Motif 349 (n=233)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYC7 | ZFP91-CNTF | S82 | ochoa | E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 91 homolog) | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000256|ARBA:ARBA00054990}. |
| A7XYQ1 | SOBP | S629 | ochoa | Sine oculis-binding protein homolog (Jackson circler protein 1) | Implicated in development of the cochlea. {ECO:0000250|UniProtKB:Q0P5V2}. |
| A8MSY1 | STIMATE-MUSTN1 | S249 | ochoa | Musculoskeletal embryonic nuclear protein 1 | None |
| A8MVW0 | FAM171A2 | S424 | ochoa | Protein FAM171A2 | None |
| D6RIA3 | C4orf54 | S1035 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| E7EW31 | PROB1 | S372 | ochoa | Proline-rich basic protein 1 | None |
| O00170 | AIP | S131 | psp | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O00231 | PSMD11 | S23 | ochoa | 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}. |
| O00273 | DFFA | S28 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O00425 | IGF2BP3 | S184 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O14579 | COPE | S109 | ochoa | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| O14681 | EI24 | S56 | ochoa | Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) | Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}. |
| O14813 | PHOX2A | S153 | psp | Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) | May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. |
| O15069 | NACAD | S1130 | ochoa | NAC-alpha domain-containing protein 1 | May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
| O15085 | ARHGEF11 | S635 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O43295 | SRGAP3 | S1030 | ochoa | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}. |
| O43439 | CBFA2T2 | S409 | ochoa | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| O43683 | BUB1 | S563 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60318 | MCM3AP | S422 | ochoa | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}. |
| O60716 | CTNND1 | S252 | ochoa|psp | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O95071 | UBR5 | S2369 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95171 | SCEL | S91 | ochoa | Sciellin | May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
| O95425 | SVIL | S644 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95571 | ETHE1 | S19 | ochoa | Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Ethylmalonic encephalopathy protein 1) (Hepatoma subtracted clone one protein) (Sulfur dioxygenase ETHE1) | Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897). {ECO:0000269|PubMed:12398897, ECO:0000269|PubMed:14732903, ECO:0000269|PubMed:19136963, ECO:0000269|PubMed:23144459}. |
| P03372 | ESR1 | S154 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04920 | SLC4A2 | S243 | ochoa | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
| P05164 | MPO | S92 | ochoa | Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971). {ECO:0000269|PubMed:25698971, ECO:0000269|PubMed:9922160}. |
| P05164 | MPO | S231 | ochoa | Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971). {ECO:0000269|PubMed:25698971, ECO:0000269|PubMed:9922160}. |
| P05423 | POLR3D | S42 | ochoa | DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P25441, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}. |
| P07384 | CAPN1 | S474 | ochoa | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| P07919 | UQCRH | S59 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
| P08151 | GLI1 | S84 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P08151 | GLI1 | S408 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P09603 | CSF1 | S533 | ochoa | Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit] | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:8051056}. |
| P10070 | GLI2 | S234 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10275 | AR | S792 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P13631 | RARG | S390 | psp | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}. |
| P15976 | GATA1 | S310 | psp | Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) | Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}. |
| P18583 | SON | S1747 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19086 | GNAZ | S27 | psp | Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. |
| P23193 | TCEA1 | S135 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P35568 | IRS1 | S1101 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P39880 | CUX1 | S652 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P40337 | VHL | S72 | ochoa|psp | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}. |
| P41586 | ADCYAP1R1 | S434 | ochoa | Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) | G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides (PubMed:32047270, PubMed:35477937, PubMed:36385145). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (PubMed:32047270, PubMed:33715378). {ECO:0000269|PubMed:32047270, ECO:0000269|PubMed:33715378, ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145}. |
| P46087 | NOP2 | S58 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P53814 | SMTN | S523 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P55196 | AFDN | S589 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P57078 | RIPK4 | S444 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
| P62854 | RPS26 | S54 | ochoa | Small ribosomal subunit protein eS26 (40S ribosomal protein S26) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}. |
| P78314 | SH3BP2 | S427 | ochoa | SH3 domain-binding protein 2 (3BP-2) | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. |
| P78411 | IRX5 | S387 | ochoa | Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5) | Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}. |
| Q00013 | MPP1 | S110 | ochoa | 55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}. |
| Q00266 | MAT1A | S180 | psp | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10677294}. |
| Q01201 | RELB | S151 | ochoa | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q01813 | PFKP | S386 | ochoa|psp | ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| Q02078 | MEF2A | S201 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q02543 | RPL18A | S86 | ochoa | Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q02543 | RPL18A | S123 | ochoa | Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q02833 | RASSF7 | S97 | ochoa | Ras association domain-containing protein 7 (HRAS1-related cluster protein 1) | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. {ECO:0000269|PubMed:20629633, ECO:0000269|PubMed:21278800}. |
| Q03001 | DST | S7416 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q04206 | RELA | S45 | ochoa|psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q04864 | REL | S34 | ochoa | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Q08AD1 | CAMSAP2 | S464 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S135 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12802 | AKAP13 | S1876 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12933 | TRAF2 | S55 | psp | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:10346818, PubMed:11784851, PubMed:12917689, PubMed:15383523, PubMed:18981220, PubMed:19150425, PubMed:19810754, PubMed:19918265, PubMed:19937093, PubMed:20047764, PubMed:20064526, PubMed:20385093, PubMed:20577214, PubMed:22212761). Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1 (PubMed:23453969, PubMed:28489822). Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases (PubMed:15383523, PubMed:18981220). Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain (PubMed:11907583, PubMed:19506082). Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR (PubMed:15121867). In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE (PubMed:23453969). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex (PubMed:28489822). Required for normal antibody isotype switching from IgM to IgG (By similarity). {ECO:0000250|UniProtKB:P39429, ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, ECO:0000269|PubMed:19150425, ECO:0000269|PubMed:19506082, ECO:0000269|PubMed:19810754, ECO:0000269|PubMed:19918265, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20047764, ECO:0000269|PubMed:20064526, ECO:0000269|PubMed:20385093, ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:22212761, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:28489822}. |
| Q13009 | TIAM1 | S224 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13573 | SNW1 | S389 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13671 | RIN1 | S292 | ochoa|psp | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14161 | GIT2 | S154 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14432 | PDE3A | S439 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14684 | RRP1B | S661 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14C86 | GAPVD1 | S902 | psp | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}. |
| Q15036 | SNX17 | S409 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15058 | KIF14 | S1200 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15717 | ELAVL1 | S88 | psp | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q15772 | SPEG | S2110 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15773 | MLF2 | S216 | ochoa | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | None |
| Q15814 | TBCC | S80 | ochoa | Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC) | Tubulin-folding protein; involved in the final step of the tubulin folding pathway. {ECO:0000269|PubMed:11847227}. |
| Q16206 | ENOX2 | S240 | ochoa | Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] | May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}. |
| Q16630 | CPSF6 | S434 | ochoa | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, PubMed:8626397, PubMed:9659921). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:14690600, PubMed:8626397, PubMed:9659921). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:21295486, PubMed:29276085). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}. |
| Q16825 | PTPN21 | S820 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q1W6H9 | FAM110C | S99 | ochoa | Protein FAM110C | May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. |
| Q4KWH8 | PLCH1 | S970 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q4VX76 | SYTL3 | S231 | ochoa | Synaptotagmin-like protein 3 (Exophilin-6) | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). {ECO:0000250}. |
| Q5HYK7 | SH3D19 | S369 | ochoa | SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) | May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:14551139, ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. |
| Q5JS13 | RALGPS1 | S297 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) | Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for. {ECO:0000250, ECO:0000269|PubMed:10747847, ECO:0000269|PubMed:10889189}. |
| Q5SQ64 | LY6G6F | S270 | ochoa | Lymphocyte antigen 6 complex locus protein G6f | May play a role in the downstream signal transduction pathways involving GRB2 and GRB7. {ECO:0000269|PubMed:12852788}. |
| Q5SW79 | CEP170 | S1270 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T3J3 | LRIF1 | S502 | ochoa | Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1) | Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133). {ECO:0000269|PubMed:17455211, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:32467133}. |
| Q5TCZ1 | SH3PXD2A | S981 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VST9 | OBSCN | S4076 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q6DT37 | CDC42BPG | S1482 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6F5E8 | CARMIL2 | S1355 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6F5E8 | CARMIL2 | S1362 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6JBY9 | RCSD1 | S179 | ochoa|psp | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6NT76 | HMBOX1 | S148 | ochoa | Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1) | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23685356, PubMed:23813958). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). {ECO:0000250|UniProtKB:Q8BJA3, ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}. |
| Q6NY19 | KANK3 | S271 | ochoa | KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. |
| Q6X4W1 | NSMF | S164 | ochoa | NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor) | Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269|PubMed:20025934}. |
| Q6ZMT1 | STAC2 | S48 | ochoa | SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) | Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}. |
| Q6ZN28 | MACC1 | S139 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q6ZN55 | ZNF574 | S298 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZNL6 | FGD5 | S1317 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZP65 | BICDL1 | S551 | ochoa | BICD family-like cargo adapter 1 (Bicaudal D-related protein 1) (BICD-related protein 1) (BICDR-1) (Coiled-coil domain-containing protein 64A) (CCDC64A) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis. {ECO:0000250|UniProtKB:A0JNT9}. |
| Q6ZSZ5 | ARHGEF18 | S94 | ochoa | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. |
| Q6ZUT1 | NKAPD1 | S61 | ochoa | Uncharacterized protein NKAPD1 (NKAP domain containing protein 1) | None |
| Q70E73 | RAPH1 | S1183 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q70EL4 | USP43 | S796 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q71H61 | ILDR2 | S547 | ochoa | Immunoglobulin-like domain-containing receptor 2 (Angulin-3) | May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}. |
| Q7L590 | MCM10 | S824 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z3D4 | LYSMD3 | S55 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 3 | Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}. |
| Q7Z3G6 | PRICKLE2 | S753 | ochoa | Prickle-like protein 2 | None |
| Q86TL2 | STIMATE | S249 | ochoa | Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. |
| Q86US8 | SMG6 | S258 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86VP3 | PACS2 | S453 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
| Q86X51 | EZHIP | S338 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86YV0 | RASAL3 | S51 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IV36 | HID1 | S593 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IVF2 | AHNAK2 | S332 | ochoa | Protein AHNAK2 | None |
| Q8IWA4 | MFN1 | S86 | psp | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). {ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}. |
| Q8IY63 | AMOTL1 | S241 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IY92 | SLX4 | S1244 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N1G0 | ZNF687 | S1083 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N283 | ANKRD35 | S881 | ochoa | Ankyrin repeat domain-containing protein 35 | None |
| Q8N4C8 | MINK1 | S993 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N5F7 | NKAP | S80 | ochoa | NF-kappa-B-activating protein | Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}. |
| Q8N612 | FHIP1B | S859 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8N684 | CPSF7 | S191 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8NFW9 | MYRIP | S534 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8NHM5 | KDM2B | S951 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8NHQ8 | RASSF8 | S90 | ochoa | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | None |
| Q8NHY2 | COP1 | S387 | psp | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). {ECO:0000269|PubMed:12466024, ECO:0000269|PubMed:12615916, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15103385, ECO:0000269|PubMed:19805145, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21625211, ECO:0000303|PubMed:27041596}. |
| Q8TAA9 | VANGL1 | S338 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TBE0 | BAHD1 | S206 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TBP0 | TBC1D16 | S118 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TC07 | TBC1D15 | S274 | ochoa | TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) | Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}. |
| Q8TC92 | ENOX1 | S254 | ochoa | Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] | Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:11360993, ECO:0000269|PubMed:12565167, ECO:0000269|PubMed:17027975, ECO:0000269|PubMed:19055324}. |
| Q8TCN5 | ZNF507 | S494 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TE68 | EPS8L1 | S118 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TF01 | PNISR | S211 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WWI1 | LMO7 | S910 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92599 | SEPTIN8 | S20 | ochoa | Septin-8 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}. |
| Q92733 | PRCC | S209 | ochoa | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q92766 | RREB1 | S1167 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92805 | GOLGA1 | S30 | ochoa | Golgin subfamily A member 1 (Golgin-97) | Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23 (PubMed:29084197, PubMed:38552021). Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers (PubMed:34969853). {ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:38552021}.; FUNCTION: (Microbial infection) Plays an important role in poxvirus morphogenesis. Translocates into the viral factories where it may transport the membrane fragments and associated protein factors important for virus maturation to the sites of virion assembly. {ECO:0000269|PubMed:17276477}. |
| Q92953 | KCNB2 | S448 | ochoa | Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. {ECO:0000250|UniProtKB:A6H8H5, ECO:0000250|UniProtKB:Q63099}. |
| Q96CM8 | ACSF2 | S52 | ochoa | Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2) | Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219). {ECO:0000269|PubMed:16380219, ECO:0000269|PubMed:17762044}. |
| Q96G42 | KLHDC7B | S134 | ochoa | Kelch domain-containing protein 7B | None |
| Q96G46 | DUS3L | S236 | ochoa | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) | Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860). {ECO:0000269|PubMed:34556860}. |
| Q96JN8 | NEURL4 | S502 | ochoa | Neuralized-like protein 4 | Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. |
| Q96JP5 | ZFP91 | S82 | ochoa | E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91) | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}. |
| Q96JZ2 | HSH2D | S298 | ochoa | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
| Q96P48 | ARAP1 | S1419 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q4LDD4, ECO:0000269|PubMed:11804590, ECO:0000269|PubMed:18764928, ECO:0000269|PubMed:18939958, ECO:0000269|PubMed:19666464, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:22573888, ECO:0000269|PubMed:38682696}. |
| Q96PE2 | ARHGEF17 | S420 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PE2 | ARHGEF17 | S961 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96S99 | PLEKHF1 | S142 | ochoa | Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15) | May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}. |
| Q99569 | PKP4 | S290 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q9BRA0 | NAA38 | S23 | ochoa | N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1) (Phosphonoformate immuno-associated protein 2) | Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q9BRD0 | BUD13 | S296 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BTL4 | IER2 | S126 | ochoa | Immediate early response gene 2 protein (Protein ETR101) | DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). {ECO:0000250|UniProtKB:B7SXM5, ECO:0000250|UniProtKB:Q6P7D3, ECO:0000269|PubMed:19584537, ECO:0000269|PubMed:22120713}. |
| Q9BX66 | SORBS1 | S506 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BY89 | KIAA1671 | S633 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZ72 | PITPNM2 | S1277 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9BZF3 | OSBPL6 | S195 | ochoa | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. |
| Q9C0B5 | ZDHHC5 | S529 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | S1554 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZY6 | LAT2 | S106 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9GZY8 | MFF | S157 | ochoa|psp | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H165 | BCL11A | S608 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9H1Z4 | WDR13 | S113 | ochoa | WD repeat-containing protein 13 | None |
| Q9H2G2 | SLK | S1094 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2S9 | IKZF4 | S238 | ochoa | Zinc finger protein Eos (Ikaros family zinc finger protein 4) | DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}. |
| Q9H4G0 | EPB41L1 | S441 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H4G0 | EPB41L1 | S540 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H6K5 | PRR36 | S165 | ochoa | Proline-rich protein 36 | None |
| Q9H773 | DCTPP1 | S138 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
| Q9H7E9 | C8orf33 | S39 | ochoa | UPF0488 protein C8orf33 | None |
| Q9H981 | ACTR8 | S468 | ochoa | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. |
| Q9HAU0 | PLEKHA5 | S471 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HCD5 | NCOA5 | S126 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9NQT8 | KIF13B | S1778 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NQU5 | PAK6 | S113 | ochoa|psp | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| Q9NR09 | BIRC6 | S1866 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NS56 | TOPORS | S735 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NS62 | THSD1 | S453 | ochoa | Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) | Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}. |
| Q9NWH9 | SLTM | S909 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NWZ8 | GEMIN8 | S170 | ochoa | Gem-associated protein 8 (Gemin-8) (Protein FAM51A1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}. |
| Q9NY61 | AATF | S510 | psp | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9P203 | BTBD7 | S966 | ochoa | BTB/POZ domain-containing protein 7 | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}. |
| Q9P2B4 | CTTNBP2NL | S514 | ochoa | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9P2E9 | RRBP1 | S959 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2F8 | SIPA1L2 | S284 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBL0 | ARPP21 | S280 | ochoa | cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) | Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}. |
| Q9UBW8 | COPS7A | S255 | ochoa | COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q9UGI0 | ZRANB1 | S115 | ochoa | Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1) | Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Required in the stress fiber dynamics and cell migration (PubMed:21834987). {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:33637724}. |
| Q9UGI9 | PRKAG3 | S65 | ochoa | 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:17878938, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism (PubMed:17878938). It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:17878938, ECO:0000269|PubMed:24563466}. |
| Q9UJA3 | MCM8 | S630 | ochoa | DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093). {ECO:0000250|UniProtKB:Q9CWV1, ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}. |
| Q9UK39 | NOCT | S33 | ochoa | Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) | Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). {ECO:0000250|UniProtKB:O35710, ECO:0000269|PubMed:29860338, ECO:0000269|PubMed:31147539}. |
| Q9UKA4 | AKAP11 | S613 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKT9 | IKZF3 | S115 | ochoa | Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:34155405}. |
| Q9UL54 | TAOK2 | S473 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9ULD2 | MTUS1 | S761 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULT8 | HECTD1 | S1718 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UQ26 | RIMS2 | S1108 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9UQ35 | SRRM2 | S2090 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y261 | FOXA2 | T156 | psp | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y283 | INVS | S1030 | ochoa | Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) | Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15852005, ECO:0000269|PubMed:18371931}. |
| Q9Y2H9 | MAST1 | S1426 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2T7 | YBX2 | S189 | ochoa | Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog) | Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250|UniProtKB:Q9Z2C8}. |
| Q9Y2X7 | GIT1 | S154 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y2X7 | GIT1 | S410 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y314 | NOSIP | S107 | ochoa | Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. |
| Q9Y320 | TMX2 | S243 | ochoa | Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14) | Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain. {ECO:0000269|PubMed:31735293}. |
| Q9Y478 | PRKAB1 | S25 | ochoa|psp | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Q9Y4B5 | MTCL1 | S1523 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4H2 | IRS2 | S1149 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6C9 | MTCH2 | S80 | ochoa | Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein) | Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity). {ECO:0000250|UniProtKB:Q791V5, ECO:0000269|PubMed:36264797}. |
| Q9Y6D5 | ARFGEF2 | S1024 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9Y6N7 | ROBO1 | S1442 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| P05787 | KRT8 | S404 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| Q9NXH9 | TRMT1 | S524 | Sugiyama | tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA methyltransferase 1) (hTRM1) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) | Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:10982862, PubMed:28784718, PubMed:37204604, PubMed:39786990). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (PubMed:28784718). {ECO:0000269|PubMed:10982862, ECO:0000269|PubMed:28784718, ECO:0000269|PubMed:37204604, ECO:0000269|PubMed:39786990}. |
| P21980 | TGM2 | S225 | Sugiyama | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P00519 | ABL1 | S642 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P28074 | PSMB5 | S229 | Sugiyama | Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| Q8N3Y1 | FBXW8 | S85 | SIGNOR | F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29) | Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17205132, PubMed:18498745, PubMed:21572988, PubMed:24362026, PubMed:35982156). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). The Cul7-RING(FBXW8) complex also mediates ubiquitination of phosphorylated cyclin-D1 (CCND1) (PubMed:17205132). The Cul7-RING(FBXW8) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000250|UniProtKB:Q8BIA4, ECO:0000269|PubMed:17205132, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:35982156}. |
| P49760 | CLK2 | S142 | GPS6|SIGNOR|EPSD|Sugiyama | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
| Q01082 | SPTBN1 | S446 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q00341 | HDLBP | S645 | Sugiyama | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q13131 | PRKAA1 | S415 | Sugiyama | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q9H078 | CLPB | S155 | Sugiyama | Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842). {ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:32573439, ECO:0000269|PubMed:34115842, ECO:0000269|PubMed:35247700, ECO:0000269|PubMed:36170828, ECO:0000269|PubMed:36745679}. |
| Q9UK23 | NAGPA | S145 | Sugiyama | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) | Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. {ECO:0000269|PubMed:23572527}. |
| P52789 | HK2 | S408 | Sugiyama | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-193648 | NRAGE signals death through JNK | 0.000089 | 4.049 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.000312 | 3.506 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.000370 | 3.432 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.000447 | 3.350 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.000595 | 3.225 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.001749 | 2.757 |
| R-HSA-73887 | Death Receptor Signaling | 0.001994 | 2.700 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.002974 | 2.527 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.002809 | 2.551 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.003348 | 2.475 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.004480 | 2.349 |
| R-HSA-74713 | IRS activation | 0.005775 | 2.238 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.004847 | 2.315 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.005775 | 2.238 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.007465 | 2.127 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.007723 | 2.112 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.008873 | 2.052 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.009381 | 2.028 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.009243 | 2.034 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.009350 | 2.029 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.010129 | 1.994 |
| R-HSA-112412 | SOS-mediated signalling | 0.011423 | 1.942 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.012730 | 1.895 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.012730 | 1.895 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.016110 | 1.793 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.016110 | 1.793 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.017696 | 1.752 |
| R-HSA-198203 | PI3K/AKT activation | 0.018712 | 1.728 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.018712 | 1.728 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.015411 | 1.812 |
| R-HSA-74749 | Signal attenuation | 0.018712 | 1.728 |
| R-HSA-525793 | Myogenesis | 0.015097 | 1.821 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.016109 | 1.793 |
| R-HSA-9613354 | Lipophagy | 0.016110 | 1.793 |
| R-HSA-448706 | Interleukin-1 processing | 0.016110 | 1.793 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.018243 | 1.739 |
| R-HSA-2586552 | Signaling by Leptin | 0.018712 | 1.728 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.020528 | 1.688 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.020897 | 1.680 |
| R-HSA-428540 | Activation of RAC1 | 0.024401 | 1.613 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.061851 | 1.209 |
| R-HSA-8941237 | Invadopodia formation | 0.076709 | 1.115 |
| R-HSA-5579024 | Defective MAT1A causes MATD | 0.091333 | 1.039 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 0.105726 | 0.976 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.119891 | 0.921 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.119891 | 0.921 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.119891 | 0.921 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.030700 | 1.513 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.133833 | 0.873 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.133833 | 0.873 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.147555 | 0.831 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.161061 | 0.793 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.174353 | 0.759 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.174353 | 0.759 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.187436 | 0.727 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.028633 | 1.543 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.212985 | 0.672 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.225458 | 0.647 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.044614 | 1.351 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.123883 | 0.907 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.261707 | 0.582 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.261707 | 0.582 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.261707 | 0.582 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.072325 | 1.141 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.075151 | 1.124 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.284929 | 0.545 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.307424 | 0.512 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.329213 | 0.483 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.339851 | 0.469 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.339851 | 0.469 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.159503 | 0.797 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.190839 | 0.719 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.190839 | 0.719 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.347989 | 0.458 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.317619 | 0.498 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.317619 | 0.498 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.254964 | 0.594 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.236286 | 0.627 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.261556 | 0.582 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.240327 | 0.619 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.044614 | 1.351 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.187436 | 0.727 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.200312 | 0.698 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.113440 | 0.945 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.069547 | 1.158 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.212985 | 0.672 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.284929 | 0.545 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.225458 | 0.647 |
| R-HSA-72172 | mRNA Splicing | 0.288212 | 0.540 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.299168 | 0.524 |
| R-HSA-72187 | mRNA 3'-end processing | 0.072325 | 1.141 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.284929 | 0.545 |
| R-HSA-3928664 | Ephrin signaling | 0.307424 | 0.512 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.040398 | 1.394 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.080948 | 1.092 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.119891 | 0.921 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.066819 | 1.175 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.187436 | 0.727 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.301498 | 0.521 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.244550 | 0.612 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.244550 | 0.612 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.156438 | 0.806 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.083918 | 1.076 |
| R-HSA-187024 | NGF-independant TRKA activation | 0.119891 | 0.921 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.133833 | 0.873 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.037566 | 1.425 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.147555 | 0.831 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.161061 | 0.793 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.161061 | 0.793 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.052833 | 1.277 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.212985 | 0.672 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.118632 | 0.926 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.072325 | 1.141 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.026674 | 1.574 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.284929 | 0.545 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.086933 | 1.061 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.099440 | 1.002 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.213499 | 0.671 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.350320 | 0.456 |
| R-HSA-8951664 | Neddylation | 0.093720 | 1.028 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.061157 | 1.214 |
| R-HSA-9907900 | Proteasome assembly | 0.051534 | 1.288 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.112624 | 0.948 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.273410 | 0.563 |
| R-HSA-112399 | IRS-mediated signalling | 0.278018 | 0.556 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.265832 | 0.575 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.213499 | 0.671 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.039498 | 1.403 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.237734 | 0.624 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.127201 | 0.896 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.319025 | 0.496 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.147555 | 0.831 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.174353 | 0.759 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.319025 | 0.496 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.108683 | 0.964 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.287326 | 0.542 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.167966 | 0.775 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.324846 | 0.488 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.083698 | 1.077 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.133552 | 0.874 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.133552 | 0.874 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.161061 | 0.793 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.174353 | 0.759 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.187436 | 0.727 |
| R-HSA-1483226 | Synthesis of PI | 0.200312 | 0.698 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.200312 | 0.698 |
| R-HSA-69541 | Stabilization of p53 | 0.038193 | 1.418 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.123883 | 0.907 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.037397 | 1.427 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.145405 | 0.837 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.145405 | 0.837 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.184643 | 0.734 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.219324 | 0.659 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.254491 | 0.594 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.260372 | 0.584 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.129965 | 0.886 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.137164 | 0.863 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.350320 | 0.456 |
| R-HSA-9842663 | Signaling by LTK | 0.225458 | 0.647 |
| R-HSA-9766229 | Degradation of CDH1 | 0.064142 | 1.193 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.140809 | 0.851 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.056809 | 1.246 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.133833 | 0.873 |
| R-HSA-8941413 | Events associated with phagocytolytic activity of PMN cells | 0.261707 | 0.582 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.156438 | 0.806 |
| R-HSA-4641258 | Degradation of DVL | 0.156438 | 0.806 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.184643 | 0.734 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.329213 | 0.483 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.129188 | 0.889 |
| R-HSA-5689603 | UCH proteinases | 0.151935 | 0.818 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.029616 | 1.528 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.061193 | 1.213 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.105726 | 0.976 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.119891 | 0.921 |
| R-HSA-187015 | Activation of TRKA receptors | 0.147555 | 0.831 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.161061 | 0.793 |
| R-HSA-176974 | Unwinding of DNA | 0.174353 | 0.759 |
| R-HSA-425381 | Bicarbonate transporters | 0.200312 | 0.698 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.273410 | 0.563 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.150901 | 0.821 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.150901 | 0.821 |
| R-HSA-4641257 | Degradation of AXIN | 0.156438 | 0.806 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.156438 | 0.806 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.318405 | 0.497 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.260372 | 0.584 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.140387 | 0.853 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.079699 | 1.099 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.058941 | 1.230 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.189222 | 0.723 |
| R-HSA-9663891 | Selective autophagy | 0.202970 | 0.693 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.064142 | 1.193 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.064142 | 1.193 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.129188 | 0.889 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.329213 | 0.483 |
| R-HSA-1632852 | Macroautophagy | 0.246550 | 0.608 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.102675 | 0.989 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.047339 | 1.325 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.088962 | 1.051 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.047339 | 1.325 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.040865 | 1.389 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.119891 | 0.921 |
| R-HSA-8964011 | HDL clearance | 0.133833 | 0.873 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.174353 | 0.759 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.261707 | 0.582 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.134545 | 0.871 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.134545 | 0.871 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.139952 | 0.854 |
| R-HSA-169911 | Regulation of Apoptosis | 0.145405 | 0.837 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.102675 | 0.989 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.184643 | 0.734 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.219324 | 0.659 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.304619 | 0.516 |
| R-HSA-69306 | DNA Replication | 0.292015 | 0.535 |
| R-HSA-422475 | Axon guidance | 0.039657 | 1.402 |
| R-HSA-8953854 | Metabolism of RNA | 0.058316 | 1.234 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.052833 | 1.277 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.105951 | 0.975 |
| R-HSA-9612973 | Autophagy | 0.302677 | 0.519 |
| R-HSA-9675108 | Nervous system development | 0.061645 | 1.210 |
| R-HSA-165159 | MTOR signalling | 0.046866 | 1.329 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.099440 | 1.002 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.044957 | 1.347 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 0.296266 | 0.528 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.173267 | 0.761 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.178941 | 0.747 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.178941 | 0.747 |
| R-HSA-109704 | PI3K Cascade | 0.236872 | 0.625 |
| R-HSA-202424 | Downstream TCR signaling | 0.211156 | 0.675 |
| R-HSA-418990 | Adherens junctions interactions | 0.331553 | 0.479 |
| R-HSA-5688426 | Deubiquitination | 0.153270 | 0.815 |
| R-HSA-446728 | Cell junction organization | 0.340909 | 0.467 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.261707 | 0.582 |
| R-HSA-9659379 | Sensory processing of sound | 0.163330 | 0.787 |
| R-HSA-69239 | Synthesis of DNA | 0.295964 | 0.529 |
| R-HSA-69206 | G1/S Transition | 0.186779 | 0.729 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.187436 | 0.727 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.167624 | 0.776 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.167624 | 0.776 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.173267 | 0.761 |
| R-HSA-5260271 | Diseases of Immune System | 0.173267 | 0.761 |
| R-HSA-8854214 | TBC/RABGAPs | 0.196123 | 0.707 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.196123 | 0.707 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.201896 | 0.695 |
| R-HSA-198753 | ERK/MAPK targets | 0.339851 | 0.469 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.207689 | 0.683 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.070214 | 1.154 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.342226 | 0.466 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.128624 | 0.891 |
| R-HSA-1500931 | Cell-Cell communication | 0.291452 | 0.535 |
| R-HSA-199991 | Membrane Trafficking | 0.118829 | 0.925 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.034960 | 1.456 |
| R-HSA-2028269 | Signaling by Hippo | 0.296266 | 0.528 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.145405 | 0.837 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.227735 | 0.643 |
| R-HSA-162582 | Signal Transduction | 0.218538 | 0.660 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.069171 | 1.160 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.248786 | 0.604 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.032284 | 1.491 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.103244 | 0.986 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.083918 | 1.076 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.207689 | 0.683 |
| R-HSA-9758941 | Gastrulation | 0.130948 | 0.883 |
| R-HSA-69481 | G2/M Checkpoints | 0.193178 | 0.714 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.246065 | 0.609 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.346445 | 0.460 |
| R-HSA-449836 | Other interleukin signaling | 0.318405 | 0.497 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.158907 | 0.799 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.139952 | 0.854 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.284929 | 0.545 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.173267 | 0.761 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.339851 | 0.469 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.330654 | 0.481 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.309810 | 0.509 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.035075 | 1.455 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.048837 | 1.311 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.350320 | 0.456 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.099440 | 1.002 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.187436 | 0.727 |
| R-HSA-210991 | Basigin interactions | 0.339851 | 0.469 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.144486 | 0.840 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.084513 | 1.073 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.124036 | 0.906 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.063601 | 1.197 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.138030 | 0.860 |
| R-HSA-68882 | Mitotic Anaphase | 0.325313 | 0.488 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.273410 | 0.563 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.207689 | 0.683 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.207689 | 0.683 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.328431 | 0.484 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.129974 | 0.886 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.213499 | 0.671 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.213499 | 0.671 |
| R-HSA-70171 | Glycolysis | 0.261556 | 0.582 |
| R-HSA-109581 | Apoptosis | 0.324124 | 0.489 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.127201 | 0.896 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.026505 | 1.577 |
| R-HSA-373753 | Nephrin family interactions | 0.329213 | 0.483 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.254491 | 0.594 |
| R-HSA-186712 | Regulation of beta-cell development | 0.289769 | 0.538 |
| R-HSA-202403 | TCR signaling | 0.308950 | 0.510 |
| R-HSA-166520 | Signaling by NTRKs | 0.128624 | 0.891 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.098543 | 1.006 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.043386 | 1.363 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.098543 | 1.006 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.098543 | 1.006 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.108584 | 0.964 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.196403 | 0.707 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.242739 | 0.615 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.129965 | 0.886 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.155244 | 0.809 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.164962 | 0.783 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.164962 | 0.783 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.174197 | 0.759 |
| R-HSA-9909396 | Circadian clock | 0.212770 | 0.672 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.043386 | 1.363 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.174197 | 0.759 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.129974 | 0.886 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.141263 | 0.850 |
| R-HSA-351202 | Metabolism of polyamines | 0.295637 | 0.529 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.334965 | 0.475 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.149984 | 0.824 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.056941 | 1.245 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.312873 | 0.505 |
| R-HSA-9824272 | Somitogenesis | 0.207689 | 0.683 |
| R-HSA-70326 | Glucose metabolism | 0.347963 | 0.458 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.237734 | 0.624 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.062014 | 1.208 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.296266 | 0.528 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.178941 | 0.747 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.088470 | 1.053 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.249816 | 0.602 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.194862 | 0.710 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.079009 | 1.102 |
| R-HSA-622312 | Inflammasomes | 0.103244 | 0.986 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.318405 | 0.497 |
| R-HSA-449147 | Signaling by Interleukins | 0.337290 | 0.472 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.324846 | 0.488 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.240398 | 0.619 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.319025 | 0.496 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.352158 | 0.453 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.353736 | 0.451 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.356614 | 0.448 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.357584 | 0.447 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.360624 | 0.443 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.360624 | 0.443 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.360624 | 0.443 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.360624 | 0.443 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.365174 | 0.438 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.365254 | 0.437 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.365254 | 0.437 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.367249 | 0.435 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.367249 | 0.435 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.367249 | 0.435 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.370864 | 0.431 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.371911 | 0.430 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.374437 | 0.427 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.376535 | 0.424 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.378175 | 0.422 |
| R-HSA-9865881 | Complex III assembly | 0.380746 | 0.419 |
| R-HSA-429947 | Deadenylation of mRNA | 0.380746 | 0.419 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.380746 | 0.419 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.380746 | 0.419 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.382184 | 0.418 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.387811 | 0.411 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.390569 | 0.408 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.390569 | 0.408 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.390569 | 0.408 |
| R-HSA-3214842 | HDMs demethylate histones | 0.390569 | 0.408 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.391704 | 0.407 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.398997 | 0.399 |
| R-HSA-5619084 | ABC transporter disorders | 0.398997 | 0.399 |
| R-HSA-4086400 | PCP/CE pathway | 0.398997 | 0.399 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.400237 | 0.398 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.400237 | 0.398 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.404555 | 0.393 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.409752 | 0.387 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.409752 | 0.387 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.409752 | 0.387 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.409752 | 0.387 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.409752 | 0.387 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.409752 | 0.387 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.409752 | 0.387 |
| R-HSA-264876 | Insulin processing | 0.409752 | 0.387 |
| R-HSA-69275 | G2/M Transition | 0.413797 | 0.383 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.419117 | 0.378 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.419117 | 0.378 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.419117 | 0.378 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.420783 | 0.376 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.420905 | 0.376 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.428333 | 0.368 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.428333 | 0.368 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.428333 | 0.368 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.428333 | 0.368 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.428333 | 0.368 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.428333 | 0.368 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.431962 | 0.365 |
| R-HSA-421270 | Cell-cell junction organization | 0.434938 | 0.362 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.437364 | 0.359 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.437405 | 0.359 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.437405 | 0.359 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.442737 | 0.354 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.446332 | 0.350 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.448083 | 0.349 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.449114 | 0.348 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.453399 | 0.344 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.455119 | 0.342 |
| R-HSA-69190 | DNA strand elongation | 0.455119 | 0.342 |
| R-HSA-156902 | Peptide chain elongation | 0.458686 | 0.338 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.458686 | 0.338 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.463766 | 0.334 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.463766 | 0.334 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.463766 | 0.334 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.463766 | 0.334 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.463766 | 0.334 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.463766 | 0.334 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.463766 | 0.334 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.463944 | 0.334 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.472277 | 0.326 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.472277 | 0.326 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.473439 | 0.325 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.474369 | 0.324 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.478665 | 0.320 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.479535 | 0.319 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.480654 | 0.318 |
| R-HSA-5205647 | Mitophagy | 0.480654 | 0.318 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.480654 | 0.318 |
| R-HSA-1266738 | Developmental Biology | 0.483477 | 0.316 |
| R-HSA-5357801 | Programmed Cell Death | 0.483743 | 0.315 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.484670 | 0.315 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.484670 | 0.315 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.484670 | 0.315 |
| R-HSA-391251 | Protein folding | 0.484670 | 0.315 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.488898 | 0.311 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.490725 | 0.309 |
| R-HSA-69242 | S Phase | 0.494715 | 0.306 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.497011 | 0.304 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.497011 | 0.304 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.497011 | 0.304 |
| R-HSA-8853659 | RET signaling | 0.497011 | 0.304 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.499887 | 0.301 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.504895 | 0.297 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.504895 | 0.297 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.504997 | 0.297 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.504997 | 0.297 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.506591 | 0.295 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.512856 | 0.290 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.512856 | 0.290 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.512856 | 0.290 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.514813 | 0.288 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.520590 | 0.284 |
| R-HSA-201556 | Signaling by ALK | 0.520590 | 0.284 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.520590 | 0.284 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.528203 | 0.277 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.528203 | 0.277 |
| R-HSA-167169 | HIV Transcription Elongation | 0.528203 | 0.277 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.528203 | 0.277 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.529444 | 0.276 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.532749 | 0.273 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.534254 | 0.272 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.535694 | 0.271 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.535694 | 0.271 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.535694 | 0.271 |
| R-HSA-9694548 | Maturation of spike protein | 0.535694 | 0.271 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.535694 | 0.271 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.535694 | 0.271 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.539030 | 0.268 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.541325 | 0.267 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.543068 | 0.265 |
| R-HSA-192823 | Viral mRNA Translation | 0.543773 | 0.265 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.548481 | 0.261 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.548481 | 0.261 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.556306 | 0.255 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.562403 | 0.250 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.564496 | 0.248 |
| R-HSA-156581 | Methylation | 0.564496 | 0.248 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.564496 | 0.248 |
| R-HSA-69236 | G1 Phase | 0.564496 | 0.248 |
| R-HSA-373752 | Netrin-1 signaling | 0.564496 | 0.248 |
| R-HSA-73894 | DNA Repair | 0.566680 | 0.247 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.566975 | 0.246 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.571413 | 0.243 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.571413 | 0.243 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.571413 | 0.243 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.571413 | 0.243 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.571513 | 0.243 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.571513 | 0.243 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.571513 | 0.243 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.578222 | 0.238 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.578222 | 0.238 |
| R-HSA-75153 | Apoptotic execution phase | 0.578222 | 0.238 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.584922 | 0.233 |
| R-HSA-418555 | G alpha (s) signalling events | 0.585378 | 0.233 |
| R-HSA-9634597 | GPER1 signaling | 0.591517 | 0.228 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.595003 | 0.225 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.598007 | 0.223 |
| R-HSA-73893 | DNA Damage Bypass | 0.598007 | 0.223 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.598013 | 0.223 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.598013 | 0.223 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.599453 | 0.222 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.614989 | 0.211 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.614989 | 0.211 |
| R-HSA-2559583 | Cellular Senescence | 0.616603 | 0.210 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.616867 | 0.210 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.616867 | 0.210 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.616867 | 0.210 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.619146 | 0.208 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.622956 | 0.206 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.622956 | 0.206 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.622956 | 0.206 |
| R-HSA-5693538 | Homology Directed Repair | 0.623269 | 0.205 |
| R-HSA-4839726 | Chromatin organization | 0.623581 | 0.205 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.626027 | 0.203 |
| R-HSA-72649 | Translation initiation complex formation | 0.628949 | 0.201 |
| R-HSA-418597 | G alpha (z) signalling events | 0.634846 | 0.197 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.634846 | 0.197 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.640650 | 0.193 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.640650 | 0.193 |
| R-HSA-75893 | TNF signaling | 0.640650 | 0.193 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.640650 | 0.193 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.640940 | 0.193 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.643002 | 0.192 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.646363 | 0.190 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.647285 | 0.189 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.651985 | 0.186 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.651985 | 0.186 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.651985 | 0.186 |
| R-HSA-191859 | snRNP Assembly | 0.657517 | 0.182 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.657517 | 0.182 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.657517 | 0.182 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.657517 | 0.182 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.657517 | 0.182 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.657517 | 0.182 |
| R-HSA-68877 | Mitotic Prometaphase | 0.658841 | 0.181 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.662963 | 0.179 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.662963 | 0.179 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.662963 | 0.179 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.662963 | 0.179 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.662963 | 0.179 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.662963 | 0.179 |
| R-HSA-983189 | Kinesins | 0.662963 | 0.179 |
| R-HSA-450294 | MAP kinase activation | 0.668322 | 0.175 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.673596 | 0.172 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.673596 | 0.172 |
| R-HSA-1474165 | Reproduction | 0.677406 | 0.169 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.678786 | 0.168 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.678786 | 0.168 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.678786 | 0.168 |
| R-HSA-373755 | Semaphorin interactions | 0.678786 | 0.168 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.678786 | 0.168 |
| R-HSA-8848021 | Signaling by PTK6 | 0.678786 | 0.168 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.686066 | 0.164 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.693870 | 0.159 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.693870 | 0.159 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.698739 | 0.156 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.698739 | 0.156 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.698739 | 0.156 |
| R-HSA-6805567 | Keratinization | 0.700478 | 0.155 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.702020 | 0.154 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.703531 | 0.153 |
| R-HSA-167172 | Transcription of the HIV genome | 0.703531 | 0.153 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.703531 | 0.153 |
| R-HSA-5218859 | Regulated Necrosis | 0.703531 | 0.153 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.708937 | 0.149 |
| R-HSA-9658195 | Leishmania infection | 0.708937 | 0.149 |
| R-HSA-6807070 | PTEN Regulation | 0.712083 | 0.147 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.712889 | 0.147 |
| R-HSA-448424 | Interleukin-17 signaling | 0.712889 | 0.147 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.717457 | 0.144 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.717457 | 0.144 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.721952 | 0.141 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.721952 | 0.141 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.721952 | 0.141 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.726377 | 0.139 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.728224 | 0.138 |
| R-HSA-1640170 | Cell Cycle | 0.730061 | 0.137 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.730731 | 0.136 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.730731 | 0.136 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.730731 | 0.136 |
| R-HSA-380287 | Centrosome maturation | 0.735016 | 0.134 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.739233 | 0.131 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.743384 | 0.129 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.747468 | 0.126 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.751488 | 0.124 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.755352 | 0.122 |
| R-HSA-162906 | HIV Infection | 0.755544 | 0.122 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.758217 | 0.120 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.763169 | 0.117 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.763862 | 0.117 |
| R-HSA-72312 | rRNA processing | 0.767390 | 0.115 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.770650 | 0.113 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.771996 | 0.112 |
| R-HSA-9711097 | Cellular response to starvation | 0.772116 | 0.112 |
| R-HSA-68886 | M Phase | 0.772131 | 0.112 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.774303 | 0.111 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.777478 | 0.109 |
| R-HSA-8939211 | ESR-mediated signaling | 0.778766 | 0.109 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.784915 | 0.105 |
| R-HSA-157118 | Signaling by NOTCH | 0.785370 | 0.105 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.788341 | 0.103 |
| R-HSA-112316 | Neuronal System | 0.794421 | 0.100 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.795030 | 0.100 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.795030 | 0.100 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.798296 | 0.098 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.804672 | 0.094 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.804672 | 0.094 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.805042 | 0.094 |
| R-HSA-72306 | tRNA processing | 0.805042 | 0.094 |
| R-HSA-1474290 | Collagen formation | 0.810847 | 0.091 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.813861 | 0.089 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.819747 | 0.086 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.819747 | 0.086 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.819747 | 0.086 |
| R-HSA-1296071 | Potassium Channels | 0.819747 | 0.086 |
| R-HSA-168255 | Influenza Infection | 0.825300 | 0.083 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.825447 | 0.083 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.825447 | 0.083 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.828230 | 0.082 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.833683 | 0.079 |
| R-HSA-1483255 | PI Metabolism | 0.836315 | 0.078 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.838925 | 0.076 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.839467 | 0.076 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.841493 | 0.075 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.841771 | 0.075 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.844021 | 0.074 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.844021 | 0.074 |
| R-HSA-72766 | Translation | 0.846746 | 0.072 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.856069 | 0.067 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.858365 | 0.066 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.861706 | 0.065 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.862848 | 0.064 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.865037 | 0.063 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.869310 | 0.061 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.873448 | 0.059 |
| R-HSA-373760 | L1CAM interactions | 0.875468 | 0.058 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.877455 | 0.057 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.882081 | 0.054 |
| R-HSA-195721 | Signaling by WNT | 0.883995 | 0.054 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.887271 | 0.052 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.888735 | 0.051 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.889233 | 0.051 |
| R-HSA-388396 | GPCR downstream signalling | 0.891126 | 0.050 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.893981 | 0.049 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.893981 | 0.049 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.893981 | 0.049 |
| R-HSA-194138 | Signaling by VEGF | 0.893981 | 0.049 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.895572 | 0.048 |
| R-HSA-114608 | Platelet degranulation | 0.897340 | 0.047 |
| R-HSA-597592 | Post-translational protein modification | 0.904805 | 0.043 |
| R-HSA-9843745 | Adipogenesis | 0.905283 | 0.043 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.906796 | 0.042 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.907023 | 0.042 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.908285 | 0.042 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.909311 | 0.041 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.914009 | 0.039 |
| R-HSA-5173105 | O-linked glycosylation | 0.915384 | 0.038 |
| R-HSA-5368287 | Mitochondrial translation | 0.916737 | 0.038 |
| R-HSA-9664407 | Parasite infection | 0.919377 | 0.037 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.919377 | 0.037 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.919377 | 0.037 |
| R-HSA-1474244 | Extracellular matrix organization | 0.919999 | 0.036 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.920666 | 0.036 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.922022 | 0.035 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.923183 | 0.035 |
| R-HSA-1280218 | Adaptive Immune System | 0.923463 | 0.035 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.927419 | 0.033 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.932480 | 0.030 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.936698 | 0.028 |
| R-HSA-9610379 | HCMV Late Events | 0.939689 | 0.027 |
| R-HSA-162587 | HIV Life Cycle | 0.939689 | 0.027 |
| R-HSA-372790 | Signaling by GPCR | 0.943304 | 0.025 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.943587 | 0.025 |
| R-HSA-6798695 | Neutrophil degranulation | 0.948143 | 0.023 |
| R-HSA-212436 | Generic Transcription Pathway | 0.950597 | 0.022 |
| R-HSA-9679506 | SARS-CoV Infections | 0.954011 | 0.020 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.954164 | 0.020 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.954164 | 0.020 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.954899 | 0.020 |
| R-HSA-611105 | Respiratory electron transport | 0.957721 | 0.019 |
| R-HSA-3781865 | Diseases of glycosylation | 0.961628 | 0.017 |
| R-HSA-1483257 | Phospholipid metabolism | 0.961778 | 0.017 |
| R-HSA-5617833 | Cilium Assembly | 0.965175 | 0.015 |
| R-HSA-9609690 | HCMV Early Events | 0.968396 | 0.014 |
| R-HSA-168249 | Innate Immune System | 0.971271 | 0.013 |
| R-HSA-2262752 | Cellular responses to stress | 0.971605 | 0.013 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.971780 | 0.012 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.973365 | 0.012 |
| R-HSA-397014 | Muscle contraction | 0.975997 | 0.011 |
| R-HSA-74160 | Gene expression (Transcription) | 0.978532 | 0.009 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.981078 | 0.008 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.982383 | 0.008 |
| R-HSA-15869 | Metabolism of nucleotides | 0.983731 | 0.007 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.983993 | 0.007 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.984504 | 0.007 |
| R-HSA-392499 | Metabolism of proteins | 0.987033 | 0.006 |
| R-HSA-9609646 | HCMV Infection | 0.987037 | 0.006 |
| R-HSA-9824446 | Viral Infection Pathways | 0.989359 | 0.005 |
| R-HSA-109582 | Hemostasis | 0.989616 | 0.005 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.990895 | 0.004 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.991222 | 0.004 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.991775 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 0.994075 | 0.003 |
| R-HSA-1643685 | Disease | 0.994842 | 0.002 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.996047 | 0.002 |
| R-HSA-8957322 | Metabolism of steroids | 0.996111 | 0.002 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.997053 | 0.001 |
| R-HSA-168256 | Immune System | 0.998496 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.998542 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.998699 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.998815 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.999015 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 0.999015 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999701 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999951 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
SRPK2 |
0.858 | 0.766 | -3 | 0.769 |
SRPK1 |
0.854 | 0.727 | -3 | 0.691 |
RSK2 |
0.846 | 0.742 | -3 | 0.651 |
MAPKAPK2 |
0.843 | 0.709 | -3 | 0.649 |
P90RSK |
0.842 | 0.775 | -3 | 0.651 |
SRPK3 |
0.839 | 0.693 | -3 | 0.695 |
RSK3 |
0.839 | 0.733 | -3 | 0.648 |
PRKD2 |
0.838 | 0.673 | -3 | 0.591 |
AKT2 |
0.837 | 0.753 | -3 | 0.738 |
CDKL5 |
0.837 | 0.707 | -3 | 0.620 |
RSK4 |
0.836 | 0.698 | -3 | 0.681 |
SBK |
0.835 | 0.833 | -3 | 0.826 |
CDKL1 |
0.835 | 0.817 | -3 | 0.597 |
PIM1 |
0.835 | 0.725 | -3 | 0.612 |
CLK1 |
0.834 | 0.645 | -3 | 0.647 |
CLK2 |
0.833 | 0.617 | -3 | 0.679 |
MAPKAPK3 |
0.833 | 0.703 | -3 | 0.558 |
HIPK4 |
0.832 | 0.560 | 1 | 0.831 |
SGK1 |
0.832 | 0.777 | -3 | 0.807 |
AKT3 |
0.831 | 0.730 | -3 | 0.796 |
PIM3 |
0.830 | 0.656 | -3 | 0.516 |
PRKX |
0.830 | 0.582 | -3 | 0.679 |
PRKD3 |
0.830 | 0.724 | -3 | 0.643 |
CLK4 |
0.829 | 0.628 | -3 | 0.641 |
MSK2 |
0.827 | 0.691 | -3 | 0.667 |
PRKD1 |
0.827 | 0.567 | -3 | 0.487 |
PKACB |
0.827 | 0.538 | -2 | 0.612 |
MSK1 |
0.826 | 0.623 | -3 | 0.651 |
PIM2 |
0.825 | 0.724 | -3 | 0.663 |
PKACA |
0.823 | 0.562 | -2 | 0.562 |
P70S6KB |
0.823 | 0.656 | -3 | 0.576 |
NDR2 |
0.823 | 0.469 | -3 | 0.437 |
AKT1 |
0.823 | 0.669 | -3 | 0.696 |
DYRK1A |
0.821 | 0.604 | 1 | 0.782 |
CHK2 |
0.821 | 0.796 | -3 | 0.759 |
ICK |
0.819 | 0.652 | -3 | 0.529 |
P70S6K |
0.819 | 0.700 | -3 | 0.684 |
MAPKAPK5 |
0.819 | 0.722 | -3 | 0.641 |
CLK3 |
0.819 | 0.385 | 1 | 0.838 |
SIK |
0.819 | 0.614 | -3 | 0.570 |
NDR1 |
0.818 | 0.533 | -3 | 0.472 |
SGK3 |
0.818 | 0.633 | -3 | 0.590 |
CAMK1D |
0.817 | 0.726 | -3 | 0.685 |
NUAK2 |
0.817 | 0.594 | -3 | 0.495 |
HIPK2 |
0.817 | 0.439 | 1 | 0.676 |
HIPK1 |
0.816 | 0.518 | 1 | 0.776 |
MAK |
0.815 | 0.591 | -2 | 0.753 |
DYRK3 |
0.815 | 0.564 | 1 | 0.787 |
PKACG |
0.815 | 0.473 | -2 | 0.680 |
LATS2 |
0.815 | 0.405 | -5 | 0.810 |
DYRK2 |
0.815 | 0.418 | 1 | 0.756 |
AMPKA2 |
0.813 | 0.559 | -3 | 0.492 |
CAMK2D |
0.812 | 0.478 | -3 | 0.414 |
PKN3 |
0.812 | 0.545 | -3 | 0.486 |
CAMK1A |
0.812 | 0.718 | -3 | 0.727 |
NUAK1 |
0.811 | 0.568 | -3 | 0.552 |
CAMK1B |
0.811 | 0.654 | -3 | 0.446 |
CAMK2A |
0.810 | 0.497 | 2 | 0.801 |
MOK |
0.810 | 0.638 | 1 | 0.772 |
AMPKA1 |
0.808 | 0.498 | -3 | 0.427 |
MELK |
0.808 | 0.578 | -3 | 0.507 |
QSK |
0.807 | 0.461 | 4 | 0.809 |
HIPK3 |
0.807 | 0.503 | 1 | 0.778 |
AURC |
0.807 | 0.290 | -2 | 0.596 |
BRSK1 |
0.807 | 0.533 | -3 | 0.547 |
CAMK1G |
0.806 | 0.636 | -3 | 0.619 |
SKMLCK |
0.805 | 0.435 | -2 | 0.816 |
MYLK4 |
0.805 | 0.515 | -2 | 0.722 |
PKG2 |
0.805 | 0.409 | -2 | 0.612 |
CAMK2B |
0.804 | 0.422 | 2 | 0.803 |
DCAMKL1 |
0.804 | 0.622 | -3 | 0.548 |
TSSK1 |
0.804 | 0.427 | -3 | 0.407 |
DYRK1B |
0.801 | 0.407 | 1 | 0.708 |
PKN2 |
0.801 | 0.437 | -3 | 0.427 |
CAMLCK |
0.801 | 0.502 | -2 | 0.801 |
PKN1 |
0.800 | 0.615 | -3 | 0.654 |
DAPK2 |
0.800 | 0.582 | -3 | 0.410 |
MARK4 |
0.799 | 0.282 | 4 | 0.833 |
PKCD |
0.799 | 0.391 | 2 | 0.737 |
DYRK4 |
0.799 | 0.352 | 1 | 0.681 |
COT |
0.799 | 0.055 | 2 | 0.843 |
CRIK |
0.799 | 0.702 | -3 | 0.713 |
CDC7 |
0.798 | 0.131 | 1 | 0.830 |
MRCKB |
0.797 | 0.606 | -3 | 0.627 |
CAMK4 |
0.797 | 0.444 | -3 | 0.451 |
WNK1 |
0.797 | 0.298 | -2 | 0.838 |
BRSK2 |
0.797 | 0.409 | -3 | 0.458 |
PHKG1 |
0.796 | 0.430 | -3 | 0.467 |
AURB |
0.796 | 0.283 | -2 | 0.592 |
PAK1 |
0.795 | 0.335 | -2 | 0.744 |
NLK |
0.795 | 0.200 | 1 | 0.867 |
LATS1 |
0.794 | 0.411 | -3 | 0.404 |
QIK |
0.794 | 0.398 | -3 | 0.399 |
PAK3 |
0.792 | 0.313 | -2 | 0.747 |
MRCKA |
0.792 | 0.576 | -3 | 0.596 |
NIK |
0.792 | 0.477 | -3 | 0.329 |
NIM1 |
0.791 | 0.327 | 3 | 0.767 |
PAK6 |
0.791 | 0.231 | -2 | 0.669 |
PKCB |
0.791 | 0.351 | 2 | 0.681 |
CHK1 |
0.791 | 0.400 | -3 | 0.397 |
MST4 |
0.790 | 0.197 | 2 | 0.835 |
MNK2 |
0.790 | 0.257 | -2 | 0.737 |
MARK3 |
0.789 | 0.298 | 4 | 0.773 |
SMMLCK |
0.789 | 0.564 | -3 | 0.522 |
IKKB |
0.789 | 0.080 | -2 | 0.725 |
TSSK2 |
0.789 | 0.322 | -5 | 0.902 |
DMPK1 |
0.788 | 0.598 | -3 | 0.607 |
RAF1 |
0.788 | 0.157 | 1 | 0.861 |
MOS |
0.788 | 0.088 | 1 | 0.864 |
PKG1 |
0.788 | 0.475 | -2 | 0.523 |
MNK1 |
0.787 | 0.282 | -2 | 0.746 |
ROCK2 |
0.787 | 0.573 | -3 | 0.550 |
MTOR |
0.787 | 0.027 | 1 | 0.807 |
PKCG |
0.787 | 0.310 | 2 | 0.672 |
DAPK3 |
0.786 | 0.566 | -3 | 0.564 |
PKCA |
0.786 | 0.282 | 2 | 0.668 |
MARK2 |
0.786 | 0.287 | 4 | 0.747 |
PRPK |
0.785 | -0.014 | -1 | 0.854 |
ATR |
0.785 | 0.095 | 1 | 0.829 |
MARK1 |
0.785 | 0.324 | 4 | 0.781 |
DCAMKL2 |
0.784 | 0.460 | -3 | 0.515 |
DAPK1 |
0.784 | 0.561 | -3 | 0.599 |
PDHK4 |
0.784 | -0.062 | 1 | 0.869 |
PHKG2 |
0.784 | 0.415 | -3 | 0.487 |
TBK1 |
0.783 | -0.002 | 1 | 0.783 |
PKCE |
0.782 | 0.430 | 2 | 0.656 |
PKCH |
0.782 | 0.337 | 2 | 0.658 |
PAK2 |
0.782 | 0.294 | -2 | 0.726 |
PKCT |
0.782 | 0.402 | 2 | 0.673 |
PAK5 |
0.781 | 0.279 | -2 | 0.607 |
AURA |
0.781 | 0.239 | -2 | 0.562 |
TGFBR2 |
0.781 | 0.082 | -2 | 0.727 |
RIPK3 |
0.781 | 0.066 | 3 | 0.740 |
CDK7 |
0.781 | 0.121 | 1 | 0.720 |
RIPK1 |
0.780 | 0.206 | 1 | 0.838 |
CAMK2G |
0.780 | 0.007 | 2 | 0.804 |
IKKE |
0.780 | -0.022 | 1 | 0.782 |
ROCK1 |
0.780 | 0.570 | -3 | 0.597 |
PDHK1 |
0.779 | -0.055 | 1 | 0.873 |
ERK5 |
0.779 | 0.036 | 1 | 0.794 |
CDK10 |
0.779 | 0.243 | 1 | 0.686 |
WNK3 |
0.778 | 0.125 | 1 | 0.835 |
PKCZ |
0.777 | 0.251 | 2 | 0.720 |
PAK4 |
0.777 | 0.260 | -2 | 0.607 |
GCN2 |
0.776 | -0.106 | 2 | 0.754 |
KIS |
0.776 | 0.027 | 1 | 0.744 |
ULK2 |
0.776 | -0.100 | 2 | 0.739 |
BMPR2 |
0.775 | -0.126 | -2 | 0.832 |
BCKDK |
0.775 | -0.024 | -1 | 0.803 |
CDK8 |
0.775 | 0.042 | 1 | 0.719 |
DSTYK |
0.775 | -0.111 | 2 | 0.851 |
CDK19 |
0.774 | 0.055 | 1 | 0.685 |
HUNK |
0.774 | 0.021 | 2 | 0.751 |
GRK1 |
0.774 | 0.014 | -2 | 0.762 |
MASTL |
0.774 | 0.053 | -2 | 0.780 |
PKCI |
0.773 | 0.310 | 2 | 0.687 |
SNRK |
0.773 | 0.309 | 2 | 0.610 |
CHAK2 |
0.772 | 0.009 | -1 | 0.849 |
SSTK |
0.772 | 0.258 | 4 | 0.792 |
PASK |
0.772 | 0.447 | -3 | 0.448 |
JNK2 |
0.772 | 0.097 | 1 | 0.672 |
CDK14 |
0.770 | 0.188 | 1 | 0.700 |
GRK6 |
0.769 | 0.019 | 1 | 0.828 |
GRK5 |
0.769 | -0.090 | -3 | 0.164 |
ATM |
0.769 | 0.046 | 1 | 0.768 |
WNK4 |
0.769 | 0.268 | -2 | 0.832 |
CDK18 |
0.769 | 0.087 | 1 | 0.650 |
IKKA |
0.769 | -0.056 | -2 | 0.723 |
FAM20C |
0.768 | 0.070 | 2 | 0.691 |
IRE1 |
0.768 | 0.077 | 1 | 0.810 |
DLK |
0.768 | 0.118 | 1 | 0.839 |
NEK9 |
0.768 | -0.076 | 2 | 0.788 |
PKR |
0.767 | 0.129 | 1 | 0.862 |
NEK7 |
0.767 | -0.140 | -3 | 0.140 |
MLK1 |
0.766 | -0.078 | 2 | 0.761 |
CK1E |
0.766 | -0.057 | -3 | 0.091 |
DNAPK |
0.766 | 0.055 | 1 | 0.729 |
CDK9 |
0.765 | 0.086 | 1 | 0.705 |
JNK3 |
0.765 | 0.065 | 1 | 0.698 |
P38A |
0.765 | 0.081 | 1 | 0.736 |
NEK6 |
0.765 | -0.124 | -2 | 0.796 |
CDK13 |
0.764 | 0.051 | 1 | 0.696 |
ANKRD3 |
0.764 | 0.019 | 1 | 0.879 |
CDK12 |
0.764 | 0.088 | 1 | 0.672 |
MLK2 |
0.764 | -0.062 | 2 | 0.778 |
ULK1 |
0.763 | -0.156 | -3 | 0.118 |
CK1G1 |
0.761 | -0.066 | -3 | 0.087 |
CDK5 |
0.761 | 0.059 | 1 | 0.730 |
TTBK2 |
0.761 | -0.063 | 2 | 0.642 |
NEK2 |
0.760 | -0.047 | 2 | 0.756 |
MPSK1 |
0.760 | 0.098 | 1 | 0.808 |
CK1A2 |
0.760 | -0.057 | -3 | 0.095 |
VRK2 |
0.760 | 0.015 | 1 | 0.895 |
MEK1 |
0.759 | 0.012 | 2 | 0.809 |
CK1D |
0.759 | -0.068 | -3 | 0.070 |
IRE2 |
0.758 | 0.031 | 2 | 0.692 |
PDK1 |
0.758 | 0.369 | 1 | 0.818 |
P38B |
0.758 | 0.059 | 1 | 0.665 |
SMG1 |
0.758 | -0.036 | 1 | 0.783 |
ALK4 |
0.758 | -0.032 | -2 | 0.780 |
GRK4 |
0.757 | -0.124 | -2 | 0.771 |
BMPR1B |
0.757 | -0.006 | 1 | 0.768 |
ERK1 |
0.756 | 0.049 | 1 | 0.664 |
CDK17 |
0.756 | 0.056 | 1 | 0.595 |
GRK7 |
0.756 | 0.031 | 1 | 0.743 |
TGFBR1 |
0.755 | -0.037 | -2 | 0.755 |
P38G |
0.755 | 0.059 | 1 | 0.592 |
CHAK1 |
0.755 | 0.005 | 2 | 0.720 |
PRP4 |
0.755 | -0.029 | -3 | 0.123 |
DRAK1 |
0.755 | 0.125 | 1 | 0.738 |
MLK3 |
0.755 | -0.051 | 2 | 0.686 |
IRAK4 |
0.755 | 0.090 | 1 | 0.828 |
YSK4 |
0.754 | -0.064 | 1 | 0.797 |
CDK1 |
0.754 | 0.034 | 1 | 0.669 |
MST3 |
0.753 | 0.099 | 2 | 0.784 |
ERK2 |
0.752 | 0.037 | 1 | 0.707 |
PLK1 |
0.752 | -0.069 | -2 | 0.735 |
BRAF |
0.752 | 0.049 | -4 | 0.770 |
BUB1 |
0.751 | 0.186 | -5 | 0.850 |
ALK2 |
0.750 | -0.032 | -2 | 0.761 |
CDK4 |
0.749 | 0.137 | 1 | 0.660 |
MEK5 |
0.749 | 0.030 | 2 | 0.783 |
TLK2 |
0.748 | -0.078 | 1 | 0.805 |
PERK |
0.748 | -0.060 | -2 | 0.774 |
MLK4 |
0.748 | -0.086 | 2 | 0.666 |
CDK16 |
0.748 | 0.056 | 1 | 0.613 |
PBK |
0.747 | 0.165 | 1 | 0.783 |
MEKK1 |
0.747 | -0.065 | 1 | 0.850 |
PINK1 |
0.747 | -0.092 | 1 | 0.847 |
TAO3 |
0.746 | 0.075 | 1 | 0.813 |
GSK3B |
0.746 | 0.036 | 4 | 0.483 |
HRI |
0.746 | -0.079 | -2 | 0.792 |
PLK3 |
0.746 | -0.101 | 2 | 0.741 |
P38D |
0.746 | 0.042 | 1 | 0.622 |
ACVR2A |
0.745 | -0.069 | -2 | 0.723 |
CDK3 |
0.745 | 0.042 | 1 | 0.613 |
ACVR2B |
0.745 | -0.081 | -2 | 0.740 |
IRAK1 |
0.745 | -0.000 | -1 | 0.761 |
NEK5 |
0.744 | -0.065 | 1 | 0.841 |
GRK2 |
0.744 | -0.051 | -2 | 0.667 |
GSK3A |
0.744 | 0.039 | 4 | 0.490 |
PLK4 |
0.744 | -0.044 | 2 | 0.574 |
GAK |
0.743 | 0.084 | 1 | 0.854 |
LKB1 |
0.743 | -0.013 | -3 | 0.153 |
TLK1 |
0.743 | -0.062 | -2 | 0.773 |
HPK1 |
0.743 | 0.151 | 1 | 0.816 |
MEKK2 |
0.742 | -0.039 | 2 | 0.760 |
CDK2 |
0.742 | -0.016 | 1 | 0.741 |
ZAK |
0.742 | -0.059 | 1 | 0.816 |
LOK |
0.741 | 0.132 | -2 | 0.730 |
CAMKK2 |
0.741 | -0.022 | -2 | 0.748 |
MEKK3 |
0.741 | -0.073 | 1 | 0.823 |
TAO2 |
0.740 | 0.061 | 2 | 0.798 |
HASPIN |
0.740 | 0.170 | -1 | 0.766 |
GCK |
0.740 | 0.083 | 1 | 0.821 |
MEKK6 |
0.740 | 0.095 | 1 | 0.806 |
LRRK2 |
0.739 | 0.176 | 2 | 0.788 |
KHS1 |
0.739 | 0.142 | 1 | 0.820 |
JNK1 |
0.739 | 0.037 | 1 | 0.649 |
HGK |
0.738 | 0.043 | 3 | 0.826 |
BMPR1A |
0.738 | -0.036 | 1 | 0.755 |
TNIK |
0.738 | 0.074 | 3 | 0.824 |
KHS2 |
0.738 | 0.159 | 1 | 0.827 |
NEK4 |
0.737 | -0.019 | 1 | 0.829 |
TTBK1 |
0.737 | -0.085 | 2 | 0.561 |
CDK6 |
0.736 | 0.057 | 1 | 0.684 |
NEK11 |
0.736 | -0.035 | 1 | 0.819 |
CAMKK1 |
0.735 | -0.112 | -2 | 0.755 |
GRK3 |
0.735 | -0.052 | -2 | 0.622 |
NEK8 |
0.735 | 0.027 | 2 | 0.754 |
MAP3K15 |
0.734 | 0.036 | 1 | 0.795 |
MINK |
0.734 | 0.026 | 1 | 0.827 |
NEK1 |
0.734 | -0.005 | 1 | 0.826 |
ERK7 |
0.733 | -0.008 | 2 | 0.466 |
TAK1 |
0.732 | 0.038 | 1 | 0.830 |
SLK |
0.730 | 0.037 | -2 | 0.676 |
VRK1 |
0.730 | 0.021 | 2 | 0.795 |
RIPK2 |
0.730 | 0.018 | 1 | 0.779 |
YSK1 |
0.730 | 0.051 | 2 | 0.761 |
NEK3 |
0.730 | 0.007 | 1 | 0.800 |
STK33 |
0.727 | -0.010 | 2 | 0.553 |
MST2 |
0.726 | -0.107 | 1 | 0.831 |
EEF2K |
0.726 | -0.033 | 3 | 0.792 |
CK1A |
0.725 | -0.088 | -3 | 0.050 |
CK2A2 |
0.724 | -0.022 | 1 | 0.679 |
PLK2 |
0.724 | -0.095 | -3 | 0.102 |
MEK2 |
0.723 | -0.103 | 2 | 0.778 |
MST1 |
0.722 | -0.073 | 1 | 0.817 |
YANK3 |
0.721 | 0.021 | 2 | 0.362 |
PDHK3_TYR |
0.719 | 0.109 | 4 | 0.868 |
BIKE |
0.718 | 0.049 | 1 | 0.750 |
LIMK2_TYR |
0.716 | 0.214 | -3 | 0.238 |
MYO3B |
0.715 | 0.020 | 2 | 0.773 |
CK2A1 |
0.714 | -0.027 | 1 | 0.657 |
TAO1 |
0.714 | 0.058 | 1 | 0.764 |
PKMYT1_TYR |
0.713 | 0.121 | 3 | 0.836 |
MAP2K4_TYR |
0.711 | 0.131 | -1 | 0.864 |
TTK |
0.711 | -0.023 | -2 | 0.745 |
TESK1_TYR |
0.711 | 0.098 | 3 | 0.857 |
ASK1 |
0.709 | -0.030 | 1 | 0.784 |
OSR1 |
0.708 | -0.074 | 2 | 0.765 |
AAK1 |
0.707 | 0.070 | 1 | 0.651 |
MAP2K7_TYR |
0.706 | 0.014 | 2 | 0.821 |
MYO3A |
0.705 | -0.020 | 1 | 0.829 |
PINK1_TYR |
0.705 | 0.165 | 1 | 0.835 |
MAP2K6_TYR |
0.705 | 0.002 | -1 | 0.858 |
CK1G3 |
0.703 | -0.099 | -3 | 0.046 |
LIMK1_TYR |
0.703 | 0.074 | 2 | 0.810 |
PDHK4_TYR |
0.702 | -0.058 | 2 | 0.855 |
ALPHAK3 |
0.702 | -0.054 | -1 | 0.737 |
BMPR2_TYR |
0.701 | -0.032 | -1 | 0.836 |
RET |
0.700 | 0.025 | 1 | 0.823 |
DDR1 |
0.699 | 0.066 | 4 | 0.794 |
PDHK1_TYR |
0.698 | -0.073 | -1 | 0.861 |
EPHA6 |
0.697 | 0.004 | -1 | 0.816 |
TNK2 |
0.696 | 0.063 | 3 | 0.744 |
TNK1 |
0.695 | 0.102 | 3 | 0.771 |
MST1R |
0.695 | -0.017 | 3 | 0.797 |
TNNI3K_TYR |
0.694 | 0.039 | 1 | 0.855 |
TYK2 |
0.693 | -0.077 | 1 | 0.826 |
ROS1 |
0.693 | -0.027 | 3 | 0.766 |
DDR2 |
0.692 | 0.137 | 3 | 0.724 |
EPHB4 |
0.692 | -0.044 | -1 | 0.801 |
STLK3 |
0.691 | -0.122 | 1 | 0.783 |
NEK10_TYR |
0.691 | 0.060 | 1 | 0.697 |
JAK2 |
0.691 | -0.100 | 1 | 0.826 |
TYRO3 |
0.690 | -0.081 | 3 | 0.784 |
ABL2 |
0.689 | -0.044 | -1 | 0.798 |
FGR |
0.688 | -0.076 | 1 | 0.828 |
CSF1R |
0.687 | -0.098 | 3 | 0.781 |
YES1 |
0.687 | -0.065 | -1 | 0.848 |
JAK1 |
0.686 | -0.024 | 1 | 0.782 |
TXK |
0.686 | -0.044 | 1 | 0.810 |
JAK3 |
0.684 | -0.079 | 1 | 0.791 |
ABL1 |
0.684 | -0.068 | -1 | 0.796 |
SRMS |
0.683 | -0.092 | 1 | 0.828 |
EPHA4 |
0.682 | -0.079 | 2 | 0.738 |
LCK |
0.682 | -0.062 | -1 | 0.806 |
INSRR |
0.681 | -0.064 | 3 | 0.731 |
PDGFRB |
0.681 | -0.052 | 3 | 0.791 |
AXL |
0.681 | -0.039 | 3 | 0.763 |
FER |
0.681 | -0.139 | 1 | 0.840 |
FGFR2 |
0.680 | -0.070 | 3 | 0.775 |
EPHB3 |
0.680 | -0.085 | -1 | 0.783 |
HCK |
0.680 | -0.116 | -1 | 0.806 |
ITK |
0.680 | -0.074 | -1 | 0.777 |
TEK |
0.680 | -0.077 | 3 | 0.718 |
EPHB1 |
0.680 | -0.105 | 1 | 0.830 |
KDR |
0.679 | -0.043 | 3 | 0.747 |
YANK2 |
0.679 | -0.053 | 2 | 0.379 |
BLK |
0.678 | -0.055 | -1 | 0.810 |
FLT3 |
0.678 | -0.065 | 3 | 0.779 |
EPHB2 |
0.677 | -0.101 | -1 | 0.774 |
KIT |
0.677 | -0.127 | 3 | 0.778 |
EPHA1 |
0.676 | -0.027 | 3 | 0.753 |
BMX |
0.676 | -0.058 | -1 | 0.704 |
ALK |
0.676 | -0.043 | 3 | 0.717 |
FGFR1 |
0.676 | -0.096 | 3 | 0.758 |
WEE1_TYR |
0.676 | -0.038 | -1 | 0.743 |
LTK |
0.675 | -0.026 | 3 | 0.742 |
BTK |
0.675 | -0.118 | -1 | 0.759 |
PDGFRA |
0.674 | -0.090 | 3 | 0.786 |
MERTK |
0.674 | -0.099 | 3 | 0.762 |
EPHA7 |
0.673 | -0.071 | 2 | 0.729 |
TEC |
0.673 | -0.084 | -1 | 0.735 |
CK1G2 |
0.672 | -0.100 | -3 | 0.063 |
MET |
0.672 | -0.100 | 3 | 0.770 |
PTK6 |
0.672 | -0.120 | -1 | 0.723 |
FYN |
0.671 | -0.075 | -1 | 0.786 |
PTK2B |
0.669 | -0.046 | -1 | 0.781 |
NTRK1 |
0.669 | -0.138 | -1 | 0.795 |
EPHA3 |
0.669 | -0.102 | 2 | 0.705 |
FLT1 |
0.666 | -0.121 | -1 | 0.773 |
LYN |
0.665 | -0.129 | 3 | 0.716 |
FGFR3 |
0.664 | -0.117 | 3 | 0.744 |
FRK |
0.664 | -0.122 | -1 | 0.807 |
INSR |
0.664 | -0.118 | 3 | 0.712 |
ERBB2 |
0.664 | -0.144 | 1 | 0.760 |
FLT4 |
0.663 | -0.111 | 3 | 0.738 |
NTRK2 |
0.663 | -0.158 | 3 | 0.730 |
NTRK3 |
0.662 | -0.130 | -1 | 0.748 |
MATK |
0.662 | -0.108 | -1 | 0.724 |
EPHA5 |
0.662 | -0.093 | 2 | 0.723 |
SRC |
0.661 | -0.104 | -1 | 0.795 |
EPHA8 |
0.660 | -0.102 | -1 | 0.757 |
CSK |
0.659 | -0.105 | 2 | 0.730 |
EGFR |
0.654 | -0.120 | 1 | 0.667 |
PTK2 |
0.653 | -0.069 | -1 | 0.725 |
FGFR4 |
0.651 | -0.127 | -1 | 0.733 |
SYK |
0.649 | -0.108 | -1 | 0.707 |
EPHA2 |
0.648 | -0.111 | -1 | 0.715 |
IGF1R |
0.645 | -0.128 | 3 | 0.652 |
MUSK |
0.644 | -0.122 | 1 | 0.645 |
ERBB4 |
0.642 | -0.109 | 1 | 0.680 |
FES |
0.634 | -0.146 | -1 | 0.688 |
ZAP70 |
0.627 | -0.098 | -1 | 0.649 |