Motif 358 (n=167)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0C4DFX4 | None | S2608 | ochoa | Snf2 related CREBBP activator protein | None |
A8K0Z3 | WASHC1 | S340 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
A8MWX3 | WASH4P | S353 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
C4AMC7 | WASH3P | S338 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
O15015 | ZNF646 | S1440 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
O15047 | SETD1A | S1169 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
O15211 | RGL2 | S617 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
O15231 | ZNF185 | S521 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
O15357 | INPPL1 | S149 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
O43166 | SIPA1L1 | S1645 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
O60292 | SIPA1L3 | S1158 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
O60292 | SIPA1L3 | S1438 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
O60307 | MAST3 | S1180 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
O94875 | SORBS2 | S152 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
O94875 | SORBS2 | S273 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
O94967 | WDR47 | S357 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
O95155 | UBE4B | S50 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
P04792 | HSPB1 | S156 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
P08631 | HCK | S43 | ochoa | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
P09874 | PARP1 | S383 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
P10588 | NR2F6 | S32 | ochoa | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}. |
P11137 | MAP2 | S1608 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
P15822 | HIVEP1 | S839 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
P15822 | HIVEP1 | S1141 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
P15884 | TCF4 | S188 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
P16471 | PRLR | S429 | ochoa | Prolactin receptor (PRL-R) | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}. |
P18887 | XRCC1 | S224 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
P22681 | CBL | S439 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
P26358 | DNMT1 | S141 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
P27448 | MARK3 | S563 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
P27816 | MAP4 | S825 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
P28324 | ELK4 | S213 | ochoa | ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}. |
P30291 | WEE1 | S137 | ochoa | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
P41212 | ETV6 | S182 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
P42694 | HELZ | S1738 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
P46013 | MKI67 | S563 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46821 | MAP1B | Y1762 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P47974 | ZFP36L2 | S259 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
P49796 | RGS3 | S728 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
P50570 | DNM2 | S759 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
P52735 | VAV2 | S583 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
P52799 | EFNB2 | S308 | ochoa | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}. |
P55199 | ELL | S401 | ochoa | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
P56524 | HDAC4 | S222 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
P78337 | PITX1 | S46 | ochoa | Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) | Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}. |
P78559 | MAP1A | S2425 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
P98172 | EFNB1 | S321 | ochoa | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
P98177 | FOXO4 | S30 | ochoa | Forkhead box protein O4 (Fork head domain transcription factor AFX1) | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}. |
Q00341 | HDLBP | S1245 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
Q01105 | SET | S28 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
Q04656 | ATP7A | S1430 | ochoa | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
Q04725 | TLE2 | S191 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
Q08495 | DMTN | S103 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
Q09019 | DMWD | S493 | ochoa | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}. |
Q10570 | CPSF1 | S751 | ochoa | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}. |
Q10570 | CPSF1 | S756 | ochoa | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}. |
Q12905 | ILF2 | S52 | ochoa | Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa) | Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:18458058, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:32433969, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
Q13207 | TBX2 | S384 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
Q13263 | TRIM28 | S596 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
Q13470 | TNK1 | S543 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
Q14004 | CDK13 | S662 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
Q14157 | UBAP2L | S460 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
Q14207 | NPAT | S1300 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
Q14739 | LBR | S97 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
Q15003 | NCAPH | S25 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
Q15772 | SPEG | S2391 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q16760 | DGKD | S666 | ochoa | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}. |
Q2M3G4 | SHROOM1 | S186 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
Q2NL68 | PROSER3 | S339 | ochoa | Proline and serine-rich protein 3 | None |
Q3KQU3 | MAP7D1 | S452 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
Q3YEC7 | RABL6 | T468 | ochoa | Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) | May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}. |
Q53TN4 | CYBRD1 | S232 | ochoa | Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3) | Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). {ECO:0000250|UniProtKB:Q925G2, ECO:0000269|PubMed:17068337, ECO:0000269|PubMed:30272000, ECO:0000305|PubMed:16510471}. |
Q562E7 | WDR81 | S1113 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
Q5JQS6 | GCSAML | S116 | ochoa | Germinal center-associated signaling and motility-like protein | None |
Q5T0W9 | FAM83B | S422 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
Q5T1M5 | FKBP15 | S320 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
Q5T200 | ZC3H13 | S376 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
Q5TC79 | ZBTB37 | S463 | ochoa | Zinc finger and BTB domain-containing protein 37 | May be involved in transcriptional regulation. |
Q5TC82 | RC3H1 | S460 | ochoa | Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25026078, PubMed:25504471). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). {ECO:0000250|UniProtKB:Q4VGL6, ECO:0000269|PubMed:25026078, ECO:0000269|PubMed:25504471, ECO:0000269|PubMed:25697406, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:31636267}. |
Q5THJ4 | VPS13D | S1744 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
Q5VT25 | CDC42BPA | S1664 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
Q68EM7 | ARHGAP17 | S674 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
Q6PJF5 | RHBDF2 | S323 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
Q6Q6R5 | CRIP3 | S94 | ochoa | Cysteine-rich protein 3 (CRP-3) (Chromosome 6 LIM domain only protein) (h6LIMo) | None |
Q6VEQ5 | WASH2P | S340 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
Q6ZNJ1 | NBEAL2 | S757 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
Q6ZQN7 | SLCO4C1 | S77 | ochoa | Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) | Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}. |
Q6ZRS2 | SRCAP | S2785 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
Q6ZU67 | BEND4 | S98 | ochoa | BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4) | None |
Q6ZUM4 | ARHGAP27 | S455 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
Q6ZV73 | FGD6 | S552 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
Q711Q0 | CEFIP | S1246 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
Q7KZI7 | MARK2 | S576 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
Q7Z3B3 | KANSL1 | S977 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
Q7Z434 | MAVS | S253 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
Q7Z591 | AKNA | S1133 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
Q7Z5R6 | APBB1IP | S529 | ochoa | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
Q86TP1 | PRUNE1 | S391 | ochoa | Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) | Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}. |
Q86UE8 | TLK2 | S115 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
Q86VP3 | PACS2 | S366 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
Q86VY4 | TSPYL5 | S178 | ochoa | Testis-specific Y-encoded-like protein 5 (TSPY-like protein 5) | Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. {ECO:0000269|PubMed:20079711, ECO:0000269|PubMed:21170034}. |
Q86Y01 | DTX1 | S187 | ochoa | E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}. |
Q8IYD8 | FANCM | S1794 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
Q8N1G0 | ZNF687 | S225 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
Q8N3F8 | MICALL1 | S513 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
Q8N3F8 | MICALL1 | S536 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
Q8N3V7 | SYNPO | S496 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8N8Z6 | DCBLD1 | S693 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
Q8NCF5 | NFATC2IP | S88 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
Q8TDM6 | DLG5 | S1019 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
Q8TEW8 | PARD3B | S344 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
Q8TF44 | C2CD4C | S72 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
Q8TF72 | SHROOM3 | S1019 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
Q8WUA7 | TBC1D22A | S143 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
Q8WVD3 | RNF138 | S137 | ochoa | E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) | E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). {ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. |
Q8WX93 | PALLD | S758 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
Q8WXE0 | CASKIN2 | S798 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
Q8WY91 | THAP4 | S237 | ochoa | Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) | Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}. |
Q92797 | SYMPK | S505 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
Q92918 | MAP4K1 | S405 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
Q92918 | MAP4K1 | S444 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
Q92994 | BRF1 | S564 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
Q96FS4 | SIPA1 | S53 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
Q96FS4 | SIPA1 | S770 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
Q96GY3 | LIN37 | S178 | ochoa | Protein lin-37 homolog (Antolefinin) | None |
Q96PE2 | ARHGEF17 | S507 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
Q96PK6 | RBM14 | S254 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
Q96T58 | SPEN | S2154 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
Q99567 | NUP88 | S168 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
Q99618 | CDCA3 | S29 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
Q99638 | RAD9A | S363 | psp | Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044). {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:31135337}. |
Q99700 | ATXN2 | S667 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
Q9BWN1 | PRR14 | S331 | ochoa | Proline-rich protein 14 | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}. |
Q9BXI6 | TBC1D10A | S407 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
Q9BYB0 | SHANK3 | S373 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
Q9BZL6 | PRKD2 | S198 | ochoa|psp | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
Q9C0B0 | UNK | S474 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
Q9C0C2 | TNKS1BP1 | S1450 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0J8 | WDR33 | S1217 | ochoa | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. |
Q9GZY8 | MFF | S93 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
Q9H3T3 | SEMA6B | S745 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
Q9H6K5 | PRR36 | S210 | ochoa | Proline-rich protein 36 | None |
Q9H7P9 | PLEKHG2 | S52 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
Q9HCD6 | TANC2 | S1556 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
Q9HDC5 | JPH1 | S573 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
Q9NQC1 | JADE2 | S117 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
Q9NRL2 | BAZ1A | S1279 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
Q9NSV4 | DIAPH3 | S24 | ochoa | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}. |
Q9NYF3 | FAM53C | S120 | ochoa | Protein FAM53C | None |
Q9NYF3 | FAM53C | S234 | ochoa | Protein FAM53C | None |
Q9P227 | ARHGAP23 | S332 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
Q9P242 | NYAP2 | S436 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
Q9P260 | RELCH | S54 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
Q9UJF2 | RASAL2 | S899 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
Q9UKE5 | TNIK | S572 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
Q9UKI8 | TLK1 | S741 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
Q9ULC8 | ZDHHC8 | S662 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
Q9ULH1 | ASAP1 | S777 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
Q9UPN3 | MACF1 | S7234 | ochoa|psp | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
Q9UQ35 | SRRM2 | S295 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9UQ35 | SRRM2 | S1318 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y2H5 | PLEKHA6 | S459 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
Q9Y2U8 | LEMD3 | S111 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
Q9Y4F5 | CEP170B | S671 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
Q9Y4U1 | MMACHC | S245 | ochoa | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}. |
Q9Y6G9 | DYNC1LI1 | S412 | ochoa | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}. |
Q96GD4 | AURKB | S43 | Sugiyama | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.001491 | 2.826 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.001502 | 2.823 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.001623 | 2.790 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.003027 | 2.519 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.004059 | 2.392 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.009530 | 2.021 |
R-HSA-4641265 | Repression of WNT target genes | 0.012556 | 1.901 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.014079 | 1.851 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.015461 | 1.811 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.016147 | 1.792 |
R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.030997 | 1.509 |
R-HSA-3359473 | Defective MMADHC causes MMAHCD | 0.030997 | 1.509 |
R-HSA-3359474 | Defective MMACHC causes MAHCC | 0.051129 | 1.291 |
R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.070846 | 1.150 |
R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.070846 | 1.150 |
R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.099659 | 1.001 |
R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.099659 | 1.001 |
R-HSA-3928664 | Ephrin signaling | 0.024740 | 1.607 |
R-HSA-912631 | Regulation of signaling by CBL | 0.026756 | 1.573 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.136700 | 0.864 |
R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.145721 | 0.836 |
R-HSA-1170546 | Prolactin receptor signaling | 0.172226 | 0.764 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.180877 | 0.743 |
R-HSA-72187 | mRNA 3'-end processing | 0.025880 | 1.587 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.189439 | 0.723 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.032933 | 1.482 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.206297 | 0.686 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.230933 | 0.637 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.292974 | 0.533 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.292974 | 0.533 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.300371 | 0.522 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.300371 | 0.522 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.307691 | 0.512 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.314934 | 0.502 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.322103 | 0.492 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.322103 | 0.492 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.336216 | 0.473 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.336216 | 0.473 |
R-HSA-390522 | Striated Muscle Contraction | 0.343163 | 0.464 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.343163 | 0.464 |
R-HSA-5696400 | Dual Incision in GG-NER | 0.350038 | 0.456 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.356841 | 0.448 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.259268 | 0.586 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.259268 | 0.586 |
R-HSA-182971 | EGFR downregulation | 0.322103 | 0.492 |
R-HSA-354192 | Integrin signaling | 0.336216 | 0.473 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.230933 | 0.637 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.178898 | 0.747 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.104144 | 0.982 |
R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.099659 | 1.001 |
R-HSA-190873 | Gap junction degradation | 0.118373 | 0.927 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.246933 | 0.607 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.207004 | 0.684 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.093130 | 1.031 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.110837 | 0.955 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.110837 | 0.955 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.110837 | 0.955 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.251527 | 0.599 |
R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.070846 | 1.150 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.078628 | 1.104 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.094328 | 1.025 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.336216 | 0.473 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.180877 | 0.743 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.285500 | 0.544 |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.136700 | 0.864 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.254809 | 0.594 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.255397 | 0.593 |
R-HSA-5673000 | RAF activation | 0.350038 | 0.456 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.091119 | 1.040 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.094328 | 1.025 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.324871 | 0.488 |
R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.118373 | 0.927 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.020697 | 1.684 |
R-HSA-6802949 | Signaling by RAS mutants | 0.110837 | 0.955 |
R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.246933 | 0.607 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.197912 | 0.704 |
R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.246933 | 0.607 |
R-HSA-9759218 | Cobalamin (Cbl) metabolism | 0.292974 | 0.533 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.370236 | 0.432 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.214595 | 0.668 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.307691 | 0.512 |
R-HSA-1538133 | G0 and Early G1 | 0.329196 | 0.483 |
R-HSA-69478 | G2/M DNA replication checkpoint | 0.090155 | 1.045 |
R-HSA-196025 | Formation of annular gap junctions | 0.109065 | 0.962 |
R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 0.127584 | 0.894 |
R-HSA-192814 | vRNA Synthesis | 0.136700 | 0.864 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.145721 | 0.836 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.036797 | 1.434 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.246933 | 0.607 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.254809 | 0.594 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.270315 | 0.568 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.363573 | 0.439 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.363573 | 0.439 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.370236 | 0.432 |
R-HSA-156711 | Polo-like kinase mediated events | 0.024740 | 1.607 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.314934 | 0.502 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.322103 | 0.492 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.363573 | 0.439 |
R-HSA-177929 | Signaling by EGFR | 0.145796 | 0.836 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.263140 | 0.580 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.154648 | 0.811 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.125997 | 0.900 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.033183 | 1.479 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.078628 | 1.104 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.285500 | 0.544 |
R-HSA-6807004 | Negative regulation of MET activity | 0.230933 | 0.637 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.163483 | 0.787 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.343163 | 0.464 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.343163 | 0.464 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.363573 | 0.439 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.052843 | 1.277 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.246933 | 0.607 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.300371 | 0.522 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.307691 | 0.512 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.350038 | 0.456 |
R-HSA-2424491 | DAP12 signaling | 0.314934 | 0.502 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.172226 | 0.764 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.336216 | 0.473 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.091119 | 1.040 |
R-HSA-6794361 | Neurexins and neuroligins | 0.025880 | 1.587 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.149409 | 0.826 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.197751 | 0.704 |
R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.118373 | 0.927 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.167729 | 0.775 |
R-HSA-5334118 | DNA methylation | 0.307691 | 0.512 |
R-HSA-180746 | Nuclear import of Rev protein | 0.350038 | 0.456 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.059386 | 1.226 |
R-HSA-114604 | GPVI-mediated activation cascade | 0.363573 | 0.439 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.180877 | 0.743 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.355962 | 0.449 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.285500 | 0.544 |
R-HSA-5693538 | Homology Directed Repair | 0.162358 | 0.790 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.372090 | 0.429 |
R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.061039 | 1.214 |
R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.070846 | 1.150 |
R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.109065 | 0.962 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.118373 | 0.927 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.154648 | 0.811 |
R-HSA-9706369 | Negative regulation of FLT3 | 0.189439 | 0.723 |
R-HSA-429947 | Deadenylation of mRNA | 0.270315 | 0.568 |
R-HSA-9839394 | TGFBR3 expression | 0.277947 | 0.556 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.213001 | 0.672 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.350038 | 0.456 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.363573 | 0.439 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.228360 | 0.641 |
R-HSA-9682385 | FLT3 signaling in disease | 0.075596 | 1.122 |
R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.136700 | 0.864 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.021683 | 1.664 |
R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 0.277947 | 0.556 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.332517 | 0.478 |
R-HSA-68886 | M Phase | 0.133313 | 0.875 |
R-HSA-164944 | Nef and signal transduction | 0.090155 | 1.045 |
R-HSA-8964011 | HDL clearance | 0.090155 | 1.045 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.376828 | 0.424 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.362834 | 0.440 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.180877 | 0.743 |
R-HSA-445144 | Signal transduction by L1 | 0.230933 | 0.637 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.075412 | 1.123 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.072603 | 1.139 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.214595 | 0.668 |
R-HSA-912526 | Interleukin receptor SHC signaling | 0.262602 | 0.581 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.322103 | 0.492 |
R-HSA-5683057 | MAPK family signaling cascades | 0.341862 | 0.466 |
R-HSA-73894 | DNA Repair | 0.368796 | 0.433 |
R-HSA-68882 | Mitotic Anaphase | 0.236648 | 0.626 |
R-HSA-9823730 | Formation of definitive endoderm | 0.230933 | 0.637 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.238895 | 0.622 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.356841 | 0.448 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.313362 | 0.504 |
R-HSA-68875 | Mitotic Prophase | 0.167428 | 0.776 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.063868 | 1.195 |
R-HSA-193648 | NRAGE signals death through JNK | 0.030482 | 1.516 |
R-HSA-392517 | Rap1 signalling | 0.222807 | 0.652 |
R-HSA-525793 | Myogenesis | 0.285500 | 0.544 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.356841 | 0.448 |
R-HSA-3371511 | HSF1 activation | 0.363573 | 0.439 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.374075 | 0.427 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.166029 | 0.780 |
R-HSA-3214847 | HATs acetylate histones | 0.321040 | 0.493 |
R-HSA-73884 | Base Excision Repair | 0.278628 | 0.555 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.238975 | 0.622 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.238975 | 0.622 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.334145 | 0.476 |
R-HSA-1433559 | Regulation of KIT signaling | 0.172226 | 0.764 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.189439 | 0.723 |
R-HSA-9833482 | PKR-mediated signaling | 0.066290 | 1.179 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.236069 | 0.627 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.267646 | 0.572 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.376828 | 0.424 |
R-HSA-1640170 | Cell Cycle | 0.237364 | 0.625 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.175162 | 0.757 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.216832 | 0.664 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.263140 | 0.580 |
R-HSA-8963896 | HDL assembly | 0.172226 | 0.764 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.121078 | 0.917 |
R-HSA-879518 | Organic anion transport by SLCO transporters | 0.262602 | 0.581 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.336216 | 0.473 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.130660 | 0.884 |
R-HSA-5223345 | Miscellaneous transport and binding events | 0.343163 | 0.464 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.343163 | 0.464 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.350038 | 0.456 |
R-HSA-9833110 | RSV-host interactions | 0.343939 | 0.464 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.057350 | 1.241 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.205360 | 0.687 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.118373 | 0.927 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.197751 | 0.704 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.376828 | 0.424 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.130660 | 0.884 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 0.285500 | 0.544 |
R-HSA-9607240 | FLT3 Signaling | 0.091119 | 1.040 |
R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.254809 | 0.594 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.336216 | 0.473 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.108496 | 0.965 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.246933 | 0.607 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.336216 | 0.473 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.329196 | 0.483 |
R-HSA-9733709 | Cardiogenesis | 0.336216 | 0.473 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.254809 | 0.594 |
R-HSA-69205 | G1/S-Specific Transcription | 0.363573 | 0.439 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.370236 | 0.432 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.062794 | 1.202 |
R-HSA-191273 | Cholesterol biosynthesis | 0.228360 | 0.641 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.075596 | 1.122 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.329196 | 0.483 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.167729 | 0.775 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.054444 | 1.264 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.206297 | 0.686 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.206297 | 0.686 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.262602 | 0.581 |
R-HSA-8963898 | Plasma lipoprotein assembly | 0.270315 | 0.568 |
R-HSA-1059683 | Interleukin-6 signaling | 0.163483 | 0.787 |
R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.262602 | 0.581 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.332517 | 0.478 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.259198 | 0.586 |
R-HSA-8853659 | RET signaling | 0.363573 | 0.439 |
R-HSA-9006936 | Signaling by TGFB family members | 0.287474 | 0.541 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.313362 | 0.504 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.229940 | 0.638 |
R-HSA-982772 | Growth hormone receptor signaling | 0.262602 | 0.581 |
R-HSA-6783589 | Interleukin-6 family signaling | 0.270315 | 0.568 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.329196 | 0.483 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.282497 | 0.549 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.290231 | 0.537 |
R-HSA-1483255 | PI Metabolism | 0.332517 | 0.478 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.110176 | 0.958 |
R-HSA-73887 | Death Receptor Signaling | 0.270469 | 0.568 |
R-HSA-162582 | Signal Transduction | 0.377094 | 0.424 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.383353 | 0.416 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.383353 | 0.416 |
R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.383353 | 0.416 |
R-HSA-201556 | Signaling by ALK | 0.383353 | 0.416 |
R-HSA-8964043 | Plasma lipoprotein clearance | 0.383353 | 0.416 |
R-HSA-68877 | Mitotic Prometaphase | 0.384359 | 0.415 |
R-HSA-6798695 | Neutrophil degranulation | 0.386980 | 0.412 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.389809 | 0.409 |
R-HSA-3371568 | Attenuation phase | 0.389809 | 0.409 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.389809 | 0.409 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.389809 | 0.409 |
R-HSA-9646399 | Aggrephagy | 0.389809 | 0.409 |
R-HSA-167169 | HIV Transcription Elongation | 0.389809 | 0.409 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.389809 | 0.409 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.389809 | 0.409 |
R-HSA-451927 | Interleukin-2 family signaling | 0.389809 | 0.409 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.392628 | 0.406 |
R-HSA-9609690 | HCMV Early Events | 0.392828 | 0.406 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.396198 | 0.402 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.396198 | 0.402 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.396198 | 0.402 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.396198 | 0.402 |
R-HSA-9694548 | Maturation of spike protein | 0.396198 | 0.402 |
R-HSA-373760 | L1CAM interactions | 0.396310 | 0.402 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.402521 | 0.395 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.402521 | 0.395 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.407293 | 0.390 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.407543 | 0.390 |
R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.408778 | 0.389 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.414561 | 0.382 |
R-HSA-3371556 | Cellular response to heat stress | 0.414561 | 0.382 |
R-HSA-9710421 | Defective pyroptosis | 0.414969 | 0.382 |
R-HSA-8854214 | TBC/RABGAPs | 0.414969 | 0.382 |
R-HSA-5654743 | Signaling by FGFR4 | 0.414969 | 0.382 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.414969 | 0.382 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.414969 | 0.382 |
R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.421097 | 0.376 |
R-HSA-2172127 | DAP12 interactions | 0.421097 | 0.376 |
R-HSA-190828 | Gap junction trafficking | 0.421097 | 0.376 |
R-HSA-2132295 | MHC class II antigen presentation | 0.421786 | 0.375 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.421786 | 0.375 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.423970 | 0.373 |
R-HSA-162909 | Host Interactions of HIV factors | 0.425381 | 0.371 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.427160 | 0.369 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.427160 | 0.369 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.427160 | 0.369 |
R-HSA-5654741 | Signaling by FGFR3 | 0.427160 | 0.369 |
R-HSA-74160 | Gene expression (Transcription) | 0.431530 | 0.365 |
R-HSA-194138 | Signaling by VEGF | 0.432537 | 0.364 |
R-HSA-69206 | G1/S Transition | 0.432537 | 0.364 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.433160 | 0.363 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.433160 | 0.363 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.433160 | 0.363 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.433160 | 0.363 |
R-HSA-9675135 | Diseases of DNA repair | 0.433160 | 0.363 |
R-HSA-75153 | Apoptotic execution phase | 0.433160 | 0.363 |
R-HSA-437239 | Recycling pathway of L1 | 0.439098 | 0.357 |
R-HSA-69481 | G2/M Checkpoints | 0.439645 | 0.357 |
R-HSA-9031628 | NGF-stimulated transcription | 0.444974 | 0.352 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.450789 | 0.346 |
R-HSA-9766229 | Degradation of CDH1 | 0.450789 | 0.346 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.456543 | 0.341 |
R-HSA-9748787 | Azathioprine ADME | 0.456543 | 0.341 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.462238 | 0.335 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.467873 | 0.330 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.467873 | 0.330 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.473449 | 0.325 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.473449 | 0.325 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.473449 | 0.325 |
R-HSA-72649 | Translation initiation complex formation | 0.478967 | 0.320 |
R-HSA-162906 | HIV Infection | 0.480774 | 0.318 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.481243 | 0.318 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.484428 | 0.315 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.486105 | 0.313 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.489832 | 0.310 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.489832 | 0.310 |
R-HSA-5654736 | Signaling by FGFR1 | 0.489832 | 0.310 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.489832 | 0.310 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.489832 | 0.310 |
R-HSA-9664407 | Parasite infection | 0.491347 | 0.309 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.491347 | 0.309 |
R-HSA-9664417 | Leishmania phagocytosis | 0.491347 | 0.309 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.495179 | 0.305 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.495179 | 0.305 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.499248 | 0.302 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.500471 | 0.301 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.501326 | 0.300 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.501326 | 0.300 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.504625 | 0.297 |
R-HSA-191859 | snRNP Assembly | 0.505707 | 0.296 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.505707 | 0.296 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.505707 | 0.296 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.510890 | 0.292 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.510890 | 0.292 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.510890 | 0.292 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.510890 | 0.292 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.510890 | 0.292 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.510890 | 0.292 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.514437 | 0.289 |
R-HSA-157118 | Signaling by NOTCH | 0.514818 | 0.288 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.516018 | 0.287 |
R-HSA-69242 | S Phase | 0.520907 | 0.283 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.526114 | 0.279 |
R-HSA-8848021 | Signaling by PTK6 | 0.526114 | 0.279 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.526114 | 0.279 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.536552 | 0.270 |
R-HSA-4839726 | Chromatin organization | 0.537686 | 0.269 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.539971 | 0.268 |
R-HSA-9609646 | HCMV Infection | 0.540189 | 0.267 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.540867 | 0.267 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.543097 | 0.265 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.545683 | 0.263 |
R-HSA-8953854 | Metabolism of RNA | 0.545752 | 0.263 |
R-HSA-162587 | HIV Life Cycle | 0.549306 | 0.260 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.550448 | 0.259 |
R-HSA-167172 | Transcription of the HIV genome | 0.550448 | 0.259 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.550448 | 0.259 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.558509 | 0.253 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.559830 | 0.252 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.564448 | 0.248 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.564448 | 0.248 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.564448 | 0.248 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.564448 | 0.248 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.564448 | 0.248 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.569017 | 0.245 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.569017 | 0.245 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.569017 | 0.245 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.570571 | 0.244 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.573539 | 0.241 |
R-HSA-4086398 | Ca2+ pathway | 0.573539 | 0.241 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.578014 | 0.238 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.579870 | 0.237 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.582442 | 0.235 |
R-HSA-917937 | Iron uptake and transport | 0.582442 | 0.235 |
R-HSA-72306 | tRNA processing | 0.591106 | 0.228 |
R-HSA-9694635 | Translation of Structural Proteins | 0.591160 | 0.228 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.595451 | 0.225 |
R-HSA-9955298 | SLC-mediated transport of organic anions | 0.595451 | 0.225 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.599682 | 0.222 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.599682 | 0.222 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.599698 | 0.222 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.602511 | 0.220 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.603900 | 0.219 |
R-HSA-5654738 | Signaling by FGFR2 | 0.603900 | 0.219 |
R-HSA-6806834 | Signaling by MET | 0.603900 | 0.219 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.608058 | 0.216 |
R-HSA-9658195 | Leishmania infection | 0.613787 | 0.212 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.613787 | 0.212 |
R-HSA-913531 | Interferon Signaling | 0.614839 | 0.211 |
R-HSA-168255 | Influenza Infection | 0.616429 | 0.210 |
R-HSA-2559583 | Cellular Senescence | 0.619168 | 0.208 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.624260 | 0.205 |
R-HSA-69275 | G2/M Transition | 0.635287 | 0.197 |
R-HSA-9663891 | Selective autophagy | 0.639797 | 0.194 |
R-HSA-9645723 | Diseases of programmed cell death | 0.639797 | 0.194 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.640540 | 0.193 |
R-HSA-983712 | Ion channel transport | 0.643145 | 0.192 |
R-HSA-195721 | Signaling by WNT | 0.650667 | 0.187 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.657577 | 0.182 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.658323 | 0.182 |
R-HSA-2029481 | FCGR activation | 0.661913 | 0.179 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.668980 | 0.175 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.672459 | 0.172 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.675901 | 0.170 |
R-HSA-190236 | Signaling by FGFR | 0.682678 | 0.166 |
R-HSA-9614085 | FOXO-mediated transcription | 0.686013 | 0.164 |
R-HSA-70171 | Glycolysis | 0.689314 | 0.162 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.692580 | 0.160 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.695812 | 0.158 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.702175 | 0.154 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.711472 | 0.148 |
R-HSA-422475 | Axon guidance | 0.711590 | 0.148 |
R-HSA-211000 | Gene Silencing by RNA | 0.714506 | 0.146 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.717509 | 0.144 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.717509 | 0.144 |
R-HSA-6803157 | Antimicrobial peptides | 0.726330 | 0.139 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.729209 | 0.137 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.734877 | 0.134 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.735539 | 0.133 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.743159 | 0.129 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.745862 | 0.127 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.745862 | 0.127 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.746015 | 0.127 |
R-HSA-9007101 | Rab regulation of trafficking | 0.748537 | 0.126 |
R-HSA-70326 | Glucose metabolism | 0.748537 | 0.126 |
R-HSA-2980736 | Peptide hormone metabolism | 0.748537 | 0.126 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.751184 | 0.124 |
R-HSA-9675108 | Nervous system development | 0.761799 | 0.118 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.773793 | 0.111 |
R-HSA-114608 | Platelet degranulation | 0.776175 | 0.110 |
R-HSA-212436 | Generic Transcription Pathway | 0.778145 | 0.109 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.778533 | 0.109 |
R-HSA-5688426 | Deubiquitination | 0.785792 | 0.105 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.789955 | 0.102 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.792168 | 0.101 |
R-HSA-416476 | G alpha (q) signalling events | 0.800588 | 0.097 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.800791 | 0.096 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.811072 | 0.091 |
R-HSA-1632852 | Macroautophagy | 0.811072 | 0.091 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.824584 | 0.084 |
R-HSA-166520 | Signaling by NTRKs | 0.826435 | 0.083 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.826435 | 0.083 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.827500 | 0.082 |
R-HSA-9758941 | Gastrulation | 0.828266 | 0.082 |
R-HSA-9612973 | Autophagy | 0.840555 | 0.075 |
R-HSA-9610379 | HCMV Late Events | 0.842238 | 0.075 |
R-HSA-1483257 | Phospholipid metabolism | 0.844868 | 0.073 |
R-HSA-168249 | Innate Immune System | 0.846602 | 0.072 |
R-HSA-109581 | Apoptosis | 0.850390 | 0.070 |
R-HSA-9824446 | Viral Infection Pathways | 0.857649 | 0.067 |
R-HSA-5619102 | SLC transporter disorders | 0.858124 | 0.066 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.866882 | 0.062 |
R-HSA-5689880 | Ub-specific processing proteases | 0.868288 | 0.061 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.868288 | 0.061 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.868288 | 0.061 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.871057 | 0.060 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.871057 | 0.060 |
R-HSA-8957322 | Metabolism of steroids | 0.878050 | 0.056 |
R-HSA-112316 | Neuronal System | 0.889757 | 0.051 |
R-HSA-5617833 | Cilium Assembly | 0.890058 | 0.051 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.891221 | 0.050 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.894169 | 0.049 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.894636 | 0.048 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.896854 | 0.047 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.901151 | 0.045 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.901151 | 0.045 |
R-HSA-428157 | Sphingolipid metabolism | 0.902197 | 0.045 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.903233 | 0.044 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.904257 | 0.044 |
R-HSA-72172 | mRNA Splicing | 0.906273 | 0.043 |
R-HSA-382551 | Transport of small molecules | 0.906425 | 0.043 |
R-HSA-5357801 | Programmed Cell Death | 0.907265 | 0.042 |
R-HSA-397014 | Muscle contraction | 0.913925 | 0.039 |
R-HSA-9748784 | Drug ADME | 0.919253 | 0.037 |
R-HSA-418990 | Adherens junctions interactions | 0.919253 | 0.037 |
R-HSA-388396 | GPCR downstream signalling | 0.923597 | 0.035 |
R-HSA-199991 | Membrane Trafficking | 0.923649 | 0.034 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.925851 | 0.033 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.926988 | 0.033 |
R-HSA-109582 | Hemostasis | 0.928404 | 0.032 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.928946 | 0.032 |
R-HSA-8939211 | ESR-mediated signaling | 0.934056 | 0.030 |
R-HSA-1643685 | Disease | 0.937388 | 0.028 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.940729 | 0.027 |
R-HSA-9679506 | SARS-CoV Infections | 0.943145 | 0.025 |
R-HSA-421270 | Cell-cell junction organization | 0.943206 | 0.025 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.946159 | 0.024 |
R-HSA-9711123 | Cellular response to chemical stress | 0.952636 | 0.021 |
R-HSA-5663205 | Infectious disease | 0.953513 | 0.021 |
R-HSA-372790 | Signaling by GPCR | 0.956096 | 0.019 |
R-HSA-446728 | Cell junction organization | 0.957438 | 0.019 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.964516 | 0.016 |
R-HSA-2262752 | Cellular responses to stress | 0.964739 | 0.016 |
R-HSA-449147 | Signaling by Interleukins | 0.967524 | 0.014 |
R-HSA-1280218 | Adaptive Immune System | 0.970767 | 0.013 |
R-HSA-1500931 | Cell-Cell communication | 0.971664 | 0.012 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.972853 | 0.012 |
R-HSA-5653656 | Vesicle-mediated transport | 0.976449 | 0.010 |
R-HSA-1266738 | Developmental Biology | 0.978035 | 0.010 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.978561 | 0.009 |
R-HSA-168256 | Immune System | 0.980940 | 0.008 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.982891 | 0.007 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.983074 | 0.007 |
R-HSA-8953897 | Cellular responses to stimuli | 0.985300 | 0.006 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.987341 | 0.006 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.988261 | 0.005 |
R-HSA-418594 | G alpha (i) signalling events | 0.989460 | 0.005 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.991035 | 0.004 |
R-HSA-5668914 | Diseases of metabolism | 0.991506 | 0.004 |
R-HSA-72766 | Translation | 0.991687 | 0.004 |
R-HSA-597592 | Post-translational protein modification | 0.993633 | 0.003 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.993723 | 0.003 |
R-HSA-556833 | Metabolism of lipids | 0.999712 | 0.000 |
R-HSA-392499 | Metabolism of proteins | 0.999814 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.804 | 0.274 | 1 | 0.821 |
COT |
0.801 | 0.184 | 2 | 0.338 |
NDR2 |
0.792 | 0.092 | -3 | 0.862 |
CLK2 |
0.792 | 0.277 | -3 | 0.758 |
SKMLCK |
0.791 | 0.208 | -2 | 0.857 |
HIPK4 |
0.790 | 0.140 | 1 | 0.816 |
RSK2 |
0.789 | 0.123 | -3 | 0.797 |
PIM3 |
0.788 | 0.115 | -3 | 0.849 |
DYRK4 |
0.788 | 0.247 | 1 | 0.686 |
CDKL5 |
0.785 | 0.130 | -3 | 0.813 |
SRPK1 |
0.785 | 0.123 | -3 | 0.764 |
AURC |
0.785 | 0.137 | -2 | 0.697 |
DYRK2 |
0.784 | 0.183 | 1 | 0.753 |
ERK5 |
0.783 | 0.150 | 1 | 0.915 |
NDR1 |
0.783 | 0.076 | -3 | 0.855 |
P90RSK |
0.783 | 0.095 | -3 | 0.795 |
RSK4 |
0.780 | 0.131 | -3 | 0.766 |
RSK3 |
0.780 | 0.086 | -3 | 0.787 |
MOS |
0.780 | 0.086 | 1 | 0.799 |
PRKD1 |
0.780 | 0.068 | -3 | 0.850 |
CAMK1B |
0.779 | 0.090 | -3 | 0.867 |
CDKL1 |
0.779 | 0.095 | -3 | 0.815 |
MTOR |
0.779 | 0.104 | 1 | 0.801 |
PRKD2 |
0.779 | 0.084 | -3 | 0.799 |
LATS2 |
0.779 | 0.046 | -5 | 0.711 |
CAMK2A |
0.778 | 0.115 | 2 | 0.352 |
RIPK3 |
0.778 | 0.106 | 3 | 0.740 |
MSK1 |
0.778 | 0.145 | -3 | 0.777 |
ICK |
0.778 | 0.124 | -3 | 0.853 |
PAK1 |
0.778 | 0.091 | -2 | 0.794 |
KIS |
0.778 | 0.085 | 1 | 0.747 |
CDC7 |
0.777 | -0.008 | 1 | 0.756 |
PIM1 |
0.776 | 0.095 | -3 | 0.800 |
GCN2 |
0.776 | -0.073 | 2 | 0.271 |
PKACG |
0.776 | 0.078 | -2 | 0.754 |
CLK4 |
0.775 | 0.167 | -3 | 0.783 |
HUNK |
0.775 | 0.092 | 2 | 0.349 |
NLK |
0.775 | 0.042 | 1 | 0.845 |
CAMK2G |
0.775 | -0.009 | 2 | 0.314 |
PKACB |
0.775 | 0.123 | -2 | 0.704 |
CAMLCK |
0.774 | 0.105 | -2 | 0.845 |
FAM20C |
0.773 | -0.003 | 2 | 0.234 |
PRPK |
0.773 | -0.055 | -1 | 0.791 |
CAMK2B |
0.773 | 0.065 | 2 | 0.323 |
CAMK2D |
0.772 | 0.035 | -3 | 0.862 |
RAF1 |
0.772 | 0.068 | 1 | 0.789 |
GRK1 |
0.772 | 0.055 | -2 | 0.766 |
SRPK2 |
0.772 | 0.081 | -3 | 0.692 |
WNK1 |
0.772 | 0.045 | -2 | 0.845 |
PAK3 |
0.771 | 0.058 | -2 | 0.779 |
P70S6KB |
0.771 | 0.070 | -3 | 0.815 |
IKKB |
0.771 | -0.003 | -2 | 0.685 |
TBK1 |
0.771 | -0.040 | 1 | 0.702 |
PKN2 |
0.771 | 0.060 | -3 | 0.853 |
CLK1 |
0.771 | 0.148 | -3 | 0.764 |
HIPK2 |
0.771 | 0.128 | 1 | 0.679 |
DSTYK |
0.770 | 0.040 | 2 | 0.346 |
JNK2 |
0.770 | 0.160 | 1 | 0.682 |
CDK18 |
0.770 | 0.114 | 1 | 0.670 |
DAPK2 |
0.770 | 0.094 | -3 | 0.879 |
MAPKAPK2 |
0.770 | 0.064 | -3 | 0.765 |
LATS1 |
0.769 | 0.118 | -3 | 0.884 |
MSK2 |
0.769 | 0.075 | -3 | 0.768 |
MNK2 |
0.769 | 0.072 | -2 | 0.798 |
PKN3 |
0.768 | 0.002 | -3 | 0.838 |
TGFBR2 |
0.768 | -0.009 | -2 | 0.836 |
ATR |
0.768 | -0.002 | 1 | 0.781 |
NUAK2 |
0.768 | 0.051 | -3 | 0.859 |
MAPKAPK3 |
0.768 | 0.034 | -3 | 0.811 |
CHAK2 |
0.768 | 0.005 | -1 | 0.851 |
IKKE |
0.768 | -0.031 | 1 | 0.695 |
AURB |
0.768 | 0.094 | -2 | 0.695 |
PKCD |
0.768 | 0.018 | 2 | 0.240 |
PDHK4 |
0.767 | -0.113 | 1 | 0.813 |
ULK2 |
0.767 | -0.122 | 2 | 0.240 |
NIK |
0.767 | 0.027 | -3 | 0.881 |
BMPR2 |
0.767 | -0.022 | -2 | 0.868 |
HIPK1 |
0.767 | 0.123 | 1 | 0.767 |
PRKX |
0.766 | 0.111 | -3 | 0.718 |
PAK6 |
0.766 | 0.070 | -2 | 0.708 |
MNK1 |
0.766 | 0.078 | -2 | 0.803 |
PKCG |
0.766 | 0.028 | 2 | 0.239 |
P38B |
0.766 | 0.146 | 1 | 0.735 |
MYLK4 |
0.765 | 0.126 | -2 | 0.772 |
NEK6 |
0.765 | -0.050 | -2 | 0.858 |
SRPK3 |
0.765 | 0.070 | -3 | 0.730 |
CDK7 |
0.764 | 0.070 | 1 | 0.726 |
P38A |
0.764 | 0.131 | 1 | 0.796 |
MASTL |
0.764 | -0.058 | -2 | 0.787 |
PKCA |
0.764 | 0.016 | 2 | 0.211 |
PKG2 |
0.764 | 0.068 | -2 | 0.694 |
PKCB |
0.764 | 0.009 | 2 | 0.225 |
PLK1 |
0.764 | 0.043 | -2 | 0.827 |
JNK3 |
0.763 | 0.129 | 1 | 0.710 |
BMPR1B |
0.763 | 0.143 | 1 | 0.744 |
PASK |
0.763 | 0.228 | -3 | 0.872 |
MST4 |
0.763 | -0.018 | 2 | 0.262 |
GRK5 |
0.763 | -0.057 | -3 | 0.838 |
SGK3 |
0.763 | 0.073 | -3 | 0.799 |
PAK2 |
0.763 | 0.043 | -2 | 0.779 |
MARK4 |
0.762 | -0.018 | 4 | 0.753 |
DYRK3 |
0.762 | 0.151 | 1 | 0.763 |
PLK3 |
0.762 | 0.060 | 2 | 0.350 |
MLK1 |
0.762 | -0.071 | 2 | 0.271 |
AMPKA1 |
0.762 | -0.013 | -3 | 0.871 |
DYRK1A |
0.762 | 0.099 | 1 | 0.775 |
MLK2 |
0.762 | -0.019 | 2 | 0.255 |
RIPK1 |
0.761 | 0.004 | 1 | 0.787 |
TGFBR1 |
0.761 | 0.077 | -2 | 0.808 |
PLK4 |
0.761 | -0.015 | 2 | 0.229 |
CDK1 |
0.761 | 0.099 | 1 | 0.692 |
NEK7 |
0.761 | -0.102 | -3 | 0.852 |
DRAK1 |
0.761 | 0.185 | 1 | 0.751 |
MAK |
0.760 | 0.182 | -2 | 0.817 |
MLK3 |
0.760 | -0.030 | 2 | 0.231 |
CDK8 |
0.760 | 0.047 | 1 | 0.710 |
GRK6 |
0.760 | 0.016 | 1 | 0.773 |
IKKA |
0.760 | -0.018 | -2 | 0.688 |
CDK19 |
0.760 | 0.064 | 1 | 0.678 |
AURA |
0.759 | 0.080 | -2 | 0.686 |
BRSK1 |
0.759 | -0.004 | -3 | 0.811 |
PDHK1 |
0.759 | -0.170 | 1 | 0.792 |
DCAMKL1 |
0.759 | 0.056 | -3 | 0.809 |
CAMK4 |
0.759 | 0.004 | -3 | 0.839 |
DYRK1B |
0.759 | 0.118 | 1 | 0.704 |
TSSK2 |
0.759 | -0.001 | -5 | 0.771 |
ERK1 |
0.759 | 0.092 | 1 | 0.722 |
ULK1 |
0.759 | -0.123 | -3 | 0.807 |
TTBK2 |
0.759 | -0.104 | 2 | 0.225 |
DLK |
0.758 | 0.038 | 1 | 0.792 |
AKT2 |
0.758 | 0.086 | -3 | 0.714 |
AMPKA2 |
0.758 | -0.002 | -3 | 0.844 |
PRKD3 |
0.758 | 0.032 | -3 | 0.766 |
TSSK1 |
0.758 | -0.000 | -3 | 0.886 |
CDK14 |
0.758 | 0.104 | 1 | 0.705 |
NIM1 |
0.757 | -0.070 | 3 | 0.742 |
GRK7 |
0.757 | 0.057 | 1 | 0.731 |
PKCZ |
0.756 | -0.002 | 2 | 0.232 |
ALK4 |
0.756 | 0.033 | -2 | 0.828 |
WNK3 |
0.756 | -0.129 | 1 | 0.782 |
ANKRD3 |
0.756 | -0.059 | 1 | 0.819 |
PHKG1 |
0.756 | -0.039 | -3 | 0.845 |
GRK4 |
0.756 | -0.060 | -2 | 0.811 |
P38G |
0.756 | 0.093 | 1 | 0.619 |
CDK17 |
0.756 | 0.083 | 1 | 0.618 |
PKACA |
0.756 | 0.085 | -2 | 0.658 |
CDK10 |
0.756 | 0.103 | 1 | 0.694 |
PIM2 |
0.755 | 0.069 | -3 | 0.771 |
IRE1 |
0.755 | -0.079 | 1 | 0.775 |
HIPK3 |
0.755 | 0.086 | 1 | 0.772 |
BRSK2 |
0.755 | -0.032 | -3 | 0.837 |
BCKDK |
0.755 | -0.118 | -1 | 0.729 |
PKCH |
0.754 | -0.027 | 2 | 0.218 |
DCAMKL2 |
0.754 | 0.028 | -3 | 0.828 |
CAMK1G |
0.754 | 0.051 | -3 | 0.775 |
MELK |
0.754 | -0.022 | -3 | 0.829 |
NEK9 |
0.754 | -0.121 | 2 | 0.252 |
CDK5 |
0.753 | 0.051 | 1 | 0.741 |
ERK7 |
0.752 | 0.001 | 2 | 0.151 |
PAK4 |
0.752 | 0.057 | -2 | 0.694 |
MLK4 |
0.752 | -0.065 | 2 | 0.224 |
CDK13 |
0.751 | 0.039 | 1 | 0.703 |
ERK2 |
0.751 | 0.057 | 1 | 0.751 |
PKR |
0.750 | -0.022 | 1 | 0.798 |
DNAPK |
0.750 | 0.039 | 1 | 0.670 |
ATM |
0.750 | -0.012 | 1 | 0.702 |
P38D |
0.749 | 0.119 | 1 | 0.627 |
QSK |
0.749 | -0.013 | 4 | 0.725 |
CDK3 |
0.749 | 0.075 | 1 | 0.636 |
CDK12 |
0.749 | 0.050 | 1 | 0.681 |
TLK2 |
0.748 | -0.038 | 1 | 0.746 |
YSK4 |
0.748 | -0.013 | 1 | 0.742 |
GSK3A |
0.748 | 0.073 | 4 | 0.487 |
SNRK |
0.748 | -0.090 | 2 | 0.240 |
PAK5 |
0.748 | 0.046 | -2 | 0.676 |
ALK2 |
0.748 | 0.058 | -2 | 0.813 |
VRK2 |
0.748 | -0.079 | 1 | 0.833 |
MARK3 |
0.748 | 0.016 | 4 | 0.675 |
CDK9 |
0.748 | 0.037 | 1 | 0.711 |
CDK16 |
0.748 | 0.081 | 1 | 0.631 |
ACVR2B |
0.747 | 0.057 | -2 | 0.817 |
MEK1 |
0.747 | -0.051 | 2 | 0.324 |
IRE2 |
0.747 | -0.095 | 2 | 0.201 |
QIK |
0.746 | -0.065 | -3 | 0.858 |
ACVR2A |
0.746 | 0.026 | -2 | 0.815 |
SMMLCK |
0.745 | 0.080 | -3 | 0.830 |
NUAK1 |
0.745 | -0.043 | -3 | 0.811 |
NEK2 |
0.745 | -0.084 | 2 | 0.239 |
GSK3B |
0.745 | 0.048 | 4 | 0.482 |
MPSK1 |
0.744 | 0.056 | 1 | 0.794 |
MOK |
0.744 | 0.135 | 1 | 0.817 |
JNK1 |
0.744 | 0.111 | 1 | 0.661 |
SMG1 |
0.744 | -0.033 | 1 | 0.732 |
CHK1 |
0.744 | -0.016 | -3 | 0.862 |
PRP4 |
0.743 | 0.048 | -3 | 0.749 |
PKCT |
0.743 | -0.017 | 2 | 0.208 |
P70S6K |
0.743 | 0.023 | -3 | 0.739 |
MST3 |
0.743 | 0.028 | 2 | 0.301 |
SSTK |
0.742 | -0.014 | 4 | 0.717 |
PKCE |
0.742 | 0.015 | 2 | 0.224 |
CAMK1D |
0.742 | 0.037 | -3 | 0.713 |
GRK2 |
0.741 | -0.013 | -2 | 0.695 |
AKT1 |
0.741 | 0.048 | -3 | 0.740 |
DAPK3 |
0.741 | 0.085 | -3 | 0.815 |
CHAK1 |
0.740 | -0.128 | 2 | 0.230 |
NEK5 |
0.740 | -0.019 | 1 | 0.807 |
WNK4 |
0.740 | -0.051 | -2 | 0.835 |
MAPKAPK5 |
0.740 | -0.049 | -3 | 0.750 |
BMPR1A |
0.740 | 0.077 | 1 | 0.700 |
PERK |
0.740 | -0.096 | -2 | 0.835 |
CDK2 |
0.739 | 0.007 | 1 | 0.753 |
PKCI |
0.739 | -0.016 | 2 | 0.216 |
SIK |
0.739 | -0.049 | -3 | 0.785 |
DAPK1 |
0.739 | 0.095 | -3 | 0.797 |
MARK2 |
0.739 | -0.050 | 4 | 0.652 |
MEKK3 |
0.739 | -0.019 | 1 | 0.776 |
IRAK4 |
0.739 | -0.066 | 1 | 0.772 |
CK1E |
0.738 | -0.015 | -3 | 0.522 |
SGK1 |
0.738 | 0.068 | -3 | 0.643 |
TLK1 |
0.738 | -0.050 | -2 | 0.831 |
MARK1 |
0.738 | -0.030 | 4 | 0.692 |
AKT3 |
0.737 | 0.065 | -3 | 0.659 |
PLK2 |
0.737 | 0.035 | -3 | 0.753 |
ROCK2 |
0.737 | 0.091 | -3 | 0.816 |
GAK |
0.737 | 0.136 | 1 | 0.828 |
MEK5 |
0.737 | -0.114 | 2 | 0.286 |
MRCKB |
0.736 | 0.079 | -3 | 0.761 |
ZAK |
0.735 | -0.110 | 1 | 0.749 |
LKB1 |
0.734 | 0.050 | -3 | 0.846 |
TTBK1 |
0.734 | -0.122 | 2 | 0.209 |
STK33 |
0.734 | -0.039 | 2 | 0.237 |
MRCKA |
0.734 | 0.076 | -3 | 0.781 |
MEKK1 |
0.734 | -0.139 | 1 | 0.767 |
NEK11 |
0.733 | -0.012 | 1 | 0.776 |
HRI |
0.732 | -0.135 | -2 | 0.850 |
PHKG2 |
0.732 | -0.066 | -3 | 0.813 |
BRAF |
0.732 | -0.087 | -4 | 0.762 |
MEKK2 |
0.732 | -0.118 | 2 | 0.255 |
BUB1 |
0.732 | 0.078 | -5 | 0.745 |
YANK3 |
0.731 | -0.020 | 2 | 0.184 |
CK2A2 |
0.730 | 0.036 | 1 | 0.638 |
DMPK1 |
0.730 | 0.118 | -3 | 0.777 |
TAO3 |
0.730 | -0.057 | 1 | 0.769 |
GCK |
0.730 | 0.061 | 1 | 0.780 |
PKN1 |
0.729 | -0.015 | -3 | 0.759 |
GRK3 |
0.728 | -0.022 | -2 | 0.659 |
PDK1 |
0.728 | -0.033 | 1 | 0.775 |
MEKK6 |
0.728 | -0.033 | 1 | 0.801 |
CHK2 |
0.727 | 0.033 | -3 | 0.666 |
CDK6 |
0.727 | 0.033 | 1 | 0.688 |
CK1G1 |
0.727 | -0.054 | -3 | 0.501 |
CK1A2 |
0.727 | -0.018 | -3 | 0.471 |
CK1D |
0.727 | -0.013 | -3 | 0.471 |
CDK4 |
0.726 | 0.040 | 1 | 0.664 |
CAMK1A |
0.726 | 0.020 | -3 | 0.676 |
CRIK |
0.726 | 0.084 | -3 | 0.741 |
NEK8 |
0.725 | -0.109 | 2 | 0.262 |
CAMKK2 |
0.725 | -0.023 | -2 | 0.701 |
CK2A1 |
0.725 | 0.047 | 1 | 0.621 |
CAMKK1 |
0.724 | -0.054 | -2 | 0.694 |
HPK1 |
0.724 | 0.036 | 1 | 0.766 |
LOK |
0.724 | -0.027 | -2 | 0.749 |
PINK1 |
0.723 | -0.128 | 1 | 0.827 |
PBK |
0.723 | 0.043 | 1 | 0.770 |
MAP3K15 |
0.723 | -0.063 | 1 | 0.747 |
SBK |
0.722 | 0.047 | -3 | 0.602 |
PKG1 |
0.721 | 0.017 | -2 | 0.610 |
TNIK |
0.721 | -0.030 | 3 | 0.776 |
TAK1 |
0.721 | 0.012 | 1 | 0.788 |
ROCK1 |
0.720 | 0.066 | -3 | 0.777 |
NEK4 |
0.720 | -0.089 | 1 | 0.763 |
IRAK1 |
0.720 | -0.168 | -1 | 0.741 |
SLK |
0.720 | -0.013 | -2 | 0.707 |
HASPIN |
0.720 | 0.086 | -1 | 0.821 |
MST2 |
0.719 | -0.045 | 1 | 0.766 |
LRRK2 |
0.719 | -0.070 | 2 | 0.278 |
TAO2 |
0.719 | -0.118 | 2 | 0.262 |
NEK1 |
0.719 | -0.050 | 1 | 0.779 |
VRK1 |
0.719 | -0.061 | 2 | 0.294 |
EEF2K |
0.718 | -0.070 | 3 | 0.727 |
KHS1 |
0.716 | -0.017 | 1 | 0.754 |
PDHK3_TYR |
0.716 | 0.211 | 4 | 0.828 |
HGK |
0.715 | -0.090 | 3 | 0.770 |
KHS2 |
0.715 | -0.006 | 1 | 0.770 |
MINK |
0.714 | -0.086 | 1 | 0.768 |
MST1 |
0.713 | -0.047 | 1 | 0.755 |
TTK |
0.710 | -0.021 | -2 | 0.859 |
PDHK4_TYR |
0.709 | 0.210 | 2 | 0.367 |
MEK2 |
0.709 | -0.155 | 2 | 0.268 |
YSK1 |
0.708 | -0.112 | 2 | 0.233 |
RIPK2 |
0.707 | -0.149 | 1 | 0.701 |
OSR1 |
0.707 | -0.056 | 2 | 0.256 |
EPHA6 |
0.706 | 0.140 | -1 | 0.804 |
MAP2K6_TYR |
0.705 | 0.182 | -1 | 0.806 |
TNK2 |
0.704 | 0.151 | 3 | 0.750 |
BIKE |
0.704 | 0.018 | 1 | 0.722 |
LIMK2_TYR |
0.703 | 0.061 | -3 | 0.897 |
MAP2K4_TYR |
0.703 | 0.086 | -1 | 0.801 |
TESK1_TYR |
0.703 | 0.036 | 3 | 0.827 |
NEK3 |
0.702 | -0.122 | 1 | 0.748 |
EPHB4 |
0.702 | 0.147 | -1 | 0.768 |
BMPR2_TYR |
0.701 | 0.108 | -1 | 0.813 |
ASK1 |
0.701 | -0.085 | 1 | 0.728 |
PDHK1_TYR |
0.700 | 0.091 | -1 | 0.822 |
MAP2K7_TYR |
0.699 | -0.014 | 2 | 0.320 |
PKMYT1_TYR |
0.698 | -0.039 | 3 | 0.816 |
EPHA4 |
0.698 | 0.123 | 2 | 0.379 |
TXK |
0.697 | 0.168 | 1 | 0.781 |
CK1A |
0.697 | -0.037 | -3 | 0.374 |
MYO3B |
0.696 | -0.083 | 2 | 0.234 |
RET |
0.694 | 0.013 | 1 | 0.777 |
DDR1 |
0.694 | 0.045 | 4 | 0.728 |
ITK |
0.693 | 0.164 | -1 | 0.740 |
AAK1 |
0.693 | 0.047 | 1 | 0.641 |
YANK2 |
0.693 | -0.046 | 2 | 0.185 |
ABL2 |
0.692 | 0.072 | -1 | 0.740 |
SRMS |
0.691 | 0.147 | 1 | 0.783 |
DDR2 |
0.691 | 0.120 | 3 | 0.707 |
PINK1_TYR |
0.691 | -0.116 | 1 | 0.812 |
FGR |
0.691 | 0.038 | 1 | 0.842 |
MST1R |
0.690 | -0.015 | 3 | 0.784 |
TYRO3 |
0.690 | -0.013 | 3 | 0.738 |
YES1 |
0.690 | 0.044 | -1 | 0.799 |
MERTK |
0.690 | 0.060 | 3 | 0.771 |
PTK2 |
0.689 | 0.141 | -1 | 0.760 |
ABL1 |
0.689 | 0.059 | -1 | 0.735 |
EPHB3 |
0.689 | 0.091 | -1 | 0.749 |
FGFR2 |
0.689 | 0.022 | 3 | 0.782 |
EPHB1 |
0.689 | 0.094 | 1 | 0.785 |
CSF1R |
0.688 | 0.017 | 3 | 0.762 |
EPHA7 |
0.688 | 0.085 | 2 | 0.346 |
TNK1 |
0.688 | 0.010 | 3 | 0.740 |
TAO1 |
0.687 | -0.135 | 1 | 0.702 |
PTK2B |
0.687 | 0.108 | -1 | 0.720 |
EPHB2 |
0.687 | 0.091 | -1 | 0.744 |
MYO3A |
0.687 | -0.132 | 1 | 0.745 |
ALPHAK3 |
0.686 | -0.056 | -1 | 0.702 |
BLK |
0.686 | 0.106 | -1 | 0.784 |
LIMK1_TYR |
0.686 | -0.140 | 2 | 0.265 |
EPHA3 |
0.685 | 0.047 | 2 | 0.342 |
JAK3 |
0.685 | 0.003 | 1 | 0.763 |
KDR |
0.685 | 0.009 | 3 | 0.743 |
AXL |
0.685 | 0.009 | 3 | 0.760 |
STLK3 |
0.685 | -0.141 | 1 | 0.705 |
INSRR |
0.684 | -0.024 | 3 | 0.712 |
FYN |
0.683 | 0.107 | -1 | 0.768 |
ROS1 |
0.683 | -0.115 | 3 | 0.709 |
LCK |
0.683 | 0.057 | -1 | 0.781 |
BMX |
0.682 | 0.103 | -1 | 0.663 |
KIT |
0.682 | 0.035 | 3 | 0.768 |
EPHA5 |
0.681 | 0.092 | 2 | 0.375 |
MET |
0.681 | 0.025 | 3 | 0.771 |
JAK2 |
0.681 | -0.125 | 1 | 0.774 |
HCK |
0.681 | 0.005 | -1 | 0.775 |
FGFR3 |
0.681 | 0.031 | 3 | 0.761 |
FLT1 |
0.680 | 0.052 | -1 | 0.763 |
EPHA1 |
0.679 | 0.019 | 3 | 0.754 |
FER |
0.679 | -0.055 | 1 | 0.807 |
TEK |
0.679 | 0.002 | 3 | 0.698 |
FGFR1 |
0.678 | -0.059 | 3 | 0.738 |
TYK2 |
0.677 | -0.218 | 1 | 0.770 |
NEK10_TYR |
0.676 | -0.080 | 1 | 0.685 |
PDGFRB |
0.675 | -0.143 | 3 | 0.755 |
EPHA8 |
0.675 | 0.044 | -1 | 0.739 |
TEC |
0.674 | 0.025 | -1 | 0.677 |
EPHA2 |
0.673 | 0.082 | -1 | 0.708 |
TNNI3K_TYR |
0.673 | -0.093 | 1 | 0.789 |
LTK |
0.672 | -0.080 | 3 | 0.711 |
NTRK1 |
0.671 | -0.086 | -1 | 0.739 |
SRC |
0.671 | 0.034 | -1 | 0.759 |
FLT3 |
0.670 | -0.100 | 3 | 0.743 |
FLT4 |
0.670 | -0.052 | 3 | 0.741 |
JAK1 |
0.669 | -0.117 | 1 | 0.720 |
LYN |
0.668 | 0.019 | 3 | 0.695 |
FRK |
0.668 | -0.012 | -1 | 0.770 |
ERBB2 |
0.668 | -0.070 | 1 | 0.715 |
FGFR4 |
0.667 | -0.004 | -1 | 0.690 |
BTK |
0.667 | -0.058 | -1 | 0.709 |
NTRK3 |
0.666 | -0.069 | -1 | 0.686 |
CK1G3 |
0.666 | -0.059 | -3 | 0.323 |
CSK |
0.666 | -0.027 | 2 | 0.338 |
PDGFRA |
0.665 | -0.191 | 3 | 0.751 |
INSR |
0.665 | -0.103 | 3 | 0.693 |
WEE1_TYR |
0.664 | -0.101 | -1 | 0.691 |
ALK |
0.664 | -0.142 | 3 | 0.671 |
EGFR |
0.664 | -0.035 | 1 | 0.627 |
MATK |
0.664 | -0.034 | -1 | 0.669 |
PTK6 |
0.663 | -0.176 | -1 | 0.664 |
NTRK2 |
0.662 | -0.143 | 3 | 0.735 |
SYK |
0.662 | 0.052 | -1 | 0.714 |
ERBB4 |
0.658 | 0.014 | 1 | 0.627 |
CK1G2 |
0.656 | -0.036 | -3 | 0.418 |
IGF1R |
0.655 | -0.086 | 3 | 0.646 |
ZAP70 |
0.648 | 0.030 | -1 | 0.644 |
FES |
0.643 | -0.057 | -1 | 0.641 |
MUSK |
0.640 | -0.148 | 1 | 0.635 |