Motif 350 (n=205)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RRK4 | LBHD2 | S41 | ochoa | LBH domain-containing protein 2 | None |
| A1L390 | PLEKHG3 | S1081 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NNA2 | SRRM3 | S330 | ochoa | Serine/arginine repetitive matrix protein 3 | May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}. |
| A7KAX9 | ARHGAP32 | S1401 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A8CG34 | POM121C | S80 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| B7ZBB8 | PPP1R3G | S86 | ochoa | Protein phosphatase 1 regulatory subunit 3G | Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity). {ECO:0000250}. |
| C9JI98 | TMEM238 | S124 | ochoa | Transmembrane protein 238 | None |
| E7EW31 | PROB1 | S855 | ochoa | Proline-rich basic protein 1 | None |
| O00255 | MEN1 | S487 | psp | Menin | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. {ECO:0000250|UniProtKB:O88559, ECO:0000269|PubMed:11274402, ECO:0000269|PubMed:11526476, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:12874027, ECO:0000269|PubMed:14992727, ECO:0000269|PubMed:22327296}. |
| O00257 | CBX4 | S434 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O00409 | FOXN3 | S85 | ochoa|psp | Forkhead box protein N3 (Checkpoint suppressor 1) | Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269|PubMed:16102918}. |
| O14639 | ABLIM1 | S706 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14654 | IRS4 | S427 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14746 | TERT | S227 | psp | Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2) | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. {ECO:0000269|PubMed:14963003, ECO:0000269|PubMed:15082768, ECO:0000269|PubMed:15857955, ECO:0000269|PubMed:17026956, ECO:0000269|PubMed:17264120, ECO:0000269|PubMed:17296728, ECO:0000269|PubMed:17548608, ECO:0000269|PubMed:19188162, ECO:0000269|PubMed:19567472, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:19777057, ECO:0000269|PubMed:9389643}. |
| O15234 | CASC3 | S265 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| O15523 | DDX3Y | S101 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43166 | SIPA1L1 | S1116 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43290 | SART1 | S84 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43295 | SRGAP3 | S1030 | ochoa | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}. |
| O43379 | WDR62 | S1228 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43464 | HTRA2 | S212 | ochoa|psp | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269|PubMed:10873535, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269|PubMed:10995577}. |
| O43521 | BCL2L11 | S94 | ochoa|psp | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}. |
| O60292 | SIPA1L3 | S146 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60292 | SIPA1L3 | S1667 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60336 | MAPKBP1 | S1246 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60667 | FCMR | S310 | ochoa | Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso) | High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (PubMed:19858324, PubMed:22675200, PubMed:36949194, PubMed:37095205). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:21908732, PubMed:28230186). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (PubMed:19858324, PubMed:22675200, PubMed:25601920, PubMed:30840890). {ECO:0000269|PubMed:19858324, ECO:0000269|PubMed:21908732, ECO:0000269|PubMed:22675200, ECO:0000269|PubMed:25601920, ECO:0000269|PubMed:28230186, ECO:0000269|PubMed:30840890, ECO:0000269|PubMed:36949194, ECO:0000269|PubMed:37095205}. |
| O75140 | DEPDC5 | S570 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75385 | ULK1 | S467 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75420 | GIGYF1 | S157 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O94804 | STK10 | S417 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94875 | SORBS2 | S843 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O94915 | FRYL | S2332 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94967 | WDR47 | S304 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95071 | UBR5 | S2369 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95180 | CACNA1H | S1198 | psp | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
| O95685 | PPP1R3D | S25 | ochoa | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. |
| P02730 | SLC4A1 | S349 | ochoa | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P08151 | GLI1 | S640 | ochoa|psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P12755 | SKI | S326 | psp | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P14416 | DRD2 | S228 | psp | D(2) dopamine receptor (Dopamine D2 receptor) | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). {ECO:0000250|UniProtKB:P61168, ECO:0000269|PubMed:21645528}. |
| P23769 | GATA2 | S290 | ochoa|psp | Endothelial transcription factor GATA-2 (GATA-binding protein 2) | Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
| P27694 | RPA1 | S392 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P30518 | AVPR2 | S255 | psp | Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) | Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. {ECO:0000269|PubMed:19440390}. |
| P31152 | MAPK4 | S386 | ochoa | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| P32942 | ICAM3 | S518 | ochoa|psp | Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50) | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000269|PubMed:1448173, ECO:0000269|PubMed:23775590}. |
| P33993 | MCM7 | S156 | ochoa | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35408 | PTGER4 | S222 | ochoa | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P40429 | RPL13A | S77 | psp | Large ribosomal subunit protein uL13 (23 kDa highly basic protein) (60S ribosomal protein L13a) | Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318). {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P47736 | RAP1GAP | S441 | ochoa|psp | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49815 | TSC2 | S1420 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P49916 | LIG3 | S472 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P50991 | CCT4 | S444 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P53667 | LIMK1 | S298 | ochoa | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}. |
| P57740 | NUP107 | S57 | ochoa | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:12552102, PubMed:15229283). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}. |
| Q02410 | APBA1 | S568 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q03001 | DST | S7422 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q04637 | EIF4G1 | S1187 | ochoa|psp | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q07157 | TJP1 | S885 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07666 | KHDRBS1 | S20 | ochoa | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q09019 | DMWD | S495 | ochoa | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}. |
| Q10713 | PMPCA | S35 | ochoa | Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. {ECO:0000269|PubMed:25808372}. |
| Q12830 | BPTF | S198 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12923 | PTPN13 | S926 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13523 | PRP4K | S427 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13625 | TP53BP2 | S458 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q13796 | SHROOM2 | S116 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14151 | SAFB2 | S787 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q15036 | SNX17 | S409 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15772 | SPEG | S2109 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15772 | SPEG | S2496 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15773 | MLF2 | S216 | ochoa | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | None |
| Q16134 | ETFDH | S551 | ochoa | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase) | Accepts electrons from ETF and reduces ubiquinone. {ECO:0000269|PubMed:12049629}. |
| Q2KHR2 | RFX7 | S1225 | ochoa | DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) | Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250|UniProtKB:A0A1L8H0H2, ECO:0000269|PubMed:29967452, ECO:0000269|PubMed:34197623}. |
| Q2TAC6 | KIF19 | S895 | ochoa | Kinesin-like protein KIF19 | Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. {ECO:0000250}. |
| Q2TAZ0 | ATG2A | S403 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q2V2M9 | FHOD3 | S366 | ochoa | FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) | Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269|PubMed:21149568}. |
| Q4VX76 | SYTL3 | S231 | ochoa | Synaptotagmin-like protein 3 (Exophilin-6) | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). {ECO:0000250}. |
| Q52LW3 | ARHGAP29 | S1019 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5JQS6 | GCSAML | S106 | ochoa | Germinal center-associated signaling and motility-like protein | None |
| Q5M775 | SPECC1 | S112 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T0N5 | FNBP1L | S489 | ochoa | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}. |
| Q5T1R4 | HIVEP3 | S993 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T5P2 | KIAA1217 | S433 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T7N3 | KANK4 | S74 | ochoa | KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. {ECO:0000269|PubMed:17996375}. |
| Q5T8R8 | DOCK8-AS1 | S48 | ochoa | Uncharacterized protein DOCK8-AS1 (DOCK8 antisense RNA 1) | None |
| Q5TBA9 | FRY | S2367 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5U4P2 | ASPHD1 | S158 | ochoa | Aspartate beta-hydroxylase domain-containing protein 1 (EC 1.14.11.-) | None |
| Q5VT52 | RPRD2 | S1185 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VZ46 | KIAA1614 | S1107 | ochoa | Uncharacterized protein KIAA1614 | None |
| Q66K74 | MAP1S | S731 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q676U5 | ATG16L1 | S289 | ochoa|psp | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q6F5E8 | CARMIL2 | S1268 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6F5E8 | CARMIL2 | S1362 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6GTX8 | LAIR1 | S268 | ochoa | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305) | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:10764762, ECO:0000269|PubMed:11069054, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:12072189, ECO:0000269|PubMed:15939744, ECO:0000269|PubMed:15950745, ECO:0000269|PubMed:16380958, ECO:0000269|PubMed:9285412, ECO:0000269|PubMed:9692876}. |
| Q6JBY9 | RCSD1 | S179 | ochoa|psp | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6NSI3 | FAM53A | S125 | ochoa | Protein FAM53A (Dorsal neural-tube nuclear protein) | May play an important role in neural development; the dorsomedial roof of the third ventricle. {ECO:0000250|UniProtKB:Q5ZKN5}. |
| Q6PJG9 | LRFN4 | S610 | ochoa | Leucine-rich repeat and fibronectin type-III domain-containing protein 4 | Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}. |
| Q6T4R5 | NHS | S471 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6V0I7 | FAT4 | S4755 | ochoa | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}. |
| Q6X4W1 | NSMF | S164 | ochoa | NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor) | Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269|PubMed:20025934}. |
| Q6ZN55 | ZNF574 | S298 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZNL6 | FGD5 | S740 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZNL6 | FGD5 | S744 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZSZ5 | ARHGEF18 | S85 | ochoa | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. |
| Q702N8 | XIRP1 | S684 | ochoa | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}. |
| Q702N8 | XIRP1 | S1121 | ochoa | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}. |
| Q70EL1 | USP54 | S1420 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7L2J0 | MEPCE | S175 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z3C6 | ATG9A | S761 | ochoa|psp | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
| Q7Z591 | AKNA | S996 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q86UX7 | FERMT3 | S117 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86X51 | EZHIP | S387 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86YD1 | PTOV1 | S36 | ochoa|psp | Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) | May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}. |
| Q86YV0 | RASAL3 | S819 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IVN8 | SBSPON | S100 | ochoa | Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin) | None |
| Q8IXZ2 | ZC3H3 | S220 | ochoa | Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) | Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}. |
| Q8IYJ3 | SYTL1 | S470 | ochoa | Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) | May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. |
| Q8IZW8 | TNS4 | S198 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N3F8 | MICALL1 | S196 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4C8 | MINK1 | S601 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N5S9 | CAMKK1 | S74 | ochoa|psp | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8N684 | CPSF7 | S191 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8NC56 | LEMD2 | S139 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8NDF8 | TENT4B | S484 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8NFP9 | NBEA | S1321 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8TF72 | SHROOM3 | S162 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8TF72 | SHROOM3 | S1242 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q92502 | STARD8 | S498 | ochoa | StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) | Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. {ECO:0000269|PubMed:17976533}. |
| Q92738 | USP6NL | S617 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q92834 | RPGR | S418 | ochoa | X-linked retinitis pigmentosa GTPase regulator | Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:20631154). GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A (PubMed:20631154). GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (By similarity). Involved in photoreceptor integrity (By similarity). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia (PubMed:21933838). May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). {ECO:0000250|UniProtKB:Q9R0X5, ECO:0000269|PubMed:20631154, ECO:0000269|PubMed:21933838}. |
| Q92995 | USP13 | S104 | ochoa | Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response (PubMed:21571647, PubMed:32772043, PubMed:33592542). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy (PubMed:32101753). Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB (PubMed:32772043). In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1 (PubMed:33592542). Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion (PubMed:36585612). Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1 (PubMed:23940278, PubMed:28534493). {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28534493, ECO:0000269|PubMed:32101753, ECO:0000269|PubMed:32772043, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:36585612}. |
| Q969G9 | NKD1 | S297 | ochoa | Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}. |
| Q969V6 | MRTFA | S312 | ochoa|psp | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96B18 | DACT3 | S426 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96CC6 | RHBDF1 | S51 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96EY5 | MVB12A | S163 | psp | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
| Q96G01 | BICD1 | S548 | ochoa | Protein bicaudal D homolog 1 (Bic-D 1) | Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. |
| Q96G74 | OTUD5 | S431 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96GN5 | CDCA7L | S261 | ochoa | Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}. |
| Q96HA1 | POM121 | S80 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96JH7 | VCPIP1 | S46 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
| Q96LB3 | IFT74 | S32 | ochoa | Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) | Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium (PubMed:23990561). Binds beta-tubulin via its basic region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561). Essential for flagellogenesis during spermatogenesis (PubMed:33689014). {ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:33689014}. |
| Q96N67 | DOCK7 | S182 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96PE2 | ARHGEF17 | S735 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PE2 | ARHGEF17 | S961 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96QB1 | DLC1 | S598 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96RJ3 | TNFRSF13C | S113 | ochoa | Tumor necrosis factor receptor superfamily member 13C (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268) | B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:11591325, ECO:0000269|PubMed:12387744}. |
| Q96T58 | SPEN | Y1908 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96TC7 | RMDN3 | S46 | ochoa|psp | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99759 | MAP3K3 | S250 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q99767 | APBA2 | S480 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Q9BRD0 | BUD13 | S184 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BSQ5 | CCM2 | S393 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BY89 | KIAA1671 | S244 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0D0 | PHACTR1 | S67 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
| Q9C0F1 | CEP44 | S331 | ochoa | Centrosomal protein of 44 kDa (Cep44) (HBV PreS1-transactivated protein 3) (PS1TP3) | Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall (PubMed:32060285). Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome (PubMed:31974111). {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}. |
| Q9C0J8 | WDR33 | S1279 | ochoa | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. |
| Q9GZU2 | PEG3 | S196 | ochoa | Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}. |
| Q9H0W5 | CCDC8 | S273 | ochoa | Coiled-coil domain-containing protein 8 | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. |
| Q9H0W8 | SMG9 | S53 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H1H9 | KIF13A | S1384 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H1Z4 | WDR13 | S113 | ochoa | WD repeat-containing protein 13 | None |
| Q9H400 | LIME1 | S95 | ochoa | Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule) | Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}. |
| Q9H6R4 | NOL6 | S121 | ochoa | Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:11895476, ECO:0000269|PubMed:34516797}. |
| Q9H6Y5 | MAGIX | S21 | ochoa | PDZ domain-containing protein MAGIX | None |
| Q9H773 | DCTPP1 | S138 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
| Q9H792 | PEAK1 | S819 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7N4 | SCAF1 | Y494 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H9F9 | ACTR5 | S76 | ochoa | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}. |
| Q9HAW4 | CLSPN | S798 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9NVW2 | RLIM | S215 | psp | E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Q9NY59 | SMPD3 | S209 | ochoa|psp | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NZN5 | ARHGEF12 | S608 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9NZV7 | ZIM2 | S71 | ochoa | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| Q9P1Y5 | CAMSAP3 | S431 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P212 | PLCE1 | S1151 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
| Q9P219 | CCDC88C | S1887 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P244 | LRFN1 | S674 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P265 | DIP2B | S100 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UEY8 | ADD3 | S402 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UGU0 | TCF20 | S1007 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UGU0 | TCF20 | S1792 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UJK0 | TSR3 | S259 | ochoa | 18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (HsTsr3) | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). {ECO:0000305|PubMed:27084949}. |
| Q9UJM3 | ERRFI1 | S251 | ochoa|psp | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9UKA4 | AKAP11 | S444 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UPT8 | ZC3H4 | S159 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQ35 | SRRM2 | S1616 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y227 | ENTPD4 | S597 | ochoa | Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42) | [Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452). {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}.; FUNCTION: [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}. |
| Q9Y2E4 | DIP2C | S89 | ochoa | Disco-interacting protein 2 homolog C (DIP2 homolog C) | None |
| Q9Y2G4 | ANKRD6 | S289 | ochoa | Ankyrin repeat domain-containing protein 6 (Diversin) | Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000250}. |
| Q9Y2H9 | MAST1 | S827 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2J0 | RPH3A | S272 | ochoa | Rabphilin-3A (Exophilin-1) | Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). {ECO:0000250|UniProtKB:P47709}. |
| Q9Y2U8 | LEMD3 | S291 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3M8 | STARD13 | S589 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y4B5 | MTCL1 | S1523 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4B6 | DCAF1 | S979 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4F5 | CEP170B | S619 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6X9 | MORC2 | S615 | ochoa | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}. |
| O95785 | WIZ | S1094 | Sugiyama | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| Q96GM8 | TOE1 | S420 | Sugiyama | Target of EGR1 protein 1 | Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}. |
| Q6PD62 | CTR9 | S1081 | EPSD|PSP | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q8NAF0 | ZNF579 | S455 | Sugiyama | Zinc finger protein 579 | May be involved in transcriptional regulation. |
| Q9BQK8 | LPIN3 | S262 | Sugiyama | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}. |
| Q12809 | KCNH2 | S284 | SIGNOR | Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1) | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Channel properties are modulated by cAMP and subunit assembly (PubMed:10837251). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (PubMed:10219239, PubMed:9230439). {ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:10753933, ECO:0000269|PubMed:10790218, ECO:0000269|PubMed:10837251, ECO:0000269|PubMed:11997281, ECO:0000269|PubMed:12063277, ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:22314138, ECO:0000269|PubMed:22359612, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:9230439, ECO:0000269|PubMed:9351446, ECO:0000269|PubMed:9765245}.; FUNCTION: [Isoform A-USO]: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:9765245}.; FUNCTION: [Isoform B-USO]: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421}. |
| Q8WUA4 | GTF3C2 | S379 | Sugiyama | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000263 | 3.580 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.001662 | 2.779 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.002103 | 2.677 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.003002 | 2.523 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.003516 | 2.454 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.003793 | 2.421 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.003750 | 2.426 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.005245 | 2.280 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005245 | 2.280 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.005345 | 2.272 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.007442 | 2.128 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.007198 | 2.143 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.008823 | 2.054 |
| R-HSA-68875 | Mitotic Prophase | 0.009551 | 2.020 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.009662 | 2.015 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.010967 | 1.960 |
| R-HSA-8953854 | Metabolism of RNA | 0.010747 | 1.969 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.012684 | 1.897 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.013639 | 1.865 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.013639 | 1.865 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.015669 | 1.805 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.015669 | 1.805 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.016744 | 1.776 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.015669 | 1.805 |
| R-HSA-9930044 | Nuclear RNA decay | 0.015669 | 1.805 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.016744 | 1.776 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.012684 | 1.897 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.014634 | 1.835 |
| R-HSA-162582 | Signal Transduction | 0.013875 | 1.858 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.017860 | 1.748 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.019016 | 1.721 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.021450 | 1.669 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.023695 | 1.625 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.025882 | 1.587 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.025882 | 1.587 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.025406 | 1.595 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.025406 | 1.595 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.022728 | 1.643 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.024046 | 1.619 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.023695 | 1.625 |
| R-HSA-9036092 | Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus... | 0.026230 | 1.581 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.026805 | 1.572 |
| R-HSA-73887 | Death Receptor Signaling | 0.028450 | 1.546 |
| R-HSA-9612973 | Autophagy | 0.029852 | 1.525 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.030766 | 1.512 |
| R-HSA-8854214 | TBC/RABGAPs | 0.031247 | 1.505 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.032303 | 1.491 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.034410 | 1.463 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.036051 | 1.443 |
| R-HSA-109581 | Apoptosis | 0.034327 | 1.464 |
| R-HSA-75153 | Apoptotic execution phase | 0.036051 | 1.443 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.038090 | 1.419 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.038090 | 1.419 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 0.039088 | 1.408 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.044239 | 1.354 |
| R-HSA-72187 | mRNA 3'-end processing | 0.046723 | 1.330 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 0.051776 | 1.286 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.050728 | 1.295 |
| R-HSA-429947 | Deadenylation of mRNA | 0.061049 | 1.214 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.068292 | 1.166 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.064297 | 1.192 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.064297 | 1.192 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.061049 | 1.214 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.065289 | 1.185 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.060907 | 1.215 |
| R-HSA-191859 | snRNP Assembly | 0.060907 | 1.215 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.065289 | 1.185 |
| R-HSA-1632852 | Macroautophagy | 0.061170 | 1.213 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.064636 | 1.190 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.050728 | 1.295 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.067533 | 1.170 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.065193 | 1.186 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.054606 | 1.263 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.061049 | 1.214 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.061049 | 1.214 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.060308 | 1.220 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.076654 | 1.115 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.158722 | 0.799 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.191631 | 0.718 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.223259 | 0.651 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.099745 | 1.001 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.233526 | 0.632 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.243657 | 0.613 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.116716 | 0.933 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.263522 | 0.579 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.301707 | 0.520 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.329046 | 0.483 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.130862 | 0.883 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.130862 | 0.883 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.209364 | 0.679 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.152233 | 0.817 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.243440 | 0.614 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.243440 | 0.614 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.258127 | 0.588 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.214888 | 0.668 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.214888 | 0.668 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.292408 | 0.534 |
| R-HSA-380287 | Centrosome maturation | 0.302175 | 0.520 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.155895 | 0.807 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.083558 | 1.078 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.329046 | 0.483 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.223259 | 0.651 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.310941 | 0.507 |
| R-HSA-191650 | Regulation of gap junction activity | 0.076654 | 1.115 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.212856 | 0.672 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.253655 | 0.596 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.273259 | 0.563 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.355320 | 0.449 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.088849 | 1.051 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.223259 | 0.651 |
| R-HSA-5620924 | Intraflagellar transport | 0.171151 | 0.767 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.249792 | 0.602 |
| R-HSA-72172 | mRNA Splicing | 0.179658 | 0.746 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.249792 | 0.602 |
| R-HSA-388479 | Vasopressin-like receptors | 0.076654 | 1.115 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.134347 | 0.872 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.184483 | 0.734 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.147458 | 0.831 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.076654 | 1.115 |
| R-HSA-390651 | Dopamine receptors | 0.076654 | 1.115 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.124479 | 0.905 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.136044 | 0.866 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.147458 | 0.831 |
| R-HSA-176974 | Unwinding of DNA | 0.147458 | 0.831 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.147458 | 0.831 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.202314 | 0.694 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.320054 | 0.495 |
| R-HSA-68882 | Mitotic Anaphase | 0.096765 | 1.014 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.098223 | 1.008 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.296801 | 0.528 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.088849 | 1.051 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.223259 | 0.651 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.204534 | 0.689 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.355320 | 0.449 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.302175 | 0.520 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.331316 | 0.480 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.204630 | 0.689 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.124479 | 0.905 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.136044 | 0.866 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.158722 | 0.799 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.212856 | 0.672 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.310941 | 0.507 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.124965 | 0.903 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.223920 | 0.650 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.282623 | 0.549 |
| R-HSA-180786 | Extension of Telomeres | 0.223920 | 0.650 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.134347 | 0.872 |
| R-HSA-5617833 | Cilium Assembly | 0.302732 | 0.519 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.076654 | 1.115 |
| R-HSA-69190 | DNA strand elongation | 0.091545 | 1.038 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.345765 | 0.461 |
| R-HSA-68886 | M Phase | 0.170570 | 0.768 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.346678 | 0.460 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.267559 | 0.573 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.136044 | 0.866 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.339599 | 0.469 |
| R-HSA-69481 | G2/M Checkpoints | 0.292662 | 0.534 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.158722 | 0.799 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.212856 | 0.672 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.082568 | 1.083 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.314305 | 0.503 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.292349 | 0.534 |
| R-HSA-5693538 | Homology Directed Repair | 0.256879 | 0.590 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.124479 | 0.905 |
| R-HSA-425381 | Bicarbonate transporters | 0.169837 | 0.770 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.202314 | 0.694 |
| R-HSA-8875878 | MET promotes cell motility | 0.121066 | 0.917 |
| R-HSA-163615 | PKA activation | 0.263522 | 0.579 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.243440 | 0.614 |
| R-HSA-9609690 | HCMV Early Events | 0.320601 | 0.494 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.158722 | 0.799 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.219058 | 0.659 |
| R-HSA-9609646 | HCMV Infection | 0.290624 | 0.537 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.253655 | 0.596 |
| R-HSA-9610379 | HCMV Late Events | 0.205129 | 0.688 |
| R-HSA-8949664 | Processing of SMDT1 | 0.202314 | 0.694 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.253655 | 0.596 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.282867 | 0.548 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.091821 | 1.037 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.107891 | 0.967 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.218332 | 0.661 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.350559 | 0.455 |
| R-HSA-5358508 | Mismatch Repair | 0.263522 | 0.579 |
| R-HSA-1640170 | Cell Cycle | 0.264962 | 0.577 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.167492 | 0.776 |
| R-HSA-111933 | Calmodulin induced events | 0.112406 | 0.949 |
| R-HSA-165159 | MTOR signalling | 0.143375 | 0.844 |
| R-HSA-373755 | Semaphorin interactions | 0.243440 | 0.614 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.191631 | 0.718 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.202314 | 0.694 |
| R-HSA-111997 | CaM pathway | 0.112406 | 0.949 |
| R-HSA-199991 | Membrane Trafficking | 0.278324 | 0.555 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.355320 | 0.449 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.256276 | 0.591 |
| R-HSA-111996 | Ca-dependent events | 0.143375 | 0.844 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.332559 | 0.478 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.116716 | 0.933 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.273259 | 0.563 |
| R-HSA-392517 | Rap1 signalling | 0.273259 | 0.563 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.292349 | 0.534 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.157145 | 0.804 |
| R-HSA-9663891 | Selective autophagy | 0.139886 | 0.854 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.355320 | 0.449 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.084800 | 1.072 |
| R-HSA-5205647 | Mitophagy | 0.103919 | 0.983 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.138845 | 0.857 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.191139 | 0.719 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.273259 | 0.563 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.301707 | 0.520 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.310941 | 0.507 |
| R-HSA-112043 | PLC beta mediated events | 0.233667 | 0.631 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.191139 | 0.719 |
| R-HSA-168255 | Influenza Infection | 0.125820 | 0.900 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.253332 | 0.596 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.169837 | 0.770 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.191631 | 0.718 |
| R-HSA-1483213 | Synthesis of PE | 0.355320 | 0.449 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.174618 | 0.758 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.310941 | 0.507 |
| R-HSA-112316 | Neuronal System | 0.119170 | 0.924 |
| R-HSA-3371556 | Cellular response to heat stress | 0.106944 | 0.971 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.136044 | 0.866 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.147458 | 0.831 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.202314 | 0.694 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.301707 | 0.520 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.191619 | 0.718 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.209364 | 0.679 |
| R-HSA-112040 | G-protein mediated events | 0.263027 | 0.580 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.278290 | 0.556 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.273259 | 0.563 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.329046 | 0.483 |
| R-HSA-5688426 | Deubiquitination | 0.303452 | 0.518 |
| R-HSA-70171 | Glycolysis | 0.184483 | 0.734 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.223259 | 0.651 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.077598 | 1.110 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.165521 | 0.781 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.083558 | 1.078 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.310941 | 0.507 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.273259 | 0.563 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.282867 | 0.548 |
| R-HSA-201451 | Signaling by BMP | 0.355320 | 0.449 |
| R-HSA-6806834 | Signaling by MET | 0.326480 | 0.486 |
| R-HSA-422475 | Axon guidance | 0.135787 | 0.867 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.320054 | 0.495 |
| R-HSA-9675108 | Nervous system development | 0.181649 | 0.741 |
| R-HSA-162587 | HIV Life Cycle | 0.205129 | 0.688 |
| R-HSA-70326 | Glucose metabolism | 0.253332 | 0.596 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.072014 | 1.143 |
| R-HSA-5619102 | SLC transporter disorders | 0.102190 | 0.991 |
| R-HSA-5357801 | Programmed Cell Death | 0.081507 | 1.089 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.072014 | 1.143 |
| R-HSA-75893 | TNF signaling | 0.209364 | 0.679 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.282976 | 0.548 |
| R-HSA-2028269 | Signaling by Hippo | 0.253655 | 0.596 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.081031 | 1.091 |
| R-HSA-211000 | Gene Silencing by RNA | 0.211456 | 0.675 |
| R-HSA-9607240 | FLT3 Signaling | 0.134347 | 0.872 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.357637 | 0.447 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.363849 | 0.439 |
| R-HSA-8850843 | Phosphate bond hydrolysis by NTPDase proteins | 0.363849 | 0.439 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.363849 | 0.439 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.364868 | 0.438 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.369612 | 0.432 |
| R-HSA-156902 | Peptide chain elongation | 0.369612 | 0.432 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.369612 | 0.432 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.372265 | 0.429 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.372265 | 0.429 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.372265 | 0.429 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.372265 | 0.429 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.379056 | 0.421 |
| R-HSA-73884 | Base Excision Repair | 0.379056 | 0.421 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.380570 | 0.420 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.380570 | 0.420 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.383757 | 0.416 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.388766 | 0.410 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.388766 | 0.410 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.388766 | 0.410 |
| R-HSA-391251 | Protein folding | 0.393112 | 0.405 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.393112 | 0.405 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.393481 | 0.405 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.396854 | 0.401 |
| R-HSA-69306 | DNA Replication | 0.397041 | 0.401 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.397041 | 0.401 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.402402 | 0.395 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.404835 | 0.393 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.404835 | 0.393 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.404835 | 0.393 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.404835 | 0.393 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.404835 | 0.393 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.407022 | 0.390 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.411625 | 0.385 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.411625 | 0.385 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.411625 | 0.385 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.412712 | 0.384 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.412712 | 0.384 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.412712 | 0.384 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.413306 | 0.384 |
| R-HSA-9711097 | Cellular response to starvation | 0.414751 | 0.382 |
| R-HSA-1296071 | Potassium Channels | 0.416211 | 0.381 |
| R-HSA-162906 | HIV Infection | 0.416272 | 0.381 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.419235 | 0.378 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.420484 | 0.376 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.420484 | 0.376 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.420484 | 0.376 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.420484 | 0.376 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.420484 | 0.376 |
| R-HSA-157579 | Telomere Maintenance | 0.420778 | 0.376 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.420778 | 0.376 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.421791 | 0.375 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.428154 | 0.368 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.428154 | 0.368 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.429858 | 0.367 |
| R-HSA-72312 | rRNA processing | 0.431051 | 0.365 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.434370 | 0.362 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.435723 | 0.361 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.435723 | 0.361 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.435723 | 0.361 |
| R-HSA-3371511 | HSF1 activation | 0.435723 | 0.361 |
| R-HSA-8853659 | RET signaling | 0.435723 | 0.361 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.435783 | 0.361 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.438863 | 0.358 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.443193 | 0.353 |
| R-HSA-419037 | NCAM1 interactions | 0.443193 | 0.353 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.443193 | 0.353 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.443193 | 0.353 |
| R-HSA-192823 | Viral mRNA Translation | 0.447791 | 0.349 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.450564 | 0.346 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.450564 | 0.346 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.452224 | 0.345 |
| R-HSA-111885 | Opioid Signalling | 0.452224 | 0.345 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.459959 | 0.337 |
| R-HSA-72306 | tRNA processing | 0.459959 | 0.337 |
| R-HSA-9646399 | Aggrephagy | 0.465015 | 0.333 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.465015 | 0.333 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.469756 | 0.328 |
| R-HSA-69239 | Synthesis of DNA | 0.469756 | 0.328 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.472099 | 0.326 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.476956 | 0.322 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.478395 | 0.320 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.479089 | 0.320 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.479089 | 0.320 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.485987 | 0.313 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.492794 | 0.307 |
| R-HSA-2559583 | Cellular Senescence | 0.493704 | 0.307 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.499511 | 0.301 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.499511 | 0.301 |
| R-HSA-373752 | Netrin-1 signaling | 0.499511 | 0.301 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.499616 | 0.301 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.503626 | 0.298 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.506140 | 0.296 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.506140 | 0.296 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.507949 | 0.294 |
| R-HSA-9675135 | Diseases of DNA repair | 0.512681 | 0.290 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.512681 | 0.290 |
| R-HSA-2262752 | Cellular responses to stress | 0.517942 | 0.286 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.519136 | 0.285 |
| R-HSA-1483191 | Synthesis of PC | 0.519136 | 0.285 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.527378 | 0.278 |
| R-HSA-73893 | DNA Damage Bypass | 0.531792 | 0.274 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.531792 | 0.274 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.531792 | 0.274 |
| R-HSA-68877 | Mitotic Prometaphase | 0.535960 | 0.271 |
| R-HSA-73886 | Chromosome Maintenance | 0.536395 | 0.271 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.537995 | 0.269 |
| R-HSA-912446 | Meiotic recombination | 0.544116 | 0.264 |
| R-HSA-9864848 | Complex IV assembly | 0.544116 | 0.264 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.544116 | 0.264 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.544314 | 0.264 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.545349 | 0.263 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.550157 | 0.260 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.550157 | 0.260 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.550157 | 0.260 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.550157 | 0.260 |
| R-HSA-69206 | G1/S Transition | 0.556015 | 0.255 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.556118 | 0.255 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.556118 | 0.255 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.556118 | 0.255 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.556118 | 0.255 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.556118 | 0.255 |
| R-HSA-72649 | Translation initiation complex formation | 0.562000 | 0.250 |
| R-HSA-74160 | Gene expression (Transcription) | 0.567931 | 0.246 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.573533 | 0.241 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.579185 | 0.237 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.584763 | 0.233 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.584763 | 0.233 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.589723 | 0.229 |
| R-HSA-8979227 | Triglyceride metabolism | 0.590267 | 0.229 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.590267 | 0.229 |
| R-HSA-983189 | Kinesins | 0.595699 | 0.225 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.595699 | 0.225 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.596891 | 0.224 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.601059 | 0.221 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.601059 | 0.221 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.601059 | 0.221 |
| R-HSA-1268020 | Mitochondrial protein import | 0.606348 | 0.217 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.606348 | 0.217 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.606348 | 0.217 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.606348 | 0.217 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.611301 | 0.214 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.611568 | 0.214 |
| R-HSA-8848021 | Signaling by PTK6 | 0.611568 | 0.214 |
| R-HSA-6807070 | PTEN Regulation | 0.614795 | 0.211 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.616719 | 0.210 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.621801 | 0.206 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.621801 | 0.206 |
| R-HSA-913531 | Interferon Signaling | 0.624508 | 0.204 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.631766 | 0.199 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.631905 | 0.199 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.636650 | 0.196 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.641885 | 0.193 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.646226 | 0.190 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.646226 | 0.190 |
| R-HSA-69242 | S Phase | 0.648420 | 0.188 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.650919 | 0.186 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.650919 | 0.186 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.650919 | 0.186 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.650919 | 0.186 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.654860 | 0.184 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.655550 | 0.183 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.655550 | 0.183 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.660120 | 0.180 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.663519 | 0.178 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.664629 | 0.177 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.664629 | 0.177 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.669079 | 0.175 |
| R-HSA-8852135 | Protein ubiquitination | 0.669079 | 0.175 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.673471 | 0.172 |
| R-HSA-5689603 | UCH proteinases | 0.673471 | 0.172 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.673471 | 0.172 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.682080 | 0.166 |
| R-HSA-216083 | Integrin cell surface interactions | 0.682080 | 0.166 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.685661 | 0.164 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.690463 | 0.161 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.697339 | 0.157 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.702628 | 0.153 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.702628 | 0.153 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.706576 | 0.151 |
| R-HSA-1500620 | Meiosis | 0.710471 | 0.148 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.710471 | 0.148 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.714316 | 0.146 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.718109 | 0.144 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.718109 | 0.144 |
| R-HSA-418555 | G alpha (s) signalling events | 0.719621 | 0.143 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.721853 | 0.142 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.724426 | 0.140 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.724973 | 0.140 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.732789 | 0.135 |
| R-HSA-611105 | Respiratory electron transport | 0.737976 | 0.132 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.743297 | 0.129 |
| R-HSA-73894 | DNA Repair | 0.745286 | 0.128 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.746707 | 0.127 |
| R-HSA-1474290 | Collagen formation | 0.750073 | 0.125 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.753394 | 0.123 |
| R-HSA-69275 | G2/M Transition | 0.757693 | 0.121 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.759904 | 0.119 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.759904 | 0.119 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.762419 | 0.118 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.762900 | 0.118 |
| R-HSA-6798695 | Neutrophil degranulation | 0.763531 | 0.117 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.766243 | 0.116 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.775441 | 0.110 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.775942 | 0.110 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.778427 | 0.109 |
| R-HSA-1483255 | PI Metabolism | 0.778427 | 0.109 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.784279 | 0.106 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.790797 | 0.102 |
| R-HSA-195721 | Signaling by WNT | 0.796072 | 0.099 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.813823 | 0.089 |
| R-HSA-397014 | Muscle contraction | 0.815061 | 0.089 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.816300 | 0.088 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.816934 | 0.088 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.828202 | 0.082 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.830489 | 0.081 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.835859 | 0.078 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.835859 | 0.078 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.839337 | 0.076 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.839337 | 0.076 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.844671 | 0.073 |
| R-HSA-114608 | Platelet degranulation | 0.849753 | 0.071 |
| R-HSA-8956319 | Nucleotide catabolism | 0.853728 | 0.069 |
| R-HSA-15869 | Metabolism of nucleotides | 0.855567 | 0.068 |
| R-HSA-1474165 | Reproduction | 0.857599 | 0.067 |
| R-HSA-5576891 | Cardiac conduction | 0.859496 | 0.066 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.863215 | 0.064 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.866984 | 0.062 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.867607 | 0.062 |
| R-HSA-5173105 | O-linked glycosylation | 0.872089 | 0.059 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.878774 | 0.056 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.889647 | 0.051 |
| R-HSA-9609507 | Protein localization | 0.898190 | 0.047 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.899549 | 0.046 |
| R-HSA-372790 | Signaling by GPCR | 0.901409 | 0.045 |
| R-HSA-388396 | GPCR downstream signalling | 0.907329 | 0.042 |
| R-HSA-446728 | Cell junction organization | 0.907538 | 0.042 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.911453 | 0.040 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.915335 | 0.038 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.921134 | 0.036 |
| R-HSA-1483257 | Phospholipid metabolism | 0.923134 | 0.035 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.923227 | 0.035 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.923227 | 0.035 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.924253 | 0.034 |
| R-HSA-3781865 | Diseases of glycosylation | 0.933789 | 0.030 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.935548 | 0.029 |
| R-HSA-212436 | Generic Transcription Pathway | 0.935625 | 0.029 |
| R-HSA-1500931 | Cell-Cell communication | 0.938997 | 0.027 |
| R-HSA-72766 | Translation | 0.939660 | 0.027 |
| R-HSA-597592 | Post-translational protein modification | 0.942292 | 0.026 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.943667 | 0.025 |
| R-HSA-428157 | Sphingolipid metabolism | 0.947337 | 0.023 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.948041 | 0.023 |
| R-HSA-1474244 | Extracellular matrix organization | 0.948376 | 0.023 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.948737 | 0.023 |
| R-HSA-9679506 | SARS-CoV Infections | 0.949545 | 0.022 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.953370 | 0.021 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.953850 | 0.021 |
| R-HSA-418990 | Adherens junctions interactions | 0.958684 | 0.018 |
| R-HSA-8951664 | Neddylation | 0.960322 | 0.018 |
| R-HSA-157118 | Signaling by NOTCH | 0.969299 | 0.014 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.971690 | 0.012 |
| R-HSA-421270 | Cell-cell junction organization | 0.973539 | 0.012 |
| R-HSA-392499 | Metabolism of proteins | 0.973599 | 0.012 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.974727 | 0.011 |
| R-HSA-418594 | G alpha (i) signalling events | 0.978540 | 0.009 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.978974 | 0.009 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.980614 | 0.009 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.984178 | 0.007 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.985610 | 0.006 |
| R-HSA-9824446 | Viral Infection Pathways | 0.987057 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 0.988471 | 0.005 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.991116 | 0.004 |
| R-HSA-449147 | Signaling by Interleukins | 0.992210 | 0.003 |
| R-HSA-109582 | Hemostasis | 0.994689 | 0.002 |
| R-HSA-1266738 | Developmental Biology | 0.995324 | 0.002 |
| R-HSA-1280218 | Adaptive Immune System | 0.996056 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.996406 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 0.996864 | 0.001 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.997445 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.997614 | 0.001 |
| R-HSA-168249 | Innate Immune System | 0.997803 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998302 | 0.001 |
| R-HSA-168256 | Immune System | 0.998621 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999373 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999939 | 0.000 |
| R-HSA-1643685 | Disease | 0.999995 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
SRPK2 |
0.842 | 0.725 | -3 | 0.775 |
SRPK1 |
0.837 | 0.684 | -3 | 0.699 |
RSK2 |
0.829 | 0.698 | -3 | 0.658 |
MAPKAPK2 |
0.826 | 0.668 | -3 | 0.659 |
P90RSK |
0.825 | 0.724 | -3 | 0.660 |
SRPK3 |
0.823 | 0.654 | -3 | 0.701 |
RSK3 |
0.823 | 0.686 | -3 | 0.655 |
CDKL5 |
0.823 | 0.676 | -3 | 0.629 |
PRKX |
0.822 | 0.575 | -3 | 0.689 |
PRKD2 |
0.821 | 0.634 | -3 | 0.603 |
RSK4 |
0.821 | 0.661 | -3 | 0.689 |
SBK |
0.820 | 0.788 | -3 | 0.832 |
CDKL1 |
0.819 | 0.771 | -3 | 0.606 |
MSK2 |
0.819 | 0.670 | -3 | 0.675 |
AKT2 |
0.819 | 0.711 | -3 | 0.746 |
MSK1 |
0.818 | 0.609 | -3 | 0.660 |
SGK1 |
0.818 | 0.741 | -3 | 0.814 |
PIM1 |
0.818 | 0.681 | -3 | 0.621 |
PIM3 |
0.817 | 0.627 | -3 | 0.525 |
PKACB |
0.817 | 0.525 | -2 | 0.599 |
CLK1 |
0.817 | 0.607 | -3 | 0.655 |
MAPKAPK3 |
0.817 | 0.657 | -3 | 0.570 |
CLK2 |
0.816 | 0.583 | -3 | 0.686 |
CLK4 |
0.816 | 0.601 | -3 | 0.649 |
HIPK4 |
0.815 | 0.523 | 1 | 0.790 |
PKACA |
0.815 | 0.549 | -2 | 0.550 |
NDR2 |
0.814 | 0.458 | -3 | 0.447 |
PRKD3 |
0.812 | 0.681 | -3 | 0.652 |
PRKD1 |
0.812 | 0.524 | -3 | 0.499 |
AKT3 |
0.811 | 0.686 | -3 | 0.805 |
PIM2 |
0.810 | 0.682 | -3 | 0.671 |
MAPKAPK5 |
0.807 | 0.684 | -3 | 0.649 |
P70S6KB |
0.807 | 0.617 | -3 | 0.584 |
NDR1 |
0.807 | 0.510 | -3 | 0.482 |
ICK |
0.806 | 0.617 | -3 | 0.537 |
PKACG |
0.806 | 0.463 | -2 | 0.669 |
LATS2 |
0.806 | 0.401 | -5 | 0.788 |
DYRK1A |
0.806 | 0.563 | 1 | 0.752 |
CAMK1D |
0.805 | 0.691 | -3 | 0.693 |
SGK3 |
0.804 | 0.599 | -3 | 0.601 |
CHK2 |
0.804 | 0.754 | -3 | 0.767 |
AKT1 |
0.803 | 0.628 | -3 | 0.705 |
BRSK1 |
0.803 | 0.524 | -3 | 0.557 |
HIPK2 |
0.802 | 0.413 | 1 | 0.640 |
CAMK2A |
0.802 | 0.494 | 2 | 0.804 |
P70S6K |
0.801 | 0.651 | -3 | 0.692 |
AMPKA2 |
0.800 | 0.535 | -3 | 0.504 |
DYRK3 |
0.800 | 0.531 | 1 | 0.756 |
SIK |
0.800 | 0.558 | -3 | 0.578 |
CAMK2D |
0.800 | 0.445 | -3 | 0.425 |
MAK |
0.800 | 0.556 | -2 | 0.715 |
NUAK2 |
0.800 | 0.549 | -3 | 0.504 |
CLK3 |
0.799 | 0.355 | 1 | 0.808 |
CAMK1B |
0.799 | 0.622 | -3 | 0.454 |
HIPK1 |
0.799 | 0.482 | 1 | 0.743 |
AURC |
0.799 | 0.295 | -2 | 0.587 |
DYRK2 |
0.798 | 0.380 | 1 | 0.728 |
MYLK4 |
0.797 | 0.507 | -2 | 0.703 |
SKMLCK |
0.797 | 0.433 | -2 | 0.803 |
CAMK2B |
0.796 | 0.416 | 2 | 0.801 |
CAMK1A |
0.796 | 0.675 | -3 | 0.735 |
AMPKA1 |
0.795 | 0.478 | -3 | 0.439 |
PKN3 |
0.795 | 0.503 | -3 | 0.496 |
PKG2 |
0.794 | 0.398 | -2 | 0.595 |
HIPK3 |
0.792 | 0.470 | 1 | 0.756 |
QSK |
0.791 | 0.417 | 4 | 0.813 |
PAK1 |
0.791 | 0.347 | -2 | 0.724 |
NUAK1 |
0.791 | 0.512 | -3 | 0.561 |
MOK |
0.791 | 0.598 | 1 | 0.754 |
MELK |
0.791 | 0.533 | -3 | 0.518 |
CAMK1G |
0.790 | 0.596 | -3 | 0.627 |
CAMLCK |
0.790 | 0.489 | -2 | 0.769 |
CDC7 |
0.790 | 0.160 | 1 | 0.843 |
DCAMKL1 |
0.788 | 0.576 | -3 | 0.558 |
DAPK2 |
0.788 | 0.562 | -3 | 0.419 |
AURB |
0.788 | 0.287 | -2 | 0.587 |
BRSK2 |
0.787 | 0.391 | -3 | 0.469 |
DYRK4 |
0.786 | 0.323 | 1 | 0.652 |
PAK3 |
0.786 | 0.318 | -2 | 0.715 |
DYRK1B |
0.786 | 0.373 | 1 | 0.680 |
CAMK4 |
0.786 | 0.429 | -3 | 0.461 |
MARK4 |
0.785 | 0.241 | 4 | 0.846 |
TSSK1 |
0.785 | 0.373 | -3 | 0.419 |
PKN2 |
0.784 | 0.396 | -3 | 0.438 |
CRIK |
0.784 | 0.662 | -3 | 0.723 |
PAK6 |
0.783 | 0.228 | -2 | 0.630 |
PKN1 |
0.782 | 0.573 | -3 | 0.663 |
MRCKB |
0.782 | 0.577 | -3 | 0.637 |
WNK1 |
0.782 | 0.274 | -2 | 0.805 |
COT |
0.781 | 0.037 | 2 | 0.792 |
MNK2 |
0.781 | 0.252 | -2 | 0.709 |
LATS1 |
0.780 | 0.387 | -3 | 0.412 |
PKG1 |
0.780 | 0.462 | -2 | 0.512 |
PHKG1 |
0.779 | 0.394 | -3 | 0.477 |
MOS |
0.779 | 0.140 | 1 | 0.869 |
IKKB |
0.779 | 0.083 | -2 | 0.687 |
PKCD |
0.779 | 0.339 | 2 | 0.702 |
PAK2 |
0.778 | 0.307 | -2 | 0.710 |
QIK |
0.778 | 0.358 | -3 | 0.408 |
DAPK1 |
0.778 | 0.554 | -3 | 0.608 |
DAPK3 |
0.778 | 0.554 | -3 | 0.573 |
AURA |
0.778 | 0.247 | -2 | 0.571 |
NIM1 |
0.778 | 0.286 | 3 | 0.778 |
CHK1 |
0.777 | 0.359 | -3 | 0.408 |
MRCKA |
0.777 | 0.550 | -3 | 0.604 |
NIK |
0.776 | 0.434 | -3 | 0.338 |
SMMLCK |
0.776 | 0.538 | -3 | 0.531 |
PAK5 |
0.776 | 0.279 | -2 | 0.598 |
TSSK2 |
0.776 | 0.291 | -5 | 0.881 |
MTOR |
0.775 | 0.017 | 1 | 0.815 |
NLK |
0.774 | 0.151 | 1 | 0.842 |
MNK1 |
0.774 | 0.263 | -2 | 0.718 |
MARK3 |
0.774 | 0.254 | 4 | 0.773 |
PAK4 |
0.774 | 0.263 | -2 | 0.601 |
PRPK |
0.774 | -0.005 | -1 | 0.835 |
CAMK2G |
0.774 | 0.047 | 2 | 0.807 |
RAF1 |
0.773 | 0.138 | 1 | 0.860 |
DCAMKL2 |
0.773 | 0.433 | -3 | 0.524 |
DMPK1 |
0.773 | 0.571 | -3 | 0.615 |
GRK1 |
0.773 | 0.096 | -2 | 0.797 |
MST4 |
0.773 | 0.163 | 2 | 0.761 |
PDHK4 |
0.772 | -0.077 | 1 | 0.868 |
TBK1 |
0.772 | -0.011 | 1 | 0.783 |
ATR |
0.771 | 0.078 | 1 | 0.804 |
MARK1 |
0.771 | 0.287 | 4 | 0.794 |
ROCK2 |
0.771 | 0.542 | -3 | 0.561 |
RIPK1 |
0.770 | 0.213 | 1 | 0.827 |
PKCB |
0.770 | 0.304 | 2 | 0.625 |
MARK2 |
0.770 | 0.239 | 4 | 0.744 |
TGFBR2 |
0.769 | 0.084 | -2 | 0.715 |
KIS |
0.769 | 0.049 | 1 | 0.713 |
IKKE |
0.768 | -0.031 | 1 | 0.779 |
PKCG |
0.768 | 0.266 | 2 | 0.635 |
PDHK1 |
0.767 | -0.078 | 1 | 0.863 |
RIPK3 |
0.767 | 0.061 | 3 | 0.728 |
BCKDK |
0.767 | -0.018 | -1 | 0.796 |
SNRK |
0.766 | 0.305 | 2 | 0.651 |
PKCA |
0.766 | 0.234 | 2 | 0.629 |
GCN2 |
0.765 | -0.096 | 2 | 0.761 |
WNK3 |
0.765 | 0.113 | 1 | 0.822 |
PASK |
0.765 | 0.449 | -3 | 0.457 |
HUNK |
0.765 | 0.042 | 2 | 0.741 |
MASTL |
0.764 | 0.052 | -2 | 0.758 |
PHKG2 |
0.764 | 0.366 | -3 | 0.497 |
PKCT |
0.764 | 0.361 | 2 | 0.635 |
ERK5 |
0.764 | 0.026 | 1 | 0.813 |
GRK5 |
0.764 | -0.037 | -3 | 0.173 |
CDK7 |
0.764 | 0.100 | 1 | 0.684 |
CHAK2 |
0.764 | 0.038 | -1 | 0.841 |
PKCH |
0.764 | 0.296 | 2 | 0.621 |
ROCK1 |
0.764 | 0.542 | -3 | 0.608 |
BMPR2 |
0.763 | -0.110 | -2 | 0.794 |
PKCE |
0.763 | 0.387 | 2 | 0.614 |
ULK2 |
0.762 | -0.113 | 2 | 0.731 |
CK1E |
0.762 | -0.019 | -3 | 0.097 |
GRK6 |
0.761 | 0.045 | 1 | 0.828 |
IKKA |
0.760 | -0.046 | -2 | 0.688 |
PKCZ |
0.759 | 0.219 | 2 | 0.688 |
ATM |
0.759 | 0.047 | 1 | 0.742 |
SSTK |
0.758 | 0.229 | 4 | 0.804 |
DSTYK |
0.758 | -0.120 | 2 | 0.797 |
GRK4 |
0.758 | -0.048 | -2 | 0.801 |
FAM20C |
0.757 | 0.028 | 2 | 0.609 |
DLK |
0.757 | 0.125 | 1 | 0.838 |
DNAPK |
0.756 | 0.054 | 1 | 0.706 |
CK1D |
0.755 | -0.029 | -3 | 0.076 |
CDK10 |
0.755 | 0.203 | 1 | 0.646 |
PKCI |
0.755 | 0.274 | 2 | 0.645 |
CDK8 |
0.755 | 0.009 | 1 | 0.679 |
WNK4 |
0.754 | 0.241 | -2 | 0.801 |
CK1A2 |
0.754 | -0.030 | -3 | 0.100 |
TTBK2 |
0.753 | -0.027 | 2 | 0.635 |
ULK1 |
0.753 | -0.149 | -3 | 0.129 |
GRK7 |
0.753 | 0.084 | 1 | 0.753 |
CDK19 |
0.753 | 0.020 | 1 | 0.644 |
NEK7 |
0.753 | -0.142 | -3 | 0.149 |
IRE1 |
0.752 | 0.058 | 1 | 0.791 |
BMPR1B |
0.752 | 0.030 | 1 | 0.787 |
CK1G1 |
0.752 | -0.050 | -3 | 0.089 |
TGFBR1 |
0.751 | -0.004 | -2 | 0.738 |
ALK4 |
0.751 | 0.000 | -2 | 0.762 |
NEK6 |
0.751 | -0.124 | -2 | 0.765 |
MLK1 |
0.751 | -0.090 | 2 | 0.717 |
ANKRD3 |
0.750 | 0.009 | 1 | 0.866 |
NEK9 |
0.750 | -0.111 | 2 | 0.751 |
CDK14 |
0.750 | 0.152 | 1 | 0.661 |
MEK1 |
0.749 | 0.022 | 2 | 0.810 |
SMG1 |
0.749 | -0.021 | 1 | 0.754 |
JNK2 |
0.749 | 0.059 | 1 | 0.641 |
CDK18 |
0.749 | 0.057 | 1 | 0.613 |
MLK2 |
0.749 | -0.074 | 2 | 0.757 |
CDK9 |
0.747 | 0.055 | 1 | 0.675 |
DRAK1 |
0.747 | 0.132 | 1 | 0.751 |
PKR |
0.747 | 0.078 | 1 | 0.840 |
P38A |
0.746 | 0.048 | 1 | 0.719 |
CDK13 |
0.746 | 0.021 | 1 | 0.661 |
VRK2 |
0.745 | -0.012 | 1 | 0.881 |
CDK12 |
0.745 | 0.057 | 1 | 0.639 |
ALK2 |
0.745 | 0.010 | -2 | 0.743 |
NEK2 |
0.745 | -0.063 | 2 | 0.729 |
PDK1 |
0.744 | 0.339 | 1 | 0.813 |
PLK1 |
0.744 | -0.051 | -2 | 0.699 |
JNK3 |
0.744 | 0.032 | 1 | 0.670 |
CHAK1 |
0.743 | 0.009 | 2 | 0.746 |
PRP4 |
0.742 | -0.034 | -3 | 0.141 |
GRK2 |
0.742 | -0.007 | -2 | 0.701 |
MPSK1 |
0.742 | 0.080 | 1 | 0.773 |
P38B |
0.741 | 0.035 | 1 | 0.653 |
YSK4 |
0.741 | -0.073 | 1 | 0.805 |
TLK2 |
0.740 | -0.070 | 1 | 0.778 |
ACVR2A |
0.739 | -0.047 | -2 | 0.705 |
IRE2 |
0.739 | -0.003 | 2 | 0.662 |
PLK3 |
0.739 | -0.086 | 2 | 0.744 |
PLK4 |
0.739 | -0.036 | 2 | 0.613 |
MLK3 |
0.738 | -0.070 | 2 | 0.646 |
GSK3B |
0.738 | 0.075 | 4 | 0.580 |
ACVR2B |
0.738 | -0.052 | -2 | 0.721 |
BRAF |
0.738 | 0.041 | -4 | 0.716 |
GRK3 |
0.737 | -0.002 | -2 | 0.680 |
ERK1 |
0.737 | 0.022 | 1 | 0.647 |
MEK5 |
0.737 | 0.029 | 2 | 0.770 |
MST3 |
0.737 | 0.079 | 2 | 0.728 |
IRAK4 |
0.736 | 0.062 | 1 | 0.808 |
CDK17 |
0.735 | 0.027 | 1 | 0.561 |
P38G |
0.735 | 0.028 | 1 | 0.562 |
BMPR1A |
0.735 | -0.004 | 1 | 0.772 |
CDK5 |
0.735 | 0.014 | 1 | 0.692 |
TLK1 |
0.734 | -0.038 | -2 | 0.770 |
GSK3A |
0.734 | 0.070 | 4 | 0.587 |
BUB1 |
0.734 | 0.172 | -5 | 0.804 |
PERK |
0.733 | -0.059 | -2 | 0.745 |
ERK2 |
0.733 | 0.012 | 1 | 0.685 |
MLK4 |
0.732 | -0.097 | 2 | 0.638 |
CDK1 |
0.732 | 0.005 | 1 | 0.635 |
MEKK3 |
0.732 | -0.039 | 1 | 0.833 |
PBK |
0.731 | 0.139 | 1 | 0.769 |
HRI |
0.731 | -0.091 | -2 | 0.759 |
TAO3 |
0.731 | 0.058 | 1 | 0.817 |
IRAK1 |
0.730 | -0.024 | -1 | 0.789 |
TTBK1 |
0.730 | -0.064 | 2 | 0.565 |
MEKK2 |
0.729 | -0.041 | 2 | 0.740 |
MEKK1 |
0.729 | -0.097 | 1 | 0.834 |
HPK1 |
0.729 | 0.136 | 1 | 0.815 |
ZAK |
0.728 | -0.065 | 1 | 0.809 |
LKB1 |
0.728 | -0.021 | -3 | 0.167 |
NEK5 |
0.727 | -0.092 | 1 | 0.829 |
CK1A |
0.727 | -0.044 | -3 | 0.052 |
CK2A2 |
0.727 | 0.021 | 1 | 0.707 |
PINK1 |
0.726 | -0.121 | 1 | 0.799 |
GAK |
0.726 | 0.063 | 1 | 0.833 |
CDK4 |
0.726 | 0.100 | 1 | 0.621 |
LOK |
0.725 | 0.111 | -2 | 0.690 |
NEK11 |
0.725 | -0.030 | 1 | 0.815 |
GCK |
0.725 | 0.072 | 1 | 0.817 |
LRRK2 |
0.724 | 0.149 | 2 | 0.767 |
HASPIN |
0.724 | 0.157 | -1 | 0.765 |
MEKK6 |
0.724 | 0.070 | 1 | 0.812 |
CDK16 |
0.724 | 0.023 | 1 | 0.575 |
TAO2 |
0.724 | 0.036 | 2 | 0.760 |
CAMKK2 |
0.724 | -0.053 | -2 | 0.651 |
KHS1 |
0.722 | 0.109 | 1 | 0.814 |
CDK2 |
0.722 | -0.047 | 1 | 0.710 |
MAP3K15 |
0.722 | 0.024 | 1 | 0.797 |
P38D |
0.721 | 0.002 | 1 | 0.584 |
KHS2 |
0.720 | 0.128 | 1 | 0.816 |
NEK8 |
0.720 | 0.011 | 2 | 0.728 |
RIPK2 |
0.719 | 0.013 | 1 | 0.784 |
CDK3 |
0.719 | 0.005 | 1 | 0.579 |
HGK |
0.719 | 0.007 | 3 | 0.793 |
TNIK |
0.719 | 0.040 | 3 | 0.794 |
JNK1 |
0.719 | 0.010 | 1 | 0.617 |
CAMKK1 |
0.719 | -0.141 | -2 | 0.651 |
STK33 |
0.719 | -0.002 | 2 | 0.590 |
CK2A1 |
0.718 | 0.018 | 1 | 0.686 |
SLK |
0.718 | 0.035 | -2 | 0.665 |
NEK4 |
0.718 | -0.058 | 1 | 0.817 |
MINK |
0.718 | 0.005 | 1 | 0.820 |
TAK1 |
0.717 | 0.035 | 1 | 0.808 |
VRK1 |
0.715 | 0.006 | 2 | 0.752 |
PLK2 |
0.715 | -0.084 | -3 | 0.107 |
ERK7 |
0.715 | -0.022 | 2 | 0.443 |
NEK1 |
0.714 | -0.053 | 1 | 0.816 |
YANK3 |
0.713 | 0.028 | 2 | 0.388 |
MST2 |
0.712 | -0.118 | 1 | 0.835 |
MEK2 |
0.712 | -0.102 | 2 | 0.777 |
PDHK3_TYR |
0.712 | 0.111 | 4 | 0.924 |
EEF2K |
0.711 | -0.051 | 3 | 0.760 |
CDK6 |
0.711 | 0.017 | 1 | 0.645 |
NEK3 |
0.711 | -0.036 | 1 | 0.800 |
YSK1 |
0.711 | 0.010 | 2 | 0.713 |
MST1 |
0.707 | -0.086 | 1 | 0.818 |
LIMK2_TYR |
0.705 | 0.173 | -3 | 0.249 |
MAP2K4_TYR |
0.705 | 0.123 | -1 | 0.843 |
TESK1_TYR |
0.704 | 0.100 | 3 | 0.849 |
PKMYT1_TYR |
0.704 | 0.082 | 3 | 0.828 |
CK1G3 |
0.703 | -0.062 | -3 | 0.046 |
MAP2K7_TYR |
0.701 | 0.013 | 2 | 0.817 |
BIKE |
0.699 | 0.020 | 1 | 0.721 |
MAP2K6_TYR |
0.699 | 0.013 | -1 | 0.843 |
TNK2 |
0.698 | 0.109 | 3 | 0.749 |
TAO1 |
0.698 | 0.036 | 1 | 0.771 |
TTK |
0.698 | -0.017 | -2 | 0.733 |
ASK1 |
0.697 | -0.035 | 1 | 0.786 |
PINK1_TYR |
0.697 | 0.145 | 1 | 0.835 |
PDHK4_TYR |
0.697 | -0.037 | 2 | 0.851 |
MYO3B |
0.696 | -0.013 | 2 | 0.736 |
PDHK1_TYR |
0.695 | -0.040 | -1 | 0.847 |
RET |
0.695 | 0.030 | 1 | 0.820 |
BMPR2_TYR |
0.695 | -0.023 | -1 | 0.824 |
OSR1 |
0.694 | -0.078 | 2 | 0.749 |
EPHA6 |
0.693 | 0.019 | -1 | 0.809 |
DDR1 |
0.693 | 0.063 | 4 | 0.842 |
LIMK1_TYR |
0.692 | 0.032 | 2 | 0.795 |
EPHB4 |
0.691 | -0.012 | -1 | 0.795 |
TNK1 |
0.689 | 0.098 | 3 | 0.761 |
MST1R |
0.689 | -0.012 | 3 | 0.793 |
DDR2 |
0.687 | 0.139 | 3 | 0.733 |
ALPHAK3 |
0.685 | -0.055 | -1 | 0.722 |
NEK10_TYR |
0.685 | 0.059 | 1 | 0.698 |
MYO3A |
0.685 | -0.058 | 1 | 0.811 |
ROS1 |
0.685 | -0.036 | 3 | 0.748 |
TYRO3 |
0.684 | -0.069 | 3 | 0.766 |
TYK2 |
0.684 | -0.103 | 1 | 0.819 |
ABL2 |
0.684 | -0.030 | -1 | 0.796 |
AAK1 |
0.684 | 0.031 | 1 | 0.620 |
SRMS |
0.683 | -0.058 | 1 | 0.844 |
TXK |
0.683 | -0.021 | 1 | 0.831 |
STLK3 |
0.683 | -0.111 | 1 | 0.783 |
JAK2 |
0.682 | -0.119 | 1 | 0.818 |
EPHA4 |
0.681 | -0.057 | 2 | 0.741 |
AXL |
0.681 | -0.010 | 3 | 0.767 |
ABL1 |
0.681 | -0.049 | -1 | 0.795 |
FGFR2 |
0.680 | -0.046 | 3 | 0.795 |
FGR |
0.680 | -0.077 | 1 | 0.839 |
CSF1R |
0.680 | -0.097 | 3 | 0.773 |
INSRR |
0.680 | -0.036 | 3 | 0.739 |
JAK3 |
0.680 | -0.064 | 1 | 0.802 |
EPHB1 |
0.679 | -0.076 | 1 | 0.856 |
MERTK |
0.679 | -0.045 | 3 | 0.777 |
FER |
0.679 | -0.109 | 1 | 0.850 |
EPHB3 |
0.679 | -0.066 | -1 | 0.782 |
YES1 |
0.679 | -0.071 | -1 | 0.824 |
TNNI3K_TYR |
0.679 | -0.002 | 1 | 0.845 |
EPHB2 |
0.678 | -0.068 | -1 | 0.777 |
EPHA1 |
0.678 | 0.002 | 3 | 0.760 |
PDGFRB |
0.678 | -0.036 | 3 | 0.780 |
ITK |
0.677 | -0.056 | -1 | 0.801 |
CK1G2 |
0.677 | -0.052 | -3 | 0.064 |
JAK1 |
0.676 | -0.039 | 1 | 0.789 |
KDR |
0.676 | -0.029 | 3 | 0.752 |
LCK |
0.675 | -0.051 | -1 | 0.811 |
HCK |
0.675 | -0.103 | -1 | 0.811 |
LTK |
0.674 | -0.008 | 3 | 0.746 |
BLK |
0.673 | -0.040 | -1 | 0.803 |
FGFR1 |
0.673 | -0.088 | 3 | 0.764 |
EPHA7 |
0.673 | -0.051 | 2 | 0.736 |
TEK |
0.673 | -0.080 | 3 | 0.715 |
BTK |
0.672 | -0.096 | -1 | 0.791 |
PTK2B |
0.672 | -0.016 | -1 | 0.783 |
BMX |
0.672 | -0.044 | -1 | 0.712 |
YANK2 |
0.671 | -0.042 | 2 | 0.408 |
FLT3 |
0.671 | -0.065 | 3 | 0.767 |
ALK |
0.671 | -0.034 | 3 | 0.718 |
KIT |
0.670 | -0.120 | 3 | 0.773 |
EPHA3 |
0.669 | -0.079 | 2 | 0.718 |
PDGFRA |
0.669 | -0.083 | 3 | 0.770 |
MET |
0.669 | -0.068 | 3 | 0.774 |
TEC |
0.668 | -0.069 | -1 | 0.744 |
WEE1_TYR |
0.667 | -0.044 | -1 | 0.756 |
FYN |
0.667 | -0.065 | -1 | 0.777 |
NTRK1 |
0.667 | -0.127 | -1 | 0.787 |
FGFR3 |
0.666 | -0.088 | 3 | 0.767 |
EPHA5 |
0.666 | -0.062 | 2 | 0.733 |
PTK6 |
0.665 | -0.119 | -1 | 0.740 |
FLT1 |
0.664 | -0.096 | -1 | 0.779 |
ERBB2 |
0.663 | -0.115 | 1 | 0.763 |
FRK |
0.662 | -0.104 | -1 | 0.821 |
NTRK3 |
0.661 | -0.114 | -1 | 0.736 |
EPHA8 |
0.661 | -0.080 | -1 | 0.752 |
NTRK2 |
0.661 | -0.144 | 3 | 0.733 |
FLT4 |
0.660 | -0.102 | 3 | 0.742 |
INSR |
0.659 | -0.112 | 3 | 0.709 |
CSK |
0.659 | -0.091 | 2 | 0.736 |
LYN |
0.658 | -0.130 | 3 | 0.697 |
MATK |
0.656 | -0.097 | -1 | 0.717 |
SRC |
0.656 | -0.101 | -1 | 0.775 |
EGFR |
0.654 | -0.100 | 1 | 0.673 |
PTK2 |
0.654 | -0.044 | -1 | 0.718 |
FGFR4 |
0.652 | -0.110 | -1 | 0.727 |
SYK |
0.651 | -0.064 | -1 | 0.703 |
EPHA2 |
0.649 | -0.095 | -1 | 0.719 |
IGF1R |
0.645 | -0.113 | 3 | 0.657 |
ERBB4 |
0.643 | -0.083 | 1 | 0.682 |
MUSK |
0.642 | -0.113 | 1 | 0.665 |
FES |
0.637 | -0.121 | -1 | 0.691 |
ZAP70 |
0.632 | -0.060 | -1 | 0.640 |