Motif 359 (n=90)
Position-wise Probabilities
Download
uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A1L390 | PLEKHG3 | S1079 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
A4D1P6 | WDR91 | S272 | ochoa | WD repeat-containing protein 91 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. |
A6NKT7 | RGPD3 | S393 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
H0YIS7 | RNASEK-C17orf49 | S160 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
O14497 | ARID1A | Y762 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
O14686 | KMT2D | S2309 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14686 | KMT2D | S4617 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O15047 | SETD1A | S532 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
O43561 | LAT | S131 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
O60245 | PCDH7 | S998 | ochoa | Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) | None |
O60296 | TRAK2 | Y755 | ochoa | Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) | May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}. |
O60307 | MAST3 | S1180 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
O60673 | REV3L | S2171 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
O75420 | GIGYF1 | S366 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O75420 | GIGYF1 | S368 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O75427 | LRCH4 | S279 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
O75665 | OFD1 | S762 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
O94868 | FCHSD2 | S644 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
P03372 | ESR1 | S104 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
P23497 | SP100 | S189 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
P26651 | ZFP36 | S188 | ochoa | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
P31150 | GDI1 | S222 | ochoa | Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4) | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}. |
P36873 | PPP1CC | S48 | ochoa | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
P42694 | HELZ | S1247 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
P49792 | RANBP2 | S392 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P49815 | TSC2 | S1252 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
P50395 | GDI2 | S222 | ochoa | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
P62136 | PPP1CA | S48 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
P62140 | PPP1CB | S47 | ochoa | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
P78524 | DENND2B | S30 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
P98174 | FGD1 | S114 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
Q02410 | APBA1 | S246 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
Q08174 | PCDH1 | S971 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
Q13470 | TNK1 | S500 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
Q14676 | MDC1 | S964 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q15365 | PCBP1 | S171 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
Q15366 | PCBP2 | S171 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
Q15648 | MED1 | Y1431 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
Q15758 | SLC1A5 | S491 | ochoa | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}. |
Q5D1E8 | ZC3H12A | S99 | ochoa | Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) | Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:22561375, PubMed:26134560, PubMed:26320658). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q5D1E7, ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18364357, ECO:0000269|PubMed:19185603, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:22561375, ECO:0000269|PubMed:24048733, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:26134560, ECO:0000269|PubMed:26320658}.; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. {ECO:0000269|PubMed:23355615}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. {ECO:0000269|PubMed:24191027}. |
Q5SXM2 | SNAPC4 | S1161 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
Q5SYE7 | NHSL1 | S725 | ochoa | NHS-like protein 1 | None |
Q5SYE7 | NHSL1 | S1274 | ochoa | NHS-like protein 1 | None |
Q5T3I0 | GPATCH4 | S89 | ochoa | G patch domain-containing protein 4 | None |
Q5T5P2 | KIAA1217 | S1877 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
Q5VT52 | RPRD2 | S436 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
Q63ZY3 | KANK2 | S155 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
Q6IAA8 | LAMTOR1 | S96 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
Q6NUJ5 | PWWP2B | S456 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
Q7Z3J3 | RGPD4 | S393 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q8IXM2 | BACC1 | S119 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
Q8IZD0 | SAMD14 | S54 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
Q8N163 | CCAR2 | S611 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
Q8N1G0 | ZNF687 | S251 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
Q8N4C8 | MINK1 | S916 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
Q8NC74 | RBBP8NL | S464 | ochoa | RBBP8 N-terminal-like protein | None |
Q8WXE0 | CASKIN2 | S368 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
Q8WXI9 | GATAD2B | S495 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
Q92793 | CREBBP | S90 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
Q92934 | BAD | S32 | ochoa | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
Q96A00 | PPP1R14A | S128 | ochoa | Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17) | Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. |
Q96BH1 | RNF25 | S295 | ochoa | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951216). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (PubMed:36638793). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (PubMed:36638793, PubMed:37651229). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (PubMed:12748188). {ECO:0000250|UniProtKB:Q9QZR0, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951216}. |
Q96EV2 | RBM33 | S849 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
Q96HC4 | PDLIM5 | S360 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
Q96KV7 | WDR90 | S239 | ochoa | WD repeat-containing protein 90 | Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability (PubMed:32946374). Required for efficient primary cilium formation (PubMed:28781053). {ECO:0000269|PubMed:28781053}. |
Q9BV36 | MLPH | S264 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
Q9BV36 | MLPH | S266 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
Q9BVG8 | KIFC3 | S781 | ochoa | Kinesin-like protein KIFC3 | Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269|PubMed:19041755}. |
Q9C0C2 | TNKS1BP1 | S1138 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0K0 | BCL11B | S256 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
Q9H2P0 | ADNP | S424 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
Q9H9E1 | ANKRA2 | S104 | ochoa | Ankyrin repeat family A protein 2 (RFXANK-like protein 2) | May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000269|PubMed:25752541}. |
Q9HCD5 | NCOA5 | S448 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
Q9NQS1 | AVEN | S261 | ochoa | Cell death regulator Aven | Protects against apoptosis mediated by Apaf-1. |
Q9NUQ6 | SPATS2L | Y361 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
Q9NZ53 | PODXL2 | S558 | ochoa | Podocalyxin-like protein 2 (Endoglycan) | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}. |
Q9NZQ3 | NCKIPSD | Y161 | psp | NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) | Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. |
Q9P2F8 | SIPA1L2 | S1520 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
Q9UBF8 | PI4KB | S256 | ochoa | Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}. |
Q9UBP9 | GULP1 | S211 | ochoa | PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) | May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}. |
Q9UHK6 | AMACR | S324 | ochoa | Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) | Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:10655068, PubMed:11060359, PubMed:7649182). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:10655068, PubMed:11060359, PubMed:7649182). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}. |
Q9UI36 | DACH1 | S491 | psp | Dachshund homolog 1 (Dach1) | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269|PubMed:14525983}. |
Q9ULD2 | MTUS1 | S181 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
Q9UMS6 | SYNPO2 | S224 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9Y4F1 | FARP1 | S861 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
Q9Y4H2 | IRS2 | S770 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
P11586 | MTHFD1 | S870 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
Q5T1R4 | HIVEP3 | S1678 | Sugiyama | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
P36894 | BMPR1A | S213 | Sugiyama | Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}. |
P08151 | GLI1 | Y925 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.000139 | 3.857 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.000168 | 3.775 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.000708 | 3.150 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.000707 | 3.151 |
R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.001136 | 2.944 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.001762 | 2.754 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.002123 | 2.673 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.002123 | 2.673 |
R-HSA-9909396 | Circadian clock | 0.002195 | 2.659 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.001707 | 2.768 |
R-HSA-163560 | Triglyceride catabolism | 0.002397 | 2.620 |
R-HSA-9828806 | Maturation of hRSV A proteins | 0.001132 | 2.946 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.001621 | 2.790 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.002603 | 2.585 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.002896 | 2.538 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.003882 | 2.411 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.003861 | 2.413 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.004075 | 2.390 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.004404 | 2.356 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.006138 | 2.212 |
R-HSA-4839726 | Chromatin organization | 0.006191 | 2.208 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.007439 | 2.128 |
R-HSA-162582 | Signal Transduction | 0.007210 | 2.142 |
R-HSA-9007101 | Rab regulation of trafficking | 0.008634 | 2.064 |
R-HSA-8979227 | Triglyceride metabolism | 0.008165 | 2.088 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.010049 | 1.998 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.009788 | 2.009 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.010378 | 1.984 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.012158 | 1.915 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.013748 | 1.862 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.015586 | 1.807 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.015586 | 1.807 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.015902 | 1.799 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.020060 | 1.698 |
R-HSA-8939211 | ESR-mediated signaling | 0.020738 | 1.683 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.021289 | 1.672 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.020613 | 1.686 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.018660 | 1.729 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.017545 | 1.756 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.020613 | 1.686 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.019832 | 1.703 |
R-HSA-9006936 | Signaling by TGFB family members | 0.023763 | 1.624 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.026219 | 1.581 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.027407 | 1.562 |
R-HSA-5673000 | RAF activation | 0.026219 | 1.581 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.026219 | 1.581 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.029975 | 1.523 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.029975 | 1.523 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.031402 | 1.503 |
R-HSA-5610787 | Hedgehog 'off' state | 0.030700 | 1.513 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.029543 | 1.530 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.028644 | 1.543 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.032367 | 1.490 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.034970 | 1.456 |
R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.035863 | 1.445 |
R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.035863 | 1.445 |
R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.041715 | 1.380 |
R-HSA-74713 | IRS activation | 0.041715 | 1.380 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 0.053314 | 1.273 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.059061 | 1.229 |
R-HSA-112412 | SOS-mediated signalling | 0.059061 | 1.229 |
R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.070452 | 1.152 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.076096 | 1.119 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.087283 | 1.059 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.092827 | 1.032 |
R-HSA-9027284 | Erythropoietin activates RAS | 0.109257 | 0.962 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.109257 | 0.962 |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.109257 | 0.962 |
R-HSA-5656121 | Translesion synthesis by POLI | 0.114668 | 0.941 |
R-HSA-5655862 | Translesion synthesis by POLK | 0.120046 | 0.921 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.037651 | 1.424 |
R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.156800 | 0.805 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.064959 | 1.187 |
R-HSA-9006335 | Signaling by Erythropoietin | 0.192034 | 0.717 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.196947 | 0.706 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.201831 | 0.695 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.201831 | 0.695 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.211510 | 0.675 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.211510 | 0.675 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.216305 | 0.665 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.225810 | 0.646 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.096978 | 1.013 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.244480 | 0.612 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.112385 | 0.949 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.112385 | 0.949 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.249077 | 0.604 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.098336 | 1.007 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.114354 | 0.942 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.067205 | 1.173 |
R-HSA-198203 | PI3K/AKT activation | 0.076096 | 1.119 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.177116 | 0.752 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.054412 | 1.264 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.054412 | 1.264 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.120046 | 0.921 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.054412 | 1.264 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.092827 | 1.032 |
R-HSA-2424491 | DAP12 signaling | 0.196947 | 0.706 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.103813 | 0.984 |
R-HSA-110312 | Translesion synthesis by REV1 | 0.109257 | 0.962 |
R-HSA-202433 | Generation of second messenger molecules | 0.249077 | 0.604 |
R-HSA-165159 | MTOR signalling | 0.037651 | 1.424 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.157505 | 0.803 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.157505 | 0.803 |
R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.087283 | 1.059 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.216305 | 0.665 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.146955 | 0.833 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.138629 | 0.858 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.053314 | 1.273 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.087283 | 1.059 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.156800 | 0.805 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.085863 | 1.066 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.216305 | 0.665 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.235201 | 0.629 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.249077 | 0.604 |
R-HSA-201451 | Signaling by BMP | 0.182119 | 0.740 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.198713 | 0.702 |
R-HSA-9843745 | Adipogenesis | 0.061142 | 1.214 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.092827 | 1.032 |
R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.064774 | 1.189 |
R-HSA-74749 | Signal attenuation | 0.076096 | 1.119 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.108475 | 0.965 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.084988 | 1.071 |
R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.047532 | 1.323 |
R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.064774 | 1.189 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.156800 | 0.805 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.216305 | 0.665 |
R-HSA-68877 | Mitotic Prometaphase | 0.139550 | 0.855 |
R-HSA-5632684 | Hedgehog 'on' state | 0.084051 | 1.075 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.078688 | 1.104 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.249077 | 0.604 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.249077 | 0.604 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.166045 | 0.780 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.196947 | 0.706 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.235201 | 0.629 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.053314 | 1.273 |
R-HSA-193648 | NRAGE signals death through JNK | 0.058435 | 1.233 |
R-HSA-180746 | Nuclear import of Rev protein | 0.221072 | 0.655 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.151157 | 0.821 |
R-HSA-5358351 | Signaling by Hedgehog | 0.069285 | 1.159 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.120046 | 0.921 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.064959 | 1.187 |
R-HSA-114452 | Activation of BH3-only proteins | 0.196947 | 0.706 |
R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.070452 | 1.152 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.114668 | 0.941 |
R-HSA-166208 | mTORC1-mediated signalling | 0.156800 | 0.805 |
R-HSA-429947 | Deadenylation of mRNA | 0.167019 | 0.777 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.249077 | 0.604 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.249077 | 0.604 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.230520 | 0.637 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.061667 | 1.210 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.230520 | 0.637 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.041815 | 1.379 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.249077 | 0.604 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.041715 | 1.380 |
R-HSA-111458 | Formation of apoptosome | 0.076096 | 1.119 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.130706 | 0.884 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.211510 | 0.675 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.239854 | 0.620 |
R-HSA-3371568 | Attenuation phase | 0.249077 | 0.604 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.168193 | 0.774 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.182119 | 0.740 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.167019 | 0.777 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.177116 | 0.752 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.151157 | 0.821 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.066627 | 1.176 |
R-HSA-3371556 | Cellular response to heat stress | 0.049838 | 1.302 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.134506 | 0.871 |
R-HSA-9627069 | Regulation of the apoptosome activity | 0.076096 | 1.119 |
R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.087283 | 1.059 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.120046 | 0.921 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.201831 | 0.695 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.244480 | 0.612 |
R-HSA-196757 | Metabolism of folate and pterines | 0.235201 | 0.629 |
R-HSA-6794361 | Neurexins and neuroligins | 0.052158 | 1.283 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.201831 | 0.695 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.183356 | 0.737 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.076096 | 1.119 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.058435 | 1.233 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.196947 | 0.706 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.203130 | 0.692 |
R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.059061 | 1.229 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.146457 | 0.834 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.087687 | 1.057 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.146457 | 0.834 |
R-HSA-9833110 | RSV-host interactions | 0.157505 | 0.803 |
R-HSA-74160 | Gene expression (Transcription) | 0.054697 | 1.262 |
R-HSA-2586552 | Signaling by Leptin | 0.076096 | 1.119 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.221072 | 0.655 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.239911 | 0.620 |
R-HSA-5662702 | Melanin biosynthesis | 0.141238 | 0.850 |
R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.172083 | 0.764 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.110426 | 0.957 |
R-HSA-180024 | DARPP-32 events | 0.192034 | 0.717 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.182119 | 0.740 |
R-HSA-212436 | Generic Transcription Pathway | 0.053435 | 1.272 |
R-HSA-111471 | Apoptotic factor-mediated response | 0.130706 | 0.884 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.156800 | 0.805 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.070005 | 1.155 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.211510 | 0.675 |
R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 0.225810 | 0.646 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.235201 | 0.629 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.235201 | 0.629 |
R-HSA-6807070 | PTEN Regulation | 0.245536 | 0.610 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.194308 | 0.712 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.211510 | 0.675 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.169826 | 0.770 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.098869 | 1.005 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.151157 | 0.821 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.106534 | 0.973 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.110426 | 0.957 |
R-HSA-8853659 | RET signaling | 0.230520 | 0.637 |
R-HSA-9707616 | Heme signaling | 0.068309 | 1.166 |
R-HSA-114604 | GPVI-mediated activation cascade | 0.230520 | 0.637 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.144864 | 0.839 |
R-HSA-1266695 | Interleukin-7 signaling | 0.172083 | 0.764 |
R-HSA-982772 | Growth hormone receptor signaling | 0.161925 | 0.791 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.102681 | 0.989 |
R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.221072 | 0.655 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.189916 | 0.721 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.120139 | 0.920 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.127414 | 0.895 |
R-HSA-5683057 | MAPK family signaling cascades | 0.185495 | 0.732 |
R-HSA-1632852 | Macroautophagy | 0.250030 | 0.602 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.253646 | 0.596 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.253646 | 0.596 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.253646 | 0.596 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.253646 | 0.596 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.254527 | 0.594 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.258188 | 0.588 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.258188 | 0.588 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.262703 | 0.581 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.262703 | 0.581 |
R-HSA-73928 | Depyrimidination | 0.262703 | 0.581 |
R-HSA-8854214 | TBC/RABGAPs | 0.267190 | 0.573 |
R-HSA-2172127 | DAP12 interactions | 0.271651 | 0.566 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.271651 | 0.566 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.272528 | 0.565 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.274185 | 0.562 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.276084 | 0.559 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.280491 | 0.552 |
R-HSA-73887 | Death Receptor Signaling | 0.281527 | 0.550 |
R-HSA-1989781 | PPARA activates gene expression | 0.283775 | 0.547 |
R-HSA-9612973 | Autophagy | 0.286024 | 0.544 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.288271 | 0.540 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.289225 | 0.539 |
R-HSA-877300 | Interferon gamma signaling | 0.292764 | 0.533 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.293553 | 0.532 |
R-HSA-73893 | DNA Damage Bypass | 0.293553 | 0.532 |
R-HSA-109704 | PI3K Cascade | 0.297855 | 0.526 |
R-HSA-2262752 | Cellular responses to stress | 0.298222 | 0.525 |
R-HSA-109581 | Apoptosis | 0.299497 | 0.524 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.302130 | 0.520 |
R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.302130 | 0.520 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.303981 | 0.517 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.306380 | 0.514 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.306380 | 0.514 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.310604 | 0.508 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.314803 | 0.502 |
R-HSA-3214815 | HDACs deacetylate histones | 0.318977 | 0.496 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.318977 | 0.496 |
R-HSA-112399 | IRS-mediated signalling | 0.327248 | 0.485 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.327248 | 0.485 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.327248 | 0.485 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.335420 | 0.474 |
R-HSA-191859 | snRNP Assembly | 0.335420 | 0.474 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.335420 | 0.474 |
R-HSA-9033241 | Peroxisomal protein import | 0.335420 | 0.474 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.335420 | 0.474 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 0.335420 | 0.474 |
R-HSA-186712 | Regulation of beta-cell development | 0.335420 | 0.474 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.339470 | 0.469 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.339470 | 0.469 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.339470 | 0.469 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.339470 | 0.469 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.339470 | 0.469 |
R-HSA-2559583 | Cellular Senescence | 0.341844 | 0.466 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.342232 | 0.466 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.343494 | 0.464 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.343494 | 0.464 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.343494 | 0.464 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.347495 | 0.459 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.348467 | 0.458 |
R-HSA-8957322 | Metabolism of steroids | 0.348884 | 0.457 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.351471 | 0.454 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.351471 | 0.454 |
R-HSA-69275 | G2/M Transition | 0.355068 | 0.450 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.355423 | 0.449 |
R-HSA-2428924 | IGF1R signaling cascade | 0.355423 | 0.449 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.359352 | 0.444 |
R-HSA-1234174 | Cellular response to hypoxia | 0.359352 | 0.444 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.359456 | 0.444 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.363257 | 0.440 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.363257 | 0.440 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.367138 | 0.435 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.367138 | 0.435 |
R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.367138 | 0.435 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.372556 | 0.429 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.376899 | 0.424 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.378642 | 0.422 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.378642 | 0.422 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.378642 | 0.422 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.382430 | 0.417 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.382430 | 0.417 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.386196 | 0.413 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.386196 | 0.413 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.389939 | 0.409 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.389939 | 0.409 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.393659 | 0.405 |
R-HSA-1236394 | Signaling by ERBB4 | 0.393659 | 0.405 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.393659 | 0.405 |
R-HSA-72172 | mRNA Splicing | 0.396291 | 0.402 |
R-HSA-380287 | Centrosome maturation | 0.397357 | 0.401 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.397357 | 0.401 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.397357 | 0.401 |
R-HSA-5357801 | Programmed Cell Death | 0.398429 | 0.400 |
R-HSA-9824446 | Viral Infection Pathways | 0.399135 | 0.399 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.401032 | 0.397 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.401032 | 0.397 |
R-HSA-73894 | DNA Repair | 0.408286 | 0.389 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.408316 | 0.389 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.408316 | 0.389 |
R-HSA-8953897 | Cellular responses to stimuli | 0.416076 | 0.381 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.419079 | 0.378 |
R-HSA-68882 | Mitotic Anaphase | 0.421716 | 0.375 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.422623 | 0.374 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.423811 | 0.373 |
R-HSA-418990 | Adherens junctions interactions | 0.425902 | 0.371 |
R-HSA-390918 | Peroxisomal lipid metabolism | 0.429648 | 0.367 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.443444 | 0.353 |
R-HSA-68886 | M Phase | 0.445450 | 0.351 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.446595 | 0.350 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.446841 | 0.350 |
R-HSA-913531 | Interferon Signaling | 0.447046 | 0.350 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.453574 | 0.343 |
R-HSA-112310 | Neurotransmitter release cycle | 0.453574 | 0.343 |
R-HSA-73884 | Base Excision Repair | 0.453574 | 0.343 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.456910 | 0.340 |
R-HSA-1640170 | Cell Cycle | 0.457737 | 0.339 |
R-HSA-74752 | Signaling by Insulin receptor | 0.463521 | 0.334 |
R-HSA-391251 | Protein folding | 0.463521 | 0.334 |
R-HSA-9679506 | SARS-CoV Infections | 0.466520 | 0.331 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.481167 | 0.318 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.482881 | 0.316 |
R-HSA-9614085 | FOXO-mediated transcription | 0.489180 | 0.311 |
R-HSA-3214847 | HATs acetylate histones | 0.489180 | 0.311 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 0.489180 | 0.311 |
R-HSA-70171 | Glycolysis | 0.492300 | 0.308 |
R-HSA-421270 | Cell-cell junction organization | 0.492579 | 0.308 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.498485 | 0.302 |
R-HSA-1483255 | PI Metabolism | 0.498485 | 0.302 |
R-HSA-111885 | Opioid Signalling | 0.504595 | 0.297 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.513623 | 0.289 |
R-HSA-9734767 | Developmental Cell Lineages | 0.515615 | 0.288 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.516596 | 0.287 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.516596 | 0.287 |
R-HSA-211000 | Gene Silencing by RNA | 0.516596 | 0.287 |
R-HSA-9711123 | Cellular response to chemical stress | 0.525011 | 0.280 |
R-HSA-202403 | TCR signaling | 0.525407 | 0.280 |
R-HSA-194068 | Bile acid and bile salt metabolism | 0.525407 | 0.280 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.531192 | 0.275 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.531192 | 0.275 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.534059 | 0.272 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.536126 | 0.271 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.536908 | 0.270 |
R-HSA-446728 | Cell junction organization | 0.543438 | 0.265 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.545352 | 0.263 |
R-HSA-70326 | Glucose metabolism | 0.550897 | 0.259 |
R-HSA-5693538 | Homology Directed Repair | 0.553644 | 0.257 |
R-HSA-68875 | Mitotic Prophase | 0.559089 | 0.253 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.561787 | 0.250 |
R-HSA-162909 | Host Interactions of HIV factors | 0.569782 | 0.244 |
R-HSA-195721 | Signaling by WNT | 0.578803 | 0.237 |
R-HSA-114608 | Platelet degranulation | 0.580218 | 0.236 |
R-HSA-69481 | G2/M Checkpoints | 0.580218 | 0.236 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.582788 | 0.234 |
R-HSA-199991 | Membrane Trafficking | 0.584724 | 0.233 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.597882 | 0.223 |
R-HSA-8953854 | Metabolism of RNA | 0.601017 | 0.221 |
R-HSA-1500931 | Cell-Cell communication | 0.608909 | 0.215 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.617169 | 0.210 |
R-HSA-9664417 | Leishmania phagocytosis | 0.617169 | 0.210 |
R-HSA-9664407 | Parasite infection | 0.617169 | 0.210 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.619515 | 0.208 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.624164 | 0.205 |
R-HSA-166520 | Signaling by NTRKs | 0.637775 | 0.195 |
R-HSA-9758941 | Gastrulation | 0.639996 | 0.194 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.642203 | 0.192 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.644397 | 0.191 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.648744 | 0.188 |
R-HSA-9609507 | Protein localization | 0.648744 | 0.188 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.650898 | 0.186 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.653039 | 0.185 |
R-HSA-9610379 | HCMV Late Events | 0.657282 | 0.182 |
R-HSA-162587 | HIV Life Cycle | 0.657282 | 0.182 |
R-HSA-9711097 | Cellular response to starvation | 0.659385 | 0.181 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.659854 | 0.181 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.663551 | 0.178 |
R-HSA-5619102 | SLC transporter disorders | 0.677739 | 0.169 |
R-HSA-1643685 | Disease | 0.681584 | 0.166 |
R-HSA-72306 | tRNA processing | 0.685579 | 0.164 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.687510 | 0.163 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.689428 | 0.162 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.691335 | 0.160 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.691335 | 0.160 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.693231 | 0.159 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.695115 | 0.158 |
R-HSA-168255 | Influenza Infection | 0.702536 | 0.153 |
R-HSA-5617833 | Cilium Assembly | 0.722036 | 0.141 |
R-HSA-5663205 | Infectious disease | 0.726363 | 0.139 |
R-HSA-9609690 | HCMV Early Events | 0.732133 | 0.135 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.738662 | 0.132 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.743455 | 0.129 |
R-HSA-5653656 | Vesicle-mediated transport | 0.748688 | 0.126 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.758812 | 0.120 |
R-HSA-1266738 | Developmental Biology | 0.772625 | 0.112 |
R-HSA-162906 | HIV Infection | 0.780158 | 0.108 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.784197 | 0.106 |
R-HSA-6798695 | Neutrophil degranulation | 0.791387 | 0.102 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.795879 | 0.099 |
R-HSA-157118 | Signaling by NOTCH | 0.797138 | 0.098 |
R-HSA-112316 | Neuronal System | 0.801834 | 0.096 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.805736 | 0.094 |
R-HSA-9609646 | HCMV Infection | 0.809310 | 0.092 |
R-HSA-5688426 | Deubiquitination | 0.815122 | 0.089 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.816263 | 0.088 |
R-HSA-556833 | Metabolism of lipids | 0.822706 | 0.085 |
R-HSA-168249 | Innate Immune System | 0.839480 | 0.076 |
R-HSA-9658195 | Leishmania infection | 0.842632 | 0.074 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.842632 | 0.074 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.843605 | 0.074 |
R-HSA-1483257 | Phospholipid metabolism | 0.855725 | 0.068 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.878761 | 0.056 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.902087 | 0.045 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.906076 | 0.043 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.906883 | 0.042 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.917093 | 0.038 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.924034 | 0.034 |
R-HSA-418594 | G alpha (i) signalling events | 0.928637 | 0.032 |
R-HSA-8978868 | Fatty acid metabolism | 0.928637 | 0.032 |
R-HSA-168256 | Immune System | 0.934264 | 0.030 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.947162 | 0.024 |
R-HSA-388396 | GPCR downstream signalling | 0.957369 | 0.019 |
R-HSA-109582 | Hemostasis | 0.959571 | 0.018 |
R-HSA-1280218 | Adaptive Immune System | 0.961475 | 0.017 |
R-HSA-211859 | Biological oxidations | 0.965538 | 0.015 |
R-HSA-422475 | Axon guidance | 0.970000 | 0.013 |
R-HSA-372790 | Signaling by GPCR | 0.972668 | 0.012 |
R-HSA-9675108 | Nervous system development | 0.976251 | 0.010 |
R-HSA-597592 | Post-translational protein modification | 0.979918 | 0.009 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.981091 | 0.008 |
R-HSA-449147 | Signaling by Interleukins | 0.981911 | 0.008 |
R-HSA-382551 | Transport of small molecules | 0.998156 | 0.001 |
R-HSA-392499 | Metabolism of proteins | 0.998182 | 0.001 |
R-HSA-1430728 | Metabolism | 0.999301 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.781 | 0.355 | 1 | 0.858 |
KIS |
0.771 | 0.302 | 1 | 0.841 |
CLK2 |
0.770 | 0.327 | -3 | 0.703 |
HIPK4 |
0.769 | 0.301 | 1 | 0.861 |
SRPK1 |
0.763 | 0.197 | -3 | 0.724 |
DYRK4 |
0.763 | 0.369 | 1 | 0.811 |
DYRK2 |
0.759 | 0.315 | 1 | 0.847 |
COT |
0.755 | 0.075 | 2 | 0.420 |
HIPK2 |
0.752 | 0.275 | 1 | 0.804 |
CDK1 |
0.752 | 0.238 | 1 | 0.820 |
NDR2 |
0.749 | 0.081 | -3 | 0.778 |
PIM3 |
0.748 | 0.082 | -3 | 0.782 |
SRPK2 |
0.747 | 0.141 | -3 | 0.656 |
MTOR |
0.747 | 0.128 | 1 | 0.779 |
JNK2 |
0.746 | 0.273 | 1 | 0.813 |
CDK18 |
0.746 | 0.236 | 1 | 0.806 |
CDK19 |
0.746 | 0.227 | 1 | 0.819 |
NLK |
0.745 | 0.151 | 1 | 0.886 |
P38D |
0.745 | 0.291 | 1 | 0.793 |
SKMLCK |
0.744 | 0.120 | -2 | 0.801 |
PRKD1 |
0.744 | 0.125 | -3 | 0.782 |
CLK4 |
0.744 | 0.203 | -3 | 0.735 |
CLK1 |
0.743 | 0.202 | -3 | 0.718 |
CDK8 |
0.743 | 0.206 | 1 | 0.840 |
P38B |
0.743 | 0.269 | 1 | 0.804 |
CDK3 |
0.743 | 0.199 | 1 | 0.779 |
ATR |
0.741 | 0.107 | 1 | 0.836 |
CDK5 |
0.741 | 0.182 | 1 | 0.856 |
RSK2 |
0.740 | 0.070 | -3 | 0.744 |
CDKL1 |
0.740 | 0.086 | -3 | 0.781 |
ICK |
0.740 | 0.135 | -3 | 0.806 |
MOS |
0.740 | 0.055 | 1 | 0.755 |
PRKD2 |
0.740 | 0.114 | -3 | 0.733 |
CDK7 |
0.740 | 0.190 | 1 | 0.846 |
HIPK1 |
0.740 | 0.231 | 1 | 0.854 |
CDKL5 |
0.739 | 0.080 | -3 | 0.776 |
GCN2 |
0.739 | -0.023 | 2 | 0.374 |
CDK13 |
0.739 | 0.194 | 1 | 0.829 |
CDC7 |
0.739 | -0.026 | 1 | 0.729 |
JNK3 |
0.739 | 0.243 | 1 | 0.826 |
ERK5 |
0.738 | 0.093 | 1 | 0.818 |
ERK1 |
0.738 | 0.220 | 1 | 0.808 |
CDK17 |
0.737 | 0.218 | 1 | 0.767 |
PRPK |
0.737 | -0.028 | -1 | 0.731 |
CHAK2 |
0.737 | 0.038 | -1 | 0.791 |
PIM1 |
0.737 | 0.075 | -3 | 0.745 |
P38A |
0.737 | 0.242 | 1 | 0.849 |
P90RSK |
0.737 | 0.060 | -3 | 0.742 |
SRPK3 |
0.736 | 0.115 | -3 | 0.701 |
P38G |
0.736 | 0.229 | 1 | 0.765 |
NDR1 |
0.736 | 0.024 | -3 | 0.788 |
GRK1 |
0.736 | 0.039 | -2 | 0.762 |
DYRK1A |
0.735 | 0.197 | 1 | 0.867 |
CDK10 |
0.735 | 0.213 | 1 | 0.824 |
CAMK1B |
0.734 | 0.029 | -3 | 0.833 |
IKKB |
0.734 | -0.022 | -2 | 0.709 |
RIPK3 |
0.733 | -0.008 | 3 | 0.514 |
RAF1 |
0.733 | 0.025 | 1 | 0.744 |
CAMK2G |
0.733 | -0.050 | 2 | 0.382 |
DYRK1B |
0.733 | 0.235 | 1 | 0.825 |
CDK12 |
0.732 | 0.186 | 1 | 0.814 |
CDK9 |
0.732 | 0.186 | 1 | 0.833 |
AURC |
0.731 | 0.051 | -2 | 0.570 |
DSTYK |
0.731 | 0.002 | 2 | 0.430 |
TBK1 |
0.731 | -0.043 | 1 | 0.653 |
CDK14 |
0.731 | 0.207 | 1 | 0.831 |
ULK2 |
0.730 | -0.118 | 2 | 0.334 |
LATS2 |
0.730 | 0.022 | -5 | 0.701 |
WNK1 |
0.730 | -0.007 | -2 | 0.841 |
RSK3 |
0.730 | 0.033 | -3 | 0.740 |
IKKA |
0.730 | 0.004 | -2 | 0.705 |
HIPK3 |
0.729 | 0.204 | 1 | 0.846 |
NUAK2 |
0.729 | 0.033 | -3 | 0.799 |
CAMLCK |
0.729 | 0.026 | -2 | 0.771 |
PKCD |
0.729 | -0.002 | 2 | 0.331 |
PKN2 |
0.729 | 0.005 | -3 | 0.804 |
CDK2 |
0.729 | 0.131 | 1 | 0.848 |
MARK4 |
0.728 | 0.006 | 4 | 0.778 |
RSK4 |
0.728 | 0.070 | -3 | 0.694 |
PKN3 |
0.728 | -0.020 | -3 | 0.784 |
BMPR2 |
0.728 | -0.030 | -2 | 0.816 |
IKKE |
0.728 | -0.034 | 1 | 0.646 |
ERK2 |
0.728 | 0.185 | 1 | 0.839 |
MSK1 |
0.728 | 0.076 | -3 | 0.733 |
HUNK |
0.728 | -0.012 | 2 | 0.443 |
MST4 |
0.728 | -0.030 | 2 | 0.372 |
DYRK3 |
0.727 | 0.202 | 1 | 0.844 |
PAK1 |
0.727 | 0.006 | -2 | 0.720 |
DAPK2 |
0.727 | 0.040 | -3 | 0.836 |
CAMK2A |
0.727 | 0.061 | 2 | 0.418 |
PDHK4 |
0.727 | -0.133 | 1 | 0.781 |
CDK16 |
0.727 | 0.201 | 1 | 0.780 |
MASTL |
0.727 | -0.067 | -2 | 0.796 |
P70S6KB |
0.727 | 0.027 | -3 | 0.770 |
DNAPK |
0.726 | 0.128 | 1 | 0.768 |
NIK |
0.726 | -0.020 | -3 | 0.840 |
NIM1 |
0.726 | -0.052 | 3 | 0.500 |
SMG1 |
0.725 | 0.096 | 1 | 0.815 |
MLK2 |
0.725 | -0.027 | 2 | 0.353 |
CAMK2D |
0.725 | -0.003 | -3 | 0.813 |
NEK6 |
0.725 | -0.067 | -2 | 0.792 |
ULK1 |
0.725 | -0.101 | -3 | 0.790 |
JNK1 |
0.725 | 0.219 | 1 | 0.797 |
PKACG |
0.724 | 0.009 | -2 | 0.666 |
MLK1 |
0.724 | -0.099 | 2 | 0.364 |
PASK |
0.724 | 0.195 | -3 | 0.801 |
MLK3 |
0.723 | -0.038 | 2 | 0.323 |
PKACB |
0.723 | 0.059 | -2 | 0.593 |
LATS1 |
0.723 | 0.077 | -3 | 0.794 |
GRK5 |
0.722 | -0.086 | -3 | 0.813 |
TGFBR2 |
0.722 | -0.054 | -2 | 0.709 |
MNK1 |
0.722 | 0.024 | -2 | 0.719 |
ATM |
0.722 | 0.068 | 1 | 0.795 |
PRP4 |
0.722 | 0.161 | -3 | 0.705 |
MAPKAPK2 |
0.722 | 0.044 | -3 | 0.702 |
PAK3 |
0.721 | -0.027 | -2 | 0.718 |
PKCB |
0.721 | -0.016 | 2 | 0.312 |
CAMK2B |
0.721 | 0.014 | 2 | 0.380 |
FAM20C |
0.721 | -0.049 | 2 | 0.272 |
BMPR1B |
0.720 | 0.095 | 1 | 0.676 |
PDHK1 |
0.720 | -0.156 | 1 | 0.753 |
DLK |
0.720 | -0.004 | 1 | 0.745 |
MAPKAPK3 |
0.720 | 0.025 | -3 | 0.749 |
NEK7 |
0.720 | -0.134 | -3 | 0.805 |
MSK2 |
0.720 | 0.017 | -3 | 0.724 |
QSK |
0.719 | 0.016 | 4 | 0.754 |
DRAK1 |
0.719 | 0.119 | 1 | 0.700 |
GRK7 |
0.719 | 0.023 | 1 | 0.694 |
AMPKA1 |
0.719 | -0.046 | -3 | 0.809 |
PKCA |
0.718 | -0.023 | 2 | 0.305 |
MNK2 |
0.718 | -0.003 | -2 | 0.722 |
GSK3A |
0.717 | 0.099 | 4 | 0.549 |
ERK7 |
0.717 | 0.042 | 2 | 0.222 |
PRKX |
0.717 | 0.057 | -3 | 0.638 |
GRK6 |
0.717 | -0.044 | 1 | 0.722 |
RIPK1 |
0.717 | -0.093 | 1 | 0.732 |
PKCG |
0.717 | -0.035 | 2 | 0.330 |
IRE1 |
0.717 | -0.095 | 1 | 0.719 |
MARK3 |
0.716 | 0.047 | 4 | 0.726 |
WNK3 |
0.716 | -0.165 | 1 | 0.740 |
AMPKA2 |
0.716 | -0.026 | -3 | 0.779 |
ANKRD3 |
0.716 | -0.108 | 1 | 0.768 |
PKCZ |
0.716 | -0.024 | 2 | 0.329 |
PAK6 |
0.716 | -0.005 | -2 | 0.628 |
MYLK4 |
0.716 | 0.043 | -2 | 0.685 |
PRKD3 |
0.716 | 0.030 | -3 | 0.719 |
TSSK2 |
0.716 | -0.038 | -5 | 0.735 |
TGFBR1 |
0.716 | 0.035 | -2 | 0.733 |
YSK4 |
0.716 | 0.013 | 1 | 0.696 |
MAK |
0.716 | 0.181 | -2 | 0.729 |
CDK6 |
0.715 | 0.171 | 1 | 0.819 |
AURB |
0.715 | 0.006 | -2 | 0.568 |
PIM2 |
0.714 | 0.046 | -3 | 0.725 |
IRE2 |
0.714 | -0.094 | 2 | 0.300 |
TSSK1 |
0.714 | -0.032 | -3 | 0.818 |
ALK4 |
0.714 | -0.001 | -2 | 0.758 |
GRK4 |
0.714 | -0.085 | -2 | 0.757 |
GSK3B |
0.714 | 0.065 | 4 | 0.538 |
AKT2 |
0.713 | 0.043 | -3 | 0.668 |
NEK9 |
0.713 | -0.136 | 2 | 0.353 |
PAK2 |
0.713 | -0.039 | -2 | 0.705 |
CDK4 |
0.712 | 0.175 | 1 | 0.808 |
PKR |
0.712 | -0.038 | 1 | 0.756 |
VRK2 |
0.712 | -0.072 | 1 | 0.806 |
TLK2 |
0.712 | -0.004 | 1 | 0.756 |
PLK3 |
0.712 | -0.014 | 2 | 0.419 |
PKCH |
0.712 | -0.057 | 2 | 0.307 |
MEK1 |
0.712 | -0.039 | 2 | 0.415 |
NUAK1 |
0.712 | -0.026 | -3 | 0.754 |
PLK1 |
0.712 | -0.063 | -2 | 0.736 |
MLK4 |
0.711 | -0.097 | 2 | 0.309 |
PHKG1 |
0.711 | -0.063 | -3 | 0.780 |
CAMK4 |
0.711 | -0.057 | -3 | 0.783 |
CHAK1 |
0.710 | -0.091 | 2 | 0.343 |
BCKDK |
0.710 | -0.149 | -1 | 0.638 |
MELK |
0.710 | -0.056 | -3 | 0.768 |
SIK |
0.710 | -0.015 | -3 | 0.733 |
BRSK2 |
0.709 | -0.046 | -3 | 0.781 |
QIK |
0.709 | -0.065 | -3 | 0.806 |
SGK3 |
0.709 | 0.000 | -3 | 0.740 |
PLK4 |
0.709 | -0.094 | 2 | 0.310 |
BRSK1 |
0.709 | -0.037 | -3 | 0.752 |
MST3 |
0.708 | 0.017 | 2 | 0.408 |
TTBK2 |
0.708 | -0.176 | 2 | 0.309 |
DCAMKL1 |
0.708 | 0.003 | -3 | 0.737 |
PKG2 |
0.708 | -0.012 | -2 | 0.588 |
CAMK1G |
0.708 | 0.009 | -3 | 0.736 |
AURA |
0.707 | 0.004 | -2 | 0.537 |
MARK2 |
0.707 | -0.010 | 4 | 0.694 |
MPSK1 |
0.705 | 0.031 | 1 | 0.736 |
ACVR2B |
0.705 | 0.014 | -2 | 0.713 |
DCAMKL2 |
0.705 | -0.018 | -3 | 0.767 |
SNRK |
0.705 | -0.125 | 2 | 0.314 |
NEK2 |
0.704 | -0.096 | 2 | 0.344 |
CHK1 |
0.704 | -0.013 | -3 | 0.792 |
MARK1 |
0.703 | -0.013 | 4 | 0.733 |
ALK2 |
0.703 | 0.011 | -2 | 0.730 |
GAK |
0.702 | 0.118 | 1 | 0.769 |
MOK |
0.702 | 0.143 | 1 | 0.833 |
PKACA |
0.701 | 0.021 | -2 | 0.535 |
PKCE |
0.700 | -0.011 | 2 | 0.322 |
GRK2 |
0.700 | -0.036 | -2 | 0.643 |
ACVR2A |
0.700 | -0.028 | -2 | 0.699 |
NEK5 |
0.700 | -0.053 | 1 | 0.760 |
TAO3 |
0.700 | -0.022 | 1 | 0.737 |
STK33 |
0.699 | -0.051 | 2 | 0.316 |
P70S6K |
0.699 | -0.008 | -3 | 0.703 |
PKCT |
0.699 | -0.059 | 2 | 0.296 |
BMPR1A |
0.699 | 0.041 | 1 | 0.648 |
PERK |
0.699 | -0.099 | -2 | 0.747 |
PINK1 |
0.699 | -0.046 | 1 | 0.818 |
SMMLCK |
0.698 | 0.006 | -3 | 0.795 |
MEKK3 |
0.698 | -0.084 | 1 | 0.731 |
MEK5 |
0.698 | -0.150 | 2 | 0.380 |
PKCI |
0.698 | -0.048 | 2 | 0.313 |
WNK4 |
0.698 | -0.102 | -2 | 0.843 |
IRAK4 |
0.698 | -0.121 | 1 | 0.720 |
BUB1 |
0.698 | 0.135 | -5 | 0.705 |
GCK |
0.697 | 0.079 | 1 | 0.739 |
SLK |
0.697 | 0.070 | -2 | 0.705 |
NEK11 |
0.697 | -0.020 | 1 | 0.719 |
SSTK |
0.697 | -0.045 | 4 | 0.714 |
PAK4 |
0.696 | -0.040 | -2 | 0.588 |
AKT1 |
0.696 | -0.000 | -3 | 0.682 |
LKB1 |
0.696 | 0.036 | -3 | 0.786 |
MAPKAPK5 |
0.695 | -0.055 | -3 | 0.713 |
CK1E |
0.695 | -0.037 | -3 | 0.493 |
MEKK2 |
0.695 | -0.138 | 2 | 0.345 |
ZAK |
0.695 | -0.133 | 1 | 0.689 |
PDHK3_TYR |
0.695 | 0.160 | 4 | 0.835 |
DAPK3 |
0.694 | 0.017 | -3 | 0.757 |
MEKK1 |
0.694 | -0.165 | 1 | 0.729 |
PAK5 |
0.693 | -0.042 | -2 | 0.592 |
TLK1 |
0.693 | -0.072 | -2 | 0.755 |
MRCKA |
0.692 | 0.041 | -3 | 0.727 |
ROCK2 |
0.692 | 0.048 | -3 | 0.750 |
LOK |
0.692 | 0.010 | -2 | 0.736 |
SGK1 |
0.691 | 0.027 | -3 | 0.598 |
HPK1 |
0.691 | 0.042 | 1 | 0.725 |
PHKG2 |
0.691 | -0.088 | -3 | 0.767 |
PLK2 |
0.690 | -0.001 | -3 | 0.751 |
BRAF |
0.690 | -0.129 | -4 | 0.752 |
CAMKK1 |
0.690 | -0.048 | -2 | 0.703 |
DAPK1 |
0.690 | 0.019 | -3 | 0.748 |
HRI |
0.690 | -0.169 | -2 | 0.763 |
YANK3 |
0.690 | -0.036 | 2 | 0.232 |
TNIK |
0.689 | -0.009 | 3 | 0.627 |
CK1D |
0.689 | -0.020 | -3 | 0.445 |
PDK1 |
0.689 | -0.063 | 1 | 0.712 |
MRCKB |
0.689 | 0.022 | -3 | 0.715 |
AKT3 |
0.689 | 0.012 | -3 | 0.608 |
PDHK4_TYR |
0.689 | 0.174 | 2 | 0.457 |
CAMK1D |
0.688 | -0.009 | -3 | 0.653 |
MEKK6 |
0.688 | -0.056 | 1 | 0.727 |
CAMKK2 |
0.688 | -0.021 | -2 | 0.698 |
MST2 |
0.688 | -0.026 | 1 | 0.730 |
TAK1 |
0.688 | 0.014 | 1 | 0.746 |
HGK |
0.688 | -0.050 | 3 | 0.627 |
TTBK1 |
0.687 | -0.150 | 2 | 0.280 |
TAO2 |
0.687 | -0.088 | 2 | 0.362 |
MAP3K15 |
0.687 | -0.061 | 1 | 0.691 |
CK1G1 |
0.687 | -0.068 | -3 | 0.480 |
NEK8 |
0.686 | -0.129 | 2 | 0.360 |
KHS2 |
0.686 | 0.017 | 1 | 0.736 |
CK2A2 |
0.686 | -0.032 | 1 | 0.586 |
KHS1 |
0.686 | 0.009 | 1 | 0.713 |
MAP2K6_TYR |
0.686 | 0.152 | -1 | 0.729 |
MINK |
0.685 | -0.057 | 1 | 0.717 |
LIMK2_TYR |
0.685 | 0.070 | -3 | 0.845 |
CHK2 |
0.685 | 0.010 | -3 | 0.621 |
PKN1 |
0.685 | -0.048 | -3 | 0.716 |
EPHA6 |
0.685 | 0.086 | -1 | 0.722 |
TESK1_TYR |
0.685 | 0.038 | 3 | 0.608 |
LRRK2 |
0.684 | -0.063 | 2 | 0.380 |
CK1A2 |
0.684 | -0.042 | -3 | 0.446 |
NEK4 |
0.684 | -0.095 | 1 | 0.726 |
GRK3 |
0.683 | -0.055 | -2 | 0.602 |
DMPK1 |
0.683 | 0.051 | -3 | 0.726 |
PKMYT1_TYR |
0.683 | 0.003 | 3 | 0.599 |
MAP2K4_TYR |
0.682 | 0.067 | -1 | 0.731 |
EPHB4 |
0.682 | 0.112 | -1 | 0.704 |
MST1 |
0.682 | -0.015 | 1 | 0.715 |
CK2A1 |
0.682 | -0.013 | 1 | 0.571 |
EEF2K |
0.681 | -0.088 | 3 | 0.551 |
PBK |
0.681 | 0.021 | 1 | 0.699 |
SBK |
0.681 | 0.051 | -3 | 0.561 |
BMPR2_TYR |
0.680 | 0.069 | -1 | 0.723 |
PDHK1_TYR |
0.680 | 0.047 | -1 | 0.747 |
MAP2K7_TYR |
0.680 | -0.040 | 2 | 0.412 |
NEK1 |
0.679 | -0.074 | 1 | 0.722 |
TNK2 |
0.679 | 0.042 | 3 | 0.560 |
VRK1 |
0.679 | -0.102 | 2 | 0.382 |
CRIK |
0.679 | 0.048 | -3 | 0.684 |
EPHA4 |
0.679 | 0.107 | 2 | 0.452 |
IRAK1 |
0.679 | -0.215 | -1 | 0.629 |
ABL2 |
0.677 | 0.113 | -1 | 0.670 |
TXK |
0.677 | 0.117 | 1 | 0.716 |
OSR1 |
0.676 | -0.020 | 2 | 0.354 |
CAMK1A |
0.675 | -0.019 | -3 | 0.633 |
PINK1_TYR |
0.675 | -0.111 | 1 | 0.764 |
MEK2 |
0.674 | -0.138 | 2 | 0.362 |
ROCK1 |
0.674 | 0.018 | -3 | 0.724 |
ABL1 |
0.674 | 0.099 | -1 | 0.667 |
MST1R |
0.674 | -0.011 | 3 | 0.599 |
RET |
0.673 | -0.007 | 1 | 0.733 |
ITK |
0.673 | 0.105 | -1 | 0.685 |
YSK1 |
0.673 | -0.112 | 2 | 0.334 |
TYRO3 |
0.673 | -0.041 | 3 | 0.569 |
CSF1R |
0.672 | 0.008 | 3 | 0.583 |
SRMS |
0.672 | 0.096 | 1 | 0.723 |
YES1 |
0.672 | -0.003 | -1 | 0.748 |
PTK2B |
0.671 | 0.124 | -1 | 0.672 |
EPHB3 |
0.670 | 0.061 | -1 | 0.690 |
RIPK2 |
0.670 | -0.175 | 1 | 0.656 |
BLK |
0.670 | 0.046 | -1 | 0.720 |
DDR1 |
0.670 | -0.043 | 4 | 0.738 |
HASPIN |
0.670 | -0.036 | -1 | 0.603 |
LCK |
0.669 | 0.029 | -1 | 0.723 |
EPHB2 |
0.669 | 0.063 | -1 | 0.684 |
EPHB1 |
0.669 | 0.040 | 1 | 0.719 |
FGR |
0.668 | -0.020 | 1 | 0.750 |
TEK |
0.668 | 0.005 | 3 | 0.515 |
MERTK |
0.667 | 0.017 | 3 | 0.554 |
ROS1 |
0.667 | -0.143 | 3 | 0.529 |
HCK |
0.667 | -0.021 | -1 | 0.718 |
KIT |
0.667 | 0.026 | 3 | 0.586 |
BMX |
0.667 | 0.061 | -1 | 0.624 |
JAK2 |
0.667 | -0.094 | 1 | 0.720 |
LIMK1_TYR |
0.667 | -0.131 | 2 | 0.362 |
EPHA7 |
0.667 | 0.031 | 2 | 0.425 |
EPHA3 |
0.666 | 0.028 | 2 | 0.412 |
PTK2 |
0.666 | 0.100 | -1 | 0.656 |
FGFR2 |
0.666 | -0.034 | 3 | 0.550 |
MYO3B |
0.666 | -0.056 | 2 | 0.346 |
FYN |
0.665 | 0.053 | -1 | 0.713 |
TNK1 |
0.665 | -0.056 | 3 | 0.560 |
ASK1 |
0.665 | -0.078 | 1 | 0.672 |
TTK |
0.665 | -0.096 | -2 | 0.741 |
AXL |
0.665 | -0.035 | 3 | 0.555 |
PKG1 |
0.665 | -0.056 | -2 | 0.512 |
JAK3 |
0.664 | -0.051 | 1 | 0.714 |
FER |
0.664 | -0.060 | 1 | 0.750 |
TEC |
0.664 | 0.024 | -1 | 0.649 |
INSRR |
0.663 | -0.089 | 3 | 0.506 |
KDR |
0.663 | -0.049 | 3 | 0.538 |
DDR2 |
0.663 | 0.025 | 3 | 0.500 |
EPHA5 |
0.663 | 0.069 | 2 | 0.439 |
TYK2 |
0.662 | -0.207 | 1 | 0.718 |
NEK3 |
0.661 | -0.142 | 1 | 0.694 |
FLT3 |
0.661 | -0.069 | 3 | 0.579 |
MET |
0.661 | 0.001 | 3 | 0.594 |
MYO3A |
0.661 | -0.095 | 1 | 0.711 |
BIKE |
0.661 | -0.005 | 1 | 0.664 |
CK1A |
0.660 | -0.047 | -3 | 0.353 |
FRK |
0.660 | 0.003 | -1 | 0.722 |
FGFR1 |
0.660 | -0.088 | 3 | 0.523 |
NEK10_TYR |
0.660 | -0.056 | 1 | 0.650 |
FGFR3 |
0.659 | -0.019 | 3 | 0.530 |
EPHA1 |
0.659 | -0.007 | 3 | 0.579 |
LYN |
0.658 | -0.006 | 3 | 0.514 |
EPHA8 |
0.658 | 0.019 | -1 | 0.670 |
PDGFRB |
0.657 | -0.165 | 3 | 0.573 |
BTK |
0.656 | -0.054 | -1 | 0.670 |
TAO1 |
0.656 | -0.100 | 1 | 0.666 |
FLT1 |
0.655 | -0.005 | -1 | 0.671 |
WEE1_TYR |
0.655 | -0.075 | -1 | 0.640 |
JAK1 |
0.654 | -0.124 | 1 | 0.670 |
TNNI3K_TYR |
0.653 | -0.110 | 1 | 0.718 |
SRC |
0.653 | -0.015 | -1 | 0.708 |
EPHA2 |
0.653 | 0.050 | -1 | 0.629 |
YANK2 |
0.653 | -0.060 | 2 | 0.226 |
LTK |
0.652 | -0.122 | 3 | 0.507 |
ALPHAK3 |
0.652 | -0.064 | -1 | 0.637 |
ERBB2 |
0.651 | -0.089 | 1 | 0.669 |
PTK6 |
0.651 | -0.142 | -1 | 0.620 |
PDGFRA |
0.651 | -0.178 | 3 | 0.579 |
ALK |
0.650 | -0.157 | 3 | 0.490 |
MATK |
0.650 | -0.036 | -1 | 0.598 |
CSK |
0.650 | -0.031 | 2 | 0.411 |
NTRK1 |
0.649 | -0.130 | -1 | 0.664 |
FLT4 |
0.649 | -0.102 | 3 | 0.515 |
INSR |
0.649 | -0.138 | 3 | 0.504 |
AAK1 |
0.649 | 0.026 | 1 | 0.587 |
FGFR4 |
0.648 | -0.029 | -1 | 0.622 |
STLK3 |
0.646 | -0.145 | 1 | 0.675 |
SYK |
0.645 | 0.046 | -1 | 0.628 |
NTRK2 |
0.645 | -0.170 | 3 | 0.542 |
NTRK3 |
0.645 | -0.108 | -1 | 0.622 |
EGFR |
0.641 | -0.063 | 1 | 0.580 |
ERBB4 |
0.639 | -0.020 | 1 | 0.589 |
ZAP70 |
0.638 | 0.061 | -1 | 0.559 |
IGF1R |
0.637 | -0.128 | 3 | 0.458 |
MUSK |
0.633 | -0.113 | 1 | 0.579 |
FES |
0.630 | -0.076 | -1 | 0.602 |
CK1G3 |
0.627 | -0.075 | -3 | 0.305 |
CK1G2 |
0.625 | -0.050 | -3 | 0.396 |