Motif 36 (n=96)

Position-wise Probabilities
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uniprot genes site source protein function
A5A3E0 POTEF S932 ochoa POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) None
A6H8Y1 BDP1 S1621 ochoa Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}.
A6NKT7 RGPD3 S393 ochoa RanBP2-like and GRIP domain-containing protein 3 None
A6NKT7 RGPD3 S1545 ochoa RanBP2-like and GRIP domain-containing protein 3 None
O14682 ENC1 S406 ochoa Ectoderm-neural cortex protein 1 (ENC-1) (Kelch-like protein 37) (Nuclear matrix protein NRP/B) (p53-induced gene 10 protein) Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. {ECO:0000269|PubMed:19424503}.
O43741 PRKAB2 S184 ochoa 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
O60508 CDC40 S43 ochoa Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}.
O75376 NCOR1 S172 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O94887 FARP2 S410 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
P04637 TP53 S46 psp Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}.
P05023 ATP1A1 S694 ochoa Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}.
P07900 HSP90AA1 S595 ochoa|psp Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}.
P08238 HSP90AB1 S587 ochoa Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
P0DJD0 RGPD1 S1529 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S1537 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P0DMM9 SULT1A3 S253 ochoa Sulfotransferase 1A3 (ST1A3) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase 1A3/1A4) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST) Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs (PubMed:8093002, PubMed:29524394, PubMed:14622112, PubMed:15358107). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779). {ECO:0000269|PubMed:10199779, ECO:0000269|PubMed:14622112, ECO:0000269|PubMed:15358107, ECO:0000269|PubMed:29524394, ECO:0000269|PubMed:8093002}.
P0DMN0 SULT1A4 S253 ochoa Sulfotransferase 1A4 (ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Sulfotransferase 1A3/1A4) Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs (PubMed:15358107, PubMed:29524394). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779). {ECO:0000269|PubMed:10199779, ECO:0000269|PubMed:15358107, ECO:0000269|PubMed:29524394}.
P11441 UBL4A S90 ochoa Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892}.
P13798 APEH S185 ochoa Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}.
P14618 PKM S77 ochoa Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}.
P14635 CCNB1 S126 psp G2/mitotic-specific cyclin-B1 Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}.
P25054 APC S1042 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P30304 CDC25A S261 ochoa M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P30305 CDC25B S160 ochoa M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P30307 CDC25C S214 ochoa|psp M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}.
P42568 MLLT3 S309 ochoa Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}.
P42702 LIFR S927 ochoa Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
P46821 MAP1B S25 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P46821 MAP1B S1406 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P48634 PRRC2A S1306 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P49792 RANBP2 S392 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2520 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50225 SULT1A1 S253 ochoa Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST) Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones (PubMed:12471039, PubMed:16221673, PubMed:21723874, PubMed:22069470, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). Catalyzes the sulfate conjugation of dopamine (PubMed:8093002). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779). {ECO:0000250|UniProtKB:P17988, ECO:0000269|PubMed:10199779, ECO:0000269|PubMed:12471039, ECO:0000269|PubMed:16221673, ECO:0000269|PubMed:21723874, ECO:0000269|PubMed:22069470, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:7834621, ECO:0000269|PubMed:8093002}.
P60709 ACTB S232 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P62736 ACTA2 S234 ochoa Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P63261 ACTG1 S232 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P63267 ACTG2 S233 ochoa Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68032 ACTC1 S234 ochoa Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68133 ACTA1 S234 ochoa Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P82094 TMF1 S112 ochoa TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.
Q02880 TOP2B S1476 ochoa DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
Q03164 KMT2A S2098 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q04759 PRKCQ S685 ochoa Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}.
Q12986 NFX1 S150 ochoa Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.
Q13352 ITGB3BP S46 psp Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3) Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:12244126, ECO:0000269|PubMed:15082778, ECO:0000269|PubMed:15254226, ECO:0000269|PubMed:16622420}.
Q13480 GAB1 S274 ochoa GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}.
Q13522 PPP1R1A S67 ochoa|psp Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1) Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Q13829 TNFAIP1 S278 ochoa|psp BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial) Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}.
Q15120 PDK3 S23 ochoa [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.
Q15697 ZNF174 S266 ochoa Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) Transcriptional repressor. {ECO:0000269|PubMed:7673192}.
Q15772 SPEG S2343 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q1MSJ5 CSPP1 S747 ochoa Centrosome and spindle pole-associated protein 1 May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}.
Q2TAZ0 ATG2A S775 ochoa Autophagy-related protein 2 homolog A Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
Q3T8J9 GON4L S1268 ochoa GON-4-like protein (GON-4 homolog) Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}.
Q53EZ4 CEP55 S425 ochoa|psp Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}.
Q53HL2 CDCA8 S244 ochoa Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}.
Q5T1M5 FKBP15 S1065 ochoa FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.
Q5TAX3 TUT4 S841 ochoa Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}.
Q6PFW1 PPIP5K1 S964 ochoa Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}.
Q6S8J3 POTEE S932 ochoa POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) None
Q6VY07 PACS1 S495 ochoa Phosphofurin acidic cluster sorting protein 1 (PACS-1) Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}.
Q6WCQ1 MPRIP S326 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6ZQN7 SLCO4C1 S26 ochoa Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}.
Q76FK4 NOL8 S660 ochoa Nucleolar protein 8 (Nucleolar protein Nop132) Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}.
Q7L9B9 EEPD1 S247 ochoa Endonuclease/exonuclease/phosphatase family domain-containing protein 1 None
Q7Z3J3 RGPD4 S393 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z3J3 RGPD4 S1545 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q86WW8 COA5 S37 ochoa Cytochrome c oxidase assembly factor 5 Involved in an early step of the mitochondrial complex IV assembly process. {ECO:0000269|PubMed:21457908}.
Q8IWR0 ZC3H7A S316 ochoa Zinc finger CCCH domain-containing protein 7A May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}.
Q8NHV4 NEDD1 S516 ochoa|psp Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
Q8TD26 CHD6 S34 ochoa Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}.
Q8TDB6 DTX3L S221 ochoa E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}.
Q8TEC5 SH3RF2 S112 ochoa E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2) Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19389623, PubMed:19945436). {ECO:0000269|PubMed:19389623, ECO:0000269|PubMed:19945436, ECO:0000269|PubMed:22128169, ECO:0000269|PubMed:24130170}.
Q8WUU5 GATAD1 S235 ochoa GATA zinc finger domain-containing protein 1 (Ocular development-associated gene protein) Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). {ECO:0000269|PubMed:20850016}.
Q8WUY3 PRUNE2 S1803 ochoa Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
Q96KB5 PBK S59 ochoa Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}.
Q9BY77 POLDIP3 S368 ochoa Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}.
Q9BYW2 SETD2 S624 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9H2P0 ADNP S738 ochoa Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}.
Q9H5I5 PIEZO2 S376 ochoa Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}.
Q9H869 YY1AP1 S724 ochoa YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}.
Q9NR48 ASH1L S22 ochoa Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}.
Q9NYF8 BCLAF1 S658 ochoa Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Q9P2K3 RCOR3 S33 ochoa REST corepressor 3 May act as a component of a corepressor complex that represses transcription. {ECO:0000305}.
Q9UKL0 RCOR1 S139 ochoa REST corepressor 1 (Protein CoREST) Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}.
Q9Y2F5 ICE1 S516 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y2J2 EPB41L3 S762 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
Q9Y2W1 THRAP3 S682 ochoa Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.
Q9Y6X0 SETBP1 S611 ochoa SET-binding protein (SEB) None
Q9Y6X2 PIAS3 S431 ochoa E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3) Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:9388184}.
P22314 UBA1 Y845 Sugiyama Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}.
P49585 PCYT1A S174 Sugiyama Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}.
Q13164 MAPK7 S210 Sugiyama Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
Q5S007 LRRK2 S1445 EPSD|PSP|Sugiyama Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}.
Q7KZF4 SND1 S720 Sugiyama Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}.
Q14524 SCN5A S464 PSP Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}.
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reactome_id name p -log10_p
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 3.173367e-07 6.498
R-HSA-156711 Polo-like kinase mediated events 7.665979e-07 6.115
R-HSA-69275 G2/M Transition 2.282407e-06 5.642
R-HSA-453274 Mitotic G2-G2/M phases 2.485739e-06 5.605
R-HSA-9764561 Regulation of CDH1 Function 7.945708e-06 5.100
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 1.721140e-05 4.764
R-HSA-3000171 Non-integrin membrane-ECM interactions 3.107558e-05 4.508
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 4.552138e-05 4.342
R-HSA-156584 Cytosolic sulfonation of small molecules 6.956733e-05 4.158
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 9.832260e-05 4.007
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 1.856561e-04 3.731
R-HSA-69278 Cell Cycle, Mitotic 2.784710e-04 3.555
R-HSA-6804754 Regulation of TP53 Expression 3.901336e-04 3.409
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.387170e-04 3.358
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 4.638477e-04 3.334
R-HSA-9764265 Regulation of CDH1 Expression and Function 4.638477e-04 3.334
R-HSA-9819196 Zygotic genome activation (ZGA) 8.853207e-04 3.053
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 8.971148e-04 3.047
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.244485e-03 2.905
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 1.178327e-03 2.929
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 1.332414e-03 2.875
R-HSA-8863678 Neurodegenerative Diseases 1.332414e-03 2.875
R-HSA-9753281 Paracetamol ADME 1.110168e-03 2.955
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.629340e-03 2.788
R-HSA-418990 Adherens junctions interactions 1.601093e-03 2.796
R-HSA-445095 Interaction between L1 and Ankyrins 1.746408e-03 2.758
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.896210e-03 2.722
R-HSA-1640170 Cell Cycle 2.016539e-03 2.695
R-HSA-5336415 Uptake and function of diphtheria toxin 2.371680e-03 2.625
R-HSA-196025 Formation of annular gap junctions 2.856532e-03 2.544
R-HSA-190873 Gap junction degradation 3.383880e-03 2.471
R-HSA-9834752 Respiratory syncytial virus genome replication 3.383880e-03 2.471
R-HSA-421270 Cell-cell junction organization 3.288266e-03 2.483
R-HSA-8853659 RET signaling 3.671271e-03 2.435
R-HSA-69620 Cell Cycle Checkpoints 3.776466e-03 2.423
R-HSA-68877 Mitotic Prometaphase 4.146049e-03 2.382
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 3.953110e-03 2.403
R-HSA-6802957 Oncogenic MAPK signaling 4.485466e-03 2.348
R-HSA-3214841 PKMTs methylate histone lysines 4.978115e-03 2.303
R-HSA-9645723 Diseases of programmed cell death 5.195678e-03 2.284
R-HSA-446728 Cell junction organization 5.477660e-03 2.261
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 7.054644e-03 2.152
R-HSA-9723907 Loss of Function of TP53 in Cancer 7.054644e-03 2.152
R-HSA-9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability 7.054644e-03 2.152
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 6.636821e-03 2.178
R-HSA-397014 Muscle contraction 6.361387e-03 2.196
R-HSA-422475 Axon guidance 7.080547e-03 2.150
R-HSA-9856651 MITF-M-dependent gene expression 7.101843e-03 2.149
R-HSA-399954 Sema3A PAK dependent Axon repulsion 8.214498e-03 2.085
R-HSA-446353 Cell-extracellular matrix interactions 8.214498e-03 2.085
R-HSA-3247509 Chromatin modifying enzymes 9.679558e-03 2.014
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 1.046222e-02 1.980
R-HSA-9700206 Signaling by ALK in cancer 1.046222e-02 1.980
R-HSA-1500931 Cell-Cell communication 1.021561e-02 1.991
R-HSA-5637810 Constitutive Signaling by EGFRvIII 1.086288e-02 1.964
R-HSA-5637812 Signaling by EGFRvIII in Cancer 1.086288e-02 1.964
R-HSA-9613829 Chaperone Mediated Autophagy 1.181860e-02 1.927
R-HSA-9665348 Signaling by ERBB2 ECD mutants 1.181860e-02 1.927
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 1.087873e-02 1.963
R-HSA-9675108 Nervous system development 1.074789e-02 1.969
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 1.181055e-02 1.928
R-HSA-4839726 Chromatin organization 1.255401e-02 1.901
R-HSA-1227986 Signaling by ERBB2 1.278698e-02 1.893
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1.489689e-02 1.827
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 1.489689e-02 1.827
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 1.383614e-02 1.859
R-HSA-373755 Semaphorin interactions 1.433596e-02 1.844
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 1.489689e-02 1.827
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.591288e-02 1.798
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 1.711972e-02 1.767
R-HSA-69481 G2/M Checkpoints 1.876774e-02 1.727
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 1.714448e-02 1.766
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 1.714448e-02 1.766
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 1.959712e-02 1.708
R-HSA-1266738 Developmental Biology 1.973954e-02 1.705
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 2.023899e-02 1.694
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.023899e-02 1.694
R-HSA-69473 G2/M DNA damage checkpoint 2.089237e-02 1.680
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 2.792394e-02 1.554
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 2.792394e-02 1.554
R-HSA-198765 Signalling to ERK5 2.792394e-02 1.554
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 2.792394e-02 1.554
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 2.792394e-02 1.554
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 2.792394e-02 1.554
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 2.792394e-02 1.554
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 2.792394e-02 1.554
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 2.792394e-02 1.554
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 2.792394e-02 1.554
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 2.792394e-02 1.554
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 2.792394e-02 1.554
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 2.590966e-02 1.587
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.653380e-02 1.576
R-HSA-1643713 Signaling by EGFR in Cancer 2.195617e-02 1.658
R-HSA-1227990 Signaling by ERBB2 in Cancer 2.728700e-02 1.564
R-HSA-9664565 Signaling by ERBB2 KD Mutants 2.590966e-02 1.587
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 2.642774e-02 1.578
R-HSA-8863795 Downregulation of ERBB2 signaling 2.728700e-02 1.564
R-HSA-9659379 Sensory processing of sound 2.433195e-02 1.614
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 2.292158e-02 1.640
R-HSA-9008059 Interleukin-37 signaling 2.728700e-02 1.564
R-HSA-9730414 MITF-M-regulated melanocyte development 2.550293e-02 1.593
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 2.805915e-02 1.552
R-HSA-390522 Striated Muscle Contraction 3.308131e-02 1.480
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 2.963034e-02 1.528
R-HSA-141424 Amplification of signal from the kinetochores 2.963034e-02 1.528
R-HSA-176187 Activation of ATR in response to replication stress 3.159092e-02 1.500
R-HSA-8878171 Transcriptional regulation by RUNX1 3.116624e-02 1.506
R-HSA-70268 Pyruvate metabolism 3.124726e-02 1.505
R-HSA-9679191 Potential therapeutics for SARS 3.204223e-02 1.494
R-HSA-1538133 G0 and Early G1 3.012809e-02 1.521
R-HSA-111465 Apoptotic cleavage of cellular proteins 3.012809e-02 1.521
R-HSA-8865999 MET activates PTPN11 3.478328e-02 1.459
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.614299e-02 1.442
R-HSA-156580 Phase II - Conjugation of compounds 3.756441e-02 1.425
R-HSA-3371511 HSF1 activation 3.771338e-02 1.424
R-HSA-1474244 Extracellular matrix organization 3.920220e-02 1.407
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3.930955e-02 1.406
R-HSA-5689896 Ovarian tumor domain proteases 3.930955e-02 1.406
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 4.159465e-02 1.381
R-HSA-69560 Transcriptional activation of p53 responsive genes 4.159465e-02 1.381
R-HSA-111448 Activation of NOXA and translocation to mitochondria 4.159465e-02 1.381
R-HSA-6806003 Regulation of TP53 Expression and Degradation 4.257750e-02 1.371
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 4.257750e-02 1.371
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 5.507478e-02 1.259
R-HSA-69478 G2/M DNA replication checkpoint 6.174419e-02 1.209
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 6.174419e-02 1.209
R-HSA-8851907 MET activates PI3K/AKT signaling 6.836694e-02 1.165
R-HSA-9028335 Activated NTRK2 signals through PI3K 7.494335e-02 1.125
R-HSA-8875656 MET receptor recycling 7.494335e-02 1.125
R-HSA-8875555 MET activates RAP1 and RAC1 8.795843e-02 1.056
R-HSA-390450 Folding of actin by CCT/TriC 8.795843e-02 1.056
R-HSA-4839744 Signaling by APC mutants 9.439774e-02 1.025
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 9.439774e-02 1.025
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 9.439774e-02 1.025
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 9.439774e-02 1.025
R-HSA-202670 ERKs are inactivated 1.007920e-01 0.997
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.007920e-01 0.997
R-HSA-5339716 Signaling by GSK3beta mutants 1.007920e-01 0.997
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.071415e-01 0.970
R-HSA-3000484 Scavenging by Class F Receptors 1.071415e-01 0.970
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.071415e-01 0.970
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.071415e-01 0.970
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.071415e-01 0.970
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.071415e-01 0.970
R-HSA-205043 NRIF signals cell death from the nucleus 1.197074e-01 0.922
R-HSA-196299 Beta-catenin phosphorylation cascade 1.259245e-01 0.900
R-HSA-180292 GAB1 signalosome 1.503606e-01 0.823
R-HSA-5654710 PI-3K cascade:FGFR3 1.563630e-01 0.806
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 1.563630e-01 0.806
R-HSA-5654720 PI-3K cascade:FGFR4 1.623234e-01 0.790
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.623234e-01 0.790
R-HSA-5654689 PI-3K cascade:FGFR1 1.799553e-01 0.745
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 1.857505e-01 0.731
R-HSA-72187 mRNA 3'-end processing 6.801376e-02 1.167
R-HSA-5654695 PI-3K cascade:FGFR2 1.972193e-01 0.705
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 9.067004e-02 1.043
R-HSA-380259 Loss of Nlp from mitotic centrosomes 9.067004e-02 1.043
R-HSA-8854518 AURKA Activation by TPX2 9.718806e-02 1.012
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.128841e-01 0.947
R-HSA-380287 Centrosome maturation 1.174833e-01 0.930
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.508676e-01 0.821
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.016056e-01 0.993
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1.134465e-01 0.945
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 2.028935e-01 0.693
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.557823e-01 0.807
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.459854e-01 0.836
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1.197074e-01 0.922
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.085280e-01 0.681
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 7.494335e-02 1.125
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 8.147374e-02 1.089
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 1.382284e-01 0.859
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 1.741193e-01 0.759
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1.799553e-01 0.745
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 1.799553e-01 0.745
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 1.320980e-01 0.879
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 1.757291e-01 0.755
R-HSA-8857538 PTK6 promotes HIF1A stabilization 6.174419e-02 1.209
R-HSA-6804760 Regulation of TP53 Activity through Methylation 1.503606e-01 0.823
R-HSA-5674135 MAP2K and MAPK activation 4.766206e-02 1.322
R-HSA-3700989 Transcriptional Regulation by TP53 1.315353e-01 0.881
R-HSA-5633007 Regulation of TP53 Activity 1.328768e-01 0.877
R-HSA-8937144 Aryl hydrocarbon receptor signalling 5.507478e-02 1.259
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 1.799553e-01 0.745
R-HSA-3214815 HDACs deacetylate histones 7.398429e-02 1.131
R-HSA-69615 G1/S DNA Damage Checkpoints 9.067004e-02 1.043
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1.071415e-01 0.970
R-HSA-9656223 Signaling by RAF1 mutants 4.766206e-02 1.322
R-HSA-198753 ERK/MAPK targets 1.682421e-01 0.774
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 5.659583e-02 1.247
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 5.659583e-02 1.247
R-HSA-9649948 Signaling downstream of RAS mutants 5.659583e-02 1.247
R-HSA-69618 Mitotic Spindle Checkpoint 4.481300e-02 1.349
R-HSA-176417 Phosphorylation of Emi1 5.507478e-02 1.259
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 8.795843e-02 1.056
R-HSA-192905 vRNP Assembly 9.439774e-02 1.025
R-HSA-4839735 Signaling by AXIN mutants 1.007920e-01 0.997
R-HSA-4839748 Signaling by AMER1 mutants 1.007920e-01 0.997
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 1.071415e-01 0.970
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.134465e-01 0.945
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.134465e-01 0.945
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 1.320980e-01 0.879
R-HSA-176412 Phosphorylation of the APC/C 1.320980e-01 0.879
R-HSA-350054 Notch-HLH transcription pathway 1.799553e-01 0.745
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 2.085280e-01 0.681
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 1.320980e-01 0.879
R-HSA-6802949 Signaling by RAS mutants 5.659583e-02 1.247
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 1.134465e-01 0.945
R-HSA-1963642 PI3K events in ERBB2 signaling 1.443158e-01 0.841
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 1.623234e-01 0.790
R-HSA-139915 Activation of PUMA and translocation to mitochondria 6.836694e-02 1.165
R-HSA-2980766 Nuclear Envelope Breakdown 7.805493e-02 1.108
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 8.795843e-02 1.056
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 1.007920e-01 0.997
R-HSA-4419969 Depolymerization of the Nuclear Lamina 1.503606e-01 0.823
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 1.915051e-01 0.718
R-HSA-9932451 SWI/SNF chromatin remodelers 1.972193e-01 0.705
R-HSA-9932444 ATP-dependent chromatin remodelers 1.972193e-01 0.705
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.085280e-01 0.681
R-HSA-390466 Chaperonin-mediated protein folding 1.484223e-01 0.829
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 6.174419e-02 1.209
R-HSA-2465910 MASTL Facilitates Mitotic Progression 8.147374e-02 1.089
R-HSA-2514853 Condensation of Prometaphase Chromosomes 1.007920e-01 0.997
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 1.071415e-01 0.970
R-HSA-6811555 PI5P Regulates TP53 Acetylation 1.134465e-01 0.945
R-HSA-113510 E2F mediated regulation of DNA replication 1.563630e-01 0.806
R-HSA-3371571 HSF1-dependent transactivation 6.606111e-02 1.180
R-HSA-429947 Deadenylation of mRNA 1.915051e-01 0.718
R-HSA-445355 Smooth Muscle Contraction 6.998541e-02 1.155
R-HSA-73856 RNA Polymerase II Transcription Termination 8.640048e-02 1.063
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.106027e-01 0.956
R-HSA-2467813 Separation of Sister Chromatids 1.393059e-01 0.856
R-HSA-68886 M Phase 6.735551e-02 1.172
R-HSA-73857 RNA Polymerase II Transcription 1.537014e-01 0.813
R-HSA-4420097 VEGFA-VEGFR2 Pathway 6.432226e-02 1.192
R-HSA-844456 The NLRP3 inflammasome 1.563630e-01 0.806
R-HSA-74160 Gene expression (Transcription) 6.673355e-02 1.176
R-HSA-437239 Recycling pathway of L1 5.844791e-02 1.233
R-HSA-194138 Signaling by VEGF 7.786935e-02 1.109
R-HSA-3371556 Cellular response to heat stress 7.156544e-02 1.145
R-HSA-9613354 Lipophagy 8.147374e-02 1.089
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 1.071415e-01 0.970
R-HSA-9697154 Disorders of Nervous System Development 1.071415e-01 0.970
R-HSA-9005895 Pervasive developmental disorders 1.071415e-01 0.970
R-HSA-5655291 Signaling by FGFR4 in disease 1.197074e-01 0.922
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.197074e-01 0.922
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.259245e-01 0.900
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 1.443158e-01 0.841
R-HSA-3371568 Attenuation phase 4.424842e-02 1.354
R-HSA-190828 Gap junction trafficking 5.295582e-02 1.276
R-HSA-8943724 Regulation of PTEN gene transcription 8.428940e-02 1.074
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 5.523064e-02 1.258
R-HSA-9612973 Autophagy 1.265565e-01 0.898
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 4.893223e-02 1.310
R-HSA-9758274 Regulation of NF-kappa B signaling 1.320980e-01 0.879
R-HSA-9861718 Regulation of pyruvate metabolism 5.659583e-02 1.247
R-HSA-391251 Protein folding 1.632111e-01 0.787
R-HSA-6783589 Interleukin-6 family signaling 1.915051e-01 0.718
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 5.507478e-02 1.259
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 1.134465e-01 0.945
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.197074e-01 0.922
R-HSA-975577 N-Glycan antennae elongation 1.320980e-01 0.879
R-HSA-9675151 Disorders of Developmental Biology 1.382284e-01 0.859
R-HSA-157858 Gap junction trafficking and regulation 6.221429e-02 1.206
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.089052e-01 0.680
R-HSA-8853884 Transcriptional Regulation by VENTX 4.594341e-02 1.338
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 1.857505e-01 0.731
R-HSA-69202 Cyclin E associated events during G1/S transition 1.060779e-01 0.974
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 1.741193e-01 0.759
R-HSA-5655332 Signaling by FGFR3 in disease 2.085280e-01 0.681
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 1.857505e-01 0.731
R-HSA-5673001 RAF/MAP kinase cascade 1.766484e-01 0.753
R-HSA-70171 Glycolysis 4.481300e-02 1.349
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 1.635398e-01 0.786
R-HSA-5684996 MAPK1/MAPK3 signaling 1.864697e-01 0.729
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 1.563630e-01 0.806
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 5.844791e-02 1.233
R-HSA-879518 Organic anion transport by SLCO transporters 1.857505e-01 0.731
R-HSA-200425 Carnitine shuttle 1.857505e-01 0.731
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 1.387271e-01 0.858
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 2.089052e-01 0.680
R-HSA-68882 Mitotic Anaphase 8.742186e-02 1.058
R-HSA-373760 L1CAM interactions 6.550461e-02 1.184
R-HSA-2555396 Mitotic Metaphase and Anaphase 8.845323e-02 1.053
R-HSA-9816359 Maternal to zygotic transition (MZT) 7.405825e-02 1.130
R-HSA-975871 MyD88 cascade initiated on plasma membrane 1.807791e-01 0.743
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 1.807791e-01 0.743
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 1.807791e-01 0.743
R-HSA-69206 G1/S Transition 7.786935e-02 1.109
R-HSA-975155 MyD88 dependent cascade initiated on endosome 2.114863e-01 0.675
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 2.140706e-01 0.669
R-HSA-211859 Biological oxidations 1.890676e-01 0.723
R-HSA-5688426 Deubiquitination 1.318112e-01 0.880
R-HSA-166166 MyD88-independent TLR4 cascade 2.140706e-01 0.669
R-HSA-9006931 Signaling by Nuclear Receptors 5.542062e-02 1.256
R-HSA-162582 Signal Transduction 8.177717e-02 1.087
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 2.011832e-01 0.696
R-HSA-5218859 Regulated Necrosis 1.016056e-01 0.993
R-HSA-70326 Glucose metabolism 6.669697e-02 1.176
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.591997e-01 0.798
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 1.972193e-01 0.705
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 1.053584e-01 0.977
R-HSA-453279 Mitotic G1 phase and G1/S transition 1.112618e-01 0.954
R-HSA-5696398 Nucleotide Excision Repair 2.011832e-01 0.696
R-HSA-9663891 Selective autophagy 1.508676e-01 0.821
R-HSA-9006115 Signaling by NTRK2 (TRKB) 2.085280e-01 0.681
R-HSA-5357801 Programmed Cell Death 7.647354e-02 1.116
R-HSA-9013694 Signaling by NOTCH4 1.151777e-01 0.939
R-HSA-211000 Gene Silencing by RNA 2.063276e-01 0.685
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 6.361976e-02 1.196
R-HSA-109581 Apoptosis 1.360781e-01 0.866
R-HSA-3928662 EPHB-mediated forward signaling 5.295582e-02 1.276
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 1.707027e-01 0.768
R-HSA-69242 S Phase 1.142606e-01 0.942
R-HSA-2682334 EPH-Ephrin signaling 1.632111e-01 0.787
R-HSA-75153 Apoptotic execution phase 5.659583e-02 1.247
R-HSA-446652 Interleukin-1 family signaling 1.203495e-01 0.920
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 6.032086e-02 1.220
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 9.674726e-02 1.014
R-HSA-449147 Signaling by Interleukins 8.847687e-02 1.053
R-HSA-157118 Signaling by NOTCH 1.137619e-01 0.944
R-HSA-381038 XBP1(S) activates chaperone genes 1.459854e-01 0.836
R-HSA-381070 IRE1alpha activates chaperones 1.607275e-01 0.794
R-HSA-5339562 Uptake and actions of bacterial toxins 6.801376e-02 1.167
R-HSA-9748784 Drug ADME 8.949053e-02 1.048
R-HSA-9619483 Activation of AMPK downstream of NMDARs 2.141230e-01 0.669
R-HSA-5576892 Phase 0 - rapid depolarisation 2.141230e-01 0.669
R-HSA-622312 Inflammasomes 2.141230e-01 0.669
R-HSA-5620971 Pyroptosis 2.141230e-01 0.669
R-HSA-1483249 Inositol phosphate metabolism 2.192484e-01 0.659
R-HSA-5654708 Downstream signaling of activated FGFR3 2.196787e-01 0.658
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 2.196787e-01 0.658
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 2.196787e-01 0.658
R-HSA-9006335 Signaling by Erythropoietin 2.196787e-01 0.658
R-HSA-1852241 Organelle biogenesis and maintenance 2.214011e-01 0.655
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 2.218414e-01 0.654
R-HSA-9679506 SARS-CoV Infections 2.244194e-01 0.649
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.251956e-01 0.647
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 2.251956e-01 0.647
R-HSA-76046 RNA Polymerase III Transcription Initiation 2.251956e-01 0.647
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 2.251956e-01 0.647
R-HSA-5654716 Downstream signaling of activated FGFR4 2.251956e-01 0.647
R-HSA-114452 Activation of BH3-only proteins 2.251956e-01 0.647
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 2.251956e-01 0.647
R-HSA-5628897 TP53 Regulates Metabolic Genes 2.296353e-01 0.639
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 2.296353e-01 0.639
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.306738e-01 0.637
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.306738e-01 0.637
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 2.306738e-01 0.637
R-HSA-4791275 Signaling by WNT in cancer 2.361135e-01 0.627
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 2.361135e-01 0.627
R-HSA-1592230 Mitochondrial biogenesis 2.374480e-01 0.624
R-HSA-1855170 IPs transport between nucleus and cytosol 2.415152e-01 0.617
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.415152e-01 0.617
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.415152e-01 0.617
R-HSA-5675482 Regulation of necroptotic cell death 2.415152e-01 0.617
R-HSA-9022692 Regulation of MECP2 expression and activity 2.415152e-01 0.617
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 2.426648e-01 0.615
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 2.426648e-01 0.615
R-HSA-68875 Mitotic Prophase 2.452752e-01 0.610
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.468790e-01 0.608
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 2.468790e-01 0.608
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.468790e-01 0.608
R-HSA-5696394 DNA Damage Recognition in GG-NER 2.468790e-01 0.608
R-HSA-114508 Effects of PIP2 hydrolysis 2.468790e-01 0.608
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 2.468790e-01 0.608
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 2.504995e-01 0.601
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 2.504995e-01 0.601
R-HSA-6798695 Neutrophil degranulation 2.510943e-01 0.600
R-HSA-203615 eNOS activation 2.522052e-01 0.598
R-HSA-180746 Nuclear import of Rev protein 2.522052e-01 0.598
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 2.522052e-01 0.598
R-HSA-1428517 Aerobic respiration and respiratory electron transport 2.532833e-01 0.596
R-HSA-162909 Host Interactions of HIV factors 2.557274e-01 0.592
R-HSA-9705683 SARS-CoV-2-host interactions 2.570341e-01 0.590
R-HSA-5654696 Downstream signaling of activated FGFR2 2.574940e-01 0.589
R-HSA-5654687 Downstream signaling of activated FGFR1 2.574940e-01 0.589
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 2.574940e-01 0.589
R-HSA-2559585 Oncogene Induced Senescence 2.574940e-01 0.589
R-HSA-5683057 MAPK family signaling cascades 2.625713e-01 0.581
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 2.627458e-01 0.580
R-HSA-74158 RNA Polymerase III Transcription 2.627458e-01 0.580
R-HSA-6804757 Regulation of TP53 Degradation 2.627458e-01 0.580
R-HSA-69205 G1/S-Specific Transcription 2.627458e-01 0.580
R-HSA-9694516 SARS-CoV-2 Infection 2.656824e-01 0.576
R-HSA-180910 Vpr-mediated nuclear import of PICs 2.679607e-01 0.572
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 2.679607e-01 0.572
R-HSA-8875878 MET promotes cell motility 2.731391e-01 0.564
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 2.731391e-01 0.564
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 2.731391e-01 0.564
R-HSA-5213460 RIPK1-mediated regulated necrosis 2.731391e-01 0.564
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 2.782812e-01 0.556
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 2.782812e-01 0.556
R-HSA-69541 Stabilization of p53 2.782812e-01 0.556
R-HSA-168276 NS1 Mediated Effects on Host Pathways 2.782812e-01 0.556
R-HSA-9648002 RAS processing 2.782812e-01 0.556
R-HSA-9843745 Adipogenesis 2.792670e-01 0.554
R-HSA-5576891 Cardiac conduction 2.792670e-01 0.554
R-HSA-9909396 Circadian clock 2.818814e-01 0.550
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 2.833872e-01 0.548
R-HSA-177243 Interactions of Rev with host cellular proteins 2.833872e-01 0.548
R-HSA-176033 Interactions of Vpr with host cellular proteins 2.833872e-01 0.548
R-HSA-1251985 Nuclear signaling by ERBB4 2.833872e-01 0.548
R-HSA-9646399 Aggrephagy 2.833872e-01 0.548
R-HSA-5696395 Formation of Incision Complex in GG-NER 2.833872e-01 0.548
R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi 2.833872e-01 0.548
R-HSA-5218920 VEGFR2 mediated vascular permeability 2.884574e-01 0.540
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 2.884574e-01 0.540
R-HSA-9694548 Maturation of spike protein 2.884574e-01 0.540
R-HSA-5655302 Signaling by FGFR1 in disease 2.934920e-01 0.532
R-HSA-9018519 Estrogen-dependent gene expression 2.949406e-01 0.530
R-HSA-165159 MTOR signalling 2.984913e-01 0.525
R-HSA-6807070 PTEN Regulation 3.027618e-01 0.519
R-HSA-381119 Unfolded Protein Response (UPR) 3.027618e-01 0.519
R-HSA-5654743 Signaling by FGFR4 3.034556e-01 0.518
R-HSA-9664417 Leishmania phagocytosis 3.053658e-01 0.515
R-HSA-9664422 FCGR3A-mediated phagocytosis 3.053658e-01 0.515
R-HSA-9664407 Parasite infection 3.053658e-01 0.515
R-HSA-1632852 Macroautophagy 3.079681e-01 0.511
R-HSA-373752 Netrin-1 signaling 3.083850e-01 0.511
R-HSA-774815 Nucleosome assembly 3.132798e-01 0.504
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 3.132798e-01 0.504
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 3.132798e-01 0.504
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 3.132798e-01 0.504
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 3.132798e-01 0.504
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 3.132798e-01 0.504
R-HSA-5654741 Signaling by FGFR3 3.132798e-01 0.504
R-HSA-2262752 Cellular responses to stress 3.152757e-01 0.501
R-HSA-8856828 Clathrin-mediated endocytosis 3.157638e-01 0.501
R-HSA-2299718 Condensation of Prophase Chromosomes 3.181404e-01 0.497
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 3.181404e-01 0.497
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 3.181404e-01 0.497
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 3.181404e-01 0.497
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 3.181404e-01 0.497
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 3.229668e-01 0.491
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 3.229668e-01 0.491
R-HSA-1483191 Synthesis of PC 3.229668e-01 0.491
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 3.287131e-01 0.483
R-HSA-166520 Signaling by NTRKs 3.287131e-01 0.483
R-HSA-69563 p53-Dependent G1 DNA Damage Response 3.325182e-01 0.478
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 3.325182e-01 0.478
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 3.325182e-01 0.478
R-HSA-109704 PI3K Cascade 3.372437e-01 0.472
R-HSA-5655253 Signaling by FGFR2 in disease 3.372437e-01 0.472
R-HSA-9864848 Complex IV assembly 3.419361e-01 0.466
R-HSA-2514856 The phototransduction cascade 3.419361e-01 0.466
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 3.441658e-01 0.463
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.441658e-01 0.463
R-HSA-112382 Formation of RNA Pol II elongation complex 3.465955e-01 0.460
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 3.465955e-01 0.460
R-HSA-6794361 Neurexins and neuroligins 3.465955e-01 0.460
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.467308e-01 0.460
R-HSA-1989781 PPARA activates gene expression 3.467308e-01 0.460
R-HSA-75955 RNA Polymerase II Transcription Elongation 3.512222e-01 0.454
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.512222e-01 0.454
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 3.518512e-01 0.454
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 3.551782e-01 0.450
R-HSA-9824443 Parasitic Infection Pathways 3.590343e-01 0.445
R-HSA-9658195 Leishmania infection 3.590343e-01 0.445
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 3.603784e-01 0.443
R-HSA-418597 G alpha (z) signalling events 3.603784e-01 0.443
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 3.649084e-01 0.438
R-HSA-177929 Signaling by EGFR 3.649084e-01 0.438
R-HSA-5654736 Signaling by FGFR1 3.649084e-01 0.438
R-HSA-5578775 Ion homeostasis 3.649084e-01 0.438
R-HSA-109606 Intrinsic Pathway for Apoptosis 3.649084e-01 0.438
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 3.649084e-01 0.438
R-HSA-112399 IRS-mediated signalling 3.694066e-01 0.432
R-HSA-1280215 Cytokine Signaling in Immune system 3.715809e-01 0.430
R-HSA-191859 snRNP Assembly 3.783084e-01 0.422
R-HSA-194441 Metabolism of non-coding RNA 3.783084e-01 0.422
R-HSA-429914 Deadenylation-dependent mRNA decay 3.783084e-01 0.422
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 3.783084e-01 0.422
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 3.827124e-01 0.417
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 3.827124e-01 0.417
R-HSA-5362517 Signaling by Retinoic Acid 3.827124e-01 0.417
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 3.827124e-01 0.417
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 3.827124e-01 0.417
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 3.827124e-01 0.417
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 3.827124e-01 0.417
R-HSA-2644603 Signaling by NOTCH1 in Cancer 3.827124e-01 0.417
R-HSA-1257604 PIP3 activates AKT signaling 3.859268e-01 0.413
R-HSA-168325 Viral Messenger RNA Synthesis 3.870856e-01 0.412
R-HSA-450294 MAP kinase activation 3.870856e-01 0.412
R-HSA-2428928 IRS-related events triggered by IGF1R 3.870856e-01 0.412
R-HSA-9707616 Heme signaling 3.914280e-01 0.407
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 3.914280e-01 0.407
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 3.914280e-01 0.407
R-HSA-6784531 tRNA processing in the nucleus 3.914280e-01 0.407
R-HSA-9616222 Transcriptional regulation of granulopoiesis 3.914280e-01 0.407
R-HSA-9909648 Regulation of PD-L1(CD274) expression 3.922784e-01 0.406
R-HSA-5689880 Ub-specific processing proteases 3.947697e-01 0.404
R-HSA-8848021 Signaling by PTK6 3.957399e-01 0.403
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 3.957399e-01 0.403
R-HSA-936837 Ion transport by P-type ATPases 4.000216e-01 0.398
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 4.000216e-01 0.398
R-HSA-2428924 IGF1R signaling cascade 4.000216e-01 0.398
R-HSA-74751 Insulin receptor signalling cascade 4.000216e-01 0.398
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 4.042732e-01 0.393
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 4.084949e-01 0.389
R-HSA-168255 Influenza Infection 4.096196e-01 0.388
R-HSA-2559583 Cellular Senescence 4.120778e-01 0.385
R-HSA-5693606 DNA Double Strand Break Response 4.126869e-01 0.384
R-HSA-195253 Degradation of beta-catenin by the destruction complex 4.250872e-01 0.372
R-HSA-448424 Interleukin-17 signaling 4.250872e-01 0.372
R-HSA-9764560 Regulation of CDH1 Gene Transcription 4.250872e-01 0.372
R-HSA-9824446 Viral Infection Pathways 4.258050e-01 0.371
R-HSA-453276 Regulation of mitotic cell cycle 4.291627e-01 0.367
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 4.291627e-01 0.367
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 4.291627e-01 0.367
R-HSA-8978934 Metabolism of cofactors 4.291627e-01 0.367
R-HSA-5578749 Transcriptional regulation by small RNAs 4.332095e-01 0.363
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 4.332095e-01 0.363
R-HSA-5617833 Cilium Assembly 4.363787e-01 0.360
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 4.372279e-01 0.359
R-HSA-212436 Generic Transcription Pathway 4.377080e-01 0.359
R-HSA-168898 Toll-like Receptor Cascades 4.387796e-01 0.358
R-HSA-212165 Epigenetic regulation of gene expression 4.388486e-01 0.358
R-HSA-674695 RNA Polymerase II Pre-transcription Events 4.412181e-01 0.355
R-HSA-1226099 Signaling by FGFR in disease 4.412181e-01 0.355
R-HSA-1236394 Signaling by ERBB4 4.412181e-01 0.355
R-HSA-8953897 Cellular responses to stimuli 4.442376e-01 0.352
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 4.451802e-01 0.351
R-HSA-8852135 Protein ubiquitination 4.451802e-01 0.351
R-HSA-1169408 ISG15 antiviral mechanism 4.451802e-01 0.351
R-HSA-5689603 UCH proteinases 4.491145e-01 0.348
R-HSA-1980143 Signaling by NOTCH1 4.491145e-01 0.348
R-HSA-9609690 HCMV Early Events 4.507013e-01 0.346
R-HSA-9694635 Translation of Structural Proteins 4.530211e-01 0.344
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 4.569002e-01 0.340
R-HSA-383280 Nuclear Receptor transcription pathway 4.569002e-01 0.340
R-HSA-9955298 SLC-mediated transport of organic anions 4.569002e-01 0.340
R-HSA-389948 Co-inhibition by PD-1 4.601366e-01 0.337
R-HSA-1643685 Disease 4.606662e-01 0.337
R-HSA-6806834 Signaling by MET 4.645769e-01 0.333
R-HSA-5654738 Signaling by FGFR2 4.645769e-01 0.333
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.645769e-01 0.333
R-HSA-9833482 PKR-mediated signaling 4.645769e-01 0.333
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 4.683748e-01 0.329
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 4.721460e-01 0.326
R-HSA-9006925 Intracellular signaling by second messengers 4.737985e-01 0.324
R-HSA-9707564 Cytoprotection by HMOX1 4.758907e-01 0.322
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 4.796090e-01 0.319
R-HSA-6794362 Protein-protein interactions at synapses 4.833012e-01 0.316
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 4.869674e-01 0.313
R-HSA-168249 Innate Immune System 4.887519e-01 0.311
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 4.906079e-01 0.309
R-HSA-438064 Post NMDA receptor activation events 4.942227e-01 0.306
R-HSA-202424 Downstream TCR signaling 5.049153e-01 0.297
R-HSA-73894 DNA Repair 5.059916e-01 0.296
R-HSA-1912408 Pre-NOTCH Transcription and Translation 5.084295e-01 0.294
R-HSA-8986944 Transcriptional Regulation by MECP2 5.084295e-01 0.294
R-HSA-74752 Signaling by Insulin receptor 5.153839e-01 0.288
R-HSA-9772573 Late SARS-CoV-2 Infection Events 5.153839e-01 0.288
R-HSA-168256 Immune System 5.161116e-01 0.287
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 5.222407e-01 0.282
R-HSA-162906 HIV Infection 5.234621e-01 0.281
R-HSA-72764 Eukaryotic Translation Termination 5.290013e-01 0.277
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.356671e-01 0.271
R-HSA-8878159 Transcriptional regulation by RUNX3 5.356671e-01 0.271
R-HSA-8957275 Post-translational protein phosphorylation 5.389648e-01 0.268
R-HSA-190236 Signaling by FGFR 5.389648e-01 0.268
R-HSA-193704 p75 NTR receptor-mediated signalling 5.422394e-01 0.266
R-HSA-3214847 HATs acetylate histones 5.422394e-01 0.266
R-HSA-8939211 ESR-mediated signaling 5.448587e-01 0.264
R-HSA-9020702 Interleukin-1 signaling 5.487194e-01 0.261
R-HSA-9009391 Extra-nuclear estrogen signaling 5.487194e-01 0.261
R-HSA-9842860 Regulation of endogenous retroelements 5.519252e-01 0.258
R-HSA-2559580 Oxidative Stress Induced Senescence 5.519252e-01 0.258
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 5.519252e-01 0.258
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 5.519252e-01 0.258
R-HSA-5619507 Activation of HOX genes during differentiation 5.614080e-01 0.251
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 5.614080e-01 0.251
R-HSA-9833110 RSV-host interactions 5.614080e-01 0.251
R-HSA-9609646 HCMV Infection 5.716729e-01 0.243
R-HSA-202403 TCR signaling 5.797806e-01 0.237
R-HSA-388841 Regulation of T cell activation by CD28 family 5.836619e-01 0.234
R-HSA-1912422 Pre-NOTCH Expression and Processing 5.886788e-01 0.230
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 5.945069e-01 0.226
R-HSA-9734767 Developmental Cell Lineages 5.973383e-01 0.224
R-HSA-416476 G alpha (q) signalling events 5.992648e-01 0.222
R-HSA-9711123 Cellular response to chemical stress 6.069020e-01 0.217
R-HSA-2219528 PI3K/AKT Signaling in Cancer 6.087214e-01 0.216
R-HSA-8878166 Transcriptional regulation by RUNX2 6.115045e-01 0.214
R-HSA-73886 Chromosome Maintenance 6.170119e-01 0.210
R-HSA-9759194 Nuclear events mediated by NFE2L2 6.170119e-01 0.210
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 6.224419e-01 0.206
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 6.304441e-01 0.200
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 6.304441e-01 0.200
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 6.304441e-01 0.200
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 6.327711e-01 0.199
R-HSA-187037 Signaling by NTRK1 (TRKA) 6.382782e-01 0.195
R-HSA-199418 Negative regulation of the PI3K/AKT network 6.434092e-01 0.192
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 6.584137e-01 0.182
R-HSA-163685 Integration of energy metabolism 6.632218e-01 0.178
R-HSA-5663205 Infectious disease 6.775654e-01 0.169
R-HSA-162599 Late Phase of HIV Life Cycle 6.796602e-01 0.168
R-HSA-2871837 FCERI mediated NF-kB activation 6.842091e-01 0.165
R-HSA-2187338 Visual phototransduction 6.909126e-01 0.161
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 6.974750e-01 0.156
R-HSA-9755511 KEAP1-NFE2L2 pathway 6.996316e-01 0.155
R-HSA-199991 Membrane Trafficking 7.016875e-01 0.154
R-HSA-9609507 Protein localization 7.038992e-01 0.152
R-HSA-5693532 DNA Double-Strand Break Repair 7.038992e-01 0.152
R-HSA-5653656 Vesicle-mediated transport 7.039084e-01 0.152
R-HSA-73887 Death Receptor Signaling 7.060104e-01 0.151
R-HSA-9610379 HCMV Late Events 7.122550e-01 0.147
R-HSA-162587 HIV Life Cycle 7.122550e-01 0.147
R-HSA-9006936 Signaling by TGFB family members 7.183681e-01 0.144
R-HSA-8953854 Metabolism of RNA 7.302696e-01 0.137
R-HSA-5619102 SLC transporter disorders 7.321358e-01 0.135
R-HSA-72306 tRNA processing 7.397013e-01 0.131
R-HSA-611105 Respiratory electron transport 7.542027e-01 0.123
R-HSA-597592 Post-translational protein modification 7.624800e-01 0.118
R-HSA-201681 TCF dependent signaling in response to WNT 7.628564e-01 0.118
R-HSA-983712 Ion channel transport 7.728429e-01 0.112
R-HSA-72163 mRNA Splicing - Major Pathway 7.808458e-01 0.107
R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.828136e-01 0.106
R-HSA-913531 Interferon Signaling 7.828136e-01 0.106
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 7.900810e-01 0.102
R-HSA-9824439 Bacterial Infection Pathways 7.908427e-01 0.102
R-HSA-948021 Transport to the Golgi and subsequent modification 7.930729e-01 0.101
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 7.945529e-01 0.100
R-HSA-1483206 Glycerophospholipid biosynthesis 7.945529e-01 0.100
R-HSA-72172 mRNA Splicing 7.974816e-01 0.098
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 8.087881e-01 0.092
R-HSA-109582 Hemostasis 8.269401e-01 0.083
R-HSA-5619115 Disorders of transmembrane transporters 8.513339e-01 0.070
R-HSA-112316 Neuronal System 8.641116e-01 0.063
R-HSA-76002 Platelet activation, signaling and aggregation 8.776153e-01 0.057
R-HSA-1280218 Adaptive Immune System 8.803300e-01 0.055
R-HSA-211945 Phase I - Functionalization of compounds 8.810954e-01 0.055
R-HSA-1483257 Phospholipid metabolism 8.948239e-01 0.048
R-HSA-195721 Signaling by WNT 8.970779e-01 0.047
R-HSA-112315 Transmission across Chemical Synapses 9.140919e-01 0.039
R-HSA-196854 Metabolism of vitamins and cofactors 9.361640e-01 0.029
R-HSA-425407 SLC-mediated transmembrane transport 9.501275e-01 0.022
R-HSA-8978868 Fatty acid metabolism 9.536248e-01 0.021
R-HSA-446203 Asparagine N-linked glycosylation 9.584199e-01 0.018
R-HSA-72766 Translation 9.604861e-01 0.018
R-HSA-392499 Metabolism of proteins 9.666934e-01 0.015
R-HSA-388396 GPCR downstream signalling 9.784492e-01 0.009
R-HSA-9709957 Sensory Perception 9.809102e-01 0.008
R-HSA-372790 Signaling by GPCR 9.873091e-01 0.006
R-HSA-1430728 Metabolism 9.905164e-01 0.004
R-HSA-382551 Transport of small molecules 9.943511e-01 0.002
R-HSA-556833 Metabolism of lipids 9.953289e-01 0.002
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
KISKIS 0.794 0.565 1 0.828
DYRK4DYRK4 0.788 0.629 1 0.870
DYRK2DYRK2 0.786 0.585 1 0.812
JNK2JNK2 0.786 0.671 1 0.870
P38GP38G 0.784 0.639 1 0.885
CDK19CDK19 0.783 0.578 1 0.884
CDK8CDK8 0.782 0.577 1 0.870
CDK17CDK17 0.781 0.614 1 0.876
CDK18CDK18 0.781 0.595 1 0.865
HIPK2HIPK2 0.781 0.553 1 0.851
P38DP38D 0.780 0.633 1 0.891
JNK3JNK3 0.778 0.653 1 0.861
CDK1CDK1 0.778 0.591 1 0.867
P38BP38B 0.778 0.617 1 0.839
DYRK1BDYRK1B 0.775 0.562 1 0.838
ERK1ERK1 0.775 0.593 1 0.847
CDK16CDK16 0.775 0.594 1 0.868
CDK13CDK13 0.775 0.585 1 0.858
CDK7CDK7 0.774 0.563 1 0.855
HIPK1HIPK1 0.772 0.518 1 0.796
CDK3CDK3 0.771 0.526 1 0.876
CDK12CDK12 0.771 0.582 1 0.868
NLKNLK 0.770 0.530 1 0.678
CDK10CDK10 0.770 0.568 1 0.848
HIPK4HIPK4 0.769 0.342 1 0.658
HIPK3HIPK3 0.769 0.510 1 0.765
CDK14CDK14 0.768 0.584 1 0.839
CDK9CDK9 0.768 0.581 1 0.853
P38AP38A 0.768 0.582 1 0.801
CLK3CLK3 0.767 0.365 1 0.654
ERK2ERK2 0.767 0.594 1 0.825
CDK5CDK5 0.766 0.542 1 0.837
DYRK1ADYRK1A 0.764 0.436 1 0.791
DYRK3DYRK3 0.762 0.430 1 0.768
CDK2CDK2 0.761 0.450 1 0.792
SRPK1SRPK1 0.760 0.234 -3 0.542
CLK1CLK1 0.760 0.319 -3 0.517
JNK1JNK1 0.759 0.582 1 0.869
CLK2CLK2 0.758 0.348 -3 0.515
ERK5ERK5 0.757 0.268 1 0.580
CLK4CLK4 0.756 0.295 -3 0.545
SRPK2SRPK2 0.755 0.185 -3 0.467
CDK6CDK6 0.754 0.555 1 0.848
CDK4CDK4 0.754 0.572 1 0.868
PRP4PRP4 0.753 0.358 -3 0.649
MTORMTOR 0.753 0.158 1 0.490
SRPK3SRPK3 0.747 0.169 -3 0.526
COTCOT 0.746 -0.087 2 0.739
CDC7CDC7 0.744 -0.092 1 0.389
PRPKPRPK 0.744 -0.083 -1 0.810
DSTYKDSTYK 0.744 -0.023 2 0.747
CDKL5CDKL5 0.743 0.078 -3 0.587
CDKL1CDKL1 0.743 0.063 -3 0.598
MOSMOS 0.743 -0.027 1 0.404
ICKICK 0.742 0.202 -3 0.622
NUAK2NUAK2 0.742 0.032 -3 0.613
GCN2GCN2 0.741 -0.158 2 0.676
ATRATR 0.740 -0.024 1 0.414
NEK6NEK6 0.739 -0.031 -2 0.767
CAMK1BCAMK1B 0.739 -0.027 -3 0.651
RAF1RAF1 0.739 -0.098 1 0.350
ULK2ULK2 0.739 -0.135 2 0.675
NEK7NEK7 0.738 -0.056 -3 0.751
HUNKHUNK 0.738 -0.025 2 0.731
PDHK4PDHK4 0.737 -0.157 1 0.411
ULK1ULK1 0.737 -0.100 -3 0.699
TBK1TBK1 0.737 -0.169 1 0.300
WNK1WNK1 0.737 -0.043 -2 0.810
BMPR2BMPR2 0.736 -0.157 -2 0.806
IKKEIKKE 0.735 -0.156 1 0.301
IKKBIKKB 0.733 -0.162 -2 0.707
CAMLCKCAMLCK 0.733 -0.009 -2 0.786
PDHK1PDHK1 0.733 -0.165 1 0.383
BMPR1BBMPR1B 0.733 0.023 1 0.369
MLK1MLK1 0.733 -0.123 2 0.702
MARK4MARK4 0.733 -0.016 4 0.887
CAMK2GCAMK2G 0.733 -0.093 2 0.676
RIPK3RIPK3 0.733 -0.097 3 0.669
NIKNIK 0.732 -0.073 -3 0.675
AMPKA1AMPKA1 0.731 -0.045 -3 0.617
RSK2RSK2 0.731 -0.023 -3 0.543
DAPK2DAPK2 0.730 -0.034 -3 0.665
PKN2PKN2 0.730 -0.056 -3 0.629
PRKD1PRKD1 0.730 -0.059 -3 0.579
TSSK2TSSK2 0.730 -0.045 -5 0.753
MST4MST4 0.730 -0.059 2 0.709
TGFBR2TGFBR2 0.730 -0.109 -2 0.724
PIM3PIM3 0.729 -0.085 -3 0.600
ERK7ERK7 0.729 0.172 2 0.446
MOKMOK 0.728 0.323 1 0.696
SKMLCKSKMLCK 0.728 -0.051 -2 0.800
P70S6KBP70S6KB 0.728 -0.019 -3 0.575
PKN3PKN3 0.728 -0.089 -3 0.599
RSK3RSK3 0.727 -0.040 -3 0.536
P90RSKP90RSK 0.727 -0.037 -3 0.551
GRK1GRK1 0.727 -0.039 -2 0.767
GRK5GRK5 0.727 -0.163 -3 0.704
WNK3WNK3 0.727 -0.169 1 0.346
PRKD2PRKD2 0.727 -0.044 -3 0.514
NIM1NIM1 0.726 -0.087 3 0.674
CHAK2CHAK2 0.726 -0.092 -1 0.793
AMPKA2AMPKA2 0.726 -0.041 -3 0.580
MAKMAK 0.725 0.314 -2 0.652
NDR1NDR1 0.725 -0.085 -3 0.595
IRE1IRE1 0.725 -0.097 1 0.322
ATMATM 0.725 -0.046 1 0.379
TGFBR1TGFBR1 0.725 -0.025 -2 0.742
ANKRD3ANKRD3 0.724 -0.135 1 0.375
QIKQIK 0.724 -0.052 -3 0.639
ALK4ALK4 0.724 -0.041 -2 0.762
MAPKAPK3MAPKAPK3 0.724 -0.087 -3 0.538
NEK9NEK9 0.724 -0.136 2 0.701
BRSK1BRSK1 0.724 -0.031 -3 0.554
PINK1PINK1 0.723 0.138 1 0.506
NDR2NDR2 0.723 -0.112 -3 0.588
GRK4GRK4 0.723 -0.127 -2 0.766
TSSK1TSSK1 0.723 -0.057 -3 0.627
GRK6GRK6 0.723 -0.112 1 0.374
MARK3MARK3 0.722 0.027 4 0.870
BRSK2BRSK2 0.722 -0.046 -3 0.586
RIPK1RIPK1 0.722 -0.145 1 0.335
MASTLMASTL 0.722 -0.190 -2 0.764
PRKD3PRKD3 0.722 -0.045 -3 0.514
MLK3MLK3 0.721 -0.090 2 0.646
PKCDPKCD 0.721 -0.073 2 0.678
DNAPKDNAPK 0.721 -0.007 1 0.360
IRE2IRE2 0.721 -0.095 2 0.661
QSKQSK 0.721 -0.020 4 0.891
TTBK2TTBK2 0.720 -0.169 2 0.599
NEK2NEK2 0.720 -0.074 2 0.686
ACVR2BACVR2B 0.720 -0.051 -2 0.729
NUAK1NUAK1 0.720 -0.059 -3 0.549
PAK3PAK3 0.720 -0.073 -2 0.736
SMG1SMG1 0.720 -0.054 1 0.385
MYLK4MYLK4 0.720 -0.009 -2 0.723
PAK6PAK6 0.720 -0.027 -2 0.668
MARK2MARK2 0.720 0.010 4 0.839
MLK2MLK2 0.720 -0.164 2 0.688
DLKDLK 0.719 -0.179 1 0.392
BCKDKBCKDK 0.719 -0.184 -1 0.714
ACVR2AACVR2A 0.719 -0.066 -2 0.721
PIM1PIM1 0.719 -0.041 -3 0.546
SNRKSNRK 0.719 -0.103 2 0.645
PLK1PLK1 0.719 -0.103 -2 0.724
PKACGPKACG 0.718 -0.063 -2 0.672
PHKG1PHKG1 0.718 -0.106 -3 0.591
CAMK2DCAMK2D 0.718 -0.126 -3 0.631
MELKMELK 0.718 -0.097 -3 0.572
AURCAURC 0.718 -0.019 -2 0.609
SIKSIK 0.717 -0.050 -3 0.531
IKKAIKKA 0.717 -0.147 -2 0.690
DRAK1DRAK1 0.717 -0.033 1 0.352
VRK2VRK2 0.717 -0.052 1 0.454
PAK1PAK1 0.717 -0.066 -2 0.730
MSK2MSK2 0.716 -0.064 -3 0.528
CAMK4CAMK4 0.716 -0.127 -3 0.589
YSK4YSK4 0.716 -0.128 1 0.327
CK1ECK1E 0.716 -0.007 -3 0.488
MARK1MARK1 0.716 -0.010 4 0.876
MAPKAPK2MAPKAPK2 0.716 -0.074 -3 0.484
MNK2MNK2 0.716 -0.065 -2 0.738
CAMK1GCAMK1G 0.715 -0.040 -3 0.546
MEK1MEK1 0.715 -0.113 2 0.712
PKRPKR 0.714 -0.115 1 0.355
AKT2AKT2 0.714 -0.006 -3 0.472
SSTKSSTK 0.714 -0.023 4 0.881
BMPR1ABMPR1A 0.713 -0.017 1 0.362
MSK1MSK1 0.713 -0.027 -3 0.533
CHAK1CHAK1 0.713 -0.143 2 0.670
PKCBPKCB 0.713 -0.074 2 0.643
PAK2PAK2 0.713 -0.074 -2 0.719
GRK2GRK2 0.712 -0.062 -2 0.651
LATS2LATS2 0.712 -0.117 -5 0.640
PKG2PKG2 0.712 -0.040 -2 0.609
PIM2PIM2 0.712 -0.007 -3 0.525
ALK2ALK2 0.712 -0.050 -2 0.740
MLK4MLK4 0.712 -0.136 2 0.619
CK1DCK1D 0.712 0.012 -3 0.458
PKCGPKCG 0.712 -0.080 2 0.656
GRK7GRK7 0.712 -0.043 1 0.371
AURBAURB 0.711 -0.027 -2 0.605
SGK3SGK3 0.711 -0.043 -3 0.541
PKCAPKCA 0.711 -0.073 2 0.639
RSK4RSK4 0.711 -0.024 -3 0.500
PKCHPKCH 0.711 -0.089 2 0.645
PLK3PLK3 0.711 -0.095 2 0.675
MAPKAPK5MAPKAPK5 0.710 -0.108 -3 0.530
FAM20CFAM20C 0.710 -0.066 2 0.449
TLK1TLK1 0.710 -0.098 -2 0.761
MNK1MNK1 0.709 -0.065 -2 0.742
CAMK2ACAMK2A 0.709 -0.062 2 0.664
GSK3AGSK3A 0.709 0.111 4 0.368
MST3MST3 0.708 -0.038 2 0.730
TLK2TLK2 0.708 -0.145 1 0.352
HRIHRI 0.708 -0.144 -2 0.769
MEKK3MEKK3 0.708 -0.113 1 0.359
PKACBPKACB 0.708 -0.026 -2 0.618
SMMLCKSMMLCK 0.708 -0.023 -3 0.611
CK1A2CK1A2 0.707 -0.010 -3 0.450
PHKG2PHKG2 0.707 -0.098 -3 0.570
PERKPERK 0.707 -0.149 -2 0.762
PKCZPKCZ 0.707 -0.107 2 0.668
WNK4WNK4 0.707 -0.111 -2 0.792
PLK4PLK4 0.706 -0.145 2 0.597
MEK5MEK5 0.706 -0.149 2 0.707
BRAFBRAF 0.706 -0.090 -4 0.723
MPSK1MPSK1 0.706 -0.014 1 0.359
AURAAURA 0.706 -0.031 -2 0.588
CAMK2BCAMK2B 0.706 -0.104 2 0.628
IRAK4IRAK4 0.706 -0.126 1 0.317
ZAKZAK 0.705 -0.151 1 0.361
LATS1LATS1 0.704 -0.094 -3 0.608
CK1G1CK1G1 0.704 -0.058 -3 0.486
TTBK1TTBK1 0.704 -0.135 2 0.551
MEKK1MEKK1 0.704 -0.176 1 0.363
NEK11NEK11 0.703 -0.071 1 0.362
P70S6KP70S6K 0.703 -0.044 -3 0.503
PKCTPKCT 0.703 -0.083 2 0.645
CHK1CHK1 0.703 -0.115 -3 0.566
NEK5NEK5 0.702 -0.118 1 0.343
GSK3BGSK3B 0.702 0.011 4 0.362
PKCIPKCI 0.702 -0.053 2 0.645
MEKK2MEKK2 0.702 -0.145 2 0.682
GAKGAK 0.702 0.017 1 0.380
AKT1AKT1 0.701 -0.031 -3 0.485
DCAMKL1DCAMKL1 0.701 -0.100 -3 0.531
DCAMKL2DCAMKL2 0.700 -0.090 -3 0.566
PASKPASK 0.700 -0.021 -3 0.632
MEKK6MEKK6 0.700 -0.069 1 0.365
PAK5PAK5 0.699 -0.059 -2 0.617
NEK8NEK8 0.699 -0.120 2 0.716
PKN1PKN1 0.699 -0.062 -3 0.516
LKB1LKB1 0.699 -0.041 -3 0.692
IRAK1IRAK1 0.698 -0.168 -1 0.722
GRK3GRK3 0.698 -0.073 -2 0.614
CK2A2CK2A2 0.698 -0.049 1 0.314
PRKXPRKX 0.698 -0.027 -3 0.441
PKCEPKCE 0.697 -0.033 2 0.647
PAK4PAK4 0.696 -0.053 -2 0.623
TAK1TAK1 0.696 -0.066 1 0.351
TAO2TAO2 0.696 -0.097 2 0.723
PKACAPKACA 0.695 -0.036 -2 0.571
CHK2CHK2 0.695 -0.043 -3 0.418
NEK4NEK4 0.695 -0.089 1 0.312
SBKSBK 0.694 0.043 -3 0.356
TAO3TAO3 0.694 -0.121 1 0.371
CAMKK1CAMKK1 0.694 -0.150 -2 0.692
EEF2KEEF2K 0.693 -0.075 3 0.729
MAP3K15MAP3K15 0.693 -0.110 1 0.356
RIPK2RIPK2 0.692 -0.140 1 0.319
DAPK3DAPK3 0.692 -0.047 -3 0.568
CK2A1CK2A1 0.692 -0.046 1 0.306
CAMK1DCAMK1D 0.692 -0.074 -3 0.445
STK33STK33 0.692 -0.091 2 0.560
PDK1PDK1 0.692 -0.109 1 0.364
SGK1SGK1 0.691 -0.008 -3 0.401
CAMKK2CAMKK2 0.691 -0.129 -2 0.693
HPK1HPK1 0.690 -0.056 1 0.335
AKT3AKT3 0.690 -0.022 -3 0.411
DAPK1DAPK1 0.690 -0.037 -3 0.563
BUB1BUB1 0.690 -0.024 -5 0.708
LRRK2LRRK2 0.690 -0.065 2 0.728
MRCKBMRCKB 0.689 -0.023 -3 0.515
GCKGCK 0.689 -0.087 1 0.348
HGKHGK 0.689 -0.106 3 0.778
LOKLOK 0.688 -0.095 -2 0.735
MST2MST2 0.688 -0.136 1 0.343
NEK3NEK3 0.688 -0.074 1 0.344
CAMK1ACAMK1A 0.687 -0.057 -3 0.423
NEK1NEK1 0.687 -0.096 1 0.315
MINKMINK 0.686 -0.131 1 0.321
MRCKAMRCKA 0.686 -0.030 -3 0.525
TNIKTNIK 0.686 -0.094 3 0.771
VRK1VRK1 0.684 -0.167 2 0.741
PBKPBK 0.684 -0.055 1 0.332
MST1MST1 0.682 -0.130 1 0.323
PKG1PKG1 0.682 -0.059 -2 0.548
PDHK3_TYRPDHK3_TYR 0.681 0.080 4 0.826
DMPK1DMPK1 0.681 0.008 -3 0.526
YSK1YSK1 0.681 -0.126 2 0.682
ROCK2ROCK2 0.681 -0.043 -3 0.555
MEK2MEK2 0.680 -0.169 2 0.684
PLK2PLK2 0.680 -0.093 -3 0.615
SLKSLK 0.679 -0.096 -2 0.689
CRIKCRIK 0.678 0.005 -3 0.475
KHS2KHS2 0.678 -0.066 1 0.339
KHS1KHS1 0.678 -0.103 1 0.323
TESK1_TYRTESK1_TYR 0.677 0.004 3 0.794
HASPINHASPIN 0.677 -0.041 -1 0.595
PKMYT1_TYRPKMYT1_TYR 0.676 0.048 3 0.760
BIKEBIKE 0.676 -0.035 1 0.320
EPHA6EPHA6 0.675 0.007 -1 0.848
BMPR2_TYRBMPR2_TYR 0.675 0.050 -1 0.822
ROCK1ROCK1 0.674 -0.034 -3 0.525
MAP2K7_TYRMAP2K7_TYR 0.673 -0.065 2 0.747
CK1ACK1A 0.673 -0.041 -3 0.387
MAP2K6_TYRMAP2K6_TYR 0.673 0.036 -1 0.818
PDHK4_TYRPDHK4_TYR 0.673 0.047 2 0.759
MAP2K4_TYRMAP2K4_TYR 0.672 -0.024 -1 0.811
LIMK2_TYRLIMK2_TYR 0.672 0.034 -3 0.696
PDHK1_TYRPDHK1_TYR 0.672 -0.008 -1 0.839
ASK1ASK1 0.672 -0.123 1 0.352
ALPHAK3ALPHAK3 0.671 -0.071 -1 0.767
TTKTTK 0.670 -0.121 -2 0.739
OSR1OSR1 0.670 -0.132 2 0.664
PINK1_TYRPINK1_TYR 0.670 -0.113 1 0.401
YANK3YANK3 0.668 -0.065 2 0.360
RETRET 0.667 -0.109 1 0.370
MYO3BMYO3B 0.667 -0.099 2 0.693
TXKTXK 0.667 -0.012 1 0.380
TAO1TAO1 0.667 -0.123 1 0.322
EPHB4EPHB4 0.667 -0.060 -1 0.806
MST1RMST1R 0.667 -0.082 3 0.726
LIMK1_TYRLIMK1_TYR 0.665 -0.064 2 0.727
FGFR2FGFR2 0.665 -0.016 3 0.725
JAK3JAK3 0.664 -0.078 1 0.379
MYO3AMYO3A 0.663 -0.124 1 0.321
JAK2JAK2 0.663 -0.133 1 0.380
AAK1AAK1 0.663 -0.014 1 0.287
CSF1RCSF1R 0.663 -0.086 3 0.708
TYRO3TYRO3 0.663 -0.134 3 0.707
FGFR1FGFR1 0.661 -0.038 3 0.687
TEKTEK 0.661 0.008 3 0.636
ABL1ABL1 0.661 -0.070 -1 0.814
DDR1DDR1 0.661 -0.076 4 0.782
ABL2ABL2 0.661 -0.079 -1 0.813
EPHA4EPHA4 0.661 -0.024 2 0.692
ITKITK 0.660 -0.047 -1 0.802
ROS1ROS1 0.660 -0.157 3 0.678
FGRFGR 0.659 -0.118 1 0.354
TYK2TYK2 0.659 -0.211 1 0.353
EPHB1EPHB1 0.659 -0.084 1 0.375
SRMSSRMS 0.659 -0.073 1 0.366
KDRKDR 0.658 -0.062 3 0.688
KITKIT 0.658 -0.076 3 0.705
FERFER 0.658 -0.141 1 0.385
HCKHCK 0.657 -0.102 -1 0.834
NEK10_TYRNEK10_TYR 0.657 -0.096 1 0.314
TNNI3K_TYRTNNI3K_TYR 0.657 -0.047 1 0.390
EPHB2EPHB2 0.657 -0.074 -1 0.798
YES1YES1 0.656 -0.094 -1 0.829
LCKLCK 0.656 -0.071 -1 0.844
STLK3STLK3 0.656 -0.186 1 0.331
FGFR3FGFR3 0.656 -0.025 3 0.700
BLKBLK 0.655 -0.045 -1 0.841
EPHB3EPHB3 0.655 -0.096 -1 0.803
FLT3FLT3 0.655 -0.127 3 0.705
PTK2BPTK2B 0.655 -0.016 -1 0.786
JAK1JAK1 0.655 -0.107 1 0.337
TECTEC 0.655 -0.061 -1 0.749
INSRRINSRR 0.654 -0.123 3 0.666
BMXBMX 0.654 -0.045 -1 0.730
FLT1FLT1 0.654 -0.060 -1 0.814
MERTKMERTK 0.653 -0.112 3 0.700
TNK2TNK2 0.653 -0.106 3 0.663
PDGFRBPDGFRB 0.653 -0.181 3 0.711
METMET 0.653 -0.083 3 0.705
AXLAXL 0.652 -0.132 3 0.700
FRKFRK 0.651 -0.082 -1 0.837
WEE1_TYRWEE1_TYR 0.651 -0.067 -1 0.718
CK1G3CK1G3 0.651 -0.054 -3 0.352
EPHA7EPHA7 0.650 -0.076 2 0.688
BTKBTK 0.650 -0.135 -1 0.766
ERBB2ERBB2 0.649 -0.107 1 0.348
FYNFYN 0.649 -0.042 -1 0.821
EPHA1EPHA1 0.649 -0.106 3 0.693
TNK1TNK1 0.648 -0.125 3 0.688
FLT4FLT4 0.648 -0.101 3 0.673
PDGFRAPDGFRA 0.647 -0.199 3 0.696
EPHA3EPHA3 0.646 -0.093 2 0.672
PTK2PTK2 0.646 0.009 -1 0.785
ALKALK 0.646 -0.152 3 0.626
LYNLYN 0.645 -0.093 3 0.614
LTKLTK 0.645 -0.146 3 0.655
EGFREGFR 0.645 -0.082 1 0.320
MATKMATK 0.644 -0.077 -1 0.748
EPHA8EPHA8 0.643 -0.078 -1 0.810
DDR2DDR2 0.642 -0.045 3 0.658
SYKSYK 0.642 -0.019 -1 0.781
EPHA5EPHA5 0.642 -0.084 2 0.685
PTK6PTK6 0.642 -0.193 -1 0.752
INSRINSR 0.642 -0.150 3 0.640
SRCSRC 0.640 -0.082 -1 0.825
NTRK2NTRK2 0.640 -0.196 3 0.662
MUSKMUSK 0.640 -0.108 1 0.285
NTRK1NTRK1 0.640 -0.201 -1 0.774
FGFR4FGFR4 0.638 -0.088 -1 0.771
EPHA2EPHA2 0.637 -0.068 -1 0.774
ERBB4ERBB4 0.637 -0.047 1 0.327
NTRK3NTRK3 0.637 -0.159 -1 0.736
YANK2YANK2 0.637 -0.080 2 0.360
CK1G2CK1G2 0.637 -0.039 -3 0.422
CSKCSK 0.635 -0.129 2 0.684
ZAP70ZAP70 0.630 -0.016 -1 0.706
FESFES 0.627 -0.093 -1 0.727
IGF1RIGF1R 0.626 -0.141 3 0.576