Motif 365 (n=212)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S88 | ochoa | Golgin A8 family member Q | None |
| A1L170 | C1orf226 | S196 | ochoa | Uncharacterized protein C1orf226 | None |
| A3KN83 | SBNO1 | S904 | ochoa | Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) | Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250|UniProtKB:Q689Z5}. |
| A6NKT7 | RGPD3 | S978 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MT19 | RHPN2P1 | S549 | ochoa | Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1) | None |
| I6L899 | GOLGA8R | S88 | ochoa | Golgin subfamily A member 8R | None |
| O00763 | ACACB | S35 | ochoa | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}. |
| O14492 | SH2B2 | S115 | ochoa | SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}. |
| O14492 | SH2B2 | S330 | ochoa | SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}. |
| O14523 | C2CD2L | S660 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14715 | RGPD8 | S977 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14776 | TCERG1 | S833 | ochoa | Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) | Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}. |
| O15085 | ARHGEF11 | S547 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15117 | FYB1 | S182 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O43159 | RRP8 | S124 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O43399 | TPD52L2 | S19 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43933 | PEX1 | S1209 | ochoa | Peroxisomal ATPase PEX1 (EC 3.6.4.-) (Peroxin-1) (Peroxisome biogenesis disorder protein 1) (Peroxisome biogenesis factor 1) | Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:11439091, PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772). {ECO:0000269|PubMed:11439091, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118, ECO:0000269|PubMed:29884772}. |
| O60271 | SPAG9 | S183 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60292 | SIPA1L3 | S1617 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60346 | PHLPP1 | S1379 | psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60832 | DKC1 | S451 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O60832 | DKC1 | S453 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O75369 | FLNB | S1382 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O94880 | PHF14 | S296 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95049 | TJP3 | S369 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95071 | UBR5 | S2484 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95630 | STAMBP | S243 | psp | STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). {ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699, ECO:0000269|PubMed:34425109}. |
| O95831 | AIFM1 | S116 | ochoa|psp | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| O95999 | BCL10 | S134 | ochoa|psp | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| P01275 | GCG | S34 | ochoa | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] | [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
| P04279 | SEMG1 | S290 | ochoa | Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein] | Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. {ECO:0000269|PubMed:19889947}.; FUNCTION: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. {ECO:0000269|PubMed:19889947}. |
| P06213 | INSR | S1062 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P06241 | FYN | S188 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P07947 | YES1 | S197 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P09769 | FGR | S183 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0DJD0 | RGPD1 | S962 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S970 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P13611 | VCAN | S1349 | ochoa | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) | May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. |
| P13667 | PDIA4 | S468 | ochoa | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P16070 | CD44 | S704 | ochoa|psp | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P17181 | IFNAR1 | S493 | ochoa | Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) | Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461, PubMed:21854986, PubMed:24075985, PubMed:31270247, PubMed:33252644, PubMed:35442418, PubMed:7813427). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:21854986, PubMed:7665574). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (PubMed:21854986, PubMed:32972995, PubMed:7526154, PubMed:7665574, PubMed:7813427). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:19561067, PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427, PubMed:9121453). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:31270247, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33252644, ECO:0000269|PubMed:35442418, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:9121453}. |
| P17600 | SYN1 | S341 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P21333 | FLNA | S1409 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S1921 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2081 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P25205 | MCM3 | S275 | ochoa | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P27797 | CALR | S193 | ochoa | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P30622 | CLIP1 | S195 | ochoa|psp | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P31689 | DNAJA1 | S112 | ochoa | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}. |
| P35221 | CTNNA1 | S295 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P46100 | ATRX | S729 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P47736 | RAP1GAP | S456 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49792 | RANBP2 | S1953 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51813 | BMX | S251 | ochoa | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
| P52597 | HNRNPF | S21 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P52701 | MSH6 | S252 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P53004 | BLVRA | S235 | ochoa | Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}. |
| P55317 | FOXA1 | S221 | ochoa | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}. |
| P55318 | FOXA3 | S168 | ochoa | Hepatocyte nuclear factor 3-gamma (HNF-3-gamma) (HNF-3G) (Fork head-related protein FKH H3) (Forkhead box protein A3) (Transcription factor 3G) (TCF-3G) | Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. {ECO:0000250, ECO:0000269|PubMed:12695546}. |
| P55957 | BID | S76 | ochoa|psp | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| P62857 | RPS28 | S39 | ochoa | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}. |
| P69891 | HBG1 | S51 | ochoa | Hemoglobin subunit gamma-1 (Gamma-1-globin) (Hb F Agamma) (Hemoglobin gamma-1 chain) (Hemoglobin gamma-A chain) | Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. {ECO:0000269|PubMed:11514664, ECO:0000269|PubMed:22096240, ECO:0000269|PubMed:6198905}. |
| P69892 | HBG2 | S51 | ochoa | Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain) | Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. {ECO:0000269|PubMed:19065339, ECO:0000269|PubMed:21561349, ECO:0000269|PubMed:24502349}. |
| Q01105 | SET | S166 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01804 | OTUD4 | S349 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q01831 | XPC | S397 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q02383 | SEMG2 | S350 | ochoa | Semenogelin-2 (Semenogelin II) (SGII) | Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. |
| Q03164 | KMT2A | S1056 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07666 | KHDRBS1 | S388 | psp | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q08378 | GOLGA3 | S393 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12888 | TP53BP1 | S784 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13422 | IKZF1 | S296 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13480 | GAB1 | S206 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13905 | RAPGEF1 | S251 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14202 | ZMYM3 | S1045 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14324 | MYBPC2 | S60 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14324 | MYBPC2 | S112 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14678 | KANK1 | S879 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q15043 | SLC39A14 | S309 | ochoa | Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) | Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185). {ECO:0000250|UniProtKB:Q75N73, ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:20682781, ECO:0000269|PubMed:23052185, ECO:0000269|PubMed:27231142, ECO:0000269|PubMed:27703010, ECO:0000269|PubMed:29621230, ECO:0000269|PubMed:31028174, ECO:0000269|PubMed:31699897}. |
| Q15554 | TERF2 | S410 | ochoa | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). {ECO:0000250|UniProtKB:O35144, ECO:0000269|PubMed:15608617, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:9326950, ECO:0000269|PubMed:9326951, ECO:0000269|PubMed:9476899}. |
| Q15678 | PTPN14 | S807 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q15758 | SLC1A5 | S491 | ochoa | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}. |
| Q16706 | MAN2A1 | S80 | ochoa | Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}. |
| Q29RF7 | PDS5A | S1159 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q32MZ4 | LRRFIP1 | S66 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q32MZ4 | LRRFIP1 | S766 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q4KMP7 | TBC1D10B | S316 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q5JQS6 | GCSAML | S62 | ochoa | Germinal center-associated signaling and motility-like protein | None |
| Q5SSJ5 | HP1BP3 | S225 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5TCY1 | TTBK1 | S515 | ochoa | Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase) | Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. {ECO:0000269|PubMed:16923168}. |
| Q5VZ89 | DENND4C | S1064 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q641Q2 | WASHC2A | S158 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q641Q2 | WASHC2A | S1142 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q659C4 | LARP1B | S361 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q6DN90 | IQSEC1 | S923 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6IQ55 | TTBK2 | S1101 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6PJP8 | DCLRE1A | S641 | ochoa | DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A) | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15542852}. |
| Q6PKG0 | LARP1 | S546 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6RI45 | BRWD3 | S1577 | ochoa | Bromodomain and WD repeat-containing protein 3 | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}. |
| Q6UB98 | ANKRD12 | S1141 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6ZU65 | UBN2 | S631 | ochoa | Ubinuclein-2 | None |
| Q6ZV73 | FGD6 | S605 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7Z3J3 | RGPD4 | S978 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z422 | SZRD1 | S105 | ochoa | SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) | None |
| Q7Z5L9 | IRF2BP2 | S381 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z6Z7 | HUWE1 | S1368 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S2370 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UE4 | MTDH | S214 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86WP2 | GPBP1 | S379 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q86YN6 | PPARGC1B | S992 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Q8IUC4 | RHPN2 | S652 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8IWZ3 | ANKHD1 | S93 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IZT6 | ASPM | S605 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8IZT6 | ASPM | S1103 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N0T1 | RBIS | S67 | ochoa | Ribosomal biogenesis factor | Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. {ECO:0000269|PubMed:26711351}. |
| Q8N3X1 | FNBP4 | S659 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8N573 | OXR1 | S202 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N6H7 | ARFGAP2 | S240 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8N7R7 | CCNYL1 | S93 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
| Q8N884 | CGAS | S263 | psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8NAA4 | ATG16L2 | S276 | ochoa | Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) | May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. {ECO:0000250|UniProtKB:Q6KAU8}. |
| Q8NBJ4 | GOLM1 | S307 | ochoa | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | Unknown. Cellular response protein to viral infection. |
| Q8ND30 | PPFIBP2 | S385 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8ND76 | CCNY | S71 | ochoa|psp | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NEJ9 | NGDN | S202 | ochoa | Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9DB96, ECO:0000269|PubMed:34516797}. |
| Q8NFC6 | BOD1L1 | Y2777 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NI08 | NCOA7 | S209 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8NI27 | THOC2 | S1448 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TAA9 | VANGL1 | S86 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TC07 | TBC1D15 | S203 | ochoa | TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) | Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}. |
| Q8TDD1 | DDX54 | S696 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8TEW0 | PARD3 | S152 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TEW0 | PARD3 | S971 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF62 | ATP8B4 | S1166 | ochoa | Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) | Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}. |
| Q8TF72 | SHROOM3 | S1219 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WW22 | DNAJA4 | S113 | ochoa | DnaJ homolog subfamily A member 4 | None |
| Q92619 | ARHGAP45 | S623 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92628 | KIAA0232 | S1078 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q92777 | SYN2 | S341 | ochoa | Synapsin-2 (Synapsin II) | Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). {ECO:0000250}. |
| Q96E17 | RAB3C | S196 | ochoa | Ras-related protein Rab-3C (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P10949}. |
| Q96MU7 | YTHDC1 | S120 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96PY5 | FMNL2 | S169 | ochoa | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96Q15 | SMG1 | S1917 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96Q45 | TMEM237 | S47 | ochoa | Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein) | Component of the transition zone in primary cilia. Required for ciliogenesis. {ECO:0000269|PubMed:22152675}. |
| Q96Q89 | KIF20B | S1586 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96RT1 | ERBIN | S850 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96RV3 | PCNX1 | S323 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96RV3 | PCNX1 | S483 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96T23 | RSF1 | S227 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T37 | RBM15 | S208 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96T58 | SPEN | S1380 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99666 | RGPD5 | S977 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BVJ6 | UTP14A | S29 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BW71 | HIRIP3 | S330 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BXF6 | RAB11FIP5 | S174 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BYI3 | HYCC1 | S451 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
| Q9BZ71 | PITPNM3 | S319 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
| Q9GZY6 | LAT2 | Y84 | psp | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H410 | DSN1 | S39 | ochoa | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9H582 | ZNF644 | S197 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H582 | ZNF644 | S1138 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H792 | PEAK1 | S212 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7D0 | DOCK5 | S1740 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9H7D7 | WDR26 | S121 | ochoa | WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2) | G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:26895380, PubMed:27098453). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Also protects cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity). {ECO:0000250|UniProtKB:F1LTR1, ECO:0000269|PubMed:15378603, ECO:0000269|PubMed:19446606, ECO:0000269|PubMed:23625927, ECO:0000269|PubMed:26895380, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:29911972}. |
| Q9HAC8 | UBTD1 | S164 | ochoa | Ubiquitin domain-containing protein 1 | May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. {ECO:0000269|PubMed:25382750}. |
| Q9HC44 | GPBP1L1 | S382 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9HC77 | CPAP | S681 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HCG8 | CWC22 | S864 | ochoa | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q9HCH5 | SYTL2 | S509 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCK8 | CHD8 | S1540 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NPI1 | BRD7 | S263 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NQT8 | KIF13B | S1389 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NR45 | NANS | S251 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
| Q9NS56 | TOPORS | S864 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NSI6 | BRWD1 | S1605 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NSI6 | BRWD1 | S1786 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NSY1 | BMP2K | S947 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NTI5 | PDS5B | S1257 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NWQ8 | PAG1 | S50 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NXV6 | CDKN2AIP | S131 | ochoa | CDKN2A-interacting protein (Collaborator of ARF) | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}. |
| Q9NY61 | AATF | S61 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NYV4 | CDK12 | S30 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P2D6 | FAM135A | S705 | ochoa | Protein FAM135A | None |
| Q9P2N5 | RBM27 | S1020 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9P2T1 | GMPR2 | S26 | ochoa | GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). {ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469}. |
| Q9UGU0 | TCF20 | S1370 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHB6 | LIMA1 | S228 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9ULJ3 | ZBTB21 | S223 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULK5 | VANGL2 | S82 | ochoa | Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2) | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}. |
| Q9ULU4 | ZMYND8 | S1102 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULU4 | ZMYND8 | S1124 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMD9 | COL17A1 | S542 | psp | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UMZ2 | SYNRG | S467 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UN79 | SOX13 | S96 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UQB8 | BAIAP2 | S259 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y297 | BTRC | S127 | ochoa | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14603323, PubMed:14681206). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:9859996). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:10835356, PubMed:11158290, PubMed:14673179). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564, PubMed:25704143). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:18354482, PubMed:21258371). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:33110214, PubMed:36608670). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265). {ECO:0000250|UniProtKB:Q3ULA2, ECO:0000269|PubMed:10066435, ECO:0000269|PubMed:10497169, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:11238952, ECO:0000269|PubMed:11359933, ECO:0000269|PubMed:11994270, ECO:0000269|PubMed:12077367, ECO:0000269|PubMed:12791267, ECO:0000269|PubMed:12820959, ECO:0000269|PubMed:12902344, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988407, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:18354482, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:38225265, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990852}. |
| Q9Y2J2 | EPB41L3 | S871 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y3S1 | WNK2 | S1150 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y426 | C2CD2 | S647 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y487 | ATP6V0A2 | S157 | ochoa | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}. |
| Q9Y520 | PRRC2C | S876 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5W7 | SNX14 | S485 | ochoa | Sorting nexin-14 | Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25148684, PubMed:25848753). {ECO:0000250|UniProtKB:Q8BHY8, ECO:0000269|PubMed:25148684, ECO:0000269|PubMed:25848753, ECO:0000305|PubMed:25848753}. |
| O00444 | PLK4 | S441 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| O00116 | AGPS | S174 | Sugiyama | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
| P16070 | CD44 | S71 | Sugiyama | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P27797 | CALR | S78 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| O15111 | CHUK | S400 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P17948 | FLT1 | S1205 | Sugiyama | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| Q9Y3S2 | ZNF330 | S25 | Sugiyama | Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein) | None |
| Q7Z4S6 | KIF21A | S708 | Sugiyama | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| P31946 | YWHAB | S145 | Sugiyama | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| Q9BYP7 | WNK3 | S47 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.000001 | 5.924 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.000375 | 3.426 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.002014 | 2.696 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.026835 | 1.571 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.026835 | 1.571 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.026835 | 1.571 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.026835 | 1.571 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.026835 | 1.571 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.026835 | 1.571 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.039982 | 1.398 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.039982 | 1.398 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.052953 | 1.276 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.052953 | 1.276 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.052953 | 1.276 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.052953 | 1.276 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.052953 | 1.276 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.052953 | 1.276 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.052953 | 1.276 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.052953 | 1.276 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.052953 | 1.276 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.052953 | 1.276 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.052953 | 1.276 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.052953 | 1.276 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.008419 | 2.075 |
| R-HSA-8865999 | MET activates PTPN11 | 0.065749 | 1.182 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.013854 | 1.858 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.013854 | 1.858 |
| R-HSA-74713 | IRS activation | 0.090827 | 1.042 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.090827 | 1.042 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 0.090827 | 1.042 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.103114 | 0.987 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.115235 | 0.938 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 0.115235 | 0.938 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 0.115235 | 0.938 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.127194 | 0.896 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.127194 | 0.896 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 0.127194 | 0.896 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.127194 | 0.896 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.138991 | 0.857 |
| R-HSA-8875656 | MET receptor recycling | 0.138991 | 0.857 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.138991 | 0.857 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.138991 | 0.857 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.138991 | 0.857 |
| R-HSA-180292 | GAB1 signalosome | 0.039710 | 1.401 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.056339 | 1.249 |
| R-HSA-2022923 | DS-GAG biosynthesis | 0.184615 | 0.734 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.184615 | 0.734 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.195639 | 0.709 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.031513 | 1.502 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.078858 | 1.103 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.217245 | 0.663 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.227831 | 0.642 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.227831 | 0.642 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.248576 | 0.605 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.248576 | 0.605 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.258740 | 0.587 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.258740 | 0.587 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.134791 | 0.870 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.278658 | 0.555 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.288417 | 0.540 |
| R-HSA-2022870 | CS-GAG biosynthesis | 0.307541 | 0.512 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.316911 | 0.499 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.344269 | 0.463 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.137459 | 0.862 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.137459 | 0.862 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.361899 | 0.441 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.361899 | 0.441 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.231549 | 0.635 |
| R-HSA-191859 | snRNP Assembly | 0.231549 | 0.635 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.251559 | 0.599 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.251559 | 0.599 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.387463 | 0.412 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.266599 | 0.574 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.395756 | 0.403 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.395756 | 0.403 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.412008 | 0.385 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.412008 | 0.385 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.301648 | 0.520 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.301648 | 0.520 |
| R-HSA-380287 | Centrosome maturation | 0.311621 | 0.506 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.346253 | 0.461 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.380302 | 0.420 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.329501 | 0.482 |
| R-HSA-72172 | mRNA Splicing | 0.363229 | 0.440 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.223929 | 0.650 |
| R-HSA-157579 | Telomere Maintenance | 0.182916 | 0.738 |
| R-HSA-3928664 | Ephrin signaling | 0.268767 | 0.571 |
| R-HSA-180786 | Extension of Telomeres | 0.231549 | 0.635 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.353144 | 0.452 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.153225 | 0.815 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.387463 | 0.412 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.130220 | 0.885 |
| R-HSA-73886 | Chromosome Maintenance | 0.113752 | 0.944 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.138991 | 0.857 |
| R-HSA-77387 | Insulin receptor recycling | 0.078858 | 1.103 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.206516 | 0.685 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.316911 | 0.499 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.107966 | 0.967 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.074932 | 1.125 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.227831 | 0.642 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.238274 | 0.623 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.248576 | 0.605 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.096724 | 1.014 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.316911 | 0.499 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.241544 | 0.617 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.258740 | 0.587 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 0.026835 | 1.571 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.138991 | 0.857 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.227831 | 0.642 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.344269 | 0.463 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.056339 | 1.249 |
| R-HSA-170968 | Frs2-mediated activation | 0.022869 | 1.641 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.038379 | 1.416 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.090827 | 1.042 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.028067 | 1.552 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.047450 | 1.324 |
| R-HSA-2424491 | DAP12 signaling | 0.387463 | 0.412 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.082558 | 1.083 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.378416 | 0.422 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.004498 | 2.347 |
| R-HSA-525793 | Myogenesis | 0.071073 | 1.148 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.195639 | 0.709 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.193136 | 0.714 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.139398 | 0.856 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.162904 | 0.788 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.172496 | 0.763 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.238274 | 0.623 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.414806 | 0.382 |
| R-HSA-373753 | Nephrin family interactions | 0.288417 | 0.540 |
| R-HSA-169893 | Prolonged ERK activation events | 0.030827 | 1.511 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 0.026835 | 1.571 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.039982 | 1.398 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.052953 | 1.276 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.018121 | 1.742 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.103114 | 0.987 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.025413 | 1.595 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.039710 | 1.401 |
| R-HSA-176974 | Unwinding of DNA | 0.150630 | 0.822 |
| R-HSA-75896 | Plasmalogen biosynthesis | 0.184615 | 0.734 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.195639 | 0.709 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.206516 | 0.685 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.082846 | 1.082 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.086894 | 1.061 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.217245 | 0.663 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.227831 | 0.642 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.227831 | 0.642 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.335273 | 0.475 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.131318 | 0.882 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.413588 | 0.383 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.033118 | 1.480 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.082846 | 1.082 |
| R-HSA-68877 | Mitotic Prometaphase | 0.027042 | 1.568 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.177327 | 0.751 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.162947 | 0.788 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.039710 | 1.401 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.148711 | 0.828 |
| R-HSA-202424 | Downstream TCR signaling | 0.153225 | 0.815 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.221581 | 0.654 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.090827 | 1.042 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.258740 | 0.587 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.268767 | 0.571 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.404164 | 0.393 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.179542 | 0.746 |
| R-HSA-8875878 | MET promotes cell motility | 0.125687 | 0.901 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.082846 | 1.082 |
| R-HSA-5358508 | Mismatch Repair | 0.268767 | 0.571 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.341382 | 0.467 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.138991 | 0.857 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.046103 | 1.336 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.162112 | 0.790 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.056339 | 1.249 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.091372 | 1.039 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.335273 | 0.475 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.403937 | 0.394 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.403937 | 0.394 |
| R-HSA-373755 | Semaphorin interactions | 0.251559 | 0.599 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.379057 | 0.421 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.104389 | 0.981 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.059528 | 1.225 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.385108 | 0.414 |
| R-HSA-9033241 | Peroxisomal protein import | 0.231549 | 0.635 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.144038 | 0.842 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.065749 | 1.182 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.103114 | 0.987 |
| R-HSA-170984 | ARMS-mediated activation | 0.150630 | 0.822 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.150630 | 0.822 |
| R-HSA-1483226 | Synthesis of PI | 0.173439 | 0.761 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.227831 | 0.642 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.227831 | 0.642 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.268767 | 0.571 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.278658 | 0.555 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.206702 | 0.685 |
| R-HSA-420029 | Tight junction interactions | 0.344269 | 0.463 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.353144 | 0.452 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.256571 | 0.591 |
| R-HSA-187687 | Signalling to ERKs | 0.112330 | 0.950 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.259979 | 0.585 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.335273 | 0.475 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.379057 | 0.421 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.387463 | 0.412 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.137028 | 0.863 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.167242 | 0.777 |
| R-HSA-9664407 | Parasite infection | 0.167242 | 0.777 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.167242 | 0.777 |
| R-HSA-8953854 | Metabolism of RNA | 0.025484 | 1.594 |
| R-HSA-202403 | TCR signaling | 0.026558 | 1.576 |
| R-HSA-392517 | Rap1 signalling | 0.042862 | 1.368 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.150630 | 0.822 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.022769 | 1.643 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.288417 | 0.540 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.216611 | 0.664 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.361899 | 0.441 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.276627 | 0.558 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.286194 | 0.543 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.056339 | 1.249 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.112330 | 0.950 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.186813 | 0.729 |
| R-HSA-6806834 | Signaling by MET | 0.336409 | 0.473 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.078373 | 1.106 |
| R-HSA-8866376 | Reelin signalling pathway | 0.090827 | 1.042 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.103114 | 0.987 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.195639 | 0.709 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.195639 | 0.709 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.206516 | 0.685 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.227831 | 0.642 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.316911 | 0.499 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.251559 | 0.599 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.306638 | 0.513 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.412008 | 0.385 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.014490 | 1.839 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.074932 | 1.125 |
| R-HSA-9659379 | Sensory processing of sound | 0.331470 | 0.480 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.361899 | 0.441 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.144361 | 0.841 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.412008 | 0.385 |
| R-HSA-177929 | Signaling by EGFR | 0.216611 | 0.664 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.336409 | 0.473 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.217245 | 0.663 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.412008 | 0.385 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.306638 | 0.513 |
| R-HSA-8853659 | RET signaling | 0.116740 | 0.933 |
| R-HSA-69481 | G2/M Checkpoints | 0.304623 | 0.516 |
| R-HSA-68886 | M Phase | 0.185766 | 0.731 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.216611 | 0.664 |
| R-HSA-1640170 | Cell Cycle | 0.041972 | 1.377 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.196843 | 0.706 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.018121 | 1.742 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.103114 | 0.987 |
| R-HSA-164944 | Nef and signal transduction | 0.115235 | 0.938 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.173439 | 0.761 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.173439 | 0.761 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.206516 | 0.685 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.217245 | 0.663 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.227831 | 0.642 |
| R-HSA-9930044 | Nuclear RNA decay | 0.099381 | 1.003 |
| R-HSA-8848584 | Wax and plasmalogen biosynthesis | 0.288417 | 0.540 |
| R-HSA-200425 | Carnitine shuttle | 0.326154 | 0.487 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.361899 | 0.441 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.403937 | 0.394 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.228137 | 0.642 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.202346 | 0.694 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.067281 | 1.172 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.158145 | 0.801 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.296653 | 0.528 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.289874 | 0.538 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.268767 | 0.571 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.027734 | 1.557 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.103114 | 0.987 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.238274 | 0.623 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.258740 | 0.587 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.258740 | 0.587 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.258740 | 0.587 |
| R-HSA-2160916 | Hyaluronan degradation | 0.344269 | 0.463 |
| R-HSA-2029481 | FCGR activation | 0.166228 | 0.779 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.268904 | 0.570 |
| R-HSA-913531 | Interferon Signaling | 0.312057 | 0.506 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.087315 | 1.059 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.086894 | 1.061 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.219239 | 0.659 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.015926 | 1.798 |
| R-HSA-435354 | Zinc transporters | 0.217245 | 0.663 |
| R-HSA-196780 | Biotin transport and metabolism | 0.227831 | 0.642 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.344269 | 0.463 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.412008 | 0.385 |
| R-HSA-1500931 | Cell-Cell communication | 0.175977 | 0.755 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.344269 | 0.463 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.344269 | 0.463 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.054497 | 1.264 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.175142 | 0.757 |
| R-HSA-69242 | S Phase | 0.393040 | 0.406 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.278916 | 0.555 |
| R-HSA-210990 | PECAM1 interactions | 0.015926 | 1.798 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.103114 | 0.987 |
| R-HSA-74749 | Signal attenuation | 0.162112 | 0.790 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.227831 | 0.642 |
| R-HSA-983189 | Kinesins | 0.066615 | 1.176 |
| R-HSA-8854214 | TBC/RABGAPs | 0.153413 | 0.814 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 0.316911 | 0.499 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.353144 | 0.452 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.361899 | 0.441 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.379057 | 0.421 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.387463 | 0.412 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.091372 | 1.039 |
| R-HSA-194138 | Signaling by VEGF | 0.125159 | 0.903 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.276627 | 0.558 |
| R-HSA-69190 | DNA strand elongation | 0.403937 | 0.394 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.298044 | 0.526 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.298044 | 0.526 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.256935 | 0.590 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.298044 | 0.526 |
| R-HSA-450294 | MAP kinase activation | 0.241544 | 0.617 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.311621 | 0.506 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.179945 | 0.745 |
| R-HSA-446728 | Cell junction organization | 0.381565 | 0.418 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.301648 | 0.520 |
| R-HSA-166520 | Signaling by NTRKs | 0.191312 | 0.718 |
| R-HSA-448424 | Interleukin-17 signaling | 0.286647 | 0.543 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.351158 | 0.454 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.150630 | 0.822 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.195639 | 0.709 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.389897 | 0.409 |
| R-HSA-162582 | Signal Transduction | 0.295949 | 0.529 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.031513 | 1.502 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.278658 | 0.555 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.022869 | 1.641 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.217245 | 0.663 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.227831 | 0.642 |
| R-HSA-210991 | Basigin interactions | 0.298044 | 0.526 |
| R-HSA-9766229 | Degradation of CDH1 | 0.182178 | 0.740 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.300931 | 0.522 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.361899 | 0.441 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.267864 | 0.572 |
| R-HSA-68882 | Mitotic Anaphase | 0.220048 | 0.657 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.335273 | 0.475 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.387463 | 0.412 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.360928 | 0.443 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.222490 | 0.653 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.321716 | 0.493 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.231549 | 0.635 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.264215 | 0.578 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.082846 | 1.082 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.307541 | 0.512 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.370536 | 0.431 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.395756 | 0.403 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.271613 | 0.566 |
| R-HSA-163685 | Integration of energy metabolism | 0.345283 | 0.462 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.074932 | 1.125 |
| R-HSA-983712 | Ion channel transport | 0.314222 | 0.503 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.086894 | 1.061 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.316911 | 0.499 |
| R-HSA-8983711 | OAS antiviral response | 0.195639 | 0.709 |
| R-HSA-186763 | Downstream signal transduction | 0.395756 | 0.403 |
| R-HSA-109582 | Hemostasis | 0.084428 | 1.074 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.090827 | 1.042 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.207933 | 0.682 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.326154 | 0.487 |
| R-HSA-449147 | Signaling by Interleukins | 0.265994 | 0.575 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.132871 | 0.877 |
| R-HSA-73887 | Death Receptor Signaling | 0.414806 | 0.382 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.326154 | 0.487 |
| R-HSA-168268 | Virus Assembly and Release | 0.238274 | 0.623 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.251559 | 0.599 |
| R-HSA-186712 | Regulation of beta-cell development | 0.231549 | 0.635 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.331470 | 0.480 |
| R-HSA-2028269 | Signaling by Hippo | 0.258740 | 0.587 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.311621 | 0.506 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.261584 | 0.582 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.403937 | 0.394 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.316596 | 0.499 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.375481 | 0.425 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.419970 | 0.377 |
| R-HSA-390522 | Striated Muscle Contraction | 0.419970 | 0.377 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.419970 | 0.377 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.419970 | 0.377 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.419970 | 0.377 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.419970 | 0.377 |
| R-HSA-2024101 | CS/DS degradation | 0.419970 | 0.377 |
| R-HSA-189483 | Heme degradation | 0.419970 | 0.377 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.427004 | 0.370 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.427583 | 0.369 |
| R-HSA-5673000 | RAF activation | 0.427824 | 0.369 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.427824 | 0.369 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.427824 | 0.369 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.427824 | 0.369 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.427824 | 0.369 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.427824 | 0.369 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.427824 | 0.369 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.427824 | 0.369 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.427824 | 0.369 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.427824 | 0.369 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.435573 | 0.361 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.435573 | 0.361 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.435573 | 0.361 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.435573 | 0.361 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.435573 | 0.361 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.435573 | 0.361 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.436816 | 0.360 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.436816 | 0.360 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.436816 | 0.360 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.436816 | 0.360 |
| R-HSA-190236 | Signaling by FGFR | 0.436816 | 0.360 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.441403 | 0.355 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.443217 | 0.353 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.443217 | 0.353 |
| R-HSA-109581 | Apoptosis | 0.443430 | 0.353 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.450514 | 0.346 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.450758 | 0.346 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.450758 | 0.346 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.450758 | 0.346 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.450758 | 0.346 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.450758 | 0.346 |
| R-HSA-8948216 | Collagen chain trimerization | 0.450758 | 0.346 |
| R-HSA-73927 | Depurination | 0.458198 | 0.339 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.458198 | 0.339 |
| R-HSA-74217 | Purine salvage | 0.458198 | 0.339 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.463188 | 0.334 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.464022 | 0.333 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.465537 | 0.332 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.465537 | 0.332 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.465537 | 0.332 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.465537 | 0.332 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.472777 | 0.325 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.472777 | 0.325 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.472777 | 0.325 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.472777 | 0.325 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.472777 | 0.325 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.472777 | 0.325 |
| R-HSA-5260271 | Diseases of Immune System | 0.472777 | 0.325 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.472777 | 0.325 |
| R-HSA-202433 | Generation of second messenger molecules | 0.472777 | 0.325 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 0.472777 | 0.325 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.472918 | 0.325 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.477333 | 0.321 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.479920 | 0.319 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.479920 | 0.319 |
| R-HSA-9694548 | Maturation of spike protein | 0.479920 | 0.319 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.479920 | 0.319 |
| R-HSA-9607240 | FLT3 Signaling | 0.479920 | 0.319 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.485294 | 0.314 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.485294 | 0.314 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.486096 | 0.313 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.486096 | 0.313 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.486096 | 0.313 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.486966 | 0.313 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.486966 | 0.313 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.486966 | 0.313 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.486966 | 0.313 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.486966 | 0.313 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.486966 | 0.313 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.486966 | 0.313 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.486966 | 0.313 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.486966 | 0.313 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.486966 | 0.313 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.490443 | 0.309 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.493917 | 0.306 |
| R-HSA-165159 | MTOR signalling | 0.493917 | 0.306 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.493917 | 0.306 |
| R-HSA-73928 | Depyrimidination | 0.493917 | 0.306 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.494767 | 0.306 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.494767 | 0.306 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.500775 | 0.300 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.503346 | 0.298 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.503346 | 0.298 |
| R-HSA-168255 | Influenza Infection | 0.505660 | 0.296 |
| R-HSA-2172127 | DAP12 interactions | 0.507540 | 0.295 |
| R-HSA-373752 | Netrin-1 signaling | 0.507540 | 0.295 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.507600 | 0.294 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.511830 | 0.291 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.514214 | 0.289 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.514214 | 0.289 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.514214 | 0.289 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.514214 | 0.289 |
| R-HSA-774815 | Nucleosome assembly | 0.514214 | 0.289 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.514214 | 0.289 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.514214 | 0.289 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.514214 | 0.289 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.514214 | 0.289 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.514214 | 0.289 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.516036 | 0.287 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.518320 | 0.285 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.519005 | 0.285 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.520219 | 0.284 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.520797 | 0.283 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.520797 | 0.283 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.520797 | 0.283 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.520797 | 0.283 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.520797 | 0.283 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.520797 | 0.283 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.520797 | 0.283 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.520797 | 0.283 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.520797 | 0.283 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.520797 | 0.283 |
| R-HSA-9675135 | Diseases of DNA repair | 0.520797 | 0.283 |
| R-HSA-75153 | Apoptotic execution phase | 0.520797 | 0.283 |
| R-HSA-9679506 | SARS-CoV Infections | 0.525740 | 0.279 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.527292 | 0.278 |
| R-HSA-69275 | G2/M Transition | 0.528886 | 0.277 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.532622 | 0.274 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.533699 | 0.273 |
| R-HSA-425410 | Metal ion SLC transporters | 0.533699 | 0.273 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.535411 | 0.271 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.535411 | 0.271 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.540020 | 0.268 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.540768 | 0.267 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.540768 | 0.267 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.540768 | 0.267 |
| R-HSA-5617833 | Cilium Assembly | 0.541885 | 0.266 |
| R-HSA-68875 | Mitotic Prophase | 0.544805 | 0.264 |
| R-HSA-109704 | PI3K Cascade | 0.546256 | 0.263 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.546256 | 0.263 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.547797 | 0.261 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.552804 | 0.257 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.552804 | 0.257 |
| R-HSA-72187 | mRNA 3'-end processing | 0.558475 | 0.253 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.558475 | 0.253 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.558475 | 0.253 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.558475 | 0.253 |
| R-HSA-199991 | Membrane Trafficking | 0.560280 | 0.252 |
| R-HSA-1221632 | Meiotic synapsis | 0.564462 | 0.248 |
| R-HSA-72649 | Translation initiation complex formation | 0.570367 | 0.244 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.570367 | 0.244 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.576193 | 0.239 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.576193 | 0.239 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.580017 | 0.237 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.581940 | 0.235 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.581940 | 0.235 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.581940 | 0.235 |
| R-HSA-75893 | TNF signaling | 0.581940 | 0.235 |
| R-HSA-9658195 | Leishmania infection | 0.586565 | 0.232 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.586565 | 0.232 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.587610 | 0.231 |
| R-HSA-112399 | IRS-mediated signalling | 0.587610 | 0.231 |
| R-HSA-5621480 | Dectin-2 family | 0.587610 | 0.231 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.587610 | 0.231 |
| R-HSA-73894 | DNA Repair | 0.590835 | 0.229 |
| R-HSA-5357801 | Programmed Cell Death | 0.591752 | 0.228 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.593203 | 0.227 |
| R-HSA-1280218 | Adaptive Immune System | 0.593889 | 0.226 |
| R-HSA-168256 | Immune System | 0.597410 | 0.224 |
| R-HSA-9909396 | Circadian clock | 0.598703 | 0.223 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.598703 | 0.223 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.598721 | 0.223 |
| R-HSA-4085001 | Sialic acid metabolism | 0.598721 | 0.223 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.598721 | 0.223 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.604164 | 0.219 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.609533 | 0.215 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.609533 | 0.215 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.609533 | 0.215 |
| R-HSA-8956321 | Nucleotide salvage | 0.609533 | 0.215 |
| R-HSA-1442490 | Collagen degradation | 0.609533 | 0.215 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.614830 | 0.211 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.614830 | 0.211 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.614830 | 0.211 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.614830 | 0.211 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.614830 | 0.211 |
| R-HSA-186797 | Signaling by PDGF | 0.614830 | 0.211 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.614830 | 0.211 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.616761 | 0.210 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.620056 | 0.208 |
| R-HSA-8848021 | Signaling by PTK6 | 0.620056 | 0.208 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.620056 | 0.208 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.625211 | 0.204 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.625211 | 0.204 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.625211 | 0.204 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.627294 | 0.203 |
| R-HSA-195721 | Signaling by WNT | 0.629645 | 0.201 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.630296 | 0.200 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.630296 | 0.200 |
| R-HSA-6798695 | Neutrophil degranulation | 0.634364 | 0.198 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.635313 | 0.197 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.640262 | 0.194 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.644572 | 0.191 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.645144 | 0.190 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.645144 | 0.190 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.650184 | 0.187 |
| R-HSA-422475 | Axon guidance | 0.652304 | 0.186 |
| R-HSA-162906 | HIV Infection | 0.654382 | 0.184 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.654711 | 0.184 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.659398 | 0.181 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.659398 | 0.181 |
| R-HSA-3000178 | ECM proteoglycans | 0.659398 | 0.181 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.659398 | 0.181 |
| R-HSA-189445 | Metabolism of porphyrins | 0.659398 | 0.181 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.660787 | 0.180 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.664021 | 0.178 |
| R-HSA-168249 | Innate Immune System | 0.664932 | 0.177 |
| R-HSA-72312 | rRNA processing | 0.667622 | 0.175 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.668582 | 0.175 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.668582 | 0.175 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.673082 | 0.172 |
| R-HSA-9609507 | Protein localization | 0.676612 | 0.170 |
| R-HSA-8852135 | Protein ubiquitination | 0.677520 | 0.169 |
| R-HSA-917937 | Iron uptake and transport | 0.677520 | 0.169 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.680991 | 0.167 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.682772 | 0.166 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.686218 | 0.164 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.687595 | 0.163 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.690479 | 0.161 |
| R-HSA-4086400 | PCP/CE pathway | 0.690479 | 0.161 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.690479 | 0.161 |
| R-HSA-216083 | Integrin cell surface interactions | 0.690479 | 0.161 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.694715 | 0.158 |
| R-HSA-877300 | Interferon gamma signaling | 0.694806 | 0.158 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.698829 | 0.156 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.698829 | 0.156 |
| R-HSA-9833482 | PKR-mediated signaling | 0.698829 | 0.156 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.702920 | 0.153 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.702920 | 0.153 |
| R-HSA-977225 | Amyloid fiber formation | 0.702920 | 0.153 |
| R-HSA-4839726 | Chromatin organization | 0.709865 | 0.149 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.710936 | 0.148 |
| R-HSA-421270 | Cell-cell junction organization | 0.714555 | 0.146 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.714862 | 0.146 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.714862 | 0.146 |
| R-HSA-9675108 | Nervous system development | 0.715401 | 0.145 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.718736 | 0.143 |
| R-HSA-1500620 | Meiosis | 0.718736 | 0.143 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.722557 | 0.141 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.722557 | 0.141 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.728666 | 0.137 |
| R-HSA-70268 | Pyruvate metabolism | 0.730046 | 0.137 |
| R-HSA-156902 | Peptide chain elongation | 0.733714 | 0.134 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.733991 | 0.134 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.736620 | 0.133 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.736620 | 0.133 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.740903 | 0.130 |
| R-HSA-73884 | Base Excision Repair | 0.740903 | 0.130 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.741812 | 0.130 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.744424 | 0.128 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.747898 | 0.126 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.751325 | 0.124 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.751325 | 0.124 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.754705 | 0.122 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.754705 | 0.122 |
| R-HSA-1474290 | Collagen formation | 0.758040 | 0.120 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.761329 | 0.118 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.761329 | 0.118 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.764574 | 0.117 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.764574 | 0.117 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.767776 | 0.115 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.770933 | 0.113 |
| R-HSA-422356 | Regulation of insulin secretion | 0.774048 | 0.111 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.777121 | 0.110 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.779948 | 0.108 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.780153 | 0.108 |
| R-HSA-70171 | Glycolysis | 0.780153 | 0.108 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.780282 | 0.108 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.783143 | 0.106 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.784722 | 0.105 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.786093 | 0.105 |
| R-HSA-1483255 | PI Metabolism | 0.786093 | 0.105 |
| R-HSA-192823 | Viral mRNA Translation | 0.789002 | 0.103 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.791234 | 0.102 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.791873 | 0.101 |
| R-HSA-9833110 | RSV-host interactions | 0.794704 | 0.100 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.797497 | 0.098 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.799648 | 0.097 |
| R-HSA-418346 | Platelet homeostasis | 0.800253 | 0.097 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.802971 | 0.095 |
| R-HSA-69239 | Synthesis of DNA | 0.802971 | 0.095 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.802971 | 0.095 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.802971 | 0.095 |
| R-HSA-211000 | Gene Silencing by RNA | 0.802971 | 0.095 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.803742 | 0.095 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.805652 | 0.094 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.805652 | 0.094 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.808297 | 0.092 |
| R-HSA-6803157 | Antimicrobial peptides | 0.813480 | 0.090 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.816019 | 0.088 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.820993 | 0.086 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.825834 | 0.083 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.826784 | 0.083 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.828206 | 0.082 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.830545 | 0.081 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.830545 | 0.081 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.832853 | 0.079 |
| R-HSA-70326 | Glucose metabolism | 0.832853 | 0.079 |
| R-HSA-5693538 | Homology Directed Repair | 0.835129 | 0.078 |
| R-HSA-418990 | Adherens junctions interactions | 0.835648 | 0.078 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.841774 | 0.075 |
| R-HSA-3371556 | Cellular response to heat stress | 0.841774 | 0.075 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.852262 | 0.069 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.852262 | 0.069 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.852262 | 0.069 |
| R-HSA-69206 | G1/S Transition | 0.852262 | 0.069 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.854691 | 0.068 |
| R-HSA-114608 | Platelet degranulation | 0.856261 | 0.067 |
| R-HSA-1474244 | Extracellular matrix organization | 0.857865 | 0.067 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.861333 | 0.065 |
| R-HSA-1474165 | Reproduction | 0.863939 | 0.064 |
| R-HSA-8939211 | ESR-mediated signaling | 0.865722 | 0.063 |
| R-HSA-9843745 | Adipogenesis | 0.865793 | 0.063 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.865793 | 0.063 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.869427 | 0.061 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.876404 | 0.057 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.878090 | 0.056 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.879752 | 0.056 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.879752 | 0.056 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.884606 | 0.053 |
| R-HSA-1632852 | Macroautophagy | 0.884606 | 0.053 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.887733 | 0.052 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.893736 | 0.049 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.895186 | 0.048 |
| R-HSA-9758941 | Gastrulation | 0.898027 | 0.047 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.899419 | 0.046 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.899419 | 0.046 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.899419 | 0.046 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.900792 | 0.045 |
| R-HSA-112316 | Neuronal System | 0.901622 | 0.045 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.902146 | 0.045 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.902146 | 0.045 |
| R-HSA-69306 | DNA Replication | 0.903482 | 0.044 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.903482 | 0.044 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.904170 | 0.044 |
| R-HSA-1266738 | Developmental Biology | 0.905468 | 0.043 |
| R-HSA-1989781 | PPARA activates gene expression | 0.906100 | 0.043 |
| R-HSA-9612973 | Autophagy | 0.907382 | 0.042 |
| R-HSA-9610379 | HCMV Late Events | 0.908646 | 0.042 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.908646 | 0.042 |
| R-HSA-162587 | HIV Life Cycle | 0.908646 | 0.042 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.908646 | 0.042 |
| R-HSA-9711097 | Cellular response to starvation | 0.909894 | 0.041 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.910315 | 0.041 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.912338 | 0.040 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.912338 | 0.040 |
| R-HSA-9824446 | Viral Infection Pathways | 0.916380 | 0.038 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.917031 | 0.038 |
| R-HSA-5619102 | SLC transporter disorders | 0.920385 | 0.036 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.924107 | 0.034 |
| R-HSA-72306 | tRNA processing | 0.924649 | 0.034 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.925026 | 0.034 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.925325 | 0.034 |
| R-HSA-418555 | G alpha (s) signalling events | 0.925679 | 0.034 |
| R-HSA-1483257 | Phospholipid metabolism | 0.929045 | 0.032 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.929838 | 0.032 |
| R-HSA-2559583 | Cellular Senescence | 0.934339 | 0.029 |
| R-HSA-3781865 | Diseases of glycosylation | 0.937858 | 0.028 |
| R-HSA-9609690 | HCMV Early Events | 0.947329 | 0.023 |
| R-HSA-2262752 | Cellular responses to stress | 0.947502 | 0.023 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.948344 | 0.023 |
| R-HSA-8957322 | Metabolism of steroids | 0.948931 | 0.023 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.952174 | 0.021 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.952174 | 0.021 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.958250 | 0.019 |
| R-HSA-397014 | Muscle contraction | 0.958337 | 0.018 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.960813 | 0.017 |
| R-HSA-8951664 | Neddylation | 0.963204 | 0.016 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.965659 | 0.015 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.967053 | 0.015 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.967468 | 0.014 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.967505 | 0.014 |
| R-HSA-15869 | Metabolism of nucleotides | 0.970090 | 0.013 |
| R-HSA-157118 | Signaling by NOTCH | 0.971699 | 0.012 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.974309 | 0.011 |
| R-HSA-9609646 | HCMV Infection | 0.975353 | 0.011 |
| R-HSA-5688426 | Deubiquitination | 0.977001 | 0.010 |
| R-HSA-416476 | G alpha (q) signalling events | 0.979694 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 0.984647 | 0.007 |
| R-HSA-597592 | Post-translational protein modification | 0.985639 | 0.006 |
| R-HSA-5663205 | Infectious disease | 0.988597 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.993025 | 0.003 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.994936 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997259 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.997928 | 0.001 |
| R-HSA-72766 | Translation | 0.997985 | 0.001 |
| R-HSA-74160 | Gene expression (Transcription) | 0.998725 | 0.001 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.998973 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999195 | 0.000 |
| R-HSA-212436 | Generic Transcription Pathway | 0.999458 | 0.000 |
| R-HSA-1643685 | Disease | 0.999463 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999788 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999811 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999859 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999937 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999974 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.776 | 0.169 | 2 | 0.267 |
SKMLCK |
0.768 | 0.188 | -2 | 0.886 |
FAM20C |
0.767 | 0.024 | 2 | 0.180 |
PIM3 |
0.766 | 0.106 | -3 | 0.856 |
NDR2 |
0.764 | 0.073 | -3 | 0.863 |
CLK3 |
0.764 | 0.170 | 1 | 0.802 |
RSK2 |
0.761 | 0.102 | -3 | 0.813 |
CDC7 |
0.761 | 0.002 | 1 | 0.830 |
NDR1 |
0.758 | 0.082 | -3 | 0.866 |
PIM1 |
0.758 | 0.114 | -3 | 0.818 |
CAMK2G |
0.758 | 0.052 | 2 | 0.231 |
CAMK1B |
0.757 | 0.079 | -3 | 0.893 |
RIPK3 |
0.755 | 0.086 | 3 | 0.795 |
P90RSK |
0.755 | 0.074 | -3 | 0.806 |
WNK1 |
0.755 | 0.076 | -2 | 0.911 |
CAMK2B |
0.755 | 0.092 | 2 | 0.237 |
RAF1 |
0.754 | 0.094 | 1 | 0.805 |
MOS |
0.754 | 0.027 | 1 | 0.863 |
RSK4 |
0.753 | 0.111 | -3 | 0.782 |
MARK4 |
0.753 | 0.024 | 4 | 0.581 |
CLK2 |
0.753 | 0.213 | -3 | 0.795 |
HUNK |
0.753 | 0.070 | 2 | 0.272 |
IKKB |
0.753 | 0.030 | -2 | 0.785 |
PRPK |
0.752 | 0.003 | -1 | 0.793 |
NUAK2 |
0.752 | 0.065 | -3 | 0.877 |
ERK5 |
0.752 | 0.064 | 1 | 0.823 |
PAK1 |
0.751 | 0.065 | -2 | 0.800 |
LATS2 |
0.751 | 0.038 | -5 | 0.622 |
DSTYK |
0.750 | 0.049 | 2 | 0.281 |
GRK6 |
0.750 | 0.087 | 1 | 0.818 |
CAMK2A |
0.749 | 0.085 | 2 | 0.270 |
CAMLCK |
0.749 | 0.080 | -2 | 0.869 |
MYLK4 |
0.749 | 0.128 | -2 | 0.783 |
P70S6KB |
0.749 | 0.067 | -3 | 0.843 |
CDKL1 |
0.749 | 0.038 | -3 | 0.828 |
CDKL5 |
0.749 | 0.041 | -3 | 0.820 |
GRK1 |
0.748 | 0.050 | -2 | 0.822 |
RSK3 |
0.748 | 0.047 | -3 | 0.806 |
MSK1 |
0.748 | 0.108 | -3 | 0.785 |
PKN2 |
0.748 | 0.040 | -3 | 0.880 |
PRKD1 |
0.747 | 0.008 | -3 | 0.834 |
NIM1 |
0.747 | -0.002 | 3 | 0.798 |
CAMK2D |
0.747 | 0.026 | -3 | 0.860 |
PRKD2 |
0.747 | 0.039 | -3 | 0.806 |
GCN2 |
0.746 | -0.118 | 2 | 0.206 |
MST4 |
0.746 | 0.006 | 2 | 0.220 |
PKACG |
0.746 | 0.051 | -2 | 0.748 |
TSSK2 |
0.746 | 0.008 | -5 | 0.678 |
AMPKA1 |
0.746 | 0.001 | -3 | 0.885 |
DAPK2 |
0.745 | 0.060 | -3 | 0.891 |
ATR |
0.745 | 0.003 | 1 | 0.825 |
TBK1 |
0.745 | -0.046 | 1 | 0.681 |
MTOR |
0.745 | 0.016 | 1 | 0.713 |
PKN3 |
0.745 | -0.008 | -3 | 0.852 |
MARK3 |
0.745 | 0.054 | 4 | 0.534 |
ULK2 |
0.744 | -0.129 | 2 | 0.180 |
PDHK4 |
0.744 | -0.112 | 1 | 0.804 |
BRSK1 |
0.744 | 0.014 | -3 | 0.834 |
CHAK2 |
0.744 | -0.010 | -1 | 0.832 |
NIK |
0.743 | 0.013 | -3 | 0.901 |
MAPKAPK2 |
0.743 | 0.058 | -3 | 0.764 |
AURC |
0.743 | 0.053 | -2 | 0.664 |
NLK |
0.743 | -0.029 | 1 | 0.761 |
PAK3 |
0.743 | 0.024 | -2 | 0.800 |
ATM |
0.743 | 0.056 | 1 | 0.764 |
PKCD |
0.743 | -0.004 | 2 | 0.191 |
GRK5 |
0.743 | -0.048 | -3 | 0.856 |
WNK3 |
0.742 | -0.066 | 1 | 0.787 |
SRPK1 |
0.742 | 0.056 | -3 | 0.785 |
DRAK1 |
0.742 | 0.185 | 1 | 0.737 |
IKKE |
0.742 | -0.035 | 1 | 0.677 |
BMPR2 |
0.742 | -0.064 | -2 | 0.905 |
TSSK1 |
0.741 | -0.013 | -3 | 0.897 |
RIPK1 |
0.741 | -0.000 | 1 | 0.802 |
MSK2 |
0.741 | 0.052 | -3 | 0.768 |
MLK1 |
0.740 | -0.083 | 2 | 0.220 |
PKACB |
0.740 | 0.087 | -2 | 0.677 |
MAPKAPK3 |
0.740 | 0.016 | -3 | 0.808 |
BMPR1B |
0.740 | 0.115 | 1 | 0.796 |
AMPKA2 |
0.740 | 0.001 | -3 | 0.864 |
PRKX |
0.739 | 0.096 | -3 | 0.752 |
IKKA |
0.739 | -0.001 | -2 | 0.778 |
PAK2 |
0.739 | 0.028 | -2 | 0.786 |
QSK |
0.739 | 0.007 | 4 | 0.551 |
TTBK2 |
0.739 | -0.091 | 2 | 0.168 |
PKCB |
0.739 | -0.006 | 2 | 0.187 |
PDHK1 |
0.739 | -0.149 | 1 | 0.797 |
MASTL |
0.739 | -0.066 | -2 | 0.859 |
MNK2 |
0.739 | 0.025 | -2 | 0.813 |
CAMK4 |
0.738 | 0.012 | -3 | 0.863 |
BRSK2 |
0.738 | -0.015 | -3 | 0.854 |
PLK3 |
0.738 | 0.067 | 2 | 0.271 |
LATS1 |
0.737 | 0.069 | -3 | 0.865 |
MELK |
0.737 | 0.001 | -3 | 0.852 |
MNK1 |
0.737 | 0.041 | -2 | 0.819 |
PKCG |
0.737 | -0.013 | 2 | 0.199 |
QIK |
0.737 | -0.015 | -3 | 0.871 |
CLK4 |
0.737 | 0.097 | -3 | 0.818 |
IRE1 |
0.737 | -0.081 | 1 | 0.822 |
BCKDK |
0.737 | -0.086 | -1 | 0.752 |
MARK2 |
0.737 | 0.000 | 4 | 0.516 |
HIPK4 |
0.737 | -0.024 | 1 | 0.761 |
CAMK1G |
0.736 | 0.057 | -3 | 0.805 |
ULK1 |
0.736 | -0.116 | -3 | 0.788 |
PIM2 |
0.736 | 0.083 | -3 | 0.799 |
GRK4 |
0.736 | -0.028 | -2 | 0.846 |
DYRK4 |
0.736 | 0.118 | 1 | 0.558 |
MARK1 |
0.736 | 0.023 | 4 | 0.548 |
PAK6 |
0.735 | 0.027 | -2 | 0.725 |
AURB |
0.735 | 0.040 | -2 | 0.663 |
NEK7 |
0.735 | -0.119 | -3 | 0.816 |
DNAPK |
0.735 | 0.086 | 1 | 0.666 |
TGFBR2 |
0.734 | -0.070 | -2 | 0.794 |
SGK3 |
0.734 | 0.048 | -3 | 0.817 |
SIK |
0.734 | 0.000 | -3 | 0.814 |
TGFBR1 |
0.734 | 0.057 | -2 | 0.799 |
DYRK2 |
0.734 | 0.044 | 1 | 0.651 |
SMG1 |
0.734 | 0.054 | 1 | 0.781 |
PLK1 |
0.734 | 0.010 | -2 | 0.818 |
ICK |
0.734 | -0.002 | -3 | 0.851 |
CLK1 |
0.733 | 0.086 | -3 | 0.803 |
PKCA |
0.733 | -0.034 | 2 | 0.176 |
SNRK |
0.733 | -0.064 | 2 | 0.183 |
DLK |
0.733 | 0.004 | 1 | 0.793 |
MLK3 |
0.733 | -0.069 | 2 | 0.190 |
PASK |
0.733 | 0.179 | -3 | 0.863 |
JNK2 |
0.732 | 0.074 | 1 | 0.527 |
NEK6 |
0.732 | -0.126 | -2 | 0.882 |
ANKRD3 |
0.732 | -0.082 | 1 | 0.831 |
KIS |
0.732 | -0.011 | 1 | 0.627 |
PLK4 |
0.732 | -0.053 | 2 | 0.163 |
DCAMKL1 |
0.731 | 0.046 | -3 | 0.833 |
PKCH |
0.731 | -0.038 | 2 | 0.178 |
NEK9 |
0.731 | -0.108 | 2 | 0.194 |
ALK2 |
0.731 | 0.091 | -2 | 0.807 |
PRKD3 |
0.731 | 0.006 | -3 | 0.795 |
NUAK1 |
0.731 | -0.024 | -3 | 0.838 |
PKR |
0.731 | -0.020 | 1 | 0.855 |
IRE2 |
0.730 | -0.083 | 2 | 0.162 |
ALK4 |
0.730 | 0.019 | -2 | 0.830 |
MLK2 |
0.730 | -0.112 | 2 | 0.196 |
PKCZ |
0.730 | -0.037 | 2 | 0.186 |
SRPK2 |
0.730 | 0.028 | -3 | 0.715 |
PKG2 |
0.729 | 0.027 | -2 | 0.675 |
AURA |
0.729 | 0.043 | -2 | 0.639 |
DCAMKL2 |
0.729 | 0.029 | -3 | 0.857 |
MEK1 |
0.727 | -0.018 | 2 | 0.246 |
GRK7 |
0.727 | 0.032 | 1 | 0.742 |
SSTK |
0.726 | -0.034 | 4 | 0.533 |
JNK3 |
0.726 | 0.041 | 1 | 0.570 |
AKT2 |
0.726 | 0.048 | -3 | 0.746 |
BMPR1A |
0.725 | 0.087 | 1 | 0.769 |
SMMLCK |
0.725 | 0.069 | -3 | 0.856 |
PKACA |
0.725 | 0.060 | -2 | 0.625 |
MLK4 |
0.725 | -0.099 | 2 | 0.181 |
CHAK1 |
0.724 | -0.106 | 2 | 0.170 |
CK2A2 |
0.723 | 0.089 | 1 | 0.726 |
ACVR2B |
0.723 | 0.038 | -2 | 0.802 |
PHKG1 |
0.723 | -0.077 | -3 | 0.857 |
MEKK3 |
0.723 | 0.018 | 1 | 0.767 |
CHK1 |
0.723 | -0.019 | -3 | 0.850 |
YSK4 |
0.723 | -0.038 | 1 | 0.728 |
WNK4 |
0.723 | -0.043 | -2 | 0.908 |
SRPK3 |
0.722 | 0.009 | -3 | 0.759 |
NEK2 |
0.722 | -0.088 | 2 | 0.190 |
VRK2 |
0.722 | -0.133 | 1 | 0.841 |
TTBK1 |
0.721 | -0.079 | 2 | 0.155 |
ACVR2A |
0.721 | 0.005 | -2 | 0.791 |
GSK3B |
0.721 | -0.007 | 4 | 0.366 |
IRAK4 |
0.721 | -0.062 | 1 | 0.811 |
CAMK1D |
0.721 | 0.041 | -3 | 0.739 |
MRCKA |
0.721 | 0.117 | -3 | 0.809 |
GSK3A |
0.720 | 0.003 | 4 | 0.381 |
P70S6K |
0.720 | 0.010 | -3 | 0.763 |
ERK7 |
0.720 | -0.025 | 2 | 0.145 |
GAK |
0.720 | 0.153 | 1 | 0.852 |
CDK7 |
0.719 | -0.042 | 1 | 0.598 |
DAPK3 |
0.719 | 0.070 | -3 | 0.842 |
CK2A1 |
0.719 | 0.091 | 1 | 0.703 |
P38A |
0.719 | 0.008 | 1 | 0.656 |
MST3 |
0.719 | 0.022 | 2 | 0.257 |
DAPK1 |
0.719 | 0.083 | -3 | 0.827 |
TLK2 |
0.719 | -0.086 | 1 | 0.795 |
GRK2 |
0.718 | -0.009 | -2 | 0.726 |
PKCT |
0.717 | -0.045 | 2 | 0.167 |
P38B |
0.717 | 0.016 | 1 | 0.585 |
CDK8 |
0.717 | -0.061 | 1 | 0.580 |
PHKG2 |
0.716 | -0.041 | -3 | 0.863 |
DYRK3 |
0.716 | 0.043 | 1 | 0.674 |
HIPK1 |
0.716 | -0.005 | 1 | 0.665 |
MRCKB |
0.715 | 0.081 | -3 | 0.803 |
PAK5 |
0.715 | 0.006 | -2 | 0.670 |
MAPKAPK5 |
0.715 | -0.040 | -3 | 0.743 |
PAK4 |
0.715 | 0.001 | -2 | 0.675 |
CK1E |
0.715 | -0.019 | -3 | 0.523 |
DYRK1A |
0.714 | -0.006 | 1 | 0.663 |
PKCI |
0.714 | -0.035 | 2 | 0.183 |
PKCE |
0.714 | -0.010 | 2 | 0.190 |
CDK18 |
0.714 | -0.025 | 1 | 0.533 |
BRAF |
0.714 | -0.045 | -4 | 0.808 |
DYRK1B |
0.713 | 0.015 | 1 | 0.590 |
AKT1 |
0.713 | 0.022 | -3 | 0.766 |
MEK5 |
0.713 | -0.130 | 2 | 0.221 |
PLK2 |
0.713 | 0.032 | -3 | 0.746 |
ERK2 |
0.713 | -0.035 | 1 | 0.597 |
NEK5 |
0.713 | -0.064 | 1 | 0.825 |
CDK1 |
0.712 | -0.013 | 1 | 0.560 |
PERK |
0.712 | -0.135 | -2 | 0.847 |
STK33 |
0.712 | -0.033 | 2 | 0.184 |
ROCK2 |
0.712 | 0.078 | -3 | 0.838 |
P38G |
0.712 | -0.007 | 1 | 0.463 |
ZAK |
0.712 | -0.107 | 1 | 0.736 |
SGK1 |
0.712 | 0.058 | -3 | 0.667 |
HIPK2 |
0.712 | -0.013 | 1 | 0.551 |
MEKK2 |
0.711 | -0.113 | 2 | 0.194 |
CDK14 |
0.711 | -0.009 | 1 | 0.573 |
CDK19 |
0.711 | -0.057 | 1 | 0.538 |
ERK1 |
0.710 | -0.030 | 1 | 0.559 |
YANK3 |
0.709 | -0.027 | 2 | 0.149 |
TLK1 |
0.709 | -0.091 | -2 | 0.837 |
MPSK1 |
0.709 | -0.031 | 1 | 0.814 |
CDK5 |
0.709 | -0.057 | 1 | 0.626 |
CDK10 |
0.709 | 0.002 | 1 | 0.560 |
CDK13 |
0.708 | -0.059 | 1 | 0.565 |
HRI |
0.708 | -0.147 | -2 | 0.860 |
IRAK1 |
0.708 | -0.126 | -1 | 0.731 |
MEKK1 |
0.707 | -0.162 | 1 | 0.779 |
CDK9 |
0.707 | -0.048 | 1 | 0.570 |
CDK17 |
0.707 | -0.034 | 1 | 0.475 |
NEK11 |
0.707 | -0.051 | 1 | 0.742 |
DMPK1 |
0.706 | 0.111 | -3 | 0.819 |
JNK1 |
0.706 | 0.031 | 1 | 0.521 |
PRP4 |
0.706 | -0.025 | -3 | 0.758 |
CDK2 |
0.706 | -0.050 | 1 | 0.649 |
TAO3 |
0.706 | -0.058 | 1 | 0.753 |
GRK3 |
0.705 | -0.017 | -2 | 0.679 |
PKN1 |
0.705 | -0.025 | -3 | 0.779 |
P38D |
0.705 | 0.012 | 1 | 0.486 |
CAMKK1 |
0.705 | -0.029 | -2 | 0.803 |
CK1G1 |
0.704 | -0.053 | -3 | 0.521 |
HIPK3 |
0.704 | -0.039 | 1 | 0.647 |
CDK16 |
0.704 | -0.012 | 1 | 0.494 |
AKT3 |
0.703 | 0.029 | -3 | 0.676 |
CHK2 |
0.703 | 0.023 | -3 | 0.699 |
PINK1 |
0.702 | -0.133 | 1 | 0.822 |
CAMK1A |
0.702 | 0.004 | -3 | 0.714 |
LKB1 |
0.702 | -0.018 | -3 | 0.819 |
GCK |
0.702 | 0.023 | 1 | 0.763 |
NEK8 |
0.701 | -0.128 | 2 | 0.211 |
CDK12 |
0.701 | -0.060 | 1 | 0.533 |
TAK1 |
0.701 | 0.030 | 1 | 0.792 |
TAO2 |
0.700 | -0.081 | 2 | 0.205 |
EEF2K |
0.700 | -0.067 | 3 | 0.761 |
CK1A2 |
0.699 | -0.031 | -3 | 0.475 |
PDK1 |
0.699 | -0.071 | 1 | 0.747 |
ROCK1 |
0.699 | 0.063 | -3 | 0.812 |
HPK1 |
0.699 | 0.023 | 1 | 0.743 |
CK1D |
0.698 | -0.028 | -3 | 0.472 |
CAMKK2 |
0.698 | -0.066 | -2 | 0.803 |
VRK1 |
0.698 | -0.056 | 2 | 0.227 |
LRRK2 |
0.697 | -0.082 | 2 | 0.222 |
MEKK6 |
0.697 | -0.097 | 1 | 0.770 |
MOK |
0.697 | 0.021 | 1 | 0.732 |
NEK4 |
0.697 | -0.099 | 1 | 0.773 |
CDK3 |
0.697 | -0.025 | 1 | 0.498 |
LOK |
0.696 | -0.042 | -2 | 0.811 |
MAK |
0.694 | 0.023 | -2 | 0.762 |
PDHK3_TYR |
0.694 | 0.196 | 4 | 0.659 |
SLK |
0.694 | -0.012 | -2 | 0.762 |
MST2 |
0.694 | -0.079 | 1 | 0.776 |
SBK |
0.694 | 0.030 | -3 | 0.627 |
RIPK2 |
0.694 | -0.100 | 1 | 0.691 |
CRIK |
0.693 | 0.044 | -3 | 0.749 |
NEK1 |
0.693 | -0.071 | 1 | 0.791 |
PBK |
0.693 | 0.008 | 1 | 0.797 |
TNIK |
0.692 | -0.072 | 3 | 0.772 |
MAP3K15 |
0.691 | -0.125 | 1 | 0.712 |
MINK |
0.690 | -0.104 | 1 | 0.760 |
MST1 |
0.690 | -0.057 | 1 | 0.764 |
KHS2 |
0.689 | -0.023 | 1 | 0.753 |
PKG1 |
0.688 | -0.016 | -2 | 0.593 |
HGK |
0.688 | -0.118 | 3 | 0.780 |
KHS1 |
0.687 | -0.049 | 1 | 0.743 |
MEK2 |
0.687 | -0.141 | 2 | 0.194 |
YSK1 |
0.687 | -0.104 | 2 | 0.188 |
PDHK4_TYR |
0.686 | 0.162 | 2 | 0.293 |
CDK4 |
0.685 | -0.050 | 1 | 0.524 |
BUB1 |
0.684 | -0.052 | -5 | 0.607 |
CDK6 |
0.684 | -0.055 | 1 | 0.546 |
MAP2K6_TYR |
0.684 | 0.143 | -1 | 0.809 |
EPHA6 |
0.683 | 0.094 | -1 | 0.789 |
TTK |
0.683 | -0.068 | -2 | 0.828 |
EPHA4 |
0.682 | 0.139 | 2 | 0.307 |
TESK1_TYR |
0.681 | -0.011 | 3 | 0.838 |
EPHB4 |
0.681 | 0.116 | -1 | 0.790 |
MAP2K7_TYR |
0.680 | -0.010 | 2 | 0.245 |
MAP2K4_TYR |
0.679 | 0.016 | -1 | 0.813 |
HASPIN |
0.679 | -0.042 | -1 | 0.637 |
SRMS |
0.679 | 0.185 | 1 | 0.840 |
PDHK1_TYR |
0.678 | 0.069 | -1 | 0.814 |
DDR1 |
0.678 | 0.065 | 4 | 0.578 |
TNK2 |
0.678 | 0.083 | 3 | 0.778 |
BIKE |
0.677 | 0.014 | 1 | 0.747 |
BMPR2_TYR |
0.677 | 0.057 | -1 | 0.783 |
TXK |
0.677 | 0.141 | 1 | 0.829 |
ALPHAK3 |
0.676 | -0.016 | -1 | 0.709 |
PKMYT1_TYR |
0.675 | -0.083 | 3 | 0.828 |
OSR1 |
0.675 | -0.106 | 2 | 0.203 |
EPHB1 |
0.675 | 0.120 | 1 | 0.831 |
ITK |
0.674 | 0.150 | -1 | 0.769 |
EPHB3 |
0.674 | 0.108 | -1 | 0.780 |
LIMK2_TYR |
0.673 | -0.037 | -3 | 0.894 |
MERTK |
0.673 | 0.097 | 3 | 0.799 |
MYO3B |
0.673 | -0.101 | 2 | 0.190 |
YANK2 |
0.673 | -0.050 | 2 | 0.145 |
YES1 |
0.672 | 0.062 | -1 | 0.795 |
RET |
0.671 | -0.010 | 1 | 0.768 |
PINK1_TYR |
0.671 | -0.101 | 1 | 0.810 |
TYRO3 |
0.671 | -0.010 | 3 | 0.780 |
DDR2 |
0.671 | 0.118 | 3 | 0.774 |
EPHB2 |
0.671 | 0.102 | -1 | 0.768 |
ASK1 |
0.671 | -0.111 | 1 | 0.695 |
EPHA7 |
0.671 | 0.085 | 2 | 0.278 |
NEK3 |
0.671 | -0.181 | 1 | 0.717 |
AXL |
0.670 | 0.049 | 3 | 0.803 |
BMX |
0.669 | 0.122 | -1 | 0.693 |
INSRR |
0.669 | 0.027 | 3 | 0.778 |
FER |
0.668 | 0.025 | 1 | 0.859 |
CK1A |
0.668 | -0.051 | -3 | 0.380 |
EPHA3 |
0.668 | 0.052 | 2 | 0.269 |
FGFR2 |
0.668 | 0.035 | 3 | 0.825 |
TEK |
0.667 | 0.053 | 3 | 0.761 |
TAO1 |
0.667 | -0.113 | 1 | 0.673 |
EPHA5 |
0.666 | 0.111 | 2 | 0.300 |
FGR |
0.666 | -0.010 | 1 | 0.865 |
MYO3A |
0.666 | -0.127 | 1 | 0.767 |
BLK |
0.666 | 0.080 | -1 | 0.769 |
ROS1 |
0.665 | -0.102 | 3 | 0.773 |
PTK2B |
0.665 | 0.089 | -1 | 0.744 |
MST1R |
0.665 | -0.062 | 3 | 0.796 |
ABL2 |
0.665 | -0.002 | -1 | 0.762 |
CSF1R |
0.664 | -0.016 | 3 | 0.791 |
LIMK1_TYR |
0.664 | -0.181 | 2 | 0.198 |
PTK2 |
0.663 | 0.094 | -1 | 0.700 |
TEC |
0.663 | 0.067 | -1 | 0.735 |
FYN |
0.662 | 0.089 | -1 | 0.726 |
HCK |
0.662 | 0.008 | -1 | 0.779 |
ABL1 |
0.661 | -0.017 | -1 | 0.760 |
FGFR3 |
0.661 | 0.050 | 3 | 0.808 |
TYK2 |
0.661 | -0.167 | 1 | 0.769 |
TNK1 |
0.661 | -0.060 | 3 | 0.771 |
STLK3 |
0.661 | -0.133 | 1 | 0.707 |
KDR |
0.661 | -0.016 | 3 | 0.787 |
KIT |
0.661 | 0.026 | 3 | 0.797 |
LTK |
0.660 | -0.026 | 3 | 0.760 |
JAK3 |
0.660 | -0.041 | 1 | 0.735 |
EPHA1 |
0.660 | 0.021 | 3 | 0.773 |
LCK |
0.659 | 0.013 | -1 | 0.767 |
AAK1 |
0.658 | 0.024 | 1 | 0.653 |
BTK |
0.658 | 0.010 | -1 | 0.772 |
JAK2 |
0.658 | -0.143 | 1 | 0.751 |
PDGFRB |
0.657 | -0.124 | 3 | 0.797 |
FGFR1 |
0.657 | -0.063 | 3 | 0.796 |
EPHA8 |
0.655 | 0.037 | -1 | 0.738 |
FLT3 |
0.654 | -0.069 | 3 | 0.778 |
MET |
0.654 | -0.021 | 3 | 0.782 |
NTRK1 |
0.654 | -0.038 | -1 | 0.756 |
EPHA2 |
0.654 | 0.080 | -1 | 0.715 |
FLT1 |
0.654 | 0.015 | -1 | 0.752 |
ALK |
0.653 | -0.084 | 3 | 0.735 |
FRK |
0.653 | 0.005 | -1 | 0.800 |
TNNI3K_TYR |
0.653 | -0.124 | 1 | 0.810 |
WEE1_TYR |
0.652 | -0.065 | -1 | 0.715 |
FLT4 |
0.652 | -0.035 | 3 | 0.790 |
ERBB2 |
0.651 | -0.049 | 1 | 0.723 |
LYN |
0.651 | 0.017 | 3 | 0.735 |
CSK |
0.650 | -0.002 | 2 | 0.262 |
PTK6 |
0.650 | -0.131 | -1 | 0.704 |
SRC |
0.649 | 0.023 | -1 | 0.734 |
INSR |
0.649 | -0.071 | 3 | 0.747 |
NEK10_TYR |
0.647 | -0.113 | 1 | 0.610 |
MATK |
0.647 | -0.016 | -1 | 0.676 |
PDGFRA |
0.647 | -0.180 | 3 | 0.789 |
FGFR4 |
0.646 | 0.009 | -1 | 0.707 |
CK1G3 |
0.645 | -0.057 | -3 | 0.338 |
JAK1 |
0.645 | -0.123 | 1 | 0.685 |
EGFR |
0.645 | -0.014 | 1 | 0.631 |
NTRK2 |
0.645 | -0.106 | 3 | 0.775 |
NTRK3 |
0.642 | -0.067 | -1 | 0.708 |
ERBB4 |
0.641 | 0.022 | 1 | 0.666 |
SYK |
0.640 | 0.037 | -1 | 0.682 |
IGF1R |
0.640 | -0.036 | 3 | 0.704 |
FES |
0.633 | -0.016 | -1 | 0.664 |
CK1G2 |
0.629 | -0.047 | -3 | 0.436 |
MUSK |
0.623 | -0.130 | 1 | 0.642 |
ZAP70 |
0.614 | -0.008 | -1 | 0.607 |