Motif 345 (n=171)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| C9J069 | AJM1 | S468 | ochoa | Apical junction component 1 homolog | May be involved in the control of adherens junction integrity. {ECO:0000250|UniProtKB:A0A1C3NSL9}. |
| C9JH25 | PRRT4 | S766 | ochoa | Proline-rich transmembrane protein 4 | None |
| M0R1B8 | None | S54 | ochoa | Uncharacterized protein | None |
| O14490 | DLGAP1 | S932 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14893 | GEMIN2 | S81 | ochoa | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}. |
| O15067 | PFAS | S893 | ochoa | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O15234 | CASC3 | S66 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| O15553 | MEFV | S208 | psp | Pyrin (Marenostrin) | Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:16037825, PubMed:16785446, PubMed:17431422, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:26347139, PubMed:27030597, PubMed:28835462). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). {ECO:0000250|UniProtKB:Q9JJ26, ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11468188, ECO:0000269|PubMed:16037825, ECO:0000269|PubMed:16785446, ECO:0000269|PubMed:17431422, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18577712, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:27030597, ECO:0000269|PubMed:28835462}. |
| O43166 | SIPA1L1 | S1585 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43598 | DNPH1 | S123 | ochoa | 5-hydroxymethyl-dUMP N-hydrolase (EC 3.2.2.-) (2'-deoxynucleoside 5'-phosphate N-hydrolase 1) (c-Myc-responsive protein RCL) | Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration (PubMed:33833118). {ECO:0000269|PubMed:33833118}. |
| O43719 | HTATSF1 | S387 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60292 | SIPA1L3 | S1544 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60307 | MAST3 | S1223 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O60336 | MAPKBP1 | S827 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O75022 | LILRB3 | S503 | ochoa | Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (CD85 antigen-like family member A) (Immunoglobulin-like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD antigen CD85a) | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). {ECO:0000250|UniProtKB:P97484}. |
| O75179 | ANKRD17 | S206 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75382 | TRIM3 | S455 | ochoa | Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). {ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999}. |
| O75385 | ULK1 | S694 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O94823 | ATP10B | S510 | ochoa | Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}. |
| O95049 | TJP3 | S339 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95180 | CACNA1H | S1198 | psp | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
| O95685 | PPP1R3D | S74 | ochoa | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. |
| P02511 | CRYAB | S59 | ochoa|psp | Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component) | May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:P23927}. |
| P02686 | MBP | S96 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P06396 | GSN | S51 | ochoa | Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:19666512, ECO:0000269|PubMed:20393563}. |
| P07101 | TH | S19 | psp | Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) | Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}. |
| P07814 | EPRS1 | T467 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P08195 | SLC3A2 | S527 | psp | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P0DMV8 | HSPA1A | S40 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S40 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P11142 | HSPA8 | S40 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11831 | SRF | S103 | ochoa|psp | Serum response factor (SRF) | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}. |
| P12980 | LYL1 | S134 | ochoa | Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1) | None |
| P17066 | HSPA6 | S42 | ochoa | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P21580 | TNFAIP3 | S575 | ochoa | Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37] | Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. {ECO:0000269|PubMed:14748687, ECO:0000269|PubMed:15258597, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17961127, ECO:0000269|PubMed:18164316, ECO:0000269|PubMed:18952128, ECO:0000269|PubMed:19494296, ECO:0000269|PubMed:22099304, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:8692885, ECO:0000269|PubMed:9299557, ECO:0000269|PubMed:9882303}. |
| P28472 | GABRB3 | S433 | psp | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3) | Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:18514161, PubMed:22243422, PubMed:22303015, PubMed:24909990, PubMed:26950270, PubMed:30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:24909990, PubMed:30140029, PubMed:30602789). GABAARs containing beta-3/GABRB3 subunit are found at both synaptic and extrasynaptic sites (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:14993607, PubMed:22303015, PubMed:26950270, PubMed:30602789). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:22303015, PubMed:26950270). GABAARs containing alpha-1 and beta-3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:25489750). Extrasynaptic beta-3 receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs containing alpha-1, beta-3 and epsilon subunits may also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:18281286, PubMed:24909990, PubMed:35355020). Plays an important role in somatosensation and in the production of antinociception (By similarity). {ECO:0000250|UniProtKB:P63079, ECO:0000250|UniProtKB:P63080, ECO:0000269|PubMed:14993607, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:18514161, ECO:0000269|PubMed:22243422, ECO:0000269|PubMed:22303015, ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:26950270, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020}. |
| P28715 | ERCC5 | S705 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P34931 | HSPA1L | S42 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P48634 | PRRC2A | S1014 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48741 | HSPA7 | S42 | ochoa | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P49368 | CCT3 | S380 | ochoa | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51812 | RPS6KA3 | S386 | ochoa|psp | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| P54652 | HSPA2 | S41 | ochoa | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P55072 | VCP | S748 | psp | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| Q00587 | CDC42EP1 | S192 | ochoa|psp | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q08357 | SLC20A2 | S385 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q12802 | AKAP13 | S2498 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12888 | TP53BP1 | S1462 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13191 | CBLB | S800 | ochoa | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}. |
| Q13671 | RIN1 | S351 | ochoa|psp | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14005 | IL16 | S946 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14154 | DELE1 | S474 | ochoa | DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1) (cDELE1)] | Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks (PubMed:32132706, PubMed:32132707, PubMed:35388015, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). Detects impaired protein import and processing in mitochondria, activating the ISR (PubMed:35388015). May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:35388015, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}.; FUNCTION: [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. {ECO:0000269|PubMed:37327776}.; FUNCTION: [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546). Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy (PubMed:38340717). {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}. |
| Q14934 | NFATC4 | S335 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q15149 | PLEC | S2791 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15276 | RABEP1 | S407 | ochoa|psp | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}. |
| Q15349 | RPS6KA2 | S377 | ochoa | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q15418 | RPS6KA1 | S380 | ochoa|psp | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q15477 | SKIC2 | S256 | ochoa | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}. |
| Q15642 | TRIP10 | S296 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q15772 | SPEG | S2015 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q17RB8 | LONRF1 | S413 | ochoa | LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191) | None |
| Q2M3V2 | SOWAHA | S260 | ochoa | Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) | None |
| Q2V2M9 | FHOD3 | S345 | ochoa | FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) | Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269|PubMed:21149568}. |
| Q3KQU3 | MAP7D1 | S313 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3MII6 | TBC1D25 | S506 | ochoa | TBC1 domain family member 25 | Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269|PubMed:21383079}. |
| Q53ET0 | CRTC2 | S171 | ochoa|psp | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5T0Z8 | C6orf132 | S1106 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T1R4 | HIVEP3 | S542 | ochoa|psp | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T1R4 | HIVEP3 | S1050 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T1R4 | HIVEP3 | S2354 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T7N3 | KANK4 | S164 | ochoa | KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. {ECO:0000269|PubMed:17996375}. |
| Q5U651 | RASIP1 | S328 | ochoa | Ras-interacting protein 1 (Rain) | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}. |
| Q68CZ2 | TNS3 | S571 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q69YU3 | ANKRD34A | S473 | ochoa | Ankyrin repeat domain-containing protein 34A | None |
| Q6DN12 | MCTP2 | S49 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6DT37 | CDC42BPG | S1492 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6IPM2 | IQCE | S130 | ochoa | IQ domain-containing protein E | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}. |
| Q6JBY9 | RCSD1 | S244 | psp | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6P0Q8 | MAST2 | S1407 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P597 | KLC3 | S431 | ochoa | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}. |
| Q6PGN9 | PSRC1 | S47 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6R327 | RICTOR | S1408 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6UB99 | ANKRD11 | S1792 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UUV7 | CRTC3 | S162 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6UXY1 | BAIAP2L2 | S429 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6ZNJ1 | NBEAL2 | S759 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q76N89 | HECW1 | S874 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Q7L2K0 | TEDC2 | S159 | ochoa | Tubulin epsilon and delta complex protein 2 | Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability. {ECO:0000250|UniProtKB:Q6GQV0}. |
| Q7L7X3 | TAOK1 | S974 | ochoa | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7Z628 | NET1 | S51 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q86TI0 | TBC1D1 | S627 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86UU0 | BCL9L | S915 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UX7 | FERMT3 | S218 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86VI3 | IQGAP3 | S1424 | ochoa | Ras GTPase-activating-like protein IQGAP3 | None |
| Q86XR8 | CEP57 | S55 | ochoa | Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) | Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. {ECO:0000269|PubMed:22321063}. |
| Q86YV0 | RASAL3 | S865 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IVT2 | MISP | S394 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IVT5 | KSR1 | S406 | ochoa|psp | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8IWZ3 | ANKHD1 | S177 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8N350 | CBARP | S621 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N3V7 | SYNPO | S140 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8NC56 | LEMD2 | S134 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8NFW9 | MYRIP | S295 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8TAB5 | C1orf216 | S62 | ochoa | UPF0500 protein C1orf216 | None |
| Q8TE68 | EPS8L1 | S195 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TE77 | SSH3 | S37 | ochoa | Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}. |
| Q8TEK3 | DOT1L | S786 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TF40 | FNIP1 | S232 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8TF72 | SHROOM3 | S890 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUM9 | SLC20A1 | S417 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q8WWA1 | TMEM40 | S137 | ochoa | Transmembrane protein 40 | None |
| Q92974 | ARHGEF2 | S645 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q92974 | ARHGEF2 | S782 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q96BJ3 | AIDA | S162 | ochoa | Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist) | Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). {ECO:0000250}. |
| Q96CP6 | GRAMD1A | S285 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96E39 | RBMXL1 | S175 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96FS4 | SIPA1 | S55 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96J92 | WNK4 | S575 | psp | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) | Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}. |
| Q96JH8 | RADIL | S216 | ochoa | Ras-associating and dilute domain-containing protein | Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. |
| Q96N67 | DOCK7 | S929 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96S53 | TESK2 | S369 | ochoa | Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. |
| Q9BQ89 | FAM110A | S189 | ochoa | Protein FAM110A | None |
| Q9BRG2 | SH2D3A | S125 | ochoa | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | May play a role in JNK activation. |
| Q9BRG2 | SH2D3A | S180 | ochoa | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | May play a role in JNK activation. |
| Q9BV36 | MLPH | S552 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BYB0 | SHANK3 | S375 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZ23 | PANK2 | S168 | ochoa | Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)] | [Isoform 1]: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:17825826). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726). {ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:16272150, ECO:0000269|PubMed:17242360, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:30221726}.; FUNCTION: [Isoform 4]: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:16272150}. |
| Q9BZ67 | FRMD8 | S408 | ochoa | FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}. |
| Q9BZ71 | PITPNM3 | S928 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
| Q9BZ72 | PITPNM2 | S1298 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9BZL4 | PPP1R12C | S452 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0B5 | ZDHHC5 | S296 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9H0B6 | KLC2 | S545 | ochoa|psp | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H1B7 | IRF2BPL | S519 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H4B7 | TUBB1 | S285 | ochoa | Tubulin beta-1 chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9HB19 | PLEKHA2 | S184 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9HC44 | GPBP1L1 | S76 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9HC62 | SENP2 | S32 | ochoa | Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:15296745, PubMed:20194620, PubMed:21965678). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15296745, PubMed:20194620, PubMed:21965678). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity). {ECO:0000250|UniProtKB:Q91ZX6, ECO:0000269|PubMed:11896061, ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:15296745, ECO:0000269|PubMed:20194620, ECO:0000269|PubMed:21965678}. |
| Q9HCR9 | PDE11A | S117 | psp | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A) | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148). {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148, ECO:0000269|PubMed:16330539}. |
| Q9NRA0 | SPHK2 | S399 | ochoa | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
| Q9NRR6 | INPP5E | S85 | ochoa | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed:10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). {ECO:0000250|UniProtKB:Q9JII1, ECO:0000269|PubMed:10764818}. |
| Q9NSC5 | HOMER3 | S159 | ochoa | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
| Q9NVH1 | DNAJC11 | S204 | ochoa | DnaJ homolog subfamily C member 11 | [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180, ECO:0000305}. |
| Q9NY59 | SMPD3 | S209 | ochoa|psp | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NYF3 | FAM53C | S273 | ochoa | Protein FAM53C | None |
| Q9NZ09 | UBAP1 | S205 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
| Q9P1Y5 | CAMSAP3 | S431 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P206 | NHSL3 | S263 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P206 | NHSL3 | S858 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P227 | ARHGAP23 | S351 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2M4 | TBC1D14 | S91 | ochoa | TBC1 domain family member 14 | Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}. |
| Q9P2P5 | HECW2 | S852 | ochoa | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269|PubMed:12890487, ECO:0000269|PubMed:24163370}. |
| Q9UDY8 | MALT1 | S42 | ochoa | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) | Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). {ECO:0000250|UniProtKB:Q2TBA3, ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:31133753}. |
| Q9UJF2 | RASAL2 | S864 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UK80 | USP21 | S113 | ochoa | Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}. |
| Q9UKM9 | RALY | S106 | ochoa | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9ULH0 | KIDINS220 | S1681 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULJ3 | ZBTB21 | S345 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UPA5 | BSN | S2063 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9Y2J0 | RPH3A | S272 | ochoa | Rabphilin-3A (Exophilin-1) | Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). {ECO:0000250|UniProtKB:P47709}. |
| Q9Y446 | PKP3 | S280 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4G2 | PLEKHM1 | S482 | ochoa | Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) | Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}. |
| Q9Y608 | LRRFIP2 | S202 | psp | Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}. |
| Q9Y6R0 | NUMBL | S411 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| R4GMW8 | BIVM-ERCC5 | S1159 | ochoa | DNA excision repair protein ERCC-5 | None |
| P18858 | LIG1 | S901 | Sugiyama | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| O14545 | TRAFD1 | S191 | Sugiyama | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| Q8TD08 | MAPK15 | S503 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q9H093 | NUAK2 | S573 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| O95180 | CACNA1H | S2137 | SIGNOR | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
| Q9Y5U2 | TSSC4 | S87 | Sugiyama | U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) | Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.110223e-16 | 15.955 |
| R-HSA-2262752 | Cellular responses to stress | 9.055314e-07 | 6.043 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.333492e-06 | 5.875 |
| R-HSA-199920 | CREB phosphorylation | 1.902146e-04 | 3.721 |
| R-HSA-444257 | RSK activation | 3.412321e-04 | 3.467 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.458512e-04 | 3.461 |
| R-HSA-9833482 | PKR-mediated signaling | 7.409022e-04 | 3.130 |
| R-HSA-75893 | TNF signaling | 1.132234e-03 | 2.946 |
| R-HSA-73887 | Death Receptor Signaling | 1.221642e-03 | 2.913 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.951243e-03 | 2.403 |
| R-HSA-8854214 | TBC/RABGAPs | 3.507520e-03 | 2.455 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.965438e-03 | 2.528 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.162473e-03 | 2.500 |
| R-HSA-198753 | ERK/MAPK targets | 3.951243e-03 | 2.403 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.288390e-03 | 2.368 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 4.293641e-03 | 2.367 |
| R-HSA-437239 | Recycling pathway of L1 | 4.572705e-03 | 2.340 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.185388e-03 | 2.209 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 7.601466e-03 | 2.119 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 7.929059e-03 | 2.101 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.981609e-03 | 2.098 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 8.912925e-03 | 2.050 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 9.362724e-03 | 2.029 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.191128e-02 | 1.924 |
| R-HSA-1483226 | Synthesis of PI | 1.254621e-02 | 1.901 |
| R-HSA-166520 | Signaling by NTRKs | 1.563952e-02 | 1.806 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.826671e-02 | 1.738 |
| R-HSA-373760 | L1CAM interactions | 2.093414e-02 | 1.679 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.154851e-02 | 1.667 |
| R-HSA-8876725 | Protein methylation | 2.222614e-02 | 1.653 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.642334e-02 | 1.578 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.919781e-02 | 1.535 |
| R-HSA-9663891 | Selective autophagy | 3.015961e-02 | 1.521 |
| R-HSA-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | 3.532052e-02 | 1.452 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 3.532052e-02 | 1.452 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 3.532052e-02 | 1.452 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.246862e-02 | 1.372 |
| R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 4.681601e-02 | 1.330 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 5.817522e-02 | 1.235 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.792973e-02 | 1.319 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 5.089972e-02 | 1.293 |
| R-HSA-8875513 | MET interacts with TNS proteins | 5.817522e-02 | 1.235 |
| R-HSA-9612973 | Autophagy | 5.967282e-02 | 1.224 |
| R-HSA-983189 | Kinesins | 4.923503e-02 | 1.308 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.809143e-02 | 1.318 |
| R-HSA-450294 | MAP kinase activation | 5.100416e-02 | 1.292 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 6.018840e-02 | 1.220 |
| R-HSA-199991 | Membrane Trafficking | 6.060004e-02 | 1.218 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.307049e-02 | 1.200 |
| R-HSA-9615710 | Late endosomal microautophagy | 6.667753e-02 | 1.176 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 8.049119e-02 | 1.094 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 8.049119e-02 | 1.094 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 7.338700e-02 | 1.134 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 8.030284e-02 | 1.095 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 8.383394e-02 | 1.077 |
| R-HSA-174577 | Activation of C3 and C5 | 8.049119e-02 | 1.094 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 6.939975e-02 | 1.159 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.033677e-02 | 1.153 |
| R-HSA-112316 | Neuronal System | 7.158156e-02 | 1.145 |
| R-HSA-9733709 | Cardiogenesis | 8.030284e-02 | 1.095 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.454771e-02 | 1.128 |
| R-HSA-448424 | Interleukin-17 signaling | 6.827310e-02 | 1.166 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 7.681997e-02 | 1.115 |
| R-HSA-416482 | G alpha (12/13) signalling events | 8.554870e-02 | 1.068 |
| R-HSA-6806834 | Signaling by MET | 9.013202e-02 | 1.045 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 9.145111e-02 | 1.039 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 9.145111e-02 | 1.039 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 9.145111e-02 | 1.039 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 9.470050e-02 | 1.024 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 9.481603e-02 | 1.023 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 9.840855e-02 | 1.007 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 9.840855e-02 | 1.007 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.235572e-01 | 0.908 |
| R-HSA-170984 | ARMS-mediated activation | 1.340064e-01 | 0.873 |
| R-HSA-9613354 | Lipophagy | 1.340064e-01 | 0.873 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.094456e-01 | 0.961 |
| R-HSA-391251 | Protein folding | 1.248841e-01 | 0.903 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.340064e-01 | 0.873 |
| R-HSA-6798695 | Neutrophil degranulation | 1.228623e-01 | 0.911 |
| R-HSA-9646399 | Aggrephagy | 1.097692e-01 | 0.960 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.164076e-01 | 0.934 |
| R-HSA-1632852 | Macroautophagy | 1.232873e-01 | 0.909 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.129826e-01 | 0.947 |
| R-HSA-8875878 | MET promotes cell motility | 1.021570e-01 | 0.991 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.340064e-01 | 0.873 |
| R-HSA-447041 | CHL1 interactions | 1.129826e-01 | 0.947 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 1.175256e-01 | 0.930 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.059443e-01 | 0.975 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.021570e-01 | 0.991 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.334276e-01 | 0.875 |
| R-HSA-913531 | Interferon Signaling | 1.147173e-01 | 0.940 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.443316e-01 | 0.841 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.886134e-01 | 0.410 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.239851e-01 | 0.489 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.886134e-01 | 0.410 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.590828e-01 | 0.587 |
| R-HSA-5673000 | RAF activation | 3.886134e-01 | 0.410 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.102620e-01 | 0.387 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.844222e-01 | 0.734 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.319173e-01 | 0.635 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.410808e-01 | 0.618 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.766600e-01 | 0.558 |
| R-HSA-8949613 | Cristae formation | 3.269409e-01 | 0.486 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.429161e-01 | 0.465 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.585140e-01 | 0.445 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.410808e-01 | 0.618 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.410808e-01 | 0.618 |
| R-HSA-4641258 | Degradation of DVL | 4.102620e-01 | 0.387 |
| R-HSA-5617833 | Cilium Assembly | 2.427820e-01 | 0.615 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.443316e-01 | 0.841 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.941494e-01 | 0.712 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.539293e-01 | 0.813 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.623163e-01 | 0.581 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.646161e-01 | 0.784 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.410808e-01 | 0.618 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.501356e-01 | 0.602 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.590828e-01 | 0.587 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.349762e-01 | 0.475 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.844124e-01 | 0.546 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.094617e-01 | 0.388 |
| R-HSA-169893 | Prolonged ERK activation events | 2.132588e-01 | 0.671 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.188090e-01 | 0.496 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.646161e-01 | 0.784 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.020484e-01 | 0.520 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.443316e-01 | 0.841 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.534774e-01 | 0.596 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.646161e-01 | 0.784 |
| R-HSA-418457 | cGMP effects | 1.941494e-01 | 0.712 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.501356e-01 | 0.602 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.456539e-01 | 0.837 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.621004e-01 | 0.582 |
| R-HSA-8949664 | Processing of SMDT1 | 1.844222e-01 | 0.734 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.590828e-01 | 0.587 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 3.507617e-01 | 0.455 |
| R-HSA-190861 | Gap junction assembly | 3.886134e-01 | 0.410 |
| R-HSA-187687 | Signalling to ERKs | 3.959160e-01 | 0.402 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.319173e-01 | 0.635 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.383135e-01 | 0.859 |
| R-HSA-449836 | Other interleukin signaling | 2.501356e-01 | 0.602 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.443316e-01 | 0.841 |
| R-HSA-5689877 | Josephin domain DUBs | 1.443316e-01 | 0.841 |
| R-HSA-209905 | Catecholamine biosynthesis | 2.319173e-01 | 0.635 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.410808e-01 | 0.618 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.938223e-01 | 0.532 |
| R-HSA-9659379 | Sensory processing of sound | 2.799958e-01 | 0.553 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.941494e-01 | 0.712 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.037611e-01 | 0.691 |
| R-HSA-196783 | Coenzyme A biosynthesis | 2.226437e-01 | 0.652 |
| R-HSA-392517 | Rap1 signalling | 2.501356e-01 | 0.602 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.766600e-01 | 0.558 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.269409e-01 | 0.486 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.429161e-01 | 0.465 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.972306e-01 | 0.705 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.766600e-01 | 0.558 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.031319e-01 | 0.395 |
| R-HSA-5635838 | Activation of SMO | 2.132588e-01 | 0.671 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.319173e-01 | 0.635 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.501356e-01 | 0.602 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.269409e-01 | 0.486 |
| R-HSA-109581 | Apoptosis | 3.660684e-01 | 0.436 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.688353e-01 | 0.571 |
| R-HSA-111458 | Formation of apoptosome | 1.443316e-01 | 0.841 |
| R-HSA-9678110 | Attachment and Entry | 2.132588e-01 | 0.671 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.319173e-01 | 0.635 |
| R-HSA-210991 | Basigin interactions | 2.679239e-01 | 0.572 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.766600e-01 | 0.558 |
| R-HSA-419037 | NCAM1 interactions | 4.102620e-01 | 0.387 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.108406e-01 | 0.507 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.049436e-01 | 0.688 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.501356e-01 | 0.602 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.679239e-01 | 0.572 |
| R-HSA-9694614 | Attachment and Entry | 2.766600e-01 | 0.558 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.188090e-01 | 0.496 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.479419e-01 | 0.830 |
| R-HSA-5205647 | Mitophagy | 3.886134e-01 | 0.410 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.182024e-01 | 0.661 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.585140e-01 | 0.445 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.490605e-01 | 0.604 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.846941e-01 | 0.546 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.308958e-01 | 0.637 |
| R-HSA-622312 | Inflammasomes | 3.349762e-01 | 0.475 |
| R-HSA-69190 | DNA strand elongation | 3.661743e-01 | 0.436 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.138778e-01 | 0.670 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.812229e-01 | 0.419 |
| R-HSA-5619102 | SLC transporter disorders | 1.831579e-01 | 0.737 |
| R-HSA-5358508 | Mismatch Repair | 2.410808e-01 | 0.618 |
| R-HSA-264876 | Insulin processing | 3.269409e-01 | 0.486 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.938223e-01 | 0.532 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.886134e-01 | 0.410 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.084862e-01 | 0.681 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.446461e-01 | 0.611 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.737436e-01 | 0.427 |
| R-HSA-8853659 | RET signaling | 4.031319e-01 | 0.395 |
| R-HSA-9707616 | Heme signaling | 2.051526e-01 | 0.688 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.271462e-01 | 0.644 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.812229e-01 | 0.419 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.420684e-01 | 0.848 |
| R-HSA-75153 | Apoptotic execution phase | 1.374766e-01 | 0.862 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.752995e-01 | 0.756 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.031319e-01 | 0.395 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.888265e-01 | 0.539 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.438181e-01 | 0.842 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.438181e-01 | 0.842 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.438181e-01 | 0.842 |
| R-HSA-9675108 | Nervous system development | 2.989554e-01 | 0.524 |
| R-HSA-422475 | Axon guidance | 3.684978e-01 | 0.434 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.782529e-01 | 0.749 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.443838e-01 | 0.840 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.812200e-01 | 0.742 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.146681e-01 | 0.668 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.679239e-01 | 0.572 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.812200e-01 | 0.742 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.146681e-01 | 0.668 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.240132e-01 | 0.650 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.665252e-01 | 0.779 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.240132e-01 | 0.650 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.902003e-01 | 0.721 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.992921e-01 | 0.701 |
| R-HSA-1483255 | PI Metabolism | 3.927405e-01 | 0.406 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.465974e-01 | 0.834 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.204826e-01 | 0.494 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.173074e-01 | 0.380 |
| R-HSA-5688426 | Deubiquitination | 4.193319e-01 | 0.377 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.242690e-01 | 0.372 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.242690e-01 | 0.372 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.242690e-01 | 0.372 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.259571e-01 | 0.371 |
| R-HSA-2559583 | Cellular Senescence | 4.270152e-01 | 0.370 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.311479e-01 | 0.365 |
| R-HSA-71240 | Tryptophan catabolism | 4.311479e-01 | 0.365 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.364693e-01 | 0.360 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.379451e-01 | 0.359 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.379451e-01 | 0.359 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.379451e-01 | 0.359 |
| R-HSA-9694548 | Maturation of spike protein | 4.379451e-01 | 0.359 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.379451e-01 | 0.359 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.379451e-01 | 0.359 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.379451e-01 | 0.359 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.446614e-01 | 0.352 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.446614e-01 | 0.352 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.446614e-01 | 0.352 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.446614e-01 | 0.352 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.446614e-01 | 0.352 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.462353e-01 | 0.350 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.512978e-01 | 0.346 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.578554e-01 | 0.339 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.613871e-01 | 0.336 |
| R-HSA-190828 | Gap junction trafficking | 4.643350e-01 | 0.333 |
| R-HSA-68877 | Mitotic Prometaphase | 4.675441e-01 | 0.330 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.706110e-01 | 0.327 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.707376e-01 | 0.327 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.770640e-01 | 0.321 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.770640e-01 | 0.321 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.770640e-01 | 0.321 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.770640e-01 | 0.321 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.770640e-01 | 0.321 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.770640e-01 | 0.321 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.770640e-01 | 0.321 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.817055e-01 | 0.317 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.833152e-01 | 0.316 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.833152e-01 | 0.316 |
| R-HSA-5620924 | Intraflagellar transport | 4.894920e-01 | 0.310 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.894920e-01 | 0.310 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.894920e-01 | 0.310 |
| R-HSA-162582 | Signal Transduction | 4.955535e-01 | 0.305 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.955954e-01 | 0.305 |
| R-HSA-73893 | DNA Damage Bypass | 4.955954e-01 | 0.305 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.955954e-01 | 0.305 |
| R-HSA-72172 | mRNA Splicing | 5.038039e-01 | 0.298 |
| R-HSA-5357801 | Programmed Cell Death | 5.067693e-01 | 0.295 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.075853e-01 | 0.294 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.075853e-01 | 0.294 |
| R-HSA-72187 | mRNA 3'-end processing | 5.134734e-01 | 0.289 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.134734e-01 | 0.289 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.134734e-01 | 0.289 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.134734e-01 | 0.289 |
| R-HSA-1221632 | Meiotic synapsis | 5.192915e-01 | 0.285 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.192915e-01 | 0.285 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.192915e-01 | 0.285 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.192915e-01 | 0.285 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.192915e-01 | 0.285 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.192915e-01 | 0.285 |
| R-HSA-1483257 | Phospholipid metabolism | 5.230416e-01 | 0.281 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.250404e-01 | 0.280 |
| R-HSA-9909396 | Circadian clock | 5.304070e-01 | 0.275 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.307209e-01 | 0.275 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.363338e-01 | 0.271 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.363338e-01 | 0.271 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.363338e-01 | 0.271 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 5.363338e-01 | 0.271 |
| R-HSA-177929 | Signaling by EGFR | 5.363338e-01 | 0.271 |
| R-HSA-68882 | Mitotic Anaphase | 5.387684e-01 | 0.269 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.416190e-01 | 0.266 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.418799e-01 | 0.266 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.473600e-01 | 0.262 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.473600e-01 | 0.262 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.473600e-01 | 0.262 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.527749e-01 | 0.257 |
| R-HSA-191859 | snRNP Assembly | 5.527749e-01 | 0.257 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.527749e-01 | 0.257 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.527749e-01 | 0.257 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.527749e-01 | 0.257 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.527749e-01 | 0.257 |
| R-HSA-180786 | Extension of Telomeres | 5.527749e-01 | 0.257 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.547885e-01 | 0.256 |
| R-HSA-168249 | Innate Immune System | 5.561358e-01 | 0.255 |
| R-HSA-379724 | tRNA Aminoacylation | 5.581254e-01 | 0.253 |
| R-HSA-977443 | GABA receptor activation | 5.581254e-01 | 0.253 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.581254e-01 | 0.253 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.634121e-01 | 0.249 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.634121e-01 | 0.249 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 5.635663e-01 | 0.249 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.686360e-01 | 0.245 |
| R-HSA-1268020 | Mitochondrial protein import | 5.686360e-01 | 0.245 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.686360e-01 | 0.245 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.686360e-01 | 0.245 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.737976e-01 | 0.241 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.737976e-01 | 0.241 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.759238e-01 | 0.240 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.788978e-01 | 0.237 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.839373e-01 | 0.234 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.889168e-01 | 0.230 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.889168e-01 | 0.230 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.938370e-01 | 0.226 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.938370e-01 | 0.226 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.986986e-01 | 0.223 |
| R-HSA-5218859 | Regulated Necrosis | 5.986986e-01 | 0.223 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.082488e-01 | 0.216 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 6.082488e-01 | 0.216 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.129388e-01 | 0.213 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.175729e-01 | 0.209 |
| R-HSA-74259 | Purine catabolism | 6.175729e-01 | 0.209 |
| R-HSA-162587 | HIV Life Cycle | 6.212689e-01 | 0.207 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.221518e-01 | 0.206 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.221518e-01 | 0.206 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.266762e-01 | 0.203 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.266762e-01 | 0.203 |
| R-HSA-877300 | Interferon gamma signaling | 6.274346e-01 | 0.202 |
| R-HSA-380287 | Centrosome maturation | 6.311467e-01 | 0.200 |
| R-HSA-8852135 | Protein ubiquitination | 6.311467e-01 | 0.200 |
| R-HSA-1280218 | Adaptive Immune System | 6.314748e-01 | 0.200 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.399285e-01 | 0.194 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.425092e-01 | 0.192 |
| R-HSA-5619084 | ABC transporter disorders | 6.442410e-01 | 0.191 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.527127e-01 | 0.185 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.568729e-01 | 0.183 |
| R-HSA-977225 | Amyloid fiber formation | 6.568729e-01 | 0.183 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.609836e-01 | 0.180 |
| R-HSA-416476 | G alpha (q) signalling events | 6.634053e-01 | 0.178 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.690585e-01 | 0.175 |
| R-HSA-73894 | DNA Repair | 6.698799e-01 | 0.174 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.712168e-01 | 0.173 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.730239e-01 | 0.172 |
| R-HSA-1500620 | Meiosis | 6.730239e-01 | 0.172 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.769420e-01 | 0.169 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.769420e-01 | 0.169 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.769420e-01 | 0.169 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.958431e-01 | 0.157 |
| R-HSA-202424 | Downstream TCR signaling | 6.958431e-01 | 0.157 |
| R-HSA-73884 | Base Excision Repair | 6.958431e-01 | 0.157 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.958431e-01 | 0.157 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.969878e-01 | 0.157 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.033934e-01 | 0.153 |
| R-HSA-69275 | G2/M Transition | 7.057267e-01 | 0.151 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.066513e-01 | 0.151 |
| R-HSA-168256 | Immune System | 7.092512e-01 | 0.149 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.107610e-01 | 0.148 |
| R-HSA-983712 | Ion channel transport | 7.132513e-01 | 0.147 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.136437e-01 | 0.147 |
| R-HSA-1474290 | Collagen formation | 7.136437e-01 | 0.147 |
| R-HSA-68886 | M Phase | 7.137865e-01 | 0.146 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.170774e-01 | 0.144 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.179402e-01 | 0.144 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.204702e-01 | 0.142 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.206149e-01 | 0.142 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.238225e-01 | 0.140 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.238225e-01 | 0.140 |
| R-HSA-157579 | Telomere Maintenance | 7.271348e-01 | 0.138 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.319321e-01 | 0.136 |
| R-HSA-195721 | Signaling by WNT | 7.358288e-01 | 0.133 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.368365e-01 | 0.133 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.368365e-01 | 0.133 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.368365e-01 | 0.133 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.399935e-01 | 0.131 |
| R-HSA-428157 | Sphingolipid metabolism | 7.417593e-01 | 0.130 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.462692e-01 | 0.127 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.492402e-01 | 0.125 |
| R-HSA-418346 | Platelet homeostasis | 7.581597e-01 | 0.120 |
| R-HSA-69239 | Synthesis of DNA | 7.610622e-01 | 0.119 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.639300e-01 | 0.117 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.639300e-01 | 0.117 |
| R-HSA-202403 | TCR signaling | 7.695633e-01 | 0.114 |
| R-HSA-1640170 | Cell Cycle | 7.745123e-01 | 0.111 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.750629e-01 | 0.111 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.750629e-01 | 0.111 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.804318e-01 | 0.108 |
| R-HSA-166663 | Initial triggering of complement | 7.830683e-01 | 0.106 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.882472e-01 | 0.103 |
| R-HSA-449147 | Signaling by Interleukins | 7.896598e-01 | 0.103 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.933030e-01 | 0.101 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.957857e-01 | 0.099 |
| R-HSA-5693538 | Homology Directed Repair | 7.957857e-01 | 0.099 |
| R-HSA-162906 | HIV Infection | 7.971731e-01 | 0.098 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.982387e-01 | 0.098 |
| R-HSA-68875 | Mitotic Prophase | 8.006625e-01 | 0.097 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.008297e-01 | 0.096 |
| R-HSA-73886 | Chromosome Maintenance | 8.030572e-01 | 0.095 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 8.077612e-01 | 0.093 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.100711e-01 | 0.091 |
| R-HSA-977606 | Regulation of Complement cascade | 8.123534e-01 | 0.090 |
| R-HSA-15869 | Metabolism of nucleotides | 8.131738e-01 | 0.090 |
| R-HSA-194138 | Signaling by VEGF | 8.146084e-01 | 0.089 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.179705e-01 | 0.087 |
| R-HSA-114608 | Platelet degranulation | 8.190378e-01 | 0.087 |
| R-HSA-69481 | G2/M Checkpoints | 8.190378e-01 | 0.087 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.208101e-01 | 0.086 |
| R-HSA-8956319 | Nucleotide catabolism | 8.233620e-01 | 0.084 |
| R-HSA-1474165 | Reproduction | 8.275833e-01 | 0.082 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.337279e-01 | 0.079 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.352492e-01 | 0.078 |
| R-HSA-9609646 | HCMV Infection | 8.358389e-01 | 0.078 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.434885e-01 | 0.074 |
| R-HSA-388396 | GPCR downstream signalling | 8.439127e-01 | 0.074 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.447730e-01 | 0.073 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.453711e-01 | 0.073 |
| R-HSA-6807070 | PTEN Regulation | 8.472311e-01 | 0.072 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.476521e-01 | 0.072 |
| R-HSA-109582 | Hemostasis | 8.527795e-01 | 0.069 |
| R-HSA-382551 | Transport of small molecules | 8.539159e-01 | 0.069 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.544515e-01 | 0.068 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.579333e-01 | 0.067 |
| R-HSA-166658 | Complement cascade | 8.596430e-01 | 0.066 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.630012e-01 | 0.064 |
| R-HSA-69242 | S Phase | 8.646502e-01 | 0.063 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.647209e-01 | 0.063 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.694798e-01 | 0.061 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.710512e-01 | 0.060 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.726038e-01 | 0.059 |
| R-HSA-9609507 | Protein localization | 8.726038e-01 | 0.059 |
| R-HSA-69306 | DNA Replication | 8.726038e-01 | 0.059 |
| R-HSA-9610379 | HCMV Late Events | 8.786305e-01 | 0.056 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.800923e-01 | 0.055 |
| R-HSA-9711097 | Cellular response to starvation | 8.800923e-01 | 0.055 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.829636e-01 | 0.054 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.885025e-01 | 0.051 |
| R-HSA-8953854 | Metabolism of RNA | 8.918962e-01 | 0.050 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.928658e-01 | 0.049 |
| R-HSA-72306 | tRNA processing | 8.975754e-01 | 0.047 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.988101e-01 | 0.046 |
| R-HSA-418555 | G alpha (s) signalling events | 8.988101e-01 | 0.046 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.000300e-01 | 0.046 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.036026e-01 | 0.044 |
| R-HSA-372790 | Signaling by GPCR | 9.058749e-01 | 0.043 |
| R-HSA-168255 | Influenza Infection | 9.081693e-01 | 0.042 |
| R-HSA-1266738 | Developmental Biology | 9.137441e-01 | 0.039 |
| R-HSA-9609690 | HCMV Early Events | 9.252948e-01 | 0.034 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.288384e-01 | 0.032 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.305470e-01 | 0.031 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.313859e-01 | 0.031 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.313859e-01 | 0.031 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.324378e-01 | 0.030 |
| R-HSA-6805567 | Keratinization | 9.346420e-01 | 0.029 |
| R-HSA-397014 | Muscle contraction | 9.392401e-01 | 0.027 |
| R-HSA-8951664 | Neddylation | 9.455406e-01 | 0.024 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.499880e-01 | 0.022 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.511909e-01 | 0.022 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.535111e-01 | 0.021 |
| R-HSA-8939211 | ESR-mediated signaling | 9.551790e-01 | 0.020 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.551790e-01 | 0.020 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.569478e-01 | 0.019 |
| R-HSA-4839726 | Chromatin organization | 9.612758e-01 | 0.017 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.673533e-01 | 0.014 |
| R-HSA-9824446 | Viral Infection Pathways | 9.686019e-01 | 0.014 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.692855e-01 | 0.014 |
| R-HSA-9679506 | SARS-CoV Infections | 9.702173e-01 | 0.013 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.703509e-01 | 0.013 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.714545e-01 | 0.013 |
| R-HSA-72766 | Translation | 9.724284e-01 | 0.012 |
| R-HSA-446728 | Cell junction organization | 9.728151e-01 | 0.012 |
| R-HSA-9658195 | Leishmania infection | 9.737931e-01 | 0.012 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.737931e-01 | 0.012 |
| R-HSA-1500931 | Cell-Cell communication | 9.829172e-01 | 0.007 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.836034e-01 | 0.007 |
| R-HSA-1474244 | Extracellular matrix organization | 9.857839e-01 | 0.006 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.903987e-01 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.905159e-01 | 0.004 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.973002e-01 | 0.001 |
| R-HSA-5663205 | Infectious disease | 9.990514e-01 | 0.000 |
| R-HSA-597592 | Post-translational protein modification | 9.995699e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.996945e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.998135e-01 | 0.000 |
| R-HSA-1643685 | Disease | 9.999778e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999974e-01 | 0.000 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.999992e-01 | 0.000 |
| R-HSA-212436 | Generic Transcription Pathway | 9.999994e-01 | 0.000 |
| R-HSA-74160 | Gene expression (Transcription) | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MAPKAPK2 |
0.776 | 0.561 | -3 | 0.684 |
SBK |
0.776 | 0.668 | -3 | 0.837 |
PRKD3 |
0.774 | 0.682 | -3 | 0.674 |
PRKD2 |
0.773 | 0.598 | -3 | 0.630 |
RSK2 |
0.773 | 0.563 | -3 | 0.685 |
SRPK2 |
0.772 | 0.538 | -3 | 0.793 |
P90RSK |
0.771 | 0.595 | -3 | 0.688 |
MAPKAPK3 |
0.769 | 0.577 | -3 | 0.602 |
RSK3 |
0.769 | 0.549 | -3 | 0.682 |
PRKD1 |
0.769 | 0.584 | -3 | 0.536 |
CAMK1A |
0.768 | 0.660 | -3 | 0.748 |
CAMK1D |
0.765 | 0.639 | -3 | 0.714 |
MSK1 |
0.764 | 0.500 | -3 | 0.690 |
MSK2 |
0.764 | 0.542 | -3 | 0.703 |
AKT2 |
0.763 | 0.566 | -3 | 0.765 |
SRPK1 |
0.763 | 0.502 | -3 | 0.726 |
RSK4 |
0.763 | 0.513 | -3 | 0.713 |
CHK2 |
0.762 | 0.668 | -3 | 0.782 |
SIK |
0.762 | 0.548 | -3 | 0.607 |
MAPKAPK5 |
0.759 | 0.582 | -3 | 0.681 |
AMPKA2 |
0.759 | 0.528 | -3 | 0.541 |
PRKX |
0.759 | 0.441 | -3 | 0.714 |
SGK1 |
0.757 | 0.575 | -3 | 0.828 |
PKACA |
0.757 | 0.442 | -2 | 0.645 |
AKT3 |
0.757 | 0.544 | -3 | 0.819 |
SRPK3 |
0.755 | 0.493 | -3 | 0.726 |
CDKL5 |
0.755 | 0.506 | -3 | 0.659 |
NUAK2 |
0.755 | 0.524 | -3 | 0.544 |
NUAK1 |
0.755 | 0.520 | -3 | 0.591 |
PIM1 |
0.754 | 0.522 | -3 | 0.654 |
CLK1 |
0.754 | 0.471 | -3 | 0.680 |
AMPKA1 |
0.754 | 0.500 | -3 | 0.482 |
CDKL1 |
0.754 | 0.580 | -3 | 0.637 |
TSSK1 |
0.753 | 0.501 | -3 | 0.463 |
PKACB |
0.753 | 0.405 | -2 | 0.691 |
CAMK1G |
0.752 | 0.563 | -3 | 0.654 |
NDR2 |
0.752 | 0.318 | -3 | 0.487 |
AKT1 |
0.751 | 0.511 | -3 | 0.729 |
CLK4 |
0.751 | 0.463 | -3 | 0.679 |
QSK |
0.750 | 0.440 | 4 | 0.924 |
BRSK1 |
0.750 | 0.457 | -3 | 0.591 |
CAMK2A |
0.748 | 0.431 | 2 | 0.823 |
CAMK1B |
0.748 | 0.582 | -3 | 0.494 |
PIM3 |
0.748 | 0.436 | -3 | 0.565 |
P70S6KB |
0.748 | 0.471 | -3 | 0.616 |
MYLK4 |
0.748 | 0.446 | -2 | 0.781 |
P70S6K |
0.748 | 0.509 | -3 | 0.714 |
PKACG |
0.748 | 0.364 | -2 | 0.750 |
SGK3 |
0.746 | 0.472 | -3 | 0.635 |
PIM2 |
0.746 | 0.514 | -3 | 0.697 |
PKN3 |
0.746 | 0.447 | -3 | 0.536 |
NDR1 |
0.746 | 0.383 | -3 | 0.522 |
CAMK2D |
0.746 | 0.410 | -3 | 0.467 |
LATS2 |
0.746 | 0.280 | -5 | 0.286 |
MELK |
0.745 | 0.511 | -3 | 0.554 |
CLK2 |
0.745 | 0.425 | -3 | 0.715 |
HIPK4 |
0.745 | 0.372 | 1 | 0.679 |
TSSK2 |
0.744 | 0.481 | -5 | 0.524 |
CAMK4 |
0.744 | 0.444 | -3 | 0.501 |
CHK1 |
0.742 | 0.486 | -3 | 0.445 |
PKN1 |
0.740 | 0.517 | -3 | 0.689 |
BRSK2 |
0.739 | 0.382 | -3 | 0.508 |
CAMK2B |
0.739 | 0.361 | 2 | 0.812 |
PKG2 |
0.738 | 0.329 | -2 | 0.687 |
ICK |
0.737 | 0.444 | -3 | 0.574 |
QIK |
0.737 | 0.415 | -3 | 0.451 |
MARK4 |
0.737 | 0.295 | 4 | 0.923 |
DYRK1A |
0.735 | 0.410 | 1 | 0.644 |
AURC |
0.734 | 0.225 | -2 | 0.677 |
MARK3 |
0.734 | 0.328 | 4 | 0.913 |
DYRK3 |
0.734 | 0.406 | 1 | 0.624 |
CLK3 |
0.733 | 0.236 | 1 | 0.754 |
WNK1 |
0.733 | 0.274 | -2 | 0.851 |
PKN2 |
0.733 | 0.360 | -3 | 0.481 |
SKMLCK |
0.733 | 0.315 | -2 | 0.857 |
MARK2 |
0.732 | 0.330 | 4 | 0.888 |
MARK1 |
0.732 | 0.354 | 4 | 0.911 |
DAPK2 |
0.732 | 0.470 | -3 | 0.462 |
CRIK |
0.732 | 0.528 | -3 | 0.742 |
CAMLCK |
0.732 | 0.405 | -2 | 0.815 |
PKG1 |
0.731 | 0.391 | -2 | 0.609 |
DCAMKL1 |
0.730 | 0.460 | -3 | 0.592 |
HIPK1 |
0.730 | 0.348 | 1 | 0.619 |
AURB |
0.730 | 0.244 | -2 | 0.673 |
CDC7 |
0.729 | 0.105 | 1 | 0.845 |
DYRK2 |
0.728 | 0.266 | 1 | 0.606 |
PHKG1 |
0.727 | 0.350 | -3 | 0.519 |
MRCKA |
0.726 | 0.451 | -3 | 0.633 |
MNK2 |
0.726 | 0.236 | -2 | 0.773 |
SMMLCK |
0.726 | 0.462 | -3 | 0.566 |
MRCKB |
0.726 | 0.461 | -3 | 0.664 |
DAPK1 |
0.725 | 0.458 | -3 | 0.642 |
HIPK3 |
0.725 | 0.349 | 1 | 0.626 |
HIPK2 |
0.725 | 0.269 | 1 | 0.504 |
NIK |
0.723 | 0.407 | -3 | 0.385 |
DAPK3 |
0.722 | 0.453 | -3 | 0.608 |
MNK1 |
0.722 | 0.244 | -2 | 0.781 |
AURA |
0.722 | 0.212 | -2 | 0.652 |
PAK6 |
0.722 | 0.201 | -2 | 0.694 |
LATS1 |
0.721 | 0.272 | -3 | 0.454 |
NIM1 |
0.721 | 0.238 | 3 | 0.755 |
PAK1 |
0.721 | 0.241 | -2 | 0.780 |
SSTK |
0.720 | 0.302 | 4 | 0.898 |
DMPK1 |
0.720 | 0.474 | -3 | 0.643 |
MOS |
0.719 | 0.093 | 1 | 0.856 |
PAK3 |
0.719 | 0.229 | -2 | 0.772 |
PKCD |
0.719 | 0.264 | 2 | 0.747 |
MOK |
0.719 | 0.439 | 1 | 0.623 |
DCAMKL2 |
0.718 | 0.372 | -3 | 0.557 |
MAK |
0.718 | 0.377 | -2 | 0.687 |
DYRK1B |
0.718 | 0.264 | 1 | 0.560 |
PHKG2 |
0.717 | 0.338 | -3 | 0.532 |
PDHK4 |
0.716 | -0.039 | 1 | 0.846 |
PAK2 |
0.715 | 0.241 | -2 | 0.762 |
PAK5 |
0.715 | 0.232 | -2 | 0.646 |
IKKB |
0.715 | 0.006 | -2 | 0.685 |
SNRK |
0.714 | 0.261 | 2 | 0.669 |
COT |
0.714 | -0.052 | 2 | 0.846 |
DYRK4 |
0.714 | 0.220 | 1 | 0.531 |
PASK |
0.714 | 0.371 | -3 | 0.500 |
RAF1 |
0.714 | 0.084 | 1 | 0.839 |
NLK |
0.714 | 0.101 | 1 | 0.757 |
MTOR |
0.714 | -0.038 | 1 | 0.783 |
WNK3 |
0.713 | 0.114 | 1 | 0.797 |
HUNK |
0.713 | 0.062 | 2 | 0.797 |
ATR |
0.713 | 0.049 | 1 | 0.769 |
MST4 |
0.712 | 0.112 | 2 | 0.801 |
PRPK |
0.712 | -0.053 | -1 | 0.793 |
CAMK2G |
0.712 | 0.017 | 2 | 0.834 |
PKCB |
0.711 | 0.231 | 2 | 0.686 |
ROCK2 |
0.711 | 0.418 | -3 | 0.598 |
TBK1 |
0.711 | -0.029 | 1 | 0.777 |
PAK4 |
0.711 | 0.216 | -2 | 0.651 |
PKCE |
0.709 | 0.324 | 2 | 0.677 |
PDHK1 |
0.709 | -0.047 | 1 | 0.842 |
GRK1 |
0.708 | 0.020 | -2 | 0.807 |
RIPK1 |
0.708 | 0.159 | 1 | 0.769 |
PKCH |
0.708 | 0.242 | 2 | 0.678 |
ROCK1 |
0.708 | 0.430 | -3 | 0.639 |
PKCG |
0.708 | 0.193 | 2 | 0.690 |
BCKDK |
0.708 | -0.017 | -1 | 0.749 |
PKCT |
0.707 | 0.292 | 2 | 0.686 |
TGFBR2 |
0.706 | 0.036 | -2 | 0.690 |
IKKE |
0.706 | -0.051 | 1 | 0.778 |
MASTL |
0.705 | 0.035 | -2 | 0.751 |
RIPK3 |
0.705 | 0.025 | 3 | 0.692 |
GRK6 |
0.704 | 0.016 | 1 | 0.851 |
PKCA |
0.704 | 0.170 | 2 | 0.681 |
WNK4 |
0.704 | 0.237 | -2 | 0.834 |
CK1E |
0.703 | -0.021 | -3 | 0.144 |
BUB1 |
0.703 | 0.352 | -5 | 0.616 |
GCN2 |
0.702 | -0.117 | 2 | 0.790 |
GRK5 |
0.702 | -0.080 | -3 | 0.227 |
DSTYK |
0.702 | -0.120 | 2 | 0.860 |
PKCI |
0.702 | 0.244 | 2 | 0.708 |
BMPR2 |
0.701 | -0.151 | -2 | 0.784 |
ERK5 |
0.701 | 0.002 | 1 | 0.742 |
PKCZ |
0.701 | 0.161 | 2 | 0.744 |
KIS |
0.700 | -0.005 | 1 | 0.600 |
CK1A2 |
0.700 | -0.015 | -3 | 0.144 |
DLK |
0.698 | 0.077 | 1 | 0.836 |
CK1D |
0.698 | -0.022 | -3 | 0.121 |
ATM |
0.698 | 0.023 | 1 | 0.713 |
ULK2 |
0.697 | -0.136 | 2 | 0.763 |
GRK4 |
0.697 | -0.071 | -2 | 0.799 |
IKKA |
0.694 | -0.104 | -2 | 0.670 |
CHAK2 |
0.694 | -0.054 | -1 | 0.786 |
NEK7 |
0.693 | -0.140 | -3 | 0.197 |
TTBK2 |
0.693 | -0.058 | 2 | 0.682 |
CDK7 |
0.693 | 0.025 | 1 | 0.575 |
DNAPK |
0.693 | 0.029 | 1 | 0.667 |
CDK10 |
0.691 | 0.127 | 1 | 0.523 |
CK1G1 |
0.691 | -0.049 | -3 | 0.133 |
IRE1 |
0.690 | 0.032 | 1 | 0.720 |
ANKRD3 |
0.690 | -0.006 | 1 | 0.825 |
MLK1 |
0.690 | -0.098 | 2 | 0.769 |
SMG1 |
0.690 | -0.035 | 1 | 0.714 |
ULK1 |
0.689 | -0.154 | -3 | 0.174 |
ALK4 |
0.689 | -0.033 | -2 | 0.732 |
MEK1 |
0.689 | 0.004 | 2 | 0.813 |
GRK7 |
0.689 | 0.014 | 1 | 0.789 |
TGFBR1 |
0.689 | -0.039 | -2 | 0.707 |
FAM20C |
0.688 | 0.008 | 2 | 0.644 |
DRAK1 |
0.688 | 0.091 | 1 | 0.736 |
NEK6 |
0.688 | -0.145 | -2 | 0.758 |
NEK9 |
0.688 | -0.117 | 2 | 0.802 |
BMPR1B |
0.687 | -0.020 | 1 | 0.790 |
CDK14 |
0.686 | 0.093 | 1 | 0.548 |
NEK2 |
0.686 | -0.059 | 2 | 0.779 |
CDK8 |
0.686 | -0.041 | 1 | 0.587 |
PDK1 |
0.686 | 0.244 | 1 | 0.777 |
CDK19 |
0.684 | -0.032 | 1 | 0.544 |
ALK2 |
0.683 | -0.031 | -2 | 0.725 |
GRK2 |
0.682 | -0.025 | -2 | 0.691 |
VRK2 |
0.682 | -0.064 | 1 | 0.835 |
PKR |
0.682 | 0.008 | 1 | 0.779 |
CHAK1 |
0.682 | -0.044 | 2 | 0.752 |
MLK2 |
0.681 | -0.128 | 2 | 0.781 |
YSK4 |
0.681 | -0.081 | 1 | 0.793 |
P38A |
0.681 | 0.004 | 1 | 0.609 |
IRE2 |
0.681 | -0.008 | 2 | 0.723 |
ACVR2A |
0.679 | -0.056 | -2 | 0.664 |
JNK2 |
0.679 | 0.001 | 1 | 0.528 |
CDK9 |
0.679 | -0.000 | 1 | 0.561 |
GRK3 |
0.679 | -0.015 | -2 | 0.672 |
ACVR2B |
0.679 | -0.075 | -2 | 0.687 |
MST3 |
0.678 | 0.046 | 2 | 0.790 |
PLK1 |
0.677 | -0.089 | -2 | 0.678 |
CDK18 |
0.677 | -0.001 | 1 | 0.501 |
IRAK4 |
0.676 | 0.026 | 1 | 0.743 |
MEK5 |
0.676 | -0.003 | 2 | 0.790 |
CDK12 |
0.676 | 0.001 | 1 | 0.528 |
IRAK1 |
0.676 | -0.004 | -1 | 0.710 |
CDK13 |
0.676 | -0.029 | 1 | 0.552 |
TTBK1 |
0.675 | -0.048 | 2 | 0.608 |
BRAF |
0.675 | -0.012 | -4 | 0.641 |
PRP4 |
0.675 | -0.056 | -3 | 0.204 |
JNK3 |
0.675 | -0.029 | 1 | 0.574 |
PLK3 |
0.674 | -0.090 | 2 | 0.774 |
MEKK3 |
0.674 | -0.055 | 1 | 0.799 |
MPSK1 |
0.674 | 0.005 | 1 | 0.678 |
P38B |
0.673 | -0.014 | 1 | 0.556 |
TLK1 |
0.672 | -0.055 | -2 | 0.751 |
PERK |
0.672 | -0.069 | -2 | 0.733 |
MLK3 |
0.672 | -0.093 | 2 | 0.693 |
HPK1 |
0.671 | 0.089 | 1 | 0.769 |
PLK4 |
0.671 | -0.064 | 2 | 0.621 |
BMPR1A |
0.671 | -0.040 | 1 | 0.784 |
HRI |
0.671 | -0.075 | -2 | 0.738 |
TLK2 |
0.670 | -0.126 | 1 | 0.763 |
ZAK |
0.670 | -0.068 | 1 | 0.807 |
GSK3B |
0.669 | 0.012 | 4 | 0.405 |
MEKK6 |
0.669 | 0.054 | 1 | 0.797 |
CDK1 |
0.669 | -0.037 | 1 | 0.537 |
MEKK1 |
0.668 | -0.122 | 1 | 0.805 |
NEK11 |
0.668 | -0.049 | 1 | 0.785 |
GAK |
0.668 | 0.023 | 1 | 0.769 |
CDK2 |
0.668 | -0.048 | 1 | 0.639 |
TAO3 |
0.668 | -0.010 | 1 | 0.787 |
PBK |
0.667 | 0.071 | 1 | 0.694 |
ERK1 |
0.667 | -0.034 | 1 | 0.535 |
NEK5 |
0.667 | -0.102 | 1 | 0.785 |
RIPK2 |
0.667 | 0.038 | 1 | 0.758 |
ERK2 |
0.667 | -0.034 | 1 | 0.582 |
LRRK2 |
0.667 | 0.106 | 2 | 0.822 |
GCK |
0.667 | 0.023 | 1 | 0.782 |
CDK17 |
0.666 | -0.023 | 1 | 0.458 |
P38G |
0.666 | -0.027 | 1 | 0.456 |
NEK8 |
0.666 | -0.000 | 2 | 0.785 |
TAO2 |
0.665 | 0.010 | 2 | 0.811 |
CK1A |
0.665 | -0.052 | -3 | 0.092 |
CDK5 |
0.665 | -0.043 | 1 | 0.587 |
MEKK2 |
0.665 | -0.082 | 2 | 0.770 |
LKB1 |
0.665 | -0.093 | -3 | 0.224 |
MLK4 |
0.664 | -0.128 | 2 | 0.682 |
MAP3K15 |
0.664 | -0.003 | 1 | 0.785 |
LOK |
0.663 | 0.056 | -2 | 0.712 |
CK2A2 |
0.663 | -0.007 | 1 | 0.735 |
CAMKK2 |
0.662 | -0.094 | -2 | 0.676 |
PINK1 |
0.662 | -0.142 | 1 | 0.711 |
KHS1 |
0.662 | 0.054 | 1 | 0.775 |
KHS2 |
0.661 | 0.077 | 1 | 0.772 |
TAK1 |
0.659 | 0.004 | 1 | 0.796 |
GSK3A |
0.659 | -0.010 | 4 | 0.413 |
CDK16 |
0.659 | -0.016 | 1 | 0.476 |
NEK4 |
0.659 | -0.067 | 1 | 0.763 |
CDK4 |
0.659 | 0.034 | 1 | 0.514 |
EEF2K |
0.658 | -0.029 | 3 | 0.788 |
MINK |
0.657 | -0.031 | 1 | 0.784 |
HGK |
0.657 | -0.024 | 3 | 0.808 |
NEK1 |
0.657 | -0.031 | 1 | 0.769 |
VRK1 |
0.656 | -0.033 | 2 | 0.824 |
CAMKK1 |
0.655 | -0.178 | -2 | 0.680 |
SLK |
0.655 | -0.010 | -2 | 0.658 |
HASPIN |
0.655 | 0.069 | -1 | 0.646 |
CDK3 |
0.655 | -0.030 | 1 | 0.475 |
ERK7 |
0.655 | -0.010 | 2 | 0.539 |
YANK3 |
0.655 | 0.024 | 2 | 0.395 |
TNIK |
0.655 | -0.020 | 3 | 0.808 |
MST2 |
0.654 | -0.107 | 1 | 0.811 |
P38D |
0.654 | -0.036 | 1 | 0.458 |
PLK2 |
0.654 | -0.082 | -3 | 0.151 |
CK2A1 |
0.654 | -0.013 | 1 | 0.715 |
STK33 |
0.653 | -0.041 | 2 | 0.595 |
JNK1 |
0.651 | -0.039 | 1 | 0.528 |
NEK3 |
0.651 | -0.031 | 1 | 0.759 |
YSK1 |
0.651 | -0.004 | 2 | 0.768 |
MEK2 |
0.650 | -0.114 | 2 | 0.782 |
MST1 |
0.649 | -0.083 | 1 | 0.794 |
CK1G3 |
0.648 | -0.060 | -3 | 0.083 |
CDK6 |
0.646 | -0.026 | 1 | 0.522 |
PDHK3_TYR |
0.643 | 0.062 | 4 | 0.849 |
BIKE |
0.640 | 0.011 | 1 | 0.635 |
TAO1 |
0.639 | 0.016 | 1 | 0.739 |
MAP2K4_TYR |
0.637 | 0.047 | -1 | 0.798 |
TESK1_TYR |
0.637 | 0.047 | 3 | 0.850 |
ASK1 |
0.637 | -0.056 | 1 | 0.783 |
LIMK2_TYR |
0.635 | 0.098 | -3 | 0.299 |
PKMYT1_TYR |
0.634 | 0.027 | 3 | 0.819 |
MAP2K7_TYR |
0.634 | -0.007 | 2 | 0.845 |
MYO3B |
0.634 | -0.037 | 2 | 0.781 |
DDR1 |
0.632 | 0.062 | 4 | 0.793 |
PINK1_TYR |
0.632 | 0.090 | 1 | 0.815 |
TTK |
0.631 | -0.059 | -2 | 0.717 |
BMPR2_TYR |
0.631 | -0.033 | -1 | 0.785 |
MAP2K6_TYR |
0.630 | -0.055 | -1 | 0.804 |
PDHK4_TYR |
0.630 | -0.066 | 2 | 0.866 |
PDHK1_TYR |
0.629 | -0.061 | -1 | 0.803 |
RET |
0.629 | 0.008 | 1 | 0.810 |
ALPHAK3 |
0.628 | -0.070 | -1 | 0.678 |
CK1G2 |
0.627 | -0.048 | -3 | 0.105 |
AAK1 |
0.627 | 0.029 | 1 | 0.518 |
LIMK1_TYR |
0.627 | 0.020 | 2 | 0.831 |
OSR1 |
0.627 | -0.130 | 2 | 0.757 |
EPHA6 |
0.626 | -0.010 | -1 | 0.772 |
MST1R |
0.625 | 0.006 | 3 | 0.749 |
EPHB4 |
0.624 | -0.033 | -1 | 0.763 |
TNK2 |
0.623 | 0.023 | 3 | 0.702 |
TYK2 |
0.622 | -0.056 | 1 | 0.817 |
MYO3A |
0.622 | -0.085 | 1 | 0.751 |
FGR |
0.622 | -0.048 | 1 | 0.826 |
TNK1 |
0.621 | 0.060 | 3 | 0.731 |
TYRO3 |
0.621 | -0.060 | 3 | 0.743 |
ROS1 |
0.621 | -0.037 | 3 | 0.717 |
TNNI3K_TYR |
0.620 | 0.045 | 1 | 0.808 |
DDR2 |
0.620 | 0.108 | 3 | 0.685 |
EPHB1 |
0.619 | -0.038 | 1 | 0.874 |
EPHA4 |
0.618 | -0.037 | 2 | 0.774 |
FER |
0.617 | -0.082 | 1 | 0.870 |
JAK2 |
0.617 | -0.085 | 1 | 0.816 |
STLK3 |
0.616 | -0.145 | 1 | 0.769 |
SRMS |
0.615 | -0.070 | 1 | 0.869 |
EPHB2 |
0.615 | -0.052 | -1 | 0.743 |
JAK3 |
0.615 | -0.064 | 1 | 0.809 |
EPHB3 |
0.615 | -0.050 | -1 | 0.755 |
NEK10_TYR |
0.614 | 0.011 | 1 | 0.683 |
ABL2 |
0.614 | -0.063 | -1 | 0.727 |
FGFR2 |
0.614 | -0.045 | 3 | 0.747 |
YES1 |
0.614 | -0.087 | -1 | 0.774 |
PDGFRB |
0.614 | -0.034 | 3 | 0.744 |
BTK |
0.614 | -0.065 | -1 | 0.728 |
FLT3 |
0.614 | -0.034 | 3 | 0.737 |
INSRR |
0.613 | -0.051 | 3 | 0.692 |
TXK |
0.613 | -0.056 | 1 | 0.839 |
EPHA1 |
0.613 | 0.010 | 3 | 0.692 |
AXL |
0.613 | -0.026 | 3 | 0.710 |
TEK |
0.613 | -0.040 | 3 | 0.681 |
JAK1 |
0.613 | -0.025 | 1 | 0.785 |
HCK |
0.613 | -0.079 | -1 | 0.762 |
YANK2 |
0.613 | -0.039 | 2 | 0.409 |
CSF1R |
0.612 | -0.115 | 3 | 0.721 |
ABL1 |
0.612 | -0.066 | -1 | 0.719 |
ITK |
0.612 | -0.068 | -1 | 0.746 |
PDGFRA |
0.611 | -0.035 | 3 | 0.736 |
LCK |
0.611 | -0.064 | -1 | 0.765 |
LTK |
0.611 | 0.002 | 3 | 0.696 |
KDR |
0.610 | -0.040 | 3 | 0.690 |
MERTK |
0.610 | -0.054 | 3 | 0.714 |
FGFR1 |
0.609 | -0.063 | 3 | 0.713 |
WEE1_TYR |
0.609 | -0.018 | -1 | 0.703 |
ALK |
0.609 | -0.019 | 3 | 0.671 |
EPHA3 |
0.609 | -0.042 | 2 | 0.749 |
EPHA7 |
0.608 | -0.041 | 2 | 0.770 |
BMX |
0.607 | -0.040 | -1 | 0.659 |
BLK |
0.606 | -0.068 | -1 | 0.755 |
ERBB2 |
0.605 | -0.063 | 1 | 0.821 |
KIT |
0.605 | -0.116 | 3 | 0.728 |
FYN |
0.605 | -0.056 | -1 | 0.741 |
TEC |
0.605 | -0.065 | -1 | 0.675 |
PTK2B |
0.604 | -0.024 | -1 | 0.710 |
NTRK1 |
0.604 | -0.103 | -1 | 0.751 |
MET |
0.604 | -0.082 | 3 | 0.721 |
FRK |
0.603 | -0.063 | -1 | 0.767 |
EPHA5 |
0.602 | -0.045 | 2 | 0.763 |
PTK6 |
0.601 | -0.105 | -1 | 0.682 |
FLT1 |
0.601 | -0.091 | -1 | 0.742 |
FGFR3 |
0.600 | -0.087 | 3 | 0.712 |
NTRK2 |
0.600 | -0.108 | 3 | 0.682 |
FLT4 |
0.599 | -0.073 | 3 | 0.696 |
INSR |
0.599 | -0.086 | 3 | 0.672 |
LYN |
0.598 | -0.096 | 3 | 0.668 |
SYK |
0.597 | -0.035 | -1 | 0.688 |
NTRK3 |
0.597 | -0.099 | -1 | 0.709 |
EPHA8 |
0.597 | -0.063 | -1 | 0.722 |
EGFR |
0.596 | -0.060 | 1 | 0.762 |
SRC |
0.595 | -0.087 | -1 | 0.726 |
PTK2 |
0.594 | -0.026 | -1 | 0.701 |
CSK |
0.594 | -0.078 | 2 | 0.770 |
MATK |
0.593 | -0.091 | -1 | 0.648 |
MUSK |
0.593 | -0.038 | 1 | 0.741 |
ERBB4 |
0.587 | -0.046 | 1 | 0.775 |
EPHA2 |
0.587 | -0.067 | -1 | 0.687 |
FGFR4 |
0.584 | -0.104 | -1 | 0.679 |
IGF1R |
0.583 | -0.088 | 3 | 0.621 |
FES |
0.575 | -0.095 | -1 | 0.632 |
ZAP70 |
0.571 | -0.059 | -1 | 0.613 |