | 0.134 | 1 | 0.701 |
RAF1 |
0.762 | 0.053 | 1 | 0.774 |
IKKB |
0.761 | 0.005 | -2 | 0.712 |
CAMK1B |
0.761 | 0.016 | -3 | 0.784 |
PRPK |
0.761 | -0.075 | -1 | 0.759 |
SKMLCK |
0.761 | 0.081 | -2 | 0.820 |
PIM1 |
0.761 | 0.046 | -3 | 0.705 |
CDKL1 |
0.760 | 0.024 | -3 | 0.713 |
GRK7 |
0.758 | 0.097 | 1 | 0.713 |
RIPK3 |
0.757 | 0.009 | 3 | 0.574 |
CHAK2 |
0.757 | -0.007 | -1 | 0.801 |
CAMK2B |
0.757 | 0.034 | 2 | 0.296 |
TBK1 |
0.757 | -0.058 | 1 | 0.663 |
BMPR2 |
0.757 | -0.012 | -2 | 0.866 |
GRK6 |
0.757 | 0.048 | 1 | 0.778 |
JNK2 |
0.757 | 0.155 | 1 | 0.682 |
NDR1 |
0.756 | -0.016 | -3 | 0.771 |
CDKL5 |
0.756 | 0.015 | -3 | 0.705 |
RSK2 |
0.756 | 0.010 | -3 | 0.699 |
NUAK2 |
0.755 | 0.021 | -3 | 0.780 |
HUNK |
0.755 | 0.005 | 2 | 0.324 |
CLK4 |
0.755 | 0.108 | -3 | 0.690 |
CDK8 |
0.755 | 0.067 | 1 | 0.724 |
ATR |
0.754 | -0.024 | 1 | 0.754 |
CAMK2A |
0.754 | 0.049 | 2 | 0.315 |
MLK1 |
0.754 | -0.064 | 2 | 0.262 |
IKKA |
0.754 | 0.012 | -2 | 0.704 |
ULK2 |
0.754 | -0.165 | 2 | 0.220 |
GRK5 |
0.754 | -0.050 | -3 | 0.789 |
IKKE |
0.754 | -0.047 | 1 | 0.660 |
ICK |
0.753 | 0.035 | -3 | 0.761 |
WNK1 |
0.753 | -0.020 | -2 | 0.837 |
PDHK4 |
0.753 | -0.154 | 1 | 0.788 |
PKN3 |
0.753 | -0.050 | -3 | 0.762 |
CLK1 |
0.753 | 0.098 | -3 | 0.671 |
PKN2 |
0.752 | -0.003 | -3 | 0.760 |
TGFBR1 |
0.752 | 0.089 | -2 | 0.807 |
P38B |
0.752 | 0.142 | 1 | 0.703 |
MARK4 |
0.752 | -0.010 | 4 | 0.848 |
CDK18 |
0.752 | 0.100 | 1 | 0.681 |
GRK4 |
0.752 | -0.013 | -2 | 0.821 |
CAMLCK |
0.752 | -0.001 | -2 | 0.816 |
CDK19 |
0.752 | 0.078 | 1 | 0.695 |
JNK3 |
0.751 | 0.129 | 1 | 0.713 |
PRKD2 |
0.751 | 0.013 | -3 | 0.699 |
NIK |
0.750 | -0.055 | -3 | 0.810 |
NEK6 |
0.750 | -0.086 | -2 | 0.835 |
MST4 |
0.750 | -0.043 | 2 | 0.272 |
ULK1 |
0.750 | -0.134 | -3 | 0.763 |
TGFBR2 |
0.750 | -0.050 | -2 | 0.809 |
MLK3 |
0.750 | -0.040 | 2 | 0.223 |
PKCD |
0.750 | -0.044 | 2 | 0.231 |
PLK3 |
0.749 | 0.053 | 2 | 0.313 |
HIPK2 |
0.749 | 0.104 | 1 | 0.715 |
P38A |
0.749 | 0.121 | 1 | 0.766 |
BMPR1A |
0.749 | 0.151 | 1 | 0.754 |
DLK |
0.749 | 0.039 | 1 | 0.762 |
CDK3 |
0.749 | 0.109 | 1 | 0.652 |
NEK7 |
0.749 | -0.119 | -3 | 0.781 |
P90RSK |
0.749 | -0.022 | -3 | 0.700 |
SRPK2 |
0.749 | 0.022 | -3 | 0.583 |
LATS1 |
0.748 | 0.058 | -3 | 0.819 |
AURC |
0.748 | 0.020 | -2 | 0.619 |
CDK5 |
0.748 | 0.061 | 1 | 0.752 |
PLK1 |
0.748 | -0.003 | -2 | 0.803 |
RSK4 |
0.747 | 0.022 | -3 | 0.685 |
ALK2 |
0.747 | 0.112 | -2 | 0.816 |
PRKD1 |
0.747 | -0.024 | -3 | 0.749 |
LATS2 |
0.747 | -0.035 | -5 | 0.724 |
ALK4 |
0.746 | 0.039 | -2 | 0.830 |
CAMK2D |
0.746 | -0.051 | -3 | 0.763 |
DAPK2 |
0.746 | -0.022 | -3 | 0.794 |
PKACG |
0.746 | -0.020 | -2 | 0.723 |
PASK |
0.746 | 0.188 | -3 | 0.797 |
P38G |
0.746 | 0.101 | 1 | 0.627 |
ERK1 |
0.746 | 0.090 | 1 | 0.696 |
DRAK1 |
0.746 | 0.146 | 1 | 0.716 |
P70S6KB |
0.746 | -0.024 | -3 | 0.715 |
MAPKAPK2 |
0.746 | 0.003 | -3 | 0.656 |
RSK3 |
0.745 | -0.032 | -3 | 0.688 |
PAK1 |
0.745 | -0.028 | -2 | 0.760 |
CDK7 |
0.745 | 0.051 | 1 | 0.735 |
CDK2 |
0.745 | 0.064 | 1 | 0.756 |
ACVR2B |
0.745 | 0.097 | -2 | 0.807 |
P38D |
0.745 | 0.142 | 1 | 0.646 |
CDK17 |
0.745 | 0.085 | 1 | 0.632 |
MLK4 |
0.744 | -0.064 | 2 | 0.217 |
AMPKA1 |
0.744 | -0.059 | -3 | 0.784 |
TSSK2 |
0.744 | -0.036 | -5 | 0.816 |
RIPK1 |
0.744 | -0.068 | 1 | 0.779 |
PRP4 |
0.743 | 0.090 | -3 | 0.724 |
MASTL |
0.743 | -0.137 | -2 | 0.807 |
TTBK2 |
0.743 | -0.140 | 2 | 0.196 |
ANKRD3 |
0.742 | -0.101 | 1 | 0.805 |
PKR |
0.742 | -0.025 | 1 | 0.811 |
ATM |
0.742 | -0.007 | 1 | 0.692 |
GSK3A |
0.742 | 0.091 | 4 | 0.560 |
MLK2 |
0.742 | -0.100 | 2 | 0.243 |
ACVR2A |
0.742 | 0.054 | -2 | 0.797 |
HIPK1 |
0.742 | 0.071 | 1 | 0.798 |
PDHK1 |
0.742 | -0.227 | 1 | 0.770 |
MAPKAPK3 |
0.742 | -0.033 | -3 | 0.696 |
MARK3 |
0.742 | 0.049 | 4 | 0.802 |
CDK13 |
0.742 | 0.045 | 1 | 0.711 |
SRPK3 |
0.742 | 0.010 | -3 | 0.626 |
TSSK1 |
0.741 | -0.043 | -3 | 0.810 |
PKCB |
0.741 | -0.055 | 2 | 0.221 |
WNK3 |
0.740 | -0.183 | 1 | 0.748 |
MYLK4 |
0.740 | 0.037 | -2 | 0.736 |
IRE1 |
0.740 | -0.110 | 1 | 0.780 |
MEK1 |
0.740 | -0.022 | 2 | 0.292 |
PRKX |
0.740 | 0.035 | -3 | 0.629 |
MNK2 |
0.740 | -0.029 | -2 | 0.743 |
NIM1 |
0.739 | -0.113 | 3 | 0.635 |
CAMK4 |
0.739 | -0.056 | -3 | 0.755 |
PKACB |
0.739 | 0.018 | -2 | 0.644 |
MSK1 |
0.739 | 0.026 | -3 | 0.654 |
ERK2 |
0.739 | 0.059 | 1 | 0.719 |
PKCA |
0.738 | -0.064 | 2 | 0.209 |
PLK4 |
0.738 | -0.080 | 2 | 0.188 |
NEK9 |
0.738 | -0.170 | 2 | 0.239 |
PKCG |
0.738 | -0.061 | 2 | 0.229 |
PAK3 |
0.738 | -0.072 | -2 | 0.757 |
CDK14 |
0.737 | 0.076 | 1 | 0.718 |
ERK7 |
0.737 | -0.011 | 2 | 0.161 |
YSK4 |
0.737 | -0.023 | 1 | 0.702 |
QSK |
0.737 | -0.018 | 4 | 0.820 |
MNK1 |
0.737 | -0.020 | -2 | 0.753 |
AMPKA2 |
0.737 | -0.061 | -3 | 0.753 |
TLK2 |
0.736 | -0.039 | 1 | 0.731 |
DYRK1B |
0.736 | 0.083 | 1 | 0.742 |
PLK2 |
0.736 | 0.072 | -3 | 0.789 |
CAMK1G |
0.736 | 0.003 | -3 | 0.677 |
DYRK3 |
0.736 | 0.084 | 1 | 0.808 |
BRSK1 |
0.735 | -0.062 | -3 | 0.713 |
CK2A2 |
0.735 | 0.062 | 1 | 0.669 |
BCKDK |
0.735 | -0.173 | -1 | 0.687 |
JNK1 |
0.735 | 0.118 | 1 | 0.670 |
CDK16 |
0.734 | 0.076 | 1 | 0.644 |
CDK10 |
0.734 | 0.074 | 1 | 0.712 |
GRK2 |
0.734 | -0.002 | -2 | 0.701 |
IRE2 |
0.734 | -0.125 | 2 | 0.194 |
PKCZ |
0.734 | -0.070 | 2 | 0.223 |
CK1E |
0.734 | 0.002 | -3 | 0.523 |
PAK6 |
0.734 | -0.031 | -2 | 0.666 |
GAK |
0.734 | 0.196 | 1 | 0.841 |
AURB |
0.734 | -0.019 | -2 | 0.621 |
MARK2 |
0.734 | -0.010 | 4 | 0.773 |
CDK12 |
0.734 | 0.039 | 1 | 0.687 |
MSK2 |
0.734 | -0.038 | -3 | 0.646 |
DYRK1A |
0.733 | 0.040 | 1 | 0.778 |
DNAPK |
0.733 | 0.013 | 1 | 0.620 |
PAK2 |
0.733 | -0.067 | -2 | 0.747 |
GSK3B |
0.733 | 0.055 | 4 | 0.550 |
VRK2 |
0.733 | -0.146 | 1 | 0.834 |
MEKK3 |
0.733 | 0.004 | 1 | 0.743 |
CDK9 |
0.732 | 0.031 | 1 | 0.719 |
PKCH |
0.732 | -0.093 | 2 | 0.207 |
QIK |
0.732 | -0.084 | -3 | 0.763 |
PIM2 |
0.732 | -0.004 | -3 | 0.663 |
MARK1 |
0.731 | -0.006 | 4 | 0.806 |
AURA |
0.731 | -0.001 | -2 | 0.591 |
MELK |
0.731 | -0.092 | -3 | 0.731 |
DCAMKL1 |
0.731 | -0.027 | -3 | 0.722 |
DCAMKL2 |
0.731 | -0.029 | -3 | 0.747 |
NUAK1 |
0.731 | -0.076 | -3 | 0.722 |
CHK1 |
0.730 | -0.029 | -3 | 0.783 |
BRSK2 |
0.730 | -0.082 | -3 | 0.739 |
PRKD3 |
0.730 | -0.047 | -3 | 0.656 |
SMG1 |
0.729 | -0.034 | 1 | 0.701 |
CHAK1 |
0.729 | -0.141 | 2 | 0.197 |
MPSK1 |
0.729 | 0.041 | 1 | 0.811 |
PKG2 |
0.729 | -0.037 | -2 | 0.645 |
PHKG1 |
0.728 | -0.113 | -3 | 0.756 |
CK2A1 |
0.728 | 0.071 | 1 | 0.644 |
SIK |
0.728 | -0.055 | -3 | 0.680 |
SGK3 |
0.728 | -0.043 | -3 | 0.683 |
MST3 |
0.727 | -0.003 | 2 | 0.299 |
NEK2 |
0.727 | -0.150 | 2 | 0.223 |
HIPK3 |
0.727 | 0.028 | 1 | 0.778 |
TLK1 |
0.727 | -0.042 | -2 | 0.822 |
PERK |
0.726 | -0.113 | -2 | 0.834 |
SNRK |
0.726 | -0.155 | 2 | 0.206 |
CK1D |
0.726 | 0.016 | -3 | 0.470 |
AKT2 |
0.726 | -0.014 | -3 | 0.607 |
MAK |
0.724 | 0.091 | -2 | 0.763 |
GRK3 |
0.724 | -0.004 | -2 | 0.663 |
SSTK |
0.724 | -0.057 | 4 | 0.792 |
MEKK2 |
0.723 | -0.120 | 2 | 0.237 |
BRAF |
0.723 | -0.099 | -4 | 0.815 |
CK1A2 |
0.723 | -0.001 | -3 | 0.467 |
MEK5 |
0.723 | -0.157 | 2 | 0.264 |
NEK5 |
0.723 | -0.091 | 1 | 0.777 |
PINK1 |
0.722 | -0.082 | 1 | 0.843 |
ZAK |
0.722 | -0.129 | 1 | 0.717 |
TAO3 |
0.721 | -0.044 | 1 | 0.732 |
HRI |
0.720 | -0.147 | -2 | 0.849 |
PKACA |
0.720 | -0.014 | -2 | 0.590 |
SMMLCK |
0.719 | -0.020 | -3 | 0.734 |
BUB1 |
0.719 | 0.087 | -5 | 0.780 |
TTBK1 |
0.719 | -0.137 | 2 | 0.175 |
CK1G1 |
0.719 | -0.049 | -3 | 0.508 |
CDK6 |
0.719 | 0.041 | 1 | 0.702 |
WNK4 |
0.719 | -0.138 | -2 | 0.836 |
GCK |
0.718 | 0.057 | 1 | 0.736 |
MEKK1 |
0.718 | -0.177 | 1 | 0.751 |
STK33 |
0.718 | -0.069 | 2 | 0.210 |
NEK11 |
0.718 | -0.047 | 1 | 0.735 |
IRAK4 |
0.718 | -0.145 | 1 | 0.769 |
YANK3 |
0.718 | -0.035 | 2 | 0.173 |
PKCE |
0.717 | -0.048 | 2 | 0.218 |
PKCI |
0.717 | -0.084 | 2 | 0.213 |
CAMK1D |
0.715 | -0.036 | -3 | 0.605 |
PKCT |
0.715 | -0.111 | 2 | 0.200 |
EEF2K |
0.713 | -0.065 | 3 | 0.691 |
MST2 |
0.713 | -0.027 | 1 | 0.737 |
CAMKK1 |
0.713 | -0.080 | -2 | 0.704 |
NEK8 |
0.713 | -0.135 | 2 | 0.248 |
MOK |
0.713 | 0.044 | 1 | 0.823 |
LKB1 |
0.713 | -0.033 | -3 | 0.782 |
P70S6K |
0.712 | -0.071 | -3 | 0.615 |
DAPK3 |
0.712 | -0.018 | -3 | 0.727 |
TAK1 |
0.712 | 0.021 | 1 | 0.747 |
MAPKAPK5 |
0.712 | -0.120 | -3 | 0.620 |
CDK4 |
0.712 | 0.029 | 1 | 0.674 |
PAK5 |
0.711 | -0.065 | -2 | 0.616 |
DAPK1 |
0.710 | -0.002 | -3 | 0.703 |
PDHK3_TYR |
0.709 | 0.173 | 4 | 0.874 |
PAK4 |
0.709 | -0.066 | -2 | 0.618 |
PHKG2 |
0.709 | -0.123 | -3 | 0.732 |
HPK1 |
0.709 | 0.008 | 1 | 0.723 |
AKT1 |
0.709 | -0.052 | -3 | 0.632 |
SLK |
0.708 | -0.009 | -2 | 0.697 |
CAMKK2 |
0.708 | -0.079 | -2 | 0.698 |
TAO2 |
0.708 | -0.127 | 2 | 0.251 |
PDHK4_TYR |
0.707 | 0.242 | 2 | 0.345 |
TNIK |
0.706 | -0.062 | 3 | 0.742 |
PDK1 |
0.706 | -0.101 | 1 | 0.759 |
LRRK2 |
0.706 | -0.107 | 2 | 0.260 |
ROCK2 |
0.705 | -0.012 | -3 | 0.717 |
MRCKA |
0.705 | -0.009 | -3 | 0.679 |
VRK1 |
0.704 | -0.095 | 2 | 0.280 |
MST1 |
0.704 | -0.043 | 1 | 0.719 |
LOK |
0.703 | -0.078 | -2 | 0.744 |
CHK2 |
0.703 | -0.032 | -3 | 0.556 |
IRAK1 |
0.703 | -0.218 | -1 | 0.692 |
SGK1 |
0.703 | -0.030 | -3 | 0.526 |
MAP3K15 |
0.703 | -0.120 | 1 | 0.702 |
MAP2K6_TYR |
0.702 | 0.211 | -1 | 0.779 |
PBK |
0.702 | 0.020 | 1 | 0.783 |
NEK4 |
0.702 | -0.156 | 1 | 0.730 |
MRCKB |
0.702 | -0.027 | -3 | 0.654 |
HASPIN |
0.702 | 0.011 | -1 | 0.702 |
KHS2 |
0.702 | -0.030 | 1 | 0.726 |
HGK |
0.701 | -0.119 | 3 | 0.730 |
MEKK6 |
0.701 | -0.138 | 1 | 0.729 |
NEK1 |
0.701 | -0.115 | 1 | 0.748 |
MINK |
0.701 | -0.111 | 1 | 0.726 |
BMPR2_TYR |
0.700 | 0.143 | -1 | 0.794 |
ALPHAK3 |
0.700 | 0.033 | -1 | 0.686 |
CAMK1A |
0.699 | -0.051 | -3 | 0.567 |
PKN1 |
0.699 | -0.095 | -3 | 0.641 |
PDHK1_TYR |
0.698 | 0.134 | -1 | 0.808 |
EPHA4 |
0.698 | 0.154 | 2 | 0.355 |
DMPK1 |
0.697 | 0.017 | -3 | 0.688 |
AKT3 |
0.697 | -0.047 | -3 | 0.543 |
KHS1 |
0.697 | -0.067 | 1 | 0.716 |
OSR1 |
0.697 | -0.048 | 2 | 0.251 |
EPHA6 |
0.696 | 0.095 | -1 | 0.782 |
MAP2K4_TYR |
0.696 | 0.072 | -1 | 0.776 |
TESK1_TYR |
0.696 | -0.013 | 3 | 0.757 |
MEK2 |
0.696 | -0.172 | 2 | 0.236 |
TTK |
0.695 | -0.061 | -2 | 0.825 |
CK1A |
0.695 | -0.013 | -3 | 0.386 |
BIKE |
0.695 | 0.048 | 1 | 0.762 |
EPHB4 |
0.694 | 0.118 | -1 | 0.741 |
TXK |
0.694 | 0.177 | 1 | 0.764 |
MAP2K7_TYR |
0.693 | -0.039 | 2 | 0.290 |
SBK |
0.693 | -0.021 | -3 | 0.489 |
RIPK2 |
0.691 | -0.185 | 1 | 0.677 |
YSK1 |
0.691 | -0.152 | 2 | 0.227 |
CRIK |
0.690 | -0.020 | -3 | 0.628 |
PKMYT1_TYR |
0.689 | -0.082 | 3 | 0.709 |
ROCK1 |
0.689 | -0.031 | -3 | 0.673 |
LIMK2_TYR |
0.688 | -0.040 | -3 | 0.827 |
ITK |
0.687 | 0.158 | -1 | 0.727 |
PTK2 |
0.686 | 0.150 | -1 | 0.726 |
SRMS |
0.686 | 0.145 | 1 | 0.774 |
PINK1_TYR |
0.685 | -0.126 | 1 | 0.784 |
EPHB2 |
0.684 | 0.108 | -1 | 0.731 |
YANK2 |
0.684 | -0.050 | 2 | 0.171 |
YES1 |
0.684 | 0.042 | -1 | 0.766 |
ABL2 |
0.683 | 0.058 | -1 | 0.730 |
RET |
0.683 | -0.045 | 1 | 0.735 |
MYO3B |
0.682 | -0.103 | 2 | 0.224 |
PKG1 |
0.682 | -0.084 | -2 | 0.558 |
EPHB1 |
0.682 | 0.080 | 1 | 0.771 |
EPHB3 |
0.682 | 0.077 | -1 | 0.725 |
FYN |
0.681 | 0.136 | -1 | 0.750 |
AAK1 |
0.681 | 0.072 | 1 | 0.685 |
BLK |
0.681 | 0.106 | -1 | 0.782 |
TYRO3 |
0.681 | -0.068 | 3 | 0.655 |
MYO3A |
0.680 | -0.115 | 1 | 0.740 |
ASK1 |
0.680 | -0.139 | 1 | 0.689 |
CSF1R |
0.679 | -0.014 | 3 | 0.644 |
ABL1 |
0.679 | 0.036 | -1 | 0.725 |
TNK2 |
0.679 | -0.008 | 3 | 0.605 |
EPHA7 |
0.678 | 0.056 | 2 | 0.323 |
EPHA5 |
0.678 | 0.106 | 2 | 0.349 |
NEK3 |
0.678 | -0.212 | 1 | 0.706 |
LCK |
0.678 | 0.069 | -1 | 0.773 |
FGR |
0.678 | -0.006 | 1 | 0.787 |
BMX |
0.678 | 0.100 | -1 | 0.659 |
MST1R |
0.678 | -0.076 | 3 | 0.669 |
PTK2B |
0.677 | 0.099 | -1 | 0.701 |
FGFR2 |
0.677 | -0.033 | 3 | 0.661 |
EPHA3 |
0.677 | 0.031 | 2 | 0.314 |
DDR1 |
0.677 | -0.064 | 4 | 0.784 |
LIMK1_TYR |
0.676 | -0.189 | 2 | 0.242 |
FER |
0.676 | -0.035 | 1 | 0.790 |
MERTK |
0.676 | 0.001 | 3 | 0.642 |
HCK |
0.675 | 0.009 | -1 | 0.764 |
KIT |
0.675 | 0.028 | 3 | 0.651 |
FLT1 |
0.674 | 0.054 | -1 | 0.747 |
INSRR |
0.674 | -0.063 | 3 | 0.601 |
JAK3 |
0.674 | -0.045 | 1 | 0.716 |
TEK |
0.673 | -0.016 | 3 | 0.591 |
MET |
0.672 | 0.015 | 3 | 0.658 |
FGFR3 |
0.672 | 0.006 | 3 | 0.637 |
TEC |
0.672 | 0.034 | -1 | 0.671 |
SYK |
0.672 | 0.127 | -1 | 0.704 |
TAO1 |
0.672 | -0.152 | 1 | 0.663 |
EPHA8 |
0.671 | 0.056 | -1 | 0.728 |
STLK3 |
0.671 | -0.152 | 1 | 0.673 |
KDR |
0.671 | -0.057 | 3 | 0.613 |
JAK2 |
0.671 | -0.166 | 1 | 0.727 |
ROS1 |
0.670 | -0.199 | 3 | 0.607 |
CK1G3 |
0.669 | -0.030 | -3 | 0.339 |
AXL |
0.669 | -0.073 | 3 | 0.633 |
FRK |
0.668 | 0.025 | -1 | 0.790 |
EPHA2 |
0.668 | 0.086 | -1 | 0.696 |
TYK2 |
0.667 | -0.267 | 1 | 0.733 |
TNK1 |
0.667 | -0.124 | 3 | 0.638 |
FLT3 |
0.666 | -0.094 | 3 | 0.648 |
SRC |
0.666 | 0.046 | -1 | 0.740 |
BTK |
0.665 | -0.035 | -1 | 0.699 |
LYN |
0.665 | 0.034 | 3 | 0.549 |
FGFR1 |
0.665 | -0.119 | 3 | 0.619 |
CK1G2 |
0.665 | 0.006 | -3 | 0.431 |
WEE1_TYR |
0.665 | -0.077 | -1 | 0.663 |
DDR2 |
0.665 | 0.001 | 3 | 0.587 |
EPHA1 |
0.664 | -0.045 | 3 | 0.634 |
PDGFRB |
0.664 | -0.194 | 3 | 0.652 |
NEK10_TYR |
0.664 | -0.126 | 1 | 0.607 |
MATK |
0.663 | -0.027 | -1 | 0.669 |
CSK |
0.662 | -0.015 | 2 | 0.306 |
ERBB2 |
0.662 | -0.067 | 1 | 0.685 |
FGFR4 |
0.662 | -0.002 | -1 | 0.675 |
EGFR |
0.660 | -0.023 | 1 | 0.592 |
FLT4 |
0.659 | -0.088 | 3 | 0.595 |
PTK6 |
0.659 | -0.165 | -1 | 0.632 |
LTK |
0.658 | -0.146 | 3 | 0.590 |
TNNI3K_TYR |
0.658 | -0.159 | 1 | 0.767 |
NTRK1 |
0.657 | -0.136 | -1 | 0.692 |
ERBB4 |
0.655 | 0.024 | 1 | 0.619 |
ALK |
0.655 | -0.182 | 3 | 0.565 |
JAK1 |
0.654 | -0.179 | 1 | 0.676 |
PDGFRA |
0.653 | -0.243 | 3 | 0.648 |
ZAP70 |
0.651 | 0.071 | -1 | 0.625 |
INSR |
0.651 | -0.156 | 3 | 0.573 |
NTRK3 |
0.649 | -0.128 | -1 | 0.642 |
NTRK2 |
0.648 | -0.199 | 3 | 0.598 |
IGF1R |
0.645 | -0.110 | 3 | 0.525 |
FES |
0.638 | -0.062 | -1 | 0.626 |
MUSK |
0.634 | -0.149 | 1 | 0.596 |