Motif 342 (n=132)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A0MRY4 | None | S291 | ochoa | Spermatogenesis-associated protein 13 | None |
| A0A0A6YYK5 | None | S23 | ochoa | Uncharacterized protein | None |
| A0A0G2JPF8 | HNRNPCL4 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C like 4 | None |
| B2RXH8 | HNRNPCL2 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| B7ZW38 | HNRNPCL3 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 3 | None |
| O00423 | EML1 | S160 | ochoa | Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) | Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {ECO:0000250|UniProtKB:Q05BC3}. |
| O00522 | KRIT1 | S109 | ochoa | Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (PubMed:26417067). {ECO:0000250|UniProtKB:Q6S5J6, ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:20616044, ECO:0000269|PubMed:20668652, ECO:0000269|PubMed:21633110, ECO:0000269|PubMed:23317506, ECO:0000269|PubMed:26417067}. |
| O14544 | SOCS6 | S70 | ochoa | Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}. |
| O14727 | APAF1 | S268 | psp | Apoptotic protease-activating factor 1 (APAF-1) | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}. |
| O15527 | OGG1 | S280 | psp | N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
| O60238 | BNIP3L | S166 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| O60240 | PLIN1 | S382 | ochoa | Perilipin-1 (Lipid droplet-associated protein) | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}. |
| O60269 | GPRIN2 | S140 | ochoa | G protein-regulated inducer of neurite outgrowth 2 (GRIN2) | May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}. |
| O60331 | PIP5K1C | S448 | psp | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). {ECO:0000250|UniProtKB:O70161, ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:12422219, ECO:0000269|PubMed:12847086, ECO:0000269|PubMed:17261850, ECO:0000269|PubMed:17635937, ECO:0000269|PubMed:22942276, ECO:0000305|PubMed:19889969}. |
| O60812 | HNRNPCL1 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| O60928 | KCNJ13 | S287 | psp | Inward rectifier potassium channel 13 (Inward rectifier K(+) channel Kir7.1) (Potassium channel, inwardly rectifying subfamily J member 13) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. {ECO:0000269|PubMed:9620703, ECO:0000269|PubMed:9738472}. |
| O75569 | PRKRA | S167 | ochoa | Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator) | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}. |
| O94875 | SORBS2 | S843 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O94885 | SASH1 | S743 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95071 | UBR5 | S90 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95810 | CAVIN2 | S85 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P00387 | CYB5R3 | S146 | ochoa | NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) | Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor. {ECO:0000269|PubMed:10807796, ECO:0000269|PubMed:1400360, ECO:0000269|PubMed:15953014, ECO:0000269|PubMed:1898726, ECO:0000269|PubMed:2019583, ECO:0000269|PubMed:8119939, ECO:0000269|PubMed:9639531}. |
| P02671 | FGA | S594 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04439 | HLA-A | S337 | psp | HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A) | Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:1402688, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:24395804, PubMed:2456340, PubMed:2784196, PubMed:28250417, PubMed:7504010, PubMed:7694806, PubMed:9862734). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17079320, PubMed:17189421, PubMed:20364150, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734). {ECO:0000269|PubMed:10449296, ECO:0000269|PubMed:12138174, ECO:0000269|PubMed:12393434, ECO:0000269|PubMed:12796775, ECO:0000269|PubMed:1402688, ECO:0000269|PubMed:15893615, ECO:0000269|PubMed:17079320, ECO:0000269|PubMed:17189421, ECO:0000269|PubMed:18275829, ECO:0000269|PubMed:19542454, ECO:0000269|PubMed:19543285, ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:21498667, ECO:0000269|PubMed:24192765, ECO:0000269|PubMed:24395804, ECO:0000269|PubMed:2456340, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:26929325, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:2784196, ECO:0000269|PubMed:28250417, ECO:0000269|PubMed:7504010, ECO:0000269|PubMed:7506728, ECO:0000269|PubMed:7679507, ECO:0000269|PubMed:7694806, ECO:0000269|PubMed:9862734}.; FUNCTION: Allele A*01:01: Presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY), SARS-CoV-2 3a/ORF3a (FTSDYYQLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at the C-terminus (PubMed:1402688, PubMed:17189421, PubMed:19177349, PubMed:20364150, PubMed:24395804, PubMed:25880248, PubMed:26758806, PubMed:30530481, PubMed:32887977, PubMed:7504010). A number of HLA-A*01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413). {ECO:0000269|PubMed:1402688, ECO:0000269|PubMed:17189421, ECO:0000269|PubMed:18779413, ECO:0000269|PubMed:19177349, ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:24395804, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:26758806, ECO:0000269|PubMed:30530481, ECO:0000269|PubMed:7504010}.; FUNCTION: Allele A*02:01: A major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at the C-terminal anchors. {ECO:0000269|PubMed:11502003, ECO:0000269|PubMed:12138174, ECO:0000269|PubMed:12796775, ECO:0000269|PubMed:17079320, ECO:0000269|PubMed:18275829, ECO:0000269|PubMed:19542454, ECO:0000269|PubMed:20619457, ECO:0000269|PubMed:22245737, ECO:0000269|PubMed:26929325, ECO:0000269|PubMed:2784196, ECO:0000269|PubMed:28250417, ECO:0000269|PubMed:7694806, ECO:0000269|PubMed:7935798, ECO:0000269|PubMed:8630735, ECO:0000269|PubMed:8805302, ECO:0000269|PubMed:8906788, ECO:0000269|PubMed:9177355}.; FUNCTION: Allele A*03:01: Presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK), SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) as well as tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and Lys or Arg anchor residues at the C-terminus (PubMed:19543285, PubMed:21943705, PubMed:2456340, PubMed:32887977, PubMed:7504010, PubMed:7679507, PubMed:9862734). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). {ECO:0000269|PubMed:19543285, ECO:0000269|PubMed:21943705, ECO:0000269|PubMed:2456340, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:7504010, ECO:0000269|PubMed:7679507, ECO:0000269|PubMed:9862734}.; FUNCTION: Allele A*11:01: Presents several immunodominant epitopes derived from HIV-1 gag-pol and HHV-4 EBNA4, containing the peptide motif with Val, Ile, Thr, Leu, Tyr or Phe at position 2 and Lys anchor residue at the C-terminus. Important in the control of HIV-1, EBV and HBV infections (PubMed:10449296). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) (PubMed:32887977). {ECO:0000269|PubMed:10449296, ECO:0000269|PubMed:32887977}.; FUNCTION: Allele A*23:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response. {ECO:0000269|PubMed:17182537}.; FUNCTION: Allele A*24:02: Presents viral epitopes derived from HIV-1 nef (RYPLTFGWCF), EBV lytic- and latent-cycle antigens BRLF1 (TYPVLEEMF), BMLF1 (DYNFVKQLF) and LMP2 (IYVLVMLVL), SARS-CoV nucleocapsid/N (QFKDNVILL), as well as tumor peptide antigens including PRAME (LYVDSLFFL), all sharing a common signature motif, namely an aromatic residue Tyr or Phe at position 2 and a nonhydrophobic anchor residue Phe, Leu or Iso at the C-terminus (PubMed:12393434, PubMed:20844028, PubMed:24192765, PubMed:9047241). Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response (PubMed:17182537, PubMed:18502829). {ECO:0000269|PubMed:12393434, ECO:0000269|PubMed:17182537, ECO:0000269|PubMed:18502829, ECO:0000269|PubMed:20844028, ECO:0000269|PubMed:24192765, ECO:0000269|PubMed:9047241}.; FUNCTION: Allele A*26:01: Presents several epitopes derived from HIV-1 gag-pol (EVIPMFSAL, ETKLGKAGY) and env (LVSDGGPNLY), carrying as anchor residues preferentially Glu at position 1, Val or Thr at position 2 and Tyr at the C-terminus. {ECO:0000269|PubMed:15893615}.; FUNCTION: Allele A*29:02: Presents peptides having a common motif, namely a Glu residue at position 2 and Tyr or Leu anchor residues at the C-terminus. {ECO:0000269|PubMed:8622959}.; FUNCTION: Allele A*32:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response. {ECO:0000269|PubMed:17182537}.; FUNCTION: Allele A*68:01: Presents viral epitopes derived from IAV NP (KTGGPIYKR) and HIV-1 tat (ITKGLGISYGR), having a common signature motif namely, Val or Thr at position 2 and positively charged residues Arg or Lys at the C-terminal anchor. {ECO:0000269|PubMed:1448153, ECO:0000269|PubMed:1448154, ECO:0000269|PubMed:2784196}.; FUNCTION: Allele A*74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at the C-terminus. May contribute to viral load control in chronic HIV-1 infection. {ECO:0000269|PubMed:21498667}. |
| P07910 | HNRNPC | S171 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P0DMR1 | HNRNPCL4 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 4 | None |
| P11940 | PABPC1 | S92 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P15923 | TCF3 | S39 | ochoa|psp | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P17509 | HOXB6 | S136 | ochoa | Homeobox protein Hox-B6 (Homeobox protein Hox-2.2) (Homeobox protein Hox-2B) (Homeobox protein Hu-2) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P21359 | NF1 | S665 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P21673 | SAT1 | S146 | psp | Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1) | Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632). {ECO:0000269|PubMed:15283699, ECO:0000269|PubMed:16455797, ECO:0000269|PubMed:17516632}. |
| P23508 | MCC | S681 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P30305 | CDC25B | S103 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P38935 | IGHMBP2 | S771 | ochoa | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:22999958, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}. |
| P40925 | MDH1 | S241 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P42684 | ABL2 | S783 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P43405 | SYK | S178 | psp | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| P43405 | SYK | S295 | psp | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| P48764 | SLC9A3 | S663 | psp | Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) | Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773). {ECO:0000250|UniProtKB:G3X939, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:24622516, ECO:0000269|PubMed:26358773, ECO:0000269|PubMed:35613257}. |
| P58340 | MLF1 | S220 | ochoa | Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}. |
| P62258 | YWHAE | S64 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S63 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P78371 | CCT2 | S60 | ochoa | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P78524 | DENND2B | S622 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q00G26 | PLIN5 | S203 | ochoa | Perilipin-5 (Lipid storage droplet protein 5) | Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). {ECO:0000250, ECO:0000269|PubMed:17234449}. |
| Q03169 | TNFAIP2 | S632 | ochoa | Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein) | May play a role as a mediator of inflammation and angiogenesis. |
| Q05586 | GRIN1 | S897 | psp | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (hNR1) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (PubMed:26875626). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:27164704, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:38538865, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761, PubMed:36309015, PubMed:38598639). {ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:21376300, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27164704, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28228639, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:38598639, ECO:0000269|PubMed:7679115, ECO:0000269|PubMed:7681588, ECO:0000269|PubMed:7685113}. |
| Q09019 | DMWD | S545 | ochoa | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}. |
| Q13310 | PABPC4 | S92 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q14643 | ITPR1 | S1764 | ochoa|psp | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000250|UniProtKB:P29994, ECO:0000269|PubMed:10620513, ECO:0000269|PubMed:27108797}. |
| Q14678 | KANK1 | S312 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q53F19 | NCBP3 | S444 | ochoa | Nuclear cap-binding protein subunit 3 (Protein ELG) | Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}. |
| Q53GT1 | KLHL22 | S281 | ochoa | Kelch-like protein 22 | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (PubMed:19995937, PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719). {ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:29769719}. |
| Q5BKX6 | SLC45A4 | S424 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5JQF8 | PABPC1L2A | S83 | ochoa | Polyadenylate-binding protein 1-like 2 (RNA-binding motif protein 32) (RNA-binding protein 32) | None |
| Q5T011 | SZT2 | S1225 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T1R4 | HIVEP3 | S2382 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T5X7 | BEND3 | S107 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5T9C2 | EEIG1 | S262 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5TGY3 | AHDC1 | S1187 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5U5Q3 | MEX3C | S446 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q63ZY3 | KANK2 | S356 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q68D10 | SPTY2D1 | S278 | ochoa | Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1) | Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026). {ECO:0000250|UniProtKB:E1BUG7, ECO:0000269|PubMed:23378026}. |
| Q6AW86 | ZNF324B | S79 | ochoa | Zinc finger protein 324B | May be involved in transcriptional regulation. |
| Q6UXY1 | BAIAP2L2 | S315 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q7L8J4 | SH3BP5L | S358 | ochoa | SH3 domain-binding protein 5-like (SH3BP-5-like) | Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}. |
| Q7Z3G6 | PRICKLE2 | S731 | ochoa | Prickle-like protein 2 | None |
| Q7Z6Z7 | HUWE1 | S1999 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86X02 | CDR2L | S393 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q86YS3 | RAB11FIP4 | S304 | ochoa | Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}. |
| Q8IZP0 | ABI1 | S240 | ochoa | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N3A8 | PARP8 | S291 | ochoa | Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q8N8U9 | BMPER | S414 | ochoa | BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2) | Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. {ECO:0000269|PubMed:14766204}. |
| Q8NEL9 | DDHD1 | S104 | psp | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8NFJ5 | GPRC5A | S301 | ochoa | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}. |
| Q8TF01 | PNISR | S726 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8TF72 | SHROOM3 | S162 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WWY3 | PRPF31 | S307 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q92576 | PHF3 | S702 | ochoa | PHD finger protein 3 | None |
| Q92618 | ZNF516 | S1121 | ochoa | Zinc finger protein 516 | Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). {ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}. |
| Q92905 | COPS5 | S177 | psp | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) | Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}. |
| Q969V6 | MRTFA | S507 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96BK5 | PINX1 | S23 | ochoa | PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) | Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}. |
| Q96L96 | ALPK3 | S1424 | ochoa | Alpha-protein kinase 3 (EC 2.7.11.1) (Muscle alpha-protein kinase) | Involved in cardiomyocyte differentiation. {ECO:0000305|PubMed:26846950, ECO:0000305|PubMed:27106955, ECO:0000305|PubMed:28630369, ECO:0000305|PubMed:30046096}. |
| Q96N67 | DOCK7 | S182 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96RR4 | CAMKK2 | S100 | ochoa|psp | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q96RR4 | CAMKK2 | S495 | ochoa|psp | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q96S21 | RAB40C | S242 | ochoa | Ras-related protein Rab-40C (EC 3.6.5.2) (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3) | RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:29156729, ECO:0000269|PubMed:35512830}. |
| Q9BZ95 | NSD3 | S659 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9C0C2 | TNKS1BP1 | S882 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H2Y7 | ZNF106 | S1279 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H361 | PABPC3 | S92 | ochoa | Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. |
| Q9H3Q1 | CDC42EP4 | S51 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H7P6 | MVB12B | S101 | psp | Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. |
| Q9NPI1 | BRD7 | S380 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NRL2 | BAZ1A | S960 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NYF8 | BCLAF1 | S319 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P2M4 | TBC1D14 | S123 | ochoa | TBC1 domain family member 14 | Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}. |
| Q9UBR4 | LHX3 | S71 | psp | LIM/homeobox protein Lhx3 (LIM homeobox protein 3) | Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2. Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (PubMed:21149718). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity). {ECO:0000250|UniProtKB:P50481, ECO:0000269|PubMed:21149718}. |
| Q9UHI6 | DDX20 | S268 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UHQ9 | CYB5R1 | S150 | ochoa | NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2) | NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}. |
| Q9UKA4 | AKAP11 | S1611 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKE5 | TNIK | S1021 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9ULC8 | ZDHHC8 | S606 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULG1 | INO80 | S47 | ochoa | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
| Q9ULH0 | KIDINS220 | S918 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULH1 | ASAP1 | S493 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9UPC5 | GPR34 | S355 | ochoa | Probable G-protein coupled receptor 34 | G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:16460680). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q9R1K6, ECO:0000269|PubMed:16460680}. |
| Q9UPU7 | TBC1D2B | S317 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9Y2K5 | R3HDM2 | S361 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y4B6 | DCAF1 | S255 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4D8 | HECTD4 | S1139 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y6R0 | NUMBL | S224 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| Q9Y6T7 | DGKB | S420 | ochoa | Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250|UniProtKB:P49621, ECO:0000250|UniProtKB:Q6NS52, ECO:0000269|PubMed:11719522, ECO:0000305}.; FUNCTION: [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity. {ECO:0000269|PubMed:11719522}. |
| Q9H2C0 | GAN | S272 | Sugiyama | Gigaxonin (Kelch-like protein 16) | Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. {ECO:0000269|PubMed:12147674, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16227972, ECO:0000269|PubMed:16303566}. |
| P41091 | EIF2S3 | T41 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| Q2VIR3 | EIF2S3B | T41 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}. |
| P49207 | RPL34 | Y32 | Sugiyama | Large ribosomal subunit protein eL34 (60S ribosomal protein L34) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P02786 | TFRC | S654 | Sugiyama | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}. |
| P27348 | YWHAQ | S63 | Sugiyama | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P31946 | YWHAB | S65 | Sugiyama | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P61981 | YWHAG | S64 | Sugiyama | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| Q04917 | YWHAH | S64 | Sugiyama | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q9H1K0 | RBSN | S548 | Sugiyama | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9HAW4 | CLSPN | S1246 | PSP | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| P10619 | CTSA | S51 | Sugiyama | Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] | Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. {ECO:0000269|PubMed:1907282}. |
| P61964 | WDR5 | S184 | Sugiyama | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| O95819 | MAP4K4 | S800 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) | Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). Phosphorylates SMAD1 on Thr-322 (PubMed:21690388). {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9890973}. |
| O43175 | PHGDH | S166 | Sugiyama | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| Q9NWZ3 | IRAK4 | S186 | Sugiyama | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q8NBP7 | PCSK9 | S595 | Sugiyama | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:17461796, PubMed:18197702, PubMed:18799458, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:18039658, ECO:0000269|PubMed:18197702, ECO:0000269|PubMed:18660751, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22074827, ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:22580899}. |
| P20941 | PDC | S54 | SIGNOR|iPTMNet | Phosducin (PHD) (33 kDa phototransducing protein) (Protein MEKA) | May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX. {ECO:0000269|PubMed:10866677}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.306792e-08 | 7.637 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.200635e-08 | 7.921 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.306792e-08 | 7.637 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.306792e-08 | 7.637 |
| R-HSA-114452 | Activation of BH3-only proteins | 9.449145e-07 | 6.025 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.859303e-06 | 5.731 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 8.195966e-06 | 5.086 |
| R-HSA-109581 | Apoptosis | 3.387378e-05 | 4.470 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.889908e-05 | 4.051 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.501153e-05 | 4.022 |
| R-HSA-5357801 | Programmed Cell Death | 1.814372e-04 | 3.741 |
| R-HSA-69481 | G2/M Checkpoints | 2.800540e-04 | 3.553 |
| R-HSA-9656249 | Defective Base Excision Repair Associated with OGG1 | 3.367100e-04 | 3.473 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.532057e-04 | 3.185 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.069828e-04 | 3.151 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 9.913695e-04 | 3.004 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.109599e-03 | 2.955 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.246170e-03 | 2.904 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.639538e-03 | 2.785 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.621912e-03 | 2.790 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.712029e-03 | 2.766 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.813872e-03 | 2.741 |
| R-HSA-9605308 | Diseases of Base Excision Repair | 2.326719e-03 | 2.633 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 3.594149e-03 | 2.444 |
| R-HSA-170984 | ARMS-mediated activation | 5.116788e-03 | 2.291 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.605434e-03 | 2.251 |
| R-HSA-199991 | Membrane Trafficking | 6.132666e-03 | 2.212 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.366141e-03 | 2.196 |
| R-HSA-9657050 | Defective OGG1 Localization | 8.718179e-03 | 2.060 |
| R-HSA-9656255 | Defective OGG1 Substrate Binding | 8.718179e-03 | 2.060 |
| R-HSA-9607240 | FLT3 Signaling | 8.922430e-03 | 2.050 |
| R-HSA-1280218 | Adaptive Immune System | 1.234782e-02 | 1.908 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.166381e-02 | 1.933 |
| R-HSA-169893 | Prolonged ERK activation events | 1.358060e-02 | 1.867 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.358060e-02 | 1.867 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.358060e-02 | 1.867 |
| R-HSA-9679506 | SARS-CoV Infections | 1.284433e-02 | 1.891 |
| R-HSA-2028269 | Signaling by Hippo | 1.624717e-02 | 1.789 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.641719e-02 | 1.785 |
| R-HSA-9656256 | Defective OGG1 Substrate Processing | 1.736089e-02 | 1.760 |
| R-HSA-392517 | Rap1 signalling | 1.911768e-02 | 1.719 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.792384e-02 | 1.747 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.176611e-02 | 1.662 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.378885e-02 | 1.624 |
| R-HSA-429947 | Deadenylation of mRNA | 2.887604e-02 | 1.539 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.807010e-02 | 1.552 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.807010e-02 | 1.552 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.647023e-02 | 1.577 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.875425e-02 | 1.541 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.887604e-02 | 1.539 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.887604e-02 | 1.539 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.061832e-02 | 1.514 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 4.284263e-02 | 1.368 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 4.284263e-02 | 1.368 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 4.284263e-02 | 1.368 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 5.946485e-02 | 1.226 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 6.766815e-02 | 1.170 |
| R-HSA-4341670 | Defective NEU1 causes sialidosis | 6.766815e-02 | 1.170 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 7.580041e-02 | 1.120 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 8.386223e-02 | 1.076 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 8.386223e-02 | 1.076 |
| R-HSA-72731 | Recycling of eIF2:GDP | 8.386223e-02 | 1.076 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 8.386223e-02 | 1.076 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 9.185423e-02 | 1.037 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 9.185423e-02 | 1.037 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 9.185423e-02 | 1.037 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.076311e-01 | 0.968 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.307876e-01 | 0.883 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.607373e-01 | 0.794 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.753256e-01 | 0.756 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.037511e-01 | 0.691 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 8.181797e-02 | 1.087 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.107041e-01 | 0.676 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.107041e-01 | 0.676 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.312035e-01 | 0.636 |
| R-HSA-72649 | Translation initiation complex formation | 1.031961e-01 | 0.986 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.973985e-02 | 1.224 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.288122e-01 | 0.890 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.288122e-01 | 0.890 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.376545e-01 | 0.861 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.917885e-02 | 1.050 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.587683e-01 | 0.799 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 9.602706e-02 | 1.018 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 9.602706e-02 | 1.018 |
| R-HSA-380287 | Centrosome maturation | 1.649085e-01 | 0.783 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.088775e-01 | 0.680 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.184645e-01 | 0.661 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.345230e-01 | 0.630 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.474201e-01 | 0.607 |
| R-HSA-192823 | Viral mRNA Translation | 2.635747e-01 | 0.579 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.231358e-01 | 0.910 |
| R-HSA-111458 | Formation of apoptosome | 1.076311e-01 | 0.968 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.254195e-01 | 0.902 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.254195e-01 | 0.902 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.152642e-01 | 0.667 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.254195e-01 | 0.902 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 6.926289e-02 | 1.159 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 8.181797e-02 | 1.087 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 8.181797e-02 | 1.087 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.920026e-01 | 0.717 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.076311e-01 | 0.968 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.770026e-01 | 0.558 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.967373e-01 | 0.706 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.346920e-01 | 0.871 |
| R-HSA-156902 | Peptide chain elongation | 2.088775e-01 | 0.680 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.899858e-02 | 1.310 |
| R-HSA-6802949 | Signaling by RAS mutants | 8.181797e-02 | 1.087 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 1.231358e-01 | 0.910 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.307876e-01 | 0.883 |
| R-HSA-4641265 | Repression of WNT target genes | 1.307876e-01 | 0.883 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.377439e-01 | 0.624 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.742565e-02 | 1.241 |
| R-HSA-5674135 | MAP2K and MAPK activation | 6.926289e-02 | 1.159 |
| R-HSA-354192 | Integrin signaling | 4.639451e-02 | 1.334 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 7.580041e-02 | 1.120 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 8.386223e-02 | 1.076 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.680632e-01 | 0.775 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.377439e-01 | 0.624 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 6.683528e-02 | 1.175 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.603422e-01 | 0.584 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 7.925356e-02 | 1.101 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.107041e-01 | 0.676 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.681361e-01 | 0.774 |
| R-HSA-2424491 | DAP12 signaling | 2.706296e-01 | 0.568 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.642009e-01 | 0.578 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 9.977699e-02 | 1.001 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.383731e-01 | 0.859 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.458928e-01 | 0.836 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.244298e-01 | 0.649 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.642009e-01 | 0.578 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.770026e-01 | 0.558 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.377439e-01 | 0.624 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.396240e-01 | 0.620 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.825250e-01 | 0.739 |
| R-HSA-170968 | Frs2-mediated activation | 1.383731e-01 | 0.859 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.280894e-01 | 0.642 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.977699e-02 | 1.001 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.066080e-02 | 1.295 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.248774e-01 | 0.648 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.742565e-02 | 1.241 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.896621e-01 | 0.722 |
| R-HSA-9620244 | Long-term potentiation | 2.379185e-01 | 0.624 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.076311e-01 | 0.968 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.458928e-01 | 0.836 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.172466e-01 | 0.931 |
| R-HSA-6798695 | Neutrophil degranulation | 2.424540e-01 | 0.615 |
| R-HSA-9711097 | Cellular response to starvation | 6.985419e-02 | 1.156 |
| R-HSA-187687 | Signalling to ERKs | 5.291131e-02 | 1.276 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.825250e-01 | 0.739 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.379185e-01 | 0.624 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.092408e-02 | 1.092 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.120684e-01 | 0.674 |
| R-HSA-5617833 | Cilium Assembly | 1.123236e-01 | 0.950 |
| R-HSA-205025 | NADE modulates death signalling | 5.118988e-02 | 1.291 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 5.946485e-02 | 1.226 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 9.185423e-02 | 1.037 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 9.185423e-02 | 1.037 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.458928e-01 | 0.836 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.533473e-01 | 0.814 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.853180e-02 | 1.314 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.143986e-01 | 0.942 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.577159e-01 | 0.589 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.642009e-01 | 0.578 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.930073e-01 | 0.714 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.526731e-01 | 0.816 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.056917e-01 | 0.687 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 9.185423e-02 | 1.037 |
| R-HSA-351200 | Interconversion of polyamines | 1.383731e-01 | 0.859 |
| R-HSA-5260271 | Diseases of Immune System | 6.443705e-02 | 1.191 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 6.443705e-02 | 1.191 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.556863e-02 | 1.341 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.571103e-01 | 0.590 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.683528e-02 | 1.175 |
| R-HSA-8951664 | Neddylation | 6.171738e-02 | 1.210 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.753256e-01 | 0.756 |
| R-HSA-6794361 | Neurexins and neuroligins | 9.771623e-02 | 1.010 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 5.118988e-02 | 1.291 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 5.946485e-02 | 1.226 |
| R-HSA-425986 | Sodium/Proton exchangers | 9.185423e-02 | 1.037 |
| R-HSA-418457 | cGMP effects | 1.458928e-01 | 0.836 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.533473e-01 | 0.814 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.107041e-01 | 0.676 |
| R-HSA-8964038 | LDL clearance | 2.175968e-01 | 0.662 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.175968e-01 | 0.662 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.244298e-01 | 0.649 |
| R-HSA-9839394 | TGFBR3 expression | 2.379185e-01 | 0.624 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.961690e-01 | 0.707 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.028455e-02 | 1.299 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.076311e-01 | 0.968 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.376545e-01 | 0.861 |
| R-HSA-525793 | Myogenesis | 2.445752e-01 | 0.612 |
| R-HSA-917937 | Iron uptake and transport | 1.649085e-01 | 0.783 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 6.766815e-02 | 1.170 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 9.977699e-02 | 1.001 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 1.154172e-01 | 0.938 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.429322e-02 | 1.354 |
| R-HSA-174362 | Transport and metabolism of PAPS | 1.533473e-01 | 0.814 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.853180e-02 | 1.314 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.607373e-01 | 0.794 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.753256e-01 | 0.756 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.967373e-01 | 0.706 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.244298e-01 | 0.649 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.321573e-02 | 1.199 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.668074e-01 | 0.574 |
| R-HSA-69275 | G2/M Transition | 2.676856e-01 | 0.572 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.724033e-01 | 0.565 |
| R-HSA-1489509 | DAG and IP3 signaling | 7.925356e-02 | 1.101 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 9.977699e-02 | 1.001 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.680632e-01 | 0.775 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.379185e-01 | 0.624 |
| R-HSA-73927 | Depurination | 5.973152e-02 | 1.224 |
| R-HSA-112043 | PLC beta mediated events | 1.229957e-01 | 0.910 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.379185e-01 | 0.624 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.379185e-01 | 0.624 |
| R-HSA-8953854 | Metabolism of RNA | 2.182671e-01 | 0.661 |
| R-HSA-4086398 | Ca2+ pathway | 1.587683e-01 | 0.799 |
| R-HSA-9675135 | Diseases of DNA repair | 8.181797e-02 | 1.087 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 9.977699e-02 | 1.001 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.458928e-01 | 0.836 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 2.642009e-01 | 0.578 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 1.967373e-01 | 0.706 |
| R-HSA-9834899 | Specification of the neural plate border | 1.896621e-01 | 0.722 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.651544e-02 | 1.332 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 7.171919e-02 | 1.144 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 8.386223e-02 | 1.076 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.458928e-01 | 0.836 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.607373e-01 | 0.794 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 1.896621e-01 | 0.722 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.107041e-01 | 0.676 |
| R-HSA-977347 | Serine metabolism | 2.107041e-01 | 0.676 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.642009e-01 | 0.578 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.794432e-02 | 1.056 |
| R-HSA-112040 | G-protein mediated events | 1.406313e-01 | 0.852 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.435483e-02 | 1.464 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.993371e-01 | 0.700 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.270344e-01 | 0.896 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 9.977699e-02 | 1.001 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.383731e-01 | 0.859 |
| R-HSA-8963896 | HDL assembly | 1.458928e-01 | 0.836 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 2.037511e-01 | 0.691 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.154172e-01 | 0.938 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 2.248774e-01 | 0.648 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 9.977699e-02 | 1.001 |
| R-HSA-168256 | Immune System | 1.828388e-01 | 0.738 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.206889e-02 | 1.207 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.409673e-01 | 0.618 |
| R-HSA-111885 | Opioid Signalling | 2.668074e-01 | 0.574 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.435483e-02 | 1.464 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.107041e-01 | 0.676 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 1.031961e-01 | 0.986 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.237042e-01 | 0.650 |
| R-HSA-9833482 | PKR-mediated signaling | 1.804336e-01 | 0.744 |
| R-HSA-9694631 | Maturation of nucleoprotein | 1.896621e-01 | 0.722 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 1.896621e-01 | 0.722 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.175968e-01 | 0.662 |
| R-HSA-73884 | Base Excision Repair | 2.152642e-01 | 0.667 |
| R-HSA-1266738 | Developmental Biology | 1.975486e-01 | 0.704 |
| R-HSA-162582 | Signal Transduction | 2.047017e-01 | 0.689 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.088775e-01 | 0.680 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.732726e-01 | 0.563 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.429322e-02 | 1.354 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.312035e-01 | 0.636 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.409673e-01 | 0.618 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.930073e-01 | 0.714 |
| R-HSA-422475 | Axon guidance | 2.286612e-01 | 0.641 |
| R-HSA-212436 | Generic Transcription Pathway | 2.149711e-01 | 0.668 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.832229e-01 | 0.737 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.710902e-01 | 0.767 |
| R-HSA-75153 | Apoptotic execution phase | 8.181797e-02 | 1.087 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.710902e-01 | 0.767 |
| R-HSA-73894 | DNA Repair | 2.409140e-01 | 0.618 |
| R-HSA-9824446 | Viral Infection Pathways | 1.312130e-01 | 0.882 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.248774e-01 | 0.648 |
| R-HSA-2559583 | Cellular Senescence | 9.843302e-02 | 1.007 |
| R-HSA-9675108 | Nervous system development | 2.776431e-01 | 0.557 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.794969e-01 | 0.554 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.797359e-01 | 0.553 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.829662e-01 | 0.548 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.865129e-01 | 0.543 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.895831e-01 | 0.538 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.895831e-01 | 0.538 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.895831e-01 | 0.538 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.895831e-01 | 0.538 |
| R-HSA-9733709 | Cardiogenesis | 2.895831e-01 | 0.538 |
| R-HSA-74160 | Gene expression (Transcription) | 2.898100e-01 | 0.538 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.957917e-01 | 0.529 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.957917e-01 | 0.529 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.001930e-01 | 0.523 |
| R-HSA-5673000 | RAF activation | 3.019463e-01 | 0.520 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.019463e-01 | 0.520 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.019463e-01 | 0.520 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.019463e-01 | 0.520 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.019463e-01 | 0.520 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.055335e-01 | 0.515 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.080475e-01 | 0.511 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 3.080475e-01 | 0.511 |
| R-HSA-381042 | PERK regulates gene expression | 3.080475e-01 | 0.511 |
| R-HSA-1640170 | Cell Cycle | 3.081279e-01 | 0.511 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.087484e-01 | 0.510 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 3.119604e-01 | 0.506 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 3.119604e-01 | 0.506 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.119604e-01 | 0.506 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.119604e-01 | 0.506 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.140958e-01 | 0.503 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.140958e-01 | 0.503 |
| R-HSA-163560 | Triglyceride catabolism | 3.140958e-01 | 0.503 |
| R-HSA-3371511 | HSF1 activation | 3.140958e-01 | 0.503 |
| R-HSA-111933 | Calmodulin induced events | 3.140958e-01 | 0.503 |
| R-HSA-111997 | CaM pathway | 3.140958e-01 | 0.503 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.140958e-01 | 0.503 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.200916e-01 | 0.495 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.247763e-01 | 0.488 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.247763e-01 | 0.488 |
| R-HSA-8875878 | MET promotes cell motility | 3.260353e-01 | 0.487 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.260353e-01 | 0.487 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.319112e-01 | 0.479 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.319274e-01 | 0.479 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.319274e-01 | 0.479 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.319274e-01 | 0.479 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 3.319274e-01 | 0.479 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.343490e-01 | 0.476 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.343490e-01 | 0.476 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.375316e-01 | 0.472 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.375316e-01 | 0.472 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.377684e-01 | 0.471 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.377684e-01 | 0.471 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.435587e-01 | 0.464 |
| R-HSA-9694548 | Maturation of spike protein | 3.435587e-01 | 0.464 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.435587e-01 | 0.464 |
| R-HSA-194138 | Signaling by VEGF | 3.470517e-01 | 0.460 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.475707e-01 | 0.459 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.492987e-01 | 0.457 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.492987e-01 | 0.457 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.492987e-01 | 0.457 |
| R-HSA-9683701 | Translation of Structural Proteins | 3.492987e-01 | 0.457 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 3.502153e-01 | 0.456 |
| R-HSA-114608 | Platelet degranulation | 3.533739e-01 | 0.452 |
| R-HSA-165159 | MTOR signalling | 3.549889e-01 | 0.450 |
| R-HSA-111996 | Ca-dependent events | 3.549889e-01 | 0.450 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.549889e-01 | 0.450 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.549889e-01 | 0.450 |
| R-HSA-73928 | Depyrimidination | 3.549889e-01 | 0.450 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.565272e-01 | 0.448 |
| R-HSA-8854214 | TBC/RABGAPs | 3.606296e-01 | 0.443 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.606296e-01 | 0.443 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.628174e-01 | 0.440 |
| R-HSA-2172127 | DAP12 interactions | 3.662214e-01 | 0.436 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.662214e-01 | 0.436 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.662214e-01 | 0.436 |
| R-HSA-9843745 | Adipogenesis | 3.690849e-01 | 0.433 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.753285e-01 | 0.426 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.772597e-01 | 0.423 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.772597e-01 | 0.423 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.772597e-01 | 0.423 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.827071e-01 | 0.417 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.877399e-01 | 0.411 |
| R-HSA-425410 | Metal ion SLC transporters | 3.881071e-01 | 0.411 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.911570e-01 | 0.408 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.939056e-01 | 0.405 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.987668e-01 | 0.399 |
| R-HSA-9664407 | Parasite infection | 4.000436e-01 | 0.398 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.000436e-01 | 0.398 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.000436e-01 | 0.398 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.010257e-01 | 0.397 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.031018e-01 | 0.395 |
| R-HSA-109582 | Hemostasis | 4.086962e-01 | 0.389 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.092422e-01 | 0.388 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.144117e-01 | 0.383 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.144117e-01 | 0.383 |
| R-HSA-4839726 | Chromatin organization | 4.193819e-01 | 0.377 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.195363e-01 | 0.377 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.272965e-01 | 0.369 |
| R-HSA-166520 | Signaling by NTRKs | 4.272965e-01 | 0.369 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.296523e-01 | 0.367 |
| R-HSA-5578775 | Ion homeostasis | 4.296523e-01 | 0.367 |
| R-HSA-5663205 | Infectious disease | 4.307729e-01 | 0.366 |
| R-HSA-5621480 | Dectin-2 family | 4.346444e-01 | 0.362 |
| R-HSA-1483166 | Synthesis of PA | 4.346444e-01 | 0.362 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.346444e-01 | 0.362 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.395932e-01 | 0.357 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.444989e-01 | 0.352 |
| R-HSA-191859 | snRNP Assembly | 4.444989e-01 | 0.352 |
| R-HSA-8979227 | Triglyceride metabolism | 4.444989e-01 | 0.352 |
| R-HSA-4085001 | Sialic acid metabolism | 4.444989e-01 | 0.352 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.444989e-01 | 0.352 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.451063e-01 | 0.352 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.480450e-01 | 0.349 |
| R-HSA-8873719 | RAB geranylgeranylation | 4.493620e-01 | 0.347 |
| R-HSA-351202 | Metabolism of polyamines | 4.493620e-01 | 0.347 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.493620e-01 | 0.347 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.541829e-01 | 0.343 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.568092e-01 | 0.340 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.589618e-01 | 0.338 |
| R-HSA-877300 | Interferon gamma signaling | 4.597130e-01 | 0.338 |
| R-HSA-373755 | Semaphorin interactions | 4.636991e-01 | 0.334 |
| R-HSA-913531 | Interferon Signaling | 4.728960e-01 | 0.325 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.740966e-01 | 0.324 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.817537e-01 | 0.317 |
| R-HSA-196807 | Nicotinate metabolism | 4.822403e-01 | 0.317 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.822403e-01 | 0.317 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.867752e-01 | 0.313 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.919620e-01 | 0.308 |
| R-HSA-9658195 | Leishmania infection | 4.919620e-01 | 0.308 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.938445e-01 | 0.306 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.957272e-01 | 0.305 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.957272e-01 | 0.305 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 4.957272e-01 | 0.305 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.966276e-01 | 0.304 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.021649e-01 | 0.299 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.021649e-01 | 0.299 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.021649e-01 | 0.299 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.021649e-01 | 0.299 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.045240e-01 | 0.297 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.045240e-01 | 0.297 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.076632e-01 | 0.294 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.088651e-01 | 0.293 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.131685e-01 | 0.290 |
| R-HSA-8852135 | Protein ubiquitination | 5.174344e-01 | 0.286 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.174344e-01 | 0.286 |
| R-HSA-382551 | Transport of small molecules | 5.175274e-01 | 0.286 |
| R-HSA-168255 | Influenza Infection | 5.185418e-01 | 0.285 |
| R-HSA-5689603 | UCH proteinases | 5.216632e-01 | 0.283 |
| R-HSA-168249 | Innate Immune System | 5.219427e-01 | 0.282 |
| R-HSA-195721 | Signaling by WNT | 5.287052e-01 | 0.277 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.292611e-01 | 0.276 |
| R-HSA-216083 | Integrin cell surface interactions | 5.300107e-01 | 0.276 |
| R-HSA-1643685 | Disease | 5.336126e-01 | 0.273 |
| R-HSA-6806834 | Signaling by MET | 5.382136e-01 | 0.269 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.422615e-01 | 0.266 |
| R-HSA-977225 | Amyloid fiber formation | 5.422615e-01 | 0.266 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.424331e-01 | 0.266 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.541952e-01 | 0.256 |
| R-HSA-68877 | Mitotic Prometaphase | 5.553500e-01 | 0.255 |
| R-HSA-72766 | Translation | 5.574168e-01 | 0.254 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.579025e-01 | 0.253 |
| R-HSA-2262752 | Cellular responses to stress | 5.619306e-01 | 0.250 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.629766e-01 | 0.250 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.696276e-01 | 0.244 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.799795e-01 | 0.237 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.799795e-01 | 0.237 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.804090e-01 | 0.236 |
| R-HSA-72172 | mRNA Splicing | 5.852960e-01 | 0.233 |
| R-HSA-391251 | Protein folding | 5.917870e-01 | 0.228 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.917870e-01 | 0.228 |
| R-HSA-2029481 | FCGR activation | 5.953684e-01 | 0.225 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.044263e-01 | 0.219 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.093850e-01 | 0.215 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.128131e-01 | 0.213 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.162114e-01 | 0.210 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.162114e-01 | 0.210 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.162114e-01 | 0.210 |
| R-HSA-422356 | Regulation of insulin secretion | 6.162114e-01 | 0.210 |
| R-HSA-597592 | Post-translational protein modification | 6.180158e-01 | 0.209 |
| R-HSA-418990 | Adherens junctions interactions | 6.183353e-01 | 0.209 |
| R-HSA-3214847 | HATs acetylate histones | 6.195800e-01 | 0.208 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.195800e-01 | 0.208 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.229193e-01 | 0.206 |
| R-HSA-112316 | Neuronal System | 6.231326e-01 | 0.205 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.257632e-01 | 0.204 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.262295e-01 | 0.203 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.295108e-01 | 0.201 |
| R-HSA-1483255 | PI Metabolism | 6.295108e-01 | 0.201 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.362970e-01 | 0.196 |
| R-HSA-162906 | HIV Infection | 6.384955e-01 | 0.195 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.391841e-01 | 0.194 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.391841e-01 | 0.194 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 6.450289e-01 | 0.190 |
| R-HSA-418346 | Platelet homeostasis | 6.454932e-01 | 0.190 |
| R-HSA-211000 | Gene Silencing by RNA | 6.486066e-01 | 0.188 |
| R-HSA-72312 | rRNA processing | 6.493330e-01 | 0.188 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.516928e-01 | 0.186 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.516928e-01 | 0.186 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.535959e-01 | 0.185 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.544271e-01 | 0.184 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.547521e-01 | 0.184 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.637709e-01 | 0.178 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.667248e-01 | 0.176 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.696530e-01 | 0.174 |
| R-HSA-5693538 | Homology Directed Repair | 6.866933e-01 | 0.163 |
| R-HSA-421270 | Cell-cell junction organization | 6.881893e-01 | 0.162 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.894473e-01 | 0.161 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.937809e-01 | 0.159 |
| R-HSA-3371556 | Cellular response to heat stress | 6.948832e-01 | 0.158 |
| R-HSA-5688426 | Deubiquitination | 6.959083e-01 | 0.157 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.992716e-01 | 0.155 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.002247e-01 | 0.155 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 7.002247e-01 | 0.155 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.028605e-01 | 0.153 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.115055e-01 | 0.148 |
| R-HSA-416476 | G alpha (q) signalling events | 7.127037e-01 | 0.147 |
| R-HSA-5576891 | Cardiac conduction | 7.255709e-01 | 0.139 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 7.255709e-01 | 0.139 |
| R-HSA-446728 | Cell junction organization | 7.372923e-01 | 0.132 |
| R-HSA-392499 | Metabolism of proteins | 7.380521e-01 | 0.132 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.389787e-01 | 0.131 |
| R-HSA-163685 | Integration of energy metabolism | 7.397450e-01 | 0.131 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.397450e-01 | 0.131 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.465570e-01 | 0.127 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.553649e-01 | 0.122 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.553649e-01 | 0.122 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.647353e-01 | 0.116 |
| R-HSA-1483257 | Phospholipid metabolism | 7.647353e-01 | 0.116 |
| R-HSA-69242 | S Phase | 7.680102e-01 | 0.115 |
| R-HSA-9758941 | Gastrulation | 7.700537e-01 | 0.113 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.720793e-01 | 0.112 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.760776e-01 | 0.110 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.780505e-01 | 0.109 |
| R-HSA-73887 | Death Receptor Signaling | 7.800062e-01 | 0.108 |
| R-HSA-9612973 | Autophagy | 7.838663e-01 | 0.106 |
| R-HSA-9610379 | HCMV Late Events | 7.857711e-01 | 0.105 |
| R-HSA-162587 | HIV Life Cycle | 7.857711e-01 | 0.105 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 7.857711e-01 | 0.105 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.913860e-01 | 0.102 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.913860e-01 | 0.102 |
| R-HSA-1500931 | Cell-Cell communication | 7.951967e-01 | 0.100 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.145244e-01 | 0.089 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.157166e-01 | 0.088 |
| R-HSA-611105 | Respiratory electron transport | 8.237050e-01 | 0.084 |
| R-HSA-3781865 | Diseases of glycosylation | 8.328383e-01 | 0.079 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.456647e-01 | 0.073 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.521309e-01 | 0.069 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.549609e-01 | 0.068 |
| R-HSA-428157 | Sphingolipid metabolism | 8.562427e-01 | 0.067 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.587728e-01 | 0.066 |
| R-HSA-68886 | M Phase | 8.704107e-01 | 0.060 |
| R-HSA-397014 | Muscle contraction | 8.707748e-01 | 0.060 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.888983e-01 | 0.051 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.911040e-01 | 0.050 |
| R-HSA-418594 | G alpha (i) signalling events | 8.913214e-01 | 0.050 |
| R-HSA-8939211 | ESR-mediated signaling | 8.965303e-01 | 0.047 |
| R-HSA-157118 | Signaling by NOTCH | 8.992561e-01 | 0.046 |
| R-HSA-9609646 | HCMV Infection | 9.078373e-01 | 0.042 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.179165e-01 | 0.037 |
| R-HSA-449147 | Signaling by Interleukins | 9.249413e-01 | 0.034 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.281930e-01 | 0.032 |
| R-HSA-1474244 | Extracellular matrix organization | 9.552826e-01 | 0.020 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.591126e-01 | 0.018 |
| R-HSA-388396 | GPCR downstream signalling | 9.722665e-01 | 0.012 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.804215e-01 | 0.009 |
| R-HSA-5668914 | Diseases of metabolism | 9.812835e-01 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 9.845294e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.854587e-01 | 0.006 |
| R-HSA-211859 | Biological oxidations | 9.921375e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.994088e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999964e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
P90RSK |
0.834 | 0.724 | -3 | 0.692 |
RSK3 |
0.833 | 0.686 | -3 | 0.687 |
RSK2 |
0.833 | 0.682 | -3 | 0.690 |
PRKD2 |
0.832 | 0.638 | -3 | 0.639 |
SRPK2 |
0.831 | 0.682 | -3 | 0.797 |
MAPKAPK2 |
0.829 | 0.668 | -3 | 0.689 |
MAPKAPK3 |
0.828 | 0.675 | -3 | 0.607 |
SBK |
0.827 | 0.786 | -3 | 0.853 |
PRKD3 |
0.827 | 0.694 | -3 | 0.683 |
AKT2 |
0.826 | 0.706 | -3 | 0.772 |
MSK2 |
0.825 | 0.663 | -3 | 0.700 |
SRPK1 |
0.825 | 0.631 | -3 | 0.724 |
SGK1 |
0.824 | 0.738 | -3 | 0.833 |
RSK4 |
0.823 | 0.641 | -3 | 0.719 |
PRKD1 |
0.823 | 0.534 | -3 | 0.537 |
PIM1 |
0.822 | 0.680 | -3 | 0.652 |
CDKL1 |
0.821 | 0.749 | -3 | 0.636 |
AKT3 |
0.821 | 0.682 | -3 | 0.824 |
NUAK1 |
0.821 | 0.577 | -3 | 0.599 |
CDKL5 |
0.820 | 0.632 | -3 | 0.660 |
CHK2 |
0.820 | 0.771 | -3 | 0.791 |
MAPKAPK5 |
0.820 | 0.702 | -3 | 0.683 |
CAMK1D |
0.819 | 0.707 | -3 | 0.723 |
MSK1 |
0.819 | 0.585 | -3 | 0.689 |
CLK1 |
0.818 | 0.578 | -3 | 0.687 |
AKT1 |
0.818 | 0.631 | -3 | 0.735 |
LATS2 |
0.818 | 0.415 | -5 | 0.779 |
PKACA |
0.817 | 0.537 | -2 | 0.579 |
NDR2 |
0.817 | 0.448 | -3 | 0.484 |
SGK3 |
0.817 | 0.614 | -3 | 0.634 |
SIK |
0.816 | 0.583 | -3 | 0.614 |
CAMK1A |
0.816 | 0.702 | -3 | 0.759 |
SRPK3 |
0.816 | 0.608 | -3 | 0.724 |
PIM3 |
0.816 | 0.602 | -3 | 0.559 |
P70S6KB |
0.816 | 0.612 | -3 | 0.621 |
P70S6K |
0.815 | 0.657 | -3 | 0.723 |
MELK |
0.815 | 0.591 | -3 | 0.561 |
PRKX |
0.815 | 0.548 | -3 | 0.715 |
PKN3 |
0.813 | 0.562 | -3 | 0.534 |
NUAK2 |
0.813 | 0.564 | -3 | 0.542 |
PKACB |
0.813 | 0.497 | -2 | 0.626 |
NDR1 |
0.813 | 0.504 | -3 | 0.521 |
AMPKA2 |
0.812 | 0.535 | -3 | 0.543 |
CLK4 |
0.812 | 0.560 | -3 | 0.680 |
PIM2 |
0.811 | 0.658 | -3 | 0.704 |
CAMK2D |
0.811 | 0.467 | -3 | 0.468 |
PKACG |
0.811 | 0.455 | -2 | 0.689 |
BRSK1 |
0.809 | 0.519 | -3 | 0.593 |
PKN1 |
0.808 | 0.621 | -3 | 0.697 |
TSSK1 |
0.808 | 0.423 | -3 | 0.462 |
DCAMKL1 |
0.808 | 0.620 | -3 | 0.594 |
CAMK1G |
0.808 | 0.620 | -3 | 0.662 |
CAMK1B |
0.808 | 0.631 | -3 | 0.493 |
AMPKA1 |
0.808 | 0.478 | -3 | 0.480 |
PHKG1 |
0.806 | 0.465 | -3 | 0.517 |
ICK |
0.806 | 0.574 | -3 | 0.572 |
CAMK4 |
0.805 | 0.473 | -3 | 0.502 |
HIPK4 |
0.805 | 0.433 | 1 | 0.683 |
DYRK1A |
0.803 | 0.515 | 1 | 0.647 |
BRSK2 |
0.803 | 0.409 | -3 | 0.511 |
QSK |
0.803 | 0.430 | 4 | 0.675 |
CAMK2A |
0.803 | 0.475 | 2 | 0.790 |
PKG2 |
0.801 | 0.394 | -2 | 0.630 |
MYLK4 |
0.801 | 0.487 | -2 | 0.709 |
PHKG2 |
0.800 | 0.446 | -3 | 0.537 |
PKN2 |
0.800 | 0.435 | -3 | 0.478 |
CAMK2B |
0.798 | 0.402 | 2 | 0.779 |
PKCD |
0.798 | 0.385 | 2 | 0.801 |
WNK1 |
0.797 | 0.308 | -2 | 0.851 |
SKMLCK |
0.797 | 0.396 | -2 | 0.811 |
CLK2 |
0.797 | 0.515 | -3 | 0.716 |
DCAMKL2 |
0.796 | 0.492 | -3 | 0.564 |
PKG1 |
0.796 | 0.476 | -2 | 0.556 |
AURC |
0.795 | 0.257 | -2 | 0.600 |
QIK |
0.795 | 0.384 | -3 | 0.451 |
NIM1 |
0.794 | 0.329 | 3 | 0.766 |
MARK4 |
0.794 | 0.253 | 4 | 0.698 |
CAMLCK |
0.794 | 0.459 | -2 | 0.802 |
DAPK2 |
0.793 | 0.537 | -3 | 0.460 |
PAK3 |
0.793 | 0.300 | -2 | 0.723 |
MNK2 |
0.793 | 0.259 | -2 | 0.756 |
CHK1 |
0.792 | 0.393 | -3 | 0.452 |
TSSK2 |
0.792 | 0.317 | -5 | 0.806 |
AURB |
0.792 | 0.262 | -2 | 0.594 |
LATS1 |
0.792 | 0.408 | -3 | 0.451 |
MRCKB |
0.792 | 0.569 | -3 | 0.671 |
DYRK3 |
0.791 | 0.463 | 1 | 0.616 |
PAK1 |
0.791 | 0.312 | -2 | 0.719 |
CRIK |
0.791 | 0.646 | -3 | 0.749 |
MRCKA |
0.790 | 0.551 | -3 | 0.639 |
TBK1 |
0.790 | 0.072 | 1 | 0.813 |
WNK3 |
0.790 | 0.203 | 1 | 0.824 |
NIK |
0.790 | 0.473 | -3 | 0.382 |
RAF1 |
0.790 | 0.210 | 1 | 0.857 |
PKCB |
0.789 | 0.345 | 2 | 0.748 |
CLK3 |
0.789 | 0.284 | 1 | 0.705 |
SMMLCK |
0.788 | 0.541 | -3 | 0.568 |
DYRK2 |
0.788 | 0.305 | 1 | 0.584 |
HIPK1 |
0.788 | 0.400 | 1 | 0.612 |
HIPK3 |
0.787 | 0.406 | 1 | 0.637 |
PKCH |
0.787 | 0.352 | 2 | 0.760 |
PKCT |
0.787 | 0.404 | 2 | 0.767 |
PKCG |
0.787 | 0.304 | 2 | 0.749 |
SNRK |
0.786 | 0.356 | 2 | 0.784 |
PAK6 |
0.786 | 0.213 | -2 | 0.638 |
CDC7 |
0.786 | 0.072 | 1 | 0.752 |
PKCA |
0.786 | 0.278 | 2 | 0.743 |
COT |
0.786 | 0.023 | 2 | 0.863 |
MNK1 |
0.786 | 0.269 | -2 | 0.760 |
MST4 |
0.785 | 0.190 | 2 | 0.825 |
MARK3 |
0.785 | 0.262 | 4 | 0.644 |
MARK2 |
0.785 | 0.253 | 4 | 0.611 |
MARK1 |
0.785 | 0.299 | 4 | 0.665 |
HIPK2 |
0.784 | 0.328 | 1 | 0.502 |
ULK2 |
0.784 | -0.028 | 2 | 0.844 |
BCKDK |
0.784 | 0.060 | -1 | 0.850 |
PDHK1 |
0.784 | 0.027 | 1 | 0.855 |
PAK2 |
0.783 | 0.283 | -2 | 0.696 |
TGFBR2 |
0.783 | 0.111 | -2 | 0.765 |
PDHK4 |
0.783 | -0.028 | 1 | 0.841 |
PRPK |
0.782 | -0.001 | -1 | 0.870 |
IKKE |
0.782 | 0.038 | 1 | 0.803 |
MTOR |
0.782 | 0.020 | 1 | 0.781 |
NLK |
0.782 | 0.120 | 1 | 0.764 |
PKCZ |
0.781 | 0.276 | 2 | 0.809 |
MAK |
0.781 | 0.474 | -2 | 0.680 |
IKKB |
0.781 | 0.072 | -2 | 0.706 |
AURA |
0.781 | 0.229 | -2 | 0.557 |
PKCE |
0.780 | 0.413 | 2 | 0.732 |
RIPK1 |
0.780 | 0.208 | 1 | 0.807 |
WNK4 |
0.779 | 0.311 | -2 | 0.849 |
GCN2 |
0.779 | -0.060 | 2 | 0.849 |
RIPK3 |
0.779 | 0.074 | 3 | 0.713 |
MOK |
0.779 | 0.507 | 1 | 0.596 |
ROCK2 |
0.779 | 0.530 | -3 | 0.597 |
DAPK3 |
0.778 | 0.519 | -3 | 0.608 |
PAK5 |
0.778 | 0.258 | -2 | 0.562 |
DMPK1 |
0.777 | 0.549 | -3 | 0.648 |
ULK1 |
0.777 | -0.070 | -3 | 0.169 |
HUNK |
0.777 | 0.058 | 2 | 0.825 |
DAPK1 |
0.777 | 0.517 | -3 | 0.640 |
ROCK1 |
0.776 | 0.538 | -3 | 0.643 |
DYRK1B |
0.776 | 0.303 | 1 | 0.537 |
MASTL |
0.775 | 0.089 | -2 | 0.779 |
NEK9 |
0.775 | -0.006 | 2 | 0.865 |
SSTK |
0.775 | 0.247 | 4 | 0.688 |
CAMK2G |
0.775 | 0.015 | 2 | 0.824 |
NEK7 |
0.775 | -0.059 | -3 | 0.190 |
ATR |
0.775 | 0.051 | 1 | 0.757 |
PKCI |
0.774 | 0.310 | 2 | 0.776 |
DSTYK |
0.774 | -0.077 | 2 | 0.862 |
NEK6 |
0.773 | -0.053 | -2 | 0.862 |
PAK4 |
0.773 | 0.237 | -2 | 0.569 |
BMPR2 |
0.772 | -0.094 | -2 | 0.865 |
NEK2 |
0.772 | 0.034 | 2 | 0.844 |
MOS |
0.772 | -0.000 | 1 | 0.789 |
IRE1 |
0.770 | 0.079 | 1 | 0.747 |
DYRK4 |
0.770 | 0.247 | 1 | 0.513 |
ANKRD3 |
0.769 | 0.097 | 1 | 0.849 |
DLK |
0.768 | 0.145 | 1 | 0.813 |
ERK5 |
0.766 | -0.031 | 1 | 0.682 |
CDK7 |
0.765 | 0.042 | 1 | 0.575 |
GRK6 |
0.765 | 0.016 | 1 | 0.790 |
CHAK2 |
0.764 | -0.012 | -1 | 0.878 |
PLK4 |
0.764 | 0.055 | 2 | 0.723 |
IRE2 |
0.764 | 0.046 | 2 | 0.801 |
PLK1 |
0.764 | 0.022 | -2 | 0.796 |
MLK1 |
0.763 | -0.066 | 2 | 0.829 |
TTBK2 |
0.763 | -0.041 | 2 | 0.753 |
IKKA |
0.763 | -0.048 | -2 | 0.702 |
GRK5 |
0.763 | -0.096 | -3 | 0.207 |
PASK |
0.763 | 0.400 | -3 | 0.491 |
ATM |
0.762 | 0.024 | 1 | 0.697 |
IRAK4 |
0.762 | 0.121 | 1 | 0.781 |
PKR |
0.762 | 0.113 | 1 | 0.802 |
DNAPK |
0.761 | 0.041 | 1 | 0.706 |
DRAK1 |
0.759 | 0.143 | 1 | 0.733 |
CHAK1 |
0.759 | 0.036 | 2 | 0.818 |
MLK2 |
0.759 | -0.068 | 2 | 0.838 |
PDK1 |
0.758 | 0.384 | 1 | 0.817 |
YSK4 |
0.757 | -0.004 | 1 | 0.806 |
HRI |
0.757 | -0.001 | -2 | 0.837 |
MEK1 |
0.757 | 0.026 | 2 | 0.868 |
CDK8 |
0.757 | -0.041 | 1 | 0.567 |
CDK14 |
0.756 | 0.112 | 1 | 0.561 |
CDK10 |
0.756 | 0.152 | 1 | 0.542 |
BRAF |
0.756 | 0.095 | -4 | 0.821 |
VRK2 |
0.755 | 0.003 | 1 | 0.823 |
PLK3 |
0.755 | -0.036 | 2 | 0.796 |
CDK19 |
0.755 | -0.031 | 1 | 0.530 |
ALK4 |
0.754 | -0.029 | -2 | 0.793 |
CK1G1 |
0.754 | -0.067 | -3 | 0.091 |
IRAK1 |
0.754 | 0.039 | -1 | 0.803 |
GRK4 |
0.754 | -0.120 | -2 | 0.769 |
CDK9 |
0.752 | 0.019 | 1 | 0.566 |
NEK5 |
0.752 | -0.000 | 1 | 0.812 |
CDK18 |
0.751 | 0.007 | 1 | 0.502 |
MEK5 |
0.751 | 0.064 | 2 | 0.863 |
CK1E |
0.751 | -0.082 | -3 | 0.103 |
MEKK1 |
0.751 | -0.020 | 1 | 0.821 |
PERK |
0.750 | -0.028 | -2 | 0.797 |
SMG1 |
0.750 | -0.062 | 1 | 0.711 |
MST3 |
0.750 | 0.103 | 2 | 0.818 |
TLK2 |
0.749 | -0.058 | 1 | 0.751 |
FAM20C |
0.749 | -0.004 | 2 | 0.570 |
TGFBR1 |
0.749 | -0.046 | -2 | 0.769 |
CDK13 |
0.749 | -0.020 | 1 | 0.552 |
ZAK |
0.748 | -0.010 | 1 | 0.800 |
KIS |
0.748 | -0.057 | 1 | 0.598 |
MLK3 |
0.748 | -0.063 | 2 | 0.751 |
CDK12 |
0.747 | 0.014 | 1 | 0.528 |
RIPK2 |
0.747 | 0.092 | 1 | 0.789 |
JNK2 |
0.747 | -0.000 | 1 | 0.535 |
P38A |
0.746 | -0.009 | 1 | 0.596 |
CDK5 |
0.746 | -0.008 | 1 | 0.584 |
GRK1 |
0.746 | -0.068 | -2 | 0.687 |
NEK11 |
0.746 | 0.038 | 1 | 0.818 |
NEK8 |
0.745 | 0.100 | 2 | 0.851 |
MEKK3 |
0.745 | -0.029 | 1 | 0.809 |
TAO3 |
0.745 | 0.092 | 1 | 0.803 |
TLK1 |
0.745 | -0.032 | -2 | 0.809 |
MEKK2 |
0.745 | -0.004 | 2 | 0.848 |
CK1A2 |
0.745 | -0.077 | -3 | 0.103 |
PRP4 |
0.745 | -0.056 | -3 | 0.174 |
GRK7 |
0.745 | 0.017 | 1 | 0.720 |
NEK4 |
0.745 | 0.038 | 1 | 0.822 |
ACVR2A |
0.745 | -0.051 | -2 | 0.769 |
PINK1 |
0.744 | -0.093 | 1 | 0.740 |
PBK |
0.744 | 0.152 | 1 | 0.741 |
NEK3 |
0.744 | 0.057 | 1 | 0.783 |
LOK |
0.744 | 0.151 | -2 | 0.739 |
ALK2 |
0.743 | -0.045 | -2 | 0.770 |
MLK4 |
0.743 | -0.085 | 2 | 0.751 |
CDK17 |
0.743 | -0.013 | 1 | 0.449 |
BMPR1B |
0.743 | -0.042 | 1 | 0.698 |
TTBK1 |
0.742 | -0.060 | 2 | 0.674 |
MEKK6 |
0.742 | 0.108 | 1 | 0.776 |
MPSK1 |
0.742 | 0.020 | 1 | 0.750 |
ERK2 |
0.742 | -0.025 | 1 | 0.567 |
CK1D |
0.742 | -0.092 | -3 | 0.078 |
GSK3B |
0.742 | 0.021 | 4 | 0.414 |
TAO2 |
0.742 | 0.077 | 2 | 0.851 |
CDK2 |
0.741 | -0.022 | 1 | 0.608 |
MAP3K15 |
0.741 | 0.070 | 1 | 0.793 |
JNK3 |
0.741 | -0.029 | 1 | 0.557 |
LKB1 |
0.740 | -0.022 | -3 | 0.214 |
LRRK2 |
0.740 | 0.186 | 2 | 0.877 |
BUB1 |
0.739 | 0.132 | -5 | 0.730 |
ERK1 |
0.739 | -0.030 | 1 | 0.522 |
NEK1 |
0.739 | 0.031 | 1 | 0.815 |
HPK1 |
0.739 | 0.159 | 1 | 0.820 |
P38G |
0.739 | -0.018 | 1 | 0.443 |
KHS1 |
0.738 | 0.160 | 1 | 0.825 |
GCK |
0.738 | 0.109 | 1 | 0.822 |
GRK2 |
0.738 | -0.053 | -2 | 0.661 |
CAMKK2 |
0.738 | -0.032 | -2 | 0.713 |
ACVR2B |
0.738 | -0.088 | -2 | 0.774 |
HGK |
0.737 | 0.050 | 3 | 0.763 |
GAK |
0.737 | 0.072 | 1 | 0.810 |
KHS2 |
0.736 | 0.168 | 1 | 0.832 |
TNIK |
0.735 | 0.077 | 3 | 0.772 |
CDK4 |
0.735 | 0.058 | 1 | 0.515 |
MINK |
0.735 | 0.062 | 1 | 0.832 |
P38B |
0.734 | -0.035 | 1 | 0.515 |
CAMKK1 |
0.734 | -0.101 | -2 | 0.721 |
YSK1 |
0.734 | 0.073 | 2 | 0.829 |
CDK1 |
0.733 | -0.035 | 1 | 0.517 |
GSK3A |
0.733 | 0.008 | 4 | 0.417 |
SLK |
0.731 | 0.071 | -2 | 0.667 |
CDK3 |
0.731 | 0.002 | 1 | 0.463 |
CDK16 |
0.731 | -0.018 | 1 | 0.468 |
STK33 |
0.730 | -0.000 | 2 | 0.668 |
EEF2K |
0.730 | -0.013 | 3 | 0.741 |
HASPIN |
0.728 | 0.122 | -1 | 0.753 |
TAK1 |
0.728 | 0.050 | 1 | 0.832 |
VRK1 |
0.728 | 0.029 | 2 | 0.857 |
MEK2 |
0.727 | -0.067 | 2 | 0.863 |
BMPR1A |
0.727 | -0.060 | 1 | 0.687 |
MST2 |
0.727 | -0.061 | 1 | 0.822 |
GRK3 |
0.726 | -0.059 | -2 | 0.606 |
CDK6 |
0.726 | -0.006 | 1 | 0.546 |
MST1 |
0.725 | -0.022 | 1 | 0.817 |
PLK2 |
0.723 | -0.073 | -3 | 0.138 |
ERK7 |
0.723 | -0.008 | 2 | 0.557 |
TAO1 |
0.722 | 0.089 | 1 | 0.767 |
P38D |
0.722 | -0.044 | 1 | 0.461 |
BIKE |
0.719 | 0.055 | 1 | 0.711 |
CK2A2 |
0.717 | -0.017 | 1 | 0.612 |
TTK |
0.717 | 0.028 | -2 | 0.800 |
MYO3B |
0.715 | 0.029 | 2 | 0.834 |
ASK1 |
0.715 | 0.001 | 1 | 0.784 |
JNK1 |
0.714 | -0.050 | 1 | 0.509 |
LIMK2_TYR |
0.710 | 0.162 | -3 | 0.297 |
PKMYT1_TYR |
0.709 | 0.109 | 3 | 0.801 |
PDHK3_TYR |
0.709 | 0.035 | 4 | 0.748 |
OSR1 |
0.709 | -0.049 | 2 | 0.834 |
CK2A1 |
0.708 | -0.025 | 1 | 0.592 |
YANK3 |
0.708 | 0.007 | 2 | 0.412 |
TESK1_TYR |
0.707 | 0.085 | 3 | 0.833 |
CK1A |
0.706 | -0.108 | -3 | 0.045 |
MAP2K4_TYR |
0.706 | 0.109 | -1 | 0.878 |
MYO3A |
0.706 | -0.002 | 1 | 0.796 |
LIMK1_TYR |
0.705 | 0.095 | 2 | 0.880 |
MAP2K7_TYR |
0.704 | 0.040 | 2 | 0.881 |
AAK1 |
0.703 | 0.063 | 1 | 0.611 |
PINK1_TYR |
0.703 | 0.160 | 1 | 0.800 |
RET |
0.702 | 0.064 | 1 | 0.802 |
CK1G3 |
0.701 | -0.089 | -3 | 0.035 |
STLK3 |
0.700 | -0.065 | 1 | 0.779 |
DDR1 |
0.699 | 0.063 | 4 | 0.686 |
NEK10_TYR |
0.699 | 0.117 | 1 | 0.718 |
TNK2 |
0.699 | 0.073 | 3 | 0.727 |
MAP2K6_TYR |
0.697 | -0.020 | -1 | 0.869 |
TNK1 |
0.697 | 0.110 | 3 | 0.728 |
PDHK4_TYR |
0.696 | -0.071 | 2 | 0.881 |
MST1R |
0.695 | 0.007 | 3 | 0.760 |
ROS1 |
0.695 | 0.011 | 3 | 0.718 |
TYK2 |
0.695 | -0.030 | 1 | 0.803 |
TNNI3K_TYR |
0.695 | 0.048 | 1 | 0.793 |
TYRO3 |
0.694 | -0.036 | 3 | 0.745 |
ALPHAK3 |
0.693 | -0.077 | -1 | 0.772 |
PDHK1_TYR |
0.692 | -0.094 | -1 | 0.863 |
JAK2 |
0.690 | -0.076 | 1 | 0.801 |
BMPR2_TYR |
0.690 | -0.074 | -1 | 0.824 |
EPHB4 |
0.689 | -0.048 | -1 | 0.841 |
AXL |
0.689 | 0.004 | 3 | 0.741 |
JAK1 |
0.689 | 0.014 | 1 | 0.780 |
PDGFRB |
0.689 | -0.002 | 3 | 0.758 |
EPHA6 |
0.688 | -0.038 | -1 | 0.830 |
CSF1R |
0.688 | -0.069 | 3 | 0.741 |
JAK3 |
0.687 | -0.034 | 1 | 0.773 |
DDR2 |
0.686 | 0.112 | 3 | 0.699 |
ABL2 |
0.686 | -0.039 | -1 | 0.831 |
FGR |
0.685 | -0.076 | 1 | 0.814 |
PDGFRA |
0.684 | -0.029 | 3 | 0.749 |
ABL1 |
0.684 | -0.052 | -1 | 0.832 |
YES1 |
0.683 | -0.065 | -1 | 0.848 |
KDR |
0.683 | -0.014 | 3 | 0.719 |
FGFR1 |
0.683 | -0.049 | 3 | 0.730 |
INSRR |
0.682 | -0.036 | 3 | 0.710 |
FGFR2 |
0.681 | -0.054 | 3 | 0.749 |
FLT3 |
0.680 | -0.041 | 3 | 0.731 |
TXK |
0.680 | -0.055 | 1 | 0.761 |
EPHB3 |
0.680 | -0.082 | -1 | 0.831 |
FER |
0.678 | -0.140 | 1 | 0.801 |
TEK |
0.678 | -0.082 | 3 | 0.693 |
LTK |
0.678 | -0.014 | 3 | 0.702 |
EPHA1 |
0.678 | -0.024 | 3 | 0.711 |
ITK |
0.678 | -0.069 | -1 | 0.797 |
MERTK |
0.678 | -0.075 | 3 | 0.739 |
SRMS |
0.678 | -0.113 | 1 | 0.785 |
EPHB1 |
0.678 | -0.106 | 1 | 0.782 |
ALK |
0.678 | -0.028 | 3 | 0.681 |
WEE1_TYR |
0.676 | -0.036 | -1 | 0.785 |
KIT |
0.676 | -0.109 | 3 | 0.744 |
EPHB2 |
0.675 | -0.097 | -1 | 0.813 |
PTK6 |
0.675 | -0.085 | -1 | 0.784 |
HCK |
0.675 | -0.122 | -1 | 0.794 |
BTK |
0.674 | -0.119 | -1 | 0.787 |
NTRK2 |
0.674 | -0.091 | 3 | 0.726 |
TEC |
0.674 | -0.060 | -1 | 0.773 |
EPHA4 |
0.674 | -0.106 | 2 | 0.763 |
PTK2B |
0.673 | -0.030 | -1 | 0.814 |
NTRK1 |
0.673 | -0.110 | -1 | 0.832 |
MET |
0.672 | -0.091 | 3 | 0.748 |
LCK |
0.672 | -0.094 | -1 | 0.785 |
FLT4 |
0.670 | -0.071 | 3 | 0.705 |
YANK2 |
0.670 | -0.060 | 2 | 0.431 |
BLK |
0.669 | -0.077 | -1 | 0.793 |
EPHA7 |
0.669 | -0.084 | 2 | 0.783 |
FLT1 |
0.669 | -0.092 | -1 | 0.792 |
EPHA3 |
0.668 | -0.097 | 2 | 0.756 |
INSR |
0.668 | -0.082 | 3 | 0.683 |
BMX |
0.668 | -0.074 | -1 | 0.716 |
FGFR3 |
0.667 | -0.093 | 3 | 0.733 |
ERBB2 |
0.666 | -0.124 | 1 | 0.754 |
NTRK3 |
0.665 | -0.109 | -1 | 0.788 |
FRK |
0.663 | -0.116 | -1 | 0.809 |
CSK |
0.661 | -0.090 | 2 | 0.791 |
EPHA5 |
0.660 | -0.094 | 2 | 0.761 |
LYN |
0.660 | -0.134 | 3 | 0.665 |
FYN |
0.659 | -0.111 | -1 | 0.745 |
MATK |
0.657 | -0.107 | -1 | 0.774 |
MUSK |
0.656 | -0.079 | 1 | 0.643 |
SRC |
0.655 | -0.112 | -1 | 0.779 |
CK1G2 |
0.655 | -0.120 | -3 | 0.062 |
EPHA8 |
0.655 | -0.116 | -1 | 0.787 |
EGFR |
0.654 | -0.109 | 1 | 0.664 |
FGFR4 |
0.653 | -0.110 | -1 | 0.779 |
IGF1R |
0.647 | -0.107 | 3 | 0.637 |
EPHA2 |
0.644 | -0.120 | -1 | 0.737 |
FES |
0.639 | -0.121 | -1 | 0.718 |
PTK2 |
0.638 | -0.105 | -1 | 0.691 |
ERBB4 |
0.638 | -0.112 | 1 | 0.645 |
SYK |
0.636 | -0.142 | -1 | 0.691 |
ZAP70 |
0.617 | -0.110 | -1 | 0.636 |