Motif 351 (n=111)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S1081 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A5PL33 | KRBA1 | S288 | ochoa | Protein KRBA1 | None |
| A7XYQ1 | SOBP | S629 | ochoa | Sine oculis-binding protein homolog (Jackson circler protein 1) | Implicated in development of the cochlea. {ECO:0000250|UniProtKB:Q0P5V2}. |
| A8MVW0 | FAM171A2 | S424 | ochoa | Protein FAM171A2 | None |
| A8MYA2 | CXorf49; | S28 | ochoa | Uncharacterized protein CXorf49 | None |
| H3BQZ7 | HNRNPUL2-BSCL2 | S228 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00567 | NOP56 | S563 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O15211 | RGL2 | S619 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15534 | PER1 | S980 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43683 | BUB1 | S563 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60291 | MGRN1 | S402 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| O60292 | SIPA1L3 | S1364 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60336 | MAPKBP1 | S1263 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60684 | KPNA6 | S461 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O75376 | NCOR1 | S1758 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94812 | BAIAP3 | S115 | ochoa | BAI1-associated protein 3 (BAP3) (Brain-specific angiogenesis inhibitor I-associated protein 3) | Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity). {ECO:0000250|UniProtKB:Q80TT2, ECO:0000269|PubMed:28626000}. |
| O95714 | HERC2 | S2454 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| P12956 | XRCC6 | S477 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P13010 | XRCC5 | S318 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P15104 | GLUL | S322 | psp | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) | Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:16267323, PubMed:30158707, PubMed:36289327). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351). Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (PubMed:36289327). {ECO:0000250|UniProtKB:P15105, ECO:0000269|PubMed:16267323, ECO:0000269|PubMed:18662667, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:30158707, ECO:0000269|PubMed:36289327}. |
| P15336 | ATF2 | S314 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P16157 | ANK1 | S429 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P31629 | HIVEP2 | S1937 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P31942 | HNRNPH3 | S216 | ochoa | Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) | Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. |
| P31943 | HNRNPH1 | S310 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P42684 | ABL2 | S783 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P48634 | PRRC2A | S1386 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S1525 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P52272 | HNRNPM | S432 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52272 | HNRNPM | S446 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52597 | HNRNPF | S310 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P53814 | SMTN | S792 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P55795 | HNRNPH2 | S310 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P56645 | PER3 | S923 | ochoa | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}. |
| P58753 | TIRAP | Y187 | psp | Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2) | Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6). {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286, ECO:0000269|PubMed:21829704}. |
| P67809 | YBX1 | Y208 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| Q00839 | HNRNPU | S271 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q04725 | TLE2 | S193 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
| Q0D2I5 | IFFO1 | S132 | ochoa | Non-homologous end joining factor IFFO1 (NHEJ factor IFFO1) (Intermediate filament family orphan 1) (Tumor antigen HOM-TES-103) | Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). {ECO:0000269|PubMed:31548606}. |
| Q13557 | CAMK2D | S472 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q14151 | SAFB2 | S31 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14161 | GIT2 | S514 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q15742 | NAB2 | S159 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q16825 | PTPN21 | S820 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q1KMD3 | HNRNPUL2 | S228 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q2M3G4 | SHROOM1 | S408 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q499Z4 | ZNF672 | S189 | ochoa | Zinc finger protein 672 | May be involved in transcriptional regulation. |
| Q53GL0 | PLEKHO1 | S239 | ochoa | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}. |
| Q5JSZ5 | PRRC2B | S1422 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5M775 | SPECC1 | S112 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T0N5 | FNBP1L | S489 | ochoa | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}. |
| Q5T481 | RBM20 | S742 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5T5P2 | KIAA1217 | S433 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5VT06 | CEP350 | S1551 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VZK9 | CARMIL1 | S1080 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q659A1 | ICE2 | S457 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q68CJ9 | CREB3L3 | S395 | psp | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694). {ECO:0000250, ECO:0000250|UniProtKB:Q91XE9, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704, ECO:0000269|PubMed:21666694}. |
| Q6PFW1 | PPIP5K1 | S1006 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6X4W1 | NSMF | S164 | ochoa | NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor) | Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269|PubMed:20025934}. |
| Q6Y7W6 | GIGYF2 | S236 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q6ZN55 | ZNF574 | S298 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q71H61 | ILDR2 | S547 | ochoa | Immunoglobulin-like domain-containing receptor 2 (Angulin-3) | May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}. |
| Q7Z6M1 | RABEPK | S63 | ochoa | Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) | Rab9 effector required for endosome to trans-Golgi network (TGN) transport. {ECO:0000269|PubMed:9230071}. |
| Q86SQ0 | PHLDB2 | S157 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UW7 | CADPS2 | S58 | ochoa | Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2) | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). {ECO:0000250}. |
| Q8IVL6 | P3H3 | S201 | ochoa | Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B) | Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases. {ECO:0000250|UniProtKB:Q8CG70}. |
| Q8IWU2 | LMTK2 | S1397 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8N3E9 | PLCD3 | S105 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}. |
| Q8N8Z6 | DCBLD1 | S556 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8TAD8 | SNIP1 | S99 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8WXG6 | MADD | S1059 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q92918 | MAP4K1 | S326 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q92974 | ARHGEF2 | S645 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q93100 | PHKB | S27 | ochoa | Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. |
| Q969H0 | FBXW7 | S227 | psp | F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17434132, PubMed:22748924, PubMed:26976582, PubMed:28727686, PubMed:34741373, PubMed:35395208). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:17434132, PubMed:22748924, PubMed:26774286, PubMed:26976582, PubMed:28727686, PubMed:34741373). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1 (PubMed:11565034, PubMed:11585921, PubMed:12354302, PubMed:14739463, PubMed:15103331, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:25775507, PubMed:25897075, PubMed:26976582, PubMed:28007894, PubMed:28727686, PubMed:29149593, PubMed:34102342). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (PubMed:26774286). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (PubMed:26774286). {ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000269|PubMed:34102342, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:35395208, ECO:0000305|PubMed:12354302}. |
| Q969S3 | ZNF622 | S174 | ochoa | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q96FF7 | MISP3 | S91 | ochoa | Uncharacterized protein MISP3 (MISP family member 3) | None |
| Q96FT9 | IFT43 | S78 | ochoa | Intraflagellar transport protein 43 homolog | As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (PubMed:28400947, PubMed:28973684). Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (PubMed:21378380). {ECO:0000269|PubMed:21378380, ECO:0000269|PubMed:28400947, ECO:0000269|PubMed:28973684}. |
| Q96G01 | BICD1 | S548 | ochoa | Protein bicaudal D homolog 1 (Bic-D 1) | Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. |
| Q96K83 | ZNF521 | S605 | ochoa | Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}. |
| Q96L73 | NSD1 | S2471 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96P50 | ACAP3 | S383 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (Centaurin-beta-5) (Cnt-b5) | GTPase-activating protein for the ADP ribosylation factor family. {ECO:0000305}. |
| Q96RR4 | CAMKK2 | S495 | ochoa|psp | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q96S55 | WRNIP1 | Y111 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q96T58 | SPEN | S190 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q9BW71 | HIRIP3 | S357 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BX63 | BRIP1 | S990 | ochoa|psp | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXL7 | CARD11 | S644 | ochoa|psp | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BYB0 | SHANK3 | S1577 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZ23 | PANK2 | S169 | ochoa|psp | Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)] | [Isoform 1]: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:17825826). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726). {ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:16272150, ECO:0000269|PubMed:17242360, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:30221726}.; FUNCTION: [Isoform 4]: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:16272150}. |
| Q9BZF1 | OSBPL8 | S65 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C0D7 | ZC3H12C | S232 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9H4A3 | WNK1 | S167 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H4G0 | EPB41L1 | S378 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9HB19 | PLEKHA2 | S314 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9NY61 | AATF | S143 | psp | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9P206 | NHSL3 | S138 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9UHB7 | AFF4 | S180 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHB7 | AFF4 | S212 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UIF9 | BAZ2A | S613 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UKN5 | PRDM4 | S202 | ochoa | PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) | May function as a transcription factor involved in cell differentiation. |
| Q9UPA5 | BSN | S2851 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9Y320 | TMX2 | S243 | ochoa | Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14) | Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain. {ECO:0000269|PubMed:31735293}. |
| Q9Y4B5 | MTCL1 | S1791 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y520 | PRRC2C | S1544 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9BTD8 | RBM42 | S406 | EPSD|PSP | RNA-binding protein 42 (RNA-binding motif protein 42) | Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. {ECO:0000250}. |
| P31939 | ATIC | S338 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| Q6PD62 | CTR9 | S1125 | Sugiyama | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q12913 | PTPRJ | S303 | Sugiyama | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:30591527, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}. |
| Q9UK23 | NAGPA | S145 | Sugiyama | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) | Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. {ECO:0000269|PubMed:23572527}. |
| Q9UK23 | NAGPA | S319 | Sugiyama | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) | Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. {ECO:0000269|PubMed:23572527}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.000005 | 5.311 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.000021 | 4.677 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.000138 | 3.861 |
| R-HSA-9909396 | Circadian clock | 0.000133 | 3.875 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.000212 | 3.674 |
| R-HSA-72172 | mRNA Splicing | 0.000296 | 3.528 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.000963 | 3.017 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.000963 | 3.017 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.000930 | 3.031 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.001268 | 2.897 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.001886 | 2.724 |
| R-HSA-164843 | 2-LTR circle formation | 0.004368 | 2.360 |
| R-HSA-111933 | Calmodulin induced events | 0.004237 | 2.373 |
| R-HSA-111997 | CaM pathway | 0.004237 | 2.373 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.003764 | 2.424 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.005759 | 2.240 |
| R-HSA-162592 | Integration of provirus | 0.005759 | 2.240 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.006521 | 2.186 |
| R-HSA-111996 | Ca-dependent events | 0.006416 | 2.193 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.007520 | 2.124 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.008729 | 2.059 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.009064 | 2.043 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.008729 | 2.059 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.009064 | 2.043 |
| R-HSA-73887 | Death Receptor Signaling | 0.009631 | 2.016 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.009994 | 2.000 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.014659 | 1.834 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.014659 | 1.834 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.014659 | 1.834 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.014659 | 1.834 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.014659 | 1.834 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.014117 | 1.850 |
| R-HSA-112043 | PLC beta mediated events | 0.015234 | 1.817 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.016409 | 1.785 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.017610 | 1.754 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.017610 | 1.754 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.017610 | 1.754 |
| R-HSA-112040 | G-protein mediated events | 0.018950 | 1.722 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.022396 | 1.650 |
| R-HSA-9620244 | Long-term potentiation | 0.022773 | 1.643 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.031522 | 1.501 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.028572 | 1.544 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.036317 | 1.440 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.035560 | 1.449 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.034689 | 1.460 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.034689 | 1.460 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.034689 | 1.460 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.043735 | 1.359 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.057888 | 1.237 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.057888 | 1.237 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.071833 | 1.144 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.144949 | 0.839 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.163879 | 0.785 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.170096 | 0.769 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.170096 | 0.769 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.170096 | 0.769 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.170096 | 0.769 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.176267 | 0.754 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.176267 | 0.754 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.182393 | 0.739 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.074319 | 1.129 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.206447 | 0.685 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.218210 | 0.661 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.229800 | 0.639 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.155669 | 0.808 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.155669 | 0.808 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.295845 | 0.529 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.295845 | 0.529 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.200789 | 0.697 |
| R-HSA-4641265 | Repression of WNT target genes | 0.112451 | 0.949 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.046676 | 1.331 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.144949 | 0.839 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.252471 | 0.598 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.076456 | 1.117 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.258034 | 0.588 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.142809 | 0.845 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.252471 | 0.598 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.241708 | 0.617 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.263556 | 0.579 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.085573 | 1.068 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.188474 | 0.725 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.224026 | 0.650 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.263556 | 0.579 |
| R-HSA-5693538 | Homology Directed Repair | 0.258206 | 0.588 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.039685 | 1.401 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.235531 | 0.628 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.189236 | 0.723 |
| R-HSA-447043 | Neurofascin interactions | 0.064886 | 1.188 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.085573 | 1.068 |
| R-HSA-9707616 | Heme signaling | 0.096513 | 1.015 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.285242 | 0.545 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.125228 | 0.902 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.078728 | 1.104 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.078728 | 1.104 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.099111 | 1.004 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.105806 | 0.975 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.157616 | 0.802 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.052214 | 1.282 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.224026 | 0.650 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.074319 | 1.129 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.053038 | 1.275 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.266464 | 0.574 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.078728 | 1.104 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.082981 | 1.081 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.218210 | 0.661 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.110620 | 0.956 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.269038 | 0.570 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.279880 | 0.553 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.252471 | 0.598 |
| R-HSA-202403 | TCR signaling | 0.230738 | 0.637 |
| R-HSA-447038 | NrCAM interactions | 0.050838 | 1.294 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.200500 | 0.698 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.125228 | 0.902 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.260959 | 0.583 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.260959 | 0.583 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.269217 | 0.570 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.269217 | 0.570 |
| R-HSA-9659379 | Sensory processing of sound | 0.137732 | 0.861 |
| R-HSA-5260271 | Diseases of Immune System | 0.295845 | 0.529 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.295845 | 0.529 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.096139 | 1.017 |
| R-HSA-447041 | CHL1 interactions | 0.071833 | 1.144 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.112451 | 0.949 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.112451 | 0.949 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.112451 | 0.949 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.228000 | 0.642 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.064886 | 1.188 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.206447 | 0.685 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.153079 | 0.815 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.295845 | 0.529 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.144949 | 0.839 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.048497 | 1.314 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.114276 | 0.942 |
| R-HSA-196783 | Coenzyme A biosynthesis | 0.144949 | 0.839 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.154513 | 0.811 |
| R-HSA-112316 | Neuronal System | 0.159040 | 0.798 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.188474 | 0.725 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.194509 | 0.711 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.206447 | 0.685 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.229800 | 0.639 |
| R-HSA-69481 | G2/M Checkpoints | 0.285728 | 0.544 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.122761 | 0.911 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.091944 | 1.036 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.246866 | 0.608 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.049700 | 1.304 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.082981 | 1.081 |
| R-HSA-8953854 | Metabolism of RNA | 0.189057 | 0.723 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.184382 | 0.734 |
| R-HSA-111885 | Opioid Signalling | 0.055322 | 1.257 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.170096 | 0.769 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.224026 | 0.650 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.252471 | 0.598 |
| R-HSA-5673000 | RAF activation | 0.263556 | 0.579 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.279880 | 0.553 |
| R-HSA-8982491 | Glycogen metabolism | 0.295845 | 0.529 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.258034 | 0.588 |
| R-HSA-166520 | Signaling by NTRKs | 0.127759 | 0.894 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.258034 | 0.588 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.258034 | 0.588 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.274479 | 0.561 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.284614 | 0.546 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.160874 | 0.794 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.125228 | 0.902 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.192703 | 0.715 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.294103 | 0.531 |
| R-HSA-9607240 | FLT3 Signaling | 0.050343 | 1.298 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.052214 | 1.282 |
| R-HSA-157118 | Signaling by NOTCH | 0.045774 | 1.339 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.236219 | 0.627 |
| R-HSA-8853659 | RET signaling | 0.274479 | 0.561 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.115437 | 0.938 |
| R-HSA-391251 | Protein folding | 0.176672 | 0.753 |
| R-HSA-162582 | Signal Transduction | 0.133683 | 0.874 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.142809 | 0.845 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.101981 | 0.991 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.103500 | 0.985 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.255454 | 0.593 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.171378 | 0.766 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.061928 | 1.208 |
| R-HSA-190236 | Signaling by FGFR | 0.048611 | 1.313 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.130196 | 0.885 |
| R-HSA-75893 | TNF signaling | 0.082981 | 1.081 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.160874 | 0.794 |
| R-HSA-9843745 | Adipogenesis | 0.299462 | 0.524 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.301089 | 0.521 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.301089 | 0.521 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.306293 | 0.514 |
| R-HSA-73894 | DNA Repair | 0.314677 | 0.502 |
| R-HSA-4839726 | Chromatin organization | 0.324572 | 0.489 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.331745 | 0.479 |
| R-HSA-9675135 | Diseases of DNA repair | 0.331745 | 0.479 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.331745 | 0.479 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.331745 | 0.479 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.331745 | 0.479 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.331745 | 0.479 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.336723 | 0.473 |
| R-HSA-5620924 | Intraflagellar transport | 0.341665 | 0.466 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.341665 | 0.466 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.351155 | 0.455 |
| R-HSA-9758941 | Gastrulation | 0.353845 | 0.451 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.356271 | 0.448 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.356271 | 0.448 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.361068 | 0.442 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.361068 | 0.442 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.365829 | 0.437 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.365829 | 0.437 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.370009 | 0.432 |
| R-HSA-162587 | HIV Life Cycle | 0.375217 | 0.426 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.375247 | 0.426 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.375247 | 0.426 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.375247 | 0.426 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.375247 | 0.426 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.379903 | 0.420 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.379903 | 0.420 |
| R-HSA-5578775 | Ion homeostasis | 0.379903 | 0.420 |
| R-HSA-877300 | Interferon gamma signaling | 0.380517 | 0.420 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.383160 | 0.417 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.389114 | 0.410 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.389114 | 0.410 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.393668 | 0.405 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.393684 | 0.405 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.398188 | 0.400 |
| R-HSA-450294 | MAP kinase activation | 0.402675 | 0.395 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.405444 | 0.392 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.407129 | 0.390 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.407129 | 0.390 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.411550 | 0.386 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.415939 | 0.381 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.419372 | 0.377 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.420294 | 0.376 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.428910 | 0.368 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.428910 | 0.368 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.433169 | 0.363 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.441595 | 0.355 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.441595 | 0.355 |
| R-HSA-448424 | Interleukin-17 signaling | 0.441595 | 0.355 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.445761 | 0.351 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.445761 | 0.351 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.445761 | 0.351 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.458075 | 0.339 |
| R-HSA-983712 | Ion channel transport | 0.459951 | 0.337 |
| R-HSA-8852135 | Protein ubiquitination | 0.462119 | 0.335 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.464878 | 0.333 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.466249 | 0.331 |
| R-HSA-68877 | Mitotic Prometaphase | 0.469779 | 0.328 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.470118 | 0.328 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.474072 | 0.324 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.474072 | 0.324 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.474072 | 0.324 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.481895 | 0.317 |
| R-HSA-6806834 | Signaling by MET | 0.481895 | 0.317 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.486723 | 0.313 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.493412 | 0.307 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.500949 | 0.300 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.504676 | 0.297 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.508375 | 0.294 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.508375 | 0.294 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.516941 | 0.287 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.519309 | 0.285 |
| R-HSA-202424 | Downstream TCR signaling | 0.522899 | 0.282 |
| R-HSA-68882 | Mitotic Anaphase | 0.526453 | 0.279 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.528726 | 0.277 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.533513 | 0.273 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.536998 | 0.270 |
| R-HSA-1474290 | Collagen formation | 0.540458 | 0.267 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.550684 | 0.259 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.550684 | 0.259 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.550684 | 0.259 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.550684 | 0.259 |
| R-HSA-162906 | HIV Infection | 0.551047 | 0.259 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.557375 | 0.254 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.557375 | 0.254 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.557375 | 0.254 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.557375 | 0.254 |
| R-HSA-199991 | Membrane Trafficking | 0.560629 | 0.251 |
| R-HSA-3214847 | HATs acetylate histones | 0.560684 | 0.251 |
| R-HSA-1483255 | PI Metabolism | 0.570463 | 0.244 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.573675 | 0.241 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.576862 | 0.239 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.580027 | 0.237 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.580027 | 0.237 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.583167 | 0.234 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.589379 | 0.230 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.589379 | 0.230 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.592450 | 0.227 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.592450 | 0.227 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.592450 | 0.227 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.595499 | 0.225 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.595499 | 0.225 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.595499 | 0.225 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.598525 | 0.223 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.598525 | 0.223 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.607468 | 0.216 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.616214 | 0.210 |
| R-HSA-418594 | G alpha (i) signalling events | 0.621253 | 0.207 |
| R-HSA-373760 | L1CAM interactions | 0.621937 | 0.206 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.624767 | 0.204 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.630364 | 0.200 |
| R-HSA-3371556 | Cellular response to heat stress | 0.635877 | 0.197 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.649307 | 0.188 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.649307 | 0.188 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.649307 | 0.188 |
| R-HSA-9675108 | Nervous system development | 0.661442 | 0.180 |
| R-HSA-5576891 | Cardiac conduction | 0.667288 | 0.176 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.669781 | 0.174 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.681971 | 0.166 |
| R-HSA-1483257 | Phospholipid metabolism | 0.682912 | 0.166 |
| R-HSA-5368287 | Mitochondrial translation | 0.686720 | 0.163 |
| R-HSA-1280218 | Adaptive Immune System | 0.688937 | 0.162 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.689069 | 0.162 |
| R-HSA-6807070 | PTEN Regulation | 0.689069 | 0.162 |
| R-HSA-6798695 | Neutrophil degranulation | 0.694716 | 0.158 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.700552 | 0.155 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.702798 | 0.153 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.709435 | 0.149 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.714702 | 0.146 |
| R-HSA-69306 | DNA Replication | 0.722271 | 0.141 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.724355 | 0.140 |
| R-HSA-1989781 | PPARA activates gene expression | 0.726424 | 0.139 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.727329 | 0.138 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.730515 | 0.136 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.732538 | 0.135 |
| R-HSA-9711097 | Cellular response to starvation | 0.732538 | 0.135 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.736538 | 0.133 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.745268 | 0.128 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.757502 | 0.121 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.759324 | 0.120 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.766476 | 0.116 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.780155 | 0.108 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.781636 | 0.107 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.788297 | 0.103 |
| R-HSA-5617833 | Cilium Assembly | 0.791469 | 0.102 |
| R-HSA-1640170 | Cell Cycle | 0.797089 | 0.098 |
| R-HSA-422475 | Axon guidance | 0.797288 | 0.098 |
| R-HSA-9609690 | HCMV Early Events | 0.800707 | 0.097 |
| R-HSA-68886 | M Phase | 0.805092 | 0.094 |
| R-HSA-913531 | Interferon Signaling | 0.806204 | 0.094 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.809538 | 0.092 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.810972 | 0.091 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.810972 | 0.091 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.810972 | 0.091 |
| R-HSA-397014 | Muscle contraction | 0.824733 | 0.084 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.834043 | 0.079 |
| R-HSA-8951664 | Neddylation | 0.836266 | 0.078 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.847046 | 0.072 |
| R-HSA-388396 | GPCR downstream signalling | 0.848713 | 0.071 |
| R-HSA-72312 | rRNA processing | 0.849345 | 0.071 |
| R-HSA-15869 | Metabolism of nucleotides | 0.853839 | 0.069 |
| R-HSA-8939211 | ESR-mediated signaling | 0.854942 | 0.068 |
| R-HSA-449147 | Signaling by Interleukins | 0.864148 | 0.063 |
| R-HSA-9609646 | HCMV Infection | 0.868547 | 0.061 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.880281 | 0.055 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.885320 | 0.053 |
| R-HSA-74160 | Gene expression (Transcription) | 0.888950 | 0.051 |
| R-HSA-372790 | Signaling by GPCR | 0.897633 | 0.047 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.906580 | 0.043 |
| R-HSA-195721 | Signaling by WNT | 0.908686 | 0.042 |
| R-HSA-1474244 | Extracellular matrix organization | 0.928966 | 0.032 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.935694 | 0.029 |
| R-HSA-168256 | Immune System | 0.941129 | 0.026 |
| R-HSA-168249 | Innate Immune System | 0.942974 | 0.026 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.944770 | 0.025 |
| R-HSA-212436 | Generic Transcription Pathway | 0.954736 | 0.020 |
| R-HSA-2262752 | Cellular responses to stress | 0.954751 | 0.020 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.964828 | 0.016 |
| R-HSA-72766 | Translation | 0.966665 | 0.015 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.972694 | 0.012 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.977317 | 0.010 |
| R-HSA-382551 | Transport of small molecules | 0.981877 | 0.008 |
| R-HSA-1266738 | Developmental Biology | 0.983759 | 0.007 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.992241 | 0.003 |
| R-HSA-9824446 | Viral Infection Pathways | 0.992690 | 0.003 |
| R-HSA-109582 | Hemostasis | 0.997875 | 0.001 |
| R-HSA-597592 | Post-translational protein modification | 0.998994 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999331 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999356 | 0.000 |
| R-HSA-1643685 | Disease | 0.999615 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999839 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999869 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999996 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
SRPK2 |
0.816 | 0.702 | -3 | 0.800 |
SRPK1 |
0.813 | 0.697 | -3 | 0.737 |
SRPK3 |
0.797 | 0.647 | -3 | 0.732 |
HIPK2 |
0.793 | 0.580 | 1 | 0.872 |
CLK1 |
0.792 | 0.623 | -3 | 0.690 |
DYRK1A |
0.791 | 0.661 | 1 | 0.900 |
CDKL5 |
0.790 | 0.607 | -3 | 0.680 |
HIPK4 |
0.787 | 0.567 | 1 | 0.816 |
HIPK1 |
0.785 | 0.613 | 1 | 0.888 |
CLK2 |
0.785 | 0.583 | -3 | 0.720 |
CLK4 |
0.783 | 0.592 | -3 | 0.685 |
CDKL1 |
0.782 | 0.682 | -3 | 0.656 |
HIPK3 |
0.780 | 0.610 | 1 | 0.877 |
DYRK2 |
0.780 | 0.549 | 1 | 0.885 |
MAK |
0.780 | 0.598 | -2 | 0.639 |
AKT3 |
0.779 | 0.602 | -3 | 0.825 |
AKT2 |
0.778 | 0.600 | -3 | 0.772 |
SBK |
0.777 | 0.688 | -3 | 0.844 |
DYRK3 |
0.777 | 0.590 | 1 | 0.868 |
DYRK1B |
0.776 | 0.541 | 1 | 0.888 |
PRKD2 |
0.775 | 0.512 | -3 | 0.661 |
RSK3 |
0.775 | 0.548 | -3 | 0.699 |
RSK2 |
0.774 | 0.548 | -3 | 0.704 |
ICK |
0.774 | 0.616 | -3 | 0.596 |
SGK1 |
0.772 | 0.610 | -3 | 0.830 |
P90RSK |
0.772 | 0.578 | -3 | 0.705 |
PRKD3 |
0.771 | 0.562 | -3 | 0.692 |
CLK3 |
0.770 | 0.417 | 1 | 0.848 |
PIM1 |
0.770 | 0.552 | -3 | 0.666 |
MOK |
0.768 | 0.606 | 1 | 0.826 |
KIS |
0.768 | 0.322 | 1 | 0.910 |
CDK10 |
0.768 | 0.447 | 1 | 0.893 |
RSK4 |
0.767 | 0.521 | -3 | 0.732 |
PIM3 |
0.767 | 0.495 | -3 | 0.582 |
DYRK4 |
0.766 | 0.494 | 1 | 0.893 |
PIM2 |
0.766 | 0.564 | -3 | 0.712 |
MAPKAPK2 |
0.766 | 0.521 | -3 | 0.704 |
PRKX |
0.766 | 0.444 | -3 | 0.721 |
MAPKAPK3 |
0.765 | 0.519 | -3 | 0.625 |
AKT1 |
0.765 | 0.523 | -3 | 0.737 |
NDR2 |
0.764 | 0.355 | -3 | 0.517 |
CDK7 |
0.763 | 0.359 | 1 | 0.912 |
PKACB |
0.762 | 0.411 | -2 | 0.570 |
PKACA |
0.762 | 0.431 | -2 | 0.529 |
CDK19 |
0.762 | 0.313 | 1 | 0.896 |
SGK3 |
0.762 | 0.495 | -3 | 0.648 |
PRKD1 |
0.761 | 0.412 | -3 | 0.569 |
MSK2 |
0.759 | 0.506 | -3 | 0.715 |
PKACG |
0.759 | 0.358 | -2 | 0.653 |
SIK |
0.759 | 0.444 | -3 | 0.624 |
CDK18 |
0.759 | 0.333 | 1 | 0.887 |
P70S6KB |
0.758 | 0.487 | -3 | 0.633 |
NUAK2 |
0.758 | 0.447 | -3 | 0.558 |
NDR1 |
0.758 | 0.400 | -3 | 0.544 |
NLK |
0.758 | 0.388 | 1 | 0.869 |
PKN3 |
0.758 | 0.438 | -3 | 0.556 |
CDK14 |
0.757 | 0.414 | 1 | 0.895 |
CDK8 |
0.757 | 0.298 | 1 | 0.902 |
NUAK1 |
0.757 | 0.428 | -3 | 0.612 |
AMPKA2 |
0.756 | 0.404 | -3 | 0.564 |
CHK2 |
0.756 | 0.609 | -3 | 0.782 |
CDK9 |
0.755 | 0.347 | 1 | 0.911 |
MSK1 |
0.754 | 0.447 | -3 | 0.701 |
P70S6K |
0.754 | 0.520 | -3 | 0.726 |
PKG2 |
0.753 | 0.323 | -2 | 0.582 |
CDK12 |
0.753 | 0.350 | 1 | 0.899 |
MELK |
0.753 | 0.441 | -3 | 0.576 |
AMPKA1 |
0.752 | 0.352 | -3 | 0.505 |
MAPKAPK5 |
0.752 | 0.534 | -3 | 0.684 |
CAMK1B |
0.752 | 0.493 | -3 | 0.513 |
AURC |
0.752 | 0.220 | -2 | 0.547 |
CAMK1D |
0.751 | 0.541 | -3 | 0.728 |
CDK17 |
0.751 | 0.327 | 1 | 0.865 |
CDK13 |
0.751 | 0.322 | 1 | 0.905 |
CAMK1A |
0.750 | 0.549 | -3 | 0.760 |
PKN1 |
0.750 | 0.494 | -3 | 0.697 |
LATS2 |
0.750 | 0.287 | -5 | 0.799 |
CDK5 |
0.749 | 0.308 | 1 | 0.904 |
JNK2 |
0.749 | 0.352 | 1 | 0.902 |
CAMK1G |
0.748 | 0.474 | -3 | 0.664 |
QSK |
0.748 | 0.319 | 4 | 0.571 |
PKN2 |
0.748 | 0.345 | -3 | 0.494 |
PHKG1 |
0.745 | 0.338 | -3 | 0.534 |
BRSK1 |
0.745 | 0.371 | -3 | 0.607 |
PKCD |
0.744 | 0.315 | 2 | 0.785 |
MYLK4 |
0.744 | 0.380 | -2 | 0.662 |
P38G |
0.744 | 0.327 | 1 | 0.869 |
DCAMKL1 |
0.744 | 0.468 | -3 | 0.607 |
TSSK1 |
0.744 | 0.277 | -3 | 0.490 |
CDK1 |
0.744 | 0.304 | 1 | 0.891 |
CDK4 |
0.744 | 0.382 | 1 | 0.892 |
DAPK2 |
0.742 | 0.436 | -3 | 0.482 |
P38A |
0.742 | 0.309 | 1 | 0.898 |
CAMLCK |
0.742 | 0.373 | -2 | 0.716 |
CAMK4 |
0.742 | 0.337 | -3 | 0.517 |
ERK1 |
0.741 | 0.299 | 1 | 0.895 |
CDC7 |
0.741 | 0.076 | 1 | 0.680 |
CAMK2D |
0.740 | 0.312 | -3 | 0.490 |
ERK5 |
0.740 | 0.159 | 1 | 0.801 |
SKMLCK |
0.740 | 0.303 | -2 | 0.743 |
MTOR |
0.740 | 0.098 | 1 | 0.731 |
WNK1 |
0.740 | 0.197 | -2 | 0.760 |
BRSK2 |
0.739 | 0.276 | -3 | 0.528 |
CDK16 |
0.739 | 0.305 | 1 | 0.869 |
MRCKB |
0.739 | 0.463 | -3 | 0.676 |
COT |
0.739 | 0.053 | 2 | 0.858 |
CDK3 |
0.739 | 0.280 | 1 | 0.875 |
PKG1 |
0.738 | 0.371 | -2 | 0.504 |
MARK4 |
0.738 | 0.158 | 4 | 0.570 |
QIK |
0.738 | 0.263 | -3 | 0.468 |
P38B |
0.738 | 0.301 | 1 | 0.891 |
PKCB |
0.738 | 0.279 | 2 | 0.727 |
JNK3 |
0.738 | 0.322 | 1 | 0.910 |
AURB |
0.738 | 0.195 | -2 | 0.542 |
CDK6 |
0.738 | 0.327 | 1 | 0.895 |
NIK |
0.737 | 0.380 | -3 | 0.405 |
CRIK |
0.737 | 0.533 | -3 | 0.762 |
PAK1 |
0.737 | 0.240 | -2 | 0.660 |
NIM1 |
0.736 | 0.231 | 3 | 0.714 |
PAK3 |
0.736 | 0.224 | -2 | 0.660 |
PKCA |
0.736 | 0.236 | 2 | 0.725 |
MNK2 |
0.736 | 0.180 | -2 | 0.655 |
PKCG |
0.736 | 0.250 | 2 | 0.725 |
MOS |
0.735 | 0.123 | 1 | 0.713 |
MST4 |
0.734 | 0.134 | 2 | 0.824 |
PAK6 |
0.734 | 0.176 | -2 | 0.578 |
MNK1 |
0.734 | 0.209 | -2 | 0.666 |
CAMK2A |
0.734 | 0.323 | 2 | 0.737 |
CHK1 |
0.733 | 0.298 | -3 | 0.480 |
DCAMKL2 |
0.732 | 0.365 | -3 | 0.576 |
ERK2 |
0.732 | 0.293 | 1 | 0.895 |
PKCH |
0.732 | 0.263 | 2 | 0.727 |
PKCT |
0.732 | 0.311 | 2 | 0.739 |
LATS1 |
0.732 | 0.289 | -3 | 0.482 |
PKCE |
0.731 | 0.338 | 2 | 0.714 |
PHKG2 |
0.731 | 0.287 | -3 | 0.543 |
MRCKA |
0.731 | 0.428 | -3 | 0.646 |
ATR |
0.730 | 0.063 | 1 | 0.664 |
PRPK |
0.729 | -0.036 | -1 | 0.789 |
MARK3 |
0.729 | 0.170 | 4 | 0.518 |
SMMLCK |
0.729 | 0.416 | -3 | 0.582 |
CDK2 |
0.728 | 0.214 | 1 | 0.877 |
TGFBR2 |
0.728 | 0.070 | -2 | 0.662 |
TSSK2 |
0.728 | 0.184 | -5 | 0.870 |
P38D |
0.728 | 0.288 | 1 | 0.888 |
MARK2 |
0.727 | 0.156 | 4 | 0.508 |
RAF1 |
0.727 | 0.060 | 1 | 0.659 |
ROCK2 |
0.727 | 0.429 | -3 | 0.611 |
IKKB |
0.727 | 0.012 | -2 | 0.679 |
DMPK1 |
0.727 | 0.454 | -3 | 0.653 |
PAK2 |
0.727 | 0.209 | -2 | 0.644 |
PDHK4 |
0.727 | -0.095 | 1 | 0.701 |
PKCZ |
0.727 | 0.197 | 2 | 0.783 |
CAMK2B |
0.727 | 0.250 | 2 | 0.745 |
DAPK3 |
0.726 | 0.409 | -3 | 0.619 |
TBK1 |
0.726 | -0.054 | 1 | 0.585 |
PRP4 |
0.726 | 0.143 | -3 | 0.206 |
DAPK1 |
0.725 | 0.411 | -3 | 0.648 |
PAK5 |
0.724 | 0.201 | -2 | 0.524 |
MARK1 |
0.724 | 0.185 | 4 | 0.534 |
GCN2 |
0.724 | -0.092 | 2 | 0.795 |
IRE1 |
0.724 | 0.065 | 1 | 0.592 |
WNK3 |
0.723 | 0.027 | 1 | 0.628 |
PKCI |
0.723 | 0.242 | 2 | 0.748 |
SNRK |
0.722 | 0.226 | 2 | 0.705 |
MASTL |
0.722 | 0.050 | -2 | 0.714 |
ULK2 |
0.721 | -0.104 | 2 | 0.814 |
AURA |
0.720 | 0.153 | -2 | 0.506 |
IKKE |
0.720 | -0.076 | 1 | 0.582 |
RIPK1 |
0.720 | 0.119 | 1 | 0.614 |
RIPK3 |
0.720 | 0.012 | 3 | 0.688 |
PDHK1 |
0.720 | -0.105 | 1 | 0.681 |
ROCK1 |
0.720 | 0.419 | -3 | 0.649 |
BMPR2 |
0.719 | -0.114 | -2 | 0.745 |
PAK4 |
0.719 | 0.191 | -2 | 0.522 |
CHAK2 |
0.718 | -0.011 | -1 | 0.779 |
CK1E |
0.717 | -0.013 | -3 | 0.115 |
SSTK |
0.717 | 0.148 | 4 | 0.566 |
GRK1 |
0.716 | 0.023 | -2 | 0.780 |
CAMK2G |
0.716 | -0.059 | 2 | 0.780 |
BCKDK |
0.716 | -0.062 | -1 | 0.724 |
JNK1 |
0.715 | 0.275 | 1 | 0.892 |
IRE2 |
0.714 | 0.042 | 2 | 0.786 |
HUNK |
0.714 | -0.036 | 2 | 0.796 |
DSTYK |
0.713 | -0.104 | 2 | 0.844 |
GRK5 |
0.713 | -0.076 | -3 | 0.241 |
WNK4 |
0.713 | 0.150 | -2 | 0.743 |
PASK |
0.713 | 0.335 | -3 | 0.519 |
CK1D |
0.713 | -0.005 | -3 | 0.089 |
NEK6 |
0.712 | -0.094 | -2 | 0.710 |
ULK1 |
0.712 | -0.130 | -3 | 0.206 |
MLK2 |
0.712 | -0.030 | 2 | 0.819 |
MPSK1 |
0.711 | 0.096 | 1 | 0.625 |
NEK7 |
0.710 | -0.146 | -3 | 0.226 |
TTBK2 |
0.710 | -0.038 | 2 | 0.726 |
PDK1 |
0.709 | 0.312 | 1 | 0.650 |
MLK1 |
0.708 | -0.099 | 2 | 0.803 |
DLK |
0.708 | 0.025 | 1 | 0.646 |
NEK9 |
0.708 | -0.120 | 2 | 0.839 |
CK1A2 |
0.707 | -0.026 | -3 | 0.109 |
IKKA |
0.707 | -0.086 | -2 | 0.674 |
ANKRD3 |
0.707 | -0.001 | 1 | 0.665 |
PKR |
0.707 | 0.031 | 1 | 0.647 |
NEK2 |
0.706 | -0.062 | 2 | 0.811 |
ATM |
0.706 | -0.006 | 1 | 0.608 |
ALK4 |
0.705 | -0.012 | -2 | 0.717 |
GRK7 |
0.705 | 0.052 | 1 | 0.615 |
IRAK4 |
0.705 | 0.041 | 1 | 0.599 |
VRK2 |
0.704 | 0.011 | 1 | 0.721 |
CK1G1 |
0.704 | -0.049 | -3 | 0.103 |
MEK1 |
0.704 | -0.010 | 2 | 0.829 |
GRK6 |
0.703 | -0.059 | 1 | 0.644 |
PINK1 |
0.703 | 0.010 | 1 | 0.734 |
CHAK1 |
0.703 | -0.041 | 2 | 0.793 |
MLK3 |
0.703 | -0.031 | 2 | 0.731 |
SMG1 |
0.702 | -0.053 | 1 | 0.622 |
PBK |
0.702 | 0.137 | 1 | 0.625 |
ERK7 |
0.701 | 0.096 | 2 | 0.524 |
DNAPK |
0.701 | -0.006 | 1 | 0.590 |
BMPR1B |
0.700 | -0.010 | 1 | 0.618 |
DRAK1 |
0.700 | 0.061 | 1 | 0.588 |
MST3 |
0.699 | 0.068 | 2 | 0.799 |
GRK4 |
0.699 | -0.096 | -2 | 0.753 |
TGFBR1 |
0.698 | -0.038 | -2 | 0.701 |
GSK3A |
0.698 | 0.039 | 4 | 0.237 |
PLK4 |
0.697 | -0.018 | 2 | 0.657 |
YSK4 |
0.697 | -0.071 | 1 | 0.606 |
BUB1 |
0.697 | 0.125 | -5 | 0.782 |
MEK5 |
0.697 | 0.026 | 2 | 0.826 |
PERK |
0.696 | -0.041 | -2 | 0.714 |
GSK3B |
0.696 | -0.005 | 4 | 0.238 |
TAO3 |
0.696 | 0.070 | 1 | 0.642 |
FAM20C |
0.695 | 0.000 | 2 | 0.637 |
LOK |
0.695 | 0.124 | -2 | 0.675 |
GRK2 |
0.694 | -0.034 | -2 | 0.668 |
IRAK1 |
0.694 | -0.027 | -1 | 0.726 |
BRAF |
0.693 | 0.033 | -4 | 0.773 |
HRI |
0.692 | -0.089 | -2 | 0.708 |
PLK1 |
0.692 | -0.096 | -2 | 0.645 |
TAO2 |
0.692 | 0.055 | 2 | 0.836 |
HPK1 |
0.691 | 0.120 | 1 | 0.624 |
NEK5 |
0.690 | -0.069 | 1 | 0.629 |
LRRK2 |
0.690 | 0.147 | 2 | 0.837 |
LKB1 |
0.690 | 0.010 | -3 | 0.244 |
MLK4 |
0.690 | -0.079 | 2 | 0.726 |
NEK11 |
0.690 | -0.015 | 1 | 0.631 |
MEKK6 |
0.690 | 0.061 | 1 | 0.617 |
ZAK |
0.690 | -0.061 | 1 | 0.606 |
ALK2 |
0.690 | -0.052 | -2 | 0.712 |
ACVR2A |
0.689 | -0.073 | -2 | 0.653 |
KHS2 |
0.689 | 0.146 | 1 | 0.629 |
TLK2 |
0.689 | -0.078 | 1 | 0.589 |
KHS1 |
0.689 | 0.117 | 1 | 0.618 |
HASPIN |
0.688 | 0.121 | -1 | 0.678 |
MEKK2 |
0.688 | -0.030 | 2 | 0.814 |
MEKK1 |
0.688 | -0.110 | 1 | 0.630 |
ACVR2B |
0.687 | -0.088 | -2 | 0.677 |
HGK |
0.687 | 0.043 | 3 | 0.858 |
GCK |
0.687 | 0.067 | 1 | 0.629 |
TTBK1 |
0.687 | -0.064 | 2 | 0.651 |
TNIK |
0.687 | 0.072 | 3 | 0.851 |
MAP3K15 |
0.686 | 0.019 | 1 | 0.607 |
TLK1 |
0.686 | -0.057 | -2 | 0.724 |
GAK |
0.685 | 0.036 | 1 | 0.678 |
SLK |
0.685 | 0.056 | -2 | 0.643 |
MEKK3 |
0.685 | -0.070 | 1 | 0.629 |
CAMKK2 |
0.684 | -0.041 | -2 | 0.656 |
GRK3 |
0.684 | -0.038 | -2 | 0.646 |
NEK8 |
0.683 | 0.028 | 2 | 0.818 |
NEK4 |
0.683 | -0.041 | 1 | 0.607 |
NEK3 |
0.683 | 0.002 | 1 | 0.604 |
MINK |
0.682 | 0.008 | 1 | 0.613 |
BMPR1A |
0.679 | -0.055 | 1 | 0.606 |
YSK1 |
0.679 | 0.028 | 2 | 0.805 |
STK33 |
0.679 | -0.005 | 2 | 0.634 |
PLK3 |
0.679 | -0.147 | 2 | 0.749 |
LIMK2_TYR |
0.678 | 0.219 | -3 | 0.331 |
NEK1 |
0.677 | -0.049 | 1 | 0.606 |
CAMKK1 |
0.677 | -0.137 | -2 | 0.656 |
EEF2K |
0.677 | -0.016 | 3 | 0.826 |
RIPK2 |
0.676 | -0.022 | 1 | 0.581 |
MST2 |
0.673 | -0.101 | 1 | 0.630 |
CK1A |
0.673 | -0.049 | -3 | 0.051 |
PKMYT1_TYR |
0.672 | 0.119 | 3 | 0.804 |
MST1 |
0.671 | -0.063 | 1 | 0.613 |
MEK2 |
0.671 | -0.106 | 2 | 0.819 |
TAK1 |
0.671 | 0.003 | 1 | 0.622 |
TESK1_TYR |
0.670 | 0.142 | 3 | 0.838 |
PDHK3_TYR |
0.668 | 0.035 | 4 | 0.596 |
VRK1 |
0.668 | -0.081 | 2 | 0.837 |
TAO1 |
0.667 | 0.034 | 1 | 0.580 |
MAP2K4_TYR |
0.666 | 0.132 | -1 | 0.789 |
BIKE |
0.666 | 0.011 | 1 | 0.595 |
MYO3B |
0.665 | 0.011 | 2 | 0.819 |
LIMK1_TYR |
0.665 | 0.067 | 2 | 0.857 |
PINK1_TYR |
0.663 | 0.110 | 1 | 0.675 |
CK2A2 |
0.662 | -0.064 | 1 | 0.574 |
MAP2K7_TYR |
0.662 | 0.004 | 2 | 0.843 |
YANK3 |
0.662 | 0.007 | 2 | 0.410 |
OSR1 |
0.659 | -0.045 | 2 | 0.805 |
TNK2 |
0.658 | 0.057 | 3 | 0.729 |
AAK1 |
0.658 | 0.030 | 1 | 0.532 |
BMPR2_TYR |
0.657 | -0.015 | -1 | 0.763 |
TNK1 |
0.657 | 0.070 | 3 | 0.752 |
MAP2K6_TYR |
0.657 | -0.004 | -1 | 0.781 |
MYO3A |
0.657 | -0.020 | 1 | 0.603 |
ASK1 |
0.656 | -0.049 | 1 | 0.601 |
RET |
0.656 | -0.010 | 1 | 0.636 |
PDHK4_TYR |
0.656 | -0.057 | 2 | 0.847 |
TNNI3K_TYR |
0.655 | 0.033 | 1 | 0.646 |
TTK |
0.655 | -0.052 | -2 | 0.670 |
DDR1 |
0.654 | -0.006 | 4 | 0.533 |
MST1R |
0.653 | -0.022 | 3 | 0.787 |
PDHK1_TYR |
0.653 | -0.059 | -1 | 0.780 |
ROS1 |
0.653 | -0.047 | 3 | 0.743 |
PLK2 |
0.653 | -0.125 | -3 | 0.163 |
TYRO3 |
0.653 | -0.057 | 3 | 0.780 |
CK2A1 |
0.653 | -0.072 | 1 | 0.557 |
NEK10_TYR |
0.652 | 0.035 | 1 | 0.552 |
EPHA6 |
0.650 | -0.023 | -1 | 0.731 |
TYK2 |
0.649 | -0.139 | 1 | 0.626 |
JAK2 |
0.649 | -0.108 | 1 | 0.641 |
CK1G3 |
0.648 | -0.067 | -3 | 0.037 |
EPHB4 |
0.648 | -0.061 | -1 | 0.714 |
TXK |
0.646 | -0.025 | 1 | 0.650 |
JAK1 |
0.645 | -0.051 | 1 | 0.596 |
ABL2 |
0.645 | -0.065 | -1 | 0.713 |
CSF1R |
0.645 | -0.098 | 3 | 0.769 |
TEK |
0.644 | -0.012 | 3 | 0.703 |
FGR |
0.644 | -0.084 | 1 | 0.646 |
PDGFRB |
0.643 | -0.069 | 3 | 0.789 |
LCK |
0.643 | -0.058 | -1 | 0.748 |
ALPHAK3 |
0.643 | -0.066 | -1 | 0.660 |
ABL1 |
0.642 | -0.086 | -1 | 0.715 |
DDR2 |
0.641 | 0.038 | 3 | 0.700 |
JAK3 |
0.641 | -0.085 | 1 | 0.624 |
YES1 |
0.641 | -0.103 | -1 | 0.770 |
KDR |
0.641 | -0.022 | 3 | 0.727 |
AXL |
0.640 | -0.048 | 3 | 0.736 |
FGFR2 |
0.640 | -0.045 | 3 | 0.745 |
PDGFRA |
0.639 | -0.073 | 3 | 0.790 |
FGFR1 |
0.639 | -0.041 | 3 | 0.729 |
ITK |
0.639 | -0.081 | -1 | 0.730 |
FER |
0.638 | -0.146 | 1 | 0.671 |
INSRR |
0.638 | -0.080 | 3 | 0.708 |
HCK |
0.637 | -0.128 | -1 | 0.745 |
SRMS |
0.637 | -0.107 | 1 | 0.646 |
FLT3 |
0.636 | -0.091 | 3 | 0.785 |
WEE1_TYR |
0.636 | -0.041 | -1 | 0.699 |
STLK3 |
0.636 | -0.132 | 1 | 0.579 |
BLK |
0.636 | -0.073 | -1 | 0.739 |
EPHA4 |
0.635 | -0.082 | 2 | 0.733 |
EPHA1 |
0.635 | -0.049 | 3 | 0.754 |
EPHB3 |
0.635 | -0.089 | -1 | 0.703 |
ALK |
0.635 | -0.067 | 3 | 0.709 |
MET |
0.634 | -0.064 | 3 | 0.766 |
BTK |
0.634 | -0.144 | -1 | 0.716 |
EPHB1 |
0.634 | -0.127 | 1 | 0.648 |
PTK2B |
0.633 | -0.034 | -1 | 0.716 |
MERTK |
0.632 | -0.102 | 3 | 0.731 |
KIT |
0.632 | -0.125 | 3 | 0.771 |
TEC |
0.632 | -0.092 | -1 | 0.667 |
EPHB2 |
0.631 | -0.119 | -1 | 0.691 |
LTK |
0.630 | -0.072 | 3 | 0.715 |
BMX |
0.630 | -0.084 | -1 | 0.628 |
PTK6 |
0.627 | -0.117 | -1 | 0.683 |
EPHA7 |
0.626 | -0.085 | 2 | 0.752 |
FRK |
0.626 | -0.113 | -1 | 0.738 |
YANK2 |
0.625 | -0.049 | 2 | 0.432 |
FGFR3 |
0.625 | -0.080 | 3 | 0.715 |
ERBB2 |
0.624 | -0.113 | 1 | 0.595 |
FYN |
0.624 | -0.090 | -1 | 0.721 |
EPHA3 |
0.624 | -0.104 | 2 | 0.718 |
MATK |
0.623 | -0.083 | -1 | 0.640 |
CK1G2 |
0.623 | -0.057 | -3 | 0.066 |
FLT1 |
0.623 | -0.095 | -1 | 0.694 |
NTRK2 |
0.623 | -0.151 | 3 | 0.720 |
LYN |
0.623 | -0.126 | 3 | 0.690 |
NTRK1 |
0.621 | -0.163 | -1 | 0.702 |
FLT4 |
0.621 | -0.107 | 3 | 0.696 |
INSR |
0.620 | -0.143 | 3 | 0.681 |
NTRK3 |
0.620 | -0.109 | -1 | 0.653 |
SRC |
0.616 | -0.112 | -1 | 0.723 |
EPHA8 |
0.616 | -0.093 | -1 | 0.676 |
EPHA5 |
0.614 | -0.113 | 2 | 0.722 |
MUSK |
0.614 | -0.096 | 1 | 0.501 |
CSK |
0.613 | -0.118 | 2 | 0.762 |
PTK2 |
0.611 | -0.055 | -1 | 0.646 |
EGFR |
0.610 | -0.112 | 1 | 0.521 |
FGFR4 |
0.609 | -0.105 | -1 | 0.649 |
SYK |
0.609 | -0.071 | -1 | 0.625 |
EPHA2 |
0.603 | -0.109 | -1 | 0.628 |
IGF1R |
0.603 | -0.138 | 3 | 0.618 |
ERBB4 |
0.601 | -0.083 | 1 | 0.530 |
ZAP70 |
0.598 | -0.030 | -1 | 0.568 |
FES |
0.595 | -0.137 | -1 | 0.619 |