Motif 363 (n=117)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RU30 | TESPA1 | S476 | ochoa | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}. |
| A8CG34 | POM121C | S260 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| E9PCH4 | None | S776 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| O15126 | SCAMP1 | S41 | ochoa | Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O43426 | SYNJ1 | S1383 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43432 | EIF4G3 | S1112 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43516 | WIPF1 | S342 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O43900 | PRICKLE3 | S381 | ochoa | Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) | Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. |
| O60292 | SIPA1L3 | S1383 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O75152 | ZC3H11A | S735 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O95835 | LATS1 | S462 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P04150 | NR3C1 | S132 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P08069 | IGF1R | S1310 | ochoa|psp | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P11137 | MAP2 | S1598 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11274 | BCR | S299 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P11362 | FGFR1 | S450 | ochoa | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P15056 | BRAF | S727 | ochoa | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P19419 | ELK1 | S389 | psp | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P30281 | CCND3 | S273 | ochoa | G1/S-specific cyclin-D3 | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}. |
| P30414 | NKTR | S611 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P31629 | HIVEP2 | S563 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P42566 | EPS15 | S605 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P50616 | TOB1 | S150 | ochoa | Protein Tob1 (Transducer of erbB-2 1) | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}. |
| P51825 | AFF1 | S871 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P53814 | SMTN | S500 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P57682 | KLF3 | S222 | ochoa | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| Q00587 | CDC42EP1 | S25 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q03164 | KMT2A | S828 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07889 | SOS1 | S1132 | psp | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q09019 | DMWD | S493 | ochoa | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}. |
| Q12774 | ARHGEF5 | S627 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12774 | ARHGEF5 | Y641 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13470 | TNK1 | S543 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q13938 | CAPS | S40 | ochoa | Calcyphosin (Calcyphosine) | Calcium-binding protein. May play a role in cellular signaling events (Potential). {ECO:0000305}. |
| Q14596 | NBR1 | S824 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14721 | KCNB1 | S517 | ochoa | Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:10484328, PubMed:12560340, PubMed:1283219, PubMed:19074135, PubMed:19717558, PubMed:24901643, PubMed:8081723). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}. |
| Q14767 | LTBP2 | S249 | ochoa | Latent-transforming growth factor beta-binding protein 2 (LTBP-2) | May play an integral structural role in elastic-fiber architectural organization and/or assembly. {ECO:0000303|PubMed:10743502, ECO:0000303|PubMed:11104663}. |
| Q14978 | NOLC1 | Y289 | ochoa|psp | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14978 | NOLC1 | S290 | ochoa|psp | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15648 | MED1 | S1194 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15788 | NCOA1 | S393 | ochoa | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q15884 | ENTREP1 | S273 | ochoa | Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin) | Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway. {ECO:0000269|PubMed:34927784}. |
| Q15942 | ZYX | S204 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q2KJY2 | KIF26B | S1491 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q5HYK7 | SH3D19 | S148 | ochoa | SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) | May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:14551139, ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. |
| Q5T200 | ZC3H13 | S370 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5P2 | KIAA1217 | S1894 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5UIP0 | RIF1 | S1198 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q63ZY3 | KANK2 | S172 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q63ZY3 | KANK2 | S425 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q68DK7 | MSL1 | S392 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6P0Q8 | MAST2 | S874 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6UUV9 | CRTC1 | S167 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6ZNL6 | FGD5 | S699 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZU65 | UBN2 | S1090 | ochoa | Ubinuclein-2 | None |
| Q702N8 | XIRP1 | S1666 | ochoa | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}. |
| Q7Z333 | SETX | S2472 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q7Z5H3 | ARHGAP22 | S556 | ochoa | Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
| Q7Z6B7 | SRGAP1 | S938 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86UP3 | ZFHX4 | S2724 | ochoa | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q86UU0 | BCL9L | S1051 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU0 | BCL9L | S1052 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86VE0 | MYPOP | S176 | ochoa | Myb-related transcription factor, partner of profilin (Myb-related protein p42POP) (Partner of profilin) | Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity). {ECO:0000250}. |
| Q86X10 | RALGAPB | S357 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q8IVT5 | KSR1 | S267 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8IZ21 | PHACTR4 | S176 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N3F8 | MICALL1 | S536 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4L1 | TMEM151A | S421 | ochoa | Transmembrane protein 151A | None |
| Q8N5C8 | TAB3 | S357 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N5Y2 | MSL3 | S398 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
| Q8N684 | CPSF7 | S46 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8NFZ0 | FBH1 | S124 | ochoa | F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18) | 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578). {ECO:0000269|PubMed:11956208, ECO:0000269|PubMed:17724085, ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23361013, ECO:0000269|PubMed:25585578, ECO:0000269|PubMed:25772361}. |
| Q8TAB5 | C1orf216 | S60 | ochoa | UPF0500 protein C1orf216 | None |
| Q8TBZ3 | WDR20 | S432 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8TEU7 | RAPGEF6 | S726 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TEY7 | USP33 | S443 | ochoa | Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) | Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}. |
| Q8WWI1 | LMO7 | S1563 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWN8 | ARAP3 | S1471 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
| Q92667 | AKAP1 | S105 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92698 | RAD54L | S37 | ochoa | DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54) | Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:11459989, PubMed:12205100, PubMed:24798879, PubMed:27264870, PubMed:32457312, PubMed:9774452). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). {ECO:0000250|UniProtKB:P32863, ECO:0000269|PubMed:11459989, ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:27264870, ECO:0000269|PubMed:32457312, ECO:0000269|PubMed:9774452}. |
| Q92794 | KAT6A | S999 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q92835 | INPP5D | S1024 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q92934 | BAD | S97 | ochoa|psp | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q96HA1 | POM121 | S283 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96HP0 | DOCK6 | S1230 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96N67 | DOCK7 | S862 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96PE2 | ARHGEF17 | S860 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PU5 | NEDD4L | S340 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96QT6 | PHF12 | S648 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q9BRK4 | LZTS2 | S224 | ochoa|psp | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BSJ8 | ESYT1 | S1011 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9H0H5 | RACGAP1 | S259 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H201 | EPN3 | S188 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H8N7 | ZNF395 | S447 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9NYF3 | FAM53C | S82 | ochoa | Protein FAM53C | None |
| Q9P242 | NYAP2 | S411 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P2D1 | CHD7 | S557 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UBU9 | NXF1 | S556 | ochoa | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
| Q9UHR4 | BAIAP2L1 | S329 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UK96 | FBXO10 | S324 | ochoa | F-box only protein 10 | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation (PubMed:28515150). Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling (PubMed:31570756). {ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:28515150, ECO:0000269|PubMed:31570756}. |
| Q9UKV5 | AMFR | S507 | ochoa | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296). Required for proper lipid homeostasis (PubMed:37119330). {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:12670940, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:17043353, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:31073040, ECO:0000269|PubMed:31953408, ECO:0000269|PubMed:36593296, ECO:0000269|PubMed:37119330}. |
| Q9ULD2 | MTUS1 | S197 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULJ3 | ZBTB21 | S409 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULK4 | MED23 | S1350 | ochoa | Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) | Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:10353252, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:16595664}. |
| Q9UPN4 | CEP131 | S76 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPQ0 | LIMCH1 | S469 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPU9 | SAMD4A | S419 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9UQ35 | SRRM2 | S817 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2I7 | PIKFYVE | S305 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y2J4 | AMOTL2 | S180 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2L6 | FRMD4B | S662 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y490 | TLN1 | S455 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G6 | TLN2 | S458 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y4G8 | RAPGEF2 | S583 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y6K9 | IKBKG | Y374 | ochoa|psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| O60828 | PQBP1 | S208 | Sugiyama | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| P50395 | GDI2 | S43 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.236759e-09 | 8.650 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.872538e-05 | 4.312 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.804443e-04 | 3.552 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.201993e-04 | 3.284 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 7.517098e-04 | 3.124 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 1.814328e-03 | 2.741 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.748605e-03 | 2.757 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.748605e-03 | 2.757 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 1.990468e-03 | 2.701 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.292398e-03 | 2.640 |
| R-HSA-2428924 | IGF1R signaling cascade | 2.669218e-03 | 2.574 |
| R-HSA-73887 | Death Receptor Signaling | 2.557694e-03 | 2.592 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.803713e-03 | 2.552 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.786529e-03 | 2.422 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.062128e-03 | 2.391 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.050501e-03 | 2.392 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.786529e-03 | 2.422 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.050501e-03 | 2.392 |
| R-HSA-162582 | Signal Transduction | 3.566651e-03 | 2.448 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.649182e-03 | 2.333 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.285005e-03 | 2.277 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 6.426193e-03 | 2.192 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.970672e-03 | 2.224 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.332509e-03 | 2.198 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.849304e-03 | 2.233 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.970672e-03 | 2.224 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 7.094768e-03 | 2.149 |
| R-HSA-5674135 | MAP2K and MAPK activation | 7.094768e-03 | 2.149 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 7.274194e-03 | 2.138 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.565067e-02 | 1.805 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.565067e-02 | 1.805 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.565067e-02 | 1.805 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.565067e-02 | 1.805 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.565067e-02 | 1.805 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.113559e-02 | 1.953 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 1.333709e-02 | 1.875 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.230319e-03 | 2.035 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.230319e-03 | 2.035 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.230319e-03 | 2.035 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.048426e-02 | 1.689 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 1.450290e-02 | 1.839 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.095331e-02 | 1.679 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.859474e-03 | 2.006 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.230319e-03 | 2.035 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.055712e-02 | 1.976 |
| R-HSA-2028269 | Signaling by Hippo | 1.333709e-02 | 1.875 |
| R-HSA-74751 | Insulin receptor signalling cascade | 1.976480e-02 | 1.704 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.164597e-02 | 1.934 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.302900e-02 | 1.885 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.825173e-02 | 1.739 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.236271e-02 | 1.650 |
| R-HSA-112399 | IRS-mediated signalling | 1.512742e-02 | 1.820 |
| R-HSA-190236 | Signaling by FGFR | 1.123409e-02 | 1.949 |
| R-HSA-3214847 | HATs acetylate histones | 1.158282e-02 | 1.936 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.916039e-03 | 2.050 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.023669e-02 | 1.990 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.958276e-02 | 1.708 |
| R-HSA-450294 | MAP kinase activation | 1.769204e-02 | 1.752 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.720930e-02 | 1.764 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.928856e-02 | 1.715 |
| R-HSA-9707616 | Heme signaling | 1.836871e-02 | 1.736 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.158282e-02 | 1.936 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 2.338463e-02 | 1.631 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 2.338463e-02 | 1.631 |
| R-HSA-448424 | Interleukin-17 signaling | 2.429591e-02 | 1.614 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.681710e-02 | 1.572 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.837508e-02 | 1.547 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.846461e-02 | 1.546 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.325941e-02 | 1.478 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.495553e-02 | 1.456 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.495553e-02 | 1.456 |
| R-HSA-9843745 | Adipogenesis | 2.966322e-02 | 1.528 |
| R-HSA-9909396 | Circadian clock | 3.029936e-02 | 1.519 |
| R-HSA-6806834 | Signaling by MET | 3.298866e-02 | 1.482 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.325941e-02 | 1.478 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.113657e-02 | 1.507 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.393585e-02 | 1.469 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.668462e-02 | 1.436 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 3.867215e-02 | 1.413 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 4.622663e-02 | 1.335 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 5.372221e-02 | 1.270 |
| R-HSA-112412 | SOS-mediated signalling | 7.586008e-02 | 1.120 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 7.586008e-02 | 1.120 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 8.312457e-02 | 1.080 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 8.312457e-02 | 1.080 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 8.312457e-02 | 1.080 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.116203e-01 | 0.952 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.186059e-01 | 0.926 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.255369e-01 | 0.901 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.392372e-01 | 0.856 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.844606e-02 | 1.415 |
| R-HSA-5673000 | RAF activation | 4.206358e-02 | 1.376 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.391846e-02 | 1.357 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.527245e-01 | 0.816 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.593893e-01 | 0.798 |
| R-HSA-72187 | mRNA 3'-end processing | 8.189866e-02 | 1.087 |
| R-HSA-1989781 | PPARA activates gene expression | 1.571454e-01 | 0.804 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.660021e-01 | 0.780 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.609158e-01 | 0.793 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.786479e-02 | 1.422 |
| R-HSA-354192 | Integrin signaling | 3.844606e-02 | 1.415 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 9.962567e-02 | 1.002 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 9.962567e-02 | 1.002 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.527245e-01 | 0.816 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.617669e-02 | 1.179 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 9.962567e-02 | 1.002 |
| R-HSA-8849473 | PTK6 Expression | 7.586008e-02 | 1.120 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.255369e-01 | 0.901 |
| R-HSA-8851805 | MET activates RAS signaling | 1.186059e-01 | 0.926 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.527245e-01 | 0.816 |
| R-HSA-74749 | Signal attenuation | 9.748402e-02 | 1.011 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.799728e-02 | 1.319 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 6.115935e-02 | 1.214 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 9.033241e-02 | 1.044 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 9.748402e-02 | 1.011 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 1.045799e-01 | 0.981 |
| R-HSA-428540 | Activation of RAC1 | 1.116203e-01 | 0.952 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 1.116203e-01 | 0.952 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.255369e-01 | 0.901 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.392372e-01 | 0.856 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.392372e-01 | 0.856 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.392372e-01 | 0.856 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.206358e-02 | 1.376 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.527245e-01 | 0.816 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.771756e-02 | 1.321 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 1.855324e-01 | 0.732 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.617669e-02 | 1.179 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.035765e-01 | 0.985 |
| R-HSA-170968 | Frs2-mediated activation | 1.255369e-01 | 0.901 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.206358e-02 | 1.376 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.593893e-01 | 0.798 |
| R-HSA-169893 | Prolonged ERK activation events | 1.460073e-01 | 0.836 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 7.055610e-02 | 1.151 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 8.312457e-02 | 1.080 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 9.033241e-02 | 1.044 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 9.748402e-02 | 1.011 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.324139e-01 | 0.878 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.023925e-02 | 1.395 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.770998e-02 | 1.239 |
| R-HSA-187687 | Signalling to ERKs | 4.391846e-02 | 1.357 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 6.115935e-02 | 1.214 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 6.115935e-02 | 1.214 |
| R-HSA-170984 | ARMS-mediated activation | 9.033241e-02 | 1.044 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 9.748402e-02 | 1.011 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.116203e-01 | 0.952 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.392372e-01 | 0.856 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.725633e-01 | 0.763 |
| R-HSA-194441 | Metabolism of non-coding RNA | 9.863160e-02 | 1.006 |
| R-HSA-191859 | snRNP Assembly | 9.863160e-02 | 1.006 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.035765e-01 | 0.985 |
| R-HSA-9664873 | Pexophagy | 9.748402e-02 | 1.011 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 7.278056e-02 | 1.138 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.392372e-01 | 0.856 |
| R-HSA-74752 | Signaling by Insulin receptor | 4.751328e-02 | 1.323 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 1.186059e-01 | 0.926 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.392372e-01 | 0.856 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.392372e-01 | 0.856 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.206358e-02 | 1.376 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.571454e-01 | 0.804 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.460073e-01 | 0.836 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.660021e-01 | 0.780 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.186059e-01 | 0.926 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.186059e-01 | 0.926 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.186059e-01 | 0.926 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.324139e-01 | 0.878 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.392372e-01 | 0.856 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.363099e-02 | 1.271 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.363099e-02 | 1.271 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.565718e-02 | 1.254 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.002552e-02 | 1.155 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 9.033241e-02 | 1.044 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.593893e-01 | 0.798 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.593893e-01 | 0.798 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.725633e-01 | 0.763 |
| R-HSA-177929 | Signaling by EGFR | 9.134661e-02 | 1.039 |
| R-HSA-983189 | Kinesins | 1.010955e-01 | 0.995 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.577193e-02 | 1.254 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.577193e-02 | 1.254 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.577193e-02 | 1.254 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.277815e-02 | 1.138 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.277815e-02 | 1.138 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.598792e-02 | 1.181 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 6.115935e-02 | 1.214 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.045799e-01 | 0.981 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.045799e-01 | 0.981 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.966063e-02 | 1.304 |
| R-HSA-167044 | Signalling to RAS | 1.855324e-01 | 0.732 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.835465e-02 | 1.165 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.318803e-01 | 0.880 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.139580e-02 | 1.146 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.875623e-02 | 1.052 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.111179e-01 | 0.954 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.875623e-02 | 1.052 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 9.335031e-02 | 1.030 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.699678e-02 | 1.114 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 9.335031e-02 | 1.030 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.132100e-02 | 1.090 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.392372e-01 | 0.856 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.593893e-01 | 0.798 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.660021e-01 | 0.780 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.060742e-01 | 0.974 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.855324e-01 | 0.732 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.855324e-01 | 0.732 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.441775e-01 | 0.841 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 6.115935e-02 | 1.214 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.593893e-01 | 0.798 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.163196e-02 | 1.287 |
| R-HSA-109704 | PI3K Cascade | 7.729651e-02 | 1.112 |
| R-HSA-202424 | Downstream TCR signaling | 1.840749e-01 | 0.735 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.291627e-01 | 0.889 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 9.375672e-02 | 1.028 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.189328e-02 | 1.208 |
| R-HSA-1483255 | PI Metabolism | 6.077833e-02 | 1.216 |
| R-HSA-210990 | PECAM1 interactions | 1.045799e-01 | 0.981 |
| R-HSA-210993 | Tie2 Signaling | 1.660021e-01 | 0.780 |
| R-HSA-198753 | ERK/MAPK targets | 1.855324e-01 | 0.732 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.060742e-01 | 0.974 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.617669e-02 | 1.179 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.044413e-01 | 0.981 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.324139e-01 | 0.878 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.060742e-01 | 0.974 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.534409e-01 | 0.814 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.856318e-02 | 1.414 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 7.586008e-02 | 1.120 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.324139e-01 | 0.878 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.392372e-01 | 0.856 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.460073e-01 | 0.836 |
| R-HSA-166520 | Signaling by NTRKs | 1.441775e-01 | 0.841 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.959041e-02 | 1.002 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 6.189328e-02 | 1.208 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.186059e-01 | 0.926 |
| R-HSA-8939211 | ESR-mediated signaling | 1.463199e-01 | 0.835 |
| R-HSA-9842663 | Signaling by LTK | 1.186059e-01 | 0.926 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.724678e-02 | 1.059 |
| R-HSA-445144 | Signal transduction by L1 | 1.790733e-01 | 0.747 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.335714e-01 | 0.874 |
| R-HSA-75893 | TNF signaling | 9.134661e-02 | 1.039 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.844606e-02 | 1.415 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.790733e-01 | 0.747 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.150809e-02 | 1.288 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.085881e-01 | 0.964 |
| R-HSA-4839726 | Chromatin organization | 6.268081e-02 | 1.203 |
| R-HSA-74160 | Gene expression (Transcription) | 1.007315e-01 | 0.997 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.186059e-01 | 0.926 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.507082e-01 | 0.822 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.206358e-02 | 1.376 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.574845e-02 | 1.067 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.978886e-02 | 1.223 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.333648e-01 | 0.875 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.363099e-02 | 1.271 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.616959e-01 | 0.791 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.799728e-02 | 1.319 |
| R-HSA-212436 | Generic Transcription Pathway | 1.755990e-01 | 0.755 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.281475e-01 | 0.892 |
| R-HSA-162587 | HIV Life Cycle | 1.609158e-01 | 0.793 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.728245e-01 | 0.762 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.228544e-01 | 0.911 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.897400e-01 | 0.722 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 1.919412e-01 | 0.717 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 1.919412e-01 | 0.717 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.919412e-01 | 0.717 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.919412e-01 | 0.717 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 1.919412e-01 | 0.717 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.919412e-01 | 0.717 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.939983e-01 | 0.712 |
| R-HSA-9824446 | Viral Infection Pathways | 1.950547e-01 | 0.710 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.982815e-01 | 0.703 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 1.982999e-01 | 0.703 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.982999e-01 | 0.703 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.982999e-01 | 0.703 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.982999e-01 | 0.703 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.046089e-01 | 0.689 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.046089e-01 | 0.689 |
| R-HSA-168255 | Influenza Infection | 2.060602e-01 | 0.686 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.068694e-01 | 0.684 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.068694e-01 | 0.684 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.097412e-01 | 0.678 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.108687e-01 | 0.676 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.108687e-01 | 0.676 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.108687e-01 | 0.676 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.108687e-01 | 0.676 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.170796e-01 | 0.663 |
| R-HSA-70171 | Glycolysis | 2.183803e-01 | 0.661 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.212673e-01 | 0.655 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.212673e-01 | 0.655 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.232420e-01 | 0.651 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.232420e-01 | 0.651 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.232420e-01 | 0.651 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.232420e-01 | 0.651 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.232420e-01 | 0.651 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 2.232420e-01 | 0.651 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.241574e-01 | 0.649 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 2.293563e-01 | 0.639 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 2.293563e-01 | 0.639 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.293563e-01 | 0.639 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.293563e-01 | 0.639 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.293563e-01 | 0.639 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.299464e-01 | 0.638 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.306680e-01 | 0.637 |
| R-HSA-9833110 | RSV-host interactions | 2.328448e-01 | 0.633 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 2.354228e-01 | 0.628 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.354228e-01 | 0.628 |
| R-HSA-9609690 | HCMV Early Events | 2.410820e-01 | 0.618 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.414419e-01 | 0.617 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.414419e-01 | 0.617 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.414419e-01 | 0.617 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.414419e-01 | 0.617 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.414419e-01 | 0.617 |
| R-HSA-211000 | Gene Silencing by RNA | 2.415532e-01 | 0.617 |
| R-HSA-2424491 | DAP12 signaling | 2.474141e-01 | 0.607 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.474141e-01 | 0.607 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.474141e-01 | 0.607 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.474141e-01 | 0.607 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.474141e-01 | 0.607 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.474141e-01 | 0.607 |
| R-HSA-202403 | TCR signaling | 2.502768e-01 | 0.602 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.533395e-01 | 0.596 |
| R-HSA-182971 | EGFR downregulation | 2.533395e-01 | 0.596 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.533395e-01 | 0.596 |
| R-HSA-186763 | Downstream signal transduction | 2.533395e-01 | 0.596 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.533395e-01 | 0.596 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.557908e-01 | 0.592 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.592187e-01 | 0.586 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.619228e-01 | 0.582 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.650520e-01 | 0.577 |
| R-HSA-159418 | Recycling of bile acids and salts | 2.650520e-01 | 0.577 |
| R-HSA-70326 | Glucose metabolism | 2.764863e-01 | 0.558 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.765821e-01 | 0.558 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.765821e-01 | 0.558 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.765821e-01 | 0.558 |
| R-HSA-199991 | Membrane Trafficking | 2.768163e-01 | 0.558 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.810698e-01 | 0.551 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.822797e-01 | 0.549 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 2.822797e-01 | 0.549 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.822797e-01 | 0.549 |
| R-HSA-68875 | Mitotic Prophase | 2.852191e-01 | 0.545 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.863297e-01 | 0.543 |
| R-HSA-9845576 | Glycosphingolipid transport | 2.879328e-01 | 0.541 |
| R-HSA-8853659 | RET signaling | 2.879328e-01 | 0.541 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.879328e-01 | 0.541 |
| R-HSA-3371556 | Cellular response to heat stress | 2.881281e-01 | 0.540 |
| R-HSA-422475 | Axon guidance | 2.892472e-01 | 0.539 |
| R-HSA-1296072 | Voltage gated Potassium channels | 2.935417e-01 | 0.532 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.935417e-01 | 0.532 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.935417e-01 | 0.532 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.939423e-01 | 0.532 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.968472e-01 | 0.527 |
| R-HSA-8875878 | MET promotes cell motility | 2.991067e-01 | 0.524 |
| R-HSA-1566948 | Elastic fibre formation | 2.991067e-01 | 0.524 |
| R-HSA-109582 | Hemostasis | 3.028022e-01 | 0.519 |
| R-HSA-9679506 | SARS-CoV Infections | 3.029274e-01 | 0.519 |
| R-HSA-162906 | HIV Infection | 3.091433e-01 | 0.510 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.101067e-01 | 0.508 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.101067e-01 | 0.508 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.101067e-01 | 0.508 |
| R-HSA-5260271 | Diseases of Immune System | 3.101067e-01 | 0.508 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.101067e-01 | 0.508 |
| R-HSA-1643685 | Disease | 3.148536e-01 | 0.502 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.155422e-01 | 0.501 |
| R-HSA-9607240 | FLT3 Signaling | 3.155422e-01 | 0.501 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.155422e-01 | 0.501 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.171257e-01 | 0.499 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.209353e-01 | 0.494 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.257787e-01 | 0.487 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.262862e-01 | 0.486 |
| R-HSA-73928 | Depyrimidination | 3.262862e-01 | 0.486 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.262862e-01 | 0.486 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.315953e-01 | 0.479 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.324144e-01 | 0.478 |
| R-HSA-69236 | G1 Phase | 3.368629e-01 | 0.473 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.368629e-01 | 0.473 |
| R-HSA-2172127 | DAP12 interactions | 3.368629e-01 | 0.473 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.401366e-01 | 0.468 |
| R-HSA-9675108 | Nervous system development | 3.404164e-01 | 0.468 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.472748e-01 | 0.459 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.487077e-01 | 0.458 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.574323e-01 | 0.447 |
| R-HSA-9031628 | NGF-stimulated transcription | 3.575245e-01 | 0.447 |
| R-HSA-9609646 | HCMV Infection | 3.585958e-01 | 0.445 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.625893e-01 | 0.441 |
| R-HSA-9766229 | Degradation of CDH1 | 3.625893e-01 | 0.441 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.629099e-01 | 0.440 |
| R-HSA-8953854 | Metabolism of RNA | 3.631854e-01 | 0.440 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 3.657370e-01 | 0.437 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 3.676145e-01 | 0.435 |
| R-HSA-5688426 | Deubiquitination | 3.693089e-01 | 0.433 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.726004e-01 | 0.429 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.775472e-01 | 0.423 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.824554e-01 | 0.417 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.824554e-01 | 0.417 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.825968e-01 | 0.417 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.873252e-01 | 0.412 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.881754e-01 | 0.411 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.881754e-01 | 0.411 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.909566e-01 | 0.408 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.949346e-01 | 0.403 |
| R-HSA-913531 | Interferon Signaling | 3.949346e-01 | 0.403 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.969507e-01 | 0.401 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.969507e-01 | 0.401 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.017071e-01 | 0.396 |
| R-HSA-9610379 | HCMV Late Events | 4.020249e-01 | 0.396 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.047775e-01 | 0.393 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.064262e-01 | 0.391 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.064262e-01 | 0.391 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.102647e-01 | 0.387 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.111084e-01 | 0.386 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.157540e-01 | 0.381 |
| R-HSA-211976 | Endogenous sterols | 4.203632e-01 | 0.376 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.203632e-01 | 0.376 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.203632e-01 | 0.376 |
| R-HSA-186797 | Signaling by PDGF | 4.249363e-01 | 0.372 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.249363e-01 | 0.372 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.264715e-01 | 0.370 |
| R-HSA-5619102 | SLC transporter disorders | 4.292738e-01 | 0.367 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.294736e-01 | 0.367 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.294736e-01 | 0.367 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.294736e-01 | 0.367 |
| R-HSA-8848021 | Signaling by PTK6 | 4.294736e-01 | 0.367 |
| R-HSA-373755 | Semaphorin interactions | 4.294736e-01 | 0.367 |
| R-HSA-2262752 | Cellular responses to stress | 4.354220e-01 | 0.361 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.393138e-01 | 0.357 |
| R-HSA-72306 | tRNA processing | 4.399926e-01 | 0.357 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.426554e-01 | 0.354 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.428736e-01 | 0.354 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.428736e-01 | 0.354 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.472704e-01 | 0.349 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 4.472704e-01 | 0.349 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.516329e-01 | 0.345 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.516329e-01 | 0.345 |
| R-HSA-1483257 | Phospholipid metabolism | 4.533877e-01 | 0.344 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.533877e-01 | 0.344 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.602556e-01 | 0.337 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.602556e-01 | 0.337 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.687438e-01 | 0.329 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.687438e-01 | 0.329 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.729380e-01 | 0.325 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.729380e-01 | 0.325 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.770995e-01 | 0.321 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.770995e-01 | 0.321 |
| R-HSA-380287 | Centrosome maturation | 4.812283e-01 | 0.318 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.816940e-01 | 0.317 |
| R-HSA-5663205 | Infectious disease | 4.850276e-01 | 0.314 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.893891e-01 | 0.310 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.013922e-01 | 0.300 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.013922e-01 | 0.300 |
| R-HSA-9833482 | PKR-mediated signaling | 5.013922e-01 | 0.300 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.018955e-01 | 0.299 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.053307e-01 | 0.296 |
| R-HSA-1640170 | Cell Cycle | 5.161790e-01 | 0.287 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.166813e-01 | 0.287 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.169619e-01 | 0.287 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.169619e-01 | 0.287 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.207783e-01 | 0.283 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.245649e-01 | 0.280 |
| R-HSA-72172 | mRNA Splicing | 5.287815e-01 | 0.277 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.357472e-01 | 0.271 |
| R-HSA-156902 | Peptide chain elongation | 5.357472e-01 | 0.271 |
| R-HSA-9663891 | Selective autophagy | 5.357472e-01 | 0.271 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.394164e-01 | 0.268 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.430568e-01 | 0.265 |
| R-HSA-73884 | Base Excision Repair | 5.430568e-01 | 0.265 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.458332e-01 | 0.263 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.466686e-01 | 0.262 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.502522e-01 | 0.259 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.538076e-01 | 0.257 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.573351e-01 | 0.254 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.643073e-01 | 0.248 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.643073e-01 | 0.248 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.677525e-01 | 0.246 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.677525e-01 | 0.246 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.677525e-01 | 0.246 |
| R-HSA-8951664 | Neddylation | 5.683798e-01 | 0.245 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.711706e-01 | 0.243 |
| R-HSA-1296071 | Potassium Channels | 5.711706e-01 | 0.243 |
| R-HSA-157579 | Telomere Maintenance | 5.745619e-01 | 0.241 |
| R-HSA-422356 | Regulation of insulin secretion | 5.779266e-01 | 0.238 |
| R-HSA-73894 | DNA Repair | 5.787994e-01 | 0.237 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.795656e-01 | 0.237 |
| R-HSA-449147 | Signaling by Interleukins | 5.798498e-01 | 0.237 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.812649e-01 | 0.236 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.812649e-01 | 0.236 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.878631e-01 | 0.231 |
| R-HSA-192823 | Viral mRNA Translation | 5.943582e-01 | 0.226 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.975675e-01 | 0.224 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.975675e-01 | 0.224 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 6.034291e-01 | 0.219 |
| R-HSA-1280218 | Adaptive Immune System | 6.097443e-01 | 0.215 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.101549e-01 | 0.215 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.101549e-01 | 0.215 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.101549e-01 | 0.215 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.132402e-01 | 0.212 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.132402e-01 | 0.212 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.132402e-01 | 0.212 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.132402e-01 | 0.212 |
| R-HSA-68886 | M Phase | 6.187033e-01 | 0.209 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.193383e-01 | 0.208 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.242328e-01 | 0.205 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.253411e-01 | 0.204 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.253411e-01 | 0.204 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.253411e-01 | 0.204 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.312499e-01 | 0.200 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.390953e-01 | 0.194 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.399402e-01 | 0.194 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.427915e-01 | 0.192 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.427915e-01 | 0.192 |
| R-HSA-373760 | L1CAM interactions | 6.427915e-01 | 0.192 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.456205e-01 | 0.190 |
| R-HSA-5693538 | Homology Directed Repair | 6.484272e-01 | 0.188 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.512119e-01 | 0.186 |
| R-HSA-73886 | Chromosome Maintenance | 6.567158e-01 | 0.183 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.621335e-01 | 0.179 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.651790e-01 | 0.177 |
| R-HSA-114608 | Platelet degranulation | 6.753094e-01 | 0.170 |
| R-HSA-69481 | G2/M Checkpoints | 6.753094e-01 | 0.170 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.762048e-01 | 0.170 |
| R-HSA-446728 | Cell junction organization | 6.833918e-01 | 0.165 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.839659e-01 | 0.165 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.929034e-01 | 0.159 |
| R-HSA-163685 | Integration of energy metabolism | 7.025290e-01 | 0.153 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.072290e-01 | 0.150 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.118552e-01 | 0.148 |
| R-HSA-9664407 | Parasite infection | 7.118552e-01 | 0.148 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.118552e-01 | 0.148 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.141411e-01 | 0.146 |
| R-HSA-1632852 | Macroautophagy | 7.141411e-01 | 0.146 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.274832e-01 | 0.138 |
| R-HSA-9758941 | Gastrulation | 7.339207e-01 | 0.134 |
| R-HSA-1500931 | Cell-Cell communication | 7.453624e-01 | 0.128 |
| R-HSA-9612973 | Autophagy | 7.483608e-01 | 0.126 |
| R-HSA-9711097 | Cellular response to starvation | 7.523418e-01 | 0.124 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.562603e-01 | 0.121 |
| R-HSA-8957322 | Metabolism of steroids | 7.570159e-01 | 0.121 |
| R-HSA-109581 | Apoptosis | 7.601173e-01 | 0.119 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.639137e-01 | 0.117 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 7.694969e-01 | 0.114 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.767378e-01 | 0.110 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.802732e-01 | 0.108 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.820200e-01 | 0.107 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.820200e-01 | 0.107 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.837530e-01 | 0.106 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.987477e-01 | 0.098 |
| R-HSA-69275 | G2/M Transition | 8.035130e-01 | 0.095 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.066275e-01 | 0.093 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.066275e-01 | 0.093 |
| R-HSA-983712 | Ion channel transport | 8.081663e-01 | 0.092 |
| R-HSA-5617833 | Cilium Assembly | 8.096930e-01 | 0.092 |
| R-HSA-68877 | Mitotic Prometaphase | 8.142011e-01 | 0.089 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.186032e-01 | 0.087 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.243121e-01 | 0.084 |
| R-HSA-5357801 | Programmed Cell Death | 8.325429e-01 | 0.080 |
| R-HSA-397014 | Muscle contraction | 8.416630e-01 | 0.075 |
| R-HSA-68882 | Mitotic Anaphase | 8.466515e-01 | 0.072 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.478740e-01 | 0.072 |
| R-HSA-418990 | Adherens junctions interactions | 8.490869e-01 | 0.071 |
| R-HSA-1266738 | Developmental Biology | 8.640116e-01 | 0.063 |
| R-HSA-597592 | Post-translational protein modification | 8.641138e-01 | 0.063 |
| R-HSA-72312 | rRNA processing | 8.650932e-01 | 0.063 |
| R-HSA-421270 | Cell-cell junction organization | 8.841539e-01 | 0.053 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.887091e-01 | 0.051 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.904810e-01 | 0.050 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.922470e-01 | 0.050 |
| R-HSA-6798695 | Neutrophil degranulation | 8.936196e-01 | 0.049 |
| R-HSA-416476 | G alpha (q) signalling events | 8.956305e-01 | 0.048 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.067307e-01 | 0.043 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.089524e-01 | 0.041 |
| R-HSA-9658195 | Leishmania infection | 9.089524e-01 | 0.041 |
| R-HSA-168249 | Innate Immune System | 9.151836e-01 | 0.038 |
| R-HSA-195721 | Signaling by WNT | 9.205855e-01 | 0.036 |
| R-HSA-1474244 | Extracellular matrix organization | 9.391204e-01 | 0.027 |
| R-HSA-168256 | Immune System | 9.419409e-01 | 0.026 |
| R-HSA-388396 | GPCR downstream signalling | 9.529572e-01 | 0.021 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.625043e-01 | 0.017 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.710672e-01 | 0.013 |
| R-HSA-372790 | Signaling by GPCR | 9.717615e-01 | 0.012 |
| R-HSA-72766 | Translation | 9.726643e-01 | 0.012 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.795951e-01 | 0.009 |
| R-HSA-112316 | Neuronal System | 9.800870e-01 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 9.825890e-01 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 9.872234e-01 | 0.006 |
| R-HSA-211859 | Biological oxidations | 9.872793e-01 | 0.006 |
| R-HSA-392499 | Metabolism of proteins | 9.888293e-01 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.941560e-01 | 0.003 |
| R-HSA-1430728 | Metabolism | 9.999989e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AURC |
0.738 | 0.201 | -2 | 0.749 |
SKMLCK |
0.736 | 0.262 | -2 | 0.866 |
CLK3 |
0.735 | 0.208 | 1 | 0.699 |
RSK2 |
0.734 | 0.158 | -3 | 0.779 |
NDR2 |
0.733 | 0.095 | -3 | 0.814 |
RSK4 |
0.729 | 0.163 | -3 | 0.761 |
MSK1 |
0.729 | 0.191 | -3 | 0.747 |
CLK2 |
0.729 | 0.234 | -3 | 0.747 |
HIPK4 |
0.729 | 0.125 | 1 | 0.662 |
PIM3 |
0.729 | 0.125 | -3 | 0.809 |
COT |
0.728 | 0.161 | 2 | 0.385 |
CDC7 |
0.727 | 0.096 | 1 | 0.757 |
P90RSK |
0.726 | 0.127 | -3 | 0.781 |
CAMK2A |
0.726 | 0.160 | 2 | 0.356 |
DYRK4 |
0.724 | 0.166 | 1 | 0.531 |
PRKD2 |
0.723 | 0.110 | -3 | 0.775 |
PKACB |
0.723 | 0.168 | -2 | 0.744 |
PAK1 |
0.723 | 0.141 | -2 | 0.844 |
DYRK2 |
0.722 | 0.125 | 1 | 0.589 |
PRKD1 |
0.722 | 0.078 | -3 | 0.814 |
MTOR |
0.720 | 0.138 | 1 | 0.682 |
MAPKAPK2 |
0.720 | 0.112 | -3 | 0.740 |
RSK3 |
0.720 | 0.102 | -3 | 0.763 |
PKACG |
0.720 | 0.111 | -2 | 0.779 |
PRKX |
0.720 | 0.151 | -3 | 0.705 |
NDR1 |
0.719 | 0.077 | -3 | 0.808 |
PAK6 |
0.719 | 0.128 | -2 | 0.775 |
CAMK1B |
0.719 | 0.125 | -3 | 0.813 |
LATS2 |
0.717 | 0.047 | -5 | 0.486 |
MOS |
0.716 | 0.116 | 1 | 0.752 |
ICK |
0.716 | 0.142 | -3 | 0.817 |
CAMK2D |
0.716 | 0.080 | -3 | 0.810 |
AURB |
0.716 | 0.147 | -2 | 0.747 |
MSK2 |
0.716 | 0.121 | -3 | 0.737 |
SRPK1 |
0.715 | 0.096 | -3 | 0.757 |
PIM1 |
0.715 | 0.101 | -3 | 0.763 |
CDKL1 |
0.715 | 0.103 | -3 | 0.788 |
MAPKAPK3 |
0.714 | 0.081 | -3 | 0.775 |
CAMLCK |
0.714 | 0.152 | -2 | 0.847 |
CLK4 |
0.714 | 0.163 | -3 | 0.754 |
GRK1 |
0.714 | 0.091 | -2 | 0.736 |
CAMK2B |
0.714 | 0.093 | 2 | 0.327 |
CDKL5 |
0.714 | 0.092 | -3 | 0.794 |
RAF1 |
0.714 | 0.117 | 1 | 0.742 |
MNK2 |
0.714 | 0.139 | -2 | 0.818 |
DAPK2 |
0.714 | 0.174 | -3 | 0.823 |
MYLK4 |
0.714 | 0.170 | -2 | 0.813 |
PAK3 |
0.713 | 0.101 | -2 | 0.826 |
P70S6KB |
0.713 | 0.084 | -3 | 0.781 |
HIPK2 |
0.713 | 0.105 | 1 | 0.519 |
IKKB |
0.713 | 0.015 | -2 | 0.680 |
PASK |
0.713 | 0.262 | -3 | 0.818 |
ERK5 |
0.712 | 0.034 | 1 | 0.692 |
PKN2 |
0.712 | 0.089 | -3 | 0.799 |
CLK1 |
0.711 | 0.143 | -3 | 0.742 |
RIPK3 |
0.711 | 0.086 | 3 | 0.646 |
DRAK1 |
0.710 | 0.263 | 1 | 0.797 |
AURA |
0.710 | 0.132 | -2 | 0.737 |
MNK1 |
0.710 | 0.129 | -2 | 0.817 |
NLK |
0.710 | 0.026 | 1 | 0.712 |
WNK1 |
0.710 | 0.065 | -2 | 0.841 |
ATR |
0.709 | 0.023 | 1 | 0.689 |
PKG2 |
0.709 | 0.110 | -2 | 0.739 |
CAMK2G |
0.709 | 0.002 | 2 | 0.328 |
HUNK |
0.708 | 0.081 | 2 | 0.408 |
GRK5 |
0.708 | 0.039 | -3 | 0.734 |
JNK2 |
0.708 | 0.110 | 1 | 0.536 |
PAK4 |
0.707 | 0.125 | -2 | 0.760 |
PAK2 |
0.706 | 0.090 | -2 | 0.827 |
GRK6 |
0.706 | 0.086 | 1 | 0.766 |
SGK3 |
0.706 | 0.102 | -3 | 0.767 |
PKACA |
0.706 | 0.127 | -2 | 0.706 |
PRPK |
0.706 | -0.056 | -1 | 0.689 |
CDK18 |
0.706 | 0.063 | 1 | 0.525 |
TBK1 |
0.706 | -0.036 | 1 | 0.645 |
LATS1 |
0.706 | 0.109 | -3 | 0.831 |
PKN3 |
0.706 | 0.026 | -3 | 0.797 |
NUAK2 |
0.705 | 0.048 | -3 | 0.807 |
CHAK2 |
0.705 | 0.022 | -1 | 0.761 |
PKCA |
0.705 | 0.062 | 2 | 0.252 |
IKKE |
0.705 | -0.025 | 1 | 0.647 |
PDHK4 |
0.705 | -0.077 | 1 | 0.738 |
PKCD |
0.705 | 0.058 | 2 | 0.279 |
AKT2 |
0.704 | 0.119 | -3 | 0.705 |
PKCG |
0.704 | 0.068 | 2 | 0.274 |
HIPK1 |
0.704 | 0.095 | 1 | 0.605 |
NIK |
0.704 | 0.078 | -3 | 0.814 |
CDK7 |
0.704 | 0.040 | 1 | 0.578 |
IKKA |
0.704 | 0.004 | -2 | 0.669 |
GSK3A |
0.703 | 0.117 | 4 | 0.556 |
MAK |
0.703 | 0.187 | -2 | 0.888 |
GRK7 |
0.703 | 0.092 | 1 | 0.710 |
CAMK4 |
0.703 | 0.049 | -3 | 0.778 |
DYRK1A |
0.703 | 0.087 | 1 | 0.616 |
DYRK3 |
0.702 | 0.124 | 1 | 0.601 |
AMPKA1 |
0.702 | 0.008 | -3 | 0.815 |
RIPK1 |
0.701 | 0.040 | 1 | 0.690 |
MST4 |
0.701 | -0.004 | 2 | 0.325 |
P38B |
0.700 | 0.090 | 1 | 0.545 |
PAK5 |
0.700 | 0.107 | -2 | 0.744 |
TSSK1 |
0.700 | 0.042 | -3 | 0.834 |
GSK3B |
0.700 | 0.099 | 4 | 0.551 |
PKCB |
0.700 | 0.042 | 2 | 0.265 |
FAM20C |
0.700 | -0.024 | 2 | 0.237 |
CDK19 |
0.700 | 0.029 | 1 | 0.532 |
CDK8 |
0.700 | 0.016 | 1 | 0.566 |
TSSK2 |
0.700 | 0.047 | -5 | 0.551 |
SRPK2 |
0.699 | 0.055 | -3 | 0.691 |
AMPKA2 |
0.699 | 0.017 | -3 | 0.802 |
P38A |
0.699 | 0.084 | 1 | 0.605 |
PRKD3 |
0.699 | 0.055 | -3 | 0.742 |
MASTL |
0.699 | -0.025 | -2 | 0.738 |
MARK4 |
0.699 | -0.015 | 4 | 0.645 |
DLK |
0.699 | 0.112 | 1 | 0.744 |
KIS |
0.698 | -0.008 | 1 | 0.575 |
DYRK1B |
0.698 | 0.073 | 1 | 0.565 |
CDK14 |
0.698 | 0.065 | 1 | 0.567 |
JNK3 |
0.697 | 0.075 | 1 | 0.558 |
DSTYK |
0.697 | 0.001 | 2 | 0.381 |
CAMK1G |
0.697 | 0.080 | -3 | 0.748 |
CDK1 |
0.697 | 0.058 | 1 | 0.569 |
BRSK1 |
0.697 | 0.023 | -3 | 0.770 |
ULK2 |
0.696 | -0.109 | 2 | 0.287 |
GCN2 |
0.696 | -0.141 | 2 | 0.309 |
BMPR1B |
0.696 | 0.142 | 1 | 0.796 |
PIM2 |
0.696 | 0.068 | -3 | 0.750 |
PKCZ |
0.695 | 0.036 | 2 | 0.280 |
BMPR2 |
0.695 | -0.100 | -2 | 0.762 |
DCAMKL1 |
0.695 | 0.072 | -3 | 0.767 |
CDK10 |
0.694 | 0.067 | 1 | 0.553 |
MLK2 |
0.694 | 0.001 | 2 | 0.305 |
MELK |
0.694 | 0.009 | -3 | 0.795 |
NIM1 |
0.693 | -0.061 | 3 | 0.668 |
NEK6 |
0.693 | -0.060 | -2 | 0.722 |
HIPK3 |
0.693 | 0.066 | 1 | 0.592 |
PDHK1 |
0.693 | -0.173 | 1 | 0.713 |
QSK |
0.692 | 0.012 | 4 | 0.614 |
PLK1 |
0.692 | 0.038 | -2 | 0.654 |
MLK3 |
0.692 | 0.006 | 2 | 0.266 |
GRK4 |
0.692 | -0.044 | -2 | 0.732 |
DAPK1 |
0.692 | 0.160 | -3 | 0.762 |
CDK17 |
0.692 | 0.034 | 1 | 0.489 |
ERK1 |
0.692 | 0.044 | 1 | 0.534 |
TGFBR1 |
0.692 | 0.060 | -2 | 0.646 |
TTBK2 |
0.692 | -0.079 | 2 | 0.271 |
MARK3 |
0.692 | 0.040 | 4 | 0.571 |
PKCH |
0.692 | 0.009 | 2 | 0.254 |
ULK1 |
0.692 | -0.096 | -3 | 0.726 |
CDK13 |
0.691 | 0.009 | 1 | 0.551 |
CDK12 |
0.691 | 0.028 | 1 | 0.529 |
DCAMKL2 |
0.691 | 0.049 | -3 | 0.785 |
DNAPK |
0.691 | 0.032 | 1 | 0.573 |
P38G |
0.691 | 0.044 | 1 | 0.484 |
MLK1 |
0.690 | -0.084 | 2 | 0.313 |
AKT1 |
0.690 | 0.092 | -3 | 0.727 |
GRK2 |
0.690 | 0.076 | -2 | 0.663 |
P70S6K |
0.690 | 0.035 | -3 | 0.720 |
TGFBR2 |
0.690 | -0.060 | -2 | 0.637 |
SRPK3 |
0.690 | 0.032 | -3 | 0.716 |
BCKDK |
0.690 | -0.114 | -1 | 0.648 |
WNK3 |
0.689 | -0.129 | 1 | 0.689 |
SMMLCK |
0.689 | 0.120 | -3 | 0.793 |
AKT3 |
0.689 | 0.112 | -3 | 0.662 |
MAPKAPK5 |
0.689 | 0.001 | -3 | 0.721 |
PLK4 |
0.688 | -0.033 | 2 | 0.272 |
CAMK1D |
0.688 | 0.080 | -3 | 0.693 |
NEK7 |
0.688 | -0.117 | -3 | 0.776 |
MPSK1 |
0.688 | 0.091 | 1 | 0.683 |
BRSK2 |
0.688 | -0.023 | -3 | 0.786 |
CDK9 |
0.687 | 0.004 | 1 | 0.554 |
ALK4 |
0.687 | 0.023 | -2 | 0.678 |
DAPK3 |
0.687 | 0.132 | -3 | 0.777 |
SMG1 |
0.687 | -0.012 | 1 | 0.636 |
PLK3 |
0.687 | 0.017 | 2 | 0.367 |
JNK1 |
0.686 | 0.071 | 1 | 0.535 |
NEK9 |
0.686 | -0.103 | 2 | 0.307 |
SGK1 |
0.686 | 0.094 | -3 | 0.647 |
CHK1 |
0.686 | -0.012 | -3 | 0.791 |
PHKG1 |
0.686 | -0.035 | -3 | 0.792 |
IRE1 |
0.685 | -0.082 | 1 | 0.666 |
NUAK1 |
0.685 | -0.026 | -3 | 0.773 |
QIK |
0.685 | -0.042 | -3 | 0.797 |
CDK3 |
0.685 | 0.041 | 1 | 0.503 |
ATM |
0.684 | -0.035 | 1 | 0.624 |
CDK5 |
0.684 | 0.016 | 1 | 0.594 |
YSK4 |
0.684 | -0.004 | 1 | 0.698 |
NEK2 |
0.684 | -0.035 | 2 | 0.297 |
P38D |
0.684 | 0.049 | 1 | 0.462 |
MEK1 |
0.684 | -0.003 | 2 | 0.372 |
ANKRD3 |
0.683 | -0.083 | 1 | 0.732 |
SNRK |
0.683 | -0.067 | 2 | 0.269 |
CDK16 |
0.683 | 0.030 | 1 | 0.497 |
ERK2 |
0.682 | 0.009 | 1 | 0.575 |
PKCE |
0.682 | 0.050 | 2 | 0.266 |
SIK |
0.682 | -0.020 | -3 | 0.739 |
BUB1 |
0.681 | 0.110 | -5 | 0.553 |
MRCKA |
0.681 | 0.093 | -3 | 0.748 |
MST3 |
0.681 | 0.055 | 2 | 0.359 |
PKR |
0.681 | -0.031 | 1 | 0.710 |
PRP4 |
0.681 | 0.046 | -3 | 0.725 |
VRK2 |
0.680 | -0.067 | 1 | 0.722 |
CK2A2 |
0.680 | 0.075 | 1 | 0.730 |
TLK2 |
0.680 | -0.056 | 1 | 0.682 |
PKCT |
0.680 | 0.016 | 2 | 0.247 |
MOK |
0.680 | 0.106 | 1 | 0.617 |
MRCKB |
0.680 | 0.103 | -3 | 0.739 |
PKCI |
0.680 | 0.023 | 2 | 0.263 |
MARK1 |
0.679 | -0.006 | 4 | 0.579 |
ROCK2 |
0.679 | 0.111 | -3 | 0.779 |
LKB1 |
0.679 | 0.144 | -3 | 0.778 |
CAMK1A |
0.679 | 0.083 | -3 | 0.668 |
MARK2 |
0.679 | -0.036 | 4 | 0.549 |
SSTK |
0.679 | 0.011 | 4 | 0.597 |
CHAK1 |
0.678 | -0.080 | 2 | 0.285 |
CK2A1 |
0.678 | 0.092 | 1 | 0.730 |
ACVR2B |
0.677 | 0.041 | -2 | 0.631 |
GRK3 |
0.677 | 0.043 | -2 | 0.625 |
MLK4 |
0.677 | -0.055 | 2 | 0.257 |
ALK2 |
0.677 | 0.020 | -2 | 0.662 |
CDK2 |
0.677 | -0.003 | 1 | 0.646 |
CHK2 |
0.676 | 0.075 | -3 | 0.658 |
STK33 |
0.676 | 0.015 | 2 | 0.266 |
YANK3 |
0.675 | 0.009 | 2 | 0.199 |
WNK4 |
0.675 | -0.044 | -2 | 0.823 |
ERK7 |
0.675 | -0.023 | 2 | 0.174 |
SBK |
0.674 | 0.079 | -3 | 0.612 |
IRAK4 |
0.674 | -0.034 | 1 | 0.652 |
DMPK1 |
0.674 | 0.136 | -3 | 0.748 |
MEKK3 |
0.673 | -0.024 | 1 | 0.722 |
GCK |
0.673 | 0.120 | 1 | 0.752 |
TTBK1 |
0.673 | -0.093 | 2 | 0.246 |
NEK5 |
0.672 | 0.003 | 1 | 0.696 |
CK1E |
0.672 | -0.023 | -3 | 0.392 |
GAK |
0.672 | 0.091 | 1 | 0.742 |
ACVR2A |
0.672 | 0.001 | -2 | 0.613 |
BMPR1A |
0.671 | 0.060 | 1 | 0.760 |
NEK11 |
0.671 | 0.017 | 1 | 0.708 |
PKN1 |
0.671 | 0.018 | -3 | 0.734 |
MEK5 |
0.671 | -0.078 | 2 | 0.331 |
IRE2 |
0.670 | -0.121 | 2 | 0.250 |
CRIK |
0.670 | 0.078 | -3 | 0.731 |
PDK1 |
0.670 | 0.012 | 1 | 0.671 |
BRAF |
0.670 | -0.018 | -4 | 0.825 |
HPK1 |
0.669 | 0.091 | 1 | 0.738 |
HASPIN |
0.669 | 0.175 | -1 | 0.857 |
PKG1 |
0.669 | 0.060 | -2 | 0.667 |
TAO3 |
0.669 | -0.027 | 1 | 0.713 |
PHKG2 |
0.668 | -0.055 | -3 | 0.768 |
PLK2 |
0.666 | 0.005 | -3 | 0.608 |
CK1A2 |
0.666 | -0.017 | -3 | 0.346 |
CAMKK2 |
0.666 | 0.035 | -2 | 0.711 |
ZAK |
0.666 | -0.096 | 1 | 0.677 |
CAMKK1 |
0.665 | 0.008 | -2 | 0.696 |
PINK1 |
0.664 | -0.090 | 1 | 0.707 |
CDK4 |
0.664 | 0.009 | 1 | 0.519 |
CDK6 |
0.664 | 0.002 | 1 | 0.535 |
TLK1 |
0.663 | -0.092 | -2 | 0.690 |
ROCK1 |
0.663 | 0.085 | -3 | 0.747 |
CK1D |
0.663 | -0.022 | -3 | 0.346 |
CK1G1 |
0.662 | -0.064 | -3 | 0.381 |
LOK |
0.661 | 0.000 | -2 | 0.725 |
MAP3K15 |
0.661 | -0.011 | 1 | 0.662 |
MEKK1 |
0.661 | -0.143 | 1 | 0.679 |
NEK8 |
0.661 | -0.055 | 2 | 0.309 |
NEK4 |
0.661 | -0.024 | 1 | 0.676 |
IRAK1 |
0.660 | -0.130 | -1 | 0.675 |
MEKK2 |
0.660 | -0.122 | 2 | 0.298 |
PBK |
0.660 | 0.024 | 1 | 0.659 |
MEKK6 |
0.660 | -0.026 | 1 | 0.685 |
TAK1 |
0.660 | 0.055 | 1 | 0.724 |
PDHK3_TYR |
0.660 | 0.229 | 4 | 0.741 |
SLK |
0.659 | 0.005 | -2 | 0.671 |
NEK1 |
0.658 | 0.011 | 1 | 0.673 |
KHS1 |
0.658 | 0.035 | 1 | 0.695 |
LRRK2 |
0.658 | -0.023 | 2 | 0.327 |
PERK |
0.658 | -0.170 | -2 | 0.679 |
KHS2 |
0.657 | 0.038 | 1 | 0.724 |
TNIK |
0.656 | 0.001 | 3 | 0.712 |
TAO2 |
0.654 | -0.098 | 2 | 0.313 |
HRI |
0.653 | -0.201 | -2 | 0.700 |
MST2 |
0.653 | -0.030 | 1 | 0.723 |
PDHK4_TYR |
0.652 | 0.208 | 2 | 0.398 |
VRK1 |
0.652 | -0.047 | 2 | 0.348 |
HGK |
0.652 | -0.056 | 3 | 0.720 |
MST1 |
0.651 | -0.003 | 1 | 0.709 |
MINK |
0.650 | -0.056 | 1 | 0.706 |
EEF2K |
0.648 | -0.074 | 3 | 0.677 |
LIMK2_TYR |
0.648 | 0.078 | -3 | 0.837 |
RIPK2 |
0.647 | -0.111 | 1 | 0.643 |
TESK1_TYR |
0.647 | 0.083 | 3 | 0.773 |
MAP2K6_TYR |
0.646 | 0.143 | -1 | 0.680 |
MAP2K4_TYR |
0.645 | 0.085 | -1 | 0.689 |
CK1A |
0.645 | -0.010 | -3 | 0.254 |
MEK2 |
0.645 | -0.098 | 2 | 0.321 |
YSK1 |
0.644 | -0.080 | 2 | 0.287 |
BMPR2_TYR |
0.644 | 0.099 | -1 | 0.661 |
TNK2 |
0.644 | 0.105 | 3 | 0.677 |
PDHK1_TYR |
0.641 | 0.082 | -1 | 0.680 |
MAP2K7_TYR |
0.641 | -0.008 | 2 | 0.358 |
ASK1 |
0.640 | -0.021 | 1 | 0.649 |
EPHA4 |
0.640 | 0.098 | 2 | 0.403 |
EPHB4 |
0.639 | 0.088 | -1 | 0.639 |
PKMYT1_TYR |
0.637 | -0.086 | 3 | 0.750 |
BIKE |
0.637 | 0.002 | 1 | 0.627 |
EPHA6 |
0.637 | 0.051 | -1 | 0.645 |
YANK2 |
0.636 | -0.019 | 2 | 0.189 |
OSR1 |
0.635 | -0.052 | 2 | 0.310 |
MYO3B |
0.635 | -0.044 | 2 | 0.295 |
NEK3 |
0.635 | -0.117 | 1 | 0.625 |
TXK |
0.634 | 0.157 | 1 | 0.783 |
DDR1 |
0.633 | -0.006 | 4 | 0.645 |
SRMS |
0.633 | 0.124 | 1 | 0.748 |
PINK1_TYR |
0.632 | -0.108 | 1 | 0.730 |
TNK1 |
0.631 | 0.032 | 3 | 0.664 |
PTK2B |
0.630 | 0.095 | -1 | 0.617 |
RET |
0.630 | -0.055 | 1 | 0.676 |
AAK1 |
0.629 | 0.028 | 1 | 0.539 |
EPHB1 |
0.629 | 0.056 | 1 | 0.731 |
ITK |
0.629 | 0.103 | -1 | 0.618 |
LIMK1_TYR |
0.629 | -0.112 | 2 | 0.314 |
MERTK |
0.628 | 0.031 | 3 | 0.681 |
TYRO3 |
0.627 | -0.047 | 3 | 0.674 |
EPHB3 |
0.627 | 0.035 | -1 | 0.621 |
EPHA7 |
0.626 | 0.057 | 2 | 0.373 |
AXL |
0.626 | -0.009 | 3 | 0.681 |
EPHA3 |
0.626 | 0.025 | 2 | 0.361 |
TAO1 |
0.625 | -0.106 | 1 | 0.631 |
MST1R |
0.625 | -0.079 | 3 | 0.699 |
MYO3A |
0.625 | -0.095 | 1 | 0.677 |
DDR2 |
0.624 | 0.064 | 3 | 0.650 |
EPHB2 |
0.624 | 0.044 | -1 | 0.610 |
TTK |
0.624 | -0.098 | -2 | 0.674 |
PTK2 |
0.624 | 0.098 | -1 | 0.553 |
CSF1R |
0.623 | -0.035 | 3 | 0.677 |
FGR |
0.623 | -0.029 | 1 | 0.746 |
ALPHAK3 |
0.622 | -0.054 | -1 | 0.583 |
ABL2 |
0.622 | -0.033 | -1 | 0.620 |
BMX |
0.622 | 0.079 | -1 | 0.554 |
YES1 |
0.621 | -0.020 | -1 | 0.658 |
FGFR2 |
0.621 | -0.052 | 3 | 0.716 |
NEK10_TYR |
0.620 | -0.061 | 1 | 0.608 |
FER |
0.620 | -0.066 | 1 | 0.735 |
ROS1 |
0.619 | -0.133 | 3 | 0.639 |
EPHA5 |
0.619 | 0.045 | 2 | 0.389 |
ABL1 |
0.619 | -0.050 | -1 | 0.619 |
STLK3 |
0.617 | -0.109 | 1 | 0.656 |
KIT |
0.617 | -0.025 | 3 | 0.693 |
INSRR |
0.617 | -0.069 | 3 | 0.642 |
JAK2 |
0.617 | -0.160 | 1 | 0.654 |
KDR |
0.617 | -0.053 | 3 | 0.653 |
JAK3 |
0.616 | -0.086 | 1 | 0.667 |
TEK |
0.615 | -0.043 | 3 | 0.635 |
TYK2 |
0.614 | -0.248 | 1 | 0.664 |
MET |
0.614 | -0.032 | 3 | 0.693 |
EPHA1 |
0.614 | -0.025 | 3 | 0.669 |
FGFR3 |
0.613 | -0.034 | 3 | 0.688 |
FYN |
0.612 | 0.025 | -1 | 0.591 |
WEE1_TYR |
0.612 | -0.078 | -1 | 0.641 |
NTRK1 |
0.611 | -0.092 | -1 | 0.629 |
EPHA2 |
0.611 | 0.042 | -1 | 0.560 |
CSK |
0.611 | -0.024 | 2 | 0.367 |
PDGFRB |
0.611 | -0.167 | 3 | 0.687 |
EPHA8 |
0.611 | 0.010 | -1 | 0.588 |
FGFR1 |
0.611 | -0.124 | 3 | 0.669 |
TEC |
0.611 | -0.011 | -1 | 0.583 |
HCK |
0.610 | -0.081 | -1 | 0.619 |
FLT1 |
0.610 | -0.021 | -1 | 0.610 |
JAK1 |
0.610 | -0.120 | 1 | 0.625 |
LTK |
0.609 | -0.104 | 3 | 0.646 |
LCK |
0.609 | -0.046 | -1 | 0.618 |
BTK |
0.608 | -0.078 | -1 | 0.621 |
NTRK3 |
0.608 | -0.061 | -1 | 0.590 |
BLK |
0.607 | -0.024 | -1 | 0.610 |
TNNI3K_TYR |
0.607 | -0.129 | 1 | 0.640 |
PTK6 |
0.607 | -0.151 | -1 | 0.596 |
ALK |
0.606 | -0.120 | 3 | 0.616 |
PDGFRA |
0.606 | -0.194 | 3 | 0.678 |
MATK |
0.605 | -0.041 | -1 | 0.572 |
ERBB2 |
0.605 | -0.085 | 1 | 0.668 |
CK1G3 |
0.605 | -0.068 | -3 | 0.213 |
FGFR4 |
0.604 | -0.031 | -1 | 0.574 |
FLT4 |
0.603 | -0.105 | 3 | 0.654 |
FRK |
0.603 | -0.053 | -1 | 0.627 |
SRC |
0.603 | -0.020 | -1 | 0.597 |
FLT3 |
0.602 | -0.172 | 3 | 0.671 |
SYK |
0.602 | 0.027 | -1 | 0.533 |
EGFR |
0.601 | -0.051 | 1 | 0.587 |
NTRK2 |
0.599 | -0.167 | 3 | 0.648 |
INSR |
0.599 | -0.137 | 3 | 0.615 |
LYN |
0.597 | -0.064 | 3 | 0.615 |
CK1G2 |
0.596 | -0.046 | -3 | 0.299 |
ERBB4 |
0.595 | -0.011 | 1 | 0.623 |
IGF1R |
0.591 | -0.096 | 3 | 0.575 |
FES |
0.591 | -0.026 | -1 | 0.544 |
MUSK |
0.586 | -0.128 | 1 | 0.595 |
ZAP70 |
0.585 | -0.000 | -1 | 0.488 |