Motif 343 (n=116)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
B9A064 | IGLL5 | S194 | ochoa | Immunoglobulin lambda-like polypeptide 5 (G lambda-1) (Germline immunoglobulin lambda 1) | None |
E9PAV3 | NACA | S738 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
O00220 | TNFRSF10A | S424 | ochoa | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9430227}. |
O14490 | DLGAP1 | S493 | ochoa|psp | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
O14639 | ABLIM1 | S631 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
O15344 | MID1 | S311 | ochoa | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}. |
O15360 | FANCA | S347 | psp | Fanconi anemia group A protein (Protein FACA) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
O43318 | MAP3K7 | S375 | ochoa | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
O60658 | PDE8A | S359 | psp | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). {ECO:0000269|PubMed:18983167, ECO:0000269|PubMed:23509299}. |
O94875 | SORBS2 | S843 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
O95721 | SNAP29 | S78 | ochoa | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
P04049 | RAF1 | S621 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
P04183 | TK1 | S63 | ochoa | Thymidine kinase, cytosolic (EC 2.7.1.21) | Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). {ECO:0000269|PubMed:22385435, ECO:0000269|PubMed:9575153, ECO:0000305|PubMed:17407781}. |
P0CF74 | IGLC6 | S86 | ochoa | Immunoglobulin lambda constant 6 (Ig lambda-6 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
P0CG04 | IGLC1 | S86 | ochoa | Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
P0DOY2 | IGLC2 | S86 | ochoa | Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
P0DOY3 | IGLC3 | S86 | ochoa | Immunoglobulin lambda constant 3 (Ig lambda chain C region DOT) (Ig lambda chain C region NEWM) (Ig lambda-3 chain C regions) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
P10398 | ARAF | S582 | ochoa|psp | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
P15056 | BRAF | S729 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
P22459 | KCNA4 | T601 | psp | Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). {ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:27582084, ECO:0000269|PubMed:8495559}. |
P26045 | PTPN3 | S835 | psp | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
P32942 | ICAM3 | S518 | ochoa|psp | Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50) | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000269|PubMed:1448173, ECO:0000269|PubMed:23775590}. |
P35367 | HRH1 | S398 | psp | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
P35612 | ADD2 | S532 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
P38398 | BRCA1 | S1101 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
P43405 | SYK | S178 | psp | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
P46527 | CDKN1B | S140 | ochoa|psp | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}. |
P49327 | FASN | S1727 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
P52179 | MYOM1 | S1399 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
P55198 | MLLT6 | S279 | ochoa | Protein AF-17 (ALL1-fused gene from chromosome 17 protein) | None |
P57075 | UBASH3A | S384 | ochoa | Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318, ECO:0000269|PubMed:18189269}. |
Q00610 | CLTC | S1229 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
Q00872 | MYBPC1 | S906 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
Q01432 | AMPD3 | S85 | ochoa | AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) | AMP deaminase plays a critical role in energy metabolism. {ECO:0000305|PubMed:9291127}. |
Q12879 | GRIN2A | S1291 | psp | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:20890276, ECO:0000269|PubMed:23933818, ECO:0000269|PubMed:23933819, ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:24504326, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27288002, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28182669, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:29644724, ECO:0000269|PubMed:36117210, ECO:0000269|PubMed:38307912, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
Q12933 | TRAF2 | S55 | psp | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:10346818, PubMed:11784851, PubMed:12917689, PubMed:15383523, PubMed:18981220, PubMed:19150425, PubMed:19810754, PubMed:19918265, PubMed:19937093, PubMed:20047764, PubMed:20064526, PubMed:20385093, PubMed:20577214, PubMed:22212761). Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1 (PubMed:23453969, PubMed:28489822). Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases (PubMed:15383523, PubMed:18981220). Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain (PubMed:11907583, PubMed:19506082). Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR (PubMed:15121867). In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE (PubMed:23453969). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex (PubMed:28489822). Required for normal antibody isotype switching from IgM to IgG (By similarity). {ECO:0000250|UniProtKB:P39429, ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, ECO:0000269|PubMed:19150425, ECO:0000269|PubMed:19506082, ECO:0000269|PubMed:19810754, ECO:0000269|PubMed:19918265, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20047764, ECO:0000269|PubMed:20064526, ECO:0000269|PubMed:20385093, ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:22212761, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:28489822}. |
Q13009 | TIAM1 | S172 | ochoa|psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
Q13023 | AKAP6 | S1655 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
Q13796 | SHROOM2 | S897 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
Q14451 | GRB7 | S368 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
Q14766 | LTBP1 | S536 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
Q2M1Z3 | ARHGAP31 | S272 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
Q2PPJ7 | RALGAPA2 | S766 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Q49A26 | GLYR1 | S114 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
Q53QZ3 | ARHGAP15 | S212 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
Q5BKX6 | SLC45A4 | S456 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
Q5JRC9 | FAM47A | S542 | ochoa | Protein FAM47A | None |
Q5T1Q4 | SLC35F1 | S374 | ochoa | Solute carrier family 35 member F1 | Putative solute transporter. {ECO:0000305}. |
Q5T5Y3 | CAMSAP1 | S827 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
Q5VWN6 | TASOR2 | S221 | ochoa | Protein TASOR 2 | None |
Q6AI14 | SLC9A4 | S660 | ochoa | Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) | Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity). {ECO:0000250|UniProtKB:P26434, ECO:0000250|UniProtKB:Q8BUE1}. |
Q6NYC1 | JMJD6 | S381 | ochoa | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}. |
Q6P995 | FAM171B | S405 | ochoa | Protein FAM171B | None |
Q6ZQN7 | SLCO4C1 | S79 | ochoa | Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) | Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}. |
Q70EL2 | USP45 | S599 | ochoa | Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45) | Catalyzes the deubiquitination of SPDL1 (PubMed:30258100). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (PubMed:30258100). {ECO:0000250|UniProtKB:E9QG68, ECO:0000269|PubMed:25538220, ECO:0000269|PubMed:30258100, ECO:0000269|PubMed:30573563}. |
Q7Z7E8 | UBE2Q1 | S268 | ochoa | Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1) | Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). {ECO:0000250|UniProtKB:Q7TSS2, ECO:0000269|PubMed:22496338}. |
Q8IVL0 | NAV3 | S275 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
Q8IVL0 | NAV3 | S1448 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
Q8IVL1 | NAV2 | S1538 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
Q8IX21 | SLF2 | S653 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
Q8IXI1 | RHOT2 | S156 | psp | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
Q8IZ21 | PHACTR4 | S443 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
Q8IZW8 | TNS4 | S198 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
Q8N1W1 | ARHGEF28 | S624 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
Q8N1W1 | ARHGEF28 | S1538 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
Q8N4Y2 | CRACR2B | S307 | ochoa | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}. |
Q8NBA8 | DTWD2 | S132 | ochoa | tRNA-uridine aminocarboxypropyltransferase 2 (EC 2.5.1.25) (DTW domain-containing protein 2) | Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502, PubMed:39173631). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). Involved in glycoRNA biosynthesis by mediating formation of acp3U, which acts as an attachment site for N-glycans on tRNAs (PubMed:39173631). GlycoRNAs consist of RNAs modified with secretory N-glycans that are presented on the cell surface (PubMed:39173631). {ECO:0000269|PubMed:31804502, ECO:0000269|PubMed:39173631}. |
Q8NCN4 | RNF169 | S292 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
Q8NDX5 | PHC3 | S228 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
Q8NEY1 | NAV1 | S1048 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
Q8NF91 | SYNE1 | S5919 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
Q8TE67 | EPS8L3 | S420 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
Q96A65 | EXOC4 | S410 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
Q96B18 | DACT3 | S426 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
Q96LR2 | LURAP1 | S126 | ochoa | Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A) | Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250|UniProtKB:D4A8G3, ECO:0000269|PubMed:21048106}. |
Q96MK2 | RIPOR3 | S397 | ochoa | RIPOR family member 3 | None |
Q96P20 | NLRP3 | S295 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
Q96T37 | RBM15 | S873 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
Q99704 | DOK1 | S460 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
Q99963 | SH3GL3 | S265 | ochoa | Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
Q9BRR9 | ARHGAP9 | S144 | ochoa | Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}. |
Q9BVI0 | PHF20 | S265 | ochoa|psp | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
Q9BZ95 | NSD3 | S424 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
Q9BZF3 | OSBPL6 | S195 | ochoa | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. |
Q9GZY8 | MFF | S179 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
Q9H2G2 | SLK | S1094 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
Q9H582 | ZNF644 | S199 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
Q9H5P4 | PDZD7 | S436 | ochoa | PDZ domain-containing protein 7 | In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. {ECO:0000250|UniProtKB:E9Q9W7}. |
Q9H792 | PEAK1 | S1250 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
Q9H7D0 | DOCK5 | S1656 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
Q9H7U1 | CCSER2 | S223 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
Q9HAW4 | CLSPN | S723 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
Q9HB21 | PLEKHA1 | S299 | ochoa | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}. |
Q9NQC3 | RTN4 | S993 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
Q9NQG6 | MIEF1 | S94 | ochoa | Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) | Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33632269}. |
Q9NR09 | BIRC6 | S3742 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
Q9NV58 | RNF19A | S284 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
Q9NY74 | ETAA1 | S344 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
Q9NYL2 | MAP3K20 | S567 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
Q9NZN5 | ARHGEF12 | S41 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
Q9P212 | PLCE1 | S67 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
Q9P266 | JCAD | S757 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
Q9P270 | SLAIN2 | S435 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
Q9P273 | TENM3 | S111 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
Q9UBP0 | SPAST | S597 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
Q9UH92 | MLX | S74 | ochoa | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
Q9UHQ4 | BCAP29 | S74 | ochoa | B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29) | May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity). {ECO:0000250}. |
Q9UKV8 | AGO2 | S387 | ochoa|psp | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}. |
Q9ULV3 | CIZ1 | S868 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
Q9UPQ0 | LIMCH1 | S493 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9UQB8 | BAIAP2 | S338 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
Q9Y5X3 | SNX5 | S22 | ochoa | Sorting nexin-5 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}. |
Q9Y620 | RAD54B | S64 | Sugiyama | DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B) | Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. {ECO:0000269|PubMed:11782437, ECO:0000269|PubMed:11884632}. |
P11717 | IGF2R | S1378 | Sugiyama | Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}. |
Q6UXD5 | SEZ6L2 | S719 | Sugiyama | Seizure 6-like protein 2 | May contribute to specialized endoplasmic reticulum functions in neurons. {ECO:0000250}. |
Q8NB16 | MLKL | S360 | SIGNOR | Mixed lineage kinase domain-like protein (hMLKL) | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.000079 | 4.103 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.000104 | 3.981 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.000104 | 3.981 |
R-HSA-163765 | ChREBP activates metabolic gene expression | 0.000212 | 3.674 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.000697 | 3.157 |
R-HSA-2029481 | FCGR activation | 0.001529 | 2.816 |
R-HSA-9664407 | Parasite infection | 0.001761 | 2.754 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.001761 | 2.754 |
R-HSA-9664417 | Leishmania phagocytosis | 0.001761 | 2.754 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.001818 | 2.740 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.001529 | 2.816 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.001804 | 2.744 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.001954 | 2.709 |
R-HSA-5218900 | CASP8 activity is inhibited | 0.004305 | 2.366 |
R-HSA-9700645 | ALK mutants bind TKIs | 0.004305 | 2.366 |
R-HSA-3371378 | Regulation by c-FLIP | 0.003637 | 2.439 |
R-HSA-5690714 | CD22 mediated BCR regulation | 0.002824 | 2.549 |
R-HSA-69416 | Dimerization of procaspase-8 | 0.003637 | 2.439 |
R-HSA-5673000 | RAF activation | 0.004543 | 2.343 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.004821 | 2.317 |
R-HSA-5675482 | Regulation of necroptotic cell death | 0.003956 | 2.403 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.004098 | 2.387 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.003999 | 2.398 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.003093 | 2.510 |
R-HSA-73887 | Death Receptor Signaling | 0.002764 | 2.558 |
R-HSA-9658195 | Leishmania infection | 0.003079 | 2.512 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.003079 | 2.512 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.003637 | 2.439 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.003999 | 2.398 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.003387 | 2.470 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.004865 | 2.313 |
R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.005027 | 2.299 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.005518 | 2.258 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.005785 | 2.238 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.005869 | 2.231 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.006233 | 2.205 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.007405 | 2.130 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.007405 | 2.130 |
R-HSA-9607240 | FLT3 Signaling | 0.007001 | 2.155 |
R-HSA-173623 | Classical antibody-mediated complement activation | 0.007988 | 2.098 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.009629 | 2.016 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.009629 | 2.016 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.009629 | 2.016 |
R-HSA-6802949 | Signaling by RAS mutants | 0.009629 | 2.016 |
R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.009389 | 2.027 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.009274 | 2.033 |
R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.008419 | 2.075 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.010153 | 1.993 |
R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.011472 | 1.940 |
R-HSA-168249 | Innate Immune System | 0.011412 | 1.943 |
R-HSA-2168880 | Scavenging of heme from plasma | 0.010785 | 1.967 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.011730 | 1.931 |
R-HSA-6794361 | Neurexins and neuroligins | 0.012761 | 1.894 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.013333 | 1.875 |
R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.015895 | 1.799 |
R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.015895 | 1.799 |
R-HSA-844456 | The NLRP3 inflammasome | 0.016180 | 1.791 |
R-HSA-166786 | Creation of C4 and C2 activators | 0.015403 | 1.812 |
R-HSA-166663 | Initial triggering of complement | 0.019576 | 1.708 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.019691 | 1.706 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.019691 | 1.706 |
R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.020163 | 1.695 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.020586 | 1.686 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.021334 | 1.671 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.024509 | 1.611 |
R-HSA-5218859 | Regulated Necrosis | 0.023665 | 1.626 |
R-HSA-162582 | Signal Transduction | 0.023966 | 1.620 |
R-HSA-977606 | Regulation of Complement cascade | 0.026135 | 1.583 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.027600 | 1.559 |
R-HSA-5689901 | Metalloprotease DUBs | 0.027600 | 1.559 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.027600 | 1.559 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.029201 | 1.535 |
R-HSA-182971 | EGFR downregulation | 0.035962 | 1.444 |
R-HSA-622312 | Inflammasomes | 0.030839 | 1.511 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.032391 | 1.490 |
R-HSA-5653656 | Vesicle-mediated transport | 0.034663 | 1.460 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.031453 | 1.502 |
R-HSA-5357801 | Programmed Cell Death | 0.035466 | 1.450 |
R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.046937 | 1.328 |
R-HSA-75158 | TRAIL signaling | 0.062092 | 1.207 |
R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.062092 | 1.207 |
R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.069579 | 1.158 |
R-HSA-9732724 | IFNG signaling activates MAPKs | 0.077008 | 1.113 |
R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.084377 | 1.074 |
R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.084377 | 1.074 |
R-HSA-196025 | Formation of annular gap junctions | 0.084377 | 1.074 |
R-HSA-190873 | Gap junction degradation | 0.091688 | 1.038 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.106136 | 0.974 |
R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.113275 | 0.946 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.127382 | 0.895 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.134352 | 0.872 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.141267 | 0.850 |
R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.148127 | 0.829 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.175028 | 0.757 |
R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.181620 | 0.741 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.181620 | 0.741 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.181620 | 0.741 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.181620 | 0.741 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.181620 | 0.741 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.188160 | 0.725 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.207471 | 0.683 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.039367 | 1.405 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.194649 | 0.711 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.113275 | 0.946 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.154933 | 0.810 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.160047 | 0.796 |
R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.054545 | 1.263 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.134352 | 0.872 |
R-HSA-1221632 | Meiotic synapsis | 0.086495 | 1.063 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.139714 | 0.855 |
R-HSA-6798695 | Neutrophil degranulation | 0.186121 | 0.730 |
R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.194649 | 0.711 |
R-HSA-75893 | TNF signaling | 0.093781 | 1.028 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.049064 | 1.309 |
R-HSA-8875513 | MET interacts with TNS proteins | 0.039269 | 1.406 |
R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.077008 | 1.113 |
R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.084377 | 1.074 |
R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.098941 | 1.005 |
R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.098941 | 1.005 |
R-HSA-8866427 | VLDLR internalisation and degradation | 0.120357 | 0.920 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.127382 | 0.895 |
R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.141267 | 0.850 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.047100 | 1.327 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.213806 | 0.670 |
R-HSA-170968 | Frs2-mediated activation | 0.127382 | 0.895 |
R-HSA-912631 | Regulation of signaling by CBL | 0.175028 | 0.757 |
R-HSA-169893 | Prolonged ERK activation events | 0.148127 | 0.829 |
R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.127382 | 0.895 |
R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.091688 | 1.038 |
R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.134352 | 0.872 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.148127 | 0.829 |
R-HSA-193697 | p75NTR regulates axonogenesis | 0.091688 | 1.038 |
R-HSA-8849932 | Synaptic adhesion-like molecules | 0.168383 | 0.774 |
R-HSA-1500620 | Meiosis | 0.171332 | 0.766 |
R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.062092 | 1.207 |
R-HSA-446107 | Type I hemidesmosome assembly | 0.084377 | 1.074 |
R-HSA-170984 | ARMS-mediated activation | 0.091688 | 1.038 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.188160 | 0.725 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.072486 | 1.140 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.039367 | 1.405 |
R-HSA-390650 | Histamine receptors | 0.039269 | 1.406 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.181620 | 0.741 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.070230 | 1.153 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.070230 | 1.153 |
R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.046937 | 1.328 |
R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.084377 | 1.074 |
R-HSA-425986 | Sodium/Proton exchangers | 0.084377 | 1.074 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.141267 | 0.850 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.194649 | 0.711 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.075479 | 1.122 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.075479 | 1.122 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.068465 | 1.165 |
R-HSA-5683057 | MAPK family signaling cascades | 0.172730 | 0.763 |
R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.077008 | 1.113 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.091688 | 1.038 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.067316 | 1.172 |
R-HSA-877300 | Interferon gamma signaling | 0.170064 | 0.769 |
R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.106136 | 0.974 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.127382 | 0.895 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.181620 | 0.741 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.188160 | 0.725 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.194649 | 0.711 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.065748 | 1.182 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.137945 | 0.860 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.151680 | 0.819 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.065789 | 1.182 |
R-HSA-199991 | Membrane Trafficking | 0.169314 | 0.771 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.145256 | 0.838 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.148991 | 0.827 |
R-HSA-4086398 | Ca2+ pathway | 0.137945 | 0.860 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.141267 | 0.850 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.161685 | 0.791 |
R-HSA-163685 | Integration of energy metabolism | 0.125308 | 0.902 |
R-HSA-69206 | G1/S Transition | 0.103168 | 0.986 |
R-HSA-177929 | Signaling by EGFR | 0.093781 | 1.028 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.072486 | 1.140 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.071233 | 1.147 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.205879 | 0.686 |
R-HSA-73894 | DNA Repair | 0.190244 | 0.721 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.071233 | 1.147 |
R-HSA-6807004 | Negative regulation of MET activity | 0.181620 | 0.741 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.207471 | 0.683 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.125308 | 0.902 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.194649 | 0.711 |
R-HSA-8964038 | LDL clearance | 0.201085 | 0.697 |
R-HSA-392517 | Rap1 signalling | 0.175028 | 0.757 |
R-HSA-193648 | NRAGE signals death through JNK | 0.093781 | 1.028 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.049360 | 1.307 |
R-HSA-1280218 | Adaptive Immune System | 0.086538 | 1.063 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.077068 | 1.113 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.077068 | 1.113 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.211714 | 0.674 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.108129 | 0.966 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.184642 | 0.734 |
R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.077008 | 1.113 |
R-HSA-5689880 | Ub-specific processing proteases | 0.200066 | 0.699 |
R-HSA-168256 | Immune System | 0.080390 | 1.095 |
R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.148127 | 0.829 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.120357 | 0.920 |
R-HSA-879518 | Organic anion transport by SLCO transporters | 0.207471 | 0.683 |
R-HSA-9020558 | Interleukin-2 signaling | 0.106136 | 0.974 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.140019 | 0.854 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.047041 | 1.328 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.091688 | 1.038 |
R-HSA-9629569 | Protein hydroxylation | 0.181620 | 0.741 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.217565 | 0.662 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.217565 | 0.662 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.217565 | 0.662 |
R-HSA-166520 | Signaling by NTRKs | 0.045231 | 1.345 |
R-HSA-166658 | Complement cascade | 0.042808 | 1.368 |
R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.148127 | 0.829 |
R-HSA-8956321 | Nucleotide salvage | 0.106296 | 0.973 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.111423 | 0.953 |
R-HSA-5688426 | Deubiquitination | 0.071140 | 1.148 |
R-HSA-418885 | DCC mediated attractive signaling | 0.141267 | 0.850 |
R-HSA-8853659 | RET signaling | 0.047100 | 1.327 |
R-HSA-9645723 | Diseases of programmed cell death | 0.182744 | 0.738 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.059179 | 1.228 |
R-HSA-8848021 | Signaling by PTK6 | 0.111423 | 0.953 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.111423 | 0.953 |
R-HSA-69205 | G1/S-Specific Transcription | 0.047100 | 1.327 |
R-HSA-210993 | Tie2 Signaling | 0.168383 | 0.774 |
R-HSA-422475 | Axon guidance | 0.169919 | 0.770 |
R-HSA-9675108 | Nervous system development | 0.210300 | 0.677 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.137945 | 0.860 |
R-HSA-6806834 | Signaling by MET | 0.157248 | 0.803 |
R-HSA-109581 | Apoptosis | 0.057535 | 1.240 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.207471 | 0.683 |
R-HSA-109582 | Hemostasis | 0.112730 | 0.948 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.037738 | 1.423 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.042441 | 1.372 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.111423 | 0.953 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.050776 | 1.294 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.137553 | 0.862 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.152756 | 0.816 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.154459 | 0.811 |
R-HSA-75153 | Apoptotic execution phase | 0.070230 | 1.153 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.046888 | 1.329 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.143405 | 0.843 |
R-HSA-9679506 | SARS-CoV Infections | 0.180473 | 0.744 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.220091 | 0.657 |
R-HSA-9839394 | TGFBR3 expression | 0.220091 | 0.657 |
R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.220091 | 0.657 |
R-HSA-3214842 | HDMs demethylate histones | 0.220091 | 0.657 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.220091 | 0.657 |
R-HSA-9620244 | Long-term potentiation | 0.220091 | 0.657 |
R-HSA-9614085 | FOXO-mediated transcription | 0.220496 | 0.657 |
R-HSA-3295583 | TRP channels | 0.226326 | 0.645 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.226326 | 0.645 |
R-HSA-9020702 | Interleukin-1 signaling | 0.226369 | 0.645 |
R-HSA-1640170 | Cell Cycle | 0.230640 | 0.637 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.232512 | 0.634 |
R-HSA-264876 | Insulin processing | 0.232512 | 0.634 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.236080 | 0.627 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.237556 | 0.624 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.238648 | 0.622 |
R-HSA-73614 | Pyrimidine salvage | 0.238648 | 0.622 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.244736 | 0.611 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.244736 | 0.611 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.244736 | 0.611 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.244736 | 0.611 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.248156 | 0.605 |
R-HSA-2672351 | Stimuli-sensing channels | 0.249957 | 0.602 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.249957 | 0.602 |
R-HSA-2424491 | DAP12 signaling | 0.250775 | 0.601 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.250775 | 0.601 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.252913 | 0.597 |
R-HSA-2129379 | Molecules associated with elastic fibres | 0.256767 | 0.590 |
R-HSA-186763 | Downstream signal transduction | 0.256767 | 0.590 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.262711 | 0.581 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.262711 | 0.581 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.264744 | 0.577 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.267702 | 0.572 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.268608 | 0.571 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.268608 | 0.571 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.268608 | 0.571 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.268608 | 0.571 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.268608 | 0.571 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.268608 | 0.571 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.268608 | 0.571 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.268608 | 0.571 |
R-HSA-354192 | Integrin signaling | 0.268608 | 0.571 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.268608 | 0.571 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.273619 | 0.563 |
R-HSA-390522 | Striated Muscle Contraction | 0.274458 | 0.562 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.274458 | 0.562 |
R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.274458 | 0.562 |
R-HSA-5223345 | Miscellaneous transport and binding events | 0.274458 | 0.562 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.280261 | 0.552 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.280261 | 0.552 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 0.280261 | 0.552 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.280261 | 0.552 |
R-HSA-5693538 | Homology Directed Repair | 0.285447 | 0.544 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.286019 | 0.544 |
R-HSA-187687 | Signalling to ERKs | 0.286019 | 0.544 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.286019 | 0.544 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.286019 | 0.544 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.286989 | 0.542 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.288401 | 0.540 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.288401 | 0.540 |
R-HSA-114604 | GPVI-mediated activation cascade | 0.291731 | 0.535 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.291731 | 0.535 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.297257 | 0.527 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.297257 | 0.527 |
R-HSA-1296072 | Voltage gated Potassium channels | 0.297397 | 0.527 |
R-HSA-110331 | Cleavage of the damaged purine | 0.297397 | 0.527 |
R-HSA-2132295 | MHC class II antigen presentation | 0.300205 | 0.523 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.303019 | 0.519 |
R-HSA-73927 | Depurination | 0.303019 | 0.519 |
R-HSA-1566948 | Elastic fibre formation | 0.303019 | 0.519 |
R-HSA-74217 | Purine salvage | 0.303019 | 0.519 |
R-HSA-8875878 | MET promotes cell motility | 0.303019 | 0.519 |
R-HSA-8964043 | Plasma lipoprotein clearance | 0.308595 | 0.511 |
R-HSA-69541 | Stabilization of p53 | 0.308595 | 0.511 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.308595 | 0.511 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.314128 | 0.503 |
R-HSA-451927 | Interleukin-2 family signaling | 0.314128 | 0.503 |
R-HSA-69481 | G2/M Checkpoints | 0.314915 | 0.502 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.319617 | 0.495 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.319617 | 0.495 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.319617 | 0.495 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.325062 | 0.488 |
R-HSA-6811438 | Intra-Golgi traffic | 0.325062 | 0.488 |
R-HSA-1474165 | Reproduction | 0.326636 | 0.486 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.330464 | 0.481 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.332805 | 0.478 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.335822 | 0.474 |
R-HSA-5654743 | Signaling by FGFR4 | 0.335822 | 0.474 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.335822 | 0.474 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.341139 | 0.467 |
R-HSA-69236 | G1 Phase | 0.341139 | 0.467 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.341139 | 0.467 |
R-HSA-2172127 | DAP12 interactions | 0.341139 | 0.467 |
R-HSA-190828 | Gap junction trafficking | 0.341139 | 0.467 |
R-HSA-375280 | Amine ligand-binding receptors | 0.341139 | 0.467 |
R-HSA-373752 | Netrin-1 signaling | 0.341139 | 0.467 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.346413 | 0.460 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.346413 | 0.460 |
R-HSA-5654741 | Signaling by FGFR3 | 0.346413 | 0.460 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.351645 | 0.454 |
R-HSA-9675135 | Diseases of DNA repair | 0.351645 | 0.454 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.351645 | 0.454 |
R-HSA-6807070 | PTEN Regulation | 0.355693 | 0.449 |
R-HSA-437239 | Recycling pathway of L1 | 0.356836 | 0.448 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.356836 | 0.448 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.361985 | 0.441 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.361985 | 0.441 |
R-HSA-425410 | Metal ion SLC transporters | 0.361985 | 0.441 |
R-HSA-9031628 | NGF-stimulated transcription | 0.361985 | 0.441 |
R-HSA-4839726 | Chromatin organization | 0.365527 | 0.437 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.367094 | 0.435 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.367196 | 0.435 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.368215 | 0.434 |
R-HSA-912446 | Meiotic recombination | 0.377189 | 0.423 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.377189 | 0.423 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.382177 | 0.418 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.382177 | 0.418 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.392034 | 0.407 |
R-HSA-446652 | Interleukin-1 family signaling | 0.395598 | 0.403 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.398407 | 0.400 |
R-HSA-5654736 | Signaling by FGFR1 | 0.401735 | 0.396 |
R-HSA-913531 | Interferon Signaling | 0.406237 | 0.391 |
R-HSA-5621480 | Dectin-2 family | 0.406527 | 0.391 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.406527 | 0.391 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.411282 | 0.386 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.415999 | 0.381 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.415999 | 0.381 |
R-HSA-9006936 | Signaling by TGFB family members | 0.417901 | 0.379 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.417901 | 0.379 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.420678 | 0.376 |
R-HSA-1227986 | Signaling by ERBB2 | 0.420678 | 0.376 |
R-HSA-450294 | MAP kinase activation | 0.425320 | 0.371 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.429925 | 0.367 |
R-HSA-186797 | Signaling by PDGF | 0.429925 | 0.367 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.429925 | 0.367 |
R-HSA-373755 | Semaphorin interactions | 0.434494 | 0.362 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.452407 | 0.344 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.452407 | 0.344 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.463505 | 0.334 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.465472 | 0.332 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.465472 | 0.332 |
R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.465472 | 0.332 |
R-HSA-448424 | Interleukin-17 signaling | 0.465472 | 0.332 |
R-HSA-195721 | Signaling by WNT | 0.469692 | 0.328 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.469758 | 0.328 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.474009 | 0.324 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.474009 | 0.324 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.474009 | 0.324 |
R-HSA-2559583 | Cellular Senescence | 0.474381 | 0.324 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.482411 | 0.317 |
R-HSA-983712 | Ion channel transport | 0.497572 | 0.303 |
R-HSA-4086400 | PCP/CE pathway | 0.498818 | 0.302 |
R-HSA-9955298 | SLC-mediated transport of organic anions | 0.498818 | 0.302 |
R-HSA-216083 | Integrin cell surface interactions | 0.498818 | 0.302 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.506827 | 0.295 |
R-HSA-9833482 | PKR-mediated signaling | 0.506827 | 0.295 |
R-HSA-5654738 | Signaling by FGFR2 | 0.506827 | 0.295 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.514709 | 0.288 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.517617 | 0.286 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.518603 | 0.285 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.518603 | 0.285 |
R-HSA-8957322 | Metabolism of steroids | 0.521905 | 0.282 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.522466 | 0.282 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.525024 | 0.280 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.526298 | 0.279 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.533871 | 0.273 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.533871 | 0.273 |
R-HSA-1474244 | Extracellular matrix organization | 0.535489 | 0.271 |
R-HSA-438064 | Post NMDA receptor activation events | 0.537612 | 0.270 |
R-HSA-202424 | Downstream TCR signaling | 0.548658 | 0.261 |
R-HSA-73884 | Base Excision Repair | 0.548658 | 0.261 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.552282 | 0.258 |
R-HSA-112316 | Neuronal System | 0.553040 | 0.257 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.556395 | 0.255 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.559442 | 0.252 |
R-HSA-1474290 | Collagen formation | 0.566489 | 0.247 |
R-HSA-1296071 | Potassium Channels | 0.576851 | 0.239 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.580249 | 0.236 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.583621 | 0.234 |
R-HSA-190236 | Signaling by FGFR | 0.583621 | 0.234 |
R-HSA-3214847 | HATs acetylate histones | 0.586966 | 0.231 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 0.586966 | 0.231 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.588054 | 0.231 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.592472 | 0.227 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.593576 | 0.227 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.596842 | 0.224 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.596842 | 0.224 |
R-HSA-1483255 | PI Metabolism | 0.596842 | 0.224 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.600081 | 0.222 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.603295 | 0.219 |
R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.606483 | 0.217 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.609646 | 0.215 |
R-HSA-15869 | Metabolism of nucleotides | 0.609790 | 0.215 |
R-HSA-8939211 | ESR-mediated signaling | 0.611915 | 0.213 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.612783 | 0.213 |
R-HSA-212436 | Generic Transcription Pathway | 0.614093 | 0.212 |
R-HSA-211000 | Gene Silencing by RNA | 0.615895 | 0.210 |
R-HSA-202403 | TCR signaling | 0.625084 | 0.204 |
R-HSA-194068 | Bile acid and bile salt metabolism | 0.625084 | 0.204 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.631089 | 0.200 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.634055 | 0.198 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.636998 | 0.196 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.639917 | 0.194 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.642813 | 0.192 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.645686 | 0.190 |
R-HSA-373760 | L1CAM interactions | 0.648536 | 0.188 |
R-HSA-2980736 | Peptide hormone metabolism | 0.651363 | 0.186 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.654167 | 0.184 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.667858 | 0.175 |
R-HSA-9711123 | Cellular response to chemical stress | 0.673498 | 0.172 |
R-HSA-194138 | Signaling by VEGF | 0.675813 | 0.170 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.684468 | 0.165 |
R-HSA-446728 | Cell junction organization | 0.691613 | 0.160 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.695667 | 0.158 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.698627 | 0.156 |
R-HSA-9824446 | Viral Infection Pathways | 0.707732 | 0.150 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.708155 | 0.150 |
R-HSA-5368287 | Mitochondrial translation | 0.712838 | 0.147 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.731108 | 0.136 |
R-HSA-69242 | S Phase | 0.737293 | 0.132 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.743596 | 0.129 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.749749 | 0.125 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.749749 | 0.125 |
R-HSA-1500931 | Cell-Cell communication | 0.753071 | 0.123 |
R-HSA-1643685 | Disease | 0.777991 | 0.109 |
R-HSA-418555 | G alpha (s) signalling events | 0.783708 | 0.106 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.785455 | 0.105 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.787187 | 0.104 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.787187 | 0.104 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.790610 | 0.102 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.790610 | 0.102 |
R-HSA-168255 | Influenza Infection | 0.797294 | 0.098 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.797662 | 0.098 |
R-HSA-5617833 | Cilium Assembly | 0.814601 | 0.089 |
R-HSA-5663205 | Infectious disease | 0.819506 | 0.086 |
R-HSA-382551 | Transport of small molecules | 0.819978 | 0.086 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.823415 | 0.084 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.829058 | 0.081 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.837084 | 0.077 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.846193 | 0.073 |
R-HSA-397014 | Muscle contraction | 0.846193 | 0.073 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.850825 | 0.070 |
R-HSA-68882 | Mitotic Anaphase | 0.851113 | 0.070 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.852319 | 0.069 |
R-HSA-418990 | Adherens junctions interactions | 0.853515 | 0.069 |
R-HSA-8951664 | Neddylation | 0.857045 | 0.067 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.867138 | 0.062 |
R-HSA-157118 | Signaling by NOTCH | 0.877524 | 0.057 |
R-HSA-388396 | GPCR downstream signalling | 0.884999 | 0.053 |
R-HSA-74160 | Gene expression (Transcription) | 0.886136 | 0.052 |
R-HSA-421270 | Cell-cell junction organization | 0.888020 | 0.052 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.892491 | 0.049 |
R-HSA-449147 | Signaling by Interleukins | 0.894199 | 0.049 |
R-HSA-416476 | G alpha (q) signalling events | 0.899279 | 0.046 |
R-HSA-1483257 | Phospholipid metabolism | 0.921797 | 0.035 |
R-HSA-372790 | Signaling by GPCR | 0.925624 | 0.034 |
R-HSA-597592 | Post-translational protein modification | 0.930446 | 0.031 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.936256 | 0.029 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.937802 | 0.028 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.937802 | 0.028 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.955553 | 0.020 |
R-HSA-8953897 | Cellular responses to stimuli | 0.960849 | 0.017 |
R-HSA-1266738 | Developmental Biology | 0.961133 | 0.017 |
R-HSA-68886 | M Phase | 0.961974 | 0.017 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.964394 | 0.016 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.965546 | 0.015 |
R-HSA-8978868 | Fatty acid metabolism | 0.969040 | 0.014 |
R-HSA-2262752 | Cellular responses to stress | 0.969955 | 0.013 |
R-HSA-72766 | Translation | 0.974171 | 0.011 |
R-HSA-392499 | Metabolism of proteins | 0.990639 | 0.004 |
R-HSA-500792 | GPCR ligand binding | 0.993137 | 0.003 |
R-HSA-556833 | Metabolism of lipids | 0.998498 | 0.001 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
P90RSK |
0.824 | 0.602 | -3 | 0.786 |
SRPK2 |
0.823 | 0.596 | -3 | 0.867 |
RSK2 |
0.823 | 0.563 | -3 | 0.790 |
MAPKAPK2 |
0.822 | 0.557 | -3 | 0.772 |
CDKL1 |
0.822 | 0.653 | -3 | 0.751 |
RSK3 |
0.821 | 0.566 | -3 | 0.779 |
MSK2 |
0.820 | 0.562 | -3 | 0.799 |
PRKD2 |
0.819 | 0.514 | -3 | 0.734 |
NUAK1 |
0.818 | 0.508 | -3 | 0.700 |
PRKD3 |
0.818 | 0.579 | -3 | 0.774 |
AKT2 |
0.818 | 0.604 | -3 | 0.845 |
CDKL5 |
0.818 | 0.545 | -3 | 0.768 |
MAPKAPK3 |
0.817 | 0.541 | -3 | 0.704 |
SRPK1 |
0.817 | 0.545 | -3 | 0.820 |
SIK |
0.816 | 0.524 | -3 | 0.713 |
PRKD1 |
0.816 | 0.425 | -3 | 0.657 |
MSK1 |
0.816 | 0.496 | -3 | 0.780 |
PIM3 |
0.816 | 0.502 | -3 | 0.685 |
NDR2 |
0.815 | 0.361 | -3 | 0.619 |
AMPKA2 |
0.815 | 0.483 | -3 | 0.658 |
NUAK2 |
0.815 | 0.500 | -3 | 0.667 |
RSK4 |
0.814 | 0.537 | -3 | 0.809 |
SRPK3 |
0.814 | 0.546 | -3 | 0.816 |
SBK |
0.814 | 0.678 | -3 | 0.889 |
PKN3 |
0.813 | 0.477 | -3 | 0.651 |
NDR1 |
0.811 | 0.403 | -3 | 0.644 |
AMPKA1 |
0.811 | 0.435 | -3 | 0.609 |
PKACA |
0.811 | 0.446 | -2 | 0.432 |
PIM1 |
0.811 | 0.546 | -3 | 0.756 |
PRKX |
0.810 | 0.457 | -3 | 0.789 |
MAPKAPK5 |
0.810 | 0.579 | -3 | 0.764 |
PKACB |
0.809 | 0.411 | -2 | 0.480 |
BRSK1 |
0.809 | 0.457 | -3 | 0.697 |
P70S6KB |
0.809 | 0.500 | -3 | 0.725 |
CAMK1B |
0.809 | 0.530 | -3 | 0.626 |
QSK |
0.809 | 0.409 | 4 | 0.875 |
AKT3 |
0.808 | 0.577 | -3 | 0.882 |
SGK1 |
0.808 | 0.622 | -3 | 0.883 |
CHK2 |
0.808 | 0.662 | -3 | 0.844 |
CAMK1D |
0.807 | 0.596 | -3 | 0.791 |
HIPK4 |
0.807 | 0.377 | 1 | 0.705 |
ICK |
0.807 | 0.489 | -3 | 0.700 |
CDC7 |
0.806 | 0.156 | 1 | 0.880 |
PKACG |
0.806 | 0.357 | -2 | 0.548 |
AKT1 |
0.806 | 0.526 | -3 | 0.813 |
SGK3 |
0.805 | 0.498 | -3 | 0.732 |
P70S6K |
0.805 | 0.548 | -3 | 0.799 |
CAMK2D |
0.805 | 0.353 | -3 | 0.596 |
LATS2 |
0.804 | 0.300 | -5 | 0.740 |
MELK |
0.804 | 0.473 | -3 | 0.665 |
CAMK4 |
0.803 | 0.389 | -3 | 0.621 |
CAMK1A |
0.803 | 0.598 | -3 | 0.820 |
MARK4 |
0.803 | 0.257 | 4 | 0.884 |
BRSK2 |
0.802 | 0.358 | -3 | 0.625 |
MYLK4 |
0.802 | 0.422 | -2 | 0.575 |
PIM2 |
0.801 | 0.545 | -3 | 0.791 |
RAF1 |
0.801 | 0.202 | 1 | 0.895 |
TSSK1 |
0.800 | 0.333 | -3 | 0.596 |
COT |
0.800 | 0.064 | 2 | 0.831 |
DYRK1A |
0.800 | 0.447 | 1 | 0.676 |
SKMLCK |
0.799 | 0.347 | -2 | 0.654 |
CLK4 |
0.799 | 0.454 | -3 | 0.775 |
PKN2 |
0.799 | 0.356 | -3 | 0.604 |
CAMK2B |
0.799 | 0.327 | 2 | 0.786 |
CLK1 |
0.799 | 0.457 | -3 | 0.774 |
DAPK2 |
0.798 | 0.466 | -3 | 0.599 |
CAMK1G |
0.798 | 0.522 | -3 | 0.756 |
QIK |
0.797 | 0.336 | -3 | 0.584 |
CAMLCK |
0.797 | 0.383 | -2 | 0.635 |
CAMK2A |
0.796 | 0.376 | 2 | 0.782 |
MOS |
0.796 | 0.173 | 1 | 0.875 |
PKN1 |
0.796 | 0.518 | -3 | 0.779 |
TGFBR2 |
0.796 | 0.109 | -2 | 0.651 |
IKKB |
0.796 | 0.059 | -2 | 0.617 |
PHKG1 |
0.796 | 0.352 | -3 | 0.637 |
PKG2 |
0.795 | 0.303 | -2 | 0.482 |
AURC |
0.795 | 0.190 | -2 | 0.473 |
TBK1 |
0.794 | 0.022 | 1 | 0.815 |
MARK2 |
0.793 | 0.279 | 4 | 0.824 |
DCAMKL1 |
0.792 | 0.482 | -3 | 0.697 |
CHK1 |
0.792 | 0.322 | -3 | 0.563 |
NIM1 |
0.792 | 0.253 | 3 | 0.823 |
TSSK2 |
0.792 | 0.250 | -5 | 0.836 |
MARK3 |
0.791 | 0.274 | 4 | 0.851 |
AURB |
0.791 | 0.198 | -2 | 0.468 |
MARK1 |
0.791 | 0.298 | 4 | 0.858 |
CLK2 |
0.791 | 0.439 | -3 | 0.800 |
CLK3 |
0.790 | 0.226 | 1 | 0.761 |
IKKE |
0.790 | 0.000 | 1 | 0.814 |
WNK1 |
0.790 | 0.191 | -2 | 0.662 |
NIK |
0.789 | 0.352 | -3 | 0.525 |
PKCD |
0.789 | 0.273 | 2 | 0.721 |
PRPK |
0.789 | -0.029 | -1 | 0.869 |
MTOR |
0.789 | -0.012 | 1 | 0.824 |
GCN2 |
0.788 | -0.057 | 2 | 0.754 |
PDHK4 |
0.788 | -0.085 | 1 | 0.872 |
AURA |
0.788 | 0.184 | -2 | 0.457 |
LATS1 |
0.788 | 0.317 | -3 | 0.594 |
PKG1 |
0.787 | 0.386 | -2 | 0.401 |
HIPK1 |
0.787 | 0.350 | 1 | 0.620 |
NLK |
0.787 | 0.097 | 1 | 0.790 |
GRK1 |
0.786 | 0.128 | -2 | 0.773 |
RIPK3 |
0.786 | 0.086 | 3 | 0.825 |
DYRK2 |
0.786 | 0.254 | 1 | 0.608 |
DSTYK |
0.786 | -0.040 | 2 | 0.821 |
PAK3 |
0.786 | 0.208 | -2 | 0.568 |
PAK1 |
0.785 | 0.226 | -2 | 0.575 |
SNRK |
0.785 | 0.279 | 2 | 0.646 |
PDHK1 |
0.785 | -0.082 | 1 | 0.869 |
HUNK |
0.785 | 0.075 | 2 | 0.742 |
BCKDK |
0.784 | -0.016 | -1 | 0.862 |
PAK6 |
0.784 | 0.154 | -2 | 0.495 |
RIPK1 |
0.784 | 0.188 | 1 | 0.806 |
MST4 |
0.784 | 0.114 | 2 | 0.767 |
DAPK3 |
0.784 | 0.461 | -3 | 0.717 |
ATR |
0.783 | 0.037 | 1 | 0.786 |
DYRK3 |
0.783 | 0.389 | 1 | 0.623 |
WNK3 |
0.783 | 0.095 | 1 | 0.834 |
SMMLCK |
0.783 | 0.447 | -3 | 0.684 |
HIPK3 |
0.783 | 0.339 | 1 | 0.651 |
CAMK2G |
0.783 | 0.004 | 2 | 0.794 |
HIPK2 |
0.783 | 0.286 | 1 | 0.517 |
BMPR2 |
0.783 | -0.081 | -2 | 0.698 |
DCAMKL2 |
0.782 | 0.377 | -3 | 0.672 |
DAPK1 |
0.782 | 0.460 | -3 | 0.745 |
CRIK |
0.782 | 0.547 | -3 | 0.832 |
MAK |
0.782 | 0.413 | -2 | 0.555 |
MNK2 |
0.782 | 0.160 | -2 | 0.566 |
MASTL |
0.781 | 0.043 | -2 | 0.640 |
PAK2 |
0.780 | 0.207 | -2 | 0.567 |
MRCKB |
0.780 | 0.460 | -3 | 0.754 |
IKKA |
0.780 | -0.037 | -2 | 0.622 |
PHKG2 |
0.780 | 0.312 | -3 | 0.643 |
KIS |
0.779 | 0.047 | 1 | 0.623 |
GRK4 |
0.779 | 0.014 | -2 | 0.743 |
ERK5 |
0.779 | -0.004 | 1 | 0.744 |
PKCB |
0.778 | 0.237 | 2 | 0.656 |
ULK2 |
0.777 | -0.134 | 2 | 0.742 |
NEK7 |
0.777 | -0.101 | -3 | 0.365 |
PAK5 |
0.777 | 0.199 | -2 | 0.452 |
BMPR1B |
0.777 | 0.082 | 1 | 0.847 |
GRK5 |
0.777 | -0.054 | -3 | 0.381 |
MRCKA |
0.776 | 0.432 | -3 | 0.731 |
CK1E |
0.776 | 0.032 | -3 | 0.259 |
ATM |
0.776 | 0.042 | 1 | 0.737 |
MNK1 |
0.776 | 0.174 | -2 | 0.587 |
PKCG |
0.775 | 0.199 | 2 | 0.648 |
GRK6 |
0.775 | 0.017 | 1 | 0.877 |
SSTK |
0.774 | 0.203 | 4 | 0.857 |
DLK |
0.774 | 0.095 | 1 | 0.869 |
DYRK1B |
0.774 | 0.255 | 1 | 0.558 |
PKCT |
0.774 | 0.290 | 2 | 0.660 |
ALK4 |
0.774 | 0.026 | -2 | 0.694 |
TGFBR1 |
0.774 | 0.021 | -2 | 0.683 |
ANKRD3 |
0.773 | 0.053 | 1 | 0.863 |
PKCH |
0.773 | 0.231 | 2 | 0.643 |
MOK |
0.773 | 0.429 | 1 | 0.610 |
PAK4 |
0.773 | 0.183 | -2 | 0.457 |
DMPK1 |
0.772 | 0.459 | -3 | 0.745 |
PASK |
0.772 | 0.379 | -3 | 0.638 |
CDK7 |
0.771 | 0.034 | 1 | 0.604 |
PKCA |
0.771 | 0.166 | 2 | 0.647 |
NEK6 |
0.771 | -0.123 | -2 | 0.657 |
ULK1 |
0.771 | -0.147 | -3 | 0.322 |
DYRK4 |
0.770 | 0.210 | 1 | 0.540 |
DNAPK |
0.770 | 0.029 | 1 | 0.719 |
MLK1 |
0.770 | -0.080 | 2 | 0.737 |
TTBK2 |
0.769 | -0.005 | 2 | 0.633 |
ALK2 |
0.769 | 0.049 | -2 | 0.699 |
NEK9 |
0.768 | -0.119 | 2 | 0.772 |
CK1D |
0.768 | 0.024 | -3 | 0.230 |
ROCK2 |
0.768 | 0.418 | -3 | 0.700 |
ACVR2A |
0.768 | -0.005 | -2 | 0.638 |
IRE1 |
0.767 | 0.027 | 1 | 0.739 |
FAM20C |
0.767 | 0.034 | 2 | 0.624 |
ACVR2B |
0.767 | -0.004 | -2 | 0.655 |
PKCZ |
0.766 | 0.148 | 2 | 0.710 |
WNK4 |
0.766 | 0.167 | -2 | 0.645 |
GRK2 |
0.766 | 0.031 | -2 | 0.654 |
MEK1 |
0.766 | 0.005 | 2 | 0.798 |
GRK7 |
0.766 | 0.085 | 1 | 0.808 |
MLK2 |
0.765 | -0.098 | 2 | 0.769 |
BRAF |
0.765 | 0.086 | -4 | 0.765 |
PLK1 |
0.765 | -0.039 | -2 | 0.630 |
DRAK1 |
0.764 | 0.121 | 1 | 0.831 |
CHAK2 |
0.764 | -0.074 | -1 | 0.823 |
PKCE |
0.763 | 0.298 | 2 | 0.627 |
YSK4 |
0.763 | -0.056 | 1 | 0.843 |
IRE2 |
0.762 | 0.001 | 2 | 0.697 |
ROCK1 |
0.762 | 0.426 | -3 | 0.729 |
PLK4 |
0.761 | -0.007 | 2 | 0.597 |
CK1A2 |
0.761 | -0.002 | -3 | 0.251 |
PKCI |
0.760 | 0.198 | 2 | 0.662 |
CK1G1 |
0.760 | -0.029 | -3 | 0.245 |
CDK8 |
0.760 | -0.050 | 1 | 0.590 |
BMPR1A |
0.760 | 0.037 | 1 | 0.841 |
PDK1 |
0.759 | 0.311 | 1 | 0.836 |
NEK2 |
0.758 | -0.093 | 2 | 0.743 |
GRK3 |
0.757 | 0.027 | -2 | 0.648 |
CDK19 |
0.757 | -0.040 | 1 | 0.545 |
VRK2 |
0.756 | -0.100 | 1 | 0.835 |
CDK14 |
0.756 | 0.093 | 1 | 0.565 |
PKR |
0.755 | -0.002 | 1 | 0.801 |
CDK18 |
0.755 | 0.007 | 1 | 0.515 |
MEK5 |
0.755 | 0.020 | 2 | 0.774 |
MEKK3 |
0.755 | 0.014 | 1 | 0.845 |
PLK3 |
0.755 | -0.087 | 2 | 0.736 |
MLK3 |
0.754 | -0.080 | 2 | 0.658 |
IRAK1 |
0.754 | 0.007 | -1 | 0.797 |
ZAK |
0.754 | -0.035 | 1 | 0.836 |
MPSK1 |
0.754 | 0.054 | 1 | 0.700 |
SMG1 |
0.753 | -0.084 | 1 | 0.720 |
TLK1 |
0.753 | -0.019 | -2 | 0.692 |
TLK2 |
0.753 | -0.091 | 1 | 0.786 |
HRI |
0.753 | -0.075 | -2 | 0.656 |
MEKK1 |
0.752 | -0.068 | 1 | 0.824 |
MLK4 |
0.752 | -0.086 | 2 | 0.653 |
MST3 |
0.752 | 0.056 | 2 | 0.740 |
PERK |
0.751 | -0.061 | -2 | 0.674 |
TAO3 |
0.751 | 0.056 | 1 | 0.842 |
P38A |
0.751 | -0.017 | 1 | 0.633 |
CHAK1 |
0.751 | -0.065 | 2 | 0.730 |
IRAK4 |
0.751 | 0.012 | 1 | 0.754 |
CDK13 |
0.750 | -0.035 | 1 | 0.575 |
CDK9 |
0.750 | -0.007 | 1 | 0.584 |
JNK2 |
0.750 | -0.005 | 1 | 0.564 |
CDK10 |
0.749 | 0.112 | 1 | 0.544 |
MEKK2 |
0.749 | -0.021 | 2 | 0.752 |
CDK12 |
0.748 | -0.004 | 1 | 0.552 |
NEK11 |
0.748 | 0.010 | 1 | 0.852 |
CDK17 |
0.748 | -0.010 | 1 | 0.474 |
PRP4 |
0.748 | -0.068 | -3 | 0.296 |
P38B |
0.747 | -0.024 | 1 | 0.561 |
RIPK2 |
0.747 | 0.040 | 1 | 0.816 |
JNK3 |
0.747 | -0.025 | 1 | 0.592 |
MEKK6 |
0.746 | 0.062 | 1 | 0.822 |
TTBK1 |
0.746 | -0.057 | 2 | 0.557 |
NEK5 |
0.746 | -0.097 | 1 | 0.807 |
HPK1 |
0.746 | 0.126 | 1 | 0.842 |
TAK1 |
0.746 | 0.099 | 1 | 0.875 |
ERK2 |
0.745 | -0.028 | 1 | 0.595 |
CDK5 |
0.745 | -0.028 | 1 | 0.612 |
ERK1 |
0.745 | -0.030 | 1 | 0.554 |
NEK8 |
0.745 | 0.036 | 2 | 0.746 |
GCK |
0.744 | 0.079 | 1 | 0.854 |
LKB1 |
0.744 | -0.051 | -3 | 0.364 |
MAP3K15 |
0.743 | 0.025 | 1 | 0.830 |
TAO2 |
0.743 | 0.017 | 2 | 0.782 |
P38G |
0.741 | -0.022 | 1 | 0.476 |
NEK4 |
0.741 | -0.039 | 1 | 0.802 |
GAK |
0.740 | 0.037 | 1 | 0.778 |
CAMKK2 |
0.740 | -0.088 | -2 | 0.581 |
PINK1 |
0.740 | -0.153 | 1 | 0.733 |
MINK |
0.739 | 0.019 | 1 | 0.835 |
CDK1 |
0.739 | -0.039 | 1 | 0.557 |
CAMKK1 |
0.739 | -0.142 | -2 | 0.599 |
KHS1 |
0.739 | 0.094 | 1 | 0.827 |
CDK2 |
0.738 | -0.062 | 1 | 0.652 |
CDK16 |
0.738 | -0.015 | 1 | 0.485 |
MST2 |
0.738 | -0.066 | 1 | 0.854 |
KHS2 |
0.738 | 0.116 | 1 | 0.838 |
LOK |
0.737 | 0.052 | -2 | 0.572 |
PBK |
0.737 | 0.058 | 1 | 0.693 |
GSK3B |
0.737 | -0.018 | 4 | 0.364 |
HGK |
0.737 | -0.012 | 3 | 0.843 |
LRRK2 |
0.735 | 0.072 | 2 | 0.777 |
TNIK |
0.734 | 0.011 | 3 | 0.829 |
NEK1 |
0.734 | -0.058 | 1 | 0.802 |
SLK |
0.732 | 0.005 | -2 | 0.558 |
CK1A |
0.732 | -0.014 | -3 | 0.185 |
PLK2 |
0.732 | -0.076 | -3 | 0.280 |
MEK2 |
0.732 | -0.110 | 2 | 0.775 |
BUB1 |
0.731 | 0.070 | -5 | 0.755 |
CK2A2 |
0.731 | -0.019 | 1 | 0.749 |
NEK3 |
0.731 | -0.047 | 1 | 0.785 |
MST1 |
0.730 | -0.055 | 1 | 0.835 |
CDK4 |
0.730 | 0.031 | 1 | 0.531 |
YSK1 |
0.729 | -0.012 | 2 | 0.731 |
VRK1 |
0.729 | -0.038 | 2 | 0.784 |
EEF2K |
0.727 | -0.061 | 3 | 0.789 |
P38D |
0.727 | -0.049 | 1 | 0.469 |
ERK7 |
0.726 | -0.042 | 2 | 0.461 |
GSK3A |
0.725 | -0.032 | 4 | 0.369 |
CDK3 |
0.725 | -0.036 | 1 | 0.490 |
HASPIN |
0.725 | 0.076 | -1 | 0.691 |
TTK |
0.724 | 0.017 | -2 | 0.659 |
CK2A1 |
0.721 | -0.029 | 1 | 0.733 |
STK33 |
0.720 | -0.071 | 2 | 0.556 |
JNK1 |
0.720 | -0.043 | 1 | 0.545 |
YANK3 |
0.720 | 0.005 | 2 | 0.353 |
TAO1 |
0.719 | 0.015 | 1 | 0.788 |
CDK6 |
0.719 | -0.034 | 1 | 0.544 |
ASK1 |
0.718 | -0.039 | 1 | 0.822 |
PDHK3_TYR |
0.715 | 0.016 | 4 | 0.843 |
ALPHAK3 |
0.715 | 0.002 | -1 | 0.767 |
OSR1 |
0.712 | -0.082 | 2 | 0.745 |
MAP2K4_TYR |
0.711 | 0.058 | -1 | 0.882 |
TESK1_TYR |
0.710 | 0.030 | 3 | 0.875 |
BIKE |
0.710 | -0.034 | 1 | 0.619 |
MYO3B |
0.708 | -0.055 | 2 | 0.752 |
PKMYT1_TYR |
0.708 | 0.013 | 3 | 0.874 |
MYO3A |
0.707 | -0.048 | 1 | 0.784 |
MAP2K7_TYR |
0.707 | -0.045 | 2 | 0.815 |
PINK1_TYR |
0.706 | 0.093 | 1 | 0.842 |
CK1G3 |
0.706 | -0.041 | -3 | 0.165 |
PDHK4_TYR |
0.706 | -0.037 | 2 | 0.848 |
ROS1 |
0.706 | 0.025 | 3 | 0.842 |
MAP2K6_TYR |
0.706 | -0.014 | -1 | 0.886 |
STLK3 |
0.705 | -0.098 | 1 | 0.808 |
RET |
0.705 | -0.001 | 1 | 0.828 |
LIMK2_TYR |
0.705 | 0.052 | -3 | 0.448 |
BMPR2_TYR |
0.704 | -0.006 | -1 | 0.859 |
MST1R |
0.704 | 0.017 | 3 | 0.859 |
PDHK1_TYR |
0.703 | -0.048 | -1 | 0.868 |
EPHA6 |
0.703 | 0.015 | -1 | 0.826 |
INSRR |
0.702 | 0.035 | 3 | 0.823 |
TYK2 |
0.702 | -0.058 | 1 | 0.825 |
CSF1R |
0.701 | -0.024 | 3 | 0.861 |
TYRO3 |
0.701 | -0.039 | 3 | 0.846 |
DDR1 |
0.701 | 0.026 | 4 | 0.785 |
JAK2 |
0.701 | -0.069 | 1 | 0.829 |
EPHB4 |
0.700 | -0.027 | -1 | 0.813 |
JAK3 |
0.700 | -0.012 | 1 | 0.829 |
LIMK1_TYR |
0.699 | -0.032 | 2 | 0.805 |
TXK |
0.698 | 0.005 | 1 | 0.860 |
NEK10_TYR |
0.698 | 0.046 | 1 | 0.749 |
TNK2 |
0.698 | 0.050 | 3 | 0.830 |
JAK1 |
0.697 | 0.003 | 1 | 0.807 |
FER |
0.697 | -0.051 | 1 | 0.874 |
FGR |
0.697 | -0.035 | 1 | 0.830 |
ABL2 |
0.697 | -0.029 | -1 | 0.806 |
AXL |
0.696 | 0.002 | 3 | 0.854 |
SRMS |
0.695 | -0.037 | 1 | 0.878 |
PDGFRB |
0.695 | -0.013 | 3 | 0.865 |
EPHB1 |
0.694 | -0.057 | 1 | 0.885 |
TNK1 |
0.694 | 0.032 | 3 | 0.832 |
FGFR2 |
0.693 | -0.025 | 3 | 0.860 |
ABL1 |
0.693 | -0.047 | -1 | 0.801 |
FGFR1 |
0.693 | -0.035 | 3 | 0.841 |
AAK1 |
0.692 | -0.020 | 1 | 0.498 |
EPHB3 |
0.692 | -0.052 | -1 | 0.800 |
KDR |
0.692 | 0.006 | 3 | 0.843 |
MERTK |
0.692 | -0.040 | 3 | 0.849 |
TEK |
0.692 | -0.037 | 3 | 0.811 |
ITK |
0.692 | -0.042 | -1 | 0.810 |
EPHB2 |
0.692 | -0.046 | -1 | 0.789 |
HCK |
0.692 | -0.064 | -1 | 0.807 |
YES1 |
0.692 | -0.058 | -1 | 0.810 |
KIT |
0.691 | -0.057 | 3 | 0.860 |
LCK |
0.691 | -0.022 | -1 | 0.804 |
EPHA4 |
0.691 | -0.045 | 2 | 0.724 |
FLT3 |
0.691 | -0.018 | 3 | 0.850 |
DDR2 |
0.690 | 0.081 | 3 | 0.818 |
TNNI3K_TYR |
0.690 | -0.017 | 1 | 0.780 |
MET |
0.689 | -0.006 | 3 | 0.846 |
ALK |
0.689 | -0.013 | 3 | 0.804 |
CK1G2 |
0.689 | -0.012 | -3 | 0.203 |
BLK |
0.688 | -0.005 | -1 | 0.788 |
TEC |
0.688 | -0.033 | -1 | 0.732 |
PDGFRA |
0.688 | -0.052 | 3 | 0.860 |
BTK |
0.686 | -0.091 | -1 | 0.787 |
BMX |
0.686 | -0.030 | -1 | 0.712 |
EPHA1 |
0.686 | -0.019 | 3 | 0.836 |
NTRK1 |
0.686 | -0.084 | -1 | 0.838 |
NTRK2 |
0.686 | -0.075 | 3 | 0.841 |
YANK2 |
0.685 | -0.049 | 2 | 0.372 |
LTK |
0.685 | -0.024 | 3 | 0.820 |
EPHA7 |
0.685 | -0.041 | 2 | 0.725 |
ERBB2 |
0.683 | -0.058 | 1 | 0.807 |
FGFR3 |
0.683 | -0.040 | 3 | 0.835 |
NTRK3 |
0.682 | -0.068 | -1 | 0.793 |
PTK2B |
0.682 | -0.016 | -1 | 0.770 |
FRK |
0.682 | -0.052 | -1 | 0.801 |
INSR |
0.682 | -0.062 | 3 | 0.790 |
FYN |
0.682 | -0.024 | -1 | 0.775 |
EPHA3 |
0.681 | -0.069 | 2 | 0.702 |
FLT4 |
0.680 | -0.054 | 3 | 0.831 |
FLT1 |
0.680 | -0.059 | -1 | 0.819 |
EPHA5 |
0.679 | -0.037 | 2 | 0.719 |
LYN |
0.679 | -0.076 | 3 | 0.795 |
PTK6 |
0.676 | -0.122 | -1 | 0.770 |
WEE1_TYR |
0.676 | -0.062 | -1 | 0.783 |
EPHA8 |
0.674 | -0.056 | -1 | 0.769 |
SYK |
0.672 | 0.018 | -1 | 0.749 |
SRC |
0.672 | -0.061 | -1 | 0.767 |
MATK |
0.671 | -0.071 | -1 | 0.727 |
CSK |
0.671 | -0.092 | 2 | 0.731 |
PTK2 |
0.670 | 0.001 | -1 | 0.756 |
EGFR |
0.669 | -0.073 | 1 | 0.723 |
IGF1R |
0.669 | -0.064 | 3 | 0.742 |
FGFR4 |
0.668 | -0.078 | -1 | 0.760 |
EPHA2 |
0.665 | -0.070 | -1 | 0.746 |
ERBB4 |
0.662 | -0.036 | 1 | 0.714 |
MUSK |
0.661 | -0.094 | 1 | 0.703 |
FES |
0.656 | -0.080 | -1 | 0.702 |
ZAP70 |
0.652 | -0.007 | -1 | 0.693 |