Motif 343 (n=116)

Position-wise Probabilities

Download
uniprot genes site source protein function
B9A064 IGLL5 S194 ochoa Immunoglobulin lambda-like polypeptide 5 (G lambda-1) (Germline immunoglobulin lambda 1) None
E9PAV3 NACA S738 ochoa Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.
O00220 TNFRSF10A S424 ochoa Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9430227}.
O14490 DLGAP1 S493 ochoa|psp Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) Part of the postsynaptic scaffold in neuronal cells.
O14639 ABLIM1 S631 ochoa Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}.
O15344 MID1 S311 ochoa E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.
O15360 FANCA S347 psp Fanconi anemia group A protein (Protein FACA) DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
O43318 MAP3K7 S375 ochoa Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}.
O60658 PDE8A S359 psp High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). {ECO:0000269|PubMed:18983167, ECO:0000269|PubMed:23509299}.
O94875 SORBS2 S843 ochoa Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}.
O95721 SNAP29 S78 ochoa Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}.
P04049 RAF1 S621 ochoa|psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P04183 TK1 S63 ochoa Thymidine kinase, cytosolic (EC 2.7.1.21) Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). {ECO:0000269|PubMed:22385435, ECO:0000269|PubMed:9575153, ECO:0000305|PubMed:17407781}.
P0CF74 IGLC6 S86 ochoa Immunoglobulin lambda constant 6 (Ig lambda-6 chain C region) Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0CG04 IGLC1 S86 ochoa Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region) Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DOY2 IGLC2 S86 ochoa Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region) Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P0DOY3 IGLC3 S86 ochoa Immunoglobulin lambda constant 3 (Ig lambda chain C region DOT) (Ig lambda chain C region NEWM) (Ig lambda-3 chain C regions) Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P10398 ARAF S582 ochoa|psp Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}.
P15056 BRAF S729 ochoa|psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P22459 KCNA4 T601 psp Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4) Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). {ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:27582084, ECO:0000269|PubMed:8495559}.
P26045 PTPN3 S835 psp Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
P32942 ICAM3 S518 ochoa|psp Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50) ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000269|PubMed:1448173, ECO:0000269|PubMed:23775590}.
P35367 HRH1 S398 psp Histamine H1 receptor (H1-R) (H1R) (HH1R) G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}.
P35612 ADD2 S532 ochoa Beta-adducin (Erythrocyte adducin subunit beta) Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}.
P38398 BRCA1 S1101 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P43405 SYK S178 psp Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}.
P46527 CDKN1B S140 ochoa|psp Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}.
P49327 FASN S1727 ochoa Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
P52179 MYOM1 S1399 ochoa Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P55198 MLLT6 S279 ochoa Protein AF-17 (ALL1-fused gene from chromosome 17 protein) None
P57075 UBASH3A S384 ochoa Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318, ECO:0000269|PubMed:18189269}.
Q00610 CLTC S1229 ochoa Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q00872 MYBPC1 S906 ochoa Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}.
Q01432 AMPD3 S85 ochoa AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) AMP deaminase plays a critical role in energy metabolism. {ECO:0000305|PubMed:9291127}.
Q12879 GRIN2A S1291 psp Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:20890276, ECO:0000269|PubMed:23933818, ECO:0000269|PubMed:23933819, ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:24504326, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27288002, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28182669, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:29644724, ECO:0000269|PubMed:36117210, ECO:0000269|PubMed:38307912, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}.
Q12933 TRAF2 S55 psp TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:10346818, PubMed:11784851, PubMed:12917689, PubMed:15383523, PubMed:18981220, PubMed:19150425, PubMed:19810754, PubMed:19918265, PubMed:19937093, PubMed:20047764, PubMed:20064526, PubMed:20385093, PubMed:20577214, PubMed:22212761). Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1 (PubMed:23453969, PubMed:28489822). Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases (PubMed:15383523, PubMed:18981220). Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain (PubMed:11907583, PubMed:19506082). Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR (PubMed:15121867). In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE (PubMed:23453969). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex (PubMed:28489822). Required for normal antibody isotype switching from IgM to IgG (By similarity). {ECO:0000250|UniProtKB:P39429, ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, ECO:0000269|PubMed:19150425, ECO:0000269|PubMed:19506082, ECO:0000269|PubMed:19810754, ECO:0000269|PubMed:19918265, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20047764, ECO:0000269|PubMed:20064526, ECO:0000269|PubMed:20385093, ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:22212761, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:28489822}.
Q13009 TIAM1 S172 ochoa|psp Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}.
Q13023 AKAP6 S1655 ochoa A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
Q13796 SHROOM2 S897 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q14451 GRB7 S368 ochoa Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}.
Q14766 LTBP1 S536 ochoa Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}.
Q2M1Z3 ARHGAP31 S272 ochoa Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}.
Q2PPJ7 RALGAPA2 S766 ochoa Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q49A26 GLYR1 S114 ochoa Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}.
Q53QZ3 ARHGAP15 S212 ochoa Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}.
Q5BKX6 SLC45A4 S456 ochoa Solute carrier family 45 member 4 Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}.
Q5JRC9 FAM47A S542 ochoa Protein FAM47A None
Q5T1Q4 SLC35F1 S374 ochoa Solute carrier family 35 member F1 Putative solute transporter. {ECO:0000305}.
Q5T5Y3 CAMSAP1 S827 ochoa Calmodulin-regulated spectrin-associated protein 1 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5VWN6 TASOR2 S221 ochoa Protein TASOR 2 None
Q6AI14 SLC9A4 S660 ochoa Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity). {ECO:0000250|UniProtKB:P26434, ECO:0000250|UniProtKB:Q8BUE1}.
Q6NYC1 JMJD6 S381 ochoa Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}.
Q6P995 FAM171B S405 ochoa Protein FAM171B None
Q6ZQN7 SLCO4C1 S79 ochoa Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}.
Q70EL2 USP45 S599 ochoa Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45) Catalyzes the deubiquitination of SPDL1 (PubMed:30258100). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (PubMed:30258100). {ECO:0000250|UniProtKB:E9QG68, ECO:0000269|PubMed:25538220, ECO:0000269|PubMed:30258100, ECO:0000269|PubMed:30573563}.
Q7Z7E8 UBE2Q1 S268 ochoa Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1) Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). {ECO:0000250|UniProtKB:Q7TSS2, ECO:0000269|PubMed:22496338}.
Q8IVL0 NAV3 S275 ochoa Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}.
Q8IVL0 NAV3 S1448 ochoa Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}.
Q8IVL1 NAV2 S1538 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IX21 SLF2 S653 ochoa SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.
Q8IXI1 RHOT2 S156 psp Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}.
Q8IZ21 PHACTR4 S443 ochoa Phosphatase and actin regulator 4 Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Q8IZW8 TNS4 S198 ochoa Tensin-4 (C-terminal tensin-like protein) Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}.
Q8N1W1 ARHGEF28 S624 ochoa Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.
Q8N1W1 ARHGEF28 S1538 ochoa Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.
Q8N4Y2 CRACR2B S307 ochoa EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}.
Q8NBA8 DTWD2 S132 ochoa tRNA-uridine aminocarboxypropyltransferase 2 (EC 2.5.1.25) (DTW domain-containing protein 2) Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502, PubMed:39173631). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). Involved in glycoRNA biosynthesis by mediating formation of acp3U, which acts as an attachment site for N-glycans on tRNAs (PubMed:39173631). GlycoRNAs consist of RNAs modified with secretory N-glycans that are presented on the cell surface (PubMed:39173631). {ECO:0000269|PubMed:31804502, ECO:0000269|PubMed:39173631}.
Q8NCN4 RNF169 S292 ochoa E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}.
Q8NDX5 PHC3 S228 ochoa Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}.
Q8NEY1 NAV1 S1048 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NF91 SYNE1 S5919 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8TE67 EPS8L3 S420 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) None
Q96A65 EXOC4 S410 ochoa Exocyst complex component 4 (Exocyst complex component Sec8) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}.
Q96B18 DACT3 S426 ochoa Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}.
Q96LR2 LURAP1 S126 ochoa Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A) Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250|UniProtKB:D4A8G3, ECO:0000269|PubMed:21048106}.
Q96MK2 RIPOR3 S397 ochoa RIPOR family member 3 None
Q96P20 NLRP3 S295 psp NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}.
Q96T37 RBM15 S873 ochoa RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
Q99704 DOK1 S460 ochoa Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.
Q99963 SH3GL3 S265 ochoa Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.
Q9BRR9 ARHGAP9 S144 ochoa Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}.
Q9BVI0 PHF20 S265 ochoa|psp PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}.
Q9BZ95 NSD3 S424 ochoa Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.
Q9BZF3 OSBPL6 S195 ochoa Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}.
Q9GZY8 MFF S179 ochoa Mitochondrial fission factor Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}.
Q9H2G2 SLK S1094 ochoa STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.
Q9H582 ZNF644 S199 ochoa Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) May be involved in transcriptional regulation.
Q9H5P4 PDZD7 S436 ochoa PDZ domain-containing protein 7 In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. {ECO:0000250|UniProtKB:E9Q9W7}.
Q9H792 PEAK1 S1250 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9H7D0 DOCK5 S1656 ochoa Dedicator of cytokinesis protein 5 Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}.
Q9H7U1 CCSER2 S223 ochoa Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}.
Q9HAW4 CLSPN S723 ochoa Claspin (hClaspin) Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.
Q9HB21 PLEKHA1 S299 ochoa Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}.
Q9NQC3 RTN4 S993 ochoa Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}.
Q9NQG6 MIEF1 S94 ochoa Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33632269}.
Q9NR09 BIRC6 S3742 ochoa Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}.
Q9NV58 RNF19A S284 ochoa E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}.
Q9NY74 ETAA1 S344 ochoa Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}.
Q9NYL2 MAP3K20 S567 ochoa Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.
Q9NZN5 ARHGEF12 S41 ochoa Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.
Q9P212 PLCE1 S67 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}.
Q9P266 JCAD S757 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9P270 SLAIN2 S435 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9P273 TENM3 S111 ochoa Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}.
Q9UBP0 SPAST S597 ochoa Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}.
Q9UH92 MLX S74 ochoa Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Q9UHQ4 BCAP29 S74 ochoa B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29) May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity). {ECO:0000250}.
Q9UKV8 AGO2 S387 ochoa|psp Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}.
Q9ULV3 CIZ1 S868 ochoa Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) May regulate the subcellular localization of CIP/WAF1.
Q9UPQ0 LIMCH1 S493 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UQB8 BAIAP2 S338 ochoa BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.
Q9Y5X3 SNX5 S22 ochoa Sorting nexin-5 Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}.
Q9Y620 RAD54B S64 Sugiyama DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B) Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. {ECO:0000269|PubMed:11782437, ECO:0000269|PubMed:11884632}.
P11717 IGF2R S1378 Sugiyama Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}.
Q6UXD5 SEZ6L2 S719 Sugiyama Seizure 6-like protein 2 May contribute to specialized endoplasmic reticulum functions in neurons. {ECO:0000250}.
Q8NB16 MLKL S360 SIGNOR Mixed lineage kinase domain-like protein (hMLKL) Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}.
Download
reactome_id name p -log10_p
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.000079 4.103
R-HSA-9660537 Signaling by MRAS-complex mutants 0.000104 3.981
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.000104 3.981
R-HSA-163765 ChREBP activates metabolic gene expression 0.000212 3.674
R-HSA-5675221 Negative regulation of MAPK pathway 0.000697 3.157
R-HSA-2029481 FCGR activation 0.001529 2.816
R-HSA-9664407 Parasite infection 0.001761 2.754
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.001761 2.754
R-HSA-9664417 Leishmania phagocytosis 0.001761 2.754
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.001818 2.740
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.001529 2.816
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.001804 2.744
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.001954 2.709
R-HSA-5218900 CASP8 activity is inhibited 0.004305 2.366
R-HSA-9700645 ALK mutants bind TKIs 0.004305 2.366
R-HSA-3371378 Regulation by c-FLIP 0.003637 2.439
R-HSA-5690714 CD22 mediated BCR regulation 0.002824 2.549
R-HSA-69416 Dimerization of procaspase-8 0.003637 2.439
R-HSA-5673000 RAF activation 0.004543 2.343
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.004821 2.317
R-HSA-5675482 Regulation of necroptotic cell death 0.003956 2.403
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.004098 2.387
R-HSA-2029485 Role of phospholipids in phagocytosis 0.003999 2.398
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.003093 2.510
R-HSA-73887 Death Receptor Signaling 0.002764 2.558
R-HSA-9658195 Leishmania infection 0.003079 2.512
R-HSA-9824443 Parasitic Infection Pathways 0.003079 2.512
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.003637 2.439
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.003999 2.398
R-HSA-2871796 FCERI mediated MAPK activation 0.003387 2.470
R-HSA-202733 Cell surface interactions at the vascular wall 0.004865 2.313
R-HSA-9693928 Defective RIPK1-mediated regulated necrosis 0.005027 2.299
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.005518 2.258
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.005785 2.238
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.005869 2.231
R-HSA-8953750 Transcriptional Regulation by E2F6 0.006233 2.205
R-HSA-9656223 Signaling by RAF1 mutants 0.007405 2.130
R-HSA-5674135 MAP2K and MAPK activation 0.007405 2.130
R-HSA-9607240 FLT3 Signaling 0.007001 2.155
R-HSA-173623 Classical antibody-mediated complement activation 0.007988 2.098
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.009629 2.016
R-HSA-9649948 Signaling downstream of RAS mutants 0.009629 2.016
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.009629 2.016
R-HSA-6802949 Signaling by RAS mutants 0.009629 2.016
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.009389 2.027
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.009274 2.033
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 0.008419 2.075
R-HSA-2871837 FCERI mediated NF-kB activation 0.010153 1.993
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 0.011472 1.940
R-HSA-168249 Innate Immune System 0.011412 1.943
R-HSA-2168880 Scavenging of heme from plasma 0.010785 1.967
R-HSA-9679191 Potential therapeutics for SARS 0.011730 1.931
R-HSA-6794361 Neurexins and neuroligins 0.012761 1.894
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.013333 1.875
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 0.015895 1.799
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 0.015895 1.799
R-HSA-844456 The NLRP3 inflammasome 0.016180 1.791
R-HSA-166786 Creation of C4 and C2 activators 0.015403 1.812
R-HSA-166663 Initial triggering of complement 0.019576 1.708
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.019691 1.706
R-HSA-9664433 Leishmania parasite growth and survival 0.019691 1.706
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.020163 1.695
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.020586 1.686
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.021334 1.671
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.024509 1.611
R-HSA-5218859 Regulated Necrosis 0.023665 1.626
R-HSA-162582 Signal Transduction 0.023966 1.620
R-HSA-977606 Regulation of Complement cascade 0.026135 1.583
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.027600 1.559
R-HSA-5689901 Metalloprotease DUBs 0.027600 1.559
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.027600 1.559
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.029201 1.535
R-HSA-182971 EGFR downregulation 0.035962 1.444
R-HSA-622312 Inflammasomes 0.030839 1.511
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.032391 1.490
R-HSA-5653656 Vesicle-mediated transport 0.034663 1.460
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.031453 1.502
R-HSA-5357801 Programmed Cell Death 0.035466 1.450
R-HSA-1306955 GRB7 events in ERBB2 signaling 0.046937 1.328
R-HSA-75158 TRAIL signaling 0.062092 1.207
R-HSA-8849470 PTK6 Regulates Cell Cycle 0.062092 1.207
R-HSA-426486 Small interfering RNA (siRNA) biogenesis 0.069579 1.158
R-HSA-9732724 IFNG signaling activates MAPKs 0.077008 1.113
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.084377 1.074
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.084377 1.074
R-HSA-196025 Formation of annular gap junctions 0.084377 1.074
R-HSA-190873 Gap junction degradation 0.091688 1.038
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.106136 0.974
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.113275 0.946
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.127382 0.895
R-HSA-177504 Retrograde neurotrophin signalling 0.134352 0.872
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.141267 0.850
R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 0.148127 0.829
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.175028 0.757
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.181620 0.741
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.181620 0.741
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.181620 0.741
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.181620 0.741
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.181620 0.741
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.188160 0.725
R-HSA-8943723 Regulation of PTEN mRNA translation 0.207471 0.683
R-HSA-6802957 Oncogenic MAPK signaling 0.039367 1.405
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.194649 0.711
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.113275 0.946
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.154933 0.810
R-HSA-5693607 Processing of DNA double-strand break ends 0.160047 0.796
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.054545 1.263
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.134352 0.872
R-HSA-1221632 Meiotic synapsis 0.086495 1.063
R-HSA-8856828 Clathrin-mediated endocytosis 0.139714 0.855
R-HSA-6798695 Neutrophil degranulation 0.186121 0.730
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 0.194649 0.711
R-HSA-75893 TNF signaling 0.093781 1.028
R-HSA-933541 TRAF6 mediated IRF7 activation 0.049064 1.309
R-HSA-8875513 MET interacts with TNS proteins 0.039269 1.406
R-HSA-9032845 Activated NTRK2 signals through CDK5 0.077008 1.113
R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.084377 1.074
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 0.098941 1.005
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.098941 1.005
R-HSA-8866427 VLDLR internalisation and degradation 0.120357 0.920
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.127382 0.895
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.141267 0.850
R-HSA-432720 Lysosome Vesicle Biogenesis 0.047100 1.327
R-HSA-933542 TRAF6 mediated NF-kB activation 0.213806 0.670
R-HSA-170968 Frs2-mediated activation 0.127382 0.895
R-HSA-912631 Regulation of signaling by CBL 0.175028 0.757
R-HSA-169893 Prolonged ERK activation events 0.148127 0.829
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 0.127382 0.895
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 0.091688 1.038
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.134352 0.872
R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.148127 0.829
R-HSA-193697 p75NTR regulates axonogenesis 0.091688 1.038
R-HSA-8849932 Synaptic adhesion-like molecules 0.168383 0.774
R-HSA-1500620 Meiosis 0.171332 0.766
R-HSA-187706 Signalling to p38 via RIT and RIN 0.062092 1.207
R-HSA-446107 Type I hemidesmosome assembly 0.084377 1.074
R-HSA-170984 ARMS-mediated activation 0.091688 1.038
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.188160 0.725
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.072486 1.140
R-HSA-6794362 Protein-protein interactions at synapses 0.039367 1.405
R-HSA-390650 Histamine receptors 0.039269 1.406
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.181620 0.741
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.070230 1.153
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.070230 1.153
R-HSA-9706374 FLT3 signaling through SRC family kinases 0.046937 1.328
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.084377 1.074
R-HSA-425986 Sodium/Proton exchangers 0.084377 1.074
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.141267 0.850
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.194649 0.711
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.075479 1.122
R-HSA-166166 MyD88-independent TLR4 cascade 0.075479 1.122
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.068465 1.165
R-HSA-5683057 MAPK family signaling cascades 0.172730 0.763
R-HSA-9686347 Microbial modulation of RIPK1-mediated regulated necrosis 0.077008 1.113
R-HSA-430116 GP1b-IX-V activation signalling 0.091688 1.038
R-HSA-5621481 C-type lectin receptors (CLRs) 0.067316 1.172
R-HSA-877300 Interferon gamma signaling 0.170064 0.769
R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 0.106136 0.974
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.127382 0.895
R-HSA-5620916 VxPx cargo-targeting to cilium 0.181620 0.741
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.188160 0.725
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.194649 0.711
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.065748 1.182
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.137945 0.860
R-HSA-416482 G alpha (12/13) signalling events 0.151680 0.819
R-HSA-3928662 EPHB-mediated forward signaling 0.065789 1.182
R-HSA-199991 Membrane Trafficking 0.169314 0.771
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.145256 0.838
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.148991 0.827
R-HSA-4086398 Ca2+ pathway 0.137945 0.860
R-HSA-1295596 Spry regulation of FGF signaling 0.141267 0.850
R-HSA-9768759 Regulation of NPAS4 gene expression 0.161685 0.791
R-HSA-163685 Integration of energy metabolism 0.125308 0.902
R-HSA-69206 G1/S Transition 0.103168 0.986
R-HSA-177929 Signaling by EGFR 0.093781 1.028
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.072486 1.140
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.071233 1.147
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.205879 0.686
R-HSA-73894 DNA Repair 0.190244 0.721
R-HSA-9700206 Signaling by ALK in cancer 0.071233 1.147
R-HSA-6807004 Negative regulation of MET activity 0.181620 0.741
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.207471 0.683
R-HSA-3858494 Beta-catenin independent WNT signaling 0.125308 0.902
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.194649 0.711
R-HSA-8964038 LDL clearance 0.201085 0.697
R-HSA-392517 Rap1 signalling 0.175028 0.757
R-HSA-193648 NRAGE signals death through JNK 0.093781 1.028
R-HSA-2682334 EPH-Ephrin signaling 0.049360 1.307
R-HSA-1280218 Adaptive Immune System 0.086538 1.063
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.077068 1.113
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.077068 1.113
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.211714 0.674
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.108129 0.966
R-HSA-69620 Cell Cycle Checkpoints 0.184642 0.734
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.077008 1.113
R-HSA-5689880 Ub-specific processing proteases 0.200066 0.699
R-HSA-168256 Immune System 0.080390 1.095
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.148127 0.829
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.120357 0.920
R-HSA-879518 Organic anion transport by SLCO transporters 0.207471 0.683
R-HSA-9020558 Interleukin-2 signaling 0.106136 0.974
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.140019 0.854
R-HSA-8986944 Transcriptional Regulation by MECP2 0.047041 1.328
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.091688 1.038
R-HSA-9629569 Protein hydroxylation 0.181620 0.741
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.217565 0.662
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.217565 0.662
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.217565 0.662
R-HSA-166520 Signaling by NTRKs 0.045231 1.345
R-HSA-166658 Complement cascade 0.042808 1.368
R-HSA-9758274 Regulation of NF-kappa B signaling 0.148127 0.829
R-HSA-8956321 Nucleotide salvage 0.106296 0.973
R-HSA-69615 G1/S DNA Damage Checkpoints 0.111423 0.953
R-HSA-5688426 Deubiquitination 0.071140 1.148
R-HSA-418885 DCC mediated attractive signaling 0.141267 0.850
R-HSA-8853659 RET signaling 0.047100 1.327
R-HSA-9645723 Diseases of programmed cell death 0.182744 0.738
R-HSA-193704 p75 NTR receptor-mediated signalling 0.059179 1.228
R-HSA-8848021 Signaling by PTK6 0.111423 0.953
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.111423 0.953
R-HSA-69205 G1/S-Specific Transcription 0.047100 1.327
R-HSA-210993 Tie2 Signaling 0.168383 0.774
R-HSA-422475 Axon guidance 0.169919 0.770
R-HSA-9675108 Nervous system development 0.210300 0.677
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.137945 0.860
R-HSA-6806834 Signaling by MET 0.157248 0.803
R-HSA-109581 Apoptosis 0.057535 1.240
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.207471 0.683
R-HSA-109582 Hemostasis 0.112730 0.948
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.037738 1.423
R-HSA-3700989 Transcriptional Regulation by TP53 0.042441 1.372
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.111423 0.953
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.050776 1.294
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.137553 0.862
R-HSA-9856651 MITF-M-dependent gene expression 0.152756 0.816
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.154459 0.811
R-HSA-75153 Apoptotic execution phase 0.070230 1.153
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.046888 1.329
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.143405 0.843
R-HSA-9679506 SARS-CoV Infections 0.180473 0.744
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.220091 0.657
R-HSA-9839394 TGFBR3 expression 0.220091 0.657
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.220091 0.657
R-HSA-3214842 HDMs demethylate histones 0.220091 0.657
R-HSA-400685 Sema4D in semaphorin signaling 0.220091 0.657
R-HSA-9620244 Long-term potentiation 0.220091 0.657
R-HSA-9614085 FOXO-mediated transcription 0.220496 0.657
R-HSA-3295583 TRP channels 0.226326 0.645
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.226326 0.645
R-HSA-9020702 Interleukin-1 signaling 0.226369 0.645
R-HSA-1640170 Cell Cycle 0.230640 0.637
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.232512 0.634
R-HSA-264876 Insulin processing 0.232512 0.634
R-HSA-5673001 RAF/MAP kinase cascade 0.236080 0.627
R-HSA-168898 Toll-like Receptor Cascades 0.237556 0.624
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.238648 0.622
R-HSA-73614 Pyrimidine salvage 0.238648 0.622
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.244736 0.611
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.244736 0.611
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.244736 0.611
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.244736 0.611
R-HSA-5684996 MAPK1/MAPK3 signaling 0.248156 0.605
R-HSA-2672351 Stimuli-sensing channels 0.249957 0.602
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.249957 0.602
R-HSA-2424491 DAP12 signaling 0.250775 0.601
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.250775 0.601
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.252913 0.597
R-HSA-2129379 Molecules associated with elastic fibres 0.256767 0.590
R-HSA-186763 Downstream signal transduction 0.256767 0.590
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 0.262711 0.581
R-HSA-9675126 Diseases of mitotic cell cycle 0.262711 0.581
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.264744 0.577
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.267702 0.572
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.268608 0.571
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.268608 0.571
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.268608 0.571
R-HSA-176187 Activation of ATR in response to replication stress 0.268608 0.571
R-HSA-9022692 Regulation of MECP2 expression and activity 0.268608 0.571
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.268608 0.571
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.268608 0.571
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.268608 0.571
R-HSA-354192 Integrin signaling 0.268608 0.571
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.268608 0.571
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.273619 0.563
R-HSA-390522 Striated Muscle Contraction 0.274458 0.562
R-HSA-5693537 Resolution of D-Loop Structures 0.274458 0.562
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 0.274458 0.562
R-HSA-5223345 Miscellaneous transport and binding events 0.274458 0.562
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.280261 0.552
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.280261 0.552
R-HSA-168638 NOD1/2 Signaling Pathway 0.280261 0.552
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.280261 0.552
R-HSA-5693538 Homology Directed Repair 0.285447 0.544
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.286019 0.544
R-HSA-187687 Signalling to ERKs 0.286019 0.544
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.286019 0.544
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.286019 0.544
R-HSA-9730414 MITF-M-regulated melanocyte development 0.286989 0.542
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.288401 0.540
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.288401 0.540
R-HSA-114604 GPVI-mediated activation cascade 0.291731 0.535
R-HSA-6804757 Regulation of TP53 Degradation 0.291731 0.535
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.297257 0.527
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.297257 0.527
R-HSA-1296072 Voltage gated Potassium channels 0.297397 0.527
R-HSA-110331 Cleavage of the damaged purine 0.297397 0.527
R-HSA-2132295 MHC class II antigen presentation 0.300205 0.523
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.303019 0.519
R-HSA-73927 Depurination 0.303019 0.519
R-HSA-1566948 Elastic fibre formation 0.303019 0.519
R-HSA-74217 Purine salvage 0.303019 0.519
R-HSA-8875878 MET promotes cell motility 0.303019 0.519
R-HSA-8964043 Plasma lipoprotein clearance 0.308595 0.511
R-HSA-69541 Stabilization of p53 0.308595 0.511
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.308595 0.511
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.314128 0.503
R-HSA-451927 Interleukin-2 family signaling 0.314128 0.503
R-HSA-69481 G2/M Checkpoints 0.314915 0.502
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.319617 0.495
R-HSA-3214841 PKMTs methylate histone lysines 0.319617 0.495
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.319617 0.495
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.325062 0.488
R-HSA-6811438 Intra-Golgi traffic 0.325062 0.488
R-HSA-1474165 Reproduction 0.326636 0.486
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.330464 0.481
R-HSA-3247509 Chromatin modifying enzymes 0.332805 0.478
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.335822 0.474
R-HSA-5654743 Signaling by FGFR4 0.335822 0.474
R-HSA-1433557 Signaling by SCF-KIT 0.335822 0.474
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.341139 0.467
R-HSA-69236 G1 Phase 0.341139 0.467
R-HSA-69231 Cyclin D associated events in G1 0.341139 0.467
R-HSA-2172127 DAP12 interactions 0.341139 0.467
R-HSA-190828 Gap junction trafficking 0.341139 0.467
R-HSA-375280 Amine ligand-binding receptors 0.341139 0.467
R-HSA-373752 Netrin-1 signaling 0.341139 0.467
R-HSA-6783310 Fanconi Anemia Pathway 0.346413 0.460
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.346413 0.460
R-HSA-5654741 Signaling by FGFR3 0.346413 0.460
R-HSA-5357905 Regulation of TNFR1 signaling 0.351645 0.454
R-HSA-9675135 Diseases of DNA repair 0.351645 0.454
R-HSA-9839373 Signaling by TGFBR3 0.351645 0.454
R-HSA-6807070 PTEN Regulation 0.355693 0.449
R-HSA-437239 Recycling pathway of L1 0.356836 0.448
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.356836 0.448
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.361985 0.441
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.361985 0.441
R-HSA-425410 Metal ion SLC transporters 0.361985 0.441
R-HSA-9031628 NGF-stimulated transcription 0.361985 0.441
R-HSA-4839726 Chromatin organization 0.365527 0.437
R-HSA-157858 Gap junction trafficking and regulation 0.367094 0.435
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.367196 0.435
R-HSA-9006931 Signaling by Nuclear Receptors 0.368215 0.434
R-HSA-912446 Meiotic recombination 0.377189 0.423
R-HSA-1169091 Activation of NF-kappaB in B cells 0.377189 0.423
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.382177 0.418
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.382177 0.418
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.392034 0.407
R-HSA-446652 Interleukin-1 family signaling 0.395598 0.403
R-HSA-5693532 DNA Double-Strand Break Repair 0.398407 0.400
R-HSA-5654736 Signaling by FGFR1 0.401735 0.396
R-HSA-913531 Interferon Signaling 0.406237 0.391
R-HSA-5621480 Dectin-2 family 0.406527 0.391
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.406527 0.391
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.411282 0.386
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.415999 0.381
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.415999 0.381
R-HSA-9006936 Signaling by TGFB family members 0.417901 0.379
R-HSA-5633007 Regulation of TP53 Activity 0.417901 0.379
R-HSA-8943724 Regulation of PTEN gene transcription 0.420678 0.376
R-HSA-1227986 Signaling by ERBB2 0.420678 0.376
R-HSA-450294 MAP kinase activation 0.425320 0.371
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.429925 0.367
R-HSA-186797 Signaling by PDGF 0.429925 0.367
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.429925 0.367
R-HSA-373755 Semaphorin interactions 0.434494 0.362
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.452407 0.344
R-HSA-5693606 DNA Double Strand Break Response 0.452407 0.344
R-HSA-1257604 PIP3 activates AKT signaling 0.463505 0.334
R-HSA-69202 Cyclin E associated events during G1/S transition 0.465472 0.332
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.465472 0.332
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.465472 0.332
R-HSA-448424 Interleukin-17 signaling 0.465472 0.332
R-HSA-195721 Signaling by WNT 0.469692 0.328
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.469758 0.328
R-HSA-5578749 Transcriptional regulation by small RNAs 0.474009 0.324
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.474009 0.324
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.474009 0.324
R-HSA-2559583 Cellular Senescence 0.474381 0.324
R-HSA-69473 G2/M DNA damage checkpoint 0.482411 0.317
R-HSA-983712 Ion channel transport 0.497572 0.303
R-HSA-4086400 PCP/CE pathway 0.498818 0.302
R-HSA-9955298 SLC-mediated transport of organic anions 0.498818 0.302
R-HSA-216083 Integrin cell surface interactions 0.498818 0.302
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.506827 0.295
R-HSA-9833482 PKR-mediated signaling 0.506827 0.295
R-HSA-5654738 Signaling by FGFR2 0.506827 0.295
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.514709 0.288
R-HSA-1280215 Cytokine Signaling in Immune system 0.517617 0.286
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.518603 0.285
R-HSA-9707564 Cytoprotection by HMOX1 0.518603 0.285
R-HSA-8957322 Metabolism of steroids 0.521905 0.282
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.522466 0.282
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.525024 0.280
R-HSA-5687128 MAPK6/MAPK4 signaling 0.526298 0.279
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.533871 0.273
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.533871 0.273
R-HSA-1474244 Extracellular matrix organization 0.535489 0.271
R-HSA-438064 Post NMDA receptor activation events 0.537612 0.270
R-HSA-202424 Downstream TCR signaling 0.548658 0.261
R-HSA-73884 Base Excision Repair 0.548658 0.261
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.552282 0.258
R-HSA-112316 Neuronal System 0.553040 0.257
R-HSA-9006925 Intracellular signaling by second messengers 0.556395 0.255
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.559442 0.252
R-HSA-1474290 Collagen formation 0.566489 0.247
R-HSA-1296071 Potassium Channels 0.576851 0.239
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.580249 0.236
R-HSA-8957275 Post-translational protein phosphorylation 0.583621 0.234
R-HSA-190236 Signaling by FGFR 0.583621 0.234
R-HSA-3214847 HATs acetylate histones 0.586966 0.231
R-HSA-192105 Synthesis of bile acids and bile salts 0.586966 0.231
R-HSA-8878171 Transcriptional regulation by RUNX1 0.588054 0.231
R-HSA-9705683 SARS-CoV-2-host interactions 0.592472 0.227
R-HSA-9009391 Extra-nuclear estrogen signaling 0.593576 0.227
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.596842 0.224
R-HSA-2559580 Oxidative Stress Induced Senescence 0.596842 0.224
R-HSA-1483255 PI Metabolism 0.596842 0.224
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.600081 0.222
R-HSA-9860931 Response of endothelial cells to shear stress 0.603295 0.219
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.606483 0.217
R-HSA-5696398 Nucleotide Excision Repair 0.609646 0.215
R-HSA-15869 Metabolism of nucleotides 0.609790 0.215
R-HSA-8939211 ESR-mediated signaling 0.611915 0.213
R-HSA-9692914 SARS-CoV-1-host interactions 0.612783 0.213
R-HSA-212436 Generic Transcription Pathway 0.614093 0.212
R-HSA-211000 Gene Silencing by RNA 0.615895 0.210
R-HSA-202403 TCR signaling 0.625084 0.204
R-HSA-194068 Bile acid and bile salt metabolism 0.625084 0.204
R-HSA-1483249 Inositol phosphate metabolism 0.631089 0.200
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.634055 0.198
R-HSA-9855142 Cellular responses to mechanical stimuli 0.636998 0.196
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.639917 0.194
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.642813 0.192
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.645686 0.190
R-HSA-373760 L1CAM interactions 0.648536 0.188
R-HSA-2980736 Peptide hormone metabolism 0.651363 0.186
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.654167 0.184
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.667858 0.175
R-HSA-9711123 Cellular response to chemical stress 0.673498 0.172
R-HSA-194138 Signaling by VEGF 0.675813 0.170
R-HSA-76002 Platelet activation, signaling and aggregation 0.684468 0.165
R-HSA-446728 Cell junction organization 0.691613 0.160
R-HSA-69278 Cell Cycle, Mitotic 0.695667 0.158
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.698627 0.156
R-HSA-9824446 Viral Infection Pathways 0.707732 0.150
R-HSA-9018519 Estrogen-dependent gene expression 0.708155 0.150
R-HSA-5368287 Mitochondrial translation 0.712838 0.147
R-HSA-73857 RNA Polymerase II Transcription 0.731108 0.136
R-HSA-69242 S Phase 0.737293 0.132
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.743596 0.129
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.749749 0.125
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.749749 0.125
R-HSA-1500931 Cell-Cell communication 0.753071 0.123
R-HSA-1643685 Disease 0.777991 0.109
R-HSA-418555 G alpha (s) signalling events 0.783708 0.106
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.785455 0.105
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.787187 0.104
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.787187 0.104
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.790610 0.102
R-HSA-9678108 SARS-CoV-1 Infection 0.790610 0.102
R-HSA-168255 Influenza Infection 0.797294 0.098
R-HSA-9694516 SARS-CoV-2 Infection 0.797662 0.098
R-HSA-5617833 Cilium Assembly 0.814601 0.089
R-HSA-5663205 Infectious disease 0.819506 0.086
R-HSA-382551 Transport of small molecules 0.819978 0.086
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.823415 0.084
R-HSA-389948 Co-inhibition by PD-1 0.829058 0.081
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.837084 0.077
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.846193 0.073
R-HSA-397014 Muscle contraction 0.846193 0.073
R-HSA-425407 SLC-mediated transmembrane transport 0.850825 0.070
R-HSA-68882 Mitotic Anaphase 0.851113 0.070
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.852319 0.069
R-HSA-418990 Adherens junctions interactions 0.853515 0.069
R-HSA-8951664 Neddylation 0.857045 0.067
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.867138 0.062
R-HSA-157118 Signaling by NOTCH 0.877524 0.057
R-HSA-388396 GPCR downstream signalling 0.884999 0.053
R-HSA-74160 Gene expression (Transcription) 0.886136 0.052
R-HSA-421270 Cell-cell junction organization 0.888020 0.052
R-HSA-388841 Regulation of T cell activation by CD28 family 0.892491 0.049
R-HSA-449147 Signaling by Interleukins 0.894199 0.049
R-HSA-416476 G alpha (q) signalling events 0.899279 0.046
R-HSA-1483257 Phospholipid metabolism 0.921797 0.035
R-HSA-372790 Signaling by GPCR 0.925624 0.034
R-HSA-597592 Post-translational protein modification 0.930446 0.031
R-HSA-1852241 Organelle biogenesis and maintenance 0.936256 0.029
R-HSA-112315 Transmission across Chemical Synapses 0.937802 0.028
R-HSA-212165 Epigenetic regulation of gene expression 0.937802 0.028
R-HSA-196854 Metabolism of vitamins and cofactors 0.955553 0.020
R-HSA-8953897 Cellular responses to stimuli 0.960849 0.017
R-HSA-1266738 Developmental Biology 0.961133 0.017
R-HSA-68886 M Phase 0.961974 0.017
R-HSA-9824439 Bacterial Infection Pathways 0.964394 0.016
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.965546 0.015
R-HSA-8978868 Fatty acid metabolism 0.969040 0.014
R-HSA-2262752 Cellular responses to stress 0.969955 0.013
R-HSA-72766 Translation 0.974171 0.011
R-HSA-392499 Metabolism of proteins 0.990639 0.004
R-HSA-500792 GPCR ligand binding 0.993137 0.003
R-HSA-556833 Metabolism of lipids 0.998498 0.001
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
P90RSKP90RSK 0.824 0.602 -3 0.786
SRPK2SRPK2 0.823 0.596 -3 0.867
RSK2RSK2 0.823 0.563 -3 0.790
MAPKAPK2MAPKAPK2 0.822 0.557 -3 0.772
CDKL1CDKL1 0.822 0.653 -3 0.751
RSK3RSK3 0.821 0.566 -3 0.779
MSK2MSK2 0.820 0.562 -3 0.799
PRKD2PRKD2 0.819 0.514 -3 0.734
NUAK1NUAK1 0.818 0.508 -3 0.700
PRKD3PRKD3 0.818 0.579 -3 0.774
AKT2AKT2 0.818 0.604 -3 0.845
CDKL5CDKL5 0.818 0.545 -3 0.768
MAPKAPK3MAPKAPK3 0.817 0.541 -3 0.704
SRPK1SRPK1 0.817 0.545 -3 0.820
SIKSIK 0.816 0.524 -3 0.713
PRKD1PRKD1 0.816 0.425 -3 0.657
MSK1MSK1 0.816 0.496 -3 0.780
PIM3PIM3 0.816 0.502 -3 0.685
NDR2NDR2 0.815 0.361 -3 0.619
AMPKA2AMPKA2 0.815 0.483 -3 0.658
NUAK2NUAK2 0.815 0.500 -3 0.667
RSK4RSK4 0.814 0.537 -3 0.809
SRPK3SRPK3 0.814 0.546 -3 0.816
SBKSBK 0.814 0.678 -3 0.889
PKN3PKN3 0.813 0.477 -3 0.651
NDR1NDR1 0.811 0.403 -3 0.644
AMPKA1AMPKA1 0.811 0.435 -3 0.609
PKACAPKACA 0.811 0.446 -2 0.432
PIM1PIM1 0.811 0.546 -3 0.756
PRKXPRKX 0.810 0.457 -3 0.789
MAPKAPK5MAPKAPK5 0.810 0.579 -3 0.764
PKACBPKACB 0.809 0.411 -2 0.480
BRSK1BRSK1 0.809 0.457 -3 0.697
P70S6KBP70S6KB 0.809 0.500 -3 0.725
CAMK1BCAMK1B 0.809 0.530 -3 0.626
QSKQSK 0.809 0.409 4 0.875
AKT3AKT3 0.808 0.577 -3 0.882
SGK1SGK1 0.808 0.622 -3 0.883
CHK2CHK2 0.808 0.662 -3 0.844
CAMK1DCAMK1D 0.807 0.596 -3 0.791
HIPK4HIPK4 0.807 0.377 1 0.705
ICKICK 0.807 0.489 -3 0.700
CDC7CDC7 0.806 0.156 1 0.880
PKACGPKACG 0.806 0.357 -2 0.548
AKT1AKT1 0.806 0.526 -3 0.813
SGK3SGK3 0.805 0.498 -3 0.732
P70S6KP70S6K 0.805 0.548 -3 0.799
CAMK2DCAMK2D 0.805 0.353 -3 0.596
LATS2LATS2 0.804 0.300 -5 0.740
MELKMELK 0.804 0.473 -3 0.665
CAMK4CAMK4 0.803 0.389 -3 0.621
CAMK1ACAMK1A 0.803 0.598 -3 0.820
MARK4MARK4 0.803 0.257 4 0.884
BRSK2BRSK2 0.802 0.358 -3 0.625
MYLK4MYLK4 0.802 0.422 -2 0.575
PIM2PIM2 0.801 0.545 -3 0.791
RAF1RAF1 0.801 0.202 1 0.895
TSSK1TSSK1 0.800 0.333 -3 0.596
COTCOT 0.800 0.064 2 0.831
DYRK1ADYRK1A 0.800 0.447 1 0.676
SKMLCKSKMLCK 0.799 0.347 -2 0.654
CLK4CLK4 0.799 0.454 -3 0.775
PKN2PKN2 0.799 0.356 -3 0.604
CAMK2BCAMK2B 0.799 0.327 2 0.786
CLK1CLK1 0.799 0.457 -3 0.774
DAPK2DAPK2 0.798 0.466 -3 0.599
CAMK1GCAMK1G 0.798 0.522 -3 0.756
QIKQIK 0.797 0.336 -3 0.584
CAMLCKCAMLCK 0.797 0.383 -2 0.635
CAMK2ACAMK2A 0.796 0.376 2 0.782
MOSMOS 0.796 0.173 1 0.875
PKN1PKN1 0.796 0.518 -3 0.779
TGFBR2TGFBR2 0.796 0.109 -2 0.651
IKKBIKKB 0.796 0.059 -2 0.617
PHKG1PHKG1 0.796 0.352 -3 0.637
PKG2PKG2 0.795 0.303 -2 0.482
AURCAURC 0.795 0.190 -2 0.473
TBK1TBK1 0.794 0.022 1 0.815
MARK2MARK2 0.793 0.279 4 0.824
DCAMKL1DCAMKL1 0.792 0.482 -3 0.697
CHK1CHK1 0.792 0.322 -3 0.563
NIM1NIM1 0.792 0.253 3 0.823
TSSK2TSSK2 0.792 0.250 -5 0.836
MARK3MARK3 0.791 0.274 4 0.851
AURBAURB 0.791 0.198 -2 0.468
MARK1MARK1 0.791 0.298 4 0.858
CLK2CLK2 0.791 0.439 -3 0.800
CLK3CLK3 0.790 0.226 1 0.761
IKKEIKKE 0.790 0.000 1 0.814
WNK1WNK1 0.790 0.191 -2 0.662
NIKNIK 0.789 0.352 -3 0.525
PKCDPKCD 0.789 0.273 2 0.721
PRPKPRPK 0.789 -0.029 -1 0.869
MTORMTOR 0.789 -0.012 1 0.824
GCN2GCN2 0.788 -0.057 2 0.754
PDHK4PDHK4 0.788 -0.085 1 0.872
AURAAURA 0.788 0.184 -2 0.457
LATS1LATS1 0.788 0.317 -3 0.594
PKG1PKG1 0.787 0.386 -2 0.401
HIPK1HIPK1 0.787 0.350 1 0.620
NLKNLK 0.787 0.097 1 0.790
GRK1GRK1 0.786 0.128 -2 0.773
RIPK3RIPK3 0.786 0.086 3 0.825
DYRK2DYRK2 0.786 0.254 1 0.608
DSTYKDSTYK 0.786 -0.040 2 0.821
PAK3PAK3 0.786 0.208 -2 0.568
PAK1PAK1 0.785 0.226 -2 0.575
SNRKSNRK 0.785 0.279 2 0.646
PDHK1PDHK1 0.785 -0.082 1 0.869
HUNKHUNK 0.785 0.075 2 0.742
BCKDKBCKDK 0.784 -0.016 -1 0.862
PAK6PAK6 0.784 0.154 -2 0.495
RIPK1RIPK1 0.784 0.188 1 0.806
MST4MST4 0.784 0.114 2 0.767
DAPK3DAPK3 0.784 0.461 -3 0.717
ATRATR 0.783 0.037 1 0.786
DYRK3DYRK3 0.783 0.389 1 0.623
WNK3WNK3 0.783 0.095 1 0.834
SMMLCKSMMLCK 0.783 0.447 -3 0.684
HIPK3HIPK3 0.783 0.339 1 0.651
CAMK2GCAMK2G 0.783 0.004 2 0.794
HIPK2HIPK2 0.783 0.286 1 0.517
BMPR2BMPR2 0.783 -0.081 -2 0.698
DCAMKL2DCAMKL2 0.782 0.377 -3 0.672
DAPK1DAPK1 0.782 0.460 -3 0.745
CRIKCRIK 0.782 0.547 -3 0.832
MAKMAK 0.782 0.413 -2 0.555
MNK2MNK2 0.782 0.160 -2 0.566
MASTLMASTL 0.781 0.043 -2 0.640
PAK2PAK2 0.780 0.207 -2 0.567
MRCKBMRCKB 0.780 0.460 -3 0.754
IKKAIKKA 0.780 -0.037 -2 0.622
PHKG2PHKG2 0.780 0.312 -3 0.643
KISKIS 0.779 0.047 1 0.623
GRK4GRK4 0.779 0.014 -2 0.743
ERK5ERK5 0.779 -0.004 1 0.744
PKCBPKCB 0.778 0.237 2 0.656
ULK2ULK2 0.777 -0.134 2 0.742
NEK7NEK7 0.777 -0.101 -3 0.365
PAK5PAK5 0.777 0.199 -2 0.452
BMPR1BBMPR1B 0.777 0.082 1 0.847
GRK5GRK5 0.777 -0.054 -3 0.381
MRCKAMRCKA 0.776 0.432 -3 0.731
CK1ECK1E 0.776 0.032 -3 0.259
ATMATM 0.776 0.042 1 0.737
MNK1MNK1 0.776 0.174 -2 0.587
PKCGPKCG 0.775 0.199 2 0.648
GRK6GRK6 0.775 0.017 1 0.877
SSTKSSTK 0.774 0.203 4 0.857
DLKDLK 0.774 0.095 1 0.869
DYRK1BDYRK1B 0.774 0.255 1 0.558
PKCTPKCT 0.774 0.290 2 0.660
ALK4ALK4 0.774 0.026 -2 0.694
TGFBR1TGFBR1 0.774 0.021 -2 0.683
ANKRD3ANKRD3 0.773 0.053 1 0.863
PKCHPKCH 0.773 0.231 2 0.643
MOKMOK 0.773 0.429 1 0.610
PAK4PAK4 0.773 0.183 -2 0.457
DMPK1DMPK1 0.772 0.459 -3 0.745
PASKPASK 0.772 0.379 -3 0.638
CDK7CDK7 0.771 0.034 1 0.604
PKCAPKCA 0.771 0.166 2 0.647
NEK6NEK6 0.771 -0.123 -2 0.657
ULK1ULK1 0.771 -0.147 -3 0.322
DYRK4DYRK4 0.770 0.210 1 0.540
DNAPKDNAPK 0.770 0.029 1 0.719
MLK1MLK1 0.770 -0.080 2 0.737
TTBK2TTBK2 0.769 -0.005 2 0.633
ALK2ALK2 0.769 0.049 -2 0.699
NEK9NEK9 0.768 -0.119 2 0.772
CK1DCK1D 0.768 0.024 -3 0.230
ROCK2ROCK2 0.768 0.418 -3 0.700
ACVR2AACVR2A 0.768 -0.005 -2 0.638
IRE1IRE1 0.767 0.027 1 0.739
FAM20CFAM20C 0.767 0.034 2 0.624
ACVR2BACVR2B 0.767 -0.004 -2 0.655
PKCZPKCZ 0.766 0.148 2 0.710
WNK4WNK4 0.766 0.167 -2 0.645
GRK2GRK2 0.766 0.031 -2 0.654
MEK1MEK1 0.766 0.005 2 0.798
GRK7GRK7 0.766 0.085 1 0.808
MLK2MLK2 0.765 -0.098 2 0.769
BRAFBRAF 0.765 0.086 -4 0.765
PLK1PLK1 0.765 -0.039 -2 0.630
DRAK1DRAK1 0.764 0.121 1 0.831
CHAK2CHAK2 0.764 -0.074 -1 0.823
PKCEPKCE 0.763 0.298 2 0.627
YSK4YSK4 0.763 -0.056 1 0.843
IRE2IRE2 0.762 0.001 2 0.697
ROCK1ROCK1 0.762 0.426 -3 0.729
PLK4PLK4 0.761 -0.007 2 0.597
CK1A2CK1A2 0.761 -0.002 -3 0.251
PKCIPKCI 0.760 0.198 2 0.662
CK1G1CK1G1 0.760 -0.029 -3 0.245
CDK8CDK8 0.760 -0.050 1 0.590
BMPR1ABMPR1A 0.760 0.037 1 0.841
PDK1PDK1 0.759 0.311 1 0.836
NEK2NEK2 0.758 -0.093 2 0.743
GRK3GRK3 0.757 0.027 -2 0.648
CDK19CDK19 0.757 -0.040 1 0.545
VRK2VRK2 0.756 -0.100 1 0.835
CDK14CDK14 0.756 0.093 1 0.565
PKRPKR 0.755 -0.002 1 0.801
CDK18CDK18 0.755 0.007 1 0.515
MEK5MEK5 0.755 0.020 2 0.774
MEKK3MEKK3 0.755 0.014 1 0.845
PLK3PLK3 0.755 -0.087 2 0.736
MLK3MLK3 0.754 -0.080 2 0.658
IRAK1IRAK1 0.754 0.007 -1 0.797
ZAKZAK 0.754 -0.035 1 0.836
MPSK1MPSK1 0.754 0.054 1 0.700
SMG1SMG1 0.753 -0.084 1 0.720
TLK1TLK1 0.753 -0.019 -2 0.692
TLK2TLK2 0.753 -0.091 1 0.786
HRIHRI 0.753 -0.075 -2 0.656
MEKK1MEKK1 0.752 -0.068 1 0.824
MLK4MLK4 0.752 -0.086 2 0.653
MST3MST3 0.752 0.056 2 0.740
PERKPERK 0.751 -0.061 -2 0.674
TAO3TAO3 0.751 0.056 1 0.842
P38AP38A 0.751 -0.017 1 0.633
CHAK1CHAK1 0.751 -0.065 2 0.730
IRAK4IRAK4 0.751 0.012 1 0.754
CDK13CDK13 0.750 -0.035 1 0.575
CDK9CDK9 0.750 -0.007 1 0.584
JNK2JNK2 0.750 -0.005 1 0.564
CDK10CDK10 0.749 0.112 1 0.544
MEKK2MEKK2 0.749 -0.021 2 0.752
CDK12CDK12 0.748 -0.004 1 0.552
NEK11NEK11 0.748 0.010 1 0.852
CDK17CDK17 0.748 -0.010 1 0.474
PRP4PRP4 0.748 -0.068 -3 0.296
P38BP38B 0.747 -0.024 1 0.561
RIPK2RIPK2 0.747 0.040 1 0.816
JNK3JNK3 0.747 -0.025 1 0.592
MEKK6MEKK6 0.746 0.062 1 0.822
TTBK1TTBK1 0.746 -0.057 2 0.557
NEK5NEK5 0.746 -0.097 1 0.807
HPK1HPK1 0.746 0.126 1 0.842
TAK1TAK1 0.746 0.099 1 0.875
ERK2ERK2 0.745 -0.028 1 0.595
CDK5CDK5 0.745 -0.028 1 0.612
ERK1ERK1 0.745 -0.030 1 0.554
NEK8NEK8 0.745 0.036 2 0.746
GCKGCK 0.744 0.079 1 0.854
LKB1LKB1 0.744 -0.051 -3 0.364
MAP3K15MAP3K15 0.743 0.025 1 0.830
TAO2TAO2 0.743 0.017 2 0.782
P38GP38G 0.741 -0.022 1 0.476
NEK4NEK4 0.741 -0.039 1 0.802
GAKGAK 0.740 0.037 1 0.778
CAMKK2CAMKK2 0.740 -0.088 -2 0.581
PINK1PINK1 0.740 -0.153 1 0.733
MINKMINK 0.739 0.019 1 0.835
CDK1CDK1 0.739 -0.039 1 0.557
CAMKK1CAMKK1 0.739 -0.142 -2 0.599
KHS1KHS1 0.739 0.094 1 0.827
CDK2CDK2 0.738 -0.062 1 0.652
CDK16CDK16 0.738 -0.015 1 0.485
MST2MST2 0.738 -0.066 1 0.854
KHS2KHS2 0.738 0.116 1 0.838
LOKLOK 0.737 0.052 -2 0.572
PBKPBK 0.737 0.058 1 0.693
GSK3BGSK3B 0.737 -0.018 4 0.364
HGKHGK 0.737 -0.012 3 0.843
LRRK2LRRK2 0.735 0.072 2 0.777
TNIKTNIK 0.734 0.011 3 0.829
NEK1NEK1 0.734 -0.058 1 0.802
SLKSLK 0.732 0.005 -2 0.558
CK1ACK1A 0.732 -0.014 -3 0.185
PLK2PLK2 0.732 -0.076 -3 0.280
MEK2MEK2 0.732 -0.110 2 0.775
BUB1BUB1 0.731 0.070 -5 0.755
CK2A2CK2A2 0.731 -0.019 1 0.749
NEK3NEK3 0.731 -0.047 1 0.785
MST1MST1 0.730 -0.055 1 0.835
CDK4CDK4 0.730 0.031 1 0.531
YSK1YSK1 0.729 -0.012 2 0.731
VRK1VRK1 0.729 -0.038 2 0.784
EEF2KEEF2K 0.727 -0.061 3 0.789
P38DP38D 0.727 -0.049 1 0.469
ERK7ERK7 0.726 -0.042 2 0.461
GSK3AGSK3A 0.725 -0.032 4 0.369
CDK3CDK3 0.725 -0.036 1 0.490
HASPINHASPIN 0.725 0.076 -1 0.691
TTKTTK 0.724 0.017 -2 0.659
CK2A1CK2A1 0.721 -0.029 1 0.733
STK33STK33 0.720 -0.071 2 0.556
JNK1JNK1 0.720 -0.043 1 0.545
YANK3YANK3 0.720 0.005 2 0.353
TAO1TAO1 0.719 0.015 1 0.788
CDK6CDK6 0.719 -0.034 1 0.544
ASK1ASK1 0.718 -0.039 1 0.822
PDHK3_TYRPDHK3_TYR 0.715 0.016 4 0.843
ALPHAK3ALPHAK3 0.715 0.002 -1 0.767
OSR1OSR1 0.712 -0.082 2 0.745
MAP2K4_TYRMAP2K4_TYR 0.711 0.058 -1 0.882
TESK1_TYRTESK1_TYR 0.710 0.030 3 0.875
BIKEBIKE 0.710 -0.034 1 0.619
MYO3BMYO3B 0.708 -0.055 2 0.752
PKMYT1_TYRPKMYT1_TYR 0.708 0.013 3 0.874
MYO3AMYO3A 0.707 -0.048 1 0.784
MAP2K7_TYRMAP2K7_TYR 0.707 -0.045 2 0.815
PINK1_TYRPINK1_TYR 0.706 0.093 1 0.842
CK1G3CK1G3 0.706 -0.041 -3 0.165
PDHK4_TYRPDHK4_TYR 0.706 -0.037 2 0.848
ROS1ROS1 0.706 0.025 3 0.842
MAP2K6_TYRMAP2K6_TYR 0.706 -0.014 -1 0.886
STLK3STLK3 0.705 -0.098 1 0.808
RETRET 0.705 -0.001 1 0.828
LIMK2_TYRLIMK2_TYR 0.705 0.052 -3 0.448
BMPR2_TYRBMPR2_TYR 0.704 -0.006 -1 0.859
MST1RMST1R 0.704 0.017 3 0.859
PDHK1_TYRPDHK1_TYR 0.703 -0.048 -1 0.868
EPHA6EPHA6 0.703 0.015 -1 0.826
INSRRINSRR 0.702 0.035 3 0.823
TYK2TYK2 0.702 -0.058 1 0.825
CSF1RCSF1R 0.701 -0.024 3 0.861
TYRO3TYRO3 0.701 -0.039 3 0.846
DDR1DDR1 0.701 0.026 4 0.785
JAK2JAK2 0.701 -0.069 1 0.829
EPHB4EPHB4 0.700 -0.027 -1 0.813
JAK3JAK3 0.700 -0.012 1 0.829
LIMK1_TYRLIMK1_TYR 0.699 -0.032 2 0.805
TXKTXK 0.698 0.005 1 0.860
NEK10_TYRNEK10_TYR 0.698 0.046 1 0.749
TNK2TNK2 0.698 0.050 3 0.830
JAK1JAK1 0.697 0.003 1 0.807
FERFER 0.697 -0.051 1 0.874
FGRFGR 0.697 -0.035 1 0.830
ABL2ABL2 0.697 -0.029 -1 0.806
AXLAXL 0.696 0.002 3 0.854
SRMSSRMS 0.695 -0.037 1 0.878
PDGFRBPDGFRB 0.695 -0.013 3 0.865
EPHB1EPHB1 0.694 -0.057 1 0.885
TNK1TNK1 0.694 0.032 3 0.832
FGFR2FGFR2 0.693 -0.025 3 0.860
ABL1ABL1 0.693 -0.047 -1 0.801
FGFR1FGFR1 0.693 -0.035 3 0.841
AAK1AAK1 0.692 -0.020 1 0.498
EPHB3EPHB3 0.692 -0.052 -1 0.800
KDRKDR 0.692 0.006 3 0.843
MERTKMERTK 0.692 -0.040 3 0.849
TEKTEK 0.692 -0.037 3 0.811
ITKITK 0.692 -0.042 -1 0.810
EPHB2EPHB2 0.692 -0.046 -1 0.789
HCKHCK 0.692 -0.064 -1 0.807
YES1YES1 0.692 -0.058 -1 0.810
KITKIT 0.691 -0.057 3 0.860
LCKLCK 0.691 -0.022 -1 0.804
EPHA4EPHA4 0.691 -0.045 2 0.724
FLT3FLT3 0.691 -0.018 3 0.850
DDR2DDR2 0.690 0.081 3 0.818
TNNI3K_TYRTNNI3K_TYR 0.690 -0.017 1 0.780
METMET 0.689 -0.006 3 0.846
ALKALK 0.689 -0.013 3 0.804
CK1G2CK1G2 0.689 -0.012 -3 0.203
BLKBLK 0.688 -0.005 -1 0.788
TECTEC 0.688 -0.033 -1 0.732
PDGFRAPDGFRA 0.688 -0.052 3 0.860
BTKBTK 0.686 -0.091 -1 0.787
BMXBMX 0.686 -0.030 -1 0.712
EPHA1EPHA1 0.686 -0.019 3 0.836
NTRK1NTRK1 0.686 -0.084 -1 0.838
NTRK2NTRK2 0.686 -0.075 3 0.841
YANK2YANK2 0.685 -0.049 2 0.372
LTKLTK 0.685 -0.024 3 0.820
EPHA7EPHA7 0.685 -0.041 2 0.725
ERBB2ERBB2 0.683 -0.058 1 0.807
FGFR3FGFR3 0.683 -0.040 3 0.835
NTRK3NTRK3 0.682 -0.068 -1 0.793
PTK2BPTK2B 0.682 -0.016 -1 0.770
FRKFRK 0.682 -0.052 -1 0.801
INSRINSR 0.682 -0.062 3 0.790
FYNFYN 0.682 -0.024 -1 0.775
EPHA3EPHA3 0.681 -0.069 2 0.702
FLT4FLT4 0.680 -0.054 3 0.831
FLT1FLT1 0.680 -0.059 -1 0.819
EPHA5EPHA5 0.679 -0.037 2 0.719
LYNLYN 0.679 -0.076 3 0.795
PTK6PTK6 0.676 -0.122 -1 0.770
WEE1_TYRWEE1_TYR 0.676 -0.062 -1 0.783
EPHA8EPHA8 0.674 -0.056 -1 0.769
SYKSYK 0.672 0.018 -1 0.749
SRCSRC 0.672 -0.061 -1 0.767
MATKMATK 0.671 -0.071 -1 0.727
CSKCSK 0.671 -0.092 2 0.731
PTK2PTK2 0.670 0.001 -1 0.756
EGFREGFR 0.669 -0.073 1 0.723
IGF1RIGF1R 0.669 -0.064 3 0.742
FGFR4FGFR4 0.668 -0.078 -1 0.760
EPHA2EPHA2 0.665 -0.070 -1 0.746
ERBB4ERBB4 0.662 -0.036 1 0.714
MUSKMUSK 0.661 -0.094 1 0.703
FESFES 0.656 -0.080 -1 0.702
ZAP70ZAP70 0.652 -0.007 -1 0.693