Motif 361 (n=185)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S638 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A8CG34 | POM121C | S366 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| E9PAM4 | None | S430 | ochoa | Phosphatidylinositol 4-kinase type 2 (EC 2.7.1.67) | None |
| F8WAN1 | SPECC1L-ADORA2A | S380 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| H7C1W4 | None | S23 | ochoa | Uncharacterized protein | None |
| H7C1W4 | None | S340 | ochoa | Uncharacterized protein | None |
| O14641 | DVL2 | S592 | psp | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14668 | PRRG1 | S156 | ochoa | Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1) | None |
| O15040 | TECPR2 | S408 | ochoa | Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) | Probably plays a role as positive regulator of autophagy. {ECO:0000269|PubMed:23176824}. |
| O15040 | TECPR2 | S410 | ochoa | Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) | Probably plays a role as positive regulator of autophagy. {ECO:0000269|PubMed:23176824}. |
| O15066 | KIF3B | S723 | ochoa | Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed] | Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation (PubMed:32386558). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity). {ECO:0000250|UniProtKB:Q61771, ECO:0000269|PubMed:32386558}. |
| O15075 | DCLK1 | S305 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O15119 | TBX3 | S701 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O15169 | AXIN1 | S575 | ochoa | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| O15265 | ATXN7 | S215 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
| O43426 | SYNJ1 | S1383 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O60239 | SH3BP5 | S416 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
| O60268 | KIAA0513 | S72 | ochoa | Uncharacterized protein KIAA0513 | None |
| O60503 | ADCY9 | S53 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60759 | CYTIP | S310 | ochoa | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. |
| O75044 | SRGAP2 | S424 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75140 | DEPDC5 | S494 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75164 | KDM4A | S514 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O75164 | KDM4A | S516 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O94886 | TMEM63A | S98 | ochoa | Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A) (hTMEM63A) | Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:31587869, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity). {ECO:0000250|UniProtKB:Q91YT8, ECO:0000269|PubMed:30382938, ECO:0000269|PubMed:31587869, ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458, ECO:0000269|PubMed:39716028}. |
| O95243 | MBD4 | S316 | ochoa | Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) | Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}. |
| O95936 | EOMES | S646 | ochoa | Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}. |
| P01275 | GCG | S32 | ochoa | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] | [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
| P07196 | NEFL | S56 | ochoa|psp | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08551}. |
| P07196 | NEFL | S58 | ochoa | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08551}. |
| P08727 | KRT19 | S54 | ochoa | Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19) | Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P0DJJ0 | SRGAP2C | S424 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1) | Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212, ECO:0000269|PubMed:31822692, ECO:0000269|PubMed:34707291}. |
| P0DMP2 | SRGAP2B | S423 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2) | May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692). In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692). {ECO:0000269|PubMed:31822692, ECO:0000305|PubMed:22559944, ECO:0000305|PubMed:31822692}. |
| P11362 | FGFR1 | S447 | ochoa | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
| P15407 | FOSL1 | S251 | ochoa | Fos-related antigen 1 (FRA-1) | None |
| P15408 | FOSL2 | S307 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P21453 | S1PR1 | S351 | ochoa|psp | Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) | G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. {ECO:0000250, ECO:0000269|PubMed:10982820, ECO:0000269|PubMed:11230698, ECO:0000269|PubMed:11583630, ECO:0000269|PubMed:11604399, ECO:0000269|PubMed:19286607, ECO:0000269|PubMed:22344443, ECO:0000269|PubMed:8626678, ECO:0000269|PubMed:9488656}. |
| P23497 | SP100 | S451 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P30414 | NKTR | S406 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30414 | NKTR | Y807 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P35408 | PTGER4 | S377 | psp | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P35414 | APLNR | S343 | ochoa | Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) | G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:11090199, PubMed:22810587, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:11090199, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G-protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy (PubMed:22810587, PubMed:38428423). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587, PubMed:38428423). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). {ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199, ECO:0000269|PubMed:22810587, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936, ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199). {ECO:0000269|PubMed:11090199}. |
| P41219 | PRPH | S48 | ochoa | Peripherin (Neurofilament 4) | Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15322088, PubMed:15446584). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity). {ECO:0000250|UniProtKB:P15331, ECO:0000250|UniProtKB:P21807, ECO:0000269|PubMed:15322088, ECO:0000269|PubMed:15446584}. |
| P41219 | PRPH | S50 | ochoa | Peripherin (Neurofilament 4) | Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15322088, PubMed:15446584). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity). {ECO:0000250|UniProtKB:P15331, ECO:0000250|UniProtKB:P21807, ECO:0000269|PubMed:15322088, ECO:0000269|PubMed:15446584}. |
| P41970 | ELK3 | S241 | ochoa | ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
| P41970 | ELK3 | S243 | ochoa | ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
| P42166 | TMPO | S291 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P47710 | CSN1S1 | S86 | psp | Alpha-S1-casein [Cleaved into: Casoxin-D] | Important role in the capacity of milk to transport calcium phosphate.; FUNCTION: Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors. |
| P48634 | PRRC2A | S1384 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P52179 | MYOM1 | S65 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55197 | MLLT10 | S362 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P98082 | DAB2 | S324 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01484 | ANK2 | S896 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02241 | KIF23 | S714 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q03001 | DST | S7420 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03111 | MLLT1 | S319 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q03111 | MLLT1 | S438 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q03164 | KMT2A | S479 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03431 | PTH1R | S489 | ochoa|psp | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}. |
| Q12791 | KCNMA1 | S1200 | psp | Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo) | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:14523450, PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Possibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic transmission (PubMed:32958651). {ECO:0000269|PubMed:14523450, ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168, ECO:0000269|PubMed:32958651}.; FUNCTION: [Isoform 5]: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). {ECO:0000269|PubMed:7573516, ECO:0000269|PubMed:7877450}. |
| Q13009 | TIAM1 | S58 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13023 | AKAP6 | S1563 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Q13107 | USP4 | S589 | ochoa | Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) | Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16339847, PubMed:16472766, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766, PubMed:30514904). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). Deubiquitinates HAS2 (PubMed:28604766). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (PubMed:30514904). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847). {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:22347420, ECO:0000269|PubMed:25404403, ECO:0000269|PubMed:28604766, ECO:0000269|PubMed:30514904}. |
| Q13428 | TCOF1 | S996 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13796 | SHROOM2 | S150 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13796 | SHROOM2 | S151 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13796 | SHROOM2 | S919 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14011 | CIRBP | S146 | ochoa|psp | Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}. |
| Q14157 | UBAP2L | Y602 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14671 | PUM1 | S797 | ochoa | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
| Q14940 | SLC9A5 | S851 | psp | Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:10692428, PubMed:19276089, PubMed:24936055, PubMed:9933641). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:21551074, PubMed:24006492). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055). {ECO:0000269|PubMed:10692428, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24006492, ECO:0000269|PubMed:24936055, ECO:0000269|PubMed:9933641}. |
| Q15648 | MED1 | S1134 | psp | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15648 | MED1 | S1245 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q16186 | ADRM1 | S211 | ochoa | Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}. |
| Q16537 | PPP2R5E | S30 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q16832 | DDR2 | S459 | ochoa | Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) | Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:30449416, ECO:0000269|PubMed:9659899}. |
| Q2PPJ7 | RALGAPA2 | S764 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q4G0A6 | MINDY4 | S233 | ochoa | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4) | Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000250|UniProtKB:Q8NBR6}. |
| Q5T1R4 | HIVEP3 | S1010 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T200 | ZC3H13 | S1208 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T481 | RBM20 | S654 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5T9C2 | EEIG1 | S249 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5TBA9 | FRY | S2365 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5TH69 | ARFGEF3 | S592 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VT52 | RPRD2 | S1132 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VTL8 | PRPF38B | S471 | ochoa | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | May be required for pre-mRNA splicing. {ECO:0000305}. |
| Q5VTL8 | PRPF38B | S527 | ochoa | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | May be required for pre-mRNA splicing. {ECO:0000305}. |
| Q68CZ2 | TNS3 | S941 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q69YQ0 | SPECC1L | S380 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6PCB5 | RSBN1L | S96 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6PCB5 | RSBN1L | S100 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6PJF5 | RHBDF2 | S385 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6R327 | RICTOR | S1028 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6T4R5 | NHS | S1476 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6UUV7 | CRTC3 | S320 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6ZN18 | AEBP2 | S139 | ochoa | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q6ZNL6 | FGD5 | S699 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q70CQ4 | USP31 | S877 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q70E73 | RAPH1 | S536 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q70EL2 | USP45 | S522 | ochoa | Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45) | Catalyzes the deubiquitination of SPDL1 (PubMed:30258100). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (PubMed:30258100). {ECO:0000250|UniProtKB:E9QG68, ECO:0000269|PubMed:25538220, ECO:0000269|PubMed:30258100, ECO:0000269|PubMed:30573563}. |
| Q7Z2Z1 | TICRR | S834 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z6B7 | SRGAP1 | S1027 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6L1 | TECPR1 | S384 | ochoa | Tectonin beta-propeller repeat-containing protein 1 | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}. |
| Q86SQ4 | ADGRG6 | S1160 | ochoa | Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: Adhesion G-protein coupled receptor G6, N-terminal fragment (ADGRG6 N-terminal fragment) (ADGRG6-NTF); Adhesion G-protein coupled receptor G6, C-terminal fragment (ADGRG6 C-terminal fragment) (ADGRG6-CTF)] | Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP) (PubMed:35394864, PubMed:39884271). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:24227709, PubMed:35394864). ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:24227709, PubMed:35394864). Also able to couple to G(q) G proteins (PubMed:24227709). Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Also acts as a regulator of body length and bone mass (PubMed:18391950). Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1 (By similarity). {ECO:0000250|UniProtKB:Q6F3F9, ECO:0000269|PubMed:18391950, ECO:0000269|PubMed:24227709, ECO:0000269|PubMed:35394864, ECO:0000269|PubMed:39884271}. |
| Q86UU0 | BCL9L | S1051 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86VM9 | ZC3H18 | S599 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86X51 | EZHIP | S361 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86X51 | EZHIP | S443 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86XZ4 | SPATS2 | S382 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IVF2 | AHNAK2 | S278 | ochoa | Protein AHNAK2 | None |
| Q8IVL0 | NAV3 | S273 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
| Q8IYJ3 | SYTL1 | S237 | ochoa | Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) | May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. |
| Q8IZV2 | CMTM8 | S24 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 8 (Chemokine-like factor superfamily member 8) | None |
| Q8IZW8 | TNS4 | S196 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N488 | RYBP | S179 | ochoa | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}. |
| Q8N568 | DCLK2 | S315 | ochoa | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q8N8V4 | ANKS4B | S184 | ochoa | Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp) | As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q8K3X6, ECO:0000269|PubMed:26812018}. |
| Q8N9M5 | TMEM102 | S209 | ochoa | Transmembrane protein 102 (Common beta-chain associated protein) (CBAP) | Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}. |
| Q8NCN4 | RNF169 | S366 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NEM2 | SHCBP1 | S266 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8NEY1 | NAV1 | S303 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFH8 | REPS2 | S459 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8TB72 | PUM2 | S587 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8WTW3 | COG1 | S455 | ochoa | Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) | Required for normal Golgi function. {ECO:0000250}. |
| Q8WVM7 | STAG1 | S1065 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WWQ0 | PHIP | S674 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WXG6 | MADD | S1190 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q8WYB5 | KAT6B | S518 | ochoa | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
| Q8WYB5 | KAT6B | S521 | ochoa | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
| Q8WZ75 | ROBO4 | S891 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92574 | TSC1 | S1038 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92841 | DDX17 | S671 | ochoa | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) | As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:22266867, PubMed:26209609). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:19995069, PubMed:20663877). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:19995069, PubMed:20406972, PubMed:20663877, PubMed:24275493). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}. |
| Q92934 | BAD | S71 | ochoa | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q93075 | TATDN2 | S80 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q93075 | TATDN2 | S397 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q969R2 | OSBP2 | S763 | ochoa|psp | Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) | Binds 7-ketocholesterol (PubMed:11278871). Acts during spermatid development where its function is required prior to the removal of cytoplasm from the sperm head (By similarity). {ECO:0000250|UniProtKB:Q8CF21, ECO:0000269|PubMed:11278871}. |
| Q96CB8 | INTS12 | S425 | ochoa | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}. |
| Q96CB8 | INTS12 | S427 | ochoa | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}. |
| Q96CF2 | CHMP4C | S210 | psp | Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515}. |
| Q96HA1 | POM121 | S389 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96JJ3 | ELMO2 | S501 | ochoa | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:11703939, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:27476657}. |
| Q96RU2 | USP28 | S488 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q9BRK4 | LZTS2 | S220 | psp | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BRL6 | SRSF8 | S191 | ochoa | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}. |
| Q9BSJ6 | PIMREG | S195 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BTU6 | PI4K2A | S460 | ochoa | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}. |
| Q9BVC5 | C2orf49 | S143 | ochoa | Ashwin | None |
| Q9BW04 | SARG | S33 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BW04 | SARG | S129 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BWT7 | CARD10 | S567 | ochoa | Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}. |
| Q9BXF6 | RAB11FIP5 | S278 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXL7 | CARD11 | S556 | psp | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BY89 | KIAA1671 | S1666 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0D2 | CEP295 | S2108 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9H063 | MAF1 | S205 | ochoa | Repressor of RNA polymerase III transcription MAF1 homolog | Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}. |
| Q9H5J8 | TAF1D | S23 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H6A9 | PCNX3 | S704 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H7U1 | CCSER2 | S221 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H8G2 | CAAP1 | S89 | ochoa | Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. |
| Q9H8G2 | CAAP1 | S92 | ochoa | Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. |
| Q9H8N7 | ZNF395 | S447 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9NP61 | ARFGAP3 | S365 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NP61 | ARFGAP3 | S367 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NP61 | ARFGAP3 | S451 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NRA8 | EIF4ENIF1 | S345 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRA8 | EIF4ENIF1 | S347 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRA8 | EIF4ENIF1 | S349 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NUY8 | TBC1D23 | S465 | ochoa | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. |
| Q9NYV4 | CDK12 | S316 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NYV4 | CDK12 | S379 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NYV6 | RRN3 | S633 | ochoa|psp | RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) | Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}. |
| Q9NZN8 | CNOT2 | S61 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
| Q9P265 | DIP2B | S178 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P2Q2 | FRMD4A | S949 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UDT6 | CLIP2 | S202 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UJD0 | RIMS3 | S20 | ochoa | Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) | Regulates synaptic membrane exocytosis. {ECO:0000250}. |
| Q9ULT8 | HECTD1 | S1567 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UPN3 | MACF1 | S31 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UQ35 | SRRM2 | S778 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1727 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2H2 | INPP5F | S905 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y2W1 | THRAP3 | S182 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y5P4 | CERT1 | S373 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| Q9Y5P4 | CERT1 | S375 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| P14866 | HNRNPL | S542 | Sugiyama | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 0.001385 | 2.859 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.001385 | 2.859 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.000609 | 3.215 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.000319 | 3.496 |
| R-HSA-199991 | Membrane Trafficking | 0.002469 | 2.607 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 0.010686 | 1.971 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.010191 | 1.992 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.010191 | 1.992 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.010191 | 1.992 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 0.011617 | 1.935 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.011617 | 1.935 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.013125 | 1.882 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.013125 | 1.882 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.013125 | 1.882 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.013125 | 1.882 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.013125 | 1.882 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.005632 | 2.249 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.011617 | 1.935 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.010391 | 1.983 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.008272 | 2.082 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.004362 | 2.360 |
| R-HSA-4839744 | Signaling by APC mutants | 0.010191 | 1.992 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.011617 | 1.935 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.008873 | 2.052 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.003471 | 2.460 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.005347 | 2.272 |
| R-HSA-68882 | Mitotic Anaphase | 0.014458 | 1.840 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.014763 | 1.831 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.016287 | 1.788 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.015515 | 1.809 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.018126 | 1.742 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.017441 | 1.758 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.018243 | 1.739 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.020974 | 1.678 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.023799 | 1.623 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.025832 | 1.588 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.025832 | 1.588 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.052307 | 1.281 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.052307 | 1.281 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 0.072460 | 1.140 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.101894 | 0.992 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.111497 | 0.953 |
| R-HSA-196025 | Formation of annular gap junctions | 0.111497 | 0.953 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.120998 | 0.917 |
| R-HSA-190873 | Gap junction degradation | 0.120998 | 0.917 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.130398 | 0.885 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.041871 | 1.378 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.148900 | 0.827 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.044402 | 1.353 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.167010 | 0.777 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.057857 | 1.238 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.060698 | 1.217 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.060698 | 1.217 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.184737 | 0.733 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.184737 | 0.733 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.066521 | 1.177 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.066521 | 1.177 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.069499 | 1.158 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.072520 | 1.140 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.075583 | 1.122 |
| R-HSA-4641257 | Degradation of AXIN | 0.081830 | 1.087 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.088230 | 1.054 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.091484 | 1.039 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.101451 | 0.994 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.251971 | 0.599 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.251971 | 0.599 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.136570 | 0.865 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.298752 | 0.525 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.075583 | 1.122 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.252032 | 0.599 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.291162 | 0.536 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.088230 | 1.054 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.036982 | 1.432 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.066521 | 1.177 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.101451 | 0.994 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.027933 | 1.554 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.193459 | 0.713 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.235698 | 0.628 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.202088 | 0.694 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.298752 | 0.525 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.216517 | 0.665 |
| R-HSA-4641258 | Degradation of DVL | 0.081830 | 1.087 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.236208 | 0.627 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.228316 | 0.641 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.151281 | 0.820 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.167010 | 0.777 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.069499 | 1.158 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.193459 | 0.713 |
| R-HSA-9664420 | Killing mechanisms | 0.193459 | 0.713 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.220243 | 0.657 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.212596 | 0.672 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.235698 | 0.628 |
| R-HSA-4086400 | PCP/CE pathway | 0.236208 | 0.627 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.094773 | 1.023 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.111701 | 0.952 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.096700 | 1.015 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.271847 | 0.566 |
| R-HSA-202424 | Downstream TCR signaling | 0.287691 | 0.541 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.319243 | 0.496 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.062438 | 1.205 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.101894 | 0.992 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.111497 | 0.953 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.055064 | 1.259 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.060698 | 1.217 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.081830 | 1.087 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.219073 | 0.659 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.111701 | 0.952 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.132944 | 0.876 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.109163 | 0.962 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.328312 | 0.484 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.200879 | 0.697 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.370344 | 0.431 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.307441 | 0.512 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.369730 | 0.432 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.311151 | 0.507 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.101451 | 0.994 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.068088 | 1.167 |
| R-HSA-9620244 | Long-term potentiation | 0.283491 | 0.547 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.111497 | 0.953 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 0.184737 | 0.733 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.069499 | 1.158 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.298752 | 0.525 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.313690 | 0.503 |
| R-HSA-195721 | Signaling by WNT | 0.129514 | 0.888 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.109163 | 0.962 |
| R-HSA-9909396 | Circadian clock | 0.076552 | 1.116 |
| R-HSA-983189 | Kinesins | 0.166288 | 0.779 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 0.101894 | 0.992 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.055064 | 1.259 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.243878 | 0.613 |
| R-HSA-191859 | snRNP Assembly | 0.162512 | 0.789 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.162512 | 0.789 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.170080 | 0.769 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.335506 | 0.474 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.127687 | 0.894 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.204777 | 0.689 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.363525 | 0.439 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.363525 | 0.439 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.259956 | 0.585 |
| R-HSA-68886 | M Phase | 0.031018 | 1.508 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.033618 | 1.473 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.291162 | 0.536 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.072520 | 1.140 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.040413 | 1.393 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.151281 | 0.820 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.321040 | 0.493 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.342624 | 0.465 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.183554 | 0.736 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.066521 | 1.177 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.321040 | 0.493 |
| R-HSA-9667769 | Acetylcholine inhibits contraction of outer hair cells | 0.082376 | 1.084 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.111497 | 0.953 |
| R-HSA-429947 | Deadenylation of mRNA | 0.041871 | 1.378 |
| R-HSA-418457 | cGMP effects | 0.175921 | 0.755 |
| R-HSA-163615 | PKA activation | 0.219073 | 0.659 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.091484 | 1.039 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.091484 | 1.039 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.094773 | 1.023 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.251971 | 0.599 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.370344 | 0.431 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.370344 | 0.431 |
| R-HSA-3214842 | HDMs demethylate histones | 0.283491 | 0.547 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.363525 | 0.439 |
| R-HSA-190236 | Signaling by FGFR | 0.327086 | 0.485 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.139698 | 0.855 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.213573 | 0.670 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.059297 | 1.227 |
| R-HSA-9610379 | HCMV Late Events | 0.120874 | 0.918 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.210548 | 0.677 |
| R-HSA-9758941 | Gastrulation | 0.106759 | 0.972 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.085011 | 1.071 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.088230 | 1.054 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.115176 | 0.939 |
| R-HSA-9930044 | Nuclear RNA decay | 0.342624 | 0.465 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.342624 | 0.465 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.212596 | 0.672 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.349665 | 0.456 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.216517 | 0.665 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.356632 | 0.448 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.356632 | 0.448 |
| R-HSA-169911 | Regulation of Apoptosis | 0.363525 | 0.439 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.205277 | 0.688 |
| R-HSA-9609646 | HCMV Infection | 0.330339 | 0.481 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.094773 | 1.023 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.173887 | 0.760 |
| R-HSA-418555 | G alpha (s) signalling events | 0.149340 | 0.826 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.170080 | 0.769 |
| R-HSA-8875878 | MET promotes cell motility | 0.085011 | 1.071 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.088230 | 1.054 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.219073 | 0.659 |
| R-HSA-109704 | PI3K Cascade | 0.129342 | 0.888 |
| R-HSA-5673000 | RAF activation | 0.356632 | 0.448 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.287691 | 0.541 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.127189 | 0.896 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.122208 | 0.913 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.334904 | 0.475 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.149753 | 0.825 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.044402 | 1.353 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.261751 | 0.582 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.101894 | 0.992 |
| R-HSA-8854214 | TBC/RABGAPs | 0.104837 | 0.979 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.243878 | 0.613 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.251971 | 0.599 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.055040 | 1.259 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.313690 | 0.503 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.344890 | 0.462 |
| R-HSA-3214847 | HATs acetylate histones | 0.330998 | 0.480 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.102643 | 0.989 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.186235 | 0.730 |
| R-HSA-1640170 | Cell Cycle | 0.259410 | 0.586 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.101894 | 0.992 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.243878 | 0.613 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.216517 | 0.665 |
| R-HSA-68875 | Mitotic Prophase | 0.175575 | 0.756 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.139876 | 0.854 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.167698 | 0.775 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.054901 | 1.260 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.139698 | 0.855 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.039397 | 1.405 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.158003 | 0.801 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.219073 | 0.659 |
| R-HSA-112399 | IRS-mediated signalling | 0.155007 | 0.810 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.298752 | 0.525 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.321040 | 0.493 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.349665 | 0.456 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.084027 | 1.076 |
| R-HSA-5688426 | Deubiquitination | 0.077668 | 1.110 |
| R-HSA-1483255 | PI Metabolism | 0.122954 | 0.910 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.162512 | 0.789 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.244114 | 0.612 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.356632 | 0.448 |
| R-HSA-4839726 | Chromatin organization | 0.165078 | 0.782 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.042880 | 1.368 |
| R-HSA-445144 | Signal transduction by L1 | 0.235698 | 0.628 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.291162 | 0.536 |
| R-HSA-70171 | Glycolysis | 0.334904 | 0.475 |
| R-HSA-75893 | TNF signaling | 0.032336 | 1.490 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.170080 | 0.769 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.342624 | 0.465 |
| R-HSA-162582 | Signal Transduction | 0.069336 | 1.159 |
| R-HSA-9707616 | Heme signaling | 0.173887 | 0.760 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.298752 | 0.525 |
| R-HSA-9733709 | Cardiogenesis | 0.342624 | 0.465 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.036982 | 1.432 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.259978 | 0.585 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.291162 | 0.536 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.342697 | 0.465 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.170080 | 0.769 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.235698 | 0.628 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.319243 | 0.496 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.239788 | 0.620 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.125237 | 0.902 |
| R-HSA-418346 | Platelet homeostasis | 0.362047 | 0.441 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.224378 | 0.649 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.248072 | 0.605 |
| R-HSA-8939211 | ESR-mediated signaling | 0.298974 | 0.524 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.253745 | 0.596 |
| R-HSA-73887 | Death Receptor Signaling | 0.039085 | 1.408 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.181541 | 0.741 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.350460 | 0.455 |
| R-HSA-162906 | HIV Infection | 0.128745 | 0.890 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.349665 | 0.456 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.356632 | 0.448 |
| R-HSA-9675108 | Nervous system development | 0.322576 | 0.491 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.210626 | 0.676 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.185386 | 0.732 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.095069 | 1.022 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.217256 | 0.663 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.359852 | 0.444 |
| R-HSA-5357801 | Programmed Cell Death | 0.224023 | 0.650 |
| R-HSA-111933 | Calmodulin induced events | 0.370344 | 0.431 |
| R-HSA-5620971 | Pyroptosis | 0.052321 | 1.281 |
| R-HSA-111997 | CaM pathway | 0.370344 | 0.431 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.181541 | 0.741 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.330998 | 0.480 |
| R-HSA-6806834 | Signaling by MET | 0.244114 | 0.612 |
| R-HSA-72306 | tRNA processing | 0.331622 | 0.479 |
| R-HSA-162587 | HIV Life Cycle | 0.120874 | 0.918 |
| R-HSA-2028269 | Signaling by Hippo | 0.210626 | 0.676 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.370344 | 0.431 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.299551 | 0.524 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.036982 | 1.432 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.342624 | 0.465 |
| R-HSA-9612973 | Autophagy | 0.287815 | 0.541 |
| R-HSA-211000 | Gene Silencing by RNA | 0.365893 | 0.437 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.155007 | 0.810 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.271847 | 0.566 |
| R-HSA-1632852 | Macroautophagy | 0.241706 | 0.617 |
| R-HSA-5218859 | Regulated Necrosis | 0.196991 | 0.706 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.295600 | 0.529 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.158751 | 0.799 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.372601 | 0.429 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.377090 | 0.424 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.377090 | 0.424 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.377090 | 0.424 |
| R-HSA-202403 | TCR signaling | 0.377376 | 0.423 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.383765 | 0.416 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.390369 | 0.409 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.390369 | 0.409 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.390369 | 0.409 |
| R-HSA-69541 | Stabilization of p53 | 0.390369 | 0.409 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.390369 | 0.409 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.390369 | 0.409 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.392551 | 0.406 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.393821 | 0.405 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.396902 | 0.401 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.396902 | 0.401 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.396902 | 0.401 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.401372 | 0.396 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.403365 | 0.394 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.403365 | 0.394 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.403365 | 0.394 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.403365 | 0.394 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.403365 | 0.394 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.403824 | 0.394 |
| R-HSA-9658195 | Leishmania infection | 0.405470 | 0.392 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.405470 | 0.392 |
| R-HSA-422475 | Axon guidance | 0.406879 | 0.391 |
| R-HSA-373760 | L1CAM interactions | 0.407560 | 0.390 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.409760 | 0.387 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.409760 | 0.387 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.409760 | 0.387 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.409760 | 0.387 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.409760 | 0.387 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.409760 | 0.387 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.409760 | 0.387 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.411284 | 0.386 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.411284 | 0.386 |
| R-HSA-70326 | Glucose metabolism | 0.411284 | 0.386 |
| R-HSA-991365 | Activation of GABAB receptors | 0.416087 | 0.381 |
| R-HSA-977444 | GABA B receptor activation | 0.416087 | 0.381 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.416087 | 0.381 |
| R-HSA-165159 | MTOR signalling | 0.416087 | 0.381 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.416087 | 0.381 |
| R-HSA-73928 | Depyrimidination | 0.416087 | 0.381 |
| R-HSA-111996 | Ca-dependent events | 0.416087 | 0.381 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.418699 | 0.378 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.422346 | 0.374 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.422346 | 0.374 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.424234 | 0.372 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.426066 | 0.371 |
| R-HSA-3371556 | Cellular response to heat stress | 0.426066 | 0.371 |
| R-HSA-190828 | Gap junction trafficking | 0.428538 | 0.368 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.428538 | 0.368 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.428538 | 0.368 |
| R-HSA-9907900 | Proteasome assembly | 0.428538 | 0.368 |
| R-HSA-72172 | mRNA Splicing | 0.432732 | 0.364 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.433386 | 0.363 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.433386 | 0.363 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.434665 | 0.362 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.434665 | 0.362 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.434665 | 0.362 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.434665 | 0.362 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.434665 | 0.362 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.434665 | 0.362 |
| R-HSA-9824272 | Somitogenesis | 0.434665 | 0.362 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.434665 | 0.362 |
| R-HSA-8953854 | Metabolism of RNA | 0.439119 | 0.357 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.440726 | 0.356 |
| R-HSA-194138 | Signaling by VEGF | 0.444270 | 0.352 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.446722 | 0.350 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.446722 | 0.350 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.446722 | 0.350 |
| R-HSA-5620924 | Intraflagellar transport | 0.452655 | 0.344 |
| R-HSA-9634597 | GPER1 signaling | 0.452655 | 0.344 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.452655 | 0.344 |
| R-HSA-425410 | Metal ion SLC transporters | 0.452655 | 0.344 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.458524 | 0.339 |
| R-HSA-9766229 | Degradation of CDH1 | 0.458524 | 0.339 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.458524 | 0.339 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.458524 | 0.339 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.464331 | 0.333 |
| R-HSA-1474165 | Reproduction | 0.465689 | 0.332 |
| R-HSA-9843745 | Adipogenesis | 0.469211 | 0.329 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.470076 | 0.328 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.470076 | 0.328 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.475759 | 0.323 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.475759 | 0.323 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.475759 | 0.323 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.475759 | 0.323 |
| R-HSA-8951664 | Neddylation | 0.479959 | 0.319 |
| R-HSA-1221632 | Meiotic synapsis | 0.481382 | 0.318 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.481382 | 0.318 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.481382 | 0.318 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.481382 | 0.318 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.481382 | 0.318 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.481382 | 0.318 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.481382 | 0.318 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.481382 | 0.318 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.486945 | 0.313 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.486945 | 0.313 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.490055 | 0.310 |
| R-HSA-163685 | Integration of energy metabolism | 0.490055 | 0.310 |
| R-HSA-418597 | G alpha (z) signalling events | 0.492449 | 0.308 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.492449 | 0.308 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.496889 | 0.304 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.497894 | 0.303 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.497894 | 0.303 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.497894 | 0.303 |
| R-HSA-6807070 | PTEN Regulation | 0.500284 | 0.301 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.500284 | 0.301 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.503281 | 0.298 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.504248 | 0.297 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.508610 | 0.294 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.508610 | 0.294 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.513718 | 0.289 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.513883 | 0.289 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.513883 | 0.289 |
| R-HSA-977443 | GABA receptor activation | 0.519099 | 0.285 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.519099 | 0.285 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.519099 | 0.285 |
| R-HSA-351202 | Metabolism of polyamines | 0.519099 | 0.285 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.520346 | 0.284 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.524260 | 0.280 |
| R-HSA-112043 | PLC beta mediated events | 0.524260 | 0.280 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.529365 | 0.276 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.529365 | 0.276 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.529365 | 0.276 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.529365 | 0.276 |
| R-HSA-69242 | S Phase | 0.533421 | 0.273 |
| R-HSA-166520 | Signaling by NTRKs | 0.533421 | 0.273 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.534416 | 0.272 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.534416 | 0.272 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.534416 | 0.272 |
| R-HSA-8848021 | Signaling by PTK6 | 0.534416 | 0.272 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.544358 | 0.264 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.546252 | 0.263 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.548403 | 0.261 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.549249 | 0.260 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.552575 | 0.258 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.552575 | 0.258 |
| R-HSA-112040 | G-protein mediated events | 0.554088 | 0.256 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.554088 | 0.256 |
| R-HSA-1989781 | PPARA activates gene expression | 0.555714 | 0.255 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.555714 | 0.255 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.558875 | 0.253 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.558875 | 0.253 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.561728 | 0.250 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.561944 | 0.250 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.565036 | 0.248 |
| R-HSA-877300 | Interferon gamma signaling | 0.568112 | 0.246 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.568297 | 0.245 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.572932 | 0.242 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.572932 | 0.242 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.572932 | 0.242 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.572932 | 0.242 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.572932 | 0.242 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.572932 | 0.242 |
| R-HSA-109581 | Apoptosis | 0.577247 | 0.239 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.577518 | 0.238 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.577518 | 0.238 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.577518 | 0.238 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.577518 | 0.238 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.582055 | 0.235 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.586544 | 0.232 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.586544 | 0.232 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.590985 | 0.228 |
| R-HSA-5619102 | SLC transporter disorders | 0.592159 | 0.228 |
| R-HSA-5689603 | UCH proteinases | 0.595378 | 0.225 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.599725 | 0.222 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.600571 | 0.221 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.604025 | 0.219 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.604025 | 0.219 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.604025 | 0.219 |
| R-HSA-5619084 | ABC transporter disorders | 0.604025 | 0.219 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.606678 | 0.217 |
| R-HSA-9659379 | Sensory processing of sound | 0.608279 | 0.216 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.608279 | 0.216 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.609535 | 0.215 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.612376 | 0.213 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.612376 | 0.213 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.612487 | 0.213 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.618011 | 0.209 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.618011 | 0.209 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.624845 | 0.204 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.624845 | 0.204 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.628877 | 0.201 |
| R-HSA-168255 | Influenza Infection | 0.629093 | 0.201 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.631722 | 0.199 |
| R-HSA-1500620 | Meiosis | 0.632865 | 0.199 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.632865 | 0.199 |
| R-HSA-913531 | Interferon Signaling | 0.633076 | 0.199 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.636811 | 0.196 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.636811 | 0.196 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.636811 | 0.196 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.636811 | 0.196 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.644577 | 0.191 |
| R-HSA-69275 | G2/M Transition | 0.647885 | 0.189 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.652178 | 0.186 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.653115 | 0.185 |
| R-HSA-73884 | Base Excision Repair | 0.655917 | 0.183 |
| R-HSA-74160 | Gene expression (Transcription) | 0.659113 | 0.181 |
| R-HSA-1483257 | Phospholipid metabolism | 0.659848 | 0.181 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.663391 | 0.178 |
| R-HSA-68877 | Mitotic Prometaphase | 0.665921 | 0.177 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.666898 | 0.176 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.670480 | 0.174 |
| R-HSA-9609690 | HCMV Early Events | 0.673421 | 0.172 |
| R-HSA-1474290 | Collagen formation | 0.674024 | 0.171 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.680998 | 0.167 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.683210 | 0.165 |
| R-HSA-1296071 | Potassium Channels | 0.684430 | 0.165 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.687824 | 0.163 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.687824 | 0.163 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.690393 | 0.161 |
| R-HSA-422356 | Regulation of insulin secretion | 0.691183 | 0.160 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.697792 | 0.156 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.697792 | 0.156 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.701044 | 0.154 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.704261 | 0.152 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.709529 | 0.149 |
| R-HSA-111885 | Opioid Signalling | 0.710592 | 0.148 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.713381 | 0.147 |
| R-HSA-9833110 | RSV-host interactions | 0.713706 | 0.146 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.716788 | 0.145 |
| R-HSA-69239 | Synthesis of DNA | 0.722852 | 0.141 |
| R-HSA-1266738 | Developmental Biology | 0.724019 | 0.140 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.725836 | 0.139 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.728788 | 0.137 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.728788 | 0.137 |
| R-HSA-597592 | Post-translational protein modification | 0.730342 | 0.136 |
| R-HSA-9679506 | SARS-CoV Infections | 0.744337 | 0.128 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.747190 | 0.127 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.748583 | 0.126 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.766941 | 0.115 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.774395 | 0.111 |
| R-HSA-73894 | DNA Repair | 0.777220 | 0.109 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.779232 | 0.108 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.779232 | 0.108 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.779232 | 0.108 |
| R-HSA-69206 | G1/S Transition | 0.779232 | 0.108 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.781612 | 0.107 |
| R-HSA-69481 | G2/M Checkpoints | 0.783966 | 0.106 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.786295 | 0.104 |
| R-HSA-500792 | GPCR ligand binding | 0.787628 | 0.104 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.801448 | 0.096 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.809422 | 0.092 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.810324 | 0.091 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.810627 | 0.091 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.811284 | 0.091 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.812370 | 0.090 |
| R-HSA-1280218 | Adaptive Immune System | 0.815741 | 0.088 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.816397 | 0.088 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.816397 | 0.088 |
| R-HSA-9664407 | Parasite infection | 0.816397 | 0.088 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.817111 | 0.088 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.818378 | 0.087 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.825376 | 0.083 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.829827 | 0.081 |
| R-HSA-446728 | Cell junction organization | 0.831665 | 0.080 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.833102 | 0.079 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.837058 | 0.077 |
| R-HSA-372790 | Signaling by GPCR | 0.837324 | 0.077 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.838818 | 0.076 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.840558 | 0.075 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.840558 | 0.075 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.842280 | 0.075 |
| R-HSA-69306 | DNA Replication | 0.842280 | 0.075 |
| R-HSA-9711097 | Cellular response to starvation | 0.850616 | 0.070 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.853827 | 0.069 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.853827 | 0.069 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.857269 | 0.067 |
| R-HSA-388396 | GPCR downstream signalling | 0.860027 | 0.065 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.874458 | 0.058 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.874458 | 0.058 |
| R-HSA-2262752 | Cellular responses to stress | 0.875317 | 0.058 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.875816 | 0.058 |
| R-HSA-1500931 | Cell-Cell communication | 0.877938 | 0.057 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.885072 | 0.053 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.891013 | 0.050 |
| R-HSA-1474244 | Extracellular matrix organization | 0.892753 | 0.049 |
| R-HSA-5617833 | Cilium Assembly | 0.895655 | 0.048 |
| R-HSA-112316 | Neuronal System | 0.898722 | 0.046 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.902253 | 0.045 |
| R-HSA-428157 | Sphingolipid metabolism | 0.907434 | 0.042 |
| R-HSA-6805567 | Keratinization | 0.913291 | 0.039 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.919660 | 0.036 |
| R-HSA-212436 | Generic Transcription Pathway | 0.922485 | 0.035 |
| R-HSA-418990 | Adherens junctions interactions | 0.923922 | 0.034 |
| R-HSA-157118 | Signaling by NOTCH | 0.940159 | 0.027 |
| R-HSA-418594 | G alpha (i) signalling events | 0.945836 | 0.024 |
| R-HSA-421270 | Cell-cell junction organization | 0.946934 | 0.024 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.953400 | 0.021 |
| R-HSA-416476 | G alpha (q) signalling events | 0.953964 | 0.020 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.965098 | 0.015 |
| R-HSA-9824446 | Viral Infection Pathways | 0.966808 | 0.015 |
| R-HSA-392499 | Metabolism of proteins | 0.971178 | 0.013 |
| R-HSA-449147 | Signaling by Interleukins | 0.971290 | 0.013 |
| R-HSA-109582 | Hemostasis | 0.975474 | 0.011 |
| R-HSA-8957322 | Metabolism of steroids | 0.976145 | 0.010 |
| R-HSA-5663205 | Infectious disease | 0.980459 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.989433 | 0.005 |
| R-HSA-72766 | Translation | 0.992578 | 0.003 |
| R-HSA-6798695 | Neutrophil degranulation | 0.994555 | 0.002 |
| R-HSA-1643685 | Disease | 0.994652 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.995147 | 0.002 |
| R-HSA-168256 | Immune System | 0.998090 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999093 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999205 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999791 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK2 |
0.765 | 0.330 | -3 | 0.763 |
RSK2 |
0.757 | 0.214 | -3 | 0.789 |
CLK3 |
0.756 | 0.272 | 1 | 0.715 |
RSK4 |
0.750 | 0.209 | -3 | 0.768 |
MSK1 |
0.749 | 0.250 | -3 | 0.777 |
AURC |
0.748 | 0.216 | -2 | 0.804 |
CLK4 |
0.747 | 0.243 | -3 | 0.776 |
P90RSK |
0.747 | 0.164 | -3 | 0.796 |
GSK3B |
0.745 | 0.363 | 4 | 0.731 |
COT |
0.745 | 0.158 | 2 | 0.429 |
NDR2 |
0.745 | 0.108 | -3 | 0.834 |
CAMK2A |
0.745 | 0.227 | 2 | 0.394 |
GSK3A |
0.745 | 0.358 | 4 | 0.734 |
CLK1 |
0.744 | 0.216 | -3 | 0.759 |
PIM3 |
0.744 | 0.147 | -3 | 0.828 |
PRKX |
0.744 | 0.217 | -3 | 0.712 |
SKMLCK |
0.742 | 0.221 | -2 | 0.892 |
DYRK4 |
0.742 | 0.206 | 1 | 0.638 |
RSK3 |
0.742 | 0.139 | -3 | 0.789 |
PKACG |
0.741 | 0.170 | -2 | 0.843 |
NDR1 |
0.739 | 0.110 | -3 | 0.835 |
PKACB |
0.738 | 0.193 | -2 | 0.808 |
CDC7 |
0.738 | 0.088 | 1 | 0.704 |
PIM1 |
0.738 | 0.151 | -3 | 0.789 |
SRPK1 |
0.738 | 0.127 | -3 | 0.760 |
PAK1 |
0.737 | 0.168 | -2 | 0.879 |
PRKD2 |
0.737 | 0.099 | -3 | 0.794 |
DYRK2 |
0.737 | 0.149 | 1 | 0.708 |
MSK2 |
0.737 | 0.168 | -3 | 0.762 |
CAMK1B |
0.736 | 0.163 | -3 | 0.839 |
HIPK4 |
0.736 | 0.076 | 1 | 0.764 |
HUNK |
0.736 | 0.162 | 2 | 0.424 |
CAMK2B |
0.735 | 0.171 | 2 | 0.364 |
AURB |
0.735 | 0.185 | -2 | 0.807 |
LATS2 |
0.734 | 0.083 | -5 | 0.789 |
MTOR |
0.734 | 0.133 | 1 | 0.656 |
P70S6KB |
0.733 | 0.132 | -3 | 0.807 |
MYLK4 |
0.733 | 0.200 | -2 | 0.869 |
MNK1 |
0.732 | 0.167 | -2 | 0.888 |
WNK1 |
0.732 | 0.130 | -2 | 0.870 |
DRAK1 |
0.732 | 0.277 | 1 | 0.744 |
MNK2 |
0.731 | 0.144 | -2 | 0.883 |
CAMK2G |
0.731 | 0.119 | 2 | 0.362 |
RIPK3 |
0.730 | 0.111 | 3 | 0.629 |
DYRK3 |
0.730 | 0.179 | 1 | 0.728 |
CAMK1G |
0.729 | 0.152 | -3 | 0.777 |
CAMK2D |
0.729 | 0.108 | -3 | 0.843 |
CAMLCK |
0.729 | 0.160 | -2 | 0.907 |
PAK3 |
0.729 | 0.121 | -2 | 0.880 |
PKN2 |
0.729 | 0.102 | -3 | 0.831 |
PKCG |
0.728 | 0.092 | 2 | 0.342 |
CDKL1 |
0.727 | 0.077 | -3 | 0.805 |
RAF1 |
0.727 | 0.092 | 1 | 0.677 |
NLK |
0.727 | 0.040 | 1 | 0.742 |
MAPKAPK2 |
0.726 | 0.090 | -3 | 0.764 |
MAPKAPK3 |
0.726 | 0.066 | -3 | 0.809 |
PRKD1 |
0.726 | 0.019 | -3 | 0.844 |
PAK6 |
0.726 | 0.126 | -2 | 0.849 |
DAPK2 |
0.726 | 0.164 | -3 | 0.849 |
NUAK2 |
0.726 | 0.078 | -3 | 0.836 |
PKCB |
0.725 | 0.065 | 2 | 0.331 |
PKCD |
0.725 | 0.058 | 2 | 0.343 |
AURA |
0.724 | 0.164 | -2 | 0.788 |
MOS |
0.724 | 0.057 | 1 | 0.719 |
MST4 |
0.724 | 0.048 | 2 | 0.391 |
PASK |
0.724 | 0.311 | -3 | 0.831 |
CDK10 |
0.724 | 0.119 | 1 | 0.641 |
SRPK2 |
0.723 | 0.085 | -3 | 0.705 |
ICK |
0.723 | 0.088 | -3 | 0.834 |
PKACA |
0.723 | 0.159 | -2 | 0.767 |
CAMK4 |
0.723 | 0.087 | -3 | 0.822 |
CDKL5 |
0.723 | 0.039 | -3 | 0.810 |
GRK6 |
0.723 | 0.187 | 1 | 0.709 |
HIPK2 |
0.723 | 0.100 | 1 | 0.649 |
PKCA |
0.723 | 0.049 | 2 | 0.321 |
PKN3 |
0.723 | 0.028 | -3 | 0.842 |
LATS1 |
0.723 | 0.155 | -3 | 0.845 |
RIPK1 |
0.722 | 0.116 | 1 | 0.703 |
PKG2 |
0.722 | 0.119 | -2 | 0.801 |
PAK2 |
0.721 | 0.116 | -2 | 0.875 |
PKCZ |
0.721 | 0.075 | 2 | 0.333 |
NIK |
0.721 | 0.105 | -3 | 0.847 |
PDHK4 |
0.721 | 0.003 | 1 | 0.693 |
SGK3 |
0.721 | 0.116 | -3 | 0.793 |
HIPK1 |
0.721 | 0.113 | 1 | 0.717 |
AKT2 |
0.720 | 0.128 | -3 | 0.717 |
GRK1 |
0.720 | 0.100 | -2 | 0.764 |
PKCH |
0.719 | 0.064 | 2 | 0.318 |
GCN2 |
0.719 | -0.106 | 2 | 0.349 |
PAK4 |
0.719 | 0.144 | -2 | 0.808 |
ERK5 |
0.719 | -0.007 | 1 | 0.702 |
ATR |
0.719 | 0.021 | 1 | 0.695 |
PRPK |
0.718 | -0.082 | -1 | 0.615 |
IKKB |
0.718 | 0.008 | -2 | 0.738 |
AMPKA1 |
0.718 | 0.017 | -3 | 0.850 |
CDK7 |
0.717 | 0.032 | 1 | 0.645 |
JNK2 |
0.717 | 0.114 | 1 | 0.608 |
PIM2 |
0.717 | 0.103 | -3 | 0.771 |
GRK5 |
0.717 | 0.087 | -3 | 0.774 |
DYRK1B |
0.717 | 0.108 | 1 | 0.659 |
CHAK2 |
0.717 | 0.031 | -1 | 0.758 |
CDK18 |
0.716 | 0.054 | 1 | 0.609 |
MARK4 |
0.716 | -0.011 | 4 | 0.536 |
DCAMKL1 |
0.716 | 0.107 | -3 | 0.797 |
DNAPK |
0.716 | 0.094 | 1 | 0.579 |
CDK14 |
0.716 | 0.083 | 1 | 0.645 |
TSSK1 |
0.716 | 0.028 | -3 | 0.868 |
BRSK1 |
0.716 | 0.024 | -3 | 0.805 |
NIM1 |
0.715 | -0.024 | 3 | 0.621 |
FAM20C |
0.715 | 0.012 | 2 | 0.269 |
PAK5 |
0.715 | 0.125 | -2 | 0.802 |
PRKD3 |
0.715 | 0.052 | -3 | 0.761 |
PLK1 |
0.715 | 0.112 | -2 | 0.769 |
AMPKA2 |
0.715 | 0.023 | -3 | 0.832 |
MELK |
0.715 | 0.021 | -3 | 0.826 |
ULK2 |
0.714 | -0.108 | 2 | 0.326 |
PKCI |
0.714 | 0.088 | 2 | 0.326 |
DSTYK |
0.714 | 0.011 | 2 | 0.432 |
DCAMKL2 |
0.714 | 0.085 | -3 | 0.810 |
DLK |
0.713 | 0.146 | 1 | 0.688 |
CDK9 |
0.713 | 0.047 | 1 | 0.628 |
MASTL |
0.713 | -0.022 | -2 | 0.798 |
TSSK2 |
0.713 | 0.024 | -5 | 0.792 |
CDK1 |
0.713 | 0.077 | 1 | 0.647 |
MARK3 |
0.712 | 0.044 | 4 | 0.482 |
SMMLCK |
0.712 | 0.169 | -3 | 0.818 |
TBK1 |
0.712 | -0.091 | 1 | 0.562 |
PKCE |
0.712 | 0.097 | 2 | 0.332 |
P70S6K |
0.712 | 0.085 | -3 | 0.750 |
IKKE |
0.711 | -0.061 | 1 | 0.562 |
WNK3 |
0.711 | -0.080 | 1 | 0.653 |
PLK3 |
0.711 | 0.098 | 2 | 0.385 |
DYRK1A |
0.711 | 0.070 | 1 | 0.680 |
SRPK3 |
0.711 | 0.059 | -3 | 0.731 |
CDK19 |
0.711 | 0.023 | 1 | 0.603 |
ULK1 |
0.711 | -0.060 | -3 | 0.774 |
DAPK1 |
0.711 | 0.209 | -3 | 0.783 |
CDK12 |
0.710 | 0.057 | 1 | 0.605 |
CDK8 |
0.710 | 0.012 | 1 | 0.629 |
CDK13 |
0.710 | 0.038 | 1 | 0.625 |
IRE1 |
0.710 | -0.045 | 1 | 0.700 |
QSK |
0.710 | 0.006 | 4 | 0.502 |
JNK3 |
0.709 | 0.092 | 1 | 0.624 |
CAMK1D |
0.709 | 0.103 | -3 | 0.718 |
QIK |
0.708 | -0.008 | -3 | 0.827 |
NUAK1 |
0.708 | -0.006 | -3 | 0.807 |
BMPR2 |
0.708 | -0.110 | -2 | 0.840 |
CDK17 |
0.708 | 0.041 | 1 | 0.574 |
TGFBR2 |
0.708 | -0.064 | -2 | 0.759 |
SNRK |
0.707 | -0.038 | 2 | 0.298 |
BRSK2 |
0.707 | -0.027 | -3 | 0.823 |
PKR |
0.707 | 0.068 | 1 | 0.721 |
ATM |
0.707 | 0.011 | 1 | 0.636 |
AKT1 |
0.707 | 0.101 | -3 | 0.740 |
PDHK1 |
0.707 | -0.168 | 1 | 0.662 |
MLK1 |
0.707 | -0.061 | 2 | 0.377 |
BMPR1B |
0.707 | 0.130 | 1 | 0.733 |
HIPK3 |
0.707 | 0.066 | 1 | 0.680 |
PKCT |
0.706 | 0.040 | 2 | 0.312 |
P38A |
0.706 | 0.051 | 1 | 0.666 |
CDK2 |
0.706 | 0.032 | 1 | 0.702 |
MLK3 |
0.706 | -0.041 | 2 | 0.336 |
MAPKAPK5 |
0.705 | 0.032 | -3 | 0.770 |
PHKG1 |
0.705 | -0.046 | -3 | 0.825 |
IKKA |
0.705 | -0.022 | -2 | 0.710 |
NEK2 |
0.705 | -0.020 | 2 | 0.339 |
TGFBR1 |
0.705 | 0.079 | -2 | 0.764 |
ERK2 |
0.704 | 0.044 | 1 | 0.643 |
NEK9 |
0.704 | -0.102 | 2 | 0.353 |
NEK6 |
0.704 | -0.108 | -2 | 0.798 |
STK33 |
0.704 | 0.083 | 2 | 0.298 |
SGK1 |
0.704 | 0.122 | -3 | 0.660 |
MRCKA |
0.703 | 0.150 | -3 | 0.774 |
SIK |
0.703 | -0.009 | -3 | 0.773 |
DAPK3 |
0.703 | 0.159 | -3 | 0.798 |
NEK7 |
0.703 | -0.124 | -3 | 0.778 |
P38G |
0.703 | 0.052 | 1 | 0.568 |
ALK4 |
0.703 | 0.053 | -2 | 0.798 |
ANKRD3 |
0.703 | -0.049 | 1 | 0.706 |
CHK1 |
0.703 | 0.003 | -3 | 0.854 |
SMG1 |
0.703 | 0.002 | 1 | 0.655 |
CDK3 |
0.702 | 0.045 | 1 | 0.588 |
MARK1 |
0.702 | 0.008 | 4 | 0.491 |
BCKDK |
0.702 | -0.140 | -1 | 0.569 |
ERK1 |
0.702 | 0.038 | 1 | 0.606 |
CHAK1 |
0.701 | -0.039 | 2 | 0.312 |
MLK2 |
0.701 | -0.110 | 2 | 0.355 |
WNK4 |
0.701 | 0.035 | -2 | 0.857 |
CDK5 |
0.701 | 0.006 | 1 | 0.662 |
MRCKB |
0.701 | 0.133 | -3 | 0.761 |
CDK16 |
0.701 | 0.041 | 1 | 0.580 |
CK2A1 |
0.700 | 0.155 | 1 | 0.653 |
GRK4 |
0.700 | -0.012 | -2 | 0.764 |
P38B |
0.700 | 0.050 | 1 | 0.612 |
ROCK2 |
0.699 | 0.140 | -3 | 0.807 |
MARK2 |
0.699 | -0.031 | 4 | 0.461 |
KIS |
0.699 | -0.017 | 1 | 0.644 |
MEK1 |
0.699 | 0.013 | 2 | 0.398 |
CK2A2 |
0.699 | 0.107 | 1 | 0.656 |
AKT3 |
0.699 | 0.097 | -3 | 0.668 |
TTBK2 |
0.699 | -0.088 | 2 | 0.294 |
MOK |
0.699 | 0.093 | 1 | 0.748 |
GRK7 |
0.699 | 0.088 | 1 | 0.653 |
PLK4 |
0.698 | -0.057 | 2 | 0.284 |
GRK2 |
0.698 | 0.072 | -2 | 0.669 |
MST3 |
0.698 | 0.065 | 2 | 0.414 |
HASPIN |
0.696 | 0.252 | -1 | 0.914 |
MLK4 |
0.696 | -0.060 | 2 | 0.325 |
MAK |
0.696 | 0.094 | -2 | 0.742 |
ALK2 |
0.696 | 0.071 | -2 | 0.775 |
JNK1 |
0.696 | 0.091 | 1 | 0.605 |
GAK |
0.696 | 0.192 | 1 | 0.730 |
YSK4 |
0.696 | -0.018 | 1 | 0.618 |
IRE2 |
0.696 | -0.111 | 2 | 0.303 |
IRAK4 |
0.695 | -0.021 | 1 | 0.671 |
PHKG2 |
0.695 | -0.021 | -3 | 0.800 |
VRK2 |
0.695 | -0.073 | 1 | 0.724 |
SSTK |
0.694 | 0.005 | 4 | 0.489 |
DMPK1 |
0.694 | 0.177 | -3 | 0.761 |
CHK2 |
0.694 | 0.079 | -3 | 0.674 |
CAMK1A |
0.694 | 0.074 | -3 | 0.680 |
ERK7 |
0.693 | -0.022 | 2 | 0.251 |
BUB1 |
0.692 | 0.086 | -5 | 0.766 |
PKN1 |
0.692 | 0.020 | -3 | 0.761 |
TLK2 |
0.691 | -0.046 | 1 | 0.660 |
ACVR2B |
0.691 | 0.050 | -2 | 0.744 |
CDK4 |
0.690 | 0.032 | 1 | 0.600 |
YANK3 |
0.690 | 0.032 | 2 | 0.220 |
PLK2 |
0.689 | 0.081 | -3 | 0.694 |
BMPR1A |
0.689 | 0.090 | 1 | 0.693 |
CRIK |
0.689 | 0.124 | -3 | 0.740 |
MEKK3 |
0.689 | 0.037 | 1 | 0.667 |
ROCK1 |
0.689 | 0.133 | -3 | 0.778 |
P38D |
0.689 | 0.049 | 1 | 0.561 |
NEK5 |
0.688 | -0.036 | 1 | 0.679 |
LKB1 |
0.688 | 0.045 | -3 | 0.811 |
ACVR2A |
0.688 | 0.019 | -2 | 0.733 |
PKG1 |
0.688 | 0.079 | -2 | 0.741 |
MEK5 |
0.688 | -0.058 | 2 | 0.371 |
SBK |
0.687 | 0.077 | -3 | 0.621 |
NEK11 |
0.686 | 0.014 | 1 | 0.656 |
PINK1 |
0.686 | -0.060 | 1 | 0.753 |
PRP4 |
0.686 | 0.016 | -3 | 0.717 |
GCK |
0.686 | 0.096 | 1 | 0.684 |
HPK1 |
0.685 | 0.089 | 1 | 0.677 |
CDK6 |
0.685 | 0.016 | 1 | 0.617 |
CAMKK2 |
0.685 | 0.047 | -2 | 0.776 |
MPSK1 |
0.684 | -0.038 | 1 | 0.707 |
PERK |
0.684 | -0.116 | -2 | 0.784 |
CAMKK1 |
0.683 | 0.019 | -2 | 0.772 |
BRAF |
0.683 | -0.062 | -4 | 0.804 |
GRK3 |
0.682 | 0.054 | -2 | 0.626 |
LRRK2 |
0.682 | 0.049 | 2 | 0.368 |
IRAK1 |
0.681 | -0.098 | -1 | 0.631 |
TAO3 |
0.680 | -0.039 | 1 | 0.653 |
ZAK |
0.680 | -0.116 | 1 | 0.624 |
TLK1 |
0.680 | -0.063 | -2 | 0.751 |
CK1E |
0.680 | -0.025 | -3 | 0.433 |
TTBK1 |
0.680 | -0.092 | 2 | 0.267 |
NEK8 |
0.680 | -0.053 | 2 | 0.359 |
MEKK1 |
0.680 | -0.143 | 1 | 0.641 |
HRI |
0.679 | -0.148 | -2 | 0.794 |
SLK |
0.679 | 0.029 | -2 | 0.735 |
LOK |
0.679 | -0.000 | -2 | 0.805 |
PDK1 |
0.676 | -0.017 | 1 | 0.642 |
NEK4 |
0.676 | -0.063 | 1 | 0.643 |
MEKK2 |
0.675 | -0.128 | 2 | 0.346 |
PBK |
0.674 | 0.021 | 1 | 0.641 |
CK1A2 |
0.674 | -0.003 | -3 | 0.384 |
MEKK6 |
0.673 | -0.069 | 1 | 0.630 |
NEK1 |
0.673 | -0.039 | 1 | 0.652 |
KHS2 |
0.673 | 0.023 | 1 | 0.668 |
TAK1 |
0.673 | 0.047 | 1 | 0.658 |
TAO2 |
0.672 | -0.095 | 2 | 0.362 |
VRK1 |
0.671 | -0.033 | 2 | 0.385 |
CK1G1 |
0.669 | -0.049 | -3 | 0.402 |
KHS1 |
0.669 | -0.018 | 1 | 0.637 |
TNIK |
0.668 | -0.049 | 3 | 0.638 |
PDHK3_TYR |
0.668 | 0.253 | 4 | 0.636 |
RIPK2 |
0.668 | -0.097 | 1 | 0.575 |
MST1 |
0.667 | -0.016 | 1 | 0.639 |
MAP3K15 |
0.666 | -0.097 | 1 | 0.604 |
MST2 |
0.665 | -0.061 | 1 | 0.651 |
CK1D |
0.665 | -0.028 | -3 | 0.379 |
HGK |
0.665 | -0.089 | 3 | 0.643 |
EEF2K |
0.665 | -0.065 | 3 | 0.618 |
YSK1 |
0.664 | -0.080 | 2 | 0.343 |
MINK |
0.663 | -0.081 | 1 | 0.643 |
PDHK4_TYR |
0.663 | 0.243 | 2 | 0.436 |
MEK2 |
0.661 | -0.119 | 2 | 0.346 |
NEK3 |
0.657 | -0.121 | 1 | 0.587 |
BIKE |
0.656 | 0.008 | 1 | 0.637 |
LIMK2_TYR |
0.656 | 0.028 | -3 | 0.859 |
MYO3B |
0.656 | -0.048 | 2 | 0.342 |
MAP2K6_TYR |
0.656 | 0.181 | -1 | 0.621 |
TESK1_TYR |
0.654 | 0.015 | 3 | 0.699 |
BMPR2_TYR |
0.654 | 0.138 | -1 | 0.606 |
MAP2K7_TYR |
0.650 | 0.005 | 2 | 0.392 |
PKMYT1_TYR |
0.650 | -0.060 | 3 | 0.692 |
MAP2K4_TYR |
0.650 | 0.032 | -1 | 0.617 |
YANK2 |
0.650 | 0.001 | 2 | 0.218 |
OSR1 |
0.648 | -0.093 | 2 | 0.361 |
DDR1 |
0.647 | 0.017 | 4 | 0.569 |
PINK1_TYR |
0.646 | -0.038 | 1 | 0.697 |
ASK1 |
0.646 | -0.095 | 1 | 0.588 |
CK1A |
0.645 | -0.006 | -3 | 0.282 |
TTK |
0.645 | -0.100 | -2 | 0.765 |
AAK1 |
0.644 | 0.023 | 1 | 0.563 |
TAO1 |
0.644 | -0.114 | 1 | 0.568 |
MYO3A |
0.644 | -0.099 | 1 | 0.669 |
PDHK1_TYR |
0.644 | 0.039 | -1 | 0.617 |
LIMK1_TYR |
0.644 | -0.089 | 2 | 0.351 |
DDR2 |
0.641 | 0.080 | 3 | 0.585 |
TNK1 |
0.641 | -0.003 | 3 | 0.604 |
TNK2 |
0.640 | 0.012 | 3 | 0.593 |
EPHA4 |
0.639 | 0.049 | 2 | 0.425 |
EPHA6 |
0.638 | -0.032 | -1 | 0.568 |
ALPHAK3 |
0.638 | -0.021 | -1 | 0.537 |
EPHB4 |
0.634 | -0.043 | -1 | 0.545 |
RET |
0.633 | -0.146 | 1 | 0.636 |
SRMS |
0.630 | 0.030 | 1 | 0.676 |
MST1R |
0.630 | -0.181 | 3 | 0.628 |
WEE1_TYR |
0.629 | -0.047 | -1 | 0.554 |
NEK10_TYR |
0.629 | -0.095 | 1 | 0.539 |
STLK3 |
0.628 | -0.153 | 1 | 0.588 |
TXK |
0.628 | 0.024 | 1 | 0.707 |
FGFR2 |
0.628 | -0.083 | 3 | 0.656 |
PTK2B |
0.627 | 0.019 | -1 | 0.502 |
TYRO3 |
0.627 | -0.189 | 3 | 0.599 |
ITK |
0.627 | 0.004 | -1 | 0.517 |
PTK2 |
0.627 | 0.071 | -1 | 0.505 |
YES1 |
0.626 | -0.077 | -1 | 0.549 |
AXL |
0.625 | -0.114 | 3 | 0.609 |
EPHB1 |
0.625 | -0.036 | 1 | 0.656 |
EPHA3 |
0.624 | -0.036 | 2 | 0.385 |
EPHA7 |
0.623 | -0.029 | 2 | 0.397 |
FGR |
0.623 | -0.122 | 1 | 0.689 |
INSRR |
0.623 | -0.111 | 3 | 0.588 |
MERTK |
0.623 | -0.090 | 3 | 0.620 |
CSF1R |
0.623 | -0.169 | 3 | 0.612 |
JAK3 |
0.622 | -0.139 | 1 | 0.614 |
KDR |
0.621 | -0.113 | 3 | 0.602 |
EPHB3 |
0.621 | -0.079 | -1 | 0.519 |
TEK |
0.621 | -0.119 | 3 | 0.570 |
ROS1 |
0.620 | -0.279 | 3 | 0.575 |
EPHB2 |
0.619 | -0.056 | -1 | 0.508 |
ABL2 |
0.619 | -0.144 | -1 | 0.520 |
TYK2 |
0.619 | -0.333 | 1 | 0.616 |
FER |
0.619 | -0.155 | 1 | 0.673 |
FGFR3 |
0.619 | -0.063 | 3 | 0.634 |
BMX |
0.619 | -0.005 | -1 | 0.454 |
EPHA5 |
0.618 | 0.001 | 2 | 0.411 |
FLT1 |
0.618 | -0.034 | -1 | 0.539 |
KIT |
0.618 | -0.103 | 3 | 0.627 |
ABL1 |
0.617 | -0.150 | -1 | 0.512 |
PDGFRB |
0.617 | -0.233 | 3 | 0.616 |
TNNI3K_TYR |
0.616 | -0.185 | 1 | 0.626 |
FLT4 |
0.616 | -0.104 | 3 | 0.629 |
JAK2 |
0.616 | -0.304 | 1 | 0.606 |
TEC |
0.614 | -0.077 | -1 | 0.471 |
CK1G3 |
0.614 | -0.033 | -3 | 0.231 |
NTRK1 |
0.614 | -0.142 | -1 | 0.525 |
FYN |
0.613 | -0.025 | -1 | 0.493 |
EPHA1 |
0.613 | -0.133 | 3 | 0.586 |
FGFR1 |
0.613 | -0.194 | 3 | 0.597 |
MET |
0.612 | -0.124 | 3 | 0.613 |
EPHA8 |
0.610 | -0.048 | -1 | 0.501 |
HCK |
0.610 | -0.181 | -1 | 0.517 |
LTK |
0.610 | -0.177 | 3 | 0.591 |
ERBB2 |
0.609 | -0.128 | 1 | 0.598 |
CSK |
0.609 | -0.071 | 2 | 0.387 |
BLK |
0.609 | -0.097 | -1 | 0.521 |
PTK6 |
0.609 | -0.207 | -1 | 0.474 |
FLT3 |
0.608 | -0.211 | 3 | 0.597 |
EPHA2 |
0.608 | -0.015 | -1 | 0.471 |
BTK |
0.608 | -0.163 | -1 | 0.499 |
PDGFRA |
0.608 | -0.277 | 3 | 0.613 |
JAK1 |
0.607 | -0.235 | 1 | 0.564 |
ALK |
0.606 | -0.227 | 3 | 0.549 |
LCK |
0.606 | -0.157 | -1 | 0.515 |
CK1G2 |
0.605 | -0.007 | -3 | 0.323 |
MATK |
0.605 | -0.090 | -1 | 0.484 |
NTRK2 |
0.603 | -0.225 | 3 | 0.600 |
INSR |
0.602 | -0.195 | 3 | 0.565 |
FRK |
0.602 | -0.141 | -1 | 0.526 |
NTRK3 |
0.602 | -0.154 | -1 | 0.481 |
SRC |
0.601 | -0.079 | -1 | 0.489 |
SYK |
0.601 | 0.005 | -1 | 0.471 |
FGFR4 |
0.600 | -0.081 | -1 | 0.478 |
LYN |
0.598 | -0.138 | 3 | 0.575 |
EGFR |
0.598 | -0.088 | 1 | 0.514 |
ERBB4 |
0.595 | -0.043 | 1 | 0.556 |
IGF1R |
0.595 | -0.138 | 3 | 0.535 |
MUSK |
0.591 | -0.167 | 1 | 0.519 |
FES |
0.587 | -0.088 | -1 | 0.433 |
ZAP70 |
0.573 | -0.056 | -1 | 0.443 |