Motif 341 (n=272)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PNV4 | None | S502 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| A1A5D9 | BICDL2 | S277 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| A8MVW0 | FAM171A2 | S664 | ochoa | Protein FAM171A2 | None |
| B2RTY4 | MYO9A | S813 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| B2RTY4 | MYO9A | S1307 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| O00560 | SDCBP | S131 | ochoa|psp | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}. |
| O00562 | PITPNM1 | S664 | ochoa | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
| O14513 | NCKAP5 | S1311 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14607 | UTY | S501 | ochoa | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}. |
| O14647 | CHD2 | S1728 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
| O14727 | APAF1 | S268 | psp | Apoptotic protease-activating factor 1 (APAF-1) | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}. |
| O14827 | RASGRF2 | S746 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O15014 | ZNF609 | S379 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15018 | PDZD2 | S2341 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15143 | ARPC1B | S170 | ochoa | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| O15211 | RGL2 | S187 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15530 | PDPK1 | S241 | ochoa|psp | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
| O43310 | CTIF | S328 | ochoa | CBP80/20-dependent translation initiation factor | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}. |
| O43823 | AKAP8 | S165 | ochoa | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. |
| O60237 | PPP1R12B | S420 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60343 | TBC1D4 | S673 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60381 | HBP1 | S380 | ochoa|psp | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| O60563 | CCNT1 | S577 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O60664 | PLIN3 | S31 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75376 | NCOR1 | Y89 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75427 | LRCH4 | S432 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75643 | SNRNP200 | S1478 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O94888 | UBXN7 | S280 | ochoa | UBX domain-containing protein 7 | Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}. |
| O94921 | CDK14 | S95 | ochoa | Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}. |
| O95071 | UBR5 | S1549 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95210 | STBD1 | S145 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| P09525 | ANXA4 | S125 | ochoa | Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}. |
| P10071 | GLI3 | S877 | psp | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] | Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}. |
| P11831 | SRF | S446 | psp | Serum response factor (SRF) | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}. |
| P16333 | NCK1 | S347 | ochoa | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}. |
| P16871 | IL7R | S366 | ochoa | Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) | Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
| P17252 | PRKCA | S241 | ochoa | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P18583 | SON | S1023 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19086 | GNAZ | S27 | psp | Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. |
| P19544 | WT1 | S393 | psp | Wilms tumor protein (WT33) | Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:17716689, PubMed:25258363, PubMed:7862533). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). {ECO:0000269|PubMed:15520190, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17716689, ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:7862533}. |
| P26358 | DNMT1 | S878 | ochoa|psp | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P27815 | PDE4A | S145 | ochoa|psp | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P28838 | LAP3 | S238 | ochoa | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) | Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}. |
| P30793 | GCH1 | S60 | ochoa | GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) | Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. {ECO:0000269|PubMed:12176133, ECO:0000269|PubMed:16338639, ECO:0000269|PubMed:17057711, ECO:0000269|PubMed:8068008, ECO:0000269|PubMed:9445252}. |
| P31152 | MAPK4 | S386 | ochoa | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| P32519 | ELF1 | S333 | ochoa | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
| P35612 | ADD2 | S532 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P41235 | HNF4A | S313 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P46020 | PHKA1 | S758 | ochoa | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
| P46108 | CRK | S41 | ochoa|psp | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| P46109 | CRKL | S42 | ochoa | Crk-like protein | May mediate the transduction of intracellular signals. |
| P49327 | FASN | S714 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S1509 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49815 | TSC2 | S1420 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P51826 | AFF3 | S393 | ochoa | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. |
| P61587 | RND3 | S210 | psp | Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3) | Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. |
| P63244 | RACK1 | S63 | psp | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
| P78524 | DENND2B | S622 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P80192 | MAP3K9 | S917 | ochoa | Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}. |
| P98171 | ARHGAP4 | S498 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q00872 | MYBPC1 | S906 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q01064 | PDE1B | S466 | ochoa | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) | Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). Has a preference for cGMP as a substrate (PubMed:9419816). {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:8855339, ECO:0000269|PubMed:9419816}. |
| Q03164 | KMT2A | S445 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03169 | TNFAIP2 | S632 | ochoa | Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein) | May play a role as a mediator of inflammation and angiogenesis. |
| Q03188 | CENPC | S528 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q07343 | PDE4B | S133 | ochoa|psp | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}. |
| Q08493 | PDE4C | S119 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (PDE21) (cAMP-specific phosphodiesterase 4C) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:7843419}. |
| Q08499 | PDE4D | S190 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q12802 | AKAP13 | S1565 | ochoa|psp | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12830 | BPTF | S216 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12879 | GRIN2A | S1291 | psp | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:20890276, ECO:0000269|PubMed:23933818, ECO:0000269|PubMed:23933819, ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:24504326, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27288002, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28182669, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:29644724, ECO:0000269|PubMed:36117210, ECO:0000269|PubMed:38307912, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q13009 | TIAM1 | S60 | ochoa|psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13009 | TIAM1 | S172 | ochoa|psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13153 | PAK1 | S21 | psp | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13370 | PDE3B | S495 | ochoa|psp | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13415 | ORC1 | S384 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13427 | PPIG | S687 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13796 | SHROOM2 | S847 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13887 | KLF5 | S116 | ochoa | Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) | Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. |
| Q13936 | CACNA1C | S1981 | psp | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:25260352, ECO:0000269|PubMed:25633834, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:30023270, ECO:0000269|PubMed:30172029, ECO:0000269|PubMed:31430211, ECO:0000269|PubMed:34163037, ECO:0000269|PubMed:8099908, ECO:0000305}.; FUNCTION: [Isoform 12]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 13]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 14]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 15]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 16]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 17]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 18]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:8392192}.; FUNCTION: [Isoform 19]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 20]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 21]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 22]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 23]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 24]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 25]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 26]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 27]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 34]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:11741969}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}. |
| Q13946 | PDE7A | S113 | ochoa | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912). {ECO:0000269|PubMed:19350606, ECO:0000269|PubMed:8389765, ECO:0000269|PubMed:9195912}. |
| Q13950 | RUNX2 | S340 | ochoa|psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14005 | IL16 | S974 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14153 | FAM53B | S118 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
| Q14204 | DYNC1H1 | S4368 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14207 | NPAT | S1348 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14469 | HES1 | S38 | psp | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}. |
| Q14690 | PDCD11 | S926 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14697 | GANAB | S591 | ochoa | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| Q14D04 | VEPH1 | S430 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15390 | MTFR1 | S290 | ochoa | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}. |
| Q15645 | TRIP13 | Y206 | psp | Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13) | Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959). {ECO:0000250|UniProtKB:Q3UA06, ECO:0000269|PubMed:28553959}. |
| Q16822 | PCK2 | S34 | ochoa | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) | Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:28955899). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:28955899). {ECO:0000269|PubMed:28955899}. |
| Q2M1Z3 | ARHGAP31 | S1346 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2PPJ7 | RALGAPA2 | S696 | ochoa|psp | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q2TAL5 | SMTNL2 | S134 | ochoa | Smoothelin-like protein 2 | None |
| Q32M88 | PGGHG | S698 | ochoa | Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1) | Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. {ECO:0000269|PubMed:26682924}. |
| Q3KP66 | INAVA | S246 | ochoa | Innate immunity activator protein | Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}. |
| Q4V9L6 | TMEM119 | S151 | ochoa | Transmembrane protein 119 (Osteoblast induction factor) (OBIF) | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}. |
| Q562F6 | SGO2 | S1085 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q59EK9 | RUNDC3A | S366 | ochoa | RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) | May act as an effector of RAP2A in neuronal cells. {ECO:0000250}. |
| Q5JSZ5 | PRRC2B | S480 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JTW2 | CEP78 | S644 | ochoa | Centrosomal protein of 78 kDa (Cep78) | Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:27246242, PubMed:27588451, PubMed:28242748, PubMed:34259627). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). Involved in cilium biogenesis and controls cilium length (PubMed:27588451). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:28242748, PubMed:34259627). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity). {ECO:0000250|UniProtKB:Q6IRU7, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}. |
| Q5QJE6 | DNTTIP2 | S253 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SYE7 | NHSL1 | S1495 | ochoa | NHS-like protein 1 | None |
| Q5T4S7 | UBR4 | S3860 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T5C0 | STXBP5 | S759 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5VST9 | OBSCN | S125 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VYM1 | SPATA31G1 | S403 | ochoa | Spermatogenesis-associated protein 31G1 | Dispensable for normal development and fertility. {ECO:0000250|UniProtKB:Q3V0E1}. |
| Q5W0B1 | OBI1 | S526 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q63HR2 | TNS2 | S1247 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q66K74 | MAP1S | S939 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68CP9 | ARID2 | S626 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q68EM7 | ARHGAP17 | S840 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6A1A2 | PDPK2P | S214 | ochoa | Putative 3-phosphoinositide-dependent protein kinase 2 (EC 2.7.11.1) (3-phosphoinositide-dependent protein kinase 2 pseudogene) | Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). {ECO:0000250}. |
| Q6BDS2 | BLTP3A | S446 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6GYQ0 | RALGAPA1 | S349 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6NSI3 | FAM53A | S125 | ochoa | Protein FAM53A (Dorsal neural-tube nuclear protein) | May play an important role in neural development; the dorsomedial roof of the third ventricle. {ECO:0000250|UniProtKB:Q5ZKN5}. |
| Q6NW34 | NEPRO | S328 | ochoa | Nucleolus and neural progenitor protein | May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. {ECO:0000250|UniProtKB:Q8R2U2}. |
| Q6P1L5 | FAM117B | S220 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6R327 | RICTOR | S35 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6ZN28 | MACC1 | S139 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q6ZNL6 | FGD5 | S552 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q70EL4 | USP43 | S846 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q70Z35 | PREX2 | S1065 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2) | Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. {ECO:0000269|PubMed:15304342, ECO:0000269|PubMed:15304343, ECO:0000269|PubMed:15897194}. |
| Q71F23 | CENPU | S136 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q71H61 | ILDR2 | S547 | ochoa | Immunoglobulin-like domain-containing receptor 2 (Angulin-3) | May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}. |
| Q765P7 | MTSS2 | S538 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q76M96 | CCDC80 | S434 | psp | Coiled-coil domain-containing protein 80 (Down-regulated by oncogenes protein 1) (Up-regulated in BRS-3 deficient mouse homolog) | Promotes cell adhesion and matrix assembly. {ECO:0000250}. |
| Q7KZI7 | MARK2 | S631 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7RTP6 | MICAL3 | S1792 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2Z1 | TICRR | S865 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z5K2 | WAPL | S347 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6Z7 | HUWE1 | S2887 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86T13 | CLEC14A | S437 | ochoa | C-type lectin domain family 14 member A (Epidermal growth factor receptor 5) (EGFR-5) | None |
| Q86T82 | USP37 | S210 | ochoa | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) | Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517). {ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:26299517, ECO:0000269|PubMed:27296872, ECO:0000269|PubMed:31911859, ECO:0000269|PubMed:34509474, ECO:0000269|PubMed:34606619}. |
| Q86T90 | KIAA1328 | S229 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86UW6 | N4BP2 | S607 | ochoa | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q86WR7 | PROSER2 | S400 | ochoa | Proline and serine-rich protein 2 | None |
| Q86XZ4 | SPATS2 | S386 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IUD6 | RNF135 | S159 | ochoa | E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135) | E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531). {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:21147464, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531, ECO:0000305|PubMed:31006531}. |
| Q8IUG5 | MYO18B | S2170 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IW93 | ARHGEF19 | S101 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IY18 | SMC5 | S35 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8IY57 | YAF2 | S57 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8IZP0 | ABI1 | S231 | ochoa | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8IZQ1 | WDFY3 | S3335 | ochoa | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}. |
| Q8N108 | MIER1 | S483 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
| Q8N1Q1 | CA13 | S49 | ochoa | Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII) | Reversible hydration of carbon dioxide. |
| Q8N1W1 | ARHGEF28 | S478 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
| Q8N1W1 | ARHGEF28 | S624 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
| Q8N3C7 | CLIP4 | S581 | ochoa | CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) | None |
| Q8N3K9 | CMYA5 | S1708 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N4Y2 | CRACR2B | S307 | ochoa | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}. |
| Q8N573 | OXR1 | S91 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5F7 | NKAP | S80 | ochoa | NF-kappa-B-activating protein | Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}. |
| Q8N8U9 | BMPER | S414 | ochoa | BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2) | Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. {ECO:0000269|PubMed:14766204}. |
| Q8N9B5 | JMY | S58 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NCN4 | RNF169 | S339 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NEV8 | EXPH5 | S1851 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NEY1 | NAV1 | S1048 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S113 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NHY2 | COP1 | S387 | psp | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). {ECO:0000269|PubMed:12466024, ECO:0000269|PubMed:12615916, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15103385, ECO:0000269|PubMed:19805145, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21625211, ECO:0000303|PubMed:27041596}. |
| Q8NI35 | PATJ | S1618 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TBE0 | BAHD1 | S121 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TCU6 | PREX1 | S1195 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TDW5 | SYTL5 | S211 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TDW5 | SYTL5 | S306 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TEV9 | SMCR8 | S643 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8TF01 | PNISR | S726 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8TF72 | SHROOM3 | S1242 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WU20 | FRS2 | S155 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WUI4 | HDAC7 | S181 | ochoa|psp | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WWI1 | LMO7 | S805 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWL2 | SPIRE2 | S476 | ochoa | Protein spire homolog 2 (Spir-2) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q8K1S6, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480}. |
| Q92618 | ZNF516 | S1121 | ochoa | Zinc finger protein 516 | Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). {ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}. |
| Q92794 | KAT6A | S1861 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q92833 | JARID2 | S821 | ochoa | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q92835 | INPP5D | S1085 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q92859 | NEO1 | S1299 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q92974 | ARHGEF2 | S886 | ochoa|psp | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q96B18 | DACT3 | S188 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96B97 | SH3KBP1 | S587 | ochoa|psp | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96DR7 | ARHGEF26 | S22 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96DR7 | ARHGEF26 | S222 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96EX2 | RNFT2 | S19 | ochoa | E3 ubiquitin-protein ligase RNFT2 (RING finger and transmembrane domain-containing protein 2) (Transmembrane protein 118) | E3 ubiquitin-protein ligase that negatively regulates IL3-dependent cellular responses through IL3RA ubiquitination and degradation by the proteasome, having an anti-inflammatory effect. {ECO:0000269|PubMed:31990690}. |
| Q96JH7 | VCPIP1 | S46 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
| Q96JH7 | VCPIP1 | S1128 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
| Q96K30 | RITA1 | S199 | ochoa | RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein) | Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}. |
| Q96K83 | ZNF521 | S546 | ochoa | Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}. |
| Q96LR2 | LURAP1 | S126 | ochoa | Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A) | Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250|UniProtKB:D4A8G3, ECO:0000269|PubMed:21048106}. |
| Q96Q42 | ALS2 | S353 | ochoa | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q96QB1 | DLC1 | S868 | psp | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96RL1 | UIMC1 | S627 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99490 | AGAP2 | S927 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99996 | AKAP9 | S43 | psp | A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) | Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}. |
| Q9BRR9 | ARHGAP9 | S144 | ochoa | Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}. |
| Q9BVI0 | PHF20 | S291 | psp | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BW19 | KIFC1 | S71 | psp | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}. |
| Q9BX63 | BRIP1 | S990 | ochoa|psp | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXC1 | GPR174 | S304 | ochoa | Probable G-protein coupled receptor 174 | G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:36823105). Plays a negative role in regulatory T-cell accumulation and homeostasis. Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response. Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells. Mechanistically, acts via G(s)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling. Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions. Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells. Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells. {ECO:0000250|UniProtKB:Q3U507, ECO:0000269|PubMed:36823105}. |
| Q9BY89 | KIAA1671 | S589 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BY89 | KIAA1671 | S1574 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZ95 | NSD3 | S424 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9BZS1 | FOXP3 | S270 | psp | Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}. |
| Q9C0D6 | FHDC1 | S949 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9C0H5 | ARHGAP39 | S190 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H2F5 | EPC1 | S535 | ochoa | Enhancer of polycomb homolog 1 | Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
| Q9H582 | ZNF644 | S673 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H6L5 | RETREG1 | S151 | ochoa|psp | Reticulophagy regulator 1 (Reticulophagy receptor 1) | Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720). {ECO:0000250|UniProtKB:Q8VE91, ECO:0000269|PubMed:19838196, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:34338405}.; FUNCTION: (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:35239449}. |
| Q9H8V3 | ECT2 | S880 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9H9J4 | USP42 | S1263 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HC98 | NEK6 | S198 | ochoa | Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). {ECO:0000269|PubMed:11516946, ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361, ECO:0000269|PubMed:31409757}. |
| Q9NPI6 | DCP1A | S522 | ochoa|psp | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NR48 | ASH1L | S1226 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRA8 | EIF4ENIF1 | S213 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRH2 | SNRK | S570 | ochoa | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}. |
| Q9NSK0 | KLC4 | S566 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NSY1 | BMP2K | S826 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NUQ6 | SPATS2L | S392 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NVW2 | RLIM | S164 | ochoa | E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Q9NWQ8 | PAG1 | S50 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NYB9 | ABI2 | S233 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9NYF3 | FAM53C | S122 | ochoa | Protein FAM53C | None |
| Q9NYJ8 | TAB2 | S423 | psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}. |
| Q9P0L2 | MARK1 | S649 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9P1Y6 | PHRF1 | S864 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P206 | NHSL3 | S929 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P270 | SLAIN2 | S435 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2M4 | TBC1D14 | S128 | ochoa | TBC1 domain family member 14 | Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}. |
| Q9P2N2 | ARHGAP28 | S55 | ochoa | Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UBB9 | TFIP11 | S283 | ochoa | Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) | Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}. |
| Q9UBD5 | ORC3 | S23 | ochoa | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:31160578}. |
| Q9UBF8 | PI4KB | S294 | psp | Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}. |
| Q9UGL1 | KDM5B | S1456 | ochoa|psp | Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}. |
| Q9UGU0 | TCF20 | S1259 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UH92 | MLX | S98 | ochoa | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Q9UHB6 | LIMA1 | S225 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB7 | AFF4 | S212 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UJ78 | ZMYM5 | S560 | ochoa | Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) | Functions as a transcriptional regulator. {ECO:0000269|PubMed:17126306}. |
| Q9UJA3 | MCM8 | S630 | ochoa | DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093). {ECO:0000250|UniProtKB:Q9CWV1, ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}. |
| Q9UKG1 | APPL1 | S410 | ochoa|psp | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
| Q9ULH0 | KIDINS220 | S918 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULJ3 | ZBTB21 | S345 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULL1 | PLEKHG1 | S695 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULL1 | PLEKHG1 | S1183 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULL8 | SHROOM4 | S378 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9ULV3 | CIZ1 | S198 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9ULV3 | CIZ1 | S868 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UMZ2 | SYNRG | S752 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPQ3 | AGAP1 | S605 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1) | GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. |
| Q9UQ35 | SRRM2 | S248 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB8 | BAIAP2 | S492 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y216 | MTMR7 | S595 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR7 (EC 3.1.3.64) (Inositol 1,3-bisphosphate phosphatase) (Myotubularin-related protein 7) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2). {ECO:0000250|UniProtKB:Q9Z2C9}. |
| Q9Y2I7 | PIKFYVE | S1549 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y3M8 | STARD13 | S589 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y3S1 | WNK2 | S1889 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y4F5 | CEP170B | S619 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y616 | IRAK3 | S467 | ochoa | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}. |
| O14974 | PPP1R12A | Y669 | Sugiyama | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| Q9UNE7 | STUB1 | S149 | Sugiyama | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) | E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (By similarity). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). Plays a role in the degradation of TP53 (PubMed:26634371). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity). {ECO:0000250|UniProtKB:A6HD62, ECO:0000250|UniProtKB:Q9WUD1, ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30980393}. |
| P35368 | ADRA1B | S406 | SIGNOR|iPTMNet|EPSD | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P55199 | ELL | S47 | Sugiyama | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
| Q9NVX2 | NLE1 | S331 | Sugiyama | Notchless protein homolog 1 | Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). {ECO:0000250}. |
| Q9BTC0 | DIDO1 | S988 | Sugiyama | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q12913 | PTPRJ | S303 | Sugiyama | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:30591527, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}. |
| Q27J81 | INF2 | S855 | Sugiyama | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q9BUP3 | HTATIP2 | S177 | Sugiyama | Protein HTATIP2 (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2) | Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672). {ECO:0000250|UniProtKB:B0BNF8, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:18519672}. |
| Q9UK23 | NAGPA | S145 | Sugiyama | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) | Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. {ECO:0000269|PubMed:23572527}. |
| Q9Y262 | EIF3L | S81 | Sugiyama | Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q13111 | CHAF1A | S777 | Sugiyama | Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250|UniProtKB:Q5R1T0}. |
| O43175 | PHGDH | S166 | Sugiyama | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-193648 | NRAGE signals death through JNK | 0.000004 | 5.375 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.000006 | 5.188 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.000027 | 4.573 |
| R-HSA-73887 | Death Receptor Signaling | 0.000116 | 3.936 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.000187 | 3.729 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.000263 | 3.580 |
| R-HSA-194138 | Signaling by VEGF | 0.000354 | 3.451 |
| R-HSA-162582 | Signal Transduction | 0.000404 | 3.393 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.000489 | 3.310 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.000491 | 3.309 |
| R-HSA-169893 | Prolonged ERK activation events | 0.000588 | 3.231 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.000687 | 3.163 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.001387 | 2.858 |
| R-HSA-186712 | Regulation of beta-cell development | 0.001769 | 2.752 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.002033 | 2.692 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.002415 | 2.617 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.002464 | 2.608 |
| R-HSA-428540 | Activation of RAC1 | 0.002930 | 2.533 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.003323 | 2.479 |
| R-HSA-180024 | DARPP-32 events | 0.004436 | 2.353 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.004605 | 2.337 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.004436 | 2.353 |
| R-HSA-186763 | Downstream signal transduction | 0.005383 | 2.269 |
| R-HSA-1640170 | Cell Cycle | 0.005480 | 2.261 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.005784 | 2.238 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.007777 | 2.109 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.008937 | 2.049 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.008937 | 2.049 |
| R-HSA-3928664 | Ephrin signaling | 0.009475 | 2.023 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.008185 | 2.087 |
| R-HSA-68877 | Mitotic Prometaphase | 0.007077 | 2.150 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.008098 | 2.092 |
| R-HSA-202403 | TCR signaling | 0.008537 | 2.069 |
| R-HSA-187687 | Signalling to ERKs | 0.008318 | 2.080 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.008890 | 2.051 |
| R-HSA-9831926 | Nephron development | 0.009475 | 2.023 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.009450 | 2.025 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.009450 | 2.025 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.009450 | 2.025 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.009450 | 2.025 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.009450 | 2.025 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.010620 | 1.974 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.011303 | 1.947 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.013023 | 1.885 |
| R-HSA-4839726 | Chromatin organization | 0.013145 | 1.881 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.013187 | 1.880 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.014197 | 1.848 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.015004 | 1.824 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.015978 | 1.796 |
| R-HSA-8875656 | MET receptor recycling | 0.018293 | 1.738 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.016944 | 1.771 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.017514 | 1.757 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.018293 | 1.738 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.018740 | 1.727 |
| R-HSA-170984 | ARMS-mediated activation | 0.021508 | 1.667 |
| R-HSA-111885 | Opioid Signalling | 0.021820 | 1.661 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.021467 | 1.668 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.024938 | 1.603 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.024938 | 1.603 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.025226 | 1.598 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.025226 | 1.598 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.028575 | 1.544 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.030501 | 1.516 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.030028 | 1.522 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.036577 | 1.437 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.041299 | 1.384 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.045017 | 1.347 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.045017 | 1.347 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.040638 | 1.391 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.045016 | 1.347 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.036434 | 1.438 |
| R-HSA-170968 | Frs2-mediated activation | 0.040638 | 1.391 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.044712 | 1.350 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.042934 | 1.367 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.040638 | 1.391 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.036434 | 1.438 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.037257 | 1.429 |
| R-HSA-69275 | G2/M Transition | 0.040040 | 1.398 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.041962 | 1.377 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.045016 | 1.347 |
| R-HSA-186797 | Signaling by PDGF | 0.043136 | 1.365 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.047349 | 1.325 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.049559 | 1.305 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.049559 | 1.305 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.054362 | 1.265 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.054362 | 1.265 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.105778 | 0.976 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.105778 | 0.976 |
| R-HSA-111957 | Cam-PDE 1 activation | 0.138498 | 0.859 |
| R-HSA-109703 | PKB-mediated events | 0.138498 | 0.859 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.138498 | 0.859 |
| R-HSA-165160 | PDE3B signalling | 0.138498 | 0.859 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.138498 | 0.859 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.170024 | 0.769 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.170024 | 0.769 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.170024 | 0.769 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.059111 | 1.228 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.185353 | 0.732 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.200400 | 0.698 |
| R-HSA-9613354 | Lipophagy | 0.200400 | 0.698 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.215170 | 0.667 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.229669 | 0.639 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.243900 | 0.613 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.243900 | 0.613 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.126664 | 0.897 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.126664 | 0.897 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.132894 | 0.876 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.132894 | 0.876 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.050933 | 1.293 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.298252 | 0.525 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.298252 | 0.525 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.102858 | 0.988 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.102858 | 0.988 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.066305 | 1.178 |
| R-HSA-380287 | Centrosome maturation | 0.071093 | 1.148 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.184816 | 0.733 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.323949 | 0.490 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.191505 | 0.718 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.211746 | 0.674 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.218541 | 0.660 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.218541 | 0.660 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.360747 | 0.443 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.360747 | 0.443 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.109272 | 0.961 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.372564 | 0.429 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.372564 | 0.429 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.372564 | 0.429 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.372564 | 0.429 |
| R-HSA-774815 | Nucleosome assembly | 0.259596 | 0.586 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.259596 | 0.586 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.395549 | 0.403 |
| R-HSA-72649 | Translation initiation complex formation | 0.321183 | 0.493 |
| R-HSA-418597 | G alpha (z) signalling events | 0.327968 | 0.484 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.334735 | 0.475 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.364907 | 0.438 |
| R-HSA-72172 | mRNA Splicing | 0.405180 | 0.392 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.243900 | 0.613 |
| R-HSA-111458 | Formation of apoptosome | 0.215170 | 0.667 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.115352 | 0.938 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.243900 | 0.613 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.323949 | 0.490 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.064106 | 1.193 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.360747 | 0.443 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.372564 | 0.429 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.406724 | 0.391 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.215170 | 0.667 |
| R-HSA-109704 | PI3K Cascade | 0.095368 | 1.021 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.261138 | 0.583 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.395549 | 0.403 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.395549 | 0.403 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.406724 | 0.391 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.105778 | 0.976 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.138498 | 0.859 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.323949 | 0.490 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.164976 | 0.783 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.257869 | 0.589 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.105778 | 0.976 |
| R-HSA-165158 | Activation of AKT2 | 0.122290 | 0.913 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.285040 | 0.545 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.348708 | 0.458 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.273325 | 0.563 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.106689 | 0.972 |
| R-HSA-202424 | Downstream TCR signaling | 0.281159 | 0.551 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.392046 | 0.407 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.398696 | 0.399 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.122290 | 0.913 |
| R-HSA-6798695 | Neutrophil degranulation | 0.399900 | 0.398 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.321535 | 0.493 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.225354 | 0.647 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.301312 | 0.521 |
| R-HSA-112399 | IRS-mediated signalling | 0.122548 | 0.912 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.204697 | 0.689 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.323949 | 0.490 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.321535 | 0.493 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.061642 | 1.210 |
| R-HSA-167169 | HIV Transcription Elongation | 0.218541 | 0.660 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.071820 | 1.144 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.088957 | 1.051 |
| R-HSA-8866376 | Reelin signalling pathway | 0.122290 | 0.913 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.122290 | 0.913 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.154407 | 0.811 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.154407 | 0.811 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.054260 | 1.266 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.170024 | 0.769 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.200400 | 0.698 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.243900 | 0.613 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.298252 | 0.525 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.298252 | 0.525 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.075565 | 1.122 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.075565 | 1.122 |
| R-HSA-9664407 | Parasite infection | 0.075565 | 1.122 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.348708 | 0.458 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.285040 | 0.545 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.164976 | 0.783 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.348708 | 0.458 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.122548 | 0.912 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.126664 | 0.897 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.144848 | 0.839 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.185353 | 0.732 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.126664 | 0.897 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.164976 | 0.783 |
| R-HSA-8875878 | MET promotes cell motility | 0.204973 | 0.688 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.139204 | 0.856 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.348708 | 0.458 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.197823 | 0.704 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.200400 | 0.698 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.126664 | 0.897 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.298252 | 0.525 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.164976 | 0.783 |
| R-HSA-69541 | Stabilization of p53 | 0.211746 | 0.674 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.193112 | 0.714 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.071717 | 1.144 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.200400 | 0.698 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.348708 | 0.458 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.056134 | 1.251 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.120507 | 0.919 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.122290 | 0.913 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.185353 | 0.732 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.215170 | 0.667 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.229669 | 0.639 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.229669 | 0.639 |
| R-HSA-1483226 | Synthesis of PI | 0.229669 | 0.639 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.243900 | 0.613 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.114428 | 0.941 |
| R-HSA-8963901 | Chylomicron remodeling | 0.271581 | 0.566 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.323949 | 0.490 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.336444 | 0.473 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.348708 | 0.458 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.348708 | 0.458 |
| R-HSA-9646399 | Aggrephagy | 0.218541 | 0.660 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.384163 | 0.415 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.266460 | 0.574 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.348207 | 0.458 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.321535 | 0.493 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.351871 | 0.454 |
| R-HSA-373752 | Netrin-1 signaling | 0.074349 | 1.129 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.152169 | 0.818 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.074497 | 1.128 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.323949 | 0.490 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.327968 | 0.484 |
| R-HSA-983189 | Kinesins | 0.361588 | 0.442 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.287044 | 0.542 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.287044 | 0.542 |
| R-HSA-3214847 | HATs acetylate histones | 0.336712 | 0.473 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.088113 | 1.055 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.156573 | 0.805 |
| R-HSA-68886 | M Phase | 0.135714 | 0.867 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.105778 | 0.976 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.122290 | 0.913 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.170024 | 0.769 |
| R-HSA-390696 | Adrenoceptors | 0.185353 | 0.732 |
| R-HSA-444257 | RSK activation | 0.185353 | 0.732 |
| R-HSA-176974 | Unwinding of DNA | 0.200400 | 0.698 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.079880 | 1.098 |
| R-HSA-9683686 | Maturation of spike protein | 0.215170 | 0.667 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.271581 | 0.566 |
| R-HSA-418457 | cGMP effects | 0.285040 | 0.545 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.298252 | 0.525 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.298252 | 0.525 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.298252 | 0.525 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.395549 | 0.403 |
| R-HSA-163685 | Integration of energy metabolism | 0.159381 | 0.798 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.251199 | 0.600 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.233258 | 0.632 |
| R-HSA-3214842 | HDMs demethylate histones | 0.114428 | 0.941 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.120507 | 0.919 |
| R-HSA-388396 | GPCR downstream signalling | 0.070201 | 1.154 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.200400 | 0.698 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.360747 | 0.443 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.334735 | 0.475 |
| R-HSA-9612973 | Autophagy | 0.407026 | 0.390 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.088113 | 1.055 |
| R-HSA-74160 | Gene expression (Transcription) | 0.269259 | 0.570 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.126664 | 0.897 |
| R-HSA-69481 | G2/M Checkpoints | 0.128214 | 0.892 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.226483 | 0.645 |
| R-HSA-422475 | Axon guidance | 0.110992 | 0.955 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.149693 | 0.825 |
| R-HSA-199991 | Membrane Trafficking | 0.366929 | 0.435 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.138498 | 0.859 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.229669 | 0.639 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.257869 | 0.589 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.257869 | 0.589 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.257869 | 0.589 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.271581 | 0.566 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.311220 | 0.507 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.152169 | 0.818 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.395549 | 0.403 |
| R-HSA-177929 | Signaling by EGFR | 0.334735 | 0.475 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.354910 | 0.450 |
| R-HSA-6806834 | Signaling by MET | 0.083811 | 1.077 |
| R-HSA-212436 | Generic Transcription Pathway | 0.116030 | 0.935 |
| R-HSA-9675108 | Nervous system development | 0.159404 | 0.798 |
| R-HSA-69239 | Synthesis of DNA | 0.382050 | 0.418 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.406962 | 0.390 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.298252 | 0.525 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.336444 | 0.473 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.381461 | 0.419 |
| R-HSA-418555 | G alpha (s) signalling events | 0.067236 | 1.172 |
| R-HSA-9663891 | Selective autophagy | 0.271128 | 0.567 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.218541 | 0.660 |
| R-HSA-202433 | Generation of second messenger molecules | 0.218541 | 0.660 |
| R-HSA-449836 | Other interleukin signaling | 0.360747 | 0.443 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.130923 | 0.883 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.361957 | 0.441 |
| R-HSA-111933 | Calmodulin induced events | 0.191505 | 0.718 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.204973 | 0.688 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.271581 | 0.566 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.298252 | 0.525 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.323949 | 0.490 |
| R-HSA-111997 | CaM pathway | 0.191505 | 0.718 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.401068 | 0.397 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.397870 | 0.400 |
| R-HSA-69206 | G1/S Transition | 0.265411 | 0.576 |
| R-HSA-69242 | S Phase | 0.373608 | 0.428 |
| R-HSA-166520 | Signaling by NTRKs | 0.092480 | 1.034 |
| R-HSA-1632852 | Macroautophagy | 0.340059 | 0.468 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.117936 | 0.928 |
| R-HSA-373753 | Nephrin family interactions | 0.079880 | 1.098 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.395549 | 0.403 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.314381 | 0.503 |
| R-HSA-111996 | Ca-dependent events | 0.239024 | 0.622 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.372366 | 0.429 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.330360 | 0.481 |
| R-HSA-9658195 | Leishmania infection | 0.330360 | 0.481 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.296265 | 0.528 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.236405 | 0.626 |
| R-HSA-1483255 | PI Metabolism | 0.161742 | 0.791 |
| R-HSA-447043 | Neurofascin interactions | 0.154407 | 0.811 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.200400 | 0.698 |
| R-HSA-210990 | PECAM1 interactions | 0.229669 | 0.639 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.298252 | 0.525 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.164976 | 0.783 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.198225 | 0.703 |
| R-HSA-8854214 | TBC/RABGAPs | 0.245875 | 0.609 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.259596 | 0.586 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.229308 | 0.640 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.145554 | 0.837 |
| R-HSA-1280218 | Adaptive Immune System | 0.342717 | 0.465 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.285040 | 0.545 |
| R-HSA-977347 | Serine metabolism | 0.395549 | 0.403 |
| R-HSA-112043 | PLC beta mediated events | 0.368240 | 0.434 |
| R-HSA-75893 | TNF signaling | 0.118505 | 0.926 |
| R-HSA-5357801 | Programmed Cell Death | 0.244580 | 0.612 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.054260 | 1.266 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.085381 | 1.069 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.257869 | 0.589 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.311220 | 0.507 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.323949 | 0.490 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.143483 | 0.843 |
| R-HSA-372790 | Signaling by GPCR | 0.146436 | 0.834 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.266128 | 0.575 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.079207 | 1.101 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.199332 | 0.700 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.212116 | 0.673 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.365224 | 0.437 |
| R-HSA-201556 | Signaling by ALK | 0.211746 | 0.674 |
| R-HSA-68882 | Mitotic Anaphase | 0.154478 | 0.811 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.178163 | 0.749 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.348708 | 0.458 |
| R-HSA-180292 | GAB1 signalosome | 0.348708 | 0.458 |
| R-HSA-445144 | Signal transduction by L1 | 0.372564 | 0.429 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.156789 | 0.805 |
| R-HSA-5688426 | Deubiquitination | 0.405841 | 0.392 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.055707 | 1.254 |
| R-HSA-354192 | Integrin signaling | 0.164976 | 0.783 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.311220 | 0.507 |
| R-HSA-8853659 | RET signaling | 0.191505 | 0.718 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.327968 | 0.484 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.067859 | 1.168 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.334735 | 0.475 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.120507 | 0.919 |
| R-HSA-9733709 | Cardiogenesis | 0.164976 | 0.783 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.259596 | 0.586 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.266460 | 0.574 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.191505 | 0.718 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.406724 | 0.391 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.406724 | 0.391 |
| R-HSA-9830369 | Kidney development | 0.165499 | 0.781 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.326594 | 0.486 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.164976 | 0.783 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.381461 | 0.419 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.361588 | 0.442 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.286188 | 0.543 |
| R-HSA-112040 | G-protein mediated events | 0.407540 | 0.390 |
| R-HSA-167172 | Transcription of the HIV genome | 0.413977 | 0.383 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.413977 | 0.383 |
| R-HSA-5218859 | Regulated Necrosis | 0.413977 | 0.383 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.413977 | 0.383 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.416846 | 0.380 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.417694 | 0.379 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.417694 | 0.379 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.417694 | 0.379 |
| R-HSA-3000170 | Syndecan interactions | 0.417694 | 0.379 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.420379 | 0.376 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.428461 | 0.368 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.428461 | 0.368 |
| R-HSA-429947 | Deadenylation of mRNA | 0.428461 | 0.368 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.428461 | 0.368 |
| R-HSA-109581 | Apoptosis | 0.431867 | 0.365 |
| R-HSA-1266738 | Developmental Biology | 0.432877 | 0.364 |
| R-HSA-1500931 | Cell-Cell communication | 0.435769 | 0.361 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.439031 | 0.358 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.439031 | 0.358 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.439031 | 0.358 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.439031 | 0.358 |
| R-HSA-420029 | Tight junction interactions | 0.439031 | 0.358 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.439031 | 0.358 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.439031 | 0.358 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.439031 | 0.358 |
| R-HSA-9620244 | Long-term potentiation | 0.439031 | 0.358 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.439031 | 0.358 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.439368 | 0.357 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.445622 | 0.351 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.449405 | 0.347 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.449405 | 0.347 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.449405 | 0.347 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.449405 | 0.347 |
| R-HSA-70635 | Urea cycle | 0.449405 | 0.347 |
| R-HSA-525793 | Myogenesis | 0.449405 | 0.347 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.451838 | 0.345 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.451838 | 0.345 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.451838 | 0.345 |
| R-HSA-68875 | Mitotic Prophase | 0.455803 | 0.341 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.458013 | 0.339 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.459588 | 0.338 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.459588 | 0.338 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.469583 | 0.328 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.469583 | 0.328 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.469583 | 0.328 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.470134 | 0.328 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.470134 | 0.328 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.476295 | 0.322 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.476295 | 0.322 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.479394 | 0.319 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.479394 | 0.319 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.479394 | 0.319 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.479394 | 0.319 |
| R-HSA-5334118 | DNA methylation | 0.479394 | 0.319 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.479394 | 0.319 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.479394 | 0.319 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.479394 | 0.319 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.480223 | 0.319 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.482306 | 0.317 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.484016 | 0.315 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.488274 | 0.311 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.489024 | 0.311 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.489024 | 0.311 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.489024 | 0.311 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.489024 | 0.311 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.489024 | 0.311 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.489024 | 0.311 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.489024 | 0.311 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.489024 | 0.311 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.491460 | 0.309 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.494199 | 0.306 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.498477 | 0.302 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.498477 | 0.302 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.498477 | 0.302 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.498477 | 0.302 |
| R-HSA-182971 | EGFR downregulation | 0.498477 | 0.302 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.507755 | 0.294 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.507755 | 0.294 |
| R-HSA-69190 | DNA strand elongation | 0.507755 | 0.294 |
| R-HSA-9843745 | Adipogenesis | 0.516610 | 0.287 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.516862 | 0.287 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.516862 | 0.287 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.516862 | 0.287 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.516862 | 0.287 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.516862 | 0.287 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.516862 | 0.287 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.516862 | 0.287 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.516862 | 0.287 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.516862 | 0.287 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.523163 | 0.281 |
| R-HSA-390522 | Striated Muscle Contraction | 0.525802 | 0.279 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.525802 | 0.279 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.525802 | 0.279 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.525802 | 0.279 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.525802 | 0.279 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.525802 | 0.279 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.525802 | 0.279 |
| R-HSA-157118 | Signaling by NOTCH | 0.532929 | 0.273 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.534576 | 0.272 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.534576 | 0.272 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.534576 | 0.272 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.534576 | 0.272 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.534576 | 0.272 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.534576 | 0.272 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.534576 | 0.272 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.534576 | 0.272 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.543189 | 0.265 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.543189 | 0.265 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.543189 | 0.265 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.543189 | 0.265 |
| R-HSA-5617833 | Cilium Assembly | 0.546659 | 0.262 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.551643 | 0.258 |
| R-HSA-163560 | Triglyceride catabolism | 0.551643 | 0.258 |
| R-HSA-6807070 | PTEN Regulation | 0.556510 | 0.255 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.559940 | 0.252 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.559940 | 0.252 |
| R-HSA-419037 | NCAM1 interactions | 0.559940 | 0.252 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.559940 | 0.252 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.568085 | 0.246 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.568085 | 0.246 |
| R-HSA-9609690 | HCMV Early Events | 0.568916 | 0.245 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.572427 | 0.242 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.573602 | 0.241 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.573602 | 0.241 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.576080 | 0.240 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.576080 | 0.240 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.576080 | 0.240 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.583927 | 0.234 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.583927 | 0.234 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.583927 | 0.234 |
| R-HSA-5260271 | Diseases of Immune System | 0.583927 | 0.234 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.583927 | 0.234 |
| R-HSA-8982491 | Glycogen metabolism | 0.583927 | 0.234 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.583927 | 0.234 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.585725 | 0.232 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.588009 | 0.231 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.591629 | 0.228 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.591629 | 0.228 |
| R-HSA-9694548 | Maturation of spike protein | 0.591629 | 0.228 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.591629 | 0.228 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.591629 | 0.228 |
| R-HSA-9607240 | FLT3 Signaling | 0.591629 | 0.228 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.593109 | 0.227 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.594383 | 0.226 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.598161 | 0.223 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.598460 | 0.223 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.599189 | 0.222 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.599189 | 0.222 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.599189 | 0.222 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.599189 | 0.222 |
| R-HSA-422356 | Regulation of insulin secretion | 0.603167 | 0.220 |
| R-HSA-165159 | MTOR signalling | 0.606610 | 0.217 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.613893 | 0.212 |
| R-HSA-9710421 | Defective pyroptosis | 0.613893 | 0.212 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.613893 | 0.212 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.613893 | 0.212 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.614499 | 0.211 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.617018 | 0.210 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.617901 | 0.209 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.617901 | 0.209 |
| R-HSA-69306 | DNA Replication | 0.618441 | 0.209 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.621042 | 0.207 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.621042 | 0.207 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.621042 | 0.207 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.628060 | 0.202 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.628060 | 0.202 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.628060 | 0.202 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.628534 | 0.202 |
| R-HSA-397014 | Muscle contraction | 0.628534 | 0.202 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.632212 | 0.199 |
| R-HSA-162587 | HIV Life Cycle | 0.633935 | 0.198 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.634948 | 0.197 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.634948 | 0.197 |
| R-HSA-9675135 | Diseases of DNA repair | 0.634948 | 0.197 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.634948 | 0.197 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.636888 | 0.196 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.636888 | 0.196 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.641518 | 0.193 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.641708 | 0.193 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.641708 | 0.193 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.645267 | 0.190 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.646102 | 0.190 |
| R-HSA-5620924 | Intraflagellar transport | 0.648344 | 0.188 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.648344 | 0.188 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.648344 | 0.188 |
| R-HSA-9634597 | GPER1 signaling | 0.648344 | 0.188 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.648344 | 0.188 |
| R-HSA-70263 | Gluconeogenesis | 0.648344 | 0.188 |
| R-HSA-446728 | Cell junction organization | 0.652718 | 0.185 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.654857 | 0.184 |
| R-HSA-9766229 | Degradation of CDH1 | 0.654857 | 0.184 |
| R-HSA-73893 | DNA Damage Bypass | 0.654857 | 0.184 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.655130 | 0.184 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.655130 | 0.184 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.655130 | 0.184 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.659575 | 0.181 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.661251 | 0.180 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.663974 | 0.178 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.663974 | 0.178 |
| R-HSA-2514856 | The phototransduction cascade | 0.667526 | 0.176 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.673685 | 0.172 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.673685 | 0.172 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.673685 | 0.172 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.676898 | 0.169 |
| R-HSA-1221632 | Meiotic synapsis | 0.679730 | 0.168 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.679730 | 0.168 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.680855 | 0.167 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.681115 | 0.167 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.683766 | 0.165 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.685852 | 0.164 |
| R-HSA-418594 | G alpha (i) signalling events | 0.686671 | 0.163 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.688097 | 0.162 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.689415 | 0.162 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.691489 | 0.160 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.694847 | 0.158 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.694847 | 0.158 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.694847 | 0.158 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.697205 | 0.157 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.697537 | 0.156 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.697537 | 0.156 |
| R-HSA-373760 | L1CAM interactions | 0.697537 | 0.156 |
| R-HSA-1483257 | Phospholipid metabolism | 0.699532 | 0.155 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.701486 | 0.154 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.701486 | 0.154 |
| R-HSA-70326 | Glucose metabolism | 0.701532 | 0.154 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.702816 | 0.153 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.702816 | 0.153 |
| R-HSA-5693538 | Homology Directed Repair | 0.705482 | 0.152 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.708324 | 0.150 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.709390 | 0.149 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.709390 | 0.149 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.713730 | 0.146 |
| R-HSA-191859 | snRNP Assembly | 0.713730 | 0.146 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.713730 | 0.146 |
| R-HSA-8979227 | Triglyceride metabolism | 0.713730 | 0.146 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.713730 | 0.146 |
| R-HSA-73886 | Chromosome Maintenance | 0.717075 | 0.144 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.719036 | 0.143 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.719036 | 0.143 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.719395 | 0.143 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.720853 | 0.142 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.720853 | 0.142 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.724243 | 0.140 |
| R-HSA-450294 | MAP kinase activation | 0.724243 | 0.140 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.728283 | 0.138 |
| R-HSA-9707616 | Heme signaling | 0.729355 | 0.137 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.729355 | 0.137 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.729355 | 0.137 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.729355 | 0.137 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.734372 | 0.134 |
| R-HSA-373755 | Semaphorin interactions | 0.734372 | 0.134 |
| R-HSA-8848021 | Signaling by PTK6 | 0.734372 | 0.134 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.734372 | 0.134 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.735545 | 0.133 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.735545 | 0.133 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.735545 | 0.133 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.739297 | 0.131 |
| R-HSA-9609646 | HCMV Infection | 0.741555 | 0.130 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.744130 | 0.128 |
| R-HSA-421270 | Cell-cell junction organization | 0.744142 | 0.128 |
| R-HSA-9679506 | SARS-CoV Infections | 0.747987 | 0.126 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.750684 | 0.125 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.753531 | 0.123 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.753531 | 0.123 |
| R-HSA-5576891 | Cardiac conduction | 0.759673 | 0.119 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.760157 | 0.119 |
| R-HSA-9909396 | Circadian clock | 0.762960 | 0.117 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.764664 | 0.117 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.766991 | 0.115 |
| R-HSA-448424 | Interleukin-17 signaling | 0.766991 | 0.115 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.766991 | 0.115 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.766991 | 0.115 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.771312 | 0.113 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.771312 | 0.113 |
| R-HSA-8978934 | Metabolism of cofactors | 0.771312 | 0.113 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.771312 | 0.113 |
| R-HSA-168249 | Innate Immune System | 0.772882 | 0.112 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.775554 | 0.110 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.775554 | 0.110 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.779717 | 0.108 |
| R-HSA-4086398 | Ca2+ pathway | 0.779717 | 0.108 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.780594 | 0.108 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.783162 | 0.106 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.783804 | 0.106 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.787815 | 0.104 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.787815 | 0.104 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.787815 | 0.104 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.795615 | 0.099 |
| R-HSA-4086400 | PCP/CE pathway | 0.799407 | 0.097 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.802267 | 0.096 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.805038 | 0.094 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.806783 | 0.093 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.806783 | 0.093 |
| R-HSA-9833482 | PKR-mediated signaling | 0.806783 | 0.093 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.810369 | 0.091 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.810369 | 0.091 |
| R-HSA-2187338 | Visual phototransduction | 0.813145 | 0.090 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.813888 | 0.089 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.817343 | 0.088 |
| R-HSA-9758941 | Gastrulation | 0.818382 | 0.087 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.820733 | 0.086 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.820950 | 0.086 |
| R-HSA-418990 | Adherens junctions interactions | 0.820965 | 0.086 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.824061 | 0.084 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.824061 | 0.084 |
| R-HSA-1500620 | Meiosis | 0.824061 | 0.084 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.825991 | 0.083 |
| R-HSA-8951664 | Neddylation | 0.827395 | 0.082 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.828463 | 0.082 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.830533 | 0.081 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.830904 | 0.080 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.836768 | 0.077 |
| R-HSA-162906 | HIV Infection | 0.839664 | 0.076 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.840357 | 0.076 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.851372 | 0.070 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.851372 | 0.070 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.856843 | 0.067 |
| R-HSA-1474290 | Collagen formation | 0.856843 | 0.067 |
| R-HSA-8939211 | ESR-mediated signaling | 0.858446 | 0.066 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.859502 | 0.066 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.864674 | 0.063 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.864674 | 0.063 |
| R-HSA-190236 | Signaling by FGFR | 0.869656 | 0.061 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.869656 | 0.061 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.869656 | 0.061 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.869656 | 0.061 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.869656 | 0.061 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.871693 | 0.060 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.874456 | 0.058 |
| R-HSA-70171 | Glycolysis | 0.874456 | 0.058 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.879079 | 0.056 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.881327 | 0.055 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.883010 | 0.054 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.885698 | 0.053 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.887823 | 0.052 |
| R-HSA-418346 | Platelet homeostasis | 0.889908 | 0.051 |
| R-HSA-211000 | Gene Silencing by RNA | 0.891955 | 0.050 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.893964 | 0.049 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.895936 | 0.048 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.898545 | 0.046 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.901635 | 0.045 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.901635 | 0.045 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.901635 | 0.045 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.908752 | 0.042 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.912202 | 0.040 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.913751 | 0.039 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.915556 | 0.038 |
| R-HSA-3371556 | Cellular response to heat stress | 0.919995 | 0.036 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.922945 | 0.035 |
| R-HSA-73894 | DNA Repair | 0.924685 | 0.034 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.928143 | 0.032 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.933702 | 0.030 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.934636 | 0.029 |
| R-HSA-1474165 | Reproduction | 0.934937 | 0.029 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.938505 | 0.028 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.942961 | 0.026 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.942961 | 0.026 |
| R-HSA-5368287 | Mitochondrial translation | 0.945067 | 0.025 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.945067 | 0.025 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.957791 | 0.019 |
| R-HSA-449147 | Signaling by Interleukins | 0.958085 | 0.019 |
| R-HSA-8953854 | Metabolism of RNA | 0.959579 | 0.018 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.960853 | 0.017 |
| R-HSA-1989781 | PPARA activates gene expression | 0.960853 | 0.017 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.962300 | 0.017 |
| R-HSA-9610379 | HCMV Late Events | 0.962300 | 0.017 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.966074 | 0.015 |
| R-HSA-9824446 | Viral Infection Pathways | 0.968205 | 0.014 |
| R-HSA-5619102 | SLC transporter disorders | 0.968774 | 0.014 |
| R-HSA-416476 | G alpha (q) signalling events | 0.969317 | 0.014 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.971042 | 0.013 |
| R-HSA-72306 | tRNA processing | 0.971042 | 0.013 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.971215 | 0.013 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.972634 | 0.012 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.972634 | 0.012 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.974842 | 0.011 |
| R-HSA-168255 | Influenza Infection | 0.975562 | 0.011 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.979379 | 0.009 |
| R-HSA-983712 | Ion channel transport | 0.979764 | 0.009 |
| R-HSA-112316 | Neuronal System | 0.981644 | 0.008 |
| R-HSA-168256 | Immune System | 0.983264 | 0.007 |
| R-HSA-109582 | Hemostasis | 0.984005 | 0.007 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.984465 | 0.007 |
| R-HSA-8957322 | Metabolism of steroids | 0.988401 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 0.989665 | 0.005 |
| R-HSA-72766 | Translation | 0.990527 | 0.004 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.990850 | 0.004 |
| R-HSA-72312 | rRNA processing | 0.991190 | 0.004 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.991986 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.992969 | 0.003 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.993369 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.993624 | 0.003 |
| R-HSA-913531 | Interferon Signaling | 0.995733 | 0.002 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.996896 | 0.001 |
| R-HSA-597592 | Post-translational protein modification | 0.997371 | 0.001 |
| R-HSA-195721 | Signaling by WNT | 0.997480 | 0.001 |
| R-HSA-1643685 | Disease | 0.999129 | 0.000 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.999572 | 0.000 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.999604 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 0.999691 | 0.000 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.999838 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999929 | 0.000 |
| R-HSA-2262752 | Cellular responses to stress | 0.999981 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999991 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999994 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999996 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999999 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK2 |
0.870 | 0.776 | -3 | 0.682 |
PRKD2 |
0.869 | 0.718 | -3 | 0.626 |
P90RSK |
0.868 | 0.806 | -3 | 0.679 |
RSK3 |
0.868 | 0.776 | -3 | 0.678 |
SRPK2 |
0.867 | 0.749 | -3 | 0.791 |
AKT2 |
0.865 | 0.804 | -3 | 0.762 |
RSK4 |
0.864 | 0.742 | -3 | 0.707 |
PRKD3 |
0.863 | 0.777 | -3 | 0.673 |
MAPKAPK2 |
0.863 | 0.721 | -3 | 0.677 |
MSK2 |
0.862 | 0.759 | -3 | 0.694 |
SGK1 |
0.862 | 0.831 | -3 | 0.828 |
SBK |
0.862 | 0.854 | -3 | 0.848 |
PRKX |
0.862 | 0.658 | -3 | 0.702 |
MSK1 |
0.862 | 0.698 | -3 | 0.679 |
AKT3 |
0.861 | 0.784 | -3 | 0.819 |
SRPK1 |
0.859 | 0.694 | -3 | 0.715 |
PKACA |
0.859 | 0.646 | -2 | 0.767 |
PRKD1 |
0.858 | 0.603 | -3 | 0.526 |
PKACB |
0.857 | 0.612 | -2 | 0.803 |
PIM1 |
0.856 | 0.745 | -3 | 0.639 |
MAPKAPK3 |
0.856 | 0.712 | -3 | 0.592 |
CDKL1 |
0.854 | 0.811 | -3 | 0.628 |
AKT1 |
0.853 | 0.727 | -3 | 0.723 |
CDKL5 |
0.853 | 0.692 | -3 | 0.651 |
CAMK1D |
0.853 | 0.785 | -3 | 0.709 |
P70S6KB |
0.852 | 0.705 | -3 | 0.608 |
CHK2 |
0.851 | 0.835 | -3 | 0.783 |
P70S6K |
0.851 | 0.747 | -3 | 0.715 |
NDR2 |
0.851 | 0.494 | -3 | 0.470 |
PIM3 |
0.851 | 0.664 | -3 | 0.545 |
CAMK1A |
0.850 | 0.784 | -3 | 0.751 |
SGK3 |
0.849 | 0.694 | -3 | 0.624 |
PIM2 |
0.849 | 0.744 | -3 | 0.692 |
PKACG |
0.848 | 0.552 | -2 | 0.860 |
SRPK3 |
0.848 | 0.665 | -3 | 0.718 |
NDR1 |
0.848 | 0.570 | -3 | 0.507 |
CLK1 |
0.847 | 0.638 | -3 | 0.674 |
PKN3 |
0.846 | 0.623 | -3 | 0.520 |
CLK4 |
0.846 | 0.643 | -3 | 0.666 |
SIK |
0.844 | 0.628 | -3 | 0.600 |
MYLK4 |
0.843 | 0.604 | -2 | 0.870 |
CAMK1B |
0.843 | 0.724 | -3 | 0.479 |
MAPKAPK5 |
0.843 | 0.736 | -3 | 0.674 |
LATS2 |
0.842 | 0.427 | -5 | 0.803 |
NUAK1 |
0.842 | 0.602 | -3 | 0.583 |
AMPKA2 |
0.842 | 0.590 | -3 | 0.527 |
HIPK4 |
0.841 | 0.501 | 1 | 0.769 |
NUAK2 |
0.840 | 0.599 | -3 | 0.526 |
MELK |
0.840 | 0.628 | -3 | 0.543 |
CLK2 |
0.840 | 0.609 | -3 | 0.699 |
ICK |
0.840 | 0.643 | -3 | 0.561 |
AURC |
0.839 | 0.365 | -2 | 0.793 |
CAMK4 |
0.839 | 0.556 | -3 | 0.486 |
CAMK1G |
0.839 | 0.686 | -3 | 0.649 |
PKG2 |
0.839 | 0.493 | -2 | 0.814 |
CAMK2D |
0.837 | 0.495 | -3 | 0.454 |
BRSK1 |
0.837 | 0.560 | -3 | 0.579 |
CAMK2A |
0.837 | 0.526 | 2 | 0.816 |
AMPKA1 |
0.837 | 0.529 | -3 | 0.463 |
PKN1 |
0.836 | 0.678 | -3 | 0.687 |
DYRK1A |
0.836 | 0.578 | 1 | 0.732 |
CRIK |
0.834 | 0.753 | -3 | 0.743 |
PKN2 |
0.832 | 0.492 | -3 | 0.463 |
AURB |
0.832 | 0.366 | -2 | 0.785 |
SKMLCK |
0.832 | 0.485 | -2 | 0.919 |
CAMLCK |
0.832 | 0.577 | -2 | 0.916 |
QSK |
0.832 | 0.465 | 4 | 0.851 |
TSSK1 |
0.831 | 0.449 | -3 | 0.445 |
CLK3 |
0.830 | 0.356 | 1 | 0.804 |
CAMK2B |
0.830 | 0.447 | 2 | 0.813 |
DAPK2 |
0.829 | 0.645 | -3 | 0.446 |
DYRK3 |
0.829 | 0.552 | 1 | 0.698 |
MRCKB |
0.829 | 0.664 | -3 | 0.657 |
DCAMKL1 |
0.828 | 0.642 | -3 | 0.579 |
PKG1 |
0.828 | 0.565 | -2 | 0.747 |
MRCKA |
0.827 | 0.643 | -3 | 0.626 |
PAK1 |
0.827 | 0.399 | -2 | 0.874 |
BRSK2 |
0.826 | 0.427 | -3 | 0.494 |
PHKG1 |
0.825 | 0.468 | -3 | 0.501 |
PAK3 |
0.825 | 0.379 | -2 | 0.871 |
AURA |
0.824 | 0.340 | -2 | 0.749 |
PAK6 |
0.824 | 0.294 | -2 | 0.809 |
MNK2 |
0.824 | 0.323 | -2 | 0.883 |
CDC7 |
0.823 | 0.137 | 1 | 0.849 |
HIPK1 |
0.823 | 0.465 | 1 | 0.693 |
DYRK2 |
0.823 | 0.364 | 1 | 0.676 |
PKCD |
0.823 | 0.408 | 2 | 0.726 |
SMMLCK |
0.823 | 0.637 | -3 | 0.556 |
WNK1 |
0.822 | 0.307 | -2 | 0.910 |
MARK4 |
0.821 | 0.267 | 4 | 0.870 |
CHK1 |
0.821 | 0.428 | -3 | 0.435 |
LATS1 |
0.821 | 0.440 | -3 | 0.439 |
TSSK2 |
0.821 | 0.361 | -5 | 0.892 |
HIPK2 |
0.821 | 0.388 | 1 | 0.585 |
MAK |
0.820 | 0.547 | -2 | 0.799 |
QIK |
0.820 | 0.404 | -3 | 0.436 |
HIPK3 |
0.820 | 0.462 | 1 | 0.718 |
NIM1 |
0.820 | 0.337 | 3 | 0.846 |
DCAMKL2 |
0.819 | 0.515 | -3 | 0.546 |
DAPK3 |
0.819 | 0.633 | -3 | 0.593 |
MNK1 |
0.819 | 0.336 | -2 | 0.897 |
DMPK1 |
0.818 | 0.654 | -3 | 0.637 |
NIK |
0.818 | 0.506 | -3 | 0.365 |
DAPK1 |
0.817 | 0.628 | -3 | 0.627 |
PAK2 |
0.817 | 0.370 | -2 | 0.859 |
RAF1 |
0.817 | 0.201 | 1 | 0.892 |
COT |
0.816 | 0.022 | 2 | 0.828 |
PHKG2 |
0.815 | 0.451 | -3 | 0.522 |
PAK5 |
0.814 | 0.346 | -2 | 0.751 |
ROCK2 |
0.814 | 0.616 | -3 | 0.581 |
DYRK1B |
0.814 | 0.367 | 1 | 0.622 |
MST4 |
0.813 | 0.189 | 2 | 0.793 |
SNRK |
0.812 | 0.371 | 2 | 0.664 |
MARK3 |
0.812 | 0.293 | 4 | 0.812 |
MARK1 |
0.812 | 0.333 | 4 | 0.830 |
NLK |
0.812 | 0.147 | 1 | 0.835 |
MOK |
0.812 | 0.569 | 1 | 0.696 |
MOS |
0.811 | 0.082 | 1 | 0.866 |
RIPK3 |
0.811 | 0.110 | 3 | 0.824 |
MARK2 |
0.811 | 0.286 | 4 | 0.782 |
RIPK1 |
0.810 | 0.244 | 1 | 0.852 |
TBK1 |
0.810 | 0.014 | 1 | 0.827 |
WNK3 |
0.810 | 0.168 | 1 | 0.860 |
DYRK4 |
0.810 | 0.312 | 1 | 0.600 |
IKKB |
0.810 | 0.062 | -2 | 0.742 |
PRPK |
0.810 | -0.031 | -1 | 0.885 |
PAK4 |
0.810 | 0.326 | -2 | 0.759 |
ATR |
0.810 | 0.109 | 1 | 0.857 |
PDHK4 |
0.809 | -0.063 | 1 | 0.892 |
PKCB |
0.809 | 0.339 | 2 | 0.661 |
MTOR |
0.809 | -0.002 | 1 | 0.837 |
PKCA |
0.809 | 0.287 | 2 | 0.656 |
PKCT |
0.809 | 0.428 | 2 | 0.665 |
ROCK1 |
0.809 | 0.621 | -3 | 0.628 |
PKCG |
0.808 | 0.309 | 2 | 0.657 |
CAMK2G |
0.808 | 0.044 | 2 | 0.820 |
PKCH |
0.808 | 0.357 | 2 | 0.655 |
IKKE |
0.805 | -0.011 | 1 | 0.817 |
PDHK1 |
0.805 | -0.051 | 1 | 0.890 |
TGFBR2 |
0.804 | 0.076 | -2 | 0.770 |
PKCE |
0.804 | 0.445 | 2 | 0.643 |
GCN2 |
0.804 | -0.091 | 2 | 0.785 |
HUNK |
0.803 | 0.048 | 2 | 0.778 |
BCKDK |
0.803 | -0.003 | -1 | 0.843 |
SSTK |
0.802 | 0.281 | 4 | 0.846 |
MASTL |
0.801 | 0.065 | -2 | 0.823 |
ERK5 |
0.800 | 0.010 | 1 | 0.792 |
BMPR2 |
0.800 | -0.133 | -2 | 0.873 |
PASK |
0.799 | 0.471 | -3 | 0.481 |
ATM |
0.799 | 0.080 | 1 | 0.812 |
ULK2 |
0.799 | -0.115 | 2 | 0.757 |
PKCZ |
0.798 | 0.253 | 2 | 0.717 |
PKCI |
0.797 | 0.331 | 2 | 0.678 |
CDK7 |
0.797 | 0.074 | 1 | 0.658 |
DNAPK |
0.796 | 0.088 | 1 | 0.794 |
DSTYK |
0.796 | -0.129 | 2 | 0.842 |
GRK6 |
0.794 | 0.023 | 1 | 0.849 |
WNK4 |
0.792 | 0.253 | -2 | 0.890 |
DLK |
0.792 | 0.118 | 1 | 0.863 |
GRK5 |
0.791 | -0.101 | -3 | 0.198 |
ULK1 |
0.791 | -0.147 | -3 | 0.153 |
NEK7 |
0.791 | -0.146 | -3 | 0.178 |
GRK1 |
0.791 | -0.001 | -2 | 0.805 |
ANKRD3 |
0.790 | 0.045 | 1 | 0.899 |
CDK10 |
0.790 | 0.198 | 1 | 0.612 |
DRAK1 |
0.789 | 0.181 | 1 | 0.803 |
KIS |
0.789 | -0.012 | 1 | 0.684 |
CHAK2 |
0.789 | -0.036 | -1 | 0.880 |
IKKA |
0.789 | -0.072 | -2 | 0.717 |
FAM20C |
0.789 | 0.062 | 2 | 0.687 |
NEK6 |
0.788 | -0.129 | -2 | 0.828 |
CDK14 |
0.788 | 0.156 | 1 | 0.629 |
NEK9 |
0.788 | -0.109 | 2 | 0.785 |
IRE1 |
0.787 | 0.042 | 1 | 0.791 |
NEK2 |
0.787 | -0.035 | 2 | 0.759 |
MLK1 |
0.787 | -0.109 | 2 | 0.752 |
PDK1 |
0.786 | 0.416 | 1 | 0.881 |
MLK2 |
0.785 | -0.087 | 2 | 0.775 |
SMG1 |
0.784 | -0.019 | 1 | 0.812 |
IRE2 |
0.783 | 0.024 | 2 | 0.702 |
CK1E |
0.783 | -0.076 | -3 | 0.100 |
PKR |
0.783 | 0.070 | 1 | 0.844 |
GRK4 |
0.783 | -0.120 | -2 | 0.815 |
MEK1 |
0.783 | -0.000 | 2 | 0.827 |
TTBK2 |
0.782 | -0.085 | 2 | 0.652 |
CDK8 |
0.782 | -0.030 | 1 | 0.652 |
ALK4 |
0.781 | -0.042 | -2 | 0.801 |
JNK2 |
0.780 | 0.032 | 1 | 0.614 |
PLK1 |
0.780 | -0.034 | -2 | 0.780 |
VRK2 |
0.779 | -0.063 | 1 | 0.884 |
TGFBR1 |
0.779 | -0.047 | -2 | 0.766 |
CDK18 |
0.779 | 0.031 | 1 | 0.578 |
CDK19 |
0.779 | -0.020 | 1 | 0.612 |
BRAF |
0.778 | 0.070 | -4 | 0.822 |
BUB1 |
0.778 | 0.210 | -5 | 0.845 |
BMPR1B |
0.778 | -0.017 | 1 | 0.781 |
CK1A2 |
0.778 | -0.068 | -3 | 0.100 |
P38A |
0.777 | 0.019 | 1 | 0.690 |
CDK9 |
0.777 | 0.033 | 1 | 0.646 |
CK1D |
0.777 | -0.080 | -3 | 0.076 |
IRAK4 |
0.776 | 0.071 | 1 | 0.824 |
YSK4 |
0.776 | -0.071 | 1 | 0.833 |
PLK4 |
0.776 | -0.009 | 2 | 0.618 |
CHAK1 |
0.776 | -0.020 | 2 | 0.736 |
PLK3 |
0.776 | -0.064 | 2 | 0.775 |
ALK2 |
0.776 | -0.028 | -2 | 0.780 |
IRAK1 |
0.774 | 0.012 | -1 | 0.807 |
PRP4 |
0.774 | -0.055 | -3 | 0.158 |
GRK7 |
0.773 | 0.017 | 1 | 0.784 |
MST3 |
0.773 | 0.078 | 2 | 0.766 |
CDK13 |
0.773 | -0.009 | 1 | 0.633 |
MEK5 |
0.773 | 0.019 | 2 | 0.796 |
CDK12 |
0.773 | 0.031 | 1 | 0.610 |
MLK3 |
0.772 | -0.084 | 2 | 0.670 |
JNK3 |
0.772 | -0.005 | 1 | 0.645 |
HRI |
0.771 | -0.081 | -2 | 0.829 |
CK1G1 |
0.771 | -0.100 | -3 | 0.088 |
ACVR2A |
0.770 | -0.070 | -2 | 0.751 |
MPSK1 |
0.770 | 0.015 | 1 | 0.772 |
ACVR2B |
0.770 | -0.079 | -2 | 0.762 |
CDK17 |
0.769 | 0.007 | 1 | 0.523 |
PERK |
0.769 | -0.087 | -2 | 0.814 |
P38B |
0.769 | -0.000 | 1 | 0.616 |
PBK |
0.768 | 0.135 | 1 | 0.756 |
LOK |
0.768 | 0.150 | -2 | 0.827 |
MEKK1 |
0.767 | -0.099 | 1 | 0.856 |
LKB1 |
0.767 | -0.027 | -3 | 0.196 |
NEK5 |
0.767 | -0.084 | 1 | 0.863 |
ERK2 |
0.767 | -0.014 | 1 | 0.658 |
GRK2 |
0.767 | -0.055 | -2 | 0.701 |
MEKK3 |
0.766 | -0.069 | 1 | 0.848 |
TAO3 |
0.766 | 0.056 | 1 | 0.841 |
RIPK2 |
0.766 | 0.071 | 1 | 0.823 |
HPK1 |
0.766 | 0.150 | 1 | 0.840 |
NEK11 |
0.766 | -0.013 | 1 | 0.857 |
CDK5 |
0.766 | -0.012 | 1 | 0.668 |
ZAK |
0.766 | -0.071 | 1 | 0.834 |
TLK2 |
0.765 | -0.116 | 1 | 0.820 |
ERK1 |
0.765 | -0.014 | 1 | 0.615 |
MLK4 |
0.765 | -0.117 | 2 | 0.665 |
TLK1 |
0.765 | -0.074 | -2 | 0.790 |
CAMKK2 |
0.764 | -0.044 | -2 | 0.778 |
PINK1 |
0.764 | -0.127 | 1 | 0.798 |
TAO2 |
0.764 | 0.050 | 2 | 0.790 |
GAK |
0.763 | 0.049 | 1 | 0.832 |
NEK8 |
0.763 | 0.056 | 2 | 0.762 |
TTBK1 |
0.763 | -0.085 | 2 | 0.574 |
MEKK2 |
0.763 | -0.070 | 2 | 0.766 |
P38G |
0.762 | -0.004 | 1 | 0.520 |
MEKK6 |
0.762 | 0.068 | 1 | 0.826 |
GCK |
0.762 | 0.078 | 1 | 0.845 |
BMPR1A |
0.762 | -0.038 | 1 | 0.767 |
NEK4 |
0.761 | -0.029 | 1 | 0.844 |
CDK1 |
0.761 | -0.024 | 1 | 0.601 |
CDK16 |
0.760 | 0.008 | 1 | 0.542 |
CDK4 |
0.759 | 0.083 | 1 | 0.592 |
LRRK2 |
0.759 | 0.139 | 2 | 0.800 |
KHS1 |
0.759 | 0.123 | 1 | 0.843 |
GSK3B |
0.759 | 0.000 | 4 | 0.412 |
CDK2 |
0.759 | -0.050 | 1 | 0.685 |
TAK1 |
0.759 | 0.060 | 1 | 0.878 |
CAMKK1 |
0.759 | -0.134 | -2 | 0.770 |
MAP3K15 |
0.758 | 0.014 | 1 | 0.831 |
KHS2 |
0.758 | 0.143 | 1 | 0.848 |
NEK1 |
0.758 | -0.019 | 1 | 0.845 |
SLK |
0.758 | 0.059 | -2 | 0.754 |
HGK |
0.756 | 0.003 | 3 | 0.853 |
TNIK |
0.756 | 0.038 | 3 | 0.848 |
MINK |
0.755 | 0.004 | 1 | 0.851 |
GRK3 |
0.754 | -0.064 | -2 | 0.653 |
NEK3 |
0.752 | -0.013 | 1 | 0.825 |
P38D |
0.751 | -0.021 | 1 | 0.550 |
GSK3A |
0.751 | -0.011 | 4 | 0.420 |
YSK1 |
0.750 | 0.025 | 2 | 0.748 |
CDK3 |
0.750 | -0.010 | 1 | 0.540 |
ERK7 |
0.749 | -0.024 | 2 | 0.474 |
MST2 |
0.749 | -0.120 | 1 | 0.856 |
PLK2 |
0.749 | -0.081 | -3 | 0.126 |
HASPIN |
0.749 | 0.116 | -1 | 0.742 |
STK33 |
0.748 | -0.024 | 2 | 0.585 |
MEK2 |
0.748 | -0.108 | 2 | 0.792 |
PDHK3_TYR |
0.747 | 0.075 | 4 | 0.905 |
VRK1 |
0.747 | -0.039 | 2 | 0.784 |
CDK6 |
0.746 | 0.001 | 1 | 0.614 |
MST1 |
0.745 | -0.081 | 1 | 0.841 |
CK2A2 |
0.745 | -0.027 | 1 | 0.675 |
LIMK2_TYR |
0.745 | 0.188 | -3 | 0.280 |
TESK1_TYR |
0.744 | 0.118 | 3 | 0.913 |
EEF2K |
0.744 | -0.070 | 3 | 0.808 |
YANK3 |
0.743 | 0.020 | 2 | 0.381 |
JNK1 |
0.743 | -0.028 | 1 | 0.587 |
PKMYT1_TYR |
0.740 | 0.059 | 3 | 0.901 |
MAP2K4_TYR |
0.740 | 0.099 | -1 | 0.902 |
RET |
0.739 | 0.089 | 1 | 0.851 |
BIKE |
0.738 | 0.017 | 1 | 0.705 |
MAP2K7_TYR |
0.738 | 0.028 | 2 | 0.841 |
TAO1 |
0.738 | 0.050 | 1 | 0.796 |
PINK1_TYR |
0.737 | 0.178 | 1 | 0.859 |
DDR1 |
0.737 | 0.119 | 4 | 0.836 |
ASK1 |
0.736 | -0.030 | 1 | 0.820 |
PDHK4_TYR |
0.735 | -0.045 | 2 | 0.875 |
CK1A |
0.735 | -0.112 | -3 | 0.046 |
EPHA6 |
0.735 | 0.043 | -1 | 0.884 |
MAP2K6_TYR |
0.734 | -0.010 | -1 | 0.906 |
TTK |
0.733 | -0.024 | -2 | 0.793 |
MST1R |
0.733 | 0.038 | 3 | 0.867 |
CK2A1 |
0.733 | -0.041 | 1 | 0.651 |
MYO3B |
0.732 | -0.015 | 2 | 0.766 |
LIMK1_TYR |
0.732 | 0.046 | 2 | 0.819 |
BMPR2_TYR |
0.731 | -0.028 | -1 | 0.890 |
TNK2 |
0.731 | 0.080 | 3 | 0.828 |
PDHK1_TYR |
0.730 | -0.067 | -1 | 0.912 |
EPHB4 |
0.730 | -0.006 | -1 | 0.878 |
TNK1 |
0.730 | 0.120 | 3 | 0.836 |
ROS1 |
0.729 | 0.003 | 3 | 0.823 |
DDR2 |
0.728 | 0.171 | 3 | 0.813 |
NEK10_TYR |
0.728 | 0.097 | 1 | 0.756 |
ALPHAK3 |
0.728 | -0.048 | -1 | 0.794 |
TYRO3 |
0.727 | -0.037 | 3 | 0.847 |
OSR1 |
0.727 | -0.102 | 2 | 0.766 |
TYK2 |
0.726 | -0.061 | 1 | 0.855 |
JAK3 |
0.725 | -0.013 | 1 | 0.840 |
JAK2 |
0.725 | -0.079 | 1 | 0.858 |
MYO3A |
0.725 | -0.045 | 1 | 0.814 |
AXL |
0.723 | 0.022 | 3 | 0.856 |
AAK1 |
0.723 | 0.030 | 1 | 0.595 |
FGFR2 |
0.723 | -0.006 | 3 | 0.871 |
CSF1R |
0.722 | -0.067 | 3 | 0.855 |
INSRR |
0.722 | -0.001 | 3 | 0.818 |
ABL2 |
0.721 | -0.030 | -1 | 0.840 |
EPHA4 |
0.721 | -0.047 | 2 | 0.771 |
EPHB3 |
0.720 | -0.042 | -1 | 0.866 |
TNNI3K_TYR |
0.720 | 0.008 | 1 | 0.842 |
TEK |
0.720 | -0.034 | 3 | 0.802 |
EPHB1 |
0.720 | -0.060 | 1 | 0.865 |
PDGFRB |
0.720 | -0.009 | 3 | 0.862 |
KDR |
0.720 | 0.011 | 3 | 0.835 |
CK1G3 |
0.719 | -0.108 | -3 | 0.035 |
FGR |
0.719 | -0.081 | 1 | 0.852 |
YES1 |
0.719 | -0.065 | -1 | 0.869 |
JAK1 |
0.719 | -0.010 | 1 | 0.826 |
SRMS |
0.718 | -0.072 | 1 | 0.860 |
FGFR1 |
0.718 | -0.038 | 3 | 0.844 |
STLK3 |
0.718 | -0.124 | 1 | 0.807 |
FER |
0.718 | -0.107 | 1 | 0.874 |
TXK |
0.717 | -0.045 | 1 | 0.828 |
ABL1 |
0.717 | -0.055 | -1 | 0.832 |
EPHA1 |
0.717 | 0.016 | 3 | 0.831 |
EPHB2 |
0.717 | -0.061 | -1 | 0.856 |
FLT3 |
0.716 | -0.020 | 3 | 0.842 |
MERTK |
0.715 | -0.050 | 3 | 0.853 |
ITK |
0.715 | -0.062 | -1 | 0.839 |
EPHA7 |
0.715 | -0.029 | 2 | 0.767 |
PDGFRA |
0.715 | -0.038 | 3 | 0.855 |
HCK |
0.714 | -0.105 | -1 | 0.851 |
LCK |
0.714 | -0.063 | -1 | 0.849 |
LTK |
0.713 | 0.004 | 3 | 0.817 |
KIT |
0.713 | -0.094 | 3 | 0.861 |
ALK |
0.712 | -0.016 | 3 | 0.788 |
EPHA3 |
0.711 | -0.060 | 2 | 0.742 |
BLK |
0.711 | -0.049 | -1 | 0.853 |
TEC |
0.710 | -0.058 | -1 | 0.777 |
BMX |
0.709 | -0.049 | -1 | 0.754 |
MET |
0.709 | -0.072 | 3 | 0.852 |
BTK |
0.709 | -0.116 | -1 | 0.812 |
FGFR3 |
0.708 | -0.052 | 3 | 0.848 |
NTRK1 |
0.707 | -0.099 | -1 | 0.850 |
FLT4 |
0.707 | -0.049 | 3 | 0.832 |
FLT1 |
0.706 | -0.069 | -1 | 0.857 |
EPHA5 |
0.705 | -0.043 | 2 | 0.765 |
NTRK2 |
0.705 | -0.101 | 3 | 0.832 |
PTK2B |
0.705 | -0.033 | -1 | 0.809 |
ERBB2 |
0.704 | -0.107 | 1 | 0.797 |
WEE1_TYR |
0.704 | -0.057 | -1 | 0.790 |
INSR |
0.703 | -0.082 | 3 | 0.791 |
PTK6 |
0.703 | -0.123 | -1 | 0.778 |
FYN |
0.702 | -0.076 | -1 | 0.819 |
FRK |
0.700 | -0.101 | -1 | 0.866 |
LYN |
0.700 | -0.115 | 3 | 0.792 |
EPHA8 |
0.699 | -0.075 | -1 | 0.842 |
NTRK3 |
0.698 | -0.107 | -1 | 0.804 |
YANK2 |
0.696 | -0.063 | 2 | 0.401 |
CSK |
0.696 | -0.088 | 2 | 0.765 |
MATK |
0.694 | -0.100 | -1 | 0.765 |
SRC |
0.692 | -0.110 | -1 | 0.821 |
EGFR |
0.691 | -0.101 | 1 | 0.709 |
FGFR4 |
0.690 | -0.099 | -1 | 0.797 |
EPHA2 |
0.690 | -0.075 | -1 | 0.804 |
PTK2 |
0.688 | -0.052 | -1 | 0.795 |
IGF1R |
0.686 | -0.091 | 3 | 0.743 |
CK1G2 |
0.685 | -0.113 | -3 | 0.059 |
SYK |
0.683 | -0.092 | -1 | 0.786 |
MUSK |
0.682 | -0.104 | 1 | 0.688 |
ERBB4 |
0.680 | -0.087 | 1 | 0.704 |
FES |
0.673 | -0.124 | -1 | 0.731 |
ZAP70 |
0.660 | -0.089 | -1 | 0.708 |