Motif 37 (n=75)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | T553 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A0U1RQJ8 | ATRIP | S37 | ochoa | ATR interacting protein | None |
| A0JNW5 | BLTP3B | S891 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A7MBM2 | DISP2 | S1235 | ochoa | Protein dispatched homolog 2 | None |
| O00170 | AIP | S159 | ochoa | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O43896 | KIF1C | S494 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60333 | KIF1B | S527 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O75369 | FLNB | S1529 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S2184 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75694 | NUP155 | S1057 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O95772 | STARD3NL | S204 | ochoa | STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog) | Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}. |
| O95793 | STAU1 | S465 | ochoa | Double-stranded RNA-binding protein Staufen homolog 1 | Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; FUNCTION: (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. {ECO:0000269|PubMed:10325410, ECO:0000269|PubMed:18498651, ECO:0000269|PubMed:23926355, ECO:0000269|PubMed:30301857}. |
| P0C0S8 | H2AC11 | T102 | ochoa | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P11387 | TOP1 | S112 | ochoa|psp | DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter. {ECO:0000250|UniProtKB:Q13472, ECO:0000269|PubMed:14594810, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:22904072, ECO:0000269|PubMed:2833744}. |
| P20671 | H2AC7 | T102 | ochoa | Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P20807 | CAPN3 | S629 | psp | Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1) | Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:27657329}. |
| P29692 | EEF1D | S119 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P34910 | EVI2B | S242 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P41182 | BCL6 | S404 | ochoa | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P49006 | MARCKSL1 | S41 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P78347 | GTF2I | S146 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78527 | PRKDC | S687 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P85037 | FOXK1 | S299 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q01167 | FOXK2 | S252 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02790 | FKBP4 | S350 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q08211 | DHX9 | S87 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12756 | KIF1A | S487 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12788 | TBL3 | S257 | ochoa | Transducin beta-like protein 3 (WD repeat-containing protein SAZD) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q12851 | MAP4K2 | S387 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q12980 | NPRL3 | S189 | ochoa | GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:29590090, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:29590090, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:35338845}. |
| Q13459 | MYO9B | S83 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13796 | SHROOM2 | S1524 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14849 | STARD3 | S203 | psp | StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3) | Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464, PubMed:33124732). The sterol transport mechanism is triggered by phosphorylation of FFAT motif that leads to membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464, PubMed:33124732). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544). {ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:12070139, ECO:0000269|PubMed:15930133, ECO:0000269|PubMed:19965586, ECO:0000269|PubMed:21322544, ECO:0000269|PubMed:22514632, ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464, ECO:0000269|PubMed:33124732}. |
| Q15468 | STIL | S753 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q15697 | ZNF174 | S188 | ochoa | Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) | Transcriptional repressor. {ECO:0000269|PubMed:7673192}. |
| Q16777 | H2AC20 | T102 | ochoa | Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5TC12 | ATPAF1 | S40 | ochoa | ATP synthase mitochondrial F1 complex assembly factor 1 (ATP11 homolog) | Has a complex stabilizing activity in the assembly of the mitochondrial F1-F0 complex. {ECO:0000250|UniProtKB:Q811I0}. |
| Q641Q2 | WASHC2A | S787 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68EM7 | ARHGAP17 | S162 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6FI13 | H2AC18 | T102 | ochoa | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6PIY7 | TENT2 | S62 | ochoa|psp | Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}. |
| Q6UB99 | ANKRD11 | S1307 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UXM1 | LRIG3 | S949 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) | May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}. |
| Q6V0I7 | FAT4 | S4716 | ochoa | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}. |
| Q6ZRS2 | SRCAP | T572 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q7Z4H7 | HAUS6 | S805 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z6I6 | ARHGAP30 | S349 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6J0 | SH3RF1 | S561 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q86UE4 | MTDH | S311 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86WB0 | ZC3HC1 | S163 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q8IVT2 | MISP | S284 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IXJ9 | ASXL1 | S503 | ochoa | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:30982744, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:36180891}. |
| Q8N3X1 | FNBP4 | S432 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8NFI3 | ENGASE | S673 | ochoa | Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) | Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. {ECO:0000269|PubMed:12114544}. |
| Q8WXE1 | ATRIP | S224 | ochoa|psp | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WYP5 | AHCTF1 | S528 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q93077 | H2AC6 | T102 | ochoa | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96AP0 | ACD | S25 | psp | Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein) | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318, ECO:0000269|PubMed:25205116, ECO:0000269|PubMed:25233904}. |
| Q96CC6 | RHBDF1 | S61 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96DY7 | MTBP | S639 | ochoa | Mdm2-binding protein (hMTBP) | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}. |
| Q96F24 | NRBF2 | S120 | ochoa|psp | Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}. |
| Q96KK5 | H2AC12 | T102 | ochoa | Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99878 | H2AC14 | T102 | ochoa | Histone H2A type 1-J (Histone H2A/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9C0C2 | TNKS1BP1 | S601 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9NWS1 | PARPBP | S154 | ochoa | PCNA-interacting partner (PARI) (PARP-1 binding protein) (PARP1-binding protein) (PARPBP) | Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect. {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}. |
| Q9P0V3 | SH3BP4 | S271 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9UGU0 | TCF20 | S1522 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UJU5 | FOXD3 | S46 | ochoa | Forkhead box protein D3 (HNF3/FH transcription factor genesis) | Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor (PubMed:11891324). Also acts as a transcriptional activator (PubMed:11891324). Negatively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). Promotes development of neural crest cells from neural tube progenitors (PubMed:11891324). Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation (PubMed:11891324). Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (PubMed:11891324). {ECO:0000269|PubMed:11891324, ECO:0000269|PubMed:22306510}. |
| Q9UKL3 | CASP8AP2 | S1368 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKV3 | ACIN1 | S522 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULD5 | ZNF777 | S496 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9ULL8 | SHROOM4 | S686 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9UPN3 | MACF1 | S5592 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y314 | NOSIP | S152 | ochoa | Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. |
| O95881 | TXNDC12 | S136 | Sugiyama | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5689603 | UCH proteinases | 2.267608e-11 | 10.644 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.083751e-10 | 9.389 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.512339e-09 | 8.820 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.126292e-08 | 7.948 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.269676e-08 | 7.644 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.185697e-08 | 7.285 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 8.082479e-08 | 7.092 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.219815e-07 | 6.914 |
| R-HSA-73927 | Depurination | 1.390268e-07 | 6.857 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.790202e-07 | 6.747 |
| R-HSA-5688426 | Deubiquitination | 1.653387e-07 | 6.782 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.563731e-07 | 6.591 |
| R-HSA-73928 | Depyrimidination | 2.563731e-07 | 6.591 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 8.647984e-07 | 6.063 |
| R-HSA-1221632 | Meiotic synapsis | 8.086120e-07 | 6.092 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 8.878875e-07 | 6.052 |
| R-HSA-5334118 | DNA methylation | 1.151414e-06 | 5.939 |
| R-HSA-9609690 | HCMV Early Events | 1.641502e-06 | 5.785 |
| R-HSA-3214847 | HATs acetylate histones | 1.685864e-06 | 5.773 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.780620e-06 | 5.749 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.946741e-06 | 5.711 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.480003e-06 | 5.606 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.121930e-06 | 5.506 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.488337e-06 | 5.457 |
| R-HSA-9610379 | HCMV Late Events | 3.392289e-06 | 5.470 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.810638e-06 | 5.419 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.793665e-06 | 5.319 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.304680e-06 | 5.275 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.304680e-06 | 5.275 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.644103e-06 | 5.178 |
| R-HSA-9710421 | Defective pyroptosis | 7.097878e-06 | 5.149 |
| R-HSA-774815 | Nucleosome assembly | 8.535075e-06 | 5.069 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 8.535075e-06 | 5.069 |
| R-HSA-1500620 | Meiosis | 8.924465e-06 | 5.049 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 9.334094e-06 | 5.030 |
| R-HSA-9609646 | HCMV Infection | 1.018245e-05 | 4.992 |
| R-HSA-73884 | Base Excision Repair | 1.267619e-05 | 4.897 |
| R-HSA-912446 | Meiotic recombination | 1.424761e-05 | 4.846 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.543527e-05 | 4.811 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.669872e-05 | 4.777 |
| R-HSA-157579 | Telomere Maintenance | 2.060460e-05 | 4.686 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.427372e-05 | 4.615 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.063156e-05 | 4.514 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.063156e-05 | 4.514 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.795858e-05 | 4.553 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.795858e-05 | 4.553 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.206380e-05 | 4.494 |
| R-HSA-211000 | Gene Silencing by RNA | 3.527394e-05 | 4.453 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.166713e-05 | 4.380 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.336051e-05 | 4.273 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.723443e-05 | 4.326 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.838558e-05 | 4.315 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.336051e-05 | 4.273 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.664489e-05 | 4.247 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.664489e-05 | 4.247 |
| R-HSA-68875 | Mitotic Prophase | 6.769638e-05 | 4.169 |
| R-HSA-73886 | Chromosome Maintenance | 7.050028e-05 | 4.152 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.547708e-05 | 4.122 |
| R-HSA-73864 | RNA Polymerase I Transcription | 8.423046e-05 | 4.075 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.638620e-05 | 4.117 |
| R-HSA-4839726 | Chromatin organization | 7.202167e-05 | 4.143 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.594394e-05 | 4.066 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.594394e-05 | 4.066 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.594394e-05 | 4.066 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 9.374518e-05 | 4.028 |
| R-HSA-977225 | Amyloid fiber formation | 9.880187e-05 | 4.005 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.040656e-04 | 3.983 |
| R-HSA-1474165 | Reproduction | 1.079139e-04 | 3.967 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.152374e-04 | 3.938 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.389560e-04 | 3.857 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.472023e-04 | 3.832 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.693941e-04 | 3.771 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.940564e-04 | 3.712 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.598478e-04 | 3.585 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.964516e-04 | 3.528 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.964516e-04 | 3.528 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.043465e-04 | 3.393 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.639381e-04 | 3.334 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.639381e-04 | 3.334 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 4.682876e-04 | 3.329 |
| R-HSA-2559583 | Cellular Senescence | 5.591977e-04 | 3.252 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 6.131908e-04 | 3.212 |
| R-HSA-73894 | DNA Repair | 7.260921e-04 | 3.139 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.340546e-04 | 3.079 |
| R-HSA-68886 | M Phase | 1.057882e-03 | 2.976 |
| R-HSA-1640170 | Cell Cycle | 1.173596e-03 | 2.930 |
| R-HSA-418990 | Adherens junctions interactions | 1.399531e-03 | 2.854 |
| R-HSA-69306 | DNA Replication | 1.871368e-03 | 2.728 |
| R-HSA-8939211 | ESR-mediated signaling | 2.056255e-03 | 2.687 |
| R-HSA-421270 | Cell-cell junction organization | 2.672812e-03 | 2.573 |
| R-HSA-157118 | Signaling by NOTCH | 2.178232e-03 | 2.662 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.007352e-03 | 2.522 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.019734e-03 | 2.520 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.455119e-03 | 2.462 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.810751e-03 | 2.419 |
| R-HSA-446728 | Cell junction organization | 4.242201e-03 | 2.372 |
| R-HSA-597592 | Post-translational protein modification | 4.330846e-03 | 2.363 |
| R-HSA-983189 | Kinesins | 5.201481e-03 | 2.284 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 5.269933e-03 | 2.278 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.339634e-03 | 2.272 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 6.280133e-03 | 2.202 |
| R-HSA-2262752 | Cellular responses to stress | 6.283214e-03 | 2.202 |
| R-HSA-196108 | Pregnenolone biosynthesis | 7.371266e-03 | 2.132 |
| R-HSA-1500931 | Cell-Cell communication | 7.490431e-03 | 2.125 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 7.570834e-03 | 2.121 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.243804e-03 | 2.084 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.591298e-03 | 2.066 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 9.155995e-03 | 2.038 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 9.857977e-03 | 2.006 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.180321e-02 | 1.928 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.358494e-02 | 1.867 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.487198e-02 | 1.828 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.760195e-02 | 1.754 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.237154e-02 | 1.650 |
| R-HSA-195721 | Signaling by WNT | 2.342527e-02 | 1.630 |
| R-HSA-3371568 | Attenuation phase | 2.424596e-02 | 1.615 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 3.502519e-02 | 1.456 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.674785e-02 | 1.435 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.902797e-02 | 1.409 |
| R-HSA-3371556 | Cellular response to heat stress | 3.197515e-02 | 1.495 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.788125e-02 | 1.422 |
| R-HSA-392499 | Metabolism of proteins | 3.462736e-02 | 1.461 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 3.992884e-02 | 1.399 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 3.992884e-02 | 1.399 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 3.992884e-02 | 1.399 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 3.992884e-02 | 1.399 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.022093e-02 | 1.396 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 5.377001e-02 | 1.269 |
| R-HSA-212436 | Generic Transcription Pathway | 5.453096e-02 | 1.263 |
| R-HSA-196071 | Metabolism of steroid hormones | 5.639248e-02 | 1.249 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.797357e-02 | 1.237 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.176865e-02 | 1.209 |
| R-HSA-9824446 | Viral Infection Pathways | 6.634571e-02 | 1.178 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.731231e-02 | 1.172 |
| R-HSA-8852135 | Protein ubiquitination | 6.731231e-02 | 1.172 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.731231e-02 | 1.172 |
| R-HSA-9020591 | Interleukin-12 signaling | 6.872336e-02 | 1.163 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 7.357194e-02 | 1.133 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.446410e-02 | 1.128 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.696750e-02 | 1.114 |
| R-HSA-9005895 | Pervasive developmental disorders | 7.828204e-02 | 1.106 |
| R-HSA-9697154 | Disorders of Nervous System Development | 7.828204e-02 | 1.106 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 7.828204e-02 | 1.106 |
| R-HSA-447115 | Interleukin-12 family signaling | 8.638198e-02 | 1.064 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 9.227089e-02 | 1.035 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 9.227089e-02 | 1.035 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 9.227089e-02 | 1.035 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.345898e-02 | 1.029 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.060500e-01 | 0.974 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 1.548284e-01 | 0.810 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.634104e-01 | 0.787 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.676690e-01 | 0.776 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.719062e-01 | 0.765 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.719062e-01 | 0.765 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.803168e-01 | 0.744 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.803168e-01 | 0.744 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.844905e-01 | 0.734 |
| R-HSA-171319 | Telomere Extension By Telomerase | 1.591302e-01 | 0.798 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 1.461595e-01 | 0.835 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.803168e-01 | 0.744 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.329913e-01 | 0.876 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.676690e-01 | 0.776 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.844905e-01 | 0.734 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.803168e-01 | 0.744 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.886431e-01 | 0.724 |
| R-HSA-429947 | Deadenylation of mRNA | 1.417922e-01 | 0.848 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.886431e-01 | 0.724 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.133890e-01 | 0.945 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.014801e-01 | 0.994 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.761221e-01 | 0.754 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.886431e-01 | 0.724 |
| R-HSA-74160 | Gene expression (Transcription) | 1.308786e-01 | 0.883 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.105969e-01 | 0.956 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.329913e-01 | 0.876 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.803168e-01 | 0.744 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.151210e-01 | 0.939 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.014198e-01 | 0.994 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.761221e-01 | 0.754 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.084747e-01 | 0.965 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.927748e-01 | 0.715 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.927748e-01 | 0.715 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.956944e-01 | 0.708 |
| R-HSA-3371511 | HSF1 activation | 1.968857e-01 | 0.706 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.009760e-01 | 0.697 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.050457e-01 | 0.688 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.050457e-01 | 0.688 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 2.050457e-01 | 0.688 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.090949e-01 | 0.680 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.090949e-01 | 0.680 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.090949e-01 | 0.680 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.131237e-01 | 0.671 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.131237e-01 | 0.671 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.131237e-01 | 0.671 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.131237e-01 | 0.671 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.165849e-01 | 0.664 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.171323e-01 | 0.663 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.171323e-01 | 0.663 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.211207e-01 | 0.655 |
| R-HSA-9711097 | Cellular response to starvation | 2.259254e-01 | 0.646 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.353106e-01 | 0.628 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.368745e-01 | 0.625 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 2.368745e-01 | 0.625 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.407635e-01 | 0.618 |
| R-HSA-9675135 | Diseases of DNA repair | 2.407635e-01 | 0.618 |
| R-HSA-75153 | Apoptotic execution phase | 2.407635e-01 | 0.618 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.484829e-01 | 0.605 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.484829e-01 | 0.605 |
| R-HSA-9766229 | Degradation of CDH1 | 2.523134e-01 | 0.598 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 2.523134e-01 | 0.598 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.523134e-01 | 0.598 |
| R-HSA-5663205 | Infectious disease | 2.525522e-01 | 0.598 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.599168e-01 | 0.585 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.785927e-01 | 0.555 |
| R-HSA-69275 | G2/M Transition | 2.804866e-01 | 0.552 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.822716e-01 | 0.549 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.822716e-01 | 0.549 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.822716e-01 | 0.549 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.842541e-01 | 0.546 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 2.859320e-01 | 0.544 |
| R-HSA-180786 | Extension of Telomeres | 2.895739e-01 | 0.538 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.895739e-01 | 0.538 |
| R-HSA-191859 | snRNP Assembly | 2.895739e-01 | 0.538 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.895739e-01 | 0.538 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.917842e-01 | 0.535 |
| R-HSA-8873719 | RAB geranylgeranylation | 2.931975e-01 | 0.533 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 2.931975e-01 | 0.533 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 2.931975e-01 | 0.533 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 2.931975e-01 | 0.533 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 2.931975e-01 | 0.533 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 2.931975e-01 | 0.533 |
| R-HSA-68877 | Mitotic Prometaphase | 2.936654e-01 | 0.532 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.955460e-01 | 0.529 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.968029e-01 | 0.528 |
| R-HSA-9707616 | Heme signaling | 3.003901e-01 | 0.522 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.003901e-01 | 0.522 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.003901e-01 | 0.522 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.039592e-01 | 0.517 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.039592e-01 | 0.517 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.039592e-01 | 0.517 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.145589e-01 | 0.502 |
| R-HSA-72172 | mRNA Splicing | 3.161820e-01 | 0.500 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.180566e-01 | 0.497 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.215366e-01 | 0.493 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.234679e-01 | 0.490 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.329718e-01 | 0.478 |
| R-HSA-68882 | Mitotic Anaphase | 3.385446e-01 | 0.470 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.386755e-01 | 0.470 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.386755e-01 | 0.470 |
| R-HSA-913531 | Interferon Signaling | 3.390009e-01 | 0.470 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.403993e-01 | 0.468 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.420516e-01 | 0.466 |
| R-HSA-1236394 | Signaling by ERBB4 | 3.420516e-01 | 0.466 |
| R-HSA-168256 | Immune System | 3.447143e-01 | 0.463 |
| R-HSA-380287 | Centrosome maturation | 3.454106e-01 | 0.462 |
| R-HSA-1980143 | Signaling by NOTCH1 | 3.487528e-01 | 0.457 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 3.520780e-01 | 0.453 |
| R-HSA-9833482 | PKR-mediated signaling | 3.619535e-01 | 0.441 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.652122e-01 | 0.437 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.652122e-01 | 0.437 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.684545e-01 | 0.434 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 3.716803e-01 | 0.430 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.748899e-01 | 0.426 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.812606e-01 | 0.419 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.812606e-01 | 0.419 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.844219e-01 | 0.415 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.906966e-01 | 0.408 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.969081e-01 | 0.401 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.999904e-01 | 0.398 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.061083e-01 | 0.391 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.147954e-01 | 0.382 |
| R-HSA-449147 | Signaling by Interleukins | 4.186528e-01 | 0.378 |
| R-HSA-5389840 | Mitochondrial translation elongation | 4.211348e-01 | 0.376 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.211348e-01 | 0.376 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.240948e-01 | 0.373 |
| R-HSA-5368286 | Mitochondrial translation initiation | 4.270397e-01 | 0.370 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.328851e-01 | 0.364 |
| R-HSA-70171 | Glycolysis | 4.328851e-01 | 0.364 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 4.415429e-01 | 0.355 |
| R-HSA-8953854 | Metabolism of RNA | 4.427961e-01 | 0.354 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.556834e-01 | 0.341 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.556834e-01 | 0.341 |
| R-HSA-5419276 | Mitochondrial translation termination | 4.612400e-01 | 0.336 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.612400e-01 | 0.336 |
| R-HSA-1280218 | Adaptive Immune System | 4.621730e-01 | 0.335 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.694700e-01 | 0.328 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.748876e-01 | 0.323 |
| R-HSA-70326 | Glucose metabolism | 4.881936e-01 | 0.311 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.881936e-01 | 0.311 |
| R-HSA-5693538 | Homology Directed Repair | 4.908146e-01 | 0.309 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.985981e-01 | 0.302 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.062642e-01 | 0.296 |
| R-HSA-69481 | G2/M Checkpoints | 5.163057e-01 | 0.287 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.188212e-01 | 0.285 |
| R-HSA-8957322 | Metabolism of steroids | 5.251123e-01 | 0.280 |
| R-HSA-9843745 | Adipogenesis | 5.285743e-01 | 0.277 |
| R-HSA-9909396 | Circadian clock | 5.309909e-01 | 0.275 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 5.309909e-01 | 0.275 |
| R-HSA-5368287 | Mitochondrial translation | 5.475677e-01 | 0.262 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.475677e-01 | 0.262 |
| R-HSA-9664407 | Parasite infection | 5.521967e-01 | 0.258 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.521967e-01 | 0.258 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.521967e-01 | 0.258 |
| R-HSA-1266738 | Developmental Biology | 5.531462e-01 | 0.257 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.544936e-01 | 0.256 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.590526e-01 | 0.253 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.590526e-01 | 0.253 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.768323e-01 | 0.239 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.875830e-01 | 0.231 |
| R-HSA-1989781 | PPARA activates gene expression | 5.875830e-01 | 0.231 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.918073e-01 | 0.228 |
| R-HSA-162587 | HIV Life Cycle | 5.918073e-01 | 0.228 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.980638e-01 | 0.223 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.980638e-01 | 0.223 |
| R-HSA-109581 | Apoptosis | 6.021820e-01 | 0.220 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.062586e-01 | 0.217 |
| R-HSA-5619102 | SLC transporter disorders | 6.122962e-01 | 0.213 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.202044e-01 | 0.207 |
| R-HSA-72306 | tRNA processing | 6.202044e-01 | 0.207 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.279531e-01 | 0.202 |
| R-HSA-168255 | Influenza Infection | 6.374197e-01 | 0.196 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.538638e-01 | 0.185 |
| R-HSA-5617833 | Cilium Assembly | 6.574168e-01 | 0.182 |
| R-HSA-199991 | Membrane Trafficking | 6.672909e-01 | 0.176 |
| R-HSA-72766 | Translation | 6.714171e-01 | 0.173 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.796488e-01 | 0.168 |
| R-HSA-5357801 | Programmed Cell Death | 6.845733e-01 | 0.165 |
| R-HSA-162582 | Signal Transduction | 7.090589e-01 | 0.149 |
| R-HSA-1643685 | Disease | 7.145670e-01 | 0.146 |
| R-HSA-162906 | HIV Infection | 7.184722e-01 | 0.144 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.199245e-01 | 0.143 |
| R-HSA-72312 | rRNA processing | 7.256597e-01 | 0.139 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.461522e-01 | 0.127 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.618242e-01 | 0.118 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.723241e-01 | 0.112 |
| R-HSA-109582 | Hemostasis | 7.835410e-01 | 0.106 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.838317e-01 | 0.106 |
| R-HSA-9658195 | Leishmania infection | 7.871706e-01 | 0.104 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.871706e-01 | 0.104 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.882722e-01 | 0.103 |
| R-HSA-9679506 | SARS-CoV Infections | 7.961030e-01 | 0.099 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.002102e-01 | 0.097 |
| R-HSA-1474244 | Extracellular matrix organization | 8.358766e-01 | 0.078 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.505648e-01 | 0.070 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.755067e-01 | 0.058 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.984764e-01 | 0.046 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.146029e-01 | 0.039 |
| R-HSA-168249 | Innate Immune System | 9.206455e-01 | 0.036 |
| R-HSA-211859 | Biological oxidations | 9.402771e-01 | 0.027 |
| R-HSA-422475 | Axon guidance | 9.468197e-01 | 0.024 |
| R-HSA-9675108 | Nervous system development | 9.562637e-01 | 0.019 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.628852e-01 | 0.016 |
| R-HSA-556833 | Metabolism of lipids | 9.859071e-01 | 0.006 |
| R-HSA-1430728 | Metabolism | 9.999703e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
P38G |
0.806 | 0.682 | 1 | 0.866 |
CDK3 |
0.805 | 0.615 | 1 | 0.868 |
CDK1 |
0.803 | 0.642 | 1 | 0.842 |
ERK1 |
0.801 | 0.654 | 1 | 0.853 |
CDK19 |
0.801 | 0.642 | 1 | 0.840 |
CDK13 |
0.801 | 0.660 | 1 | 0.846 |
P38D |
0.801 | 0.666 | 1 | 0.865 |
CDK5 |
0.800 | 0.638 | 1 | 0.813 |
CDK18 |
0.800 | 0.661 | 1 | 0.852 |
CDK12 |
0.800 | 0.670 | 1 | 0.855 |
CDK8 |
0.800 | 0.644 | 1 | 0.828 |
HIPK2 |
0.799 | 0.590 | 1 | 0.830 |
KIS |
0.799 | 0.584 | 1 | 0.840 |
P38B |
0.799 | 0.659 | 1 | 0.857 |
CDK17 |
0.794 | 0.647 | 1 | 0.865 |
P38A |
0.793 | 0.655 | 1 | 0.802 |
JNK2 |
0.790 | 0.649 | 1 | 0.857 |
CDK9 |
0.790 | 0.641 | 1 | 0.838 |
CDK16 |
0.789 | 0.639 | 1 | 0.862 |
PRP4 |
0.789 | 0.679 | -3 | 0.864 |
CDK7 |
0.789 | 0.618 | 1 | 0.835 |
JNK3 |
0.786 | 0.633 | 1 | 0.854 |
DYRK2 |
0.785 | 0.573 | 1 | 0.788 |
CDK2 |
0.783 | 0.533 | 1 | 0.769 |
HIPK1 |
0.782 | 0.526 | 1 | 0.777 |
NLK |
0.781 | 0.589 | 1 | 0.654 |
ERK2 |
0.781 | 0.617 | 1 | 0.812 |
CDK14 |
0.779 | 0.610 | 1 | 0.827 |
CDK6 |
0.779 | 0.607 | 1 | 0.836 |
CDK4 |
0.778 | 0.615 | 1 | 0.858 |
CDK10 |
0.778 | 0.573 | 1 | 0.835 |
HIPK3 |
0.777 | 0.518 | 1 | 0.757 |
DYRK1A |
0.776 | 0.468 | 1 | 0.773 |
HIPK4 |
0.774 | 0.366 | 1 | 0.623 |
CLK3 |
0.773 | 0.337 | 1 | 0.635 |
DYRK4 |
0.772 | 0.554 | 1 | 0.850 |
ERK5 |
0.770 | 0.329 | 1 | 0.597 |
DYRK1B |
0.768 | 0.527 | 1 | 0.815 |
JNK1 |
0.766 | 0.561 | 1 | 0.862 |
CDKL5 |
0.765 | 0.166 | -3 | 0.545 |
DYRK3 |
0.762 | 0.414 | 1 | 0.746 |
SRPK1 |
0.762 | 0.226 | -3 | 0.526 |
ICK |
0.761 | 0.283 | -3 | 0.577 |
MAK |
0.760 | 0.393 | -2 | 0.803 |
CLK1 |
0.756 | 0.287 | -3 | 0.492 |
ERK7 |
0.756 | 0.271 | 2 | 0.614 |
CDKL1 |
0.756 | 0.109 | -3 | 0.550 |
MOS |
0.754 | 0.018 | 1 | 0.397 |
MTOR |
0.753 | 0.125 | 1 | 0.464 |
CLK4 |
0.752 | 0.255 | -3 | 0.521 |
SRPK2 |
0.749 | 0.163 | -3 | 0.460 |
PRPK |
0.749 | -0.063 | -1 | 0.795 |
SRPK3 |
0.747 | 0.143 | -3 | 0.496 |
MOK |
0.746 | 0.344 | 1 | 0.686 |
BMPR2 |
0.745 | -0.098 | -2 | 0.770 |
CDC7 |
0.745 | -0.073 | 1 | 0.342 |
ATR |
0.743 | -0.058 | 1 | 0.353 |
NEK6 |
0.743 | -0.037 | -2 | 0.748 |
TBK1 |
0.742 | -0.083 | 1 | 0.302 |
MST4 |
0.742 | 0.027 | 2 | 0.859 |
MLK1 |
0.741 | -0.043 | 2 | 0.812 |
PDHK1 |
0.741 | -0.094 | 1 | 0.384 |
WNK1 |
0.741 | -0.026 | -2 | 0.838 |
PKN3 |
0.740 | -0.022 | -3 | 0.584 |
CAMK1B |
0.740 | -0.049 | -3 | 0.584 |
CLK2 |
0.740 | 0.251 | -3 | 0.529 |
PDHK4 |
0.739 | -0.143 | 1 | 0.387 |
CHAK2 |
0.739 | -0.042 | -1 | 0.747 |
MLK3 |
0.739 | 0.028 | 2 | 0.786 |
PRKD1 |
0.739 | 0.035 | -3 | 0.580 |
COT |
0.739 | -0.112 | 2 | 0.738 |
NUAK2 |
0.738 | -0.002 | -3 | 0.574 |
GCN2 |
0.738 | -0.149 | 2 | 0.767 |
NIK |
0.738 | -0.058 | -3 | 0.612 |
PKR |
0.738 | 0.039 | 1 | 0.333 |
IKKE |
0.737 | -0.109 | 1 | 0.301 |
IRE1 |
0.736 | -0.017 | 1 | 0.290 |
TGFBR2 |
0.735 | -0.072 | -2 | 0.671 |
DSTYK |
0.735 | -0.135 | 2 | 0.800 |
CAMLCK |
0.734 | -0.040 | -2 | 0.790 |
GRK5 |
0.734 | -0.128 | -3 | 0.615 |
ULK2 |
0.734 | -0.143 | 2 | 0.742 |
PKN2 |
0.734 | -0.030 | -3 | 0.575 |
RAF1 |
0.734 | -0.192 | 1 | 0.329 |
PIM3 |
0.733 | -0.080 | -3 | 0.593 |
PKCD |
0.733 | -0.004 | 2 | 0.786 |
PRKD2 |
0.732 | 0.008 | -3 | 0.524 |
NEK9 |
0.732 | -0.086 | 2 | 0.826 |
MLK2 |
0.732 | -0.066 | 2 | 0.798 |
CAMK2G |
0.732 | -0.114 | 2 | 0.685 |
VRK2 |
0.731 | 0.068 | 1 | 0.426 |
DAPK2 |
0.731 | -0.078 | -3 | 0.597 |
IKKB |
0.731 | -0.156 | -2 | 0.622 |
NEK7 |
0.731 | -0.151 | -3 | 0.561 |
PKCA |
0.730 | 0.031 | 2 | 0.779 |
PINK1 |
0.730 | 0.084 | 1 | 0.497 |
BMPR1B |
0.730 | -0.045 | 1 | 0.299 |
PRKD3 |
0.730 | 0.007 | -3 | 0.487 |
TSSK2 |
0.729 | -0.014 | -5 | 0.812 |
DLK |
0.729 | -0.169 | 1 | 0.337 |
RSK2 |
0.729 | -0.037 | -3 | 0.525 |
TSSK1 |
0.728 | -0.007 | -3 | 0.618 |
ANKRD3 |
0.728 | -0.137 | 1 | 0.345 |
YSK4 |
0.728 | -0.081 | 1 | 0.298 |
BCKDK |
0.728 | -0.103 | -1 | 0.699 |
PHKG1 |
0.727 | -0.036 | -3 | 0.573 |
WNK3 |
0.727 | -0.180 | 1 | 0.309 |
MNK2 |
0.727 | 0.008 | -2 | 0.766 |
NEK2 |
0.727 | -0.048 | 2 | 0.825 |
PIM1 |
0.727 | -0.033 | -3 | 0.539 |
MAPKAPK3 |
0.727 | -0.063 | -3 | 0.529 |
AMPKA1 |
0.726 | -0.076 | -3 | 0.591 |
RIPK3 |
0.726 | -0.113 | 3 | 0.584 |
ALK4 |
0.726 | -0.070 | -2 | 0.701 |
TTBK2 |
0.726 | -0.139 | 2 | 0.691 |
P90RSK |
0.726 | -0.043 | -3 | 0.543 |
PKCB |
0.725 | -0.000 | 2 | 0.782 |
MLK4 |
0.725 | -0.052 | 2 | 0.740 |
RSK3 |
0.725 | -0.053 | -3 | 0.534 |
SKMLCK |
0.725 | -0.081 | -2 | 0.809 |
IRE2 |
0.725 | -0.053 | 2 | 0.731 |
TGFBR1 |
0.725 | -0.057 | -2 | 0.667 |
HRI |
0.725 | -0.079 | -2 | 0.725 |
GRK6 |
0.725 | -0.141 | 1 | 0.341 |
AURC |
0.724 | 0.009 | -2 | 0.667 |
P70S6KB |
0.724 | -0.059 | -3 | 0.535 |
ACVR2A |
0.724 | -0.074 | -2 | 0.651 |
PKCZ |
0.724 | -0.017 | 2 | 0.788 |
HUNK |
0.724 | -0.149 | 2 | 0.720 |
CHAK1 |
0.724 | -0.099 | 2 | 0.767 |
PERK |
0.724 | -0.095 | -2 | 0.703 |
NDR2 |
0.724 | -0.075 | -3 | 0.586 |
GRK7 |
0.724 | -0.034 | 1 | 0.354 |
PKG2 |
0.723 | 0.009 | -2 | 0.705 |
SMG1 |
0.723 | -0.060 | 1 | 0.316 |
PKCG |
0.723 | -0.014 | 2 | 0.772 |
MEK1 |
0.723 | -0.157 | 2 | 0.748 |
MST3 |
0.723 | 0.029 | 2 | 0.844 |
GRK1 |
0.722 | -0.074 | -2 | 0.674 |
BUB1 |
0.722 | 0.117 | -5 | 0.801 |
ULK1 |
0.722 | -0.163 | -3 | 0.566 |
CAMK2D |
0.722 | -0.094 | -3 | 0.573 |
NDR1 |
0.722 | -0.102 | -3 | 0.578 |
PKCH |
0.722 | -0.032 | 2 | 0.767 |
MPSK1 |
0.721 | 0.027 | 1 | 0.361 |
PKACG |
0.721 | -0.047 | -2 | 0.743 |
AMPKA2 |
0.720 | -0.068 | -3 | 0.559 |
AKT2 |
0.720 | -0.009 | -3 | 0.454 |
MEKK2 |
0.720 | -0.041 | 2 | 0.777 |
MEKK1 |
0.720 | -0.073 | 1 | 0.338 |
MASTL |
0.720 | -0.222 | -2 | 0.716 |
ALK2 |
0.719 | -0.068 | -2 | 0.671 |
ACVR2B |
0.719 | -0.099 | -2 | 0.663 |
MAPKAPK2 |
0.719 | -0.055 | -3 | 0.497 |
CAMK4 |
0.719 | -0.111 | -3 | 0.547 |
GRK4 |
0.719 | -0.158 | -2 | 0.697 |
GSK3A |
0.719 | 0.137 | 4 | 0.276 |
NUAK1 |
0.719 | -0.053 | -3 | 0.522 |
RIPK1 |
0.719 | -0.168 | 1 | 0.291 |
EEF2K |
0.719 | 0.029 | 3 | 0.790 |
MARK4 |
0.719 | -0.109 | 4 | 0.766 |
ATM |
0.718 | -0.096 | 1 | 0.303 |
SGK3 |
0.718 | -0.034 | -3 | 0.525 |
MEK5 |
0.718 | -0.118 | 2 | 0.774 |
CK1E |
0.718 | -0.030 | -3 | 0.416 |
TAO3 |
0.717 | -0.017 | 1 | 0.339 |
IKKA |
0.717 | -0.120 | -2 | 0.607 |
WNK4 |
0.717 | -0.073 | -2 | 0.832 |
MNK1 |
0.717 | -0.026 | -2 | 0.772 |
PHKG2 |
0.717 | -0.044 | -3 | 0.530 |
PAK6 |
0.716 | -0.006 | -2 | 0.667 |
TAO2 |
0.716 | 0.003 | 2 | 0.823 |
AURB |
0.716 | -0.020 | -2 | 0.656 |
BMPR1A |
0.716 | -0.059 | 1 | 0.289 |
ZAK |
0.716 | -0.108 | 1 | 0.317 |
TLK2 |
0.716 | -0.113 | 1 | 0.284 |
PIM2 |
0.716 | -0.033 | -3 | 0.493 |
AURA |
0.714 | -0.014 | -2 | 0.609 |
MEKK3 |
0.714 | -0.119 | 1 | 0.316 |
IRAK4 |
0.714 | -0.080 | 1 | 0.279 |
CK1D |
0.714 | -0.015 | -3 | 0.372 |
MELK |
0.714 | -0.097 | -3 | 0.543 |
PLK1 |
0.714 | -0.144 | -2 | 0.689 |
PAK3 |
0.714 | -0.101 | -2 | 0.744 |
NEK5 |
0.713 | -0.089 | 1 | 0.304 |
PKCE |
0.713 | 0.022 | 2 | 0.778 |
CHK1 |
0.713 | -0.057 | -3 | 0.580 |
PKCI |
0.713 | -0.004 | 2 | 0.783 |
PAK1 |
0.712 | -0.087 | -2 | 0.758 |
LATS1 |
0.712 | -0.089 | -3 | 0.605 |
HGK |
0.711 | -0.007 | 3 | 0.814 |
PKCT |
0.711 | -0.037 | 2 | 0.770 |
TNIK |
0.711 | 0.007 | 3 | 0.828 |
DNAPK |
0.711 | -0.073 | 1 | 0.286 |
PKACB |
0.711 | -0.022 | -2 | 0.686 |
LATS2 |
0.710 | -0.108 | -5 | 0.614 |
MEKK6 |
0.710 | -0.055 | 1 | 0.310 |
NEK8 |
0.710 | -0.118 | 2 | 0.804 |
AKT1 |
0.710 | -0.027 | -3 | 0.470 |
GAK |
0.710 | -0.049 | 1 | 0.368 |
MSK2 |
0.709 | -0.091 | -3 | 0.508 |
MAPKAPK5 |
0.709 | -0.100 | -3 | 0.494 |
RSK4 |
0.709 | -0.058 | -3 | 0.502 |
QIK |
0.708 | -0.135 | -3 | 0.550 |
LKB1 |
0.708 | -0.019 | -3 | 0.632 |
TLK1 |
0.708 | -0.155 | -2 | 0.687 |
GRK2 |
0.708 | -0.113 | -2 | 0.594 |
PDK1 |
0.708 | -0.075 | 1 | 0.355 |
GCK |
0.707 | -0.040 | 1 | 0.306 |
CK1A2 |
0.707 | -0.036 | -3 | 0.370 |
MAP3K15 |
0.707 | -0.081 | 1 | 0.317 |
NIM1 |
0.707 | -0.151 | 3 | 0.660 |
MYLK4 |
0.707 | -0.080 | -2 | 0.724 |
MINK |
0.707 | -0.047 | 1 | 0.293 |
CAMK2A |
0.707 | -0.086 | 2 | 0.665 |
LRRK2 |
0.707 | -0.019 | 2 | 0.814 |
NEK11 |
0.706 | -0.125 | 1 | 0.336 |
CAMK2B |
0.706 | -0.103 | 2 | 0.623 |
PAK2 |
0.706 | -0.108 | -2 | 0.734 |
KHS1 |
0.706 | -0.002 | 1 | 0.308 |
MSK1 |
0.706 | -0.066 | -3 | 0.515 |
PKN1 |
0.706 | -0.027 | -3 | 0.475 |
QSK |
0.706 | -0.094 | 4 | 0.749 |
TTBK1 |
0.706 | -0.128 | 2 | 0.598 |
SMMLCK |
0.706 | -0.074 | -3 | 0.546 |
PLK3 |
0.705 | -0.144 | 2 | 0.628 |
CK1G1 |
0.705 | -0.062 | -3 | 0.414 |
HPK1 |
0.705 | -0.039 | 1 | 0.306 |
KHS2 |
0.704 | 0.020 | 1 | 0.310 |
SSTK |
0.704 | -0.060 | 4 | 0.759 |
LOK |
0.704 | -0.041 | -2 | 0.704 |
VRK1 |
0.704 | -0.065 | 2 | 0.746 |
PRKX |
0.703 | -0.011 | -3 | 0.456 |
DRAK1 |
0.703 | -0.169 | 1 | 0.259 |
NEK4 |
0.703 | -0.101 | 1 | 0.285 |
PKACA |
0.702 | -0.023 | -2 | 0.649 |
DCAMKL1 |
0.702 | -0.114 | -3 | 0.545 |
FAM20C |
0.702 | -0.059 | 2 | 0.423 |
YSK1 |
0.702 | -0.027 | 2 | 0.839 |
BRAF |
0.702 | -0.195 | -4 | 0.720 |
PASK |
0.702 | -0.102 | -3 | 0.595 |
CAMK1G |
0.702 | -0.095 | -3 | 0.497 |
MST2 |
0.702 | -0.096 | 1 | 0.315 |
SIK |
0.702 | -0.109 | -3 | 0.496 |
GSK3B |
0.701 | -0.006 | 4 | 0.264 |
P70S6K |
0.701 | -0.076 | -3 | 0.460 |
BRSK2 |
0.700 | -0.131 | -3 | 0.552 |
PLK4 |
0.700 | -0.158 | 2 | 0.577 |
DCAMKL2 |
0.700 | -0.105 | -3 | 0.542 |
TAK1 |
0.700 | -0.142 | 1 | 0.303 |
CHK2 |
0.700 | -0.040 | -3 | 0.416 |
AKT3 |
0.699 | -0.021 | -3 | 0.419 |
HASPIN |
0.699 | 0.010 | -1 | 0.578 |
CAMKK1 |
0.699 | -0.199 | -2 | 0.644 |
NEK1 |
0.699 | -0.078 | 1 | 0.288 |
NEK3 |
0.699 | -0.028 | 1 | 0.308 |
SNRK |
0.698 | -0.194 | 2 | 0.634 |
BRSK1 |
0.698 | -0.123 | -3 | 0.541 |
CK2A2 |
0.697 | -0.065 | 1 | 0.282 |
MYO3B |
0.697 | 0.028 | 2 | 0.835 |
MARK2 |
0.697 | -0.107 | 4 | 0.680 |
SLK |
0.697 | -0.075 | -2 | 0.640 |
SBK |
0.696 | 0.033 | -3 | 0.365 |
PBK |
0.696 | -0.061 | 1 | 0.335 |
MARK3 |
0.696 | -0.107 | 4 | 0.714 |
GRK3 |
0.696 | -0.106 | -2 | 0.550 |
CAMKK2 |
0.696 | -0.176 | -2 | 0.651 |
PAK5 |
0.695 | -0.048 | -2 | 0.610 |
SGK1 |
0.695 | -0.023 | -3 | 0.406 |
MRCKB |
0.695 | -0.042 | -3 | 0.483 |
OSR1 |
0.695 | -0.050 | 2 | 0.772 |
PKG1 |
0.694 | -0.011 | -2 | 0.654 |
MST1 |
0.694 | -0.104 | 1 | 0.300 |
TAO1 |
0.694 | 0.001 | 1 | 0.295 |
MEK2 |
0.692 | -0.187 | 2 | 0.754 |
ROCK2 |
0.691 | -0.055 | -3 | 0.543 |
CAMK1A |
0.691 | -0.046 | -3 | 0.419 |
CAMK1D |
0.690 | -0.087 | -3 | 0.443 |
MARK1 |
0.690 | -0.145 | 4 | 0.736 |
IRAK1 |
0.690 | -0.224 | -1 | 0.692 |
DAPK3 |
0.690 | -0.101 | -3 | 0.545 |
MRCKA |
0.689 | -0.066 | -3 | 0.499 |
BIKE |
0.689 | -0.026 | 1 | 0.332 |
MYO3A |
0.688 | -0.036 | 1 | 0.298 |
RIPK2 |
0.688 | -0.185 | 1 | 0.301 |
PAK4 |
0.688 | -0.044 | -2 | 0.612 |
PLK2 |
0.688 | -0.090 | -3 | 0.610 |
TTK |
0.688 | -0.078 | -2 | 0.703 |
CK2A1 |
0.687 | -0.075 | 1 | 0.265 |
ASK1 |
0.685 | -0.117 | 1 | 0.324 |
DMPK1 |
0.684 | -0.036 | -3 | 0.501 |
DAPK1 |
0.683 | -0.100 | -3 | 0.532 |
STK33 |
0.682 | -0.148 | 2 | 0.569 |
AAK1 |
0.681 | 0.006 | 1 | 0.310 |
ROCK1 |
0.681 | -0.059 | -3 | 0.509 |
CRIK |
0.678 | -0.045 | -3 | 0.464 |
ALPHAK3 |
0.673 | -0.125 | -1 | 0.722 |
STLK3 |
0.671 | -0.157 | 1 | 0.296 |
CK1A |
0.670 | -0.059 | -3 | 0.312 |
CK1G3 |
0.668 | -0.046 | -3 | 0.274 |
YANK3 |
0.667 | -0.081 | 2 | 0.327 |
PDHK3_TYR |
0.663 | 0.087 | 4 | 0.801 |
TESK1_TYR |
0.660 | 0.022 | 3 | 0.792 |
LIMK2_TYR |
0.659 | 0.097 | -3 | 0.629 |
PKMYT1_TYR |
0.657 | 0.057 | 3 | 0.730 |
MAP2K4_TYR |
0.656 | -0.042 | -1 | 0.798 |
TNNI3K_TYR |
0.655 | 0.063 | 1 | 0.385 |
MAP2K7_TYR |
0.655 | -0.053 | 2 | 0.770 |
PINK1_TYR |
0.653 | -0.114 | 1 | 0.382 |
PDHK1_TYR |
0.653 | -0.056 | -1 | 0.826 |
PDHK4_TYR |
0.651 | -0.024 | 2 | 0.741 |
MAP2K6_TYR |
0.651 | -0.068 | -1 | 0.796 |
LIMK1_TYR |
0.651 | -0.017 | 2 | 0.796 |
JAK2 |
0.650 | -0.049 | 1 | 0.364 |
RET |
0.650 | -0.085 | 1 | 0.348 |
TYK2 |
0.650 | -0.098 | 1 | 0.346 |
BMPR2_TYR |
0.650 | -0.041 | -1 | 0.790 |
MST1R |
0.650 | -0.051 | 3 | 0.683 |
ROS1 |
0.647 | -0.075 | 3 | 0.663 |
CSF1R |
0.647 | -0.066 | 3 | 0.652 |
EPHA6 |
0.644 | -0.102 | -1 | 0.826 |
TYRO3 |
0.644 | -0.112 | 3 | 0.700 |
FGR |
0.644 | -0.102 | 1 | 0.331 |
JAK1 |
0.644 | -0.030 | 1 | 0.314 |
LCK |
0.643 | -0.045 | -1 | 0.831 |
EPHB4 |
0.642 | -0.111 | -1 | 0.816 |
TXK |
0.642 | -0.066 | 1 | 0.317 |
HCK |
0.642 | -0.075 | -1 | 0.824 |
ABL2 |
0.640 | -0.082 | -1 | 0.782 |
YES1 |
0.640 | -0.076 | -1 | 0.835 |
FER |
0.640 | -0.133 | 1 | 0.353 |
JAK3 |
0.640 | -0.119 | 1 | 0.332 |
ABL1 |
0.640 | -0.072 | -1 | 0.781 |
CK1G2 |
0.639 | -0.068 | -3 | 0.349 |
BLK |
0.638 | -0.059 | -1 | 0.830 |
WEE1_TYR |
0.637 | -0.033 | -1 | 0.701 |
NEK10_TYR |
0.637 | -0.097 | 1 | 0.279 |
YANK2 |
0.636 | -0.102 | 2 | 0.337 |
DDR1 |
0.636 | -0.155 | 4 | 0.767 |
FGFR2 |
0.635 | -0.084 | 3 | 0.648 |
FLT3 |
0.635 | -0.135 | 3 | 0.680 |
TNK1 |
0.635 | -0.072 | 3 | 0.666 |
KIT |
0.635 | -0.122 | 3 | 0.656 |
ITK |
0.635 | -0.104 | -1 | 0.780 |
FGFR1 |
0.634 | -0.072 | 3 | 0.620 |
PDGFRA |
0.634 | -0.135 | 3 | 0.680 |
EPHB1 |
0.633 | -0.137 | 1 | 0.339 |
PDGFRB |
0.633 | -0.164 | 3 | 0.677 |
EPHB3 |
0.632 | -0.128 | -1 | 0.807 |
EPHA4 |
0.632 | -0.109 | 2 | 0.614 |
FYN |
0.632 | -0.066 | -1 | 0.817 |
MET |
0.631 | -0.108 | 3 | 0.647 |
FRK |
0.631 | -0.095 | -1 | 0.827 |
KDR |
0.630 | -0.110 | 3 | 0.596 |
SRMS |
0.630 | -0.147 | 1 | 0.332 |
EPHB2 |
0.630 | -0.135 | -1 | 0.817 |
TEK |
0.630 | -0.080 | 3 | 0.618 |
TEC |
0.630 | -0.111 | -1 | 0.746 |
BTK |
0.630 | -0.154 | -1 | 0.747 |
BMX |
0.629 | -0.093 | -1 | 0.720 |
ALK |
0.629 | -0.127 | 3 | 0.570 |
INSRR |
0.628 | -0.171 | 3 | 0.613 |
MERTK |
0.627 | -0.119 | 3 | 0.630 |
PTK6 |
0.627 | -0.155 | -1 | 0.711 |
AXL |
0.627 | -0.139 | 3 | 0.636 |
LYN |
0.625 | -0.107 | 3 | 0.562 |
EPHA1 |
0.625 | -0.122 | 3 | 0.627 |
ERBB2 |
0.625 | -0.137 | 1 | 0.328 |
FLT1 |
0.625 | -0.130 | -1 | 0.782 |
TNK2 |
0.625 | -0.146 | 3 | 0.598 |
EGFR |
0.625 | -0.079 | 1 | 0.303 |
EPHA7 |
0.624 | -0.125 | 2 | 0.634 |
SRC |
0.624 | -0.090 | -1 | 0.814 |
LTK |
0.623 | -0.145 | 3 | 0.583 |
PTK2B |
0.622 | -0.089 | -1 | 0.796 |
EPHA3 |
0.621 | -0.137 | 2 | 0.608 |
MUSK |
0.621 | -0.084 | 1 | 0.283 |
FGFR3 |
0.621 | -0.123 | 3 | 0.613 |
NTRK2 |
0.621 | -0.190 | 3 | 0.603 |
MATK |
0.620 | -0.106 | -1 | 0.706 |
NTRK3 |
0.620 | -0.137 | -1 | 0.736 |
NTRK1 |
0.619 | -0.201 | -1 | 0.778 |
FLT4 |
0.619 | -0.163 | 3 | 0.592 |
CSK |
0.618 | -0.120 | 2 | 0.640 |
SYK |
0.617 | -0.077 | -1 | 0.749 |
EPHA8 |
0.617 | -0.124 | -1 | 0.778 |
INSR |
0.616 | -0.175 | 3 | 0.598 |
FGFR4 |
0.616 | -0.104 | -1 | 0.752 |
PTK2 |
0.615 | -0.071 | -1 | 0.750 |
EPHA5 |
0.613 | -0.153 | 2 | 0.594 |
DDR2 |
0.612 | -0.104 | 3 | 0.574 |
EPHA2 |
0.606 | -0.132 | -1 | 0.752 |
ERBB4 |
0.606 | -0.097 | 1 | 0.311 |
IGF1R |
0.605 | -0.147 | 3 | 0.535 |
ZAP70 |
0.601 | -0.064 | -1 | 0.659 |
FES |
0.593 | -0.140 | -1 | 0.707 |