Motif 359 (n=90)

Position-wise Probabilities

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uniprot genes site source protein function
A1L390 PLEKHG3 S1079 ochoa Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.
A4D1P6 WDR91 S272 ochoa WD repeat-containing protein 91 Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}.
A6NKT7 RGPD3 S393 ochoa RanBP2-like and GRIP domain-containing protein 3 None
H0YIS7 RNASEK-C17orf49 S160 ochoa BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}.
O14497 ARID1A Y762 ochoa AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
O14686 KMT2D S2309 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14686 KMT2D S4617 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O15047 SETD1A S532 ochoa Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}.
O43561 LAT S131 ochoa Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}.
O60245 PCDH7 S998 ochoa Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) None
O60296 TRAK2 Y755 ochoa Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}.
O60307 MAST3 S1180 ochoa Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) None
O60673 REV3L S2171 ochoa DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}.
O75420 GIGYF1 S366 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75420 GIGYF1 S368 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75427 LRCH4 S279 ochoa Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}.
O75665 OFD1 S762 ochoa Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.
O94868 FCHSD2 S644 ochoa F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.
P03372 ESR1 S104 psp Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}.
P23497 SP100 S189 ochoa Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.
P26651 ZFP36 S188 ochoa mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}.
P31150 GDI1 S222 ochoa Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4) Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}.
P36873 PPP1CC S48 ochoa Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}.
P42694 HELZ S1247 ochoa Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
P49792 RANBP2 S392 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49815 TSC2 S1252 ochoa Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P50395 GDI2 S222 ochoa Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}.
P62136 PPP1CA S48 ochoa Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}.
P62140 PPP1CB S47 ochoa Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}.
P78524 DENND2B S30 ochoa DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
P98174 FGD1 S114 ochoa FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}.
Q02410 APBA1 S246 ochoa Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}.
Q08174 PCDH1 S971 ochoa Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) May be involved in cell-cell interaction processes and in cell adhesion.
Q13470 TNK1 S500 ochoa Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.
Q14676 MDC1 S964 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q15365 PCBP1 S171 ochoa Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.
Q15366 PCBP2 S171 ochoa Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}.
Q15648 MED1 Y1431 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15758 SLC1A5 S491 ochoa Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}.
Q5D1E8 ZC3H12A S99 ochoa Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:22561375, PubMed:26134560, PubMed:26320658). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q5D1E7, ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18364357, ECO:0000269|PubMed:19185603, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:22561375, ECO:0000269|PubMed:24048733, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:26134560, ECO:0000269|PubMed:26320658}.; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. {ECO:0000269|PubMed:23355615}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. {ECO:0000269|PubMed:24191027}.
Q5SXM2 SNAPC4 S1161 ochoa snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
Q5SYE7 NHSL1 S725 ochoa NHS-like protein 1 None
Q5SYE7 NHSL1 S1274 ochoa NHS-like protein 1 None
Q5T3I0 GPATCH4 S89 ochoa G patch domain-containing protein 4 None
Q5T5P2 KIAA1217 S1877 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5VT52 RPRD2 S436 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q63ZY3 KANK2 S155 ochoa KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}.
Q6IAA8 LAMTOR1 S96 ochoa Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}.
Q6NUJ5 PWWP2B S456 ochoa PWWP domain-containing protein 2B Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}.
Q7Z3J3 RGPD4 S393 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q8IXM2 BACC1 S119 ochoa BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) Component of chromatin complexes such as the MLL1/MLL and NURF complexes.
Q8IZD0 SAMD14 S54 ochoa Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) None
Q8N163 CCAR2 S611 ochoa Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}.
Q8N1G0 ZNF687 S251 ochoa Zinc finger protein 687 May be involved in transcriptional regulation.
Q8N4C8 MINK1 S916 ochoa Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8NC74 RBBP8NL S464 ochoa RBBP8 N-terminal-like protein None
Q8WXE0 CASKIN2 S368 ochoa Caskin-2 (CASK-interacting protein 2) None
Q8WXI9 GATAD2B S495 ochoa Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}.
Q92793 CREBBP S90 ochoa CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}.
Q92934 BAD S32 ochoa Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
Q96A00 PPP1R14A S128 ochoa Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17) Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Q96BH1 RNF25 S295 ochoa E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951216). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (PubMed:36638793). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (PubMed:36638793, PubMed:37651229). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (PubMed:12748188). {ECO:0000250|UniProtKB:Q9QZR0, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951216}.
Q96EV2 RBM33 S849 ochoa RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}.
Q96HC4 PDLIM5 S360 ochoa PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}.
Q96KV7 WDR90 S239 ochoa WD repeat-containing protein 90 Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability (PubMed:32946374). Required for efficient primary cilium formation (PubMed:28781053). {ECO:0000269|PubMed:28781053}.
Q9BV36 MLPH S264 ochoa Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.
Q9BV36 MLPH S266 ochoa Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.
Q9BVG8 KIFC3 S781 ochoa Kinesin-like protein KIFC3 Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269|PubMed:19041755}.
Q9C0C2 TNKS1BP1 S1138 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0K0 BCL11B S256 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9H2P0 ADNP S424 ochoa Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}.
Q9H9E1 ANKRA2 S104 ochoa Ankyrin repeat family A protein 2 (RFXANK-like protein 2) May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000269|PubMed:25752541}.
Q9HCD5 NCOA5 S448 ochoa Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.
Q9NQS1 AVEN S261 ochoa Cell death regulator Aven Protects against apoptosis mediated by Apaf-1.
Q9NUQ6 SPATS2L Y361 ochoa SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) None
Q9NZ53 PODXL2 S558 ochoa Podocalyxin-like protein 2 (Endoglycan) Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}.
Q9NZQ3 NCKIPSD Y161 psp NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.
Q9P2F8 SIPA1L2 S1520 ochoa Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) None
Q9UBF8 PI4KB S256 ochoa Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}.
Q9UBP9 GULP1 S211 ochoa PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}.
Q9UHK6 AMACR S324 ochoa Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:10655068, PubMed:11060359, PubMed:7649182). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:10655068, PubMed:11060359, PubMed:7649182). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}.
Q9UI36 DACH1 S491 psp Dachshund homolog 1 (Dach1) Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269|PubMed:14525983}.
Q9ULD2 MTUS1 S181 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9UMS6 SYNPO2 S224 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9Y4F1 FARP1 S861 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y4H2 IRS2 S770 ochoa Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
P11586 MTHFD1 S870 Sugiyama C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}.
Q5T1R4 HIVEP3 S1678 Sugiyama Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}.
P36894 BMPR1A S213 Sugiyama Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}.
P08151 GLI1 Y925 GPS6 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
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reactome_id name p -log10_p
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.000139 3.857
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.000168 3.775
R-HSA-1257604 PIP3 activates AKT signaling 0.000708 3.150
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.000707 3.151
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.001136 2.944
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.001762 2.754
R-HSA-9660537 Signaling by MRAS-complex mutants 0.002123 2.673
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.002123 2.673
R-HSA-9909396 Circadian clock 0.002195 2.659
R-HSA-9006925 Intracellular signaling by second messengers 0.001707 2.768
R-HSA-163560 Triglyceride catabolism 0.002397 2.620
R-HSA-9828806 Maturation of hRSV A proteins 0.001132 2.946
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.001621 2.790
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.002603 2.585
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 0.002896 2.538
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.003882 2.411
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.003861 2.413
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.004075 2.390
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.004404 2.356
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.006138 2.212
R-HSA-4839726 Chromatin organization 0.006191 2.208
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.007439 2.128
R-HSA-162582 Signal Transduction 0.007210 2.142
R-HSA-9007101 Rab regulation of trafficking 0.008634 2.064
R-HSA-8979227 Triglyceride metabolism 0.008165 2.088
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.010049 1.998
R-HSA-3700989 Transcriptional Regulation by TP53 0.009788 2.009
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.010378 1.984
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.012158 1.915
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.013748 1.862
R-HSA-9932451 SWI/SNF chromatin remodelers 0.015586 1.807
R-HSA-9932444 ATP-dependent chromatin remodelers 0.015586 1.807
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.015902 1.799
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.020060 1.698
R-HSA-8939211 ESR-mediated signaling 0.020738 1.683
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.021289 1.672
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.020613 1.686
R-HSA-212165 Epigenetic regulation of gene expression 0.018660 1.729
R-HSA-8878171 Transcriptional regulation by RUNX1 0.017545 1.756
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.020613 1.686
R-HSA-3247509 Chromatin modifying enzymes 0.019832 1.703
R-HSA-9006936 Signaling by TGFB family members 0.023763 1.624
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.026219 1.581
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.027407 1.562
R-HSA-5673000 RAF activation 0.026219 1.581
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.026219 1.581
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.029975 1.523
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.029975 1.523
R-HSA-9009391 Extra-nuclear estrogen signaling 0.031402 1.503
R-HSA-5610787 Hedgehog 'off' state 0.030700 1.513
R-HSA-73857 RNA Polymerase II Transcription 0.029543 1.530
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.028644 1.543
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.032367 1.490
R-HSA-3214841 PKMTs methylate histone lysines 0.034970 1.456
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.035863 1.445
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.035863 1.445
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.041715 1.380
R-HSA-74713 IRS activation 0.041715 1.380
R-HSA-9027283 Erythropoietin activates STAT5 0.053314 1.273
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.059061 1.229
R-HSA-112412 SOS-mediated signalling 0.059061 1.229
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.070452 1.152
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 0.076096 1.119
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.087283 1.059
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 0.092827 1.032
R-HSA-9027284 Erythropoietin activates RAS 0.109257 0.962
R-HSA-111447 Activation of BAD and translocation to mitochondria 0.109257 0.962
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.109257 0.962
R-HSA-5656121 Translesion synthesis by POLI 0.114668 0.941
R-HSA-5655862 Translesion synthesis by POLK 0.120046 0.921
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.037651 1.424
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.156800 0.805
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.064959 1.187
R-HSA-9006335 Signaling by Erythropoietin 0.192034 0.717
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.196947 0.706
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.201831 0.695
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.201831 0.695
R-HSA-1855170 IPs transport between nucleus and cytosol 0.211510 0.675
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.211510 0.675
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.216305 0.665
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.225810 0.646
R-HSA-383280 Nuclear Receptor transcription pathway 0.096978 1.013
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.244480 0.612
R-HSA-141424 Amplification of signal from the kinetochores 0.112385 0.949
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.112385 0.949
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.249077 0.604
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.098336 1.007
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.114354 0.942
R-HSA-9018519 Estrogen-dependent gene expression 0.067205 1.173
R-HSA-198203 PI3K/AKT activation 0.076096 1.119
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.177116 0.752
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.054412 1.264
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.054412 1.264
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.120046 0.921
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.054412 1.264
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.092827 1.032
R-HSA-2424491 DAP12 signaling 0.196947 0.706
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.103813 0.984
R-HSA-110312 Translesion synthesis by REV1 0.109257 0.962
R-HSA-202433 Generation of second messenger molecules 0.249077 0.604
R-HSA-165159 MTOR signalling 0.037651 1.424
R-HSA-5619507 Activation of HOX genes during differentiation 0.157505 0.803
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.157505 0.803
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.087283 1.059
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.216305 0.665
R-HSA-69618 Mitotic Spindle Checkpoint 0.146955 0.833
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.138629 0.858
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.053314 1.273
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.087283 1.059
R-HSA-350054 Notch-HLH transcription pathway 0.156800 0.805
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.085863 1.066
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.216305 0.665
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.235201 0.629
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.249077 0.604
R-HSA-201451 Signaling by BMP 0.182119 0.740
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.198713 0.702
R-HSA-9843745 Adipogenesis 0.061142 1.214
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.092827 1.032
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.064774 1.189
R-HSA-74749 Signal attenuation 0.076096 1.119
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.108475 0.965
R-HSA-9006931 Signaling by Nuclear Receptors 0.084988 1.071
R-HSA-9764302 Regulation of CDH19 Expression and Function 0.047532 1.323
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.064774 1.189
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.156800 0.805
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.216305 0.665
R-HSA-68877 Mitotic Prometaphase 0.139550 0.855
R-HSA-5632684 Hedgehog 'on' state 0.084051 1.075
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.078688 1.104
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.249077 0.604
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.249077 0.604
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.166045 0.780
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.196947 0.706
R-HSA-933541 TRAF6 mediated IRF7 activation 0.235201 0.629
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.053314 1.273
R-HSA-193648 NRAGE signals death through JNK 0.058435 1.233
R-HSA-180746 Nuclear import of Rev protein 0.221072 0.655
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.151157 0.821
R-HSA-5358351 Signaling by Hedgehog 0.069285 1.159
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.120046 0.921
R-HSA-8943724 Regulation of PTEN gene transcription 0.064959 1.187
R-HSA-114452 Activation of BH3-only proteins 0.196947 0.706
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.070452 1.152
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.114668 0.941
R-HSA-166208 mTORC1-mediated signalling 0.156800 0.805
R-HSA-429947 Deadenylation of mRNA 0.167019 0.777
R-HSA-177243 Interactions of Rev with host cellular proteins 0.249077 0.604
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.249077 0.604
R-HSA-74158 RNA Polymerase III Transcription 0.230520 0.637
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.061667 1.210
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.230520 0.637
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.041815 1.379
R-HSA-1251985 Nuclear signaling by ERBB4 0.249077 0.604
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.041715 1.380
R-HSA-111458 Formation of apoptosome 0.076096 1.119
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.130706 0.884
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.211510 0.675
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.239854 0.620
R-HSA-3371568 Attenuation phase 0.249077 0.604
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.168193 0.774
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.182119 0.740
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.167019 0.777
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.177116 0.752
R-HSA-9842860 Regulation of endogenous retroelements 0.151157 0.821
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.066627 1.176
R-HSA-3371556 Cellular response to heat stress 0.049838 1.302
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.134506 0.871
R-HSA-9627069 Regulation of the apoptosome activity 0.076096 1.119
R-HSA-111461 Cytochrome c-mediated apoptotic response 0.087283 1.059
R-HSA-9675151 Disorders of Developmental Biology 0.120046 0.921
R-HSA-9833109 Evasion by RSV of host interferon responses 0.201831 0.695
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.244480 0.612
R-HSA-196757 Metabolism of folate and pterines 0.235201 0.629
R-HSA-6794361 Neurexins and neuroligins 0.052158 1.283
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.201831 0.695
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.183356 0.737
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.076096 1.119
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.058435 1.233
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.196947 0.706
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.203130 0.692
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.059061 1.229
R-HSA-9819196 Zygotic genome activation (ZGA) 0.146457 0.834
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.087687 1.057
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.146457 0.834
R-HSA-9833110 RSV-host interactions 0.157505 0.803
R-HSA-74160 Gene expression (Transcription) 0.054697 1.262
R-HSA-2586552 Signaling by Leptin 0.076096 1.119
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.221072 0.655
R-HSA-69620 Cell Cycle Checkpoints 0.239911 0.620
R-HSA-5662702 Melanin biosynthesis 0.141238 0.850
R-HSA-389887 Beta-oxidation of pristanoyl-CoA 0.172083 0.764
R-HSA-6794362 Protein-protein interactions at synapses 0.110426 0.957
R-HSA-180024 DARPP-32 events 0.192034 0.717
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.182119 0.740
R-HSA-212436 Generic Transcription Pathway 0.053435 1.272
R-HSA-111471 Apoptotic factor-mediated response 0.130706 0.884
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.156800 0.805
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.070005 1.155
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.211510 0.675
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 0.225810 0.646
R-HSA-5689896 Ovarian tumor domain proteases 0.235201 0.629
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.235201 0.629
R-HSA-6807070 PTEN Regulation 0.245536 0.610
R-HSA-8878166 Transcriptional regulation by RUNX2 0.194308 0.712
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.211510 0.675
R-HSA-9730414 MITF-M-regulated melanocyte development 0.169826 0.770
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.098869 1.005
R-HSA-2559580 Oxidative Stress Induced Senescence 0.151157 0.821
R-HSA-9707564 Cytoprotection by HMOX1 0.106534 0.973
R-HSA-6802957 Oncogenic MAPK signaling 0.110426 0.957
R-HSA-8853659 RET signaling 0.230520 0.637
R-HSA-9707616 Heme signaling 0.068309 1.166
R-HSA-114604 GPVI-mediated activation cascade 0.230520 0.637
R-HSA-193704 p75 NTR receptor-mediated signalling 0.144864 0.839
R-HSA-1266695 Interleukin-7 signaling 0.172083 0.764
R-HSA-982772 Growth hormone receptor signaling 0.161925 0.791
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.102681 0.989
R-HSA-9768919 NPAS4 regulates expression of target genes 0.221072 0.655
R-HSA-1592230 Mitochondrial biogenesis 0.189916 0.721
R-HSA-5673001 RAF/MAP kinase cascade 0.120139 0.920
R-HSA-5684996 MAPK1/MAPK3 signaling 0.127414 0.895
R-HSA-5683057 MAPK family signaling cascades 0.185495 0.732
R-HSA-1632852 Macroautophagy 0.250030 0.602
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.253646 0.596
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.253646 0.596
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.253646 0.596
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.253646 0.596
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.254527 0.594
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.258188 0.588
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.258188 0.588
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.262703 0.581
R-HSA-110329 Cleavage of the damaged pyrimidine 0.262703 0.581
R-HSA-73928 Depyrimidination 0.262703 0.581
R-HSA-8854214 TBC/RABGAPs 0.267190 0.573
R-HSA-2172127 DAP12 interactions 0.271651 0.566
R-HSA-3214858 RMTs methylate histone arginines 0.271651 0.566
R-HSA-9856651 MITF-M-dependent gene expression 0.272528 0.565
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.274185 0.562
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.276084 0.559
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.280491 0.552
R-HSA-73887 Death Receptor Signaling 0.281527 0.550
R-HSA-1989781 PPARA activates gene expression 0.283775 0.547
R-HSA-9612973 Autophagy 0.286024 0.544
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.288271 0.540
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.289225 0.539
R-HSA-877300 Interferon gamma signaling 0.292764 0.533
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.293553 0.532
R-HSA-73893 DNA Damage Bypass 0.293553 0.532
R-HSA-109704 PI3K Cascade 0.297855 0.526
R-HSA-2262752 Cellular responses to stress 0.298222 0.525
R-HSA-109581 Apoptosis 0.299497 0.524
R-HSA-3371571 HSF1-dependent transactivation 0.302130 0.520
R-HSA-156584 Cytosolic sulfonation of small molecules 0.302130 0.520
R-HSA-2467813 Separation of Sister Chromatids 0.303981 0.517
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.306380 0.514
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.306380 0.514
R-HSA-9639288 Amino acids regulate mTORC1 0.310604 0.508
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.314803 0.502
R-HSA-3214815 HDACs deacetylate histones 0.318977 0.496
R-HSA-9012852 Signaling by NOTCH3 0.318977 0.496
R-HSA-112399 IRS-mediated signalling 0.327248 0.485
R-HSA-2980766 Nuclear Envelope Breakdown 0.327248 0.485
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.327248 0.485
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.335420 0.474
R-HSA-191859 snRNP Assembly 0.335420 0.474
R-HSA-194441 Metabolism of non-coding RNA 0.335420 0.474
R-HSA-9033241 Peroxisomal protein import 0.335420 0.474
R-HSA-429914 Deadenylation-dependent mRNA decay 0.335420 0.474
R-HSA-352230 Amino acid transport across the plasma membrane 0.335420 0.474
R-HSA-186712 Regulation of beta-cell development 0.335420 0.474
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.339470 0.469
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.339470 0.469
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.339470 0.469
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.339470 0.469
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.339470 0.469
R-HSA-2559583 Cellular Senescence 0.341844 0.466
R-HSA-1852241 Organelle biogenesis and maintenance 0.342232 0.466
R-HSA-2428928 IRS-related events triggered by IGF1R 0.343494 0.464
R-HSA-168325 Viral Messenger RNA Synthesis 0.343494 0.464
R-HSA-9793380 Formation of paraxial mesoderm 0.343494 0.464
R-HSA-6784531 tRNA processing in the nucleus 0.347495 0.459
R-HSA-201681 TCF dependent signaling in response to WNT 0.348467 0.458
R-HSA-8957322 Metabolism of steroids 0.348884 0.457
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.351471 0.454
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.351471 0.454
R-HSA-69275 G2/M Transition 0.355068 0.450
R-HSA-74751 Insulin receptor signalling cascade 0.355423 0.449
R-HSA-2428924 IGF1R signaling cascade 0.355423 0.449
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.359352 0.444
R-HSA-1234174 Cellular response to hypoxia 0.359352 0.444
R-HSA-453274 Mitotic G2-G2/M phases 0.359456 0.444
R-HSA-8854518 AURKA Activation by TPX2 0.363257 0.440
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.363257 0.440
R-HSA-5693606 DNA Double Strand Break Response 0.367138 0.435
R-HSA-9958863 SLC-mediated transport of amino acids 0.367138 0.435
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.367138 0.435
R-HSA-72163 mRNA Splicing - Major Pathway 0.372556 0.429
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.376899 0.424
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.378642 0.422
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.378642 0.422
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.378642 0.422
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.382430 0.417
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.382430 0.417
R-HSA-5578749 Transcriptional regulation by small RNAs 0.386196 0.413
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.386196 0.413
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.389939 0.409
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.389939 0.409
R-HSA-69473 G2/M DNA damage checkpoint 0.393659 0.405
R-HSA-1236394 Signaling by ERBB4 0.393659 0.405
R-HSA-9013694 Signaling by NOTCH4 0.393659 0.405
R-HSA-72172 mRNA Splicing 0.396291 0.402
R-HSA-380287 Centrosome maturation 0.397357 0.401
R-HSA-1169408 ISG15 antiviral mechanism 0.397357 0.401
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.397357 0.401
R-HSA-5357801 Programmed Cell Death 0.398429 0.400
R-HSA-9824446 Viral Infection Pathways 0.399135 0.399
R-HSA-1980143 Signaling by NOTCH1 0.401032 0.397
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.401032 0.397
R-HSA-73894 DNA Repair 0.408286 0.389
R-HSA-73864 RNA Polymerase I Transcription 0.408316 0.389
R-HSA-416482 G alpha (12/13) signalling events 0.408316 0.389
R-HSA-8953897 Cellular responses to stimuli 0.416076 0.381
R-HSA-5693607 Processing of DNA double-strand break ends 0.419079 0.378
R-HSA-68882 Mitotic Anaphase 0.421716 0.375
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.422623 0.374
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.423811 0.373
R-HSA-418990 Adherens junctions interactions 0.425902 0.371
R-HSA-390918 Peroxisomal lipid metabolism 0.429648 0.367
R-HSA-390466 Chaperonin-mediated protein folding 0.443444 0.353
R-HSA-68886 M Phase 0.445450 0.351
R-HSA-9705683 SARS-CoV-2-host interactions 0.446595 0.350
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.446841 0.350
R-HSA-913531 Interferon Signaling 0.447046 0.350
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.453574 0.343
R-HSA-112310 Neurotransmitter release cycle 0.453574 0.343
R-HSA-73884 Base Excision Repair 0.453574 0.343
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.456910 0.340
R-HSA-1640170 Cell Cycle 0.457737 0.339
R-HSA-74752 Signaling by Insulin receptor 0.463521 0.334
R-HSA-391251 Protein folding 0.463521 0.334
R-HSA-9679506 SARS-CoV Infections 0.466520 0.331
R-HSA-69278 Cell Cycle, Mitotic 0.481167 0.318
R-HSA-8878159 Transcriptional regulation by RUNX3 0.482881 0.316
R-HSA-9614085 FOXO-mediated transcription 0.489180 0.311
R-HSA-3214847 HATs acetylate histones 0.489180 0.311
R-HSA-192105 Synthesis of bile acids and bile salts 0.489180 0.311
R-HSA-70171 Glycolysis 0.492300 0.308
R-HSA-421270 Cell-cell junction organization 0.492579 0.308
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.498485 0.302
R-HSA-1483255 PI Metabolism 0.498485 0.302
R-HSA-111885 Opioid Signalling 0.504595 0.297
R-HSA-9692914 SARS-CoV-1-host interactions 0.513623 0.289
R-HSA-9734767 Developmental Cell Lineages 0.515615 0.288
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.516596 0.287
R-HSA-9700206 Signaling by ALK in cancer 0.516596 0.287
R-HSA-211000 Gene Silencing by RNA 0.516596 0.287
R-HSA-9711123 Cellular response to chemical stress 0.525011 0.280
R-HSA-202403 TCR signaling 0.525407 0.280
R-HSA-194068 Bile acid and bile salt metabolism 0.525407 0.280
R-HSA-2871796 FCERI mediated MAPK activation 0.531192 0.275
R-HSA-1483249 Inositol phosphate metabolism 0.531192 0.275
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.534059 0.272
R-HSA-76002 Platelet activation, signaling and aggregation 0.536126 0.271
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.536908 0.270
R-HSA-446728 Cell junction organization 0.543438 0.265
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.545352 0.263
R-HSA-70326 Glucose metabolism 0.550897 0.259
R-HSA-5693538 Homology Directed Repair 0.553644 0.257
R-HSA-68875 Mitotic Prophase 0.559089 0.253
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.561787 0.250
R-HSA-162909 Host Interactions of HIV factors 0.569782 0.244
R-HSA-195721 Signaling by WNT 0.578803 0.237
R-HSA-114608 Platelet degranulation 0.580218 0.236
R-HSA-69481 G2/M Checkpoints 0.580218 0.236
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.582788 0.234
R-HSA-199991 Membrane Trafficking 0.584724 0.233
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.597882 0.223
R-HSA-8953854 Metabolism of RNA 0.601017 0.221
R-HSA-1500931 Cell-Cell communication 0.608909 0.215
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.617169 0.210
R-HSA-9664417 Leishmania phagocytosis 0.617169 0.210
R-HSA-9664407 Parasite infection 0.617169 0.210
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.619515 0.208
R-HSA-162599 Late Phase of HIV Life Cycle 0.624164 0.205
R-HSA-166520 Signaling by NTRKs 0.637775 0.195
R-HSA-9758941 Gastrulation 0.639996 0.194
R-HSA-9679191 Potential therapeutics for SARS 0.642203 0.192
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.644397 0.191
R-HSA-5693532 DNA Double-Strand Break Repair 0.648744 0.188
R-HSA-9609507 Protein localization 0.648744 0.188
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.650898 0.186
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.653039 0.185
R-HSA-9610379 HCMV Late Events 0.657282 0.182
R-HSA-162587 HIV Life Cycle 0.657282 0.182
R-HSA-9711097 Cellular response to starvation 0.659385 0.181
R-HSA-9694516 SARS-CoV-2 Infection 0.659854 0.181
R-HSA-5633007 Regulation of TP53 Activity 0.663551 0.178
R-HSA-5619102 SLC transporter disorders 0.677739 0.169
R-HSA-1643685 Disease 0.681584 0.166
R-HSA-72306 tRNA processing 0.685579 0.164
R-HSA-5621481 C-type lectin receptors (CLRs) 0.687510 0.163
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.689428 0.162
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.691335 0.160
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.691335 0.160
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.693231 0.159
R-HSA-9678108 SARS-CoV-1 Infection 0.695115 0.158
R-HSA-168255 Influenza Infection 0.702536 0.153
R-HSA-5617833 Cilium Assembly 0.722036 0.141
R-HSA-5663205 Infectious disease 0.726363 0.139
R-HSA-9609690 HCMV Early Events 0.732133 0.135
R-HSA-389948 Co-inhibition by PD-1 0.738662 0.132
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.743455 0.129
R-HSA-5653656 Vesicle-mediated transport 0.748688 0.126
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.758812 0.120
R-HSA-1266738 Developmental Biology 0.772625 0.112
R-HSA-162906 HIV Infection 0.780158 0.108
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.784197 0.106
R-HSA-6798695 Neutrophil degranulation 0.791387 0.102
R-HSA-156580 Phase II - Conjugation of compounds 0.795879 0.099
R-HSA-157118 Signaling by NOTCH 0.797138 0.098
R-HSA-112316 Neuronal System 0.801834 0.096
R-HSA-5619115 Disorders of transmembrane transporters 0.805736 0.094
R-HSA-9609646 HCMV Infection 0.809310 0.092
R-HSA-5688426 Deubiquitination 0.815122 0.089
R-HSA-388841 Regulation of T cell activation by CD28 family 0.816263 0.088
R-HSA-556833 Metabolism of lipids 0.822706 0.085
R-HSA-168249 Innate Immune System 0.839480 0.076
R-HSA-9658195 Leishmania infection 0.842632 0.074
R-HSA-9824443 Parasitic Infection Pathways 0.842632 0.074
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.843605 0.074
R-HSA-1483257 Phospholipid metabolism 0.855725 0.068
R-HSA-112315 Transmission across Chemical Synapses 0.878761 0.056
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.902087 0.045
R-HSA-196854 Metabolism of vitamins and cofactors 0.906076 0.043
R-HSA-1280215 Cytokine Signaling in Immune system 0.906883 0.042
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.917093 0.038
R-HSA-425407 SLC-mediated transmembrane transport 0.924034 0.034
R-HSA-418594 G alpha (i) signalling events 0.928637 0.032
R-HSA-8978868 Fatty acid metabolism 0.928637 0.032
R-HSA-168256 Immune System 0.934264 0.030
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.947162 0.024
R-HSA-388396 GPCR downstream signalling 0.957369 0.019
R-HSA-109582 Hemostasis 0.959571 0.018
R-HSA-1280218 Adaptive Immune System 0.961475 0.017
R-HSA-211859 Biological oxidations 0.965538 0.015
R-HSA-422475 Axon guidance 0.970000 0.013
R-HSA-372790 Signaling by GPCR 0.972668 0.012
R-HSA-9675108 Nervous system development 0.976251 0.010
R-HSA-597592 Post-translational protein modification 0.979918 0.009
R-HSA-71291 Metabolism of amino acids and derivatives 0.981091 0.008
R-HSA-449147 Signaling by Interleukins 0.981911 0.008
R-HSA-382551 Transport of small molecules 0.998156 0.001
R-HSA-392499 Metabolism of proteins 0.998182 0.001
R-HSA-1430728 Metabolism 0.999301 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.781 0.355 1 0.858
KISKIS 0.771 0.302 1 0.841
CLK2CLK2 0.770 0.327 -3 0.703
HIPK4HIPK4 0.769 0.301 1 0.861
SRPK1SRPK1 0.763 0.197 -3 0.724
DYRK4DYRK4 0.763 0.369 1 0.811
DYRK2DYRK2 0.759 0.315 1 0.847
COTCOT 0.755 0.075 2 0.420
HIPK2HIPK2 0.752 0.275 1 0.804
CDK1CDK1 0.752 0.238 1 0.820
NDR2NDR2 0.749 0.081 -3 0.778
PIM3PIM3 0.748 0.082 -3 0.782
SRPK2SRPK2 0.747 0.141 -3 0.656
MTORMTOR 0.747 0.128 1 0.779
JNK2JNK2 0.746 0.273 1 0.813
CDK18CDK18 0.746 0.236 1 0.806
CDK19CDK19 0.746 0.227 1 0.819
NLKNLK 0.745 0.151 1 0.886
P38DP38D 0.745 0.291 1 0.793
SKMLCKSKMLCK 0.744 0.120 -2 0.801
PRKD1PRKD1 0.744 0.125 -3 0.782
CLK4CLK4 0.744 0.203 -3 0.735
CLK1CLK1 0.743 0.202 -3 0.718
CDK8CDK8 0.743 0.206 1 0.840
P38BP38B 0.743 0.269 1 0.804
CDK3CDK3 0.743 0.199 1 0.779
ATRATR 0.741 0.107 1 0.836
CDK5CDK5 0.741 0.182 1 0.856
RSK2RSK2 0.740 0.070 -3 0.744
CDKL1CDKL1 0.740 0.086 -3 0.781
ICKICK 0.740 0.135 -3 0.806
MOSMOS 0.740 0.055 1 0.755
PRKD2PRKD2 0.740 0.114 -3 0.733
CDK7CDK7 0.740 0.190 1 0.846
HIPK1HIPK1 0.740 0.231 1 0.854
CDKL5CDKL5 0.739 0.080 -3 0.776
GCN2GCN2 0.739 -0.023 2 0.374
CDK13CDK13 0.739 0.194 1 0.829
CDC7CDC7 0.739 -0.026 1 0.729
JNK3JNK3 0.739 0.243 1 0.826
ERK5ERK5 0.738 0.093 1 0.818
ERK1ERK1 0.738 0.220 1 0.808
CDK17CDK17 0.737 0.218 1 0.767
PRPKPRPK 0.737 -0.028 -1 0.731
CHAK2CHAK2 0.737 0.038 -1 0.791
PIM1PIM1 0.737 0.075 -3 0.745
P38AP38A 0.737 0.242 1 0.849
P90RSKP90RSK 0.737 0.060 -3 0.742
SRPK3SRPK3 0.736 0.115 -3 0.701
P38GP38G 0.736 0.229 1 0.765
NDR1NDR1 0.736 0.024 -3 0.788
GRK1GRK1 0.736 0.039 -2 0.762
DYRK1ADYRK1A 0.735 0.197 1 0.867
CDK10CDK10 0.735 0.213 1 0.824
CAMK1BCAMK1B 0.734 0.029 -3 0.833
IKKBIKKB 0.734 -0.022 -2 0.709
RIPK3RIPK3 0.733 -0.008 3 0.514
RAF1RAF1 0.733 0.025 1 0.744
CAMK2GCAMK2G 0.733 -0.050 2 0.382
DYRK1BDYRK1B 0.733 0.235 1 0.825
CDK12CDK12 0.732 0.186 1 0.814
CDK9CDK9 0.732 0.186 1 0.833
AURCAURC 0.731 0.051 -2 0.570
DSTYKDSTYK 0.731 0.002 2 0.430
TBK1TBK1 0.731 -0.043 1 0.653
CDK14CDK14 0.731 0.207 1 0.831
ULK2ULK2 0.730 -0.118 2 0.334
LATS2LATS2 0.730 0.022 -5 0.701
WNK1WNK1 0.730 -0.007 -2 0.841
RSK3RSK3 0.730 0.033 -3 0.740
IKKAIKKA 0.730 0.004 -2 0.705
HIPK3HIPK3 0.729 0.204 1 0.846
NUAK2NUAK2 0.729 0.033 -3 0.799
CAMLCKCAMLCK 0.729 0.026 -2 0.771
PKCDPKCD 0.729 -0.002 2 0.331
PKN2PKN2 0.729 0.005 -3 0.804
CDK2CDK2 0.729 0.131 1 0.848
MARK4MARK4 0.728 0.006 4 0.778
RSK4RSK4 0.728 0.070 -3 0.694
PKN3PKN3 0.728 -0.020 -3 0.784
BMPR2BMPR2 0.728 -0.030 -2 0.816
IKKEIKKE 0.728 -0.034 1 0.646
ERK2ERK2 0.728 0.185 1 0.839
MSK1MSK1 0.728 0.076 -3 0.733
HUNKHUNK 0.728 -0.012 2 0.443
MST4MST4 0.728 -0.030 2 0.372
DYRK3DYRK3 0.727 0.202 1 0.844
PAK1PAK1 0.727 0.006 -2 0.720
DAPK2DAPK2 0.727 0.040 -3 0.836
CAMK2ACAMK2A 0.727 0.061 2 0.418
PDHK4PDHK4 0.727 -0.133 1 0.781
CDK16CDK16 0.727 0.201 1 0.780
MASTLMASTL 0.727 -0.067 -2 0.796
P70S6KBP70S6KB 0.727 0.027 -3 0.770
DNAPKDNAPK 0.726 0.128 1 0.768
NIKNIK 0.726 -0.020 -3 0.840
NIM1NIM1 0.726 -0.052 3 0.500
SMG1SMG1 0.725 0.096 1 0.815
MLK2MLK2 0.725 -0.027 2 0.353
CAMK2DCAMK2D 0.725 -0.003 -3 0.813
NEK6NEK6 0.725 -0.067 -2 0.792
ULK1ULK1 0.725 -0.101 -3 0.790
JNK1JNK1 0.725 0.219 1 0.797
PKACGPKACG 0.724 0.009 -2 0.666
MLK1MLK1 0.724 -0.099 2 0.364
PASKPASK 0.724 0.195 -3 0.801
MLK3MLK3 0.723 -0.038 2 0.323
PKACBPKACB 0.723 0.059 -2 0.593
LATS1LATS1 0.723 0.077 -3 0.794
GRK5GRK5 0.722 -0.086 -3 0.813
TGFBR2TGFBR2 0.722 -0.054 -2 0.709
MNK1MNK1 0.722 0.024 -2 0.719
ATMATM 0.722 0.068 1 0.795
PRP4PRP4 0.722 0.161 -3 0.705
MAPKAPK2MAPKAPK2 0.722 0.044 -3 0.702
PAK3PAK3 0.721 -0.027 -2 0.718
PKCBPKCB 0.721 -0.016 2 0.312
CAMK2BCAMK2B 0.721 0.014 2 0.380
FAM20CFAM20C 0.721 -0.049 2 0.272
BMPR1BBMPR1B 0.720 0.095 1 0.676
PDHK1PDHK1 0.720 -0.156 1 0.753
DLKDLK 0.720 -0.004 1 0.745
MAPKAPK3MAPKAPK3 0.720 0.025 -3 0.749
NEK7NEK7 0.720 -0.134 -3 0.805
MSK2MSK2 0.720 0.017 -3 0.724
QSKQSK 0.719 0.016 4 0.754
DRAK1DRAK1 0.719 0.119 1 0.700
GRK7GRK7 0.719 0.023 1 0.694
AMPKA1AMPKA1 0.719 -0.046 -3 0.809
PKCAPKCA 0.718 -0.023 2 0.305
MNK2MNK2 0.718 -0.003 -2 0.722
GSK3AGSK3A 0.717 0.099 4 0.549
ERK7ERK7 0.717 0.042 2 0.222
PRKXPRKX 0.717 0.057 -3 0.638
GRK6GRK6 0.717 -0.044 1 0.722
RIPK1RIPK1 0.717 -0.093 1 0.732
PKCGPKCG 0.717 -0.035 2 0.330
IRE1IRE1 0.717 -0.095 1 0.719
MARK3MARK3 0.716 0.047 4 0.726
WNK3WNK3 0.716 -0.165 1 0.740
AMPKA2AMPKA2 0.716 -0.026 -3 0.779
ANKRD3ANKRD3 0.716 -0.108 1 0.768
PKCZPKCZ 0.716 -0.024 2 0.329
PAK6PAK6 0.716 -0.005 -2 0.628
MYLK4MYLK4 0.716 0.043 -2 0.685
PRKD3PRKD3 0.716 0.030 -3 0.719
TSSK2TSSK2 0.716 -0.038 -5 0.735
TGFBR1TGFBR1 0.716 0.035 -2 0.733
YSK4YSK4 0.716 0.013 1 0.696
MAKMAK 0.716 0.181 -2 0.729
CDK6CDK6 0.715 0.171 1 0.819
AURBAURB 0.715 0.006 -2 0.568
PIM2PIM2 0.714 0.046 -3 0.725
IRE2IRE2 0.714 -0.094 2 0.300
TSSK1TSSK1 0.714 -0.032 -3 0.818
ALK4ALK4 0.714 -0.001 -2 0.758
GRK4GRK4 0.714 -0.085 -2 0.757
GSK3BGSK3B 0.714 0.065 4 0.538
AKT2AKT2 0.713 0.043 -3 0.668
NEK9NEK9 0.713 -0.136 2 0.353
PAK2PAK2 0.713 -0.039 -2 0.705
CDK4CDK4 0.712 0.175 1 0.808
PKRPKR 0.712 -0.038 1 0.756
VRK2VRK2 0.712 -0.072 1 0.806
TLK2TLK2 0.712 -0.004 1 0.756
PLK3PLK3 0.712 -0.014 2 0.419
PKCHPKCH 0.712 -0.057 2 0.307
MEK1MEK1 0.712 -0.039 2 0.415
NUAK1NUAK1 0.712 -0.026 -3 0.754
PLK1PLK1 0.712 -0.063 -2 0.736
MLK4MLK4 0.711 -0.097 2 0.309
PHKG1PHKG1 0.711 -0.063 -3 0.780
CAMK4CAMK4 0.711 -0.057 -3 0.783
CHAK1CHAK1 0.710 -0.091 2 0.343
BCKDKBCKDK 0.710 -0.149 -1 0.638
MELKMELK 0.710 -0.056 -3 0.768
SIKSIK 0.710 -0.015 -3 0.733
BRSK2BRSK2 0.709 -0.046 -3 0.781
QIKQIK 0.709 -0.065 -3 0.806
SGK3SGK3 0.709 0.000 -3 0.740
PLK4PLK4 0.709 -0.094 2 0.310
BRSK1BRSK1 0.709 -0.037 -3 0.752
MST3MST3 0.708 0.017 2 0.408
TTBK2TTBK2 0.708 -0.176 2 0.309
DCAMKL1DCAMKL1 0.708 0.003 -3 0.737
PKG2PKG2 0.708 -0.012 -2 0.588
CAMK1GCAMK1G 0.708 0.009 -3 0.736
AURAAURA 0.707 0.004 -2 0.537
MARK2MARK2 0.707 -0.010 4 0.694
MPSK1MPSK1 0.705 0.031 1 0.736
ACVR2BACVR2B 0.705 0.014 -2 0.713
DCAMKL2DCAMKL2 0.705 -0.018 -3 0.767
SNRKSNRK 0.705 -0.125 2 0.314
NEK2NEK2 0.704 -0.096 2 0.344
CHK1CHK1 0.704 -0.013 -3 0.792
MARK1MARK1 0.703 -0.013 4 0.733
ALK2ALK2 0.703 0.011 -2 0.730
GAKGAK 0.702 0.118 1 0.769
MOKMOK 0.702 0.143 1 0.833
PKACAPKACA 0.701 0.021 -2 0.535
PKCEPKCE 0.700 -0.011 2 0.322
GRK2GRK2 0.700 -0.036 -2 0.643
ACVR2AACVR2A 0.700 -0.028 -2 0.699
NEK5NEK5 0.700 -0.053 1 0.760
TAO3TAO3 0.700 -0.022 1 0.737
STK33STK33 0.699 -0.051 2 0.316
P70S6KP70S6K 0.699 -0.008 -3 0.703
PKCTPKCT 0.699 -0.059 2 0.296
BMPR1ABMPR1A 0.699 0.041 1 0.648
PERKPERK 0.699 -0.099 -2 0.747
PINK1PINK1 0.699 -0.046 1 0.818
SMMLCKSMMLCK 0.698 0.006 -3 0.795
MEKK3MEKK3 0.698 -0.084 1 0.731
MEK5MEK5 0.698 -0.150 2 0.380
PKCIPKCI 0.698 -0.048 2 0.313
WNK4WNK4 0.698 -0.102 -2 0.843
IRAK4IRAK4 0.698 -0.121 1 0.720
BUB1BUB1 0.698 0.135 -5 0.705
GCKGCK 0.697 0.079 1 0.739
SLKSLK 0.697 0.070 -2 0.705
NEK11NEK11 0.697 -0.020 1 0.719
SSTKSSTK 0.697 -0.045 4 0.714
PAK4PAK4 0.696 -0.040 -2 0.588
AKT1AKT1 0.696 -0.000 -3 0.682
LKB1LKB1 0.696 0.036 -3 0.786
MAPKAPK5MAPKAPK5 0.695 -0.055 -3 0.713
CK1ECK1E 0.695 -0.037 -3 0.493
MEKK2MEKK2 0.695 -0.138 2 0.345
ZAKZAK 0.695 -0.133 1 0.689
PDHK3_TYRPDHK3_TYR 0.695 0.160 4 0.835
DAPK3DAPK3 0.694 0.017 -3 0.757
MEKK1MEKK1 0.694 -0.165 1 0.729
PAK5PAK5 0.693 -0.042 -2 0.592
TLK1TLK1 0.693 -0.072 -2 0.755
MRCKAMRCKA 0.692 0.041 -3 0.727
ROCK2ROCK2 0.692 0.048 -3 0.750
LOKLOK 0.692 0.010 -2 0.736
SGK1SGK1 0.691 0.027 -3 0.598
HPK1HPK1 0.691 0.042 1 0.725
PHKG2PHKG2 0.691 -0.088 -3 0.767
PLK2PLK2 0.690 -0.001 -3 0.751
BRAFBRAF 0.690 -0.129 -4 0.752
CAMKK1CAMKK1 0.690 -0.048 -2 0.703
DAPK1DAPK1 0.690 0.019 -3 0.748
HRIHRI 0.690 -0.169 -2 0.763
YANK3YANK3 0.690 -0.036 2 0.232
TNIKTNIK 0.689 -0.009 3 0.627
CK1DCK1D 0.689 -0.020 -3 0.445
PDK1PDK1 0.689 -0.063 1 0.712
MRCKBMRCKB 0.689 0.022 -3 0.715
AKT3AKT3 0.689 0.012 -3 0.608
PDHK4_TYRPDHK4_TYR 0.689 0.174 2 0.457
CAMK1DCAMK1D 0.688 -0.009 -3 0.653
MEKK6MEKK6 0.688 -0.056 1 0.727
CAMKK2CAMKK2 0.688 -0.021 -2 0.698
MST2MST2 0.688 -0.026 1 0.730
TAK1TAK1 0.688 0.014 1 0.746
HGKHGK 0.688 -0.050 3 0.627
TTBK1TTBK1 0.687 -0.150 2 0.280
TAO2TAO2 0.687 -0.088 2 0.362
MAP3K15MAP3K15 0.687 -0.061 1 0.691
CK1G1CK1G1 0.687 -0.068 -3 0.480
NEK8NEK8 0.686 -0.129 2 0.360
KHS2KHS2 0.686 0.017 1 0.736
CK2A2CK2A2 0.686 -0.032 1 0.586
KHS1KHS1 0.686 0.009 1 0.713
MAP2K6_TYRMAP2K6_TYR 0.686 0.152 -1 0.729
MINKMINK 0.685 -0.057 1 0.717
LIMK2_TYRLIMK2_TYR 0.685 0.070 -3 0.845
CHK2CHK2 0.685 0.010 -3 0.621
PKN1PKN1 0.685 -0.048 -3 0.716
EPHA6EPHA6 0.685 0.086 -1 0.722
TESK1_TYRTESK1_TYR 0.685 0.038 3 0.608
LRRK2LRRK2 0.684 -0.063 2 0.380
CK1A2CK1A2 0.684 -0.042 -3 0.446
NEK4NEK4 0.684 -0.095 1 0.726
GRK3GRK3 0.683 -0.055 -2 0.602
DMPK1DMPK1 0.683 0.051 -3 0.726
PKMYT1_TYRPKMYT1_TYR 0.683 0.003 3 0.599
MAP2K4_TYRMAP2K4_TYR 0.682 0.067 -1 0.731
EPHB4EPHB4 0.682 0.112 -1 0.704
MST1MST1 0.682 -0.015 1 0.715
CK2A1CK2A1 0.682 -0.013 1 0.571
EEF2KEEF2K 0.681 -0.088 3 0.551
PBKPBK 0.681 0.021 1 0.699
SBKSBK 0.681 0.051 -3 0.561
BMPR2_TYRBMPR2_TYR 0.680 0.069 -1 0.723
PDHK1_TYRPDHK1_TYR 0.680 0.047 -1 0.747
MAP2K7_TYRMAP2K7_TYR 0.680 -0.040 2 0.412
NEK1NEK1 0.679 -0.074 1 0.722
TNK2TNK2 0.679 0.042 3 0.560
VRK1VRK1 0.679 -0.102 2 0.382
CRIKCRIK 0.679 0.048 -3 0.684
EPHA4EPHA4 0.679 0.107 2 0.452
IRAK1IRAK1 0.679 -0.215 -1 0.629
ABL2ABL2 0.677 0.113 -1 0.670
TXKTXK 0.677 0.117 1 0.716
OSR1OSR1 0.676 -0.020 2 0.354
CAMK1ACAMK1A 0.675 -0.019 -3 0.633
PINK1_TYRPINK1_TYR 0.675 -0.111 1 0.764
MEK2MEK2 0.674 -0.138 2 0.362
ROCK1ROCK1 0.674 0.018 -3 0.724
ABL1ABL1 0.674 0.099 -1 0.667
MST1RMST1R 0.674 -0.011 3 0.599
RETRET 0.673 -0.007 1 0.733
ITKITK 0.673 0.105 -1 0.685
YSK1YSK1 0.673 -0.112 2 0.334
TYRO3TYRO3 0.673 -0.041 3 0.569
CSF1RCSF1R 0.672 0.008 3 0.583
SRMSSRMS 0.672 0.096 1 0.723
YES1YES1 0.672 -0.003 -1 0.748
PTK2BPTK2B 0.671 0.124 -1 0.672
EPHB3EPHB3 0.670 0.061 -1 0.690
RIPK2RIPK2 0.670 -0.175 1 0.656
BLKBLK 0.670 0.046 -1 0.720
DDR1DDR1 0.670 -0.043 4 0.738
HASPINHASPIN 0.670 -0.036 -1 0.603
LCKLCK 0.669 0.029 -1 0.723
EPHB2EPHB2 0.669 0.063 -1 0.684
EPHB1EPHB1 0.669 0.040 1 0.719
FGRFGR 0.668 -0.020 1 0.750
TEKTEK 0.668 0.005 3 0.515
MERTKMERTK 0.667 0.017 3 0.554
ROS1ROS1 0.667 -0.143 3 0.529
HCKHCK 0.667 -0.021 -1 0.718
KITKIT 0.667 0.026 3 0.586
BMXBMX 0.667 0.061 -1 0.624
JAK2JAK2 0.667 -0.094 1 0.720
LIMK1_TYRLIMK1_TYR 0.667 -0.131 2 0.362
EPHA7EPHA7 0.667 0.031 2 0.425
EPHA3EPHA3 0.666 0.028 2 0.412
PTK2PTK2 0.666 0.100 -1 0.656
FGFR2FGFR2 0.666 -0.034 3 0.550
MYO3BMYO3B 0.666 -0.056 2 0.346
FYNFYN 0.665 0.053 -1 0.713
TNK1TNK1 0.665 -0.056 3 0.560
ASK1ASK1 0.665 -0.078 1 0.672
TTKTTK 0.665 -0.096 -2 0.741
AXLAXL 0.665 -0.035 3 0.555
PKG1PKG1 0.665 -0.056 -2 0.512
JAK3JAK3 0.664 -0.051 1 0.714
FERFER 0.664 -0.060 1 0.750
TECTEC 0.664 0.024 -1 0.649
INSRRINSRR 0.663 -0.089 3 0.506
KDRKDR 0.663 -0.049 3 0.538
DDR2DDR2 0.663 0.025 3 0.500
EPHA5EPHA5 0.663 0.069 2 0.439
TYK2TYK2 0.662 -0.207 1 0.718
NEK3NEK3 0.661 -0.142 1 0.694
FLT3FLT3 0.661 -0.069 3 0.579
METMET 0.661 0.001 3 0.594
MYO3AMYO3A 0.661 -0.095 1 0.711
BIKEBIKE 0.661 -0.005 1 0.664
CK1ACK1A 0.660 -0.047 -3 0.353
FRKFRK 0.660 0.003 -1 0.722
FGFR1FGFR1 0.660 -0.088 3 0.523
NEK10_TYRNEK10_TYR 0.660 -0.056 1 0.650
FGFR3FGFR3 0.659 -0.019 3 0.530
EPHA1EPHA1 0.659 -0.007 3 0.579
LYNLYN 0.658 -0.006 3 0.514
EPHA8EPHA8 0.658 0.019 -1 0.670
PDGFRBPDGFRB 0.657 -0.165 3 0.573
BTKBTK 0.656 -0.054 -1 0.670
TAO1TAO1 0.656 -0.100 1 0.666
FLT1FLT1 0.655 -0.005 -1 0.671
WEE1_TYRWEE1_TYR 0.655 -0.075 -1 0.640
JAK1JAK1 0.654 -0.124 1 0.670
TNNI3K_TYRTNNI3K_TYR 0.653 -0.110 1 0.718
SRCSRC 0.653 -0.015 -1 0.708
EPHA2EPHA2 0.653 0.050 -1 0.629
YANK2YANK2 0.653 -0.060 2 0.226
LTKLTK 0.652 -0.122 3 0.507
ALPHAK3ALPHAK3 0.652 -0.064 -1 0.637
ERBB2ERBB2 0.651 -0.089 1 0.669
PTK6PTK6 0.651 -0.142 -1 0.620
PDGFRAPDGFRA 0.651 -0.178 3 0.579
ALKALK 0.650 -0.157 3 0.490
MATKMATK 0.650 -0.036 -1 0.598
CSKCSK 0.650 -0.031 2 0.411
NTRK1NTRK1 0.649 -0.130 -1 0.664
FLT4FLT4 0.649 -0.102 3 0.515
INSRINSR 0.649 -0.138 3 0.504
AAK1AAK1 0.649 0.026 1 0.587
FGFR4FGFR4 0.648 -0.029 -1 0.622
STLK3STLK3 0.646 -0.145 1 0.675
SYKSYK 0.645 0.046 -1 0.628
NTRK2NTRK2 0.645 -0.170 3 0.542
NTRK3NTRK3 0.645 -0.108 -1 0.622
EGFREGFR 0.641 -0.063 1 0.580
ERBB4ERBB4 0.639 -0.020 1 0.589
ZAP70ZAP70 0.638 0.061 -1 0.559
IGF1RIGF1R 0.637 -0.128 3 0.458
MUSKMUSK 0.633 -0.113 1 0.579
FESFES 0.630 -0.076 -1 0.602
CK1G3CK1G3 0.627 -0.075 -3 0.305
CK1G2CK1G2 0.625 -0.050 -3 0.396