Motif 352 (n=63)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A6NDE4	RBMY1B	S176	ochoa	RNA-binding motif protein, Y chromosome, family 1 member B	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
A6NEQ0	RBMY1E	S176	ochoa	RNA-binding motif protein, Y chromosome, family 1 member E	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
A6QL63	ABTB3	S65	ochoa	Ankyrin repeat- and BTB/POZ domain-containing protein 3 (BTB/POZ domain-containing protein 11)	None
O14640	DVL1	S676	ochoa	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)	Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
O14641	DVL2	S717	ochoa	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)	Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250\|UniProtKB:Q60838, ECO:0000269\|PubMed:19252499, ECO:0000269\|PubMed:24616100}.
O14686	KMT2D	S2945	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O60493	SNX3	S72	ochoa	Sorting nexin-3 (Protein SDP3)	Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551). {ECO:0000250\|UniProtKB:O70492, ECO:0000269\|PubMed:11433298, ECO:0000269\|PubMed:18767904, ECO:0000269\|PubMed:21725319, ECO:0000269\|PubMed:23237080, ECO:0000269\|PubMed:24344282, ECO:0000305\|PubMed:21725319}.
O76090	BEST1	S358	psp	Bestrophin-1 (TU15B) (Vitelliform macular dystrophy protein 2)	Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:11904445, PubMed:12907679, PubMed:18179881, PubMed:18400985, PubMed:19853238, PubMed:21330666, PubMed:26200502, PubMed:26720466, PubMed:35789156). Allows the movement of chloride and hydrogencarbonate (PubMed:11904445, PubMed:12907679, PubMed:18179881, PubMed:18400985, PubMed:19853238, PubMed:21330666, PubMed:26200502, PubMed:26720466, PubMed:35789156). Found in a partially open conformation leading to significantly smaller chloride movement (PubMed:35789156). Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L-glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). Upon activation of the norepinephrine-alpha-1 adrenergic receptor signaling pathway, transports as well D-serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition (By similarity). Releases the 4-aminobutanoate neurotransmitter in a (Ca2+)-dependent manner, and participates in its tonic release from cerebellar glial cells (By similarity). {ECO:0000250\|UniProtKB:O88870, ECO:0000269\|PubMed:11904445, ECO:0000269\|PubMed:12907679, ECO:0000269\|PubMed:18179881, ECO:0000269\|PubMed:18400985, ECO:0000269\|PubMed:19853238, ECO:0000269\|PubMed:21330666, ECO:0000269\|PubMed:26200502, ECO:0000269\|PubMed:26720466, ECO:0000269\|PubMed:35789156}.
P07996	THBS1	S627	ochoa	Thrombospondin-1 (Glycoprotein G)	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:15014436, PubMed:18285447, PubMed:2430973, PubMed:6489349). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:14568985, PubMed:24511121, PubMed:29042481, PubMed:32679764). Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis (PubMed:14568985). Ligand for receptor CD47 (PubMed:19004835, PubMed:8550562). Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS (PubMed:29042481). Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 (PubMed:10613822, PubMed:11134179, PubMed:1371676). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:32679764). Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner (PubMed:29042481). Ligand for immunoglobulin-like cell surface receptor SIRPA (PubMed:24511121). Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA (PubMed:24511121). Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging (PubMed:29042481, PubMed:32679764). {ECO:0000250\|UniProtKB:P35441, ECO:0000269\|PubMed:10613822, ECO:0000269\|PubMed:11134179, ECO:0000269\|PubMed:1371676, ECO:0000269\|PubMed:14568985, ECO:0000269\|PubMed:15014436, ECO:0000269\|PubMed:18285447, ECO:0000269\|PubMed:19004835, ECO:0000269\|PubMed:2430973, ECO:0000269\|PubMed:24511121, ECO:0000269\|PubMed:29042481, ECO:0000269\|PubMed:32679764, ECO:0000269\|PubMed:6489349, ECO:0000269\|PubMed:8550562}.
P08138	NGFR	S277	psp	Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271)	Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250\|UniProtKB:Q9Z0W1, ECO:0000269\|PubMed:14966521, ECO:0000269\|PubMed:23785138, ECO:0000269\|PubMed:24908487, ECO:0000269\|PubMed:26646181, ECO:0000269\|PubMed:3022937}.
P08559	PDHA1	S293	ochoa\|psp	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269\|PubMed:19081061, ECO:0000269\|PubMed:7782287}.
P0C7P1	RBMY1D	S176	ochoa	RNA-binding motif protein, Y chromosome, family 1 member D	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
P0DJD3	RBMY1A1	S176	ochoa	RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY)	RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:8269511}.
P0DJD4	RBMY1C	S176	ochoa	RNA-binding motif protein, Y chromosome, family 1 member C	RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.
P25054	APC	S2290	ochoa	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250\|UniProtKB:Q61315, ECO:0000269\|PubMed:10947987, ECO:0000269\|PubMed:17293347, ECO:0000269\|PubMed:17599059, ECO:0000269\|PubMed:19151759, ECO:0000269\|PubMed:19893577, ECO:0000269\|PubMed:20937854}.
P29401	TKT	S276	ochoa	Transketolase (TK) (EC 2.2.1.1)	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269\|PubMed:27259054}.
P29803	PDHA2	S291	ochoa\|psp	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269\|PubMed:16436377}.
P38159	RBMX	S175	ochoa	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:12761049, ECO:0000269\|PubMed:16707624, ECO:0000269\|PubMed:18445477, ECO:0000269\|PubMed:18541147, ECO:0000269\|PubMed:19282290, ECO:0000269\|PubMed:21327109}.
P42331	ARHGAP25	S487	ochoa\|psp	Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
P52179	MYOM1	S1615	ochoa	Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1)	Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P54792	DVL1P1	S651	ochoa	Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like)	May play a role in the signal transduction pathway mediated by multiple Wnt genes.
P67809	YBX1	S136	ochoa	Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)	DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250\|UniProtKB:P62960, ECO:0000250\|UniProtKB:Q28618, ECO:0000269\|PubMed:10817758, ECO:0000269\|PubMed:11698476, ECO:0000269\|PubMed:12604611, ECO:0000269\|PubMed:14718551, ECO:0000269\|PubMed:18809583, ECO:0000269\|PubMed:19029303, ECO:0000269\|PubMed:19483673, ECO:0000269\|PubMed:19561594, ECO:0000269\|PubMed:27559612, ECO:0000269\|PubMed:28341602, ECO:0000269\|PubMed:29073095, ECO:0000269\|PubMed:29712925, ECO:0000269\|PubMed:31358969, ECO:0000269\|PubMed:8188694}.
P67809	YBX1	S209	ochoa\|psp	Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)	DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250\|UniProtKB:P62960, ECO:0000250\|UniProtKB:Q28618, ECO:0000269\|PubMed:10817758, ECO:0000269\|PubMed:11698476, ECO:0000269\|PubMed:12604611, ECO:0000269\|PubMed:14718551, ECO:0000269\|PubMed:18809583, ECO:0000269\|PubMed:19029303, ECO:0000269\|PubMed:19483673, ECO:0000269\|PubMed:19561594, ECO:0000269\|PubMed:27559612, ECO:0000269\|PubMed:28341602, ECO:0000269\|PubMed:29073095, ECO:0000269\|PubMed:29712925, ECO:0000269\|PubMed:31358969, ECO:0000269\|PubMed:8188694}.
Q12888	TP53BP1	S96	ochoa	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250\|UniProtKB:P70399, ECO:0000269\|PubMed:12364621, ECO:0000269\|PubMed:17190600, ECO:0000269\|PubMed:21144835, ECO:0000269\|PubMed:22553214, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:23345425, ECO:0000269\|PubMed:23727112, ECO:0000269\|PubMed:23760478, ECO:0000269\|PubMed:27153538, ECO:0000269\|PubMed:28241136, ECO:0000269\|PubMed:31135337, ECO:0000269\|PubMed:37696958}.
Q12888	TP53BP1	S1618	ochoa\|psp	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250\|UniProtKB:P70399, ECO:0000269\|PubMed:12364621, ECO:0000269\|PubMed:17190600, ECO:0000269\|PubMed:21144835, ECO:0000269\|PubMed:22553214, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:23345425, ECO:0000269\|PubMed:23727112, ECO:0000269\|PubMed:23760478, ECO:0000269\|PubMed:27153538, ECO:0000269\|PubMed:28241136, ECO:0000269\|PubMed:31135337, ECO:0000269\|PubMed:37696958}.
Q15061	WDR43	S427	ochoa	WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)	Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250\|UniProtKB:Q6ZQL4, ECO:0000269\|PubMed:17699751, ECO:0000269\|PubMed:34516797}.
Q15345	LRRC41	S276	ochoa	Leucine-rich repeat-containing protein 41 (Protein Muf1)	Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269\|PubMed:15601820}.
Q15415	RBMY1F	S176	ochoa	RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2)	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. {ECO:0000269\|PubMed:8269511}.
Q15772	SPEG	S2566	ochoa	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)	Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q29RF7	PDS5A	S1223	ochoa	Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112)	Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269\|PubMed:15855230, ECO:0000269\|PubMed:19907496}.
Q460N5	PARP14	S33	ochoa	Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14)	ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:18851833, PubMed:25043379, PubMed:27796300). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). {ECO:0000269\|PubMed:16061477, ECO:0000269\|PubMed:18851833, ECO:0000269\|PubMed:25043379, ECO:0000269\|PubMed:27796300, ECO:0000305\|PubMed:29858569}.
Q5VT52	RPRD2	S1099	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q69YH5	CDCA2	S24	ochoa	Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man)	Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269\|PubMed:16492807, ECO:0000269\|PubMed:16998479}.
Q6P0Q8	MAST2	S883	ochoa	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6T4R5	NHS	S533	ochoa	Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein)	May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269\|PubMed:20332100}.
Q6ZNL6	FGD5	S552	ochoa	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)	Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269\|PubMed:22328776}.
Q70EL4	USP43	S796	ochoa	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43)	May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}.
Q75N03	CBLL1	S278	ochoa	E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai)	E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). {ECO:0000250\|UniProtKB:Q9JIY2, ECO:0000269\|PubMed:29507755}.
Q7Z591	AKNA	S889	ochoa	Microtubule organization protein AKNA (AT-hook-containing transcription factor)	Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250\|UniProtKB:Q80VW7, ECO:0000269\|PubMed:11268217, ECO:0000305}.
Q8NFW9	MYRIP	S295	ochoa	Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c)	Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.
Q8NHV4	NEDD1	S426	ochoa\|psp	Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1)	Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269\|PubMed:19029337, ECO:0000269\|PubMed:19509060}.
Q8WWL2	SPIRE2	S387	ochoa	Protein spire homolog 2 (Spir-2)	Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). {ECO:0000250\|UniProtKB:Q8K1S6, ECO:0000269\|PubMed:21620703, ECO:0000269\|PubMed:26287480}.
Q8WY91	THAP4	S237	ochoa	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4)	Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269\|PubMed:30524950, ECO:0000269\|PubMed:32295384}.
Q92997	DVL3	S697	ochoa\|psp	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)	Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250\|UniProtKB:Q61062}.
Q96E39	RBMXL1	S175	ochoa	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96MK2	RIPOR3	S24	ochoa	RIPOR family member 3	None
Q96PN7	TRERF1	S618	ochoa	Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132)	Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269\|PubMed:11349124, ECO:0000269\|PubMed:16371131}.
Q96QB1	DLC1	S842	ochoa	Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12)	Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269\|PubMed:18786931, ECO:0000269\|PubMed:19170769, ECO:0000269\|PubMed:19710422, ECO:0000269\|PubMed:26166433}.
Q96ST3	SIN3A	S450	ochoa	Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)	Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250\|UniProtKB:Q60520, ECO:0000269\|PubMed:12150998}.
Q9BY89	KIAA1671	S1156	ochoa	Uncharacterized protein KIAA1671	None
Q9BYB0	SHANK3	S1613	ochoa	SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)	Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269\|PubMed:24132240}.
Q9C0J8	WDR33	S1279	ochoa	pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)	Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269\|PubMed:19217410}.
Q9H0W5	CCDC8	S103	ochoa	Coiled-coil domain-containing protein 8	Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269\|PubMed:24793695, ECO:0000269\|PubMed:24793696}.
Q9H2D6	TRIOBP	S805	ochoa	TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin)	[Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269\|PubMed:18194665, ECO:0000269\|PubMed:22820163, ECO:0000269\|PubMed:24692559, ECO:0000269\|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250\|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250\|UniProtKB:Q99KW3}.
Q9H910	JPT2	S45	ochoa	Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein)	Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269\|PubMed:33758061, ECO:0000269\|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269\|PubMed:33758061}.
Q9NPI6	DCP1A	S451	ochoa	mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)	Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269\|PubMed:11836524, ECO:0000269\|PubMed:12417715, ECO:0000269\|PubMed:33813271}.
Q9NRM7	LATS2	S172	psp	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269\|PubMed:10871863, ECO:0000269\|PubMed:12853976, ECO:0000269\|PubMed:15131260, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:21952048, ECO:0000269\|PubMed:26437443, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:34404733, ECO:0000269\|PubMed:39173637}.
Q9NWH9	SLTM	S815	ochoa	SAFB-like transcription modulator (Modulator of estrogen-induced transcription)	When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9P206	NHSL3	S912	ochoa	NHS-like protein 3	Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269\|PubMed:32854746}.
Q9UMY4	SNX12	S73	ochoa	Sorting nexin-12	May be involved in several stages of intracellular trafficking. {ECO:0000250}.
Q9Y3R5	DOP1B	S1169	ochoa	Protein DOP1B	May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269\|PubMed:30213940}.
Q9Y450	HBS1L	S213	ochoa	HBS1-like protein (EC 3.6.5.-) (ERFS)	GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269\|PubMed:21448132, ECO:0000269\|PubMed:23667253, ECO:0000269\|PubMed:27863242, ECO:0000269\|PubMed:32006463}.
P08174	CD55	S54	Sugiyama	Complement decay-accelerating factor (CD antigen CD55)	This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269\|PubMed:7525274, ECO:0000305\|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269\|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269\|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269\|PubMed:7525274, ECO:0000305\|PubMed:12409401}.

Download

reactome_id	name	p	-log10_p
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.000002	5.811
R-HSA-201688	WNT mediated activation of DVL	0.000021	4.680
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.000014	4.863
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	0.000020	4.689
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	0.000094	4.025
R-HSA-9664420	Killing mechanisms	0.000094	4.025
R-HSA-4641258	Degradation of DVL	0.000934	3.030
R-HSA-201681	TCF dependent signaling in response to WNT	0.001794	2.746
R-HSA-9818028	NFE2L2 regulates pentose phosphate pathway genes	0.001953	2.709
R-HSA-9861559	PDH complex synthesizes acetyl-CoA from PYR	0.002495	2.603
R-HSA-195721	Signaling by WNT	0.002457	2.610
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.004276	2.369
R-HSA-9675151	Disorders of Developmental Biology	0.003765	2.424
R-HSA-2028269	Signaling by Hippo	0.004120	2.385
R-HSA-429914	Deadenylation-dependent mRNA decay	0.003075	2.512
R-HSA-8878171	Transcriptional regulation by RUNX1	0.004160	2.381
R-HSA-4086400	PCP/CE pathway	0.006138	2.212
R-HSA-204174	Regulation of pyruvate dehydrogenase (PDH) complex	0.010063	1.997
R-HSA-205017	NFG and proNGF binds to p75NTR	0.012774	1.894
R-HSA-162582	Signal Transduction	0.014600	1.836
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.015516	1.809
R-HSA-209563	Axonal growth stimulation	0.021200	1.674
R-HSA-9944997	Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	0.021200	1.674
R-HSA-9944971	Loss of Function of KMT2D in Kabuki Syndrome	0.021200	1.674
R-HSA-205025	NADE modulates death signalling	0.025386	1.595
R-HSA-9017802	Noncanonical activation of NOTCH3	0.033707	1.472
R-HSA-2470946	Cohesin Loading onto Chromatin	0.041957	1.377
R-HSA-193692	Regulated proteolysis of p75NTR	0.050138	1.300
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.054202	1.266
R-HSA-4839744	Signaling by APC mutants	0.058250	1.235
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.058250	1.235
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.058250	1.235
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.058250	1.235
R-HSA-5339716	Signaling by GSK3beta mutants	0.062280	1.206
R-HSA-209543	p75NTR recruits signalling complexes	0.066293	1.179
R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	0.066293	1.179
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	0.066293	1.179
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	0.066293	1.179
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	0.066293	1.179
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	0.066293	1.179
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	0.037535	1.426
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.037535	1.426
R-HSA-8854518	AURKA Activation by TPX2	0.040443	1.393
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.047547	1.323
R-HSA-380287	Centrosome maturation	0.049655	1.304
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.065306	1.185
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.067662	1.170
R-HSA-193697	p75NTR regulates axonogenesis	0.050138	1.300
R-HSA-193634	Axonal growth inhibition (RHOA activation)	0.046056	1.337
R-HSA-163754	Insulin effects increased synthesis of Xylulose-5-Phosphate	0.041957	1.377
R-HSA-9022538	Loss of MECP2 binding ability to 5mC-DNA	0.021200	1.674
R-HSA-111446	Activation of BIM and translocation to mitochondria	0.021200	1.674
R-HSA-193681	Ceramide signalling	0.033707	1.472
R-HSA-209560	NF-kB is activated and signals survival	0.062280	1.206
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.062280	1.206
R-HSA-4839735	Signaling by AXIN mutants	0.062280	1.206
R-HSA-4839748	Signaling by AMER1 mutants	0.062280	1.206
R-HSA-68877	Mitotic Prometaphase	0.063039	1.200
R-HSA-427413	NoRC negatively regulates rRNA expression	0.045473	1.342
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.058250	1.235
R-HSA-193670	p75NTR negatively regulates cell cycle via SC1	0.025386	1.595
R-HSA-9706019	RHOBTB3 ATPase cycle	0.058250	1.235
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.059543	1.225
R-HSA-3858494	Beta-catenin independent WNT signaling	0.028246	1.549
R-HSA-9022702	MECP2 regulates transcription of neuronal ligands	0.054202	1.266
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.055069	1.259
R-HSA-9005895	Pervasive developmental disorders	0.066293	1.179
R-HSA-9697154	Disorders of Nervous System Development	0.066293	1.179
R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.066293	1.179
R-HSA-9861718	Regulation of pyruvate metabolism	0.022740	1.643
R-HSA-70268	Pyruvate metabolism	0.064139	1.193
R-HSA-9659379	Sensory processing of sound	0.053970	1.268
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	0.042428	1.372
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	0.031084	1.507
R-HSA-9683610	Maturation of nucleoprotein	0.070290	1.153
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.049655	1.304
R-HSA-5362517	Signaling by Retinoic Acid	0.034711	1.460
R-HSA-8953854	Metabolism of RNA	0.073497	1.134
R-HSA-205043	NRIF signals cell death from the nucleus	0.074269	1.129
R-HSA-196299	Beta-catenin phosphorylation cascade	0.078232	1.107
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.086107	1.065
R-HSA-5083635	Defective B3GALTL causes PpS	0.154066	0.812
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	0.172043	0.764
R-HSA-72165	mRNA Splicing - Minor Pathway	0.206875	0.684
R-HSA-72187	mRNA 3'-end processing	0.227076	0.644
R-HSA-193639	p75NTR signals via NF-kB	0.078232	1.107
R-HSA-5099900	WNT5A-dependent internalization of FZD4	0.082178	1.085
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.114282	0.942
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.137027	0.863
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	0.186153	0.730
R-HSA-4791275	Signaling by WNT in cancer	0.150425	0.823
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.120734	0.918
R-HSA-6807878	COPI-mediated anterograde transport	0.077360	1.111
R-HSA-5620924	Intraflagellar transport	0.213666	0.670
R-HSA-9766229	Degradation of CDH1	0.217040	0.663
R-HSA-4608870	Asymmetric localization of PCP proteins	0.203458	0.692
R-HSA-2467813	Separation of Sister Chromatids	0.183532	0.736
R-HSA-9701898	STAT3 nuclear events downstream of ALK signaling	0.078232	1.107
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.086107	1.065
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	0.097796	1.010
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.179128	0.747
R-HSA-9646399	Aggrephagy	0.182648	0.738
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.213666	0.670
R-HSA-5617833	Cilium Assembly	0.225633	0.647
R-HSA-212165	Epigenetic regulation of gene expression	0.182155	0.740
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.078232	1.107
R-HSA-3238698	WNT ligand biogenesis and trafficking	0.113152	0.946
R-HSA-429947	Deadenylation of mRNA	0.120734	0.918
R-HSA-5656169	Termination of translesion DNA synthesis	0.139408	0.856
R-HSA-6794361	Neurexins and neuroligins	0.227076	0.644
R-HSA-71336	Pentose phosphate pathway	0.179128	0.747
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	0.078232	1.107
R-HSA-8876384	Listeria monocytogenes entry into host cells	0.109338	0.961
R-HSA-9022699	MECP2 regulates neuronal receptors and channels	0.128251	0.892
R-HSA-199977	ER to Golgi Anterograde Transport	0.157714	0.802
R-HSA-3214841	PKMTs methylate histone lysines	0.186153	0.730
R-HSA-69275	G2/M Transition	0.219336	0.659
R-HSA-9824594	Regulation of MITF-M-dependent genes involved in apoptosis	0.105507	0.977
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	0.113152	0.946
R-HSA-453274	Mitotic G2-G2/M phases	0.222482	0.653
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.182648	0.738
R-HSA-9825892	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	0.109338	0.961
R-HSA-201556	Signaling by ALK	0.179128	0.747
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.172043	0.764
R-HSA-9694631	Maturation of nucleoprotein	0.097796	1.010
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in ...	0.113152	0.946
R-HSA-9022692	Regulation of MECP2 expression and activity	0.154066	0.812
R-HSA-5689896	Ovarian tumor domain proteases	0.172043	0.764
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa...	0.186153	0.730
R-HSA-3000170	Syndecan interactions	0.116951	0.932
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	0.164898	0.783
R-HSA-9824443	Parasitic Infection Pathways	0.138985	0.857
R-HSA-9658195	Leishmania infection	0.138985	0.857
R-HSA-264876	Insulin processing	0.131986	0.879
R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.189643	0.722
R-HSA-73893	DNA Damage Bypass	0.217040	0.663
R-HSA-114452	Activation of BH3-only proteins	0.143096	0.844
R-HSA-9856651	MITF-M-dependent gene expression	0.162218	0.790
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	0.203458	0.692
R-HSA-8853659	RET signaling	0.168478	0.773
R-HSA-9683701	Translation of Structural Proteins	0.189643	0.722
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.150425	0.823
R-HSA-9759194	Nuclear events mediated by NFE2L2	0.114282	0.942
R-HSA-75153	Apoptotic execution phase	0.206875	0.684
R-HSA-9711123	Cellular response to chemical stress	0.126434	0.898
R-HSA-9755511	KEAP1-NFE2L2 pathway	0.163725	0.786
R-HSA-109581	Apoptosis	0.180460	0.744
R-HSA-72163	mRNA Splicing - Major Pathway	0.231943	0.635
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	0.236986	0.625
R-HSA-9012852	Signaling by NOTCH3	0.236986	0.625
R-HSA-193648	NRAGE signals death through JNK	0.240262	0.619
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.240262	0.619
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.240262	0.619
R-HSA-9764561	Regulation of CDH1 Function	0.243523	0.613
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.243523	0.613
R-HSA-948021	Transport to the Golgi and subsequent modification	0.244599	0.612
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.246771	0.608
R-HSA-68886	M Phase	0.248933	0.604
R-HSA-72172	mRNA Splicing	0.249354	0.603
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.250005	0.602
R-HSA-5357801	Programmed Cell Death	0.250940	0.600
R-HSA-73856	RNA Polymerase II Transcription Termination	0.256432	0.591
R-HSA-186797	Signaling by PDGF	0.259625	0.586
R-HSA-6790901	rRNA modification in the nucleus and cytosol	0.262804	0.580
R-HSA-9730414	MITF-M-regulated melanocyte development	0.263636	0.579
R-HSA-68882	Mitotic Anaphase	0.268400	0.571
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.269988	0.569
R-HSA-5693606	DNA Double Strand Break Response	0.275388	0.560
R-HSA-196807	Nicotinate metabolism	0.275388	0.560
R-HSA-8951664	Neddylation	0.276340	0.559
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	0.278501	0.555
R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.284687	0.546
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	0.287761	0.541
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	0.290821	0.536
R-HSA-597592	Post-translational protein modification	0.290942	0.536
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.293869	0.532
R-HSA-69473	G2/M DNA damage checkpoint	0.296903	0.527
R-HSA-9694635	Translation of Structural Proteins	0.305930	0.514
R-HSA-216083	Integrin cell surface interactions	0.308914	0.510
R-HSA-73857	RNA Polymerase II Transcription	0.312088	0.506
R-HSA-5693607	Processing of DNA double-strand break ends	0.317788	0.498
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.320722	0.494
R-HSA-9707564	Cytoprotection by HMOX1	0.323642	0.490
R-HSA-6794362	Protein-protein interactions at synapses	0.329447	0.482
R-HSA-5688426	Deubiquitination	0.330086	0.481
R-HSA-141424	Amplification of signal from the kinetochores	0.332331	0.478
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.332331	0.478
R-HSA-69620	Cell Cycle Checkpoints	0.334790	0.475
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.335202	0.475
R-HSA-6798695	Neutrophil degranulation	0.336543	0.473
R-HSA-9663891	Selective autophagy	0.340909	0.467
R-HSA-392499	Metabolism of proteins	0.344799	0.462
R-HSA-373080	Class B/2 (Secretin family receptors)	0.346567	0.460
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	0.349379	0.457
R-HSA-8986944	Transcriptional Regulation by MECP2	0.349379	0.457
R-HSA-9772573	Late SARS-CoV-2 Infection Events	0.354966	0.450
R-HSA-9837999	Mitochondrial protein degradation	0.360505	0.443
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.371444	0.430
R-HSA-193704	p75 NTR receptor-mediated signalling	0.376844	0.424
R-HSA-9614085	FOXO-mediated transcription	0.376844	0.424
R-HSA-69618	Mitotic Spindle Checkpoint	0.379527	0.421
R-HSA-1640170	Cell Cycle	0.381069	0.419
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.390145	0.409
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	0.392771	0.406
R-HSA-5619507	Activation of HOX genes during differentiation	0.392771	0.406
R-HSA-2672351	Stimuli-sensing channels	0.403165	0.395
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.405737	0.392
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	0.413385	0.384
R-HSA-927802	Nonsense-Mediated Decay (NMD)	0.413385	0.384
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.418429	0.378
R-HSA-1852241	Organelle biogenesis and maintenance	0.429290	0.367
R-HSA-2980736	Peptide hormone metabolism	0.430855	0.366
R-HSA-5693538	Homology Directed Repair	0.433308	0.363
R-HSA-1474244	Extracellular matrix organization	0.445369	0.351
R-HSA-9816359	Maternal to zygotic transition (MZT)	0.445420	0.351
R-HSA-2132295	MHC class II antigen presentation	0.445420	0.351
R-HSA-977606	Regulation of Complement cascade	0.450193	0.347
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	0.452565	0.344
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	0.452565	0.344
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	0.452565	0.344
R-HSA-114608	Platelet degranulation	0.457277	0.340
R-HSA-69481	G2/M Checkpoints	0.457277	0.340
R-HSA-1428517	Aerobic respiration and respiratory electron transport	0.459773	0.337
R-HSA-69278	Cell Cycle, Mitotic	0.462534	0.335
R-HSA-8856688	Golgi-to-ER retrograde transport	0.471176	0.327
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.473458	0.325
R-HSA-163685	Integration of energy metabolism	0.482490	0.317
R-HSA-5173105	O-linked glycosylation	0.484724	0.315
R-HSA-74160	Gene expression (Transcription)	0.485340	0.314
R-HSA-73894	DNA Repair	0.486549	0.313
R-HSA-9948299	Ribosome-associated quality control	0.486949	0.313
R-HSA-9006931	Signaling by Nuclear Receptors	0.490703	0.309
R-HSA-1632852	Macroautophagy	0.493565	0.307
R-HSA-8856828	Clathrin-mediated endocytosis	0.500098	0.301
R-HSA-166658	Complement cascade	0.504407	0.297
R-HSA-69242	S Phase	0.510802	0.292
R-HSA-212436	Generic Transcription Pathway	0.516775	0.287
R-HSA-5693532	DNA Double-Strand Break Repair	0.521280	0.283
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	0.523349	0.281
R-HSA-73887	Death Receptor Signaling	0.523349	0.281
R-HSA-9612973	Autophagy	0.527460	0.278
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	0.529502	0.276
R-HSA-877300	Interferon gamma signaling	0.533562	0.273
R-HSA-9006936	Signaling by TGFB family members	0.535578	0.271
R-HSA-199991	Membrane Trafficking	0.550574	0.259
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.557201	0.254
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	0.562924	0.250
R-HSA-9764265	Regulation of CDH1 Expression and Function	0.562924	0.250
R-HSA-5689880	Ub-specific processing proteases	0.562924	0.250
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.566699	0.247
R-HSA-9678108	SARS-CoV-1 Infection	0.566699	0.247
R-HSA-446203	Asparagine N-linked glycosylation	0.569308	0.245
R-HSA-3781865	Diseases of glycosylation	0.583291	0.234
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.590463	0.229
R-HSA-983712	Ion channel transport	0.592237	0.228
R-HSA-9609690	HCMV Early Events	0.604444	0.219
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	0.604444	0.219
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.611257	0.214
R-HSA-418990	Adherens junctions interactions	0.642071	0.192
R-HSA-2262752	Cellular responses to stress	0.657861	0.182
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.660279	0.180
R-HSA-72312	rRNA processing	0.663224	0.178
R-HSA-3247509	Chromatin modifying enzymes	0.666143	0.176
R-HSA-157118	Signaling by NOTCH	0.674753	0.171
R-HSA-4839726	Chromatin organization	0.687259	0.163
R-HSA-9609646	HCMV Infection	0.688618	0.162
R-HSA-421270	Cell-cell junction organization	0.689973	0.161
R-HSA-5653656	Vesicle-mediated transport	0.696109	0.157
R-HSA-76002	Platelet activation, signaling and aggregation	0.719563	0.143
R-HSA-446728	Cell junction organization	0.724417	0.140
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	0.729189	0.137
R-HSA-8953897	Cellular responses to stimuli	0.744961	0.128
R-HSA-5663205	Infectious disease	0.755230	0.122
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.760506	0.119
R-HSA-1500931	Cell-Cell communication	0.766591	0.115
R-HSA-9694516	SARS-CoV-2 Infection	0.798009	0.098
R-HSA-1643685	Disease	0.802830	0.095
R-HSA-196854	Metabolism of vitamins and cofactors	0.810874	0.091
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.826780	0.083
R-HSA-913531	Interferon Signaling	0.826780	0.083
R-HSA-9824439	Bacterial Infection Pathways	0.832029	0.080
R-HSA-5668914	Diseases of metabolism	0.857277	0.067
R-HSA-72766	Translation	0.858530	0.066
R-HSA-109582	Hemostasis	0.865450	0.063
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	0.873861	0.059
R-HSA-3700989	Transcriptional Regulation by TP53	0.879311	0.056
R-HSA-112316	Neuronal System	0.880901	0.055
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.903268	0.044
R-HSA-422475	Axon guidance	0.915323	0.038
R-HSA-9679506	SARS-CoV Infections	0.919002	0.037
R-HSA-9675108	Nervous system development	0.928168	0.032
R-HSA-500792	GPCR ligand binding	0.930372	0.031
R-HSA-1266738	Developmental Biology	0.935167	0.029
R-HSA-168249	Innate Immune System	0.935899	0.029
R-HSA-1280218	Adaptive Immune System	0.947982	0.023
R-HSA-9824446	Viral Infection Pathways	0.961735	0.017
R-HSA-9709957	Sensory Perception	0.974998	0.011
R-HSA-372790	Signaling by GPCR	0.979113	0.009
R-HSA-382551	Transport of small molecules	0.988120	0.005
R-HSA-1280215	Cytokine Signaling in Immune system	0.992243	0.003
R-HSA-168256	Immune System	0.995538	0.002
R-HSA-556833	Metabolism of lipids	0.998874	0.000
R-HSA-1430728	Metabolism	0.999903	0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
PRKD1	0.800	0.446	-3	0.793
PRKD2	0.799	0.464	-3	0.827
RSK3	0.788	0.443	-3	0.851
MAPKAPK2	0.788	0.434	-3	0.825
MAPKAPK3	0.787	0.434	-3	0.814
PRKD3	0.786	0.463	-3	0.840
P90RSK	0.785	0.451	-3	0.847
NDR2	0.785	0.293	-3	0.757
SRPK2	0.784	0.421	-3	0.846
RSK2	0.784	0.428	-3	0.849
PKN3	0.784	0.413	-3	0.796
MSK2	0.783	0.433	-3	0.838
SRPK1	0.783	0.401	-3	0.846
PIM3	0.783	0.383	-3	0.804
PIM1	0.782	0.434	-3	0.834
NUAK2	0.781	0.378	-3	0.818
LATS2	0.780	0.267	-5	0.657
NUAK1	0.780	0.369	-3	0.817
CAMK2D	0.779	0.339	-3	0.771
MELK	0.779	0.406	-3	0.803
AMPKA2	0.778	0.363	-3	0.801
NDR1	0.778	0.314	-3	0.787
AKT2	0.778	0.467	-3	0.853
PKACB	0.778	0.359	-2	0.642
CAMK1B	0.777	0.409	-3	0.795
CDKL1	0.776	0.428	-3	0.836
PKACG	0.776	0.305	-2	0.702
AMPKA1	0.776	0.328	-3	0.784
P70S6KB	0.776	0.394	-3	0.830
HIPK4	0.775	0.286	1	0.726
TSSK1	0.774	0.306	-3	0.780
CAMK1D	0.774	0.463	-3	0.829
SGK3	0.774	0.423	-3	0.826
CAMK4	0.774	0.335	-3	0.781
MSK1	0.773	0.384	-3	0.838
RSK4	0.773	0.407	-3	0.837
PKACA	0.772	0.369	-2	0.594
SRPK3	0.772	0.373	-3	0.833
CAMK2B	0.772	0.297	2	0.688
AKT1	0.772	0.430	-3	0.845
PRKX	0.772	0.367	-3	0.810
PKN2	0.772	0.314	-3	0.777
CAMK1A	0.772	0.474	-3	0.826
SIK	0.772	0.334	-3	0.808
CAMK2A	0.771	0.322	2	0.684
BRSK1	0.771	0.311	-3	0.815
P70S6K	0.771	0.422	-3	0.843
MAPKAPK5	0.771	0.389	-3	0.836
CAMK1G	0.771	0.399	-3	0.836
CDKL5	0.771	0.346	-3	0.843
GCN2	0.770	0.055	2	0.688
PKCD	0.770	0.275	2	0.698
AKT3	0.769	0.459	-3	0.843
PIM2	0.769	0.420	-3	0.849
SKMLCK	0.769	0.292	-2	0.787
PHKG1	0.769	0.304	-3	0.784
BRSK2	0.769	0.257	-3	0.782
COT	0.769	0.067	2	0.732
DCAMKL1	0.769	0.423	-3	0.814
SBK	0.768	0.498	-3	0.832
MTOR	0.768	0.064	1	0.798
TSSK2	0.768	0.277	-5	0.775
SGK1	0.768	0.482	-3	0.838
ICK	0.767	0.340	-3	0.816
RAF1	0.767	0.144	1	0.808
CAMLCK	0.767	0.329	-2	0.788
WNK1	0.767	0.179	-2	0.785
NIM1	0.767	0.199	3	0.655
PAK1	0.767	0.248	-2	0.730
TBK1	0.767	0.066	1	0.782
MNK2	0.767	0.227	-2	0.735
PKN1	0.766	0.428	-3	0.844
PAK3	0.765	0.230	-2	0.734
AURC	0.764	0.209	-2	0.633
MST4	0.764	0.156	2	0.706
PKG2	0.764	0.273	-2	0.637
BCKDK	0.764	0.064	-1	0.759
NEK6	0.764	0.059	-2	0.764
PRPK	0.764	0.050	-1	0.767
ULK2	0.764	0.027	2	0.712
CLK3	0.763	0.186	1	0.683
CHK2	0.763	0.478	-3	0.840
DAPK2	0.763	0.357	-3	0.778
NIK	0.763	0.308	-3	0.738
PDHK4	0.762	-0.031	1	0.830
MYLK4	0.762	0.318	-2	0.738
DYRK1A	0.762	0.318	1	0.668
PKCA	0.761	0.206	2	0.641
MARK4	0.761	0.120	4	0.750
CDC7	0.761	0.028	1	0.680
CHK1	0.761	0.283	-3	0.762
HUNK	0.761	0.067	2	0.664
IKKE	0.761	0.019	1	0.761
PKCB	0.760	0.224	2	0.635
IKKB	0.760	0.029	-2	0.675
DYRK2	0.760	0.214	1	0.600
PDHK1	0.760	-0.013	1	0.819
SNRK	0.760	0.216	2	0.658
QSK	0.760	0.218	4	0.727
ATR	0.759	0.086	1	0.783
AURB	0.759	0.207	-2	0.635
AURA	0.759	0.209	-2	0.625
WNK3	0.759	0.071	1	0.831
CLK4	0.759	0.328	-3	0.844
CAMK2G	0.759	0.039	2	0.720
MOS	0.758	0.069	1	0.752
PHKG2	0.758	0.281	-3	0.790
LATS1	0.758	0.262	-3	0.740
MNK1	0.758	0.207	-2	0.748
PKCH	0.758	0.226	2	0.646
PAK6	0.757	0.176	-2	0.677
PKCT	0.757	0.275	2	0.659
NEK7	0.757	-0.004	-3	0.623
RIPK1	0.757	0.155	1	0.833
CLK1	0.757	0.318	-3	0.841
PKCG	0.756	0.186	2	0.641
PAK2	0.756	0.211	-2	0.726
DYRK3	0.756	0.321	1	0.642
CLK2	0.756	0.334	-3	0.846
QIK	0.756	0.176	-3	0.764
PKCZ	0.755	0.177	2	0.682
RIPK3	0.755	0.054	3	0.627
TGFBR2	0.754	0.032	-2	0.708
DCAMKL2	0.754	0.305	-3	0.810
NLK	0.753	0.044	1	0.749
DSTYK	0.753	-0.039	2	0.748
DNAPK	0.753	0.104	1	0.764
ATM	0.753	0.075	1	0.727
MASTL	0.753	0.048	-2	0.754
ULK1	0.753	-0.047	-3	0.585
NEK9	0.752	0.014	2	0.718
HIPK2	0.752	0.212	1	0.527
HIPK1	0.751	0.255	1	0.624
HIPK3	0.751	0.251	1	0.662
BMPR2	0.750	-0.083	-2	0.789
IRE1	0.750	0.060	1	0.808
IRE2	0.748	0.053	2	0.706
SSTK	0.748	0.184	4	0.746
CRIK	0.748	0.435	-3	0.847
MRCKB	0.748	0.376	-3	0.824
SMMLCK	0.747	0.330	-3	0.813
PAK5	0.747	0.193	-2	0.621
IKKA	0.747	-0.018	-2	0.652
MLK2	0.746	0.017	2	0.709
MRCKA	0.746	0.353	-3	0.815
PKCI	0.746	0.200	2	0.660
ERK5	0.745	-0.038	1	0.669
NEK2	0.745	0.020	2	0.698
FAM20C	0.745	0.061	2	0.573
MARK2	0.745	0.103	4	0.661
MLK1	0.745	-0.055	2	0.701
MARK3	0.744	0.104	4	0.676
PKG1	0.744	0.295	-2	0.559
CHAK2	0.744	-0.028	-1	0.669
WNK4	0.744	0.151	-2	0.775
DYRK4	0.744	0.163	1	0.517
PAK4	0.744	0.181	-2	0.632
PKCE	0.743	0.257	2	0.629
PLK3	0.742	0.041	2	0.674
MARK1	0.742	0.118	4	0.702
ANKRD3	0.742	0.031	1	0.831
ROCK2	0.742	0.373	-3	0.809
PLK4	0.742	0.059	2	0.585
GRK4	0.741	-0.068	-2	0.780
DAPK3	0.741	0.348	-3	0.819
DYRK1B	0.740	0.179	1	0.561
TLK2	0.740	0.026	1	0.794
GRK5	0.740	-0.120	-3	0.609
PLK1	0.740	0.027	-2	0.738
TTBK2	0.738	-0.061	2	0.613
KIS	0.738	-0.017	1	0.594
BRAF	0.737	0.118	-4	0.750
GRK6	0.737	-0.044	1	0.686
PKR	0.737	0.070	1	0.819
MLK3	0.737	-0.025	2	0.646
HRI	0.737	0.004	-2	0.756
DLK	0.736	-0.027	1	0.760
ROCK1	0.736	0.368	-3	0.820
VRK2	0.735	0.040	1	0.812
GRK1	0.735	-0.011	-2	0.755
PDK1	0.735	0.320	1	0.858
MOK	0.735	0.315	1	0.638
YSK4	0.735	-0.011	1	0.795
MAK	0.735	0.292	-2	0.619
SMG1	0.735	-0.030	1	0.765
DAPK1	0.734	0.326	-3	0.829
MEK1	0.734	-0.007	2	0.744
TLK1	0.734	0.025	-2	0.731
CDK8	0.734	-0.039	1	0.556
DMPK1	0.734	0.370	-3	0.826
MPSK1	0.734	0.089	1	0.796
CHAK1	0.733	-0.039	2	0.687
CDK13	0.733	-0.012	1	0.551
CDK7	0.732	-0.009	1	0.568
PERK	0.732	0.000	-2	0.759
IRAK4	0.731	0.043	1	0.815
NEK5	0.730	0.033	1	0.837
GRK7	0.730	0.030	1	0.658
PASK	0.730	0.203	-3	0.778
JNK2	0.730	0.029	1	0.514
CDK12	0.730	0.008	1	0.529
DRAK1	0.729	0.045	1	0.693
CDK19	0.729	-0.036	1	0.517
MEKK1	0.729	-0.029	1	0.803
TGFBR1	0.728	-0.046	-2	0.684
CDK9	0.728	-0.008	1	0.562
TAO3	0.728	0.090	1	0.812
CDK18	0.728	0.006	1	0.499
JNK3	0.727	0.007	1	0.552
NEK8	0.727	0.080	2	0.716
MEK5	0.727	-0.011	2	0.730
PINK1	0.727	-0.067	1	0.790
CDK5	0.726	-0.002	1	0.581
LKB1	0.726	0.064	-3	0.622
MLK4	0.726	-0.070	2	0.632
ALK4	0.726	-0.087	-2	0.712
MST3	0.725	0.059	2	0.693
NEK4	0.725	0.058	1	0.829
CDK14	0.725	0.057	1	0.551
P38A	0.725	-0.012	1	0.599
ZAK	0.723	-0.044	1	0.749
TAO2	0.722	0.061	2	0.731
BUB1	0.722	0.125	-5	0.722
RIPK2	0.722	0.037	1	0.798
CDK10	0.722	0.077	1	0.538
MEKK3	0.722	-0.056	1	0.799
MEKK2	0.722	-0.023	2	0.719
IRAK1	0.720	-0.061	-1	0.617
PBK	0.720	0.120	1	0.720
CK1E	0.720	-0.048	-3	0.374
NEK1	0.719	0.082	1	0.825
LOK	0.718	0.081	-2	0.713
CAMKK2	0.718	-0.017	-2	0.691
CK1G1	0.718	-0.060	-3	0.339
NEK11	0.718	-0.016	1	0.809
GSK3B	0.717	0.004	4	0.419
CDK2	0.717	-0.053	1	0.574
PRP4	0.717	-0.039	-3	0.524
ALK2	0.717	-0.089	-2	0.712
TNIK	0.717	0.075	3	0.727
CDK17	0.716	-0.020	1	0.438
P38G	0.716	-0.008	1	0.426
P38B	0.716	-0.022	1	0.501
CAMKK1	0.716	-0.074	-2	0.703
GCK	0.716	0.069	1	0.785
HPK1	0.716	0.094	1	0.784
NEK3	0.716	0.057	1	0.815
KHS1	0.716	0.120	1	0.804
MEKK6	0.715	0.048	1	0.761
CDK1	0.715	-0.039	1	0.494
HGK	0.715	0.030	3	0.719
GSK3A	0.715	0.011	4	0.420
ACVR2A	0.714	-0.107	-2	0.690
BMPR1B	0.714	-0.082	1	0.553
MAP3K15	0.714	0.047	1	0.784
PLK2	0.714	0.015	-3	0.583
VRK1	0.713	0.101	2	0.765
TTBK1	0.713	-0.103	2	0.537
MINK	0.713	0.040	1	0.807
GRK2	0.712	-0.097	-2	0.647
ERK2	0.712	-0.056	1	0.576
LRRK2	0.712	0.055	2	0.732
ERK1	0.711	-0.045	1	0.517
GAK	0.711	0.027	1	0.761
ACVR2B	0.711	-0.122	-2	0.699
CDK3	0.711	-0.008	1	0.447
KHS2	0.711	0.107	1	0.800
CK1D	0.711	-0.056	-3	0.323
YSK1	0.710	0.046	2	0.693
CDK4	0.710	0.027	1	0.516
STK33	0.709	-0.055	2	0.537
TAK1	0.709	0.047	1	0.803
MST2	0.708	-0.033	1	0.786
MEK2	0.708	-0.031	2	0.736
CK1A2	0.706	-0.070	-3	0.343
ERK7	0.706	-0.034	2	0.435
CDK16	0.705	-0.024	1	0.459
SLK	0.705	-0.013	-2	0.648
MST1	0.703	-0.034	1	0.798
TAO1	0.702	0.063	1	0.807
CDK6	0.702	-0.021	1	0.545
P38D	0.702	-0.036	1	0.479
EEF2K	0.701	-0.050	3	0.699
JNK1	0.701	-0.027	1	0.485
HASPIN	0.701	0.040	-1	0.510
GRK3	0.701	-0.087	-2	0.612
CK2A2	0.700	-0.012	1	0.528
MYO3B	0.699	0.038	2	0.706
BMPR1A	0.696	-0.118	1	0.535
OSR1	0.693	-0.015	2	0.694
LIMK2_TYR	0.692	0.170	-3	0.690
BIKE	0.692	0.037	1	0.656
MYO3A	0.690	-0.006	1	0.812
ASK1	0.690	-0.011	1	0.770
PDHK3_TYR	0.690	0.078	4	0.825
TESK1_TYR	0.688	0.083	3	0.748
CK2A1	0.688	-0.030	1	0.506
PKMYT1_TYR	0.688	0.075	3	0.721
TTK	0.687	-0.016	-2	0.750
MAP2K4_TYR	0.686	0.081	-1	0.764
NEK10_TYR	0.685	0.142	1	0.782
PINK1_TYR	0.684	0.100	1	0.811
MAP2K7_TYR	0.684	-0.000	2	0.754
LIMK1_TYR	0.683	0.060	2	0.755
RET	0.683	0.079	1	0.799
MAP2K6_TYR	0.682	-0.000	-1	0.770
ALPHAK3	0.682	-0.040	-1	0.683
AAK1	0.682	0.066	1	0.563
YANK3	0.682	-0.041	2	0.319
PDHK4_TYR	0.681	-0.029	2	0.762
DDR1	0.679	0.072	4	0.778
STLK3	0.679	-0.058	1	0.765
TNNI3K_TYR	0.679	0.070	1	0.757
TYK2	0.677	-0.017	1	0.795
TNK1	0.676	0.086	3	0.643
MST1R	0.675	0.005	3	0.652
JAK1	0.674	0.062	1	0.787
ROS1	0.674	0.009	3	0.621
CK1A	0.674	-0.088	-3	0.245
PDHK1_TYR	0.673	-0.119	-1	0.747
JAK3	0.673	0.004	1	0.793
BMPR2_TYR	0.672	-0.089	-1	0.713
JAK2	0.671	-0.055	1	0.776
CSF1R	0.670	-0.026	3	0.637
TYRO3	0.670	-0.045	3	0.644
ABL2	0.669	0.004	-1	0.720
FGR	0.668	-0.044	1	0.731
EPHA6	0.668	-0.036	-1	0.697
INSRR	0.667	-0.016	3	0.583
PDGFRB	0.666	-0.042	3	0.641
WEE1_TYR	0.665	0.024	-1	0.664
PDGFRA	0.665	-0.039	3	0.643
ABL1	0.665	-0.020	-1	0.708
TNK2	0.664	-0.026	3	0.580
EPHB4	0.664	-0.060	-1	0.716
FGFR2	0.664	-0.050	3	0.627
FLT3	0.664	-0.031	3	0.633
FGFR1	0.664	-0.049	3	0.598
KDR	0.663	-0.029	3	0.593
YES1	0.661	-0.073	-1	0.688
DDR2	0.661	0.069	3	0.554
AXL	0.659	-0.044	3	0.612
PTK6	0.659	-0.076	-1	0.653
NTRK1	0.658	-0.062	-1	0.760
CK1G3	0.658	-0.098	-3	0.208
KIT	0.658	-0.091	3	0.635
LTK	0.657	-0.040	3	0.580
NTRK2	0.656	-0.075	3	0.583
ALK	0.656	-0.056	3	0.544
FLT4	0.656	-0.061	3	0.611
INSR	0.655	-0.047	3	0.576
FER	0.655	-0.163	1	0.690
EPHB3	0.653	-0.105	-1	0.713
TEK	0.653	-0.137	3	0.572
MERTK	0.653	-0.086	3	0.618
HCK	0.653	-0.136	-1	0.652
FGFR3	0.652	-0.082	3	0.594
NTRK3	0.652	-0.052	-1	0.758
LCK	0.651	-0.099	-1	0.646
MET	0.651	-0.092	3	0.614
BTK	0.651	-0.149	-1	0.620
EPHB2	0.650	-0.112	-1	0.690
FLT1	0.650	-0.103	-1	0.687
EPHB1	0.650	-0.152	1	0.677
EPHA4	0.649	-0.135	2	0.656
EPHA1	0.649	-0.072	3	0.588
ERBB2	0.649	-0.126	1	0.698
TXK	0.648	-0.100	1	0.627
EPHA3	0.648	-0.116	2	0.645
SRMS	0.647	-0.168	1	0.665
MATK	0.646	-0.061	-1	0.689
ITK	0.644	-0.160	-1	0.645
BMX	0.644	-0.090	-1	0.611
BLK	0.643	-0.104	-1	0.649
CSK	0.643	-0.081	2	0.663
MUSK	0.642	-0.062	1	0.625
EPHA7	0.641	-0.130	2	0.659
TEC	0.641	-0.158	-1	0.596
YANK2	0.640	-0.103	2	0.345
FGFR4	0.640	-0.078	-1	0.692
EPHA5	0.639	-0.106	2	0.658
IGF1R	0.639	-0.074	3	0.517
FYN	0.639	-0.105	-1	0.613
EGFR	0.638	-0.091	1	0.587
FRK	0.637	-0.160	-1	0.656
LYN	0.635	-0.160	3	0.585
PTK2B	0.635	-0.128	-1	0.652
SRC	0.632	-0.131	-1	0.634
EPHA8	0.632	-0.139	-1	0.676
CK1G2	0.624	-0.120	-3	0.277
SYK	0.620	-0.127	-1	0.628
EPHA2	0.620	-0.150	-1	0.644
PTK2	0.618	-0.140	-1	0.568
ERBB4	0.616	-0.129	1	0.527
ZAP70	0.610	-0.067	-1	0.615
FES	0.607	-0.170	-1	0.606