Motif 35 (n=118)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5YKK6 | CNOT1 | S1061 | ochoa | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| A6H8Y1 | BDP1 | S1781 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NKT7 | RGPD3 | S1487 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| F5H423 | None | S62 | ochoa | ADP-ribosylation factor 3 | None |
| K7ERQ8 | None | S124 | ochoa | PCAF N-terminal domain-containing protein | None |
| O14715 | RGPD8 | S1486 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14908 | GIPC1 | S68 | ochoa | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | May be involved in G protein-linked signaling. |
| O15164 | TRIM24 | S217 | psp | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O43524 | FOXO3 | S232 | psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O43683 | BUB1 | S525 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60503 | ADCY9 | S1273 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60841 | EIF5B | S1168 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75369 | FLNB | S91 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O95239 | KIF4A | S507 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95466 | FMNL1 | S950 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95639 | CPSF4 | S230 | ochoa | Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}. |
| O95714 | HERC2 | S1601 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| P07437 | TUBB | S322 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DJD0 | RGPD1 | S1471 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1479 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P15408 | FOSL2 | S230 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P15924 | DSP | S2242 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P15927 | RPA2 | S72 | psp | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P17812 | CTPS1 | S210 | ochoa | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}. |
| P19174 | PLCG1 | S451 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P20339 | RAB5A | S123 | ochoa|psp | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P21333 | FLNA | S118 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23634 | ATP2B4 | S1115 | ochoa|psp | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P28749 | RBL1 | S1041 | ochoa | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P30043 | BLVRB | S82 | ochoa | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-) | Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:10620517, PubMed:18241201, PubMed:27207795, PubMed:38056462, PubMed:7929092). Promotes fetal heme degradation during development (PubMed:10858451, PubMed:18241201, PubMed:7929092). Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling (PubMed:27207795, PubMed:29500232, PubMed:38056462). Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone) (PubMed:10620517, PubMed:18241201, PubMed:7929092). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver (PubMed:10858451, PubMed:18241201, PubMed:7929092). Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult (PubMed:10858451, PubMed:18241201, PubMed:7929092). Does not reduce bilirubin IXalpha (PubMed:10858451, PubMed:18241201, PubMed:7929092). Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH (PubMed:10620517). Acts as a protein nitrosyltransferase by catalyzing nitrosylation of cysteine residues of target proteins, such as HMOX2, INSR and IRS1 (PubMed:38056462). S-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate (PubMed:38056462). Inhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition (PubMed:38056462). {ECO:0000269|PubMed:10620517, ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:18241201, ECO:0000269|PubMed:27207795, ECO:0000269|PubMed:29500232, ECO:0000269|PubMed:38056462, ECO:0000269|PubMed:7929092}. |
| P30101 | PDIA3 | S456 | ochoa | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| P31939 | ATIC | S450 | ochoa | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P38398 | BRCA1 | S308 | psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41252 | IARS1 | S136 | ochoa | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| P47756 | CAPZB | S226 | psp | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
| P49326 | FMO5 | S401 | ochoa | Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1) | Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:20947616, PubMed:26771671, PubMed:28783300). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). {ECO:0000250|UniProtKB:P97872, ECO:0000269|PubMed:20947616, ECO:0000269|PubMed:26771671, ECO:0000269|PubMed:28783300, ECO:0000269|PubMed:7872795, ECO:0000305|PubMed:26771671}. |
| P49792 | RANBP2 | S2462 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49916 | LIG3 | S913 | ochoa|psp | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P50993 | ATP1A2 | S439 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P51148 | RAB5C | S124 | ochoa | Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P51610 | HCFC1 | S666 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P52292 | KPNA2 | S62 | ochoa|psp | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P61020 | RAB5B | S123 | ochoa|psp | Ras-related protein Rab-5B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P61204 | ARF3 | S62 | ochoa | ADP-ribosylation factor 3 | GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. |
| P62280 | RPS11 | S135 | ochoa | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P68371 | TUBB4B | S322 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P84077 | ARF1 | S62 | ochoa | ADP-ribosylation factor 1 (EC 3.6.5.2) | Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:P84079, ECO:0000269|PubMed:8253837}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}. |
| Q03164 | KMT2A | S3644 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q13415 | ORC1 | S199 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13885 | TUBB2A | S322 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14999 | CUL7 | S616 | ochoa | Cullin-7 (CUL-7) | Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12481031, PubMed:12904573, PubMed:21572988, PubMed:21737058, PubMed:24793695, PubMed:35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed:21572988, PubMed:21737058, PubMed:24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328, PubMed:35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed:35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. {ECO:0000269|PubMed:12481031, ECO:0000269|PubMed:12904573, ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:21737058, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:35982156}. |
| Q15049 | MLC1 | S197 | psp | Membrane protein MLC1 (Megalencephalic leukoencephalopathy with subcortical cysts protein 1) | Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers (PubMed:22328087). Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx (PubMed:22328087). May function as regulatory protein of membrane protein complexes such as ion channels (Probable). {ECO:0000269|PubMed:22328087, ECO:0000305|PubMed:22328087}. |
| Q15746 | MYLK | S947 | ochoa|psp | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q15788 | NCOA1 | S569 | ochoa|psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q16666 | IFI16 | S153 | ochoa|psp | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q5JWR5 | DOP1A | S1023 | ochoa | Protein DOP1A | May be involved in protein traffic between late Golgi and early endosomes. {ECO:0000250|UniProtKB:Q03921}. |
| Q5VU65 | NUP210L | S523 | ochoa | Nuclear pore membrane glycoprotein 210-like (Nucleoporin 210 kDa-like) (Nucleoporin Nup210-like) | None |
| Q5W0Q7 | USPL1 | S200 | ochoa | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}. |
| Q658Y4 | FAM91A1 | S310 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6P1L8 | MRPL14 | S49 | ochoa | Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial) (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32) | Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). {ECO:0000305|PubMed:22829778}. |
| Q6T4R5 | NHS | S418 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6ZVD7 | STOX1 | S392 | ochoa | Storkhead-box protein 1 (Winged-helix domain-containing protein) | Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:24738702}.; FUNCTION: [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177). {ECO:0000269|PubMed:22253775, ECO:0000269|PubMed:22995177}. |
| Q6ZVL6 | KIAA1549L | S1310 | ochoa | UPF0606 protein KIAA1549L | None |
| Q7Z3J3 | RGPD4 | S1487 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86US8 | SMG6 | S363 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86UX7 | FERMT3 | S31 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86VP6 | CAND1 | S122 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q8IZT6 | ASPM | S605 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8WUP2 | FBLIM1 | S285 | ochoa | Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}. |
| Q8WWQ0 | PHIP | S1525 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WYP5 | AHCTF1 | S1944 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92731 | ESR2 | S87 | psp | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q92733 | PRCC | S241 | ochoa | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q92905 | COPS5 | S177 | psp | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) | Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}. |
| Q92930 | RAB8B | S111 | ochoa|psp | Ras-related protein Rab-8B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:P70550, ECO:0000269|PubMed:32344433, ECO:0000305}. |
| Q96I25 | RBM17 | S222 | ochoa|psp | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96Q05 | TRAPPC9 | S574 | ochoa | Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) (Tularik gene 1 protein) | Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269|PubMed:15951441}. |
| Q96RT1 | ERBIN | S569 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99570 | PIK3R4 | S814 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99666 | RGPD5 | S1486 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99700 | ATXN2 | S889 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BVA1 | TUBB2B | S322 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BVR0 | HERC2P3 | S328 | ochoa | Putative HERC2-like protein 3 | None |
| Q9H223 | EHD4 | S459 | ochoa | EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}. |
| Q9H3M0 | KCNF1 | S177 | ochoa | Voltage-gated potassium channel regulatory subunit KCNF1 (Potassium voltage-gated channel subfamily F member 1) (Voltage-gated potassium channel subunit Kv5.1) (kH1) | Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone. {ECO:0000250|UniProtKB:D4ADX7}. |
| Q9H4M9 | EHD1 | S456 | ochoa | EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:31615969}. |
| Q9H582 | ZNF644 | S820 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9NP61 | ARFGAP3 | S274 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NQE9 | HINT3 | S38 | ochoa | Adenosine 5'-monophosphoramidase HINT3 (EC 3.9.1.-) (Histidine triad nucleotide-binding protein 3) (HINT-3) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088). {ECO:0000269|PubMed:17870088}. |
| Q9NRE2 | TSHZ2 | S976 | ochoa | Teashirt homolog 2 (Ovarian cancer-related protein 10-2) (OVC10-2) (Zinc finger protein 218) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q9NVI1 | FANCI | S407 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NY74 | ETAA1 | S433 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZN3 | EHD3 | S456 | ochoa | EH domain-containing protein 3 (PAST homolog 3) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). {ECO:0000250|UniProtKB:Q9QXY6, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19139087, ECO:0000269|PubMed:21791287, ECO:0000269|PubMed:23781025, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000305|PubMed:20489164}. |
| Q9UEY8 | ADD3 | S600 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHB6 | LIMA1 | S617 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHD1 | CHORDC1 | S110 | ochoa | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) | Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}. |
| Q9ULJ3 | ZBTB21 | S144 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UPQ0 | LIMCH1 | S542 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9Y210 | TRPC6 | S847 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y2F5 | ICE1 | S1903 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2K9 | STXBP5L | S812 | psp | Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). {ECO:0000250|UniProtKB:Q5DQR4, ECO:0000269|PubMed:25504045}. |
| Q9Y4E5 | ZNF451 | S601 | ochoa | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}. |
| Q9Y4F3 | MARF1 | S66 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q9Y4X4 | KLF12 | S202 | ochoa | Krueppel-like factor 12 (Transcriptional repressor AP-2rep) | Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. |
| Q9Y520 | PRRC2C | S2143 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q3B891 | BRCA1 | S308 | GPS6 | BRCA1 DNA repair associated (BRCA1 protein) | None |
| Q8WW59 | SPRYD4 | S113 | Sugiyama | SPRY domain-containing protein 4 | None |
| O15075 | DCLK1 | S172 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| Q9NZL9 | MAT2B | S110 | Sugiyama | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
| O60563 | CCNT1 | S444 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| P48643 | CCT5 | S79 | Sugiyama | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P60842 | EIF4A1 | S189 | Sugiyama | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| Q14240 | EIF4A2 | S190 | Sugiyama | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q12778 | FOXO1 | S235 | PSP | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q03112 | MECOM | S1039 | SIGNOR | Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) | [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}. |
| Q6XUX3 | DSTYK | S770 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q8N568 | DCLK2 | S174 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q8NG66 | NEK11 | Y20 | Sugiyama | Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.682019e-07 | 6.434 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.942940e-06 | 5.306 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.942940e-06 | 5.306 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.553435e-06 | 5.184 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.363000e-06 | 5.078 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.195205e-05 | 4.923 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.142870e-05 | 4.942 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.541830e-05 | 4.812 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.594809e-05 | 4.586 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.478045e-05 | 4.349 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 5.313878e-05 | 4.275 |
| R-HSA-1640170 | Cell Cycle | 6.174594e-05 | 4.209 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 6.791115e-05 | 4.168 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 9.378972e-05 | 4.028 |
| R-HSA-68877 | Mitotic Prometaphase | 1.047490e-04 | 3.980 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.290393e-04 | 3.889 |
| R-HSA-437239 | Recycling pathway of L1 | 1.278302e-04 | 3.893 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.334049e-04 | 3.875 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.467988e-04 | 3.833 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.427033e-04 | 3.846 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.824285e-04 | 3.739 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.020532e-04 | 3.695 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.069684e-04 | 3.684 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.358251e-04 | 3.627 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.385887e-04 | 3.622 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.242024e-04 | 3.489 |
| R-HSA-983189 | Kinesins | 3.377437e-04 | 3.471 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.949069e-04 | 3.404 |
| R-HSA-190861 | Gap junction assembly | 4.759941e-04 | 3.322 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.575580e-04 | 3.254 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.628774e-04 | 3.179 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.461379e-04 | 3.127 |
| R-HSA-199991 | Membrane Trafficking | 7.122737e-04 | 3.147 |
| R-HSA-9646399 | Aggrephagy | 7.898858e-04 | 3.102 |
| R-HSA-913531 | Interferon Signaling | 8.168980e-04 | 3.088 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 9.208706e-04 | 3.036 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.068972e-03 | 2.971 |
| R-HSA-8854214 | TBC/RABGAPs | 1.066447e-03 | 2.972 |
| R-HSA-68882 | Mitotic Anaphase | 1.097362e-03 | 2.960 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.127038e-03 | 2.948 |
| R-HSA-190828 | Gap junction trafficking | 1.144973e-03 | 2.941 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.404775e-03 | 2.852 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.399959e-03 | 2.854 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.426876e-03 | 2.846 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.563767e-03 | 2.806 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.599222e-03 | 2.796 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.635723e-03 | 2.786 |
| R-HSA-429947 | Deadenylation of mRNA | 2.344493e-03 | 2.630 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.809950e-03 | 2.551 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.870925e-03 | 2.542 |
| R-HSA-8873719 | RAB geranylgeranylation | 3.012251e-03 | 2.521 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.146886e-03 | 2.502 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.170008e-03 | 2.499 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.338262e-03 | 2.476 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.902082e-03 | 2.409 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.205709e-03 | 2.376 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 4.209997e-03 | 2.376 |
| R-HSA-109582 | Hemostasis | 4.231077e-03 | 2.374 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 4.977051e-03 | 2.303 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.516499e-03 | 2.258 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.315265e-03 | 2.274 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.567026e-03 | 2.254 |
| R-HSA-373760 | L1CAM interactions | 5.649882e-03 | 2.248 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.830868e-03 | 2.234 |
| R-HSA-69205 | G1/S-Specific Transcription | 6.365489e-03 | 2.196 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 6.698568e-03 | 2.174 |
| R-HSA-8939211 | ESR-mediated signaling | 7.249563e-03 | 2.140 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.003526e-03 | 2.155 |
| R-HSA-9833482 | PKR-mediated signaling | 7.407171e-03 | 2.130 |
| R-HSA-69206 | G1/S Transition | 7.647694e-03 | 2.116 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 7.648736e-03 | 2.116 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 8.651449e-03 | 2.063 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.271587e-03 | 2.033 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.271587e-03 | 2.033 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 8.651449e-03 | 2.063 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 8.651449e-03 | 2.063 |
| R-HSA-68886 | M Phase | 8.603300e-03 | 2.065 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.716959e-03 | 2.012 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.851020e-03 | 2.007 |
| R-HSA-5617833 | Cilium Assembly | 9.943430e-03 | 2.002 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 9.954992e-03 | 2.002 |
| R-HSA-9663891 | Selective autophagy | 1.030863e-02 | 1.987 |
| R-HSA-391251 | Protein folding | 1.219877e-02 | 1.914 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.199646e-02 | 1.921 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.091876e-02 | 1.962 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.120106e-02 | 1.951 |
| R-HSA-1632852 | Macroautophagy | 1.239785e-02 | 1.907 |
| R-HSA-5620924 | Intraflagellar transport | 1.296937e-02 | 1.887 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.711675e-02 | 1.767 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.711675e-02 | 1.767 |
| R-HSA-72649 | Translation initiation complex formation | 1.695928e-02 | 1.771 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.842499e-02 | 1.735 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.719047e-02 | 1.765 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.613248e-02 | 1.792 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.686589e-02 | 1.773 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.719047e-02 | 1.765 |
| R-HSA-5578775 | Ion homeostasis | 1.842499e-02 | 1.735 |
| R-HSA-9612973 | Autophagy | 1.803072e-02 | 1.744 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.613248e-02 | 1.792 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.587696e-02 | 1.799 |
| R-HSA-597592 | Post-translational protein modification | 1.761802e-02 | 1.754 |
| R-HSA-1483255 | PI Metabolism | 1.710267e-02 | 1.767 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.995899e-02 | 1.700 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.008470e-02 | 1.697 |
| R-HSA-9824446 | Viral Infection Pathways | 2.071070e-02 | 1.684 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.075165e-02 | 1.683 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.078236e-02 | 1.682 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.156144e-02 | 1.666 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 2.556573e-02 | 1.592 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.316716e-02 | 1.635 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.316716e-02 | 1.635 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.682607e-02 | 1.571 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.682607e-02 | 1.571 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 2.556573e-02 | 1.592 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 2.556573e-02 | 1.592 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.497185e-02 | 1.603 |
| R-HSA-392499 | Metabolism of proteins | 2.561030e-02 | 1.592 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.643065e-02 | 1.578 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.770932e-02 | 1.557 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.812810e-02 | 1.551 |
| R-HSA-5693538 | Homology Directed Repair | 2.814830e-02 | 1.551 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.394259e-02 | 1.469 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.394259e-02 | 1.469 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.394259e-02 | 1.469 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.394259e-02 | 1.469 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.394259e-02 | 1.469 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.394259e-02 | 1.469 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.394259e-02 | 1.469 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.394259e-02 | 1.469 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.394259e-02 | 1.469 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.394259e-02 | 1.469 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.394259e-02 | 1.469 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.723823e-02 | 1.429 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.575732e-02 | 1.447 |
| R-HSA-69481 | G2/M Checkpoints | 3.533672e-02 | 1.452 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.723823e-02 | 1.429 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.723823e-02 | 1.429 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.469222e-02 | 1.460 |
| R-HSA-69275 | G2/M Transition | 3.325324e-02 | 1.478 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.444439e-02 | 1.463 |
| R-HSA-9830364 | Formation of the nephric duct | 2.986818e-02 | 1.525 |
| R-HSA-168256 | Immune System | 3.379571e-02 | 1.471 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.834749e-02 | 1.416 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.917906e-02 | 1.407 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.917906e-02 | 1.407 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.917906e-02 | 1.407 |
| R-HSA-9609690 | HCMV Early Events | 3.947247e-02 | 1.404 |
| R-HSA-162582 | Signal Transduction | 4.177329e-02 | 1.379 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 4.224796e-02 | 1.374 |
| R-HSA-167021 | PLC-gamma1 signalling | 4.224796e-02 | 1.374 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.249785e-02 | 1.372 |
| R-HSA-1538133 | G0 and Early G1 | 4.317314e-02 | 1.365 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.522483e-02 | 1.345 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.522483e-02 | 1.345 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 5.048243e-02 | 1.297 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 5.048243e-02 | 1.297 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 5.048243e-02 | 1.297 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 5.048243e-02 | 1.297 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 6.053698e-02 | 1.218 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.943371e-02 | 1.306 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 5.864661e-02 | 1.232 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.943371e-02 | 1.306 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.825279e-02 | 1.235 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.609031e-02 | 1.336 |
| R-HSA-73894 | DNA Repair | 4.755535e-02 | 1.323 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.943371e-02 | 1.306 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.158941e-02 | 1.287 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.158941e-02 | 1.287 |
| R-HSA-397014 | Muscle contraction | 5.157765e-02 | 1.288 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.921633e-02 | 1.308 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5.599966e-02 | 1.252 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.167245e-02 | 1.287 |
| R-HSA-111933 | Calmodulin induced events | 5.377830e-02 | 1.269 |
| R-HSA-111997 | CaM pathway | 5.377830e-02 | 1.269 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.053698e-02 | 1.218 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.613405e-02 | 1.336 |
| R-HSA-69306 | DNA Replication | 6.167564e-02 | 1.210 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.285154e-02 | 1.202 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 6.519579e-02 | 1.186 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.519579e-02 | 1.186 |
| R-HSA-2262752 | Cellular responses to stress | 6.565329e-02 | 1.183 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 6.674109e-02 | 1.176 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 6.756905e-02 | 1.170 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 6.756905e-02 | 1.170 |
| R-HSA-111996 | Ca-dependent events | 6.997066e-02 | 1.155 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 7.476647e-02 | 1.126 |
| R-HSA-373752 | Netrin-1 signaling | 7.485634e-02 | 1.126 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 9.061224e-02 | 1.043 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.061886e-01 | 0.974 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.061886e-01 | 0.974 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.215000e-01 | 0.915 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 1.365509e-01 | 0.865 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.439801e-01 | 0.842 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 1.513459e-01 | 0.820 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 1.513459e-01 | 0.820 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.586487e-01 | 0.800 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.586487e-01 | 0.800 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.658891e-01 | 0.780 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.658891e-01 | 0.780 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.658891e-01 | 0.780 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 1.730676e-01 | 0.762 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.801848e-01 | 0.744 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.872412e-01 | 0.728 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 1.942373e-01 | 0.712 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.942373e-01 | 0.712 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.942373e-01 | 0.712 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.942373e-01 | 0.712 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.942373e-01 | 0.712 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.011736e-01 | 0.696 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.062196e-01 | 0.974 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.258711e-01 | 0.900 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.258711e-01 | 0.900 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.345413e-01 | 0.871 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.552573e-01 | 0.809 |
| R-HSA-380287 | Centrosome maturation | 1.612851e-01 | 0.792 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.826951e-01 | 0.738 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.107755e-01 | 0.676 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.283309e-01 | 0.641 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.982326e-01 | 0.703 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.513459e-01 | 0.820 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.439801e-01 | 0.842 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.658891e-01 | 0.780 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.730676e-01 | 0.762 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.872412e-01 | 0.728 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.080506e-01 | 0.682 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.148688e-01 | 0.668 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.658891e-01 | 0.780 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 7.733912e-02 | 1.112 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 9.638700e-02 | 1.016 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.148688e-01 | 0.668 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 9.807876e-02 | 1.008 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.866246e-01 | 0.729 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 9.843379e-02 | 1.007 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.374609e-01 | 0.862 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.145354e-01 | 0.941 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 9.061224e-02 | 1.043 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.290577e-01 | 0.889 |
| R-HSA-164378 | PKA activation in glucagon signalling | 1.801848e-01 | 0.744 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.283309e-01 | 0.641 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.796520e-02 | 1.056 |
| R-HSA-72766 | Translation | 1.946468e-01 | 0.711 |
| R-HSA-1500620 | Meiosis | 1.919968e-01 | 0.717 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.146545e-02 | 1.089 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.513459e-01 | 0.820 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.801848e-01 | 0.744 |
| R-HSA-912446 | Meiotic recombination | 9.275595e-02 | 1.033 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.522603e-01 | 0.817 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.215000e-01 | 0.915 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.215000e-01 | 0.915 |
| R-HSA-217271 | FMO oxidises nucleophiles | 1.215000e-01 | 0.915 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.365509e-01 | 0.865 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.632010e-02 | 1.064 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.888889e-01 | 0.724 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 8.493971e-02 | 1.071 |
| R-HSA-112040 | G-protein mediated events | 1.374609e-01 | 0.862 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 1.801848e-01 | 0.744 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.230121e-01 | 0.910 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.011736e-01 | 0.696 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.283309e-01 | 0.641 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.283309e-01 | 0.641 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 8.272332e-02 | 1.082 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.365509e-01 | 0.865 |
| R-HSA-163615 | PKA activation | 1.801848e-01 | 0.744 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.872412e-01 | 0.728 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.215000e-01 | 0.915 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.730676e-01 | 0.762 |
| R-HSA-9675135 | Diseases of DNA repair | 7.984768e-02 | 1.098 |
| R-HSA-8951664 | Neddylation | 1.563404e-01 | 0.806 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 8.272332e-02 | 1.082 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 9.061224e-02 | 1.043 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.439801e-01 | 0.842 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.513459e-01 | 0.820 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.730676e-01 | 0.762 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.730676e-01 | 0.762 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.942373e-01 | 0.712 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.658891e-01 | 0.780 |
| R-HSA-1226099 | Signaling by FGFR in disease | 1.582657e-01 | 0.801 |
| R-HSA-5576891 | Cardiac conduction | 1.350226e-01 | 0.870 |
| R-HSA-5358508 | Mismatch Repair | 1.801848e-01 | 0.744 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.919968e-01 | 0.717 |
| R-HSA-74160 | Gene expression (Transcription) | 1.933467e-01 | 0.714 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.730676e-01 | 0.762 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.730676e-01 | 0.762 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.216288e-01 | 0.654 |
| R-HSA-9609646 | HCMV Infection | 8.567859e-02 | 1.067 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.080506e-01 | 0.682 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.796099e-01 | 0.746 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.061886e-01 | 0.974 |
| R-HSA-168255 | Influenza Infection | 9.335159e-02 | 1.030 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.178579e-01 | 0.929 |
| R-HSA-210990 | PECAM1 interactions | 1.138771e-01 | 0.944 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.730676e-01 | 0.762 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.011736e-01 | 0.696 |
| R-HSA-73884 | Base Excision Repair | 2.107755e-01 | 0.676 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.383823e-02 | 1.028 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.011736e-01 | 0.696 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.011736e-01 | 0.696 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.468836e-02 | 1.072 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.468836e-02 | 1.072 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.843379e-02 | 1.007 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.612106e-01 | 0.793 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.872412e-01 | 0.728 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.062196e-01 | 0.974 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.061224e-02 | 1.043 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.069087e-01 | 0.971 |
| R-HSA-112043 | PLC beta mediated events | 1.201695e-01 | 0.920 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 2.011736e-01 | 0.696 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.857883e-01 | 0.731 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.678284e-01 | 0.775 |
| R-HSA-1181150 | Signaling by NODAL | 1.942373e-01 | 0.712 |
| R-HSA-983712 | Ion channel transport | 1.067174e-01 | 0.972 |
| R-HSA-1280218 | Adaptive Immune System | 7.780755e-02 | 1.109 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.062196e-01 | 0.974 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.148688e-01 | 0.668 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.089728e-01 | 0.963 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.779083e-01 | 0.750 |
| R-HSA-8983711 | OAS antiviral response | 1.290577e-01 | 0.889 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.730676e-01 | 0.762 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 1.872412e-01 | 0.728 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.230121e-01 | 0.910 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 1.522603e-01 | 0.817 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.785355e-02 | 1.109 |
| R-HSA-5663205 | Infectious disease | 1.527859e-01 | 0.816 |
| R-HSA-4839726 | Chromatin organization | 2.039590e-01 | 0.690 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.780355e-01 | 0.749 |
| R-HSA-1266738 | Developmental Biology | 8.078866e-02 | 1.093 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.216288e-01 | 0.654 |
| R-HSA-112316 | Neuronal System | 1.317630e-01 | 0.880 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.997062e-01 | 0.700 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.982326e-01 | 0.703 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.801848e-01 | 0.744 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.900973e-02 | 1.102 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.148688e-01 | 0.668 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.316361e-01 | 0.881 |
| R-HSA-422475 | Axon guidance | 1.179172e-01 | 0.928 |
| R-HSA-9675108 | Nervous system development | 1.517502e-01 | 0.819 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.982326e-01 | 0.703 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.108887e-01 | 0.955 |
| R-HSA-9830369 | Kidney development | 1.374609e-01 | 0.862 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.170773e-01 | 0.663 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.643151e-01 | 0.784 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.489337e-01 | 0.827 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.013599e-01 | 0.696 |
| R-HSA-449147 | Signaling by Interleukins | 1.963009e-01 | 0.707 |
| R-HSA-9679506 | SARS-CoV Infections | 2.309700e-01 | 0.636 |
| R-HSA-6798695 | Neutrophil degranulation | 2.327222e-01 | 0.633 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.349758e-01 | 0.629 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.349758e-01 | 0.629 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.349758e-01 | 0.629 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.355623e-01 | 0.628 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.392512e-01 | 0.621 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.415638e-01 | 0.617 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.415638e-01 | 0.617 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.415638e-01 | 0.617 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.415638e-01 | 0.617 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.415638e-01 | 0.617 |
| R-HSA-3295583 | TRP channels | 2.415638e-01 | 0.617 |
| R-HSA-70635 | Urea cycle | 2.415638e-01 | 0.617 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 2.415638e-01 | 0.617 |
| R-HSA-190236 | Signaling by FGFR | 2.424300e-01 | 0.615 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.456107e-01 | 0.610 |
| R-HSA-3214847 | HATs acetylate histones | 2.456107e-01 | 0.610 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.480956e-01 | 0.605 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.480956e-01 | 0.605 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.480956e-01 | 0.605 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.480956e-01 | 0.605 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.480956e-01 | 0.605 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.480956e-01 | 0.605 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.480956e-01 | 0.605 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.480956e-01 | 0.605 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.480956e-01 | 0.605 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.519769e-01 | 0.599 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.545714e-01 | 0.594 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.545714e-01 | 0.594 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.551618e-01 | 0.593 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.589961e-01 | 0.587 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.609919e-01 | 0.583 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 2.609919e-01 | 0.583 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.609919e-01 | 0.583 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.609919e-01 | 0.583 |
| R-HSA-111885 | Opioid Signalling | 2.615341e-01 | 0.582 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.673575e-01 | 0.573 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.673575e-01 | 0.573 |
| R-HSA-2424491 | DAP12 signaling | 2.673575e-01 | 0.573 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.673575e-01 | 0.573 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.673575e-01 | 0.573 |
| R-HSA-418346 | Platelet homeostasis | 2.710950e-01 | 0.567 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.710950e-01 | 0.567 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.736687e-01 | 0.563 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.736687e-01 | 0.563 |
| R-HSA-186763 | Downstream signal transduction | 2.736687e-01 | 0.563 |
| R-HSA-69239 | Synthesis of DNA | 2.742817e-01 | 0.562 |
| R-HSA-69190 | DNA strand elongation | 2.799258e-01 | 0.553 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.799258e-01 | 0.553 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.861295e-01 | 0.543 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.861295e-01 | 0.543 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.861295e-01 | 0.543 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.861295e-01 | 0.543 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.861295e-01 | 0.543 |
| R-HSA-159418 | Recycling of bile acids and salts | 2.861295e-01 | 0.543 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.861295e-01 | 0.543 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.894899e-01 | 0.538 |
| R-HSA-1483257 | Phospholipid metabolism | 2.894899e-01 | 0.538 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.902026e-01 | 0.537 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.902026e-01 | 0.537 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.902026e-01 | 0.537 |
| R-HSA-390522 | Striated Muscle Contraction | 2.922801e-01 | 0.534 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.922801e-01 | 0.534 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.922801e-01 | 0.534 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.922801e-01 | 0.534 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.922801e-01 | 0.534 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 2.922801e-01 | 0.534 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.922801e-01 | 0.534 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 2.922801e-01 | 0.534 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 2.922801e-01 | 0.534 |
| R-HSA-189483 | Heme degradation | 2.922801e-01 | 0.534 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.983780e-01 | 0.525 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.983780e-01 | 0.525 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.983780e-01 | 0.525 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.983780e-01 | 0.525 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.983780e-01 | 0.525 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.983780e-01 | 0.525 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.044238e-01 | 0.517 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.044238e-01 | 0.517 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.044238e-01 | 0.517 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.104179e-01 | 0.508 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.104179e-01 | 0.508 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.104179e-01 | 0.508 |
| R-HSA-9845576 | Glycosphingolipid transport | 3.104179e-01 | 0.508 |
| R-HSA-3371511 | HSF1 activation | 3.104179e-01 | 0.508 |
| R-HSA-8853659 | RET signaling | 3.104179e-01 | 0.508 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.124185e-01 | 0.505 |
| R-HSA-1296072 | Voltage gated Potassium channels | 3.163607e-01 | 0.500 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.163607e-01 | 0.500 |
| R-HSA-8953854 | Metabolism of RNA | 3.205008e-01 | 0.494 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.222526e-01 | 0.492 |
| R-HSA-3371556 | Cellular response to heat stress | 3.250519e-01 | 0.488 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.263834e-01 | 0.486 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.280942e-01 | 0.484 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.280942e-01 | 0.484 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.280942e-01 | 0.484 |
| R-HSA-201556 | Signaling by ALK | 3.280942e-01 | 0.484 |
| R-HSA-1643685 | Disease | 3.322475e-01 | 0.479 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.338857e-01 | 0.476 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.338857e-01 | 0.476 |
| R-HSA-167169 | HIV Transcription Elongation | 3.338857e-01 | 0.476 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.338857e-01 | 0.476 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.338857e-01 | 0.476 |
| R-HSA-202433 | Generation of second messenger molecules | 3.338857e-01 | 0.476 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.338857e-01 | 0.476 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.338857e-01 | 0.476 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.338857e-01 | 0.476 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.396277e-01 | 0.469 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.396277e-01 | 0.469 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.396277e-01 | 0.469 |
| R-HSA-9607240 | FLT3 Signaling | 3.396277e-01 | 0.469 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.438719e-01 | 0.464 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 3.438879e-01 | 0.464 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.453205e-01 | 0.462 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.453205e-01 | 0.462 |
| R-HSA-114608 | Platelet degranulation | 3.470118e-01 | 0.460 |
| R-HSA-991365 | Activation of GABAB receptors | 3.509646e-01 | 0.455 |
| R-HSA-977444 | GABA B receptor activation | 3.509646e-01 | 0.455 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.509646e-01 | 0.455 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.509646e-01 | 0.455 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.565604e-01 | 0.448 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.565604e-01 | 0.448 |
| R-HSA-162906 | HIV Infection | 3.592966e-01 | 0.445 |
| R-HSA-1474165 | Reproduction | 3.594580e-01 | 0.444 |
| R-HSA-2172127 | DAP12 interactions | 3.621083e-01 | 0.441 |
| R-HSA-69236 | G1 Phase | 3.621083e-01 | 0.441 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.621083e-01 | 0.441 |
| R-HSA-156581 | Methylation | 3.621083e-01 | 0.441 |
| R-HSA-9909396 | Circadian clock | 3.656494e-01 | 0.437 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.676087e-01 | 0.435 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.676087e-01 | 0.435 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.676087e-01 | 0.435 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.676087e-01 | 0.435 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.676087e-01 | 0.435 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.676087e-01 | 0.435 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 3.676087e-01 | 0.435 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.687366e-01 | 0.433 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.730620e-01 | 0.428 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.730620e-01 | 0.428 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.730620e-01 | 0.428 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.730620e-01 | 0.428 |
| R-HSA-75153 | Apoptotic execution phase | 3.730620e-01 | 0.428 |
| R-HSA-15869 | Metabolism of nucleotides | 3.803529e-01 | 0.420 |
| R-HSA-9634597 | GPER1 signaling | 3.838289e-01 | 0.416 |
| R-HSA-73893 | DNA Damage Bypass | 3.891434e-01 | 0.410 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.891434e-01 | 0.410 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.901785e-01 | 0.409 |
| R-HSA-109704 | PI3K Cascade | 3.944123e-01 | 0.404 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 3.944123e-01 | 0.404 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.946518e-01 | 0.404 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.022877e-01 | 0.395 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.048151e-01 | 0.393 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.048151e-01 | 0.393 |
| R-HSA-72187 | mRNA 3'-end processing | 4.048151e-01 | 0.393 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.048151e-01 | 0.393 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.048151e-01 | 0.393 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.048151e-01 | 0.393 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.099498e-01 | 0.387 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.099498e-01 | 0.387 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.099498e-01 | 0.387 |
| R-HSA-1221632 | Meiotic synapsis | 4.099498e-01 | 0.387 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.099498e-01 | 0.387 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.099498e-01 | 0.387 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.105449e-01 | 0.387 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.150405e-01 | 0.382 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.200876e-01 | 0.377 |
| R-HSA-418597 | G alpha (z) signalling events | 4.200876e-01 | 0.377 |
| R-HSA-69242 | S Phase | 4.202378e-01 | 0.377 |
| R-HSA-5688426 | Deubiquitination | 4.242689e-01 | 0.372 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.250915e-01 | 0.372 |
| R-HSA-177929 | Signaling by EGFR | 4.250915e-01 | 0.372 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.261611e-01 | 0.370 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.300525e-01 | 0.366 |
| R-HSA-112399 | IRS-mediated signalling | 4.300525e-01 | 0.366 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.320531e-01 | 0.364 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.349710e-01 | 0.362 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.349710e-01 | 0.362 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.349710e-01 | 0.362 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.398473e-01 | 0.357 |
| R-HSA-191859 | snRNP Assembly | 4.398473e-01 | 0.357 |
| R-HSA-186712 | Regulation of beta-cell development | 4.398473e-01 | 0.357 |
| R-HSA-180786 | Extension of Telomeres | 4.398473e-01 | 0.357 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.408311e-01 | 0.356 |
| R-HSA-977443 | GABA receptor activation | 4.446819e-01 | 0.352 |
| R-HSA-379724 | tRNA Aminoacylation | 4.446819e-01 | 0.352 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.446819e-01 | 0.352 |
| R-HSA-162587 | HIV Life Cycle | 4.466421e-01 | 0.350 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.494751e-01 | 0.347 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.494751e-01 | 0.347 |
| R-HSA-211976 | Endogenous sterols | 4.494751e-01 | 0.347 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.494751e-01 | 0.347 |
| R-HSA-445717 | Aquaporin-mediated transport | 4.494751e-01 | 0.347 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.537164e-01 | 0.343 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.542271e-01 | 0.343 |
| R-HSA-186797 | Signaling by PDGF | 4.542271e-01 | 0.343 |
| R-HSA-9707616 | Heme signaling | 4.542271e-01 | 0.343 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.542271e-01 | 0.343 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.552957e-01 | 0.342 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.589385e-01 | 0.338 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.589385e-01 | 0.338 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.619603e-01 | 0.335 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.636094e-01 | 0.334 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.636094e-01 | 0.334 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.667136e-01 | 0.331 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.671030e-01 | 0.331 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.682403e-01 | 0.330 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.682403e-01 | 0.330 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.728316e-01 | 0.325 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 4.773834e-01 | 0.321 |
| R-HSA-167172 | Transcription of the HIV genome | 4.818963e-01 | 0.317 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.818963e-01 | 0.317 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.818963e-01 | 0.317 |
| R-HSA-72306 | tRNA processing | 4.863531e-01 | 0.313 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.908062e-01 | 0.309 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.908062e-01 | 0.309 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.918824e-01 | 0.308 |
| R-HSA-212436 | Generic Transcription Pathway | 4.934537e-01 | 0.307 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 4.946330e-01 | 0.306 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 4.946330e-01 | 0.306 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.952040e-01 | 0.305 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.952040e-01 | 0.305 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.952040e-01 | 0.305 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.952040e-01 | 0.305 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.952040e-01 | 0.305 |
| R-HSA-189445 | Metabolism of porphyrins | 4.952040e-01 | 0.305 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.995640e-01 | 0.301 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.038867e-01 | 0.298 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.038867e-01 | 0.298 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.081723e-01 | 0.294 |
| R-HSA-917937 | Iron uptake and transport | 5.124211e-01 | 0.290 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.166335e-01 | 0.287 |
| R-HSA-5689603 | UCH proteinases | 5.166335e-01 | 0.287 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.208097e-01 | 0.283 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.249501e-01 | 0.280 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.249501e-01 | 0.280 |
| R-HSA-9659379 | Sensory processing of sound | 5.290551e-01 | 0.276 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.290551e-01 | 0.276 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.331247e-01 | 0.273 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.331247e-01 | 0.273 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.331247e-01 | 0.273 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.490573e-01 | 0.260 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.501825e-01 | 0.259 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.529553e-01 | 0.257 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.568199e-01 | 0.254 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 5.606514e-01 | 0.251 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.652552e-01 | 0.248 |
| R-HSA-156902 | Peptide chain elongation | 5.682158e-01 | 0.245 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.682158e-01 | 0.245 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.719494e-01 | 0.243 |
| R-HSA-72172 | mRNA Splicing | 5.775389e-01 | 0.238 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.793207e-01 | 0.237 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.829590e-01 | 0.234 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.865660e-01 | 0.232 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.865660e-01 | 0.232 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.901420e-01 | 0.229 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.936874e-01 | 0.226 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.972023e-01 | 0.224 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.006869e-01 | 0.221 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.006869e-01 | 0.221 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.041417e-01 | 0.219 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.041417e-01 | 0.219 |
| R-HSA-1296071 | Potassium Channels | 6.041417e-01 | 0.219 |
| R-HSA-157579 | Telomere Maintenance | 6.075668e-01 | 0.216 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.075668e-01 | 0.216 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.109624e-01 | 0.214 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.143289e-01 | 0.212 |
| R-HSA-70171 | Glycolysis | 6.176665e-01 | 0.209 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.209754e-01 | 0.207 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 6.275081e-01 | 0.202 |
| R-HSA-192823 | Viral mRNA Translation | 6.275081e-01 | 0.202 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.307324e-01 | 0.200 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.307324e-01 | 0.200 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.307324e-01 | 0.200 |
| R-HSA-382551 | Transport of small molecules | 6.401555e-01 | 0.194 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.428550e-01 | 0.192 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.433549e-01 | 0.192 |
| R-HSA-211000 | Gene Silencing by RNA | 6.433549e-01 | 0.192 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.464430e-01 | 0.189 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.464430e-01 | 0.189 |
| R-HSA-5419276 | Mitochondrial translation termination | 6.495046e-01 | 0.187 |
| R-HSA-202403 | TCR signaling | 6.525398e-01 | 0.185 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.525398e-01 | 0.185 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.585322e-01 | 0.181 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.644220e-01 | 0.178 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.702109e-01 | 0.174 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.730681e-01 | 0.172 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.730681e-01 | 0.172 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.730681e-01 | 0.172 |
| R-HSA-70326 | Glucose metabolism | 6.787089e-01 | 0.168 |
| R-HSA-68875 | Mitotic Prophase | 6.869894e-01 | 0.163 |
| R-HSA-73886 | Chromosome Maintenance | 6.897023e-01 | 0.161 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 6.897023e-01 | 0.161 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.903365e-01 | 0.161 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.950581e-01 | 0.158 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.977015e-01 | 0.156 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.029202e-01 | 0.153 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.029202e-01 | 0.153 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.029202e-01 | 0.153 |
| R-HSA-194138 | Signaling by VEGF | 7.029202e-01 | 0.153 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.105810e-01 | 0.148 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.155789e-01 | 0.145 |
| R-HSA-9843745 | Adipogenesis | 7.204911e-01 | 0.142 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.301032e-01 | 0.137 |
| R-HSA-446728 | Cell junction organization | 7.301032e-01 | 0.137 |
| R-HSA-163685 | Integration of energy metabolism | 7.347280e-01 | 0.134 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.351797e-01 | 0.134 |
| R-HSA-9658195 | Leishmania infection | 7.351797e-01 | 0.134 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.368539e-01 | 0.133 |
| R-HSA-5368287 | Mitochondrial translation | 7.393118e-01 | 0.131 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.393118e-01 | 0.131 |
| R-HSA-6807070 | PTEN Regulation | 7.415741e-01 | 0.130 |
| R-HSA-166520 | Signaling by NTRKs | 7.631522e-01 | 0.117 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.692696e-01 | 0.114 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.712737e-01 | 0.113 |
| R-HSA-1989781 | PPARA activates gene expression | 7.771828e-01 | 0.109 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.810378e-01 | 0.107 |
| R-HSA-9610379 | HCMV Late Events | 7.810378e-01 | 0.107 |
| R-HSA-9711097 | Cellular response to starvation | 7.829404e-01 | 0.106 |
| R-HSA-1500931 | Cell-Cell communication | 7.886484e-01 | 0.103 |
| R-HSA-109581 | Apoptosis | 7.903880e-01 | 0.102 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 7.993416e-01 | 0.097 |
| R-HSA-5619102 | SLC transporter disorders | 7.993416e-01 | 0.097 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.057897e-01 | 0.094 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.062303e-01 | 0.094 |
| R-HSA-418555 | G alpha (s) signalling events | 8.079154e-01 | 0.093 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.112422e-01 | 0.091 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.128841e-01 | 0.090 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.278843e-01 | 0.082 |
| R-HSA-168249 | Innate Immune System | 8.325262e-01 | 0.080 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.344354e-01 | 0.079 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.387226e-01 | 0.076 |
| R-HSA-211859 | Biological oxidations | 8.519048e-01 | 0.070 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.547967e-01 | 0.068 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.547967e-01 | 0.068 |
| R-HSA-5357801 | Programmed Cell Death | 8.585602e-01 | 0.066 |
| R-HSA-6805567 | Keratinization | 8.597930e-01 | 0.066 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.823266e-01 | 0.054 |
| R-HSA-418594 | G alpha (i) signalling events | 8.865969e-01 | 0.052 |
| R-HSA-72312 | rRNA processing | 8.883568e-01 | 0.051 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.931468e-01 | 0.049 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.950052e-01 | 0.048 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.021233e-01 | 0.045 |
| R-HSA-416476 | G alpha (q) signalling events | 9.156975e-01 | 0.038 |
| R-HSA-8957322 | Metabolism of steroids | 9.502906e-01 | 0.022 |
| R-HSA-388396 | GPCR downstream signalling | 9.700632e-01 | 0.013 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.725059e-01 | 0.012 |
| R-HSA-372790 | Signaling by GPCR | 9.831239e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.845593e-01 | 0.007 |
| R-HSA-556833 | Metabolism of lipids | 9.973532e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.996975e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999877e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.851 | 0.641 | 1 | 0.896 |
DYRK2 |
0.851 | 0.627 | 1 | 0.896 |
NLK |
0.850 | 0.637 | 1 | 0.824 |
CDK18 |
0.849 | 0.654 | 1 | 0.879 |
CDK8 |
0.849 | 0.622 | 1 | 0.885 |
KIS |
0.848 | 0.569 | 1 | 0.894 |
CDK19 |
0.847 | 0.614 | 1 | 0.885 |
CLK3 |
0.847 | 0.453 | 1 | 0.768 |
CDK5 |
0.846 | 0.638 | 1 | 0.879 |
CDK17 |
0.846 | 0.662 | 1 | 0.870 |
CDK7 |
0.845 | 0.616 | 1 | 0.887 |
P38G |
0.844 | 0.672 | 1 | 0.875 |
HIPK4 |
0.844 | 0.424 | 1 | 0.806 |
JNK2 |
0.843 | 0.672 | 1 | 0.895 |
ERK1 |
0.842 | 0.638 | 1 | 0.890 |
HIPK1 |
0.842 | 0.601 | 1 | 0.888 |
CDK1 |
0.841 | 0.626 | 1 | 0.882 |
CDK13 |
0.840 | 0.617 | 1 | 0.894 |
SRPK1 |
0.840 | 0.324 | -3 | 0.817 |
CDK14 |
0.840 | 0.652 | 1 | 0.885 |
CDK12 |
0.839 | 0.628 | 1 | 0.900 |
CDK3 |
0.839 | 0.591 | 1 | 0.869 |
HIPK3 |
0.839 | 0.588 | 1 | 0.888 |
CDK16 |
0.838 | 0.648 | 1 | 0.866 |
P38A |
0.838 | 0.623 | 1 | 0.882 |
CLK1 |
0.837 | 0.427 | -3 | 0.812 |
JNK3 |
0.837 | 0.652 | 1 | 0.898 |
DYRK1B |
0.836 | 0.602 | 1 | 0.903 |
CDK10 |
0.836 | 0.623 | 1 | 0.889 |
P38B |
0.836 | 0.634 | 1 | 0.880 |
ERK2 |
0.836 | 0.632 | 1 | 0.898 |
DYRK1A |
0.835 | 0.523 | 1 | 0.890 |
DYRK4 |
0.835 | 0.611 | 1 | 0.902 |
P38D |
0.834 | 0.655 | 1 | 0.890 |
DYRK3 |
0.834 | 0.526 | 1 | 0.878 |
ERK5 |
0.834 | 0.320 | 1 | 0.735 |
COT |
0.833 | 0.009 | 2 | 0.900 |
CDK9 |
0.833 | 0.606 | 1 | 0.900 |
CLK4 |
0.832 | 0.403 | -3 | 0.826 |
MTOR |
0.831 | 0.155 | 1 | 0.705 |
ICK |
0.830 | 0.340 | -3 | 0.880 |
CDKL5 |
0.830 | 0.198 | -3 | 0.845 |
CDKL1 |
0.830 | 0.192 | -3 | 0.848 |
SRPK2 |
0.829 | 0.275 | -3 | 0.742 |
NUAK2 |
0.827 | 0.130 | -3 | 0.881 |
PKCD |
0.825 | 0.131 | 2 | 0.838 |
CAMK1B |
0.825 | 0.099 | -3 | 0.893 |
PKN3 |
0.825 | 0.085 | -3 | 0.865 |
MST4 |
0.825 | 0.093 | 2 | 0.879 |
PKN2 |
0.824 | 0.095 | -3 | 0.872 |
CDK4 |
0.823 | 0.622 | 1 | 0.888 |
WNK1 |
0.823 | 0.047 | -2 | 0.888 |
PRKD2 |
0.823 | 0.116 | -3 | 0.841 |
CDK2 |
0.823 | 0.478 | 1 | 0.851 |
NEK6 |
0.823 | 0.026 | -2 | 0.848 |
SKMLCK |
0.822 | 0.113 | -2 | 0.896 |
CDK6 |
0.822 | 0.596 | 1 | 0.886 |
RSK2 |
0.821 | 0.101 | -3 | 0.841 |
AMPKA1 |
0.821 | 0.072 | -3 | 0.892 |
CLK2 |
0.820 | 0.385 | -3 | 0.817 |
PIM3 |
0.820 | 0.046 | -3 | 0.883 |
GCN2 |
0.820 | -0.144 | 2 | 0.797 |
RIPK3 |
0.819 | -0.022 | 3 | 0.763 |
ATR |
0.819 | 0.031 | 1 | 0.640 |
TBK1 |
0.819 | -0.115 | 1 | 0.534 |
MNK2 |
0.819 | 0.125 | -2 | 0.868 |
NUAK1 |
0.819 | 0.090 | -3 | 0.842 |
CAMLCK |
0.818 | 0.122 | -2 | 0.895 |
PRKD1 |
0.818 | 0.057 | -3 | 0.881 |
SRPK3 |
0.818 | 0.222 | -3 | 0.777 |
NDR1 |
0.818 | 0.037 | -3 | 0.882 |
NDR2 |
0.818 | 0.017 | -3 | 0.889 |
AMPKA2 |
0.818 | 0.079 | -3 | 0.872 |
NIK |
0.818 | 0.077 | -3 | 0.899 |
MAPKAPK3 |
0.817 | 0.055 | -3 | 0.836 |
TSSK1 |
0.817 | 0.089 | -3 | 0.914 |
AURC |
0.817 | 0.151 | -2 | 0.756 |
PRPK |
0.817 | -0.130 | -1 | 0.839 |
MAK |
0.817 | 0.451 | -2 | 0.751 |
MOS |
0.817 | -0.013 | 1 | 0.567 |
PHKG1 |
0.817 | 0.061 | -3 | 0.875 |
P90RSK |
0.817 | 0.077 | -3 | 0.841 |
TGFBR2 |
0.817 | -0.017 | -2 | 0.767 |
ULK2 |
0.817 | -0.134 | 2 | 0.812 |
RSK3 |
0.816 | 0.075 | -3 | 0.833 |
PKCA |
0.816 | 0.118 | 2 | 0.786 |
PRP4 |
0.816 | 0.425 | -3 | 0.838 |
PKCB |
0.816 | 0.105 | 2 | 0.807 |
RAF1 |
0.815 | -0.143 | 1 | 0.573 |
NEK7 |
0.815 | -0.088 | -3 | 0.813 |
PKACG |
0.815 | 0.092 | -2 | 0.811 |
PAK6 |
0.815 | 0.129 | -2 | 0.791 |
CDC7 |
0.815 | -0.125 | 1 | 0.527 |
P70S6KB |
0.814 | 0.088 | -3 | 0.848 |
MELK |
0.814 | 0.063 | -3 | 0.860 |
PIM1 |
0.814 | 0.099 | -3 | 0.835 |
DAPK2 |
0.814 | 0.096 | -3 | 0.898 |
WNK3 |
0.814 | -0.069 | 1 | 0.586 |
MARK4 |
0.814 | 0.009 | 4 | 0.745 |
MLK1 |
0.814 | -0.048 | 2 | 0.843 |
IKKB |
0.813 | -0.141 | -2 | 0.728 |
IKKE |
0.813 | -0.141 | 1 | 0.525 |
PDHK4 |
0.813 | -0.218 | 1 | 0.631 |
MNK1 |
0.813 | 0.118 | -2 | 0.864 |
BMPR2 |
0.813 | -0.139 | -2 | 0.863 |
PKCG |
0.813 | 0.089 | 2 | 0.798 |
IRE1 |
0.813 | -0.009 | 1 | 0.580 |
PKG2 |
0.812 | 0.133 | -2 | 0.766 |
PRKD3 |
0.812 | 0.093 | -3 | 0.812 |
CAMK4 |
0.811 | 0.030 | -3 | 0.859 |
MOK |
0.811 | 0.431 | 1 | 0.833 |
PKCH |
0.811 | 0.085 | 2 | 0.784 |
JNK1 |
0.811 | 0.563 | 1 | 0.873 |
TSSK2 |
0.811 | 0.034 | -5 | 0.796 |
DSTYK |
0.810 | -0.125 | 2 | 0.877 |
MLK3 |
0.810 | 0.042 | 2 | 0.791 |
PKCZ |
0.810 | 0.068 | 2 | 0.823 |
PAK3 |
0.809 | 0.052 | -2 | 0.853 |
QSK |
0.809 | 0.056 | 4 | 0.735 |
HUNK |
0.809 | -0.110 | 2 | 0.809 |
NIM1 |
0.809 | -0.022 | 3 | 0.796 |
PAK1 |
0.808 | 0.071 | -2 | 0.855 |
PDHK1 |
0.808 | -0.196 | 1 | 0.601 |
AURB |
0.808 | 0.125 | -2 | 0.758 |
SGK3 |
0.808 | 0.115 | -3 | 0.825 |
AKT2 |
0.808 | 0.141 | -3 | 0.760 |
QIK |
0.808 | 0.004 | -3 | 0.865 |
IRE2 |
0.807 | 0.002 | 2 | 0.802 |
PHKG2 |
0.807 | 0.066 | -3 | 0.851 |
NEK9 |
0.807 | -0.111 | 2 | 0.867 |
CAMK2G |
0.807 | -0.116 | 2 | 0.775 |
CHAK2 |
0.807 | -0.056 | -1 | 0.848 |
SIK |
0.807 | 0.052 | -3 | 0.814 |
CAMK2D |
0.807 | -0.045 | -3 | 0.876 |
LATS2 |
0.807 | -0.015 | -5 | 0.671 |
MAPKAPK2 |
0.806 | 0.043 | -3 | 0.799 |
MYLK4 |
0.806 | 0.103 | -2 | 0.842 |
ULK1 |
0.806 | -0.172 | -3 | 0.779 |
MSK2 |
0.805 | 0.059 | -3 | 0.801 |
PKACB |
0.805 | 0.136 | -2 | 0.776 |
MLK2 |
0.805 | -0.065 | 2 | 0.837 |
RIPK1 |
0.805 | -0.111 | 1 | 0.607 |
ANKRD3 |
0.805 | -0.081 | 1 | 0.614 |
PKR |
0.805 | 0.040 | 1 | 0.594 |
PKCT |
0.804 | 0.090 | 2 | 0.800 |
BCKDK |
0.804 | -0.141 | -1 | 0.771 |
AKT1 |
0.804 | 0.146 | -3 | 0.781 |
CAMK1G |
0.803 | 0.056 | -3 | 0.810 |
RSK4 |
0.802 | 0.082 | -3 | 0.814 |
ATM |
0.801 | -0.010 | 1 | 0.603 |
BRSK2 |
0.801 | -0.014 | -3 | 0.862 |
MASTL |
0.800 | -0.195 | -2 | 0.796 |
ERK7 |
0.800 | 0.202 | 2 | 0.541 |
PAK2 |
0.800 | 0.037 | -2 | 0.837 |
MARK3 |
0.799 | 0.022 | 4 | 0.709 |
MARK2 |
0.799 | 0.018 | 4 | 0.688 |
MSK1 |
0.799 | 0.080 | -3 | 0.806 |
NEK2 |
0.799 | -0.066 | 2 | 0.833 |
PRKX |
0.798 | 0.138 | -3 | 0.763 |
DCAMKL1 |
0.798 | 0.055 | -3 | 0.850 |
PKCE |
0.798 | 0.136 | 2 | 0.781 |
GRK5 |
0.798 | -0.197 | -3 | 0.827 |
TTBK2 |
0.798 | -0.182 | 2 | 0.734 |
BRSK1 |
0.798 | 0.003 | -3 | 0.847 |
PKCI |
0.798 | 0.083 | 2 | 0.793 |
VRK2 |
0.797 | 0.033 | 1 | 0.664 |
GRK1 |
0.797 | -0.049 | -2 | 0.716 |
WNK4 |
0.797 | -0.011 | -2 | 0.874 |
IKKA |
0.797 | -0.103 | -2 | 0.709 |
DLK |
0.797 | -0.199 | 1 | 0.584 |
PAK5 |
0.797 | 0.097 | -2 | 0.728 |
SMG1 |
0.796 | -0.011 | 1 | 0.618 |
PKN1 |
0.796 | 0.090 | -3 | 0.788 |
IRAK4 |
0.796 | -0.019 | 1 | 0.577 |
AURA |
0.796 | 0.099 | -2 | 0.737 |
PLK1 |
0.796 | -0.101 | -2 | 0.806 |
PIM2 |
0.796 | 0.082 | -3 | 0.807 |
MLK4 |
0.796 | -0.059 | 2 | 0.759 |
SMMLCK |
0.796 | 0.100 | -3 | 0.859 |
DNAPK |
0.795 | 0.002 | 1 | 0.620 |
LATS1 |
0.795 | 0.015 | -3 | 0.903 |
CHK1 |
0.795 | 0.011 | -3 | 0.869 |
CAMK2A |
0.795 | 0.001 | 2 | 0.746 |
MAPKAPK5 |
0.794 | -0.028 | -3 | 0.766 |
CAMK2B |
0.794 | -0.032 | 2 | 0.726 |
YSK4 |
0.794 | -0.116 | 1 | 0.552 |
GRK6 |
0.793 | -0.149 | 1 | 0.539 |
SNRK |
0.793 | -0.092 | 2 | 0.688 |
ALK4 |
0.793 | -0.054 | -2 | 0.801 |
SSTK |
0.793 | 0.039 | 4 | 0.738 |
MST3 |
0.793 | 0.046 | 2 | 0.865 |
CHAK1 |
0.793 | -0.108 | 2 | 0.781 |
PKACA |
0.793 | 0.120 | -2 | 0.729 |
PINK1 |
0.792 | 0.079 | 1 | 0.687 |
PAK4 |
0.791 | 0.095 | -2 | 0.740 |
DCAMKL2 |
0.791 | 0.020 | -3 | 0.867 |
MARK1 |
0.791 | -0.019 | 4 | 0.714 |
PLK4 |
0.791 | -0.091 | 2 | 0.651 |
AKT3 |
0.790 | 0.133 | -3 | 0.707 |
HRI |
0.790 | -0.111 | -2 | 0.819 |
GRK7 |
0.790 | -0.009 | 1 | 0.542 |
P70S6K |
0.790 | 0.043 | -3 | 0.768 |
CAMK1A |
0.790 | 0.106 | -3 | 0.729 |
MEKK1 |
0.789 | -0.091 | 1 | 0.590 |
NEK5 |
0.789 | -0.052 | 1 | 0.600 |
TGFBR1 |
0.788 | -0.046 | -2 | 0.772 |
CAMK1D |
0.788 | 0.070 | -3 | 0.758 |
PERK |
0.787 | -0.113 | -2 | 0.781 |
DRAK1 |
0.787 | -0.089 | 1 | 0.540 |
MEK1 |
0.787 | -0.179 | 2 | 0.809 |
MEK5 |
0.787 | -0.120 | 2 | 0.831 |
TAO3 |
0.787 | 0.021 | 1 | 0.600 |
GSK3A |
0.787 | 0.116 | 4 | 0.333 |
BMPR1B |
0.787 | -0.040 | 1 | 0.465 |
GRK4 |
0.786 | -0.215 | -2 | 0.774 |
MEKK2 |
0.786 | -0.065 | 2 | 0.827 |
TLK2 |
0.786 | -0.113 | 1 | 0.579 |
ZAK |
0.785 | -0.120 | 1 | 0.565 |
CHK2 |
0.785 | 0.084 | -3 | 0.713 |
MEKK3 |
0.785 | -0.133 | 1 | 0.592 |
MRCKB |
0.784 | 0.127 | -3 | 0.801 |
MPSK1 |
0.784 | 0.013 | 1 | 0.563 |
BUB1 |
0.783 | 0.110 | -5 | 0.768 |
PLK3 |
0.782 | -0.128 | 2 | 0.745 |
TAO2 |
0.782 | 0.014 | 2 | 0.880 |
SGK1 |
0.782 | 0.122 | -3 | 0.689 |
NEK8 |
0.782 | -0.065 | 2 | 0.848 |
ACVR2A |
0.782 | -0.095 | -2 | 0.750 |
DAPK3 |
0.782 | 0.097 | -3 | 0.855 |
PDK1 |
0.782 | 0.007 | 1 | 0.623 |
NEK11 |
0.780 | -0.088 | 1 | 0.608 |
ROCK2 |
0.779 | 0.120 | -3 | 0.847 |
TLK1 |
0.779 | -0.129 | -2 | 0.798 |
ACVR2B |
0.779 | -0.105 | -2 | 0.761 |
PKG1 |
0.779 | 0.094 | -2 | 0.699 |
BRAF |
0.778 | -0.144 | -4 | 0.809 |
GSK3B |
0.778 | -0.014 | 4 | 0.328 |
TTBK1 |
0.777 | -0.164 | 2 | 0.660 |
MRCKA |
0.776 | 0.090 | -3 | 0.814 |
ALK2 |
0.776 | -0.100 | -2 | 0.774 |
SBK |
0.776 | 0.154 | -3 | 0.652 |
GRK2 |
0.776 | -0.110 | -2 | 0.682 |
MEKK6 |
0.776 | -0.047 | 1 | 0.582 |
FAM20C |
0.775 | -0.094 | 2 | 0.483 |
MAP3K15 |
0.775 | -0.053 | 1 | 0.580 |
TNIK |
0.775 | 0.016 | 3 | 0.837 |
VRK1 |
0.775 | -0.025 | 2 | 0.886 |
GAK |
0.775 | -0.020 | 1 | 0.563 |
NEK4 |
0.774 | -0.106 | 1 | 0.577 |
IRAK1 |
0.774 | -0.194 | -1 | 0.747 |
LKB1 |
0.774 | -0.049 | -3 | 0.844 |
DMPK1 |
0.773 | 0.149 | -3 | 0.820 |
HGK |
0.773 | -0.035 | 3 | 0.836 |
LOK |
0.773 | -0.017 | -2 | 0.774 |
GCK |
0.773 | -0.030 | 1 | 0.574 |
NEK1 |
0.773 | -0.050 | 1 | 0.577 |
DAPK1 |
0.773 | 0.068 | -3 | 0.838 |
HASPIN |
0.773 | 0.061 | -1 | 0.688 |
PASK |
0.772 | -0.055 | -3 | 0.890 |
YSK1 |
0.772 | -0.018 | 2 | 0.849 |
EEF2K |
0.771 | -0.045 | 3 | 0.804 |
CK1E |
0.771 | -0.072 | -3 | 0.495 |
HPK1 |
0.770 | -0.028 | 1 | 0.580 |
LRRK2 |
0.769 | -0.030 | 2 | 0.856 |
KHS1 |
0.769 | 0.003 | 1 | 0.574 |
MST2 |
0.769 | -0.082 | 1 | 0.570 |
ROCK1 |
0.768 | 0.110 | -3 | 0.814 |
MINK |
0.768 | -0.083 | 1 | 0.563 |
RIPK2 |
0.768 | -0.163 | 1 | 0.555 |
BMPR1A |
0.768 | -0.063 | 1 | 0.442 |
KHS2 |
0.768 | 0.024 | 1 | 0.582 |
CAMKK2 |
0.765 | -0.149 | -2 | 0.733 |
NEK3 |
0.765 | -0.075 | 1 | 0.590 |
TAK1 |
0.765 | -0.110 | 1 | 0.555 |
CRIK |
0.764 | 0.088 | -3 | 0.774 |
SLK |
0.764 | -0.060 | -2 | 0.693 |
CAMKK1 |
0.764 | -0.221 | -2 | 0.737 |
CK1G1 |
0.763 | -0.113 | -3 | 0.487 |
MST1 |
0.762 | -0.087 | 1 | 0.563 |
CK1D |
0.762 | -0.058 | -3 | 0.438 |
CK1A2 |
0.761 | -0.065 | -3 | 0.440 |
PBK |
0.760 | -0.043 | 1 | 0.509 |
TAO1 |
0.760 | -0.005 | 1 | 0.572 |
GRK3 |
0.760 | -0.115 | -2 | 0.633 |
STK33 |
0.759 | -0.141 | 2 | 0.622 |
MYO3B |
0.758 | 0.013 | 2 | 0.847 |
LIMK2_TYR |
0.757 | 0.159 | -3 | 0.906 |
TTK |
0.757 | -0.021 | -2 | 0.801 |
OSR1 |
0.755 | -0.056 | 2 | 0.807 |
PDHK3_TYR |
0.754 | 0.063 | 4 | 0.746 |
BIKE |
0.754 | -0.017 | 1 | 0.480 |
MEK2 |
0.753 | -0.224 | 2 | 0.808 |
TESK1_TYR |
0.753 | 0.042 | 3 | 0.871 |
MYO3A |
0.753 | -0.013 | 1 | 0.589 |
CK2A2 |
0.751 | -0.067 | 1 | 0.370 |
PLK2 |
0.751 | -0.103 | -3 | 0.765 |
ASK1 |
0.751 | -0.100 | 1 | 0.569 |
PKMYT1_TYR |
0.751 | 0.072 | 3 | 0.850 |
RET |
0.749 | -0.035 | 1 | 0.602 |
MAP2K7_TYR |
0.748 | -0.081 | 2 | 0.846 |
PINK1_TYR |
0.748 | -0.048 | 1 | 0.615 |
MST1R |
0.747 | -0.028 | 3 | 0.829 |
LIMK1_TYR |
0.746 | 0.023 | 2 | 0.858 |
PDHK4_TYR |
0.745 | -0.007 | 2 | 0.853 |
AAK1 |
0.745 | 0.017 | 1 | 0.424 |
TYK2 |
0.744 | -0.097 | 1 | 0.587 |
JAK1 |
0.744 | 0.012 | 1 | 0.581 |
MAP2K4_TYR |
0.744 | -0.105 | -1 | 0.849 |
JAK2 |
0.744 | -0.058 | 1 | 0.597 |
ROS1 |
0.743 | -0.042 | 3 | 0.798 |
CSF1R |
0.742 | -0.048 | 3 | 0.817 |
BMPR2_TYR |
0.742 | -0.020 | -1 | 0.849 |
EPHA6 |
0.742 | -0.030 | -1 | 0.867 |
TYRO3 |
0.742 | -0.085 | 3 | 0.819 |
TNK1 |
0.741 | 0.008 | 3 | 0.801 |
MAP2K6_TYR |
0.741 | -0.088 | -1 | 0.855 |
JAK3 |
0.740 | -0.049 | 1 | 0.600 |
DDR1 |
0.740 | -0.060 | 4 | 0.706 |
CK2A1 |
0.740 | -0.091 | 1 | 0.356 |
PDHK1_TYR |
0.739 | -0.106 | -1 | 0.879 |
TNNI3K_TYR |
0.738 | 0.019 | 1 | 0.588 |
ABL2 |
0.738 | -0.046 | -1 | 0.818 |
KDR |
0.738 | -0.018 | 3 | 0.778 |
EPHB4 |
0.737 | -0.089 | -1 | 0.850 |
NEK10_TYR |
0.737 | -0.055 | 1 | 0.534 |
YANK3 |
0.734 | -0.090 | 2 | 0.402 |
TNK2 |
0.734 | -0.065 | 3 | 0.788 |
PDGFRB |
0.733 | -0.123 | 3 | 0.827 |
FGFR2 |
0.733 | -0.060 | 3 | 0.805 |
ABL1 |
0.733 | -0.069 | -1 | 0.809 |
STLK3 |
0.732 | -0.186 | 1 | 0.547 |
FGFR1 |
0.732 | -0.042 | 3 | 0.793 |
LCK |
0.732 | -0.033 | -1 | 0.844 |
FLT3 |
0.732 | -0.109 | 3 | 0.806 |
YES1 |
0.732 | -0.086 | -1 | 0.855 |
ALPHAK3 |
0.732 | -0.132 | -1 | 0.763 |
TEK |
0.731 | -0.036 | 3 | 0.764 |
WEE1_TYR |
0.731 | -0.037 | -1 | 0.744 |
KIT |
0.731 | -0.103 | 3 | 0.815 |
TXK |
0.730 | -0.042 | 1 | 0.482 |
FGR |
0.730 | -0.137 | 1 | 0.533 |
HCK |
0.730 | -0.096 | -1 | 0.841 |
INSRR |
0.729 | -0.118 | 3 | 0.781 |
BLK |
0.729 | -0.026 | -1 | 0.859 |
PDGFRA |
0.729 | -0.141 | 3 | 0.829 |
DDR2 |
0.728 | 0.008 | 3 | 0.767 |
ITK |
0.727 | -0.093 | -1 | 0.811 |
EPHB1 |
0.727 | -0.132 | 1 | 0.542 |
ALK |
0.727 | -0.092 | 3 | 0.762 |
AXL |
0.726 | -0.133 | 3 | 0.801 |
MET |
0.726 | -0.095 | 3 | 0.810 |
TEC |
0.725 | -0.083 | -1 | 0.766 |
FER |
0.725 | -0.180 | 1 | 0.530 |
EPHB3 |
0.725 | -0.128 | -1 | 0.847 |
FRK |
0.724 | -0.084 | -1 | 0.870 |
LTK |
0.723 | -0.118 | 3 | 0.773 |
MERTK |
0.722 | -0.127 | 3 | 0.795 |
BTK |
0.722 | -0.162 | -1 | 0.786 |
EPHA4 |
0.722 | -0.121 | 2 | 0.727 |
EPHA1 |
0.722 | -0.108 | 3 | 0.788 |
BMX |
0.721 | -0.096 | -1 | 0.745 |
EPHB2 |
0.721 | -0.132 | -1 | 0.834 |
FLT1 |
0.721 | -0.103 | -1 | 0.823 |
SRMS |
0.721 | -0.175 | 1 | 0.515 |
FGFR3 |
0.721 | -0.082 | 3 | 0.784 |
FLT4 |
0.720 | -0.128 | 3 | 0.766 |
CK1A |
0.718 | -0.104 | -3 | 0.344 |
EPHA7 |
0.718 | -0.113 | 2 | 0.745 |
NTRK2 |
0.718 | -0.174 | 3 | 0.781 |
PTK6 |
0.717 | -0.187 | -1 | 0.736 |
INSR |
0.717 | -0.148 | 3 | 0.756 |
FYN |
0.717 | -0.071 | -1 | 0.822 |
ERBB2 |
0.716 | -0.166 | 1 | 0.530 |
MUSK |
0.715 | -0.092 | 1 | 0.475 |
NTRK1 |
0.715 | -0.214 | -1 | 0.798 |
LYN |
0.714 | -0.118 | 3 | 0.736 |
MATK |
0.711 | -0.119 | -1 | 0.752 |
NTRK3 |
0.711 | -0.160 | -1 | 0.760 |
EPHA3 |
0.711 | -0.169 | 2 | 0.719 |
PTK2B |
0.711 | -0.103 | -1 | 0.787 |
EPHA8 |
0.709 | -0.112 | -1 | 0.842 |
EGFR |
0.708 | -0.119 | 1 | 0.467 |
SRC |
0.708 | -0.118 | -1 | 0.823 |
CSK |
0.706 | -0.164 | 2 | 0.748 |
EPHA5 |
0.704 | -0.158 | 2 | 0.716 |
FGFR4 |
0.704 | -0.129 | -1 | 0.768 |
CK1G3 |
0.703 | -0.097 | -3 | 0.295 |
IGF1R |
0.698 | -0.162 | 3 | 0.697 |
EPHA2 |
0.697 | -0.135 | -1 | 0.788 |
PTK2 |
0.697 | -0.077 | -1 | 0.770 |
YANK2 |
0.697 | -0.123 | 2 | 0.401 |
SYK |
0.694 | -0.104 | -1 | 0.777 |
ERBB4 |
0.693 | -0.110 | 1 | 0.448 |
FES |
0.686 | -0.152 | -1 | 0.716 |
ZAP70 |
0.680 | -0.091 | -1 | 0.687 |
CK1G2 |
0.679 | -0.110 | -3 | 0.396 |