Motif 340 (n=271)

Position-wise Probabilities

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uniprot genes site source protein function
A1L390 PLEKHG3 S759 ochoa Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.
A1L390 PLEKHG3 S1081 ochoa Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.
A6ND36 FAM83G S650 ochoa Protein FAM83G (Protein associated with SMAD1) Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}.
A7KAX9 ARHGAP32 S1585 ochoa Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.
A7KAX9 ARHGAP32 S1796 ochoa Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.
E7EW31 PROB1 S306 ochoa Proline-rich basic protein 1 None
O00116 AGPS S589 ochoa Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}.
O14497 ARID1A S638 ochoa|psp AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
O14545 TRAFD1 S409 ochoa TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}.
O14639 ABLIM1 S706 ochoa Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}.
O14908 GIPC1 S232 ochoa PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) May be involved in G protein-linked signaling.
O15018 PDZD2 S543 ochoa PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] None
O15018 PDZD2 S944 ochoa PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] None
O15151 MDM4 S367 ochoa|psp Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}.
O43182 ARHGAP6 S213 ochoa Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.
O43255 SIAH2 S167 psp E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11483518, PubMed:19224863, PubMed:9334332). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11483518, PubMed:19224863, PubMed:22878263, PubMed:9334332). Has some overlapping function with SIAH1 (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1. {ECO:0000250|UniProtKB:Q06986, ECO:0000269|PubMed:11483518, ECO:0000269|PubMed:12411493, ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:28546513, ECO:0000269|PubMed:9334332}.
O43815 STRN S672 ochoa Striatin Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}.
O60292 SIPA1L3 S97 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O60296 TRAK2 S420 ochoa Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}.
O60296 TRAK2 S889 ochoa Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}.
O60664 PLIN3 S31 ochoa Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.
O75140 DEPDC5 S570 ochoa GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}.
O75157 TSC22D2 S598 ochoa TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4) Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth. {ECO:0000269|PubMed:27573352}.
O75179 ANKRD17 S2489 ochoa Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.
O75376 NCOR1 Y89 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75791 GRAP2 T262 ochoa|psp GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
O75925 PIAS1 S510 ochoa|psp E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}.
O94761 RECQL4 S101 ochoa ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4) An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction (PubMed:28653661). Does not unwind more than 18 bp of dsDNA (PubMed:28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed:22730300). The core helicase domain binds ssDNA (PubMed:22730300, PubMed:28653661). {ECO:0000269|PubMed:15317757, ECO:0000269|PubMed:22730300, ECO:0000269|PubMed:28653661}.
O94885 SASH1 S923 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O94972 TRIM37 S454 ochoa E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}.
O95049 TJP3 S346 ochoa Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}.
O95208 EPN2 S173 ochoa Epsin-2 (EPS-15-interacting protein 2) Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}.
P00973 OAS1 S50 ochoa 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34145065, PubMed:34581622). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:12799444, ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:23319625, ECO:0000269|PubMed:34145065, ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p46]: When prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target (PubMed:34581622). The same mechanism is necessary to initiate a block to cardiovirus EMCV (PubMed:34581622). {ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p42]: Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}.
P04049 RAF1 S259 ochoa|psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P04049 RAF1 S621 ochoa|psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P05177 CYP1A2 S82 ochoa Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14725854, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21068195, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:9435160, ECO:0000305|PubMed:16522833}.
P05549 TFAP2A S239 ochoa|psp Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}.
P06576 ATP5F1B S465 ochoa ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}.
P08559 PDHA1 S314 psp Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}.
P10276 RARA S369 psp Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:21152046, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}.
P10398 ARAF S582 ochoa|psp Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}.
P11836 MS4A1 S36 ochoa B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739). {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:18474602, ECO:0000269|PubMed:3925015, ECO:0000269|PubMed:7684739}.
P13631 RARG S371 psp Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}.
P15056 BRAF S729 ochoa|psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P16144 ITGB4 S1325 psp Integrin beta-4 (GP150) (CD antigen CD104) Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P17752 TPH1 S260 psp Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. {ECO:0000250|UniProtKB:P17532}.
P18887 XRCC1 S151 ochoa DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}.
P21730 C5AR1 S314 psp C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.
P23229 ITGA6 S638 ochoa Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000250|UniProtKB:Q61739, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P26045 PTPN3 S835 psp Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
P26358 DNMT1 S878 ochoa|psp DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}.
P26373 RPL13 S52 ochoa Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}.
P26641 EEF1G S33 ochoa Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) Probably plays a role in anchoring the complex to other cellular components.
P28290 ITPRID2 S739 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P30304 CDC25A S107 psp M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P30304 CDC25A S178 ochoa|psp M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P30305 CDC25B S151 ochoa|psp M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P30305 CDC25B S230 ochoa|psp M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P32927 CSF2RB S601 ochoa|psp Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}.
P35670 ATP7B S1121 psp Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}.
P39880 CUX1 S425 ochoa Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
P41252 IARS1 S346 ochoa Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}.
P47736 RAP1GAP S490 psp Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}.
P48147 PREP S667 ochoa Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
P49792 RANBP2 S1509 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50549 ETV1 S191 ochoa|psp ETS translocation variant 1 (Ets-related protein 81) Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}.
P50549 ETV1 S216 ochoa|psp ETS translocation variant 1 (Ets-related protein 81) Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}.
P52597 HNRNPF S195 ochoa Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
P52943 CRIP2 S104 ochoa Cysteine-rich protein 2 (CRP-2) (Protein ESP1) None
P53804 TTC3 S378 ochoa|psp E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). {ECO:0000269|PubMed:17488780, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:24695496, ECO:0000269|PubMed:30203323, ECO:0000269|PubMed:30696809}.
P58340 MLF1 S34 ochoa Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}.
P83369 LSM11 S280 ochoa U7 snRNA-associated Sm-like protein LSm11 Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750). {ECO:0000250|UniProtKB:Q8BUV6, ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:16914750, ECO:0000269|PubMed:33230297}.
Q00610 CLTC S403 ochoa Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q03164 KMT2A S3027 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q04206 RELA S281 psp Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}.
Q08495 DMTN S269 ochoa Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.
Q08495 DMTN S333 ochoa Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.
Q09019 DMWD S495 ochoa Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}.
Q12774 ARHGEF5 S606 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12802 AKAP13 S1226 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q12968 NFATC3 S416 ochoa Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}.
Q13009 TIAM1 S60 ochoa|psp Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}.
Q13418 ILK S246 psp Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447). {ECO:0000250|UniProtKB:O55222, ECO:0000250|UniProtKB:Q99J82, ECO:0000269|PubMed:16517730, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:18283114, ECO:0000269|PubMed:20005845, ECO:0000269|PubMed:30367047, ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:9736715}.
Q13425 SNTB2 S258 ochoa Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Q13625 TP53BP2 S361 ochoa|psp Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q13698 CACNA1S S1617 ochoa Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1) Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. {ECO:0000269|PubMed:28012042}.
Q13873 BMPR2 S757 ochoa|psp Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}.
Q14005 IL16 S966 ochoa Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Q14151 SAFB2 S787 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14432 PDE3A S312 ochoa|psp cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}.
Q14451 GRB7 S63 ochoa Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}.
Q14678 KANK1 S70 ochoa KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}.
Q15390 MTFR1 S119 ochoa Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}.
Q15418 RPS6KA1 S307 ochoa Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}.
Q15697 ZNF174 S265 ochoa Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) Transcriptional repressor. {ECO:0000269|PubMed:7673192}.
Q15785 TOMM34 S160 ochoa Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}.
Q15884 ENTREP1 S275 ochoa Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin) Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway. {ECO:0000269|PubMed:34927784}.
Q2KHR2 RFX7 S1225 ochoa DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250|UniProtKB:A0A1L8H0H2, ECO:0000269|PubMed:29967452, ECO:0000269|PubMed:34197623}.
Q2LD37 BLTP1 S703 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q2M1Z3 ARHGAP31 S272 ochoa Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}.
Q3KP66 INAVA S616 ochoa Innate immunity activator protein Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}.
Q4AC94 C2CD3 S2328 ochoa C2 domain-containing protein 3 Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}.
Q4G0A6 MINDY4 S352 ochoa Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4) Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000250|UniProtKB:Q8NBR6}.
Q4VX76 SYTL3 S243 ochoa Synaptotagmin-like protein 3 (Exophilin-6) May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). {ECO:0000250}.
Q52LW3 ARHGAP29 S1019 ochoa Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
Q5JXC2 MIIP S113 ochoa Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45) Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269|PubMed:14617774}.
Q5PRF9 SAMD4B S642 psp Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}.
Q5T0W9 FAM83B S914 ochoa Protein FAM83B Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.
Q5T0Z8 C6orf132 S314 ochoa Uncharacterized protein C6orf132 None
Q5T0Z8 C6orf132 S1087 ochoa Uncharacterized protein C6orf132 None
Q5T447 HECTD3 S192 psp E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}.
Q5T5C0 STXBP5 S759 ochoa Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.
Q5TC79 ZBTB37 S188 ochoa Zinc finger and BTB domain-containing protein 37 May be involved in transcriptional regulation.
Q5VSL9 STRIP1 S788 ochoa Striatin-interacting protein 1 (Protein FAM40A) Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}.
Q5VUJ6 LRCH2 S327 ochoa Leucine-rich repeat and calponin homology domain-containing protein 2 May play a role in the organization of the cytoskeleton. {ECO:0000250|UniProtKB:Q960C5, ECO:0000250|UniProtKB:Q96II8}.
Q5VV41 ARHGEF16 S578 ochoa Rho guanine nucleotide exchange factor 16 (Ephexin-4) Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}.
Q5VZL5 ZMYM4 S882 ochoa Zinc finger MYM-type protein 4 (Zinc finger protein 262) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
Q6AI14 SLC9A4 S660 ochoa Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity). {ECO:0000250|UniProtKB:P26434, ECO:0000250|UniProtKB:Q8BUE1}.
Q6FI81 CIAPIN1 S287 ochoa Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}.
Q6N021 TET2 S99 ochoa|psp Methylcytosine dioxygenase TET2 (EC 1.14.11.80) Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}.
Q6NSI3 FAM53A S125 ochoa Protein FAM53A (Dorsal neural-tube nuclear protein) May play an important role in neural development; the dorsomedial roof of the third ventricle. {ECO:0000250|UniProtKB:Q5ZKN5}.
Q6P2E9 EDC4 S405 psp Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6P3S6 FBXO42 S488 ochoa F-box only protein 42 (Just one F-box and Kelch domain-containing protein) Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}.
Q6P5Z2 PKN3 S488 ochoa Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}.
Q6PIJ6 FBXO38 S850 ochoa F-box only protein 38 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}.
Q6UB99 ANKRD11 S1814 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6VUC0 TFAP2E S246 ochoa Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}.
Q6VY07 PACS1 S519 ochoa Phosphofurin acidic cluster sorting protein 1 (PACS-1) Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}.
Q6Y7W6 GIGYF2 S684 ochoa GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}.
Q6ZV29 PNPLA7 S355 ochoa Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5) Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). {ECO:0000250|UniProtKB:A2AJ88}.
Q711Q0 CEFIP S160 ochoa Cardiac-enriched FHL2-interacting protein Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}.
Q7Z309 PABIR2 S25 ochoa PABIR family member 2 None
Q7Z333 SETX T2474 ochoa Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}.
Q7Z3C6 ATG9A S761 ochoa|psp Autophagy-related protein 9A (APG9-like 1) (mATG9) Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}.
Q7Z401 DENND4A S755 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q7Z5H3 ARHGAP22 S395 ochoa|psp Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}.
Q7Z698 SPRED2 S206 ochoa Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}.
Q86TB3 ALPK2 S1078 ochoa Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000269|PubMed:29888752, ECO:0000303|PubMed:10021370}.
Q86UR1 NOXA1 S172 psp NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox) Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:14978110, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17602954, ECO:0000269|PubMed:19755710}.
Q86V87 FHIP2B S325 psp FHF complex subunit HOOK-interacting protein 2B (FHIP2B) (Retinoic acid-induced protein 16) Able to activate MAPK/ERK and TGFB signaling pathways (PubMed:22971576). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (By similarity). May play a role in cell proliferation (PubMed:22971576). {ECO:0000250|UniProtKB:Q80YR2, ECO:0000269|PubMed:22971576}.
Q86VQ1 GLCCI1 S172 ochoa Glucocorticoid-induced transcript 1 protein None
Q86W92 PPFIBP1 S540 ochoa Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.
Q86WR7 PROSER2 S400 ochoa Proline and serine-rich protein 2 None
Q86X10 RALGAPB S359 ochoa Ral GTPase-activating protein subunit beta (p170) Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q86YV0 RASAL3 S72 ochoa RAS protein activator like-3 Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.
Q86YV0 RASAL3 S819 ochoa RAS protein activator like-3 Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.
Q8IUW3 SPATA2L S317 ochoa Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) None
Q8IVE3 PLEKHH2 S459 ochoa Pleckstrin homology domain-containing family H member 2 In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.
Q8IY18 SMC5 S35 ochoa Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}.
Q8IYK8 REM2 S68 ochoa GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}.
Q8IYT8 ULK2 S528 ochoa Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}.
Q8IZU2 WDR17 S1198 ochoa WD repeat-containing protein 17 None
Q8N103 TAGAP S377 ochoa T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) May function as a GTPase-activating protein and may play important roles during T-cell activation. {ECO:0000269|PubMed:15177553}.
Q8N1W1 ARHGEF28 S535 ochoa Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.
Q8N1W1 ARHGEF28 S1538 ochoa Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.
Q8N4X5 AFAP1L2 S484 ochoa Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}.
Q8N5H7 SH2D3C S447 ochoa SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}.
Q8N5S9 CAMKK1 S475 ochoa|psp Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}.
Q8N8S7 ENAH S537 ochoa Protein enabled homolog Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}.
Q8NCE2 MTMR14 S415 ochoa Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}.
Q8NFD5 ARID1B S747 psp AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q8TBA6 GOLGA5 S116 ochoa Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}.
Q8TBC3 SHKBP1 T163 ochoa SH3KBP1-binding protein 1 (SETA-binding protein 1) Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}.
Q8TBZ3 WDR20 S434 ochoa WD repeat-containing protein 20 (Protein DMR) Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}.
Q8TDM6 DLG5 S1115 ochoa|psp Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TEW0 PARD3 S144 ochoa|psp Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.
Q8TEW8 PARD3B S141 ochoa Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8TF42 UBASH3B S377 ochoa Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}.
Q8TF72 SHROOM3 S1242 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8WUA7 TBC1D22A S167 ochoa TBC1 domain family member 22A May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}.
Q8WXD9 CASKIN1 S1067 ochoa Caskin-1 (CASK-interacting protein 1) May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WYL5 SSH1 S515 ochoa Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}.
Q8WZ82 OVCA2 S168 ochoa Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase domain-containing protein) (Ovarian cancer-associated gene 2 protein) Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons. {ECO:0000269|PubMed:32182256}.
Q92481 TFAP2B S258 ochoa Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}.
Q92622 RUBCN S248 ochoa Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}.
Q92754 TFAP2C S252 ochoa Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}.
Q92794 KAT6A S1861 ochoa Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.
Q92932 PTPRN2 S375 ochoa Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}.
Q92974 ARHGEF2 S886 ochoa|psp Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}.
Q96A59 MARVELD3 S156 ochoa MARVEL domain-containing protein 3 As a component of tight junctions, plays a role in paracellular ion conductivity. {ECO:0000269|PubMed:20028514}.
Q96A65 EXOC4 S410 ochoa Exocyst complex component 4 (Exocyst complex component Sec8) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}.
Q96AD5 PNPLA2 S404 ochoa Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2) Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). {ECO:0000250|UniProtKB:Q8BJ56, ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:17032652, ECO:0000269|PubMed:17603008, ECO:0000269|PubMed:28578400, ECO:0000269|PubMed:34903883, ECO:0000269|PubMed:35676490}.
Q96B18 DACT3 S188 ochoa Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}.
Q96EP0 RNF31 S466 ochoa E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}.
Q96JQ2 CLMN S419 ochoa Calmin (Calponin-like transmembrane domain protein) None
Q96K78 ADGRG7 S746 ochoa Adhesion G-protein coupled receptor G7 (G-protein coupled receptor 128) Orphan receptor.
Q96MU7 YTHDC1 S515 ochoa YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.
Q96N96 SPATA13 T617 psp Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}.
Q96NW4 ANKRD27 S962 ochoa Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:23104059, ECO:0000269|PubMed:24856514, ECO:0000305|PubMed:16525121, ECO:0000305|PubMed:18477474, ECO:0000305|PubMed:22705394}.
Q96P16 RPRD1A S285 ochoa Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.
Q96PE2 ARHGEF17 S735 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96PY6 NEK1 S1052 ochoa Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}.
Q96Q42 ALS2 S483 ochoa|psp Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}.
Q96S53 TESK2 S346 ochoa Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.
Q96S53 TESK2 S456 ochoa Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.
Q96TC7 RMDN3 S46 ochoa|psp Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}.
Q99570 PIK3R4 S755 ochoa Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}.
Q99698 LYST S2105 ochoa Lysosomal-trafficking regulator (Beige homolog) Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}.
Q99973 TEP1 S2353 ochoa Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). {ECO:0000250|UniProtKB:P97499, ECO:0000269|PubMed:19179534}.
Q99983 OMD S226 ochoa Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. {ECO:0000250|UniProtKB:O77742}.
Q9BQ48 MRPL34 S71 ochoa Large ribosomal subunit protein bL34m (39S ribosomal protein L34, mitochondrial) (L34mt) (MRP-L34) None
Q9BU19 ZNF692 S470 psp Zinc finger protein 692 (AICAR responsive element binding protein) May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}.
Q9BWT7 CARD10 S638 ochoa Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}.
Q9BZF2 OSBPL7 S226 ochoa Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7) None
Q9BZF3 OSBPL6 S290 ochoa Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}.
Q9C073 FAM117A S67 ochoa Protein FAM117A (C/EBP-induced protein) None
Q9C073 FAM117A S91 ochoa Protein FAM117A (C/EBP-induced protein) None
Q9C0I1 MTMR12 S564 ochoa Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:11504939, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:23818870}.
Q9C0K0 BCL11B S110 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9GZY8 MFF S179 ochoa Mitochondrial fission factor Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}.
Q9H019 MTFR1L S103 ochoa Mitochondrial fission regulator 1-like Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}.
Q9H1H9 KIF13A S1384 ochoa Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}.
Q9H1K1 ISCU S29 ochoa Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable) (PubMed:24971490, PubMed:29576242, PubMed:30031876, PubMed:34824239). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}.
Q9H4A3 WNK1 S167 ochoa Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}.
Q9H4A3 WNK1 S2286 ochoa Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}.
Q9H4L5 OSBPL3 S251 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9H6Z4 RANBP3 S333 ochoa Ran-binding protein 3 (RanBP3) Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}.
Q9HA47 UCK1 S253 ochoa Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}.
Q9HB20 PLEKHA3 S211 ochoa Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}.
Q9HC77 CPAP S1109 ochoa|psp Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}.
Q9NP56 PDE7B S45 ochoa 3',5'-cyclic-AMP phosphodiesterase 7B (EC 3.1.4.53) (cAMP-specific phosphodiesterase 7B) Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:10814504, PubMed:10872825). May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (PubMed:10814504). {ECO:0000269|PubMed:10814504, ECO:0000269|PubMed:10872825}.
Q9NQT8 KIF13B S1381 ochoa|psp Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}.
Q9NRA0 SPHK2 Y378 psp Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}.
Q9NRL3 STRN4 S635 ochoa Striatin-4 (Zinedin) Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}.
Q9NVI7 ATAD3A S357 ochoa ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:17210950, PubMed:20154147, PubMed:22453275, PubMed:31522117, PubMed:37832546, PubMed:39116259). May play an important role in mitochondrial protein synthesis (PubMed:22453275). May also participate in mitochondrial DNA replication (PubMed:17210950). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (PubMed:17210950). Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (PubMed:22453275). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress (PubMed:39116259). Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity (PubMed:39116259). Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR) (PubMed:37832546). {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:39116259}.
Q9NYF3 FAM53C S122 ochoa Protein FAM53C None
Q9NYL2 MAP3K20 S593 ochoa Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.
Q9NZQ3 NCKIPSD S147 ochoa NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.
Q9NZV7 ZIM2 S26 ochoa Zinc finger imprinted 2 (Zinc finger protein 656) May be involved in transcriptional regulation.
Q9P203 BTBD7 S794 ochoa BTB/POZ domain-containing protein 7 Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}.
Q9P243 ZFAT S53 ochoa Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}.
Q9P246 STIM2 S719 ochoa Stromal interaction molecule 2 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
Q9P266 JCAD S1044 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9UBD5 ORC3 S23 ochoa Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:31160578}.
Q9UBP0 SPAST S245 ochoa Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}.
Q9UBS0 RPS6KB2 S416 ochoa Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}.
Q9UBY9 HSPB7 S60 ochoa Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) None
Q9UJ83 HACL1 S192 ochoa 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:10468558, PubMed:21708296, PubMed:28289220). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:10468558, PubMed:21708296, PubMed:28289220). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}.
Q9UKE5 TNIK S640 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9UKE5 TNIK S701 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9UKF7 PITPNC1 S299 ochoa|psp Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}.
Q9UKN1 MUC12 S1616 ochoa Mucin-12 (MUC-12) (Mucin-11) (MUC-11) Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}.
Q9UKV8 AGO2 S798 psp Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}.
Q9ULR3 PPM1H S124 ochoa Protein phosphatase 1H (EC 3.1.3.16) Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269|PubMed:22586611}.
Q9ULV3 CIZ1 S868 ochoa Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) May regulate the subcellular localization of CIP/WAF1.
Q9UNH5 CDC14A S429 psp Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}.
Q9UNI6 DUSP12 S241 ochoa Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}.
Q9UPA5 BSN S2851 ochoa Protein bassoon (Zinc finger protein 231) Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}.
Q9UPN9 TRIM33 S622 ochoa E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.
Q9UPQ0 LIMCH1 S493 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UPU9 SAMD4A S665 ochoa Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}.
Q9UPV9 TRAK1 S919 ochoa Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}.
Q9UPY3 DICER1 S643 ochoa Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}.
Q9Y2G4 ANKRD6 S289 ochoa Ankyrin repeat domain-containing protein 6 (Diversin) Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000250}.
Q9Y2I9 TBC1D30 S744 ochoa TBC1 domain family member 30 May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}.
Q9Y2R2 PTPN22 S449 ochoa Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}.
Q9Y2U8 LEMD3 S291 ochoa Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y2U8 LEMD3 S777 ochoa Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y4A5 TRRAP S2077 ochoa Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}.
Q9Y580 RBM7 S136 ochoa|psp RNA-binding protein 7 (RNA-binding motif protein 7) RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104, PubMed:27871484). NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:25189701, PubMed:25852104, PubMed:27871484). Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104). Participates in several biological processes including DNA damage response (DDR) and stress response (PubMed:25525152, PubMed:30824372). During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome (PubMed:25525152). Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability (PubMed:30824372). {ECO:0000269|PubMed:25189701, ECO:0000269|PubMed:25525152, ECO:0000269|PubMed:25578728, ECO:0000269|PubMed:25852104, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:30824372}.
Q9Y678 COPG1 S593 ochoa Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}.
Q9Y6Q9 NCOA3 S967 ochoa Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
P27824 CANX S362 Sugiyama Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Q9UQ80 PA2G4 S335 Sugiyama Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}.
Q12809 KCNH2 S1137 ELM|EPSD Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1) Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Channel properties are modulated by cAMP and subunit assembly (PubMed:10837251). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (PubMed:10219239, PubMed:9230439). {ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:10753933, ECO:0000269|PubMed:10790218, ECO:0000269|PubMed:10837251, ECO:0000269|PubMed:11997281, ECO:0000269|PubMed:12063277, ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:22314138, ECO:0000269|PubMed:22359612, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:9230439, ECO:0000269|PubMed:9351446, ECO:0000269|PubMed:9765245}.; FUNCTION: [Isoform A-USO]: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:9765245}.; FUNCTION: [Isoform B-USO]: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421}.
Q16613 AANAT T31 ELM|iPTMNet|EPSD Serotonin N-acetyltransferase (Serotonin acetylase) (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT) Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. {ECO:0000269|PubMed:11313340, ECO:0000305}.
Q8TD08 MAPK15 S415 Sugiyama Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}.
P52952 NKX2-5 S164 SIGNOR|iPTMNet Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E) Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (PubMed:29899023). {ECO:0000250|UniProtKB:P42582, ECO:0000269|PubMed:22560297, ECO:0000269|PubMed:22849347, ECO:0000269|PubMed:26926761, ECO:0000269|PubMed:29899023}.
P08174 CD55 S138 Sugiyama Complement decay-accelerating factor (CD antigen CD55) This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.
Q9BUP3 HTATIP2 S177 Sugiyama Protein HTATIP2 (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2) Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672). {ECO:0000250|UniProtKB:B0BNF8, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:18519672}.
Q13111 CHAF1A S777 Sugiyama Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150) Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250|UniProtKB:Q5R1T0}.
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reactome_id name p -log10_p
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 0.000002 5.717
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.000013 4.890
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.000070 4.153
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.000320 3.495
R-HSA-9700206 Signaling by ALK in cancer 0.000320 3.495
R-HSA-9827857 Specification of primordial germ cells 0.000691 3.161
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.000802 3.096
R-HSA-9660537 Signaling by MRAS-complex mutants 0.001054 2.977
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.001054 2.977
R-HSA-9834899 Specification of the neural plate border 0.000952 3.021
R-HSA-193648 NRAGE signals death through JNK 0.001085 2.965
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.002519 2.599
R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors 0.003681 2.434
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.003278 2.484
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.003595 2.444
R-HSA-193704 p75 NTR receptor-mediated signalling 0.003779 2.423
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.003481 2.458
R-HSA-416482 G alpha (12/13) signalling events 0.004638 2.334
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 0.005239 2.281
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.005999 2.222
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.006442 2.191
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.009100 2.041
R-HSA-9730414 MITF-M-regulated melanocyte development 0.009362 2.029
R-HSA-426486 Small interfering RNA (siRNA) biogenesis 0.011384 1.944
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.010323 1.986
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.011464 1.941
R-HSA-9856651 MITF-M-dependent gene expression 0.010903 1.962
R-HSA-5675221 Negative regulation of MAPK pathway 0.011753 1.930
R-HSA-73887 Death Receptor Signaling 0.012405 1.906
R-HSA-446107 Type I hemidesmosome assembly 0.016618 1.779
R-HSA-1483255 PI Metabolism 0.016182 1.791
R-HSA-9932451 SWI/SNF chromatin remodelers 0.018225 1.739
R-HSA-9932444 ATP-dependent chromatin remodelers 0.018225 1.739
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.018238 1.739
R-HSA-9700645 ALK mutants bind TKIs 0.019550 1.709
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.022682 1.644
R-HSA-162582 Signal Transduction 0.022607 1.646
R-HSA-6802957 Oncogenic MAPK signaling 0.025903 1.587
R-HSA-5602566 TICAM1 deficiency - HSE 0.034780 1.459
R-HSA-5602571 TRAF3 deficiency - HSE 0.051715 1.286
R-HSA-5674404 PTEN Loss of Function in Cancer 0.051715 1.286
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 0.084703 1.072
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 0.100765 0.997
R-HSA-1306955 GRB7 events in ERBB2 signaling 0.100765 0.997
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.116547 0.933
R-HSA-5603029 IkBA variant leads to EDA-ID 0.132052 0.879
R-HSA-5688849 Defective CSF2RB causes SMDP5 0.132052 0.879
R-HSA-5688890 Defective CSF2RA causes SMDP4 0.132052 0.879
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.132052 0.879
R-HSA-9861559 PDH complex synthesizes acetyl-CoA from PYR 0.037049 1.431
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.147286 0.832
R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 0.147286 0.832
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 0.147286 0.832
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.147286 0.832
R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15 0.147286 0.832
R-HSA-3656225 Defective CHST6 causes MCDC1 0.147286 0.832
R-HSA-8948747 Regulation of PTEN localization 0.162254 0.790
R-HSA-2562578 TRIF-mediated programmed cell death 0.162254 0.790
R-HSA-9732724 IFNG signaling activates MAPKs 0.162254 0.790
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 0.162254 0.790
R-HSA-444257 RSK activation 0.176960 0.752
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.176960 0.752
R-HSA-196025 Formation of annular gap junctions 0.176960 0.752
R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 0.176960 0.752
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.176960 0.752
R-HSA-9613354 Lipophagy 0.191409 0.718
R-HSA-9020958 Interleukin-21 signaling 0.191409 0.718
R-HSA-190873 Gap junction degradation 0.191409 0.718
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 0.205605 0.687
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.219552 0.658
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.044182 1.355
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.233256 0.632
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.233256 0.632
R-HSA-9656223 Signaling by RAF1 mutants 0.057297 1.242
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.128208 0.892
R-HSA-9649948 Signaling downstream of RAS mutants 0.072032 1.142
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.072032 1.142
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.072032 1.142
R-HSA-177504 Retrograde neurotrophin signalling 0.272944 0.564
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.041918 1.378
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.285714 0.544
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.285714 0.544
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.285714 0.544
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.285714 0.544
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.298259 0.525
R-HSA-5083636 Defective GALNT12 causes CRCS1 0.298259 0.525
R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 0.298259 0.525
R-HSA-5083625 Defective GALNT3 causes HFTC 0.298259 0.525
R-HSA-1296072 Voltage gated Potassium channels 0.183477 0.736
R-HSA-5083632 Defective C1GALT1C1 causes TNPS 0.322696 0.491
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.346284 0.461
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.221942 0.654
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.357769 0.446
R-HSA-163210 Formation of ATP by chemiosmotic coupling 0.357769 0.446
R-HSA-383280 Nuclear Receptor transcription pathway 0.196390 0.707
R-HSA-5658442 Regulation of RAS by GAPs 0.274012 0.562
R-HSA-912526 Interleukin receptor SHC signaling 0.401735 0.396
R-HSA-977068 Termination of O-glycan biosynthesis 0.401735 0.396
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.338794 0.470
R-HSA-9615710 Late endosomal microautophagy 0.462122 0.335
R-HSA-72689 Formation of a pool of free 40S subunits 0.289706 0.538
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.356923 0.447
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.356923 0.447
R-HSA-5578749 Transcriptional regulation by small RNAs 0.413995 0.383
R-HSA-8943723 Regulation of PTEN mRNA translation 0.094116 1.026
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.237201 0.625
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.237201 0.625
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.432729 0.364
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.233256 0.632
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.310585 0.508
R-HSA-5674135 MAP2K and MAPK activation 0.057297 1.242
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.237201 0.625
R-HSA-6802949 Signaling by RAS mutants 0.072032 1.142
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.045235 1.345
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 0.176960 0.752
R-HSA-9839394 TGFBR3 expression 0.105163 0.978
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.310585 0.508
R-HSA-6803529 FGFR2 alternative splicing 0.391033 0.408
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.294495 0.531
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.054541 1.263
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 0.116547 0.933
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.116547 0.933
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.176960 0.752
R-HSA-2025928 Calcineurin activates NFAT 0.191409 0.718
R-HSA-5673000 RAF activation 0.037128 1.430
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.272944 0.564
R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 0.334594 0.475
R-HSA-156842 Eukaryotic Translation Elongation 0.270619 0.568
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.099596 1.002
R-HSA-72613 Eukaryotic Translation Initiation 0.404500 0.393
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.191331 0.718
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.041064 1.387
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.045235 1.345
R-HSA-5221030 TET1,2,3 and TDG demethylate DNA 0.205605 0.687
R-HSA-9930044 Nuclear RNA decay 0.152291 0.817
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.442700 0.354
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 0.191409 0.718
R-HSA-9733709 Cardiogenesis 0.152291 0.817
R-HSA-72737 Cap-dependent Translation Initiation 0.404500 0.393
R-HSA-9839397 TGFBR3 regulates FGF2 signaling 0.051715 1.286
R-HSA-9708296 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 0.068355 1.165
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 0.068355 1.165
R-HSA-68689 CDC6 association with the ORC:origin complex 0.132052 0.879
R-HSA-209931 Serotonin and melatonin biosynthesis 0.049554 1.305
R-HSA-9032845 Activated NTRK2 signals through CDK5 0.162254 0.790
R-HSA-5576890 Phase 3 - rapid repolarisation 0.162254 0.790
R-HSA-190370 FGFR1b ligand binding and activation 0.176960 0.752
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 0.191409 0.718
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.205605 0.687
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 0.219552 0.658
R-HSA-75896 Plasmalogen biosynthesis 0.233256 0.632
R-HSA-209560 NF-kB is activated and signals survival 0.233256 0.632
R-HSA-8866427 VLDLR internalisation and degradation 0.246720 0.608
R-HSA-1482883 Acyl chain remodeling of DAG and TAG 0.259948 0.585
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.164642 0.783
R-HSA-432720 Lysosome Vesicle Biogenesis 0.177162 0.752
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.196201 0.707
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.334594 0.475
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.334594 0.475
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.380140 0.420
R-HSA-437239 Recycling pathway of L1 0.254447 0.594
R-HSA-350054 Notch-HLH transcription pathway 0.391033 0.408
R-HSA-933542 TRAF6 mediated NF-kB activation 0.412249 0.385
R-HSA-8949613 Cristae formation 0.442700 0.354
R-HSA-69615 G1/S DNA Damage Checkpoints 0.357928 0.446
R-HSA-9613829 Chaperone Mediated Autophagy 0.334594 0.475
R-HSA-202433 Generation of second messenger molecules 0.202604 0.693
R-HSA-201451 Signaling by BMP 0.442700 0.354
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.401733 0.396
R-HSA-170968 Frs2-mediated activation 0.259948 0.585
R-HSA-212165 Epigenetic regulation of gene expression 0.086622 1.062
R-HSA-5673001 RAF/MAP kinase cascade 0.308263 0.511
R-HSA-211000 Gene Silencing by RNA 0.352129 0.453
R-HSA-169893 Prolonged ERK activation events 0.298259 0.525
R-HSA-166166 MyD88-independent TLR4 cascade 0.366496 0.436
R-HSA-9734767 Developmental Cell Lineages 0.237792 0.624
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.342530 0.465
R-HSA-5684996 MAPK1/MAPK3 signaling 0.327946 0.484
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.162254 0.790
R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.298259 0.525
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.412249 0.385
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.366496 0.436
R-HSA-9839373 Signaling by TGFBR3 0.072032 1.142
R-HSA-2132295 MHC class II antigen presentation 0.437204 0.359
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.105163 0.978
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.413995 0.383
R-HSA-9754189 Germ layer formation at gastrulation 0.346284 0.461
R-HSA-1268020 Mitochondrial protein import 0.351571 0.454
R-HSA-5683057 MAPK family signaling cascades 0.119739 0.922
R-HSA-187706 Signalling to p38 via RIT and RIN 0.132052 0.879
R-HSA-170984 ARMS-mediated activation 0.191409 0.718
R-HSA-9706019 RHOBTB3 ATPase cycle 0.219552 0.658
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.233256 0.632
R-HSA-190373 FGFR1c ligand binding and activation 0.259948 0.585
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 0.128208 0.892
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.272944 0.564
R-HSA-176187 Activation of ATR in response to replication stress 0.152291 0.817
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.310585 0.508
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.322696 0.491
R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 0.357769 0.446
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.369054 0.433
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.254447 0.594
R-HSA-420029 Tight junction interactions 0.422579 0.374
R-HSA-1474165 Reproduction 0.260106 0.585
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.432729 0.364
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.105163 0.978
R-HSA-202403 TCR signaling 0.067428 1.171
R-HSA-2980766 Nuclear Envelope Breakdown 0.319489 0.496
R-HSA-9033241 Peroxisomal protein import 0.332376 0.478
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 0.176960 0.752
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.147286 0.832
R-HSA-392517 Rap1 signalling 0.068194 1.166
R-HSA-5687613 Diseases associated with surfactant metabolism 0.246720 0.608
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.272944 0.564
R-HSA-9022692 Regulation of MECP2 expression and activity 0.152291 0.817
R-HSA-190242 FGFR1 ligand binding and activation 0.334594 0.475
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.202604 0.693
R-HSA-5260271 Diseases of Immune System 0.202604 0.693
R-HSA-2022857 Keratan sulfate degradation 0.357769 0.446
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.442700 0.354
R-HSA-5334118 DNA methylation 0.462122 0.335
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.063342 1.198
R-HSA-9861718 Regulation of pyruvate metabolism 0.072032 1.142
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.068960 1.161
R-HSA-877300 Interferon gamma signaling 0.382620 0.417
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.151935 0.818
R-HSA-5619507 Activation of HOX genes during differentiation 0.151935 0.818
R-HSA-199991 Membrane Trafficking 0.299125 0.524
R-HSA-5660668 CLEC7A/inflammasome pathway 0.132052 0.879
R-HSA-199920 CREB phosphorylation 0.147286 0.832
R-HSA-9839389 TGFBR3 regulates TGF-beta signaling 0.162254 0.790
R-HSA-425986 Sodium/Proton exchangers 0.176960 0.752
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.191409 0.718
R-HSA-877312 Regulation of IFNG signaling 0.246720 0.608
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.259948 0.585
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.164642 0.783
R-HSA-113510 E2F mediated regulation of DNA replication 0.346284 0.461
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 0.412249 0.385
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.325941 0.487
R-HSA-9609507 Protein localization 0.358724 0.445
R-HSA-5621481 C-type lectin receptors (CLRs) 0.433949 0.363
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 0.205605 0.687
R-HSA-430116 GP1b-IX-V activation signalling 0.191409 0.718
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 0.298259 0.525
R-HSA-9664420 Killing mechanisms 0.298259 0.525
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.346284 0.461
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.376859 0.424
R-HSA-9612973 Autophagy 0.370679 0.431
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.158444 0.800
R-HSA-9006931 Signaling by Nuclear Receptors 0.240661 0.619
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.346781 0.460
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.461724 0.336
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.116547 0.933
R-HSA-448706 Interleukin-1 processing 0.191409 0.718
R-HSA-193692 Regulated proteolysis of p75NTR 0.191409 0.718
R-HSA-3000157 Laminin interactions 0.105163 0.978
R-HSA-8983711 OAS antiviral response 0.246720 0.608
R-HSA-9005895 Pervasive developmental disorders 0.246720 0.608
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.246720 0.608
R-HSA-9697154 Disorders of Nervous System Development 0.246720 0.608
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.272944 0.564
R-HSA-446353 Cell-extracellular matrix interactions 0.285714 0.544
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.152291 0.817
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 0.322696 0.491
R-HSA-6811438 Intra-Golgi traffic 0.215477 0.667
R-HSA-5620916 VxPx cargo-targeting to cilium 0.357769 0.446
R-HSA-8848584 Wax and plasmalogen biosynthesis 0.357769 0.446
R-HSA-5687128 MAPK6/MAPK4 signaling 0.228317 0.641
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.420079 0.377
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.444085 0.353
R-HSA-69206 G1/S Transition 0.451017 0.346
R-HSA-70268 Pyruvate metabolism 0.242291 0.616
R-HSA-3928662 EPHB-mediated forward signaling 0.234915 0.629
R-HSA-5362517 Signaling by Retinoic Acid 0.033742 1.472
R-HSA-4839726 Chromatin organization 0.107841 0.967
R-HSA-9006936 Signaling by TGFB family members 0.040747 1.390
R-HSA-451927 Interleukin-2 family signaling 0.202604 0.693
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.146187 0.835
R-HSA-1295596 Spry regulation of FGF signaling 0.285714 0.544
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.285714 0.544
R-HSA-9768759 Regulation of NPAS4 gene expression 0.322696 0.491
R-HSA-3214841 PKMTs methylate histone lysines 0.209030 0.680
R-HSA-449836 Other interleukin signaling 0.346284 0.461
R-HSA-9842860 Regulation of endogenous retroelements 0.323306 0.490
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.152291 0.817
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.073164 1.136
R-HSA-9671555 Signaling by PDGFR in disease 0.083436 1.079
R-HSA-5578768 Physiological factors 0.272944 0.564
R-HSA-9018681 Biosynthesis of protectins 0.272944 0.564
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.298259 0.525
R-HSA-9675151 Disorders of Developmental Biology 0.310585 0.508
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.334594 0.475
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.442700 0.354
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.112094 0.950
R-HSA-1632852 Macroautophagy 0.307030 0.513
R-HSA-193639 p75NTR signals via NF-kB 0.285714 0.544
R-HSA-9758941 Gastrulation 0.176438 0.753
R-HSA-168255 Influenza Infection 0.274786 0.561
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.128687 0.890
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.183066 0.737
R-HSA-9020956 Interleukin-27 signaling 0.205605 0.687
R-HSA-8964038 LDL clearance 0.391033 0.408
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.401735 0.396
R-HSA-5689880 Ub-specific processing proteases 0.128004 0.893
R-HSA-69202 Cyclin E associated events during G1/S transition 0.401733 0.396
R-HSA-446728 Cell junction organization 0.085531 1.068
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins 0.132052 0.879
R-HSA-6814848 Glycerophospholipid catabolism 0.272944 0.564
R-HSA-9027307 Biosynthesis of maresin-like SPMs 0.310585 0.508
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.322696 0.491
R-HSA-198753 ERK/MAPK targets 0.369054 0.433
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.380140 0.420
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.232958 0.633
R-HSA-2682334 EPH-Ephrin signaling 0.270619 0.568
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.452497 0.344
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.462122 0.335
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.462122 0.335
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.413905 0.383
R-HSA-3247509 Chromatin modifying enzymes 0.166828 0.778
R-HSA-3214858 RMTs methylate histone arginines 0.234915 0.629
R-HSA-156711 Polo-like kinase mediated events 0.063342 1.198
R-HSA-1500931 Cell-Cell communication 0.145105 0.838
R-HSA-9683686 Maturation of spike protein 0.205605 0.687
R-HSA-389599 Alpha-oxidation of phytanate 0.422579 0.374
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.462122 0.335
R-HSA-2559580 Oxidative Stress Induced Senescence 0.323306 0.490
R-HSA-2559583 Cellular Senescence 0.278151 0.556
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.332907 0.478
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.254795 0.594
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.254795 0.594
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.395051 0.403
R-HSA-166520 Signaling by NTRKs 0.076760 1.115
R-HSA-1266738 Developmental Biology 0.249415 0.603
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.272944 0.564
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 0.298259 0.525
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.351571 0.454
R-HSA-1592230 Mitochondrial biogenesis 0.409208 0.388
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.299289 0.524
R-HSA-421270 Cell-cell junction organization 0.348041 0.458
R-HSA-5654738 Signaling by FGFR2 0.461724 0.336
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.437204 0.359
R-HSA-418990 Adherens junctions interactions 0.412860 0.384
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.169999 0.770
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 0.391033 0.408
R-HSA-5654736 Signaling by FGFR1 0.105900 0.975
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.083436 1.079
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.259948 0.585
R-HSA-210991 Basigin interactions 0.369054 0.433
R-HSA-9865881 Complex III assembly 0.412249 0.385
R-HSA-73614 Pyrimidine salvage 0.452497 0.344
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.356923 0.447
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.313024 0.504
R-HSA-209776 Metabolism of amine-derived hormones 0.313024 0.504
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.209942 0.678
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.099596 1.002
R-HSA-8863678 Neurodegenerative Diseases 0.099596 1.002
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.432729 0.364
R-HSA-8986944 Transcriptional Regulation by MECP2 0.261129 0.583
R-HSA-5688426 Deubiquitination 0.360529 0.443
R-HSA-9007101 Rab regulation of trafficking 0.409208 0.388
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.116539 0.934
R-HSA-418885 DCC mediated attractive signaling 0.285714 0.544
R-HSA-8853659 RET signaling 0.177162 0.752
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.334594 0.475
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.169999 0.770
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.193068 0.714
R-HSA-422475 Axon guidance 0.303170 0.518
R-HSA-9645723 Diseases of programmed cell death 0.246980 0.607
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.361712 0.442
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.442700 0.354
R-HSA-8984722 Interleukin-35 Signalling 0.246720 0.608
R-HSA-9018682 Biosynthesis of maresins 0.401735 0.396
R-HSA-5669034 TNFs bind their physiological receptors 0.412249 0.385
R-HSA-9675108 Nervous system development 0.380905 0.419
R-HSA-1538133 G0 and Early G1 0.146187 0.835
R-HSA-1483257 Phospholipid metabolism 0.325121 0.488
R-HSA-210993 Tie2 Signaling 0.334594 0.475
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.391033 0.408
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.401733 0.396
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.380809 0.419
R-HSA-3000170 Syndecan interactions 0.094116 1.026
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.452497 0.344
R-HSA-177929 Signaling by EGFR 0.313024 0.504
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.401733 0.396
R-HSA-168316 Assembly of Viral Components at the Budding Site 0.116547 0.933
R-HSA-373752 Netrin-1 signaling 0.234915 0.629
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.432729 0.364
R-HSA-264876 Insulin processing 0.442700 0.354
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.088728 1.052
R-HSA-190236 Signaling by FGFR 0.129689 0.887
R-HSA-9694301 Maturation of replicase proteins 0.162254 0.790
R-HSA-844456 The NLRP3 inflammasome 0.346284 0.461
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.401735 0.396
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.100485 0.998
R-HSA-69242 S Phase 0.338798 0.470
R-HSA-9031628 NGF-stimulated transcription 0.260968 0.583
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.407879 0.389
R-HSA-447115 Interleukin-12 family signaling 0.242291 0.616
R-HSA-168268 Virus Assembly and Release 0.298259 0.525
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.332376 0.478
R-HSA-622312 Inflammasomes 0.452497 0.344
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 0.334594 0.475
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.370573 0.431
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.325941 0.487
R-HSA-1433557 Signaling by SCF-KIT 0.228422 0.641
R-HSA-9020591 Interleukin-12 signaling 0.438134 0.358
R-HSA-192105 Synthesis of bile acids and bile salts 0.308888 0.510
R-HSA-194068 Bile acid and bile salt metabolism 0.366496 0.436
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.471579 0.326
R-HSA-68962 Activation of the pre-replicative complex 0.471579 0.326
R-HSA-2424491 DAP12 signaling 0.471579 0.326
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.471579 0.326
R-HSA-114452 Activation of BH3-only proteins 0.471579 0.326
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.473301 0.325
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.480870 0.318
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.480870 0.318
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.480870 0.318
R-HSA-186763 Downstream signal transduction 0.480870 0.318
R-HSA-182971 EGFR downregulation 0.480870 0.318
R-HSA-9843745 Adipogenesis 0.482687 0.316
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.484727 0.315
R-HSA-69275 G2/M Transition 0.491613 0.308
R-HSA-1855170 IPs transport between nucleus and cytosol 0.498966 0.302
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.498966 0.302
R-HSA-2022854 Keratan sulfate biosynthesis 0.498966 0.302
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.498966 0.302
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.498966 0.302
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.498966 0.302
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.498966 0.302
R-HSA-1839124 FGFR1 mutant receptor activation 0.498966 0.302
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.498966 0.302
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.498966 0.302
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.498966 0.302
R-HSA-453274 Mitotic G2-G2/M phases 0.499126 0.302
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.501575 0.300
R-HSA-438064 Post NMDA receptor activation events 0.507113 0.295
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.507777 0.294
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.507777 0.294
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.507777 0.294
R-HSA-5223345 Miscellaneous transport and binding events 0.507777 0.294
R-HSA-9018519 Estrogen-dependent gene expression 0.509130 0.293
R-HSA-168898 Toll-like Receptor Cascades 0.510305 0.292
R-HSA-156902 Peptide chain elongation 0.512610 0.290
R-HSA-9663891 Selective autophagy 0.512610 0.290
R-HSA-180746 Nuclear import of Rev protein 0.516434 0.287
R-HSA-901042 Calnexin/calreticulin cycle 0.516434 0.287
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.516434 0.287
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.516434 0.287
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.516434 0.287
R-HSA-5205647 Mitophagy 0.516434 0.287
R-HSA-6807070 PTEN Regulation 0.522085 0.282
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.523482 0.281
R-HSA-202424 Downstream TCR signaling 0.523482 0.281
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.524938 0.280
R-HSA-187687 Signalling to ERKs 0.524938 0.280
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.524938 0.280
R-HSA-2559585 Oncogene Induced Senescence 0.524938 0.280
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.524938 0.280
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.528857 0.277
R-HSA-212300 PRC2 methylates histones and DNA 0.533294 0.273
R-HSA-6804757 Regulation of TP53 Degradation 0.533294 0.273
R-HSA-111933 Calmodulin induced events 0.533294 0.273
R-HSA-111997 CaM pathway 0.533294 0.273
R-HSA-163560 Triglyceride catabolism 0.533294 0.273
R-HSA-69205 G1/S-Specific Transcription 0.533294 0.273
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.534191 0.272
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.541504 0.266
R-HSA-419037 NCAM1 interactions 0.541504 0.266
R-HSA-5689896 Ovarian tumor domain proteases 0.541504 0.266
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.549569 0.260
R-HSA-9837999 Mitochondrial protein degradation 0.549944 0.260
R-HSA-1474290 Collagen formation 0.549944 0.260
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.555112 0.256
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.555698 0.255
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.557493 0.254
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.557493 0.254
R-HSA-69541 Stabilization of p53 0.557493 0.254
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.557493 0.254
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.557493 0.254
R-HSA-8964043 Plasma lipoprotein clearance 0.557493 0.254
R-HSA-201556 Signaling by ALK 0.557493 0.254
R-HSA-1852241 Organelle biogenesis and maintenance 0.558870 0.253
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.560237 0.252
R-HSA-72764 Eukaryotic Translation Termination 0.560237 0.252
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.563879 0.249
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.565278 0.248
R-HSA-177243 Interactions of Rev with host cellular proteins 0.565278 0.248
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.565278 0.248
R-HSA-1251985 Nuclear signaling by ERBB4 0.565278 0.248
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.565278 0.248
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 0.565278 0.248
R-HSA-6807878 COPI-mediated anterograde transport 0.565320 0.248
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.565320 0.248
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.565320 0.248
R-HSA-1296071 Potassium Channels 0.565320 0.248
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.572927 0.242
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.572927 0.242
R-HSA-5423646 Aflatoxin activation and detoxification 0.572927 0.242
R-HSA-8853884 Transcriptional Regulation by VENTX 0.572927 0.242
R-HSA-9694548 Maturation of spike protein 0.572927 0.242
R-HSA-9607240 FLT3 Signaling 0.572927 0.242
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.575360 0.240
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.575360 0.240
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.575360 0.240
R-HSA-3214847 HATs acetylate histones 0.580316 0.236
R-HSA-5655302 Signaling by FGFR1 in disease 0.580441 0.236
R-HSA-9683701 Translation of Structural Proteins 0.580441 0.236
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.587824 0.231
R-HSA-379716 Cytosolic tRNA aminoacylation 0.587824 0.231
R-HSA-111996 Ca-dependent events 0.587824 0.231
R-HSA-2408557 Selenocysteine synthesis 0.590102 0.229
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.591782 0.228
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.594930 0.226
R-HSA-9710421 Defective pyroptosis 0.595077 0.225
R-HSA-5654743 Signaling by FGFR4 0.595077 0.225
R-HSA-192823 Viral mRNA Translation 0.599717 0.222
R-HSA-2172127 DAP12 interactions 0.602203 0.220
R-HSA-190828 Gap junction trafficking 0.602203 0.220
R-HSA-156581 Methylation 0.602203 0.220
R-HSA-5683826 Surfactant metabolism 0.602203 0.220
R-HSA-9711097 Cellular response to starvation 0.603383 0.219
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.604460 0.219
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.604460 0.219
R-HSA-5653656 Vesicle-mediated transport 0.609196 0.215
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.609205 0.215
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.609205 0.215
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.609205 0.215
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.609205 0.215
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.609205 0.215
R-HSA-1489509 DAG and IP3 signaling 0.609205 0.215
R-HSA-5654741 Signaling by FGFR3 0.609205 0.215
R-HSA-5633007 Regulation of TP53 Activity 0.610996 0.214
R-HSA-74160 Gene expression (Transcription) 0.613669 0.212
R-HSA-5696398 Nucleotide Excision Repair 0.613820 0.212
R-HSA-5357905 Regulation of TNFR1 signaling 0.616083 0.210
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.616083 0.210
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.616083 0.210
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.616083 0.210
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.616083 0.210
R-HSA-9006925 Intracellular signaling by second messengers 0.619656 0.208
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.622841 0.206
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.622841 0.206
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.623010 0.206
R-HSA-2408522 Selenoamino acid metabolism 0.625928 0.203
R-HSA-2672351 Stimuli-sensing channels 0.627542 0.202
R-HSA-389356 Co-stimulation by CD28 0.629480 0.201
R-HSA-425410 Metal ion SLC transporters 0.629480 0.201
R-HSA-8878171 Transcriptional regulation by RUNX1 0.634293 0.198
R-HSA-1638074 Keratan sulfate/keratin metabolism 0.636002 0.197
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.636002 0.197
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.636002 0.197
R-HSA-157858 Gap junction trafficking and regulation 0.636002 0.197
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.636002 0.197
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.636002 0.197
R-HSA-109704 PI3K Cascade 0.642411 0.192
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.645246 0.190
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.645246 0.190
R-HSA-1483249 Inositol phosphate metabolism 0.645246 0.190
R-HSA-1169091 Activation of NF-kappaB in B cells 0.648706 0.188
R-HSA-68949 Orc1 removal from chromatin 0.654892 0.184
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.654892 0.184
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.654892 0.184
R-HSA-1257604 PIP3 activates AKT signaling 0.656432 0.183
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.658071 0.182
R-HSA-8948751 Regulation of PTEN stability and activity 0.660969 0.180
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.660969 0.180
R-HSA-9639288 Amino acids regulate mTORC1 0.660969 0.180
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.666435 0.176
R-HSA-909733 Interferon alpha/beta signaling 0.666435 0.176
R-HSA-72649 Translation initiation complex formation 0.666939 0.176
R-HSA-8939211 ESR-mediated signaling 0.667894 0.175
R-HSA-9678108 SARS-CoV-1 Infection 0.668334 0.175
R-HSA-373760 L1CAM interactions 0.670548 0.174
R-HSA-3214815 HDACs deacetylate histones 0.672804 0.172
R-HSA-72702 Ribosomal scanning and start codon recognition 0.678567 0.168
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.678567 0.168
R-HSA-75893 TNF signaling 0.678567 0.168
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.678567 0.168
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.682643 0.166
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.682643 0.166
R-HSA-112399 IRS-mediated signalling 0.684228 0.165
R-HSA-5621480 Dectin-2 family 0.684228 0.165
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.684228 0.165
R-HSA-68875 Mitotic Prophase 0.686594 0.163
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.689790 0.161
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.689790 0.161
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.694374 0.158
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.694374 0.158
R-HSA-191859 snRNP Assembly 0.695254 0.158
R-HSA-194441 Metabolism of non-coding RNA 0.695254 0.158
R-HSA-429914 Deadenylation-dependent mRNA decay 0.695254 0.158
R-HSA-8979227 Triglyceride metabolism 0.695254 0.158
R-HSA-8943724 Regulation of PTEN gene transcription 0.700623 0.155
R-HSA-379724 tRNA Aminoacylation 0.700623 0.155
R-HSA-983189 Kinesins 0.700623 0.155
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.700623 0.155
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.700623 0.155
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.700623 0.155
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.700623 0.155
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.700623 0.155
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.700623 0.155
R-HSA-1227986 Signaling by ERBB2 0.700623 0.155
R-HSA-162909 Host Interactions of HIV factors 0.701995 0.154
R-HSA-977606 Regulation of Complement cascade 0.705746 0.151
R-HSA-73856 RNA Polymerase II Transcription Termination 0.705897 0.151
R-HSA-168325 Viral Messenger RNA Synthesis 0.705897 0.151
R-HSA-112043 PLC beta mediated events 0.705897 0.151
R-HSA-2428928 IRS-related events triggered by IGF1R 0.705897 0.151
R-HSA-450294 MAP kinase activation 0.705897 0.151
R-HSA-8956321 Nucleotide salvage 0.705897 0.151
R-HSA-1280218 Adaptive Immune System 0.706770 0.151
R-HSA-9707616 Heme signaling 0.711078 0.148
R-HSA-6784531 tRNA processing in the nucleus 0.711078 0.148
R-HSA-375165 NCAM signaling for neurite out-growth 0.711078 0.148
R-HSA-186797 Signaling by PDGF 0.711078 0.148
R-HSA-983712 Ion channel transport 0.713254 0.147
R-HSA-69278 Cell Cycle, Mitotic 0.713845 0.146
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.716169 0.145
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.716169 0.145
R-HSA-5617833 Cilium Assembly 0.716276 0.145
R-HSA-69481 G2/M Checkpoints 0.716763 0.145
R-HSA-388841 Regulation of T cell activation by CD28 family 0.720822 0.142
R-HSA-211981 Xenobiotics 0.721170 0.142
R-HSA-2428924 IGF1R signaling cascade 0.721170 0.142
R-HSA-936837 Ion transport by P-type ATPases 0.721170 0.142
R-HSA-74751 Insulin receptor signalling cascade 0.721170 0.142
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.721170 0.142
R-HSA-69620 Cell Cycle Checkpoints 0.726014 0.139
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.726084 0.139
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.727433 0.138
R-HSA-8854518 AURKA Activation by TPX2 0.730911 0.136
R-HSA-5576891 Cardiac conduction 0.734357 0.134
R-HSA-112040 G-protein mediated events 0.735653 0.133
R-HSA-9909396 Circadian clock 0.737762 0.132
R-HSA-8856688 Golgi-to-ER retrograde transport 0.737762 0.132
R-HSA-913709 O-linked glycosylation of mucins 0.740312 0.131
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.740312 0.131
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.740312 0.131
R-HSA-389948 Co-inhibition by PD-1 0.745155 0.128
R-HSA-448424 Interleukin-17 signaling 0.749386 0.125
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.753350 0.123
R-HSA-376176 Signaling by ROBO receptors 0.753350 0.123
R-HSA-427413 NoRC negatively regulates rRNA expression 0.753804 0.123
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.753804 0.123
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.753804 0.123
R-HSA-453276 Regulation of mitotic cell cycle 0.753804 0.123
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.753804 0.123
R-HSA-3858494 Beta-catenin independent WNT signaling 0.754236 0.122
R-HSA-3700989 Transcriptional Regulation by TP53 0.758599 0.120
R-HSA-9948299 Ribosome-associated quality control 0.760573 0.119
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.762408 0.118
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.762408 0.118
R-HSA-69052 Switching of origins to a post-replicative state 0.762408 0.118
R-HSA-4086398 Ca2+ pathway 0.762408 0.118
R-HSA-1236394 Signaling by ERBB4 0.766597 0.115
R-HSA-1226099 Signaling by FGFR in disease 0.766597 0.115
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.766826 0.115
R-HSA-380287 Centrosome maturation 0.770713 0.113
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.770713 0.113
R-HSA-1169408 ISG15 antiviral mechanism 0.770713 0.113
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.770713 0.113
R-HSA-71403 Citric acid cycle (TCA cycle) 0.770713 0.113
R-HSA-1980143 Signaling by NOTCH1 0.774756 0.111
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.775800 0.110
R-HSA-9694635 Translation of Structural Proteins 0.778728 0.109
R-HSA-8856828 Clathrin-mediated endocytosis 0.778742 0.109
R-HSA-4086400 PCP/CE pathway 0.782630 0.106
R-HSA-216083 Integrin cell surface interactions 0.782630 0.106
R-HSA-166658 Complement cascade 0.784526 0.105
R-HSA-9659379 Sensory processing of sound 0.786464 0.104
R-HSA-68882 Mitotic Anaphase 0.788831 0.103
R-HSA-199977 ER to Golgi Anterograde Transport 0.790176 0.102
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.790230 0.102
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.791196 0.102
R-HSA-977225 Amyloid fiber formation 0.793930 0.100
R-HSA-9018677 Biosynthesis of DHA-derived SPMs 0.793930 0.100
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.797565 0.098
R-HSA-9707564 Cytoprotection by HMOX1 0.801137 0.096
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.801137 0.096
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.803736 0.095
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.804645 0.094
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.804645 0.094
R-HSA-390918 Peroxisomal lipid metabolism 0.804645 0.094
R-HSA-6794362 Protein-protein interactions at synapses 0.808092 0.093
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.808939 0.092
R-HSA-72766 Translation 0.809366 0.092
R-HSA-141424 Amplification of signal from the kinetochores 0.811478 0.091
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.811478 0.091
R-HSA-1989781 PPARA activates gene expression 0.811494 0.091
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.814804 0.089
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.816514 0.088
R-HSA-390466 Chaperonin-mediated protein folding 0.818073 0.087
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.818978 0.087
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.821283 0.086
R-HSA-73857 RNA Polymerase II Transcription 0.823604 0.084
R-HSA-73884 Base Excision Repair 0.827536 0.082
R-HSA-373080 Class B/2 (Secretin family receptors) 0.827536 0.082
R-HSA-109581 Apoptosis 0.828544 0.082
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.830580 0.081
R-HSA-1640170 Cell Cycle 0.833756 0.079
R-HSA-388396 GPCR downstream signalling 0.835594 0.078
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.836509 0.078
R-HSA-391251 Protein folding 0.836509 0.078
R-HSA-74752 Signaling by Insulin receptor 0.836509 0.078
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.836509 0.078
R-HSA-68867 Assembly of the pre-replicative complex 0.839395 0.076
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.842231 0.075
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.843683 0.074
R-HSA-913531 Interferon Signaling 0.843683 0.074
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.845016 0.073
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.848426 0.071
R-HSA-5389840 Mitochondrial translation elongation 0.850441 0.070
R-HSA-418555 G alpha (s) signalling events 0.850501 0.070
R-HSA-372790 Signaling by GPCR 0.855672 0.068
R-HSA-8957275 Post-translational protein phosphorylation 0.855677 0.068
R-HSA-5368286 Mitochondrial translation initiation 0.855677 0.068
R-HSA-212436 Generic Transcription Pathway 0.857806 0.067
R-HSA-69618 Mitotic Spindle Checkpoint 0.860730 0.065
R-HSA-70171 Glycolysis 0.860730 0.065
R-HSA-9009391 Extra-nuclear estrogen signaling 0.863190 0.064
R-HSA-9020702 Interleukin-1 signaling 0.863190 0.064
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.865607 0.063
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.867981 0.061
R-HSA-111885 Opioid Signalling 0.870314 0.060
R-HSA-9860931 Response of endothelial cells to shear stress 0.870314 0.060
R-HSA-3781865 Diseases of glycosylation 0.875222 0.058
R-HSA-9692914 SARS-CoV-1-host interactions 0.877068 0.057
R-HSA-1280215 Cytokine Signaling in Immune system 0.877470 0.057
R-HSA-69239 Synthesis of DNA 0.879240 0.056
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.882037 0.055
R-HSA-5419276 Mitochondrial translation termination 0.883471 0.054
R-HSA-69002 DNA Replication Pre-Initiation 0.883471 0.054
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.883471 0.054
R-HSA-449147 Signaling by Interleukins 0.887583 0.052
R-HSA-2871796 FCERI mediated MAPK activation 0.889542 0.051
R-HSA-68877 Mitotic Prometaphase 0.890074 0.051
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.891494 0.050
R-HSA-72163 mRNA Splicing - Major Pathway 0.891619 0.050
R-HSA-9694516 SARS-CoV-2 Infection 0.893001 0.049
R-HSA-9855142 Cellular responses to mechanical stimuli 0.893413 0.049
R-HSA-9609690 HCMV Early Events 0.894650 0.048
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.895297 0.048
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.900035 0.046
R-HSA-9658195 Leishmania infection 0.902491 0.045
R-HSA-9824443 Parasitic Infection Pathways 0.902491 0.045
R-HSA-70326 Glucose metabolism 0.902509 0.045
R-HSA-2980736 Peptide hormone metabolism 0.902509 0.045
R-HSA-948021 Transport to the Golgi and subsequent modification 0.903276 0.044
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.903699 0.044
R-HSA-5693538 Homology Directed Repair 0.904233 0.044
R-HSA-72172 mRNA Splicing 0.907338 0.042
R-HSA-5357801 Programmed Cell Death 0.908657 0.042
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.909226 0.041
R-HSA-3371556 Cellular response to heat stress 0.909226 0.041
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.909226 0.041
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.912409 0.040
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.917406 0.037
R-HSA-397014 Muscle contraction 0.917406 0.037
R-HSA-195721 Signaling by WNT 0.921272 0.036
R-HSA-6798695 Neutrophil degranulation 0.926844 0.033
R-HSA-68886 M Phase 0.927390 0.033
R-HSA-162906 HIV Infection 0.933577 0.030
R-HSA-9705683 SARS-CoV-2-host interactions 0.934541 0.029
R-HSA-112316 Neuronal System 0.935089 0.029
R-HSA-5173105 O-linked glycosylation 0.935345 0.029
R-HSA-5368287 Mitochondrial translation 0.936490 0.028
R-HSA-72312 rRNA processing 0.938268 0.028
R-HSA-9664407 Parasite infection 0.938720 0.027
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.938720 0.027
R-HSA-9664417 Leishmania phagocytosis 0.938720 0.027
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.939806 0.027
R-HSA-162599 Late Phase of HIV Life Cycle 0.941920 0.026
R-HSA-202733 Cell surface interactions at the vascular wall 0.942644 0.026
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 0.942949 0.026
R-HSA-8957322 Metabolism of steroids 0.943693 0.025
R-HSA-2871837 FCERI mediated NF-kB activation 0.943960 0.025
R-HSA-157118 Signaling by NOTCH 0.945127 0.025
R-HSA-1474244 Extracellular matrix organization 0.948631 0.023
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.950553 0.022
R-HSA-2142753 Arachidonate metabolism 0.951430 0.022
R-HSA-446652 Interleukin-1 family signaling 0.951430 0.022
R-HSA-69306 DNA Replication 0.952291 0.021
R-HSA-5693532 DNA Double-Strand Break Repair 0.952291 0.021
R-HSA-9609646 HCMV Infection 0.952687 0.021
R-HSA-9610379 HCMV Late Events 0.955586 0.020
R-HSA-162587 HIV Life Cycle 0.955586 0.020
R-HSA-2467813 Separation of Sister Chromatids 0.960816 0.017
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.962865 0.016
R-HSA-5619102 SLC transporter disorders 0.962865 0.016
R-HSA-9711123 Cellular response to chemical stress 0.963861 0.016
R-HSA-72306 tRNA processing 0.965432 0.015
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.967822 0.014
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.968393 0.014
R-HSA-611105 Respiratory electron transport 0.970047 0.013
R-HSA-201681 TCF dependent signaling in response to WNT 0.972614 0.012
R-HSA-375276 Peptide ligand-binding receptors 0.974048 0.011
R-HSA-9679506 SARS-CoV Infections 0.976063 0.011
R-HSA-1630316 Glycosaminoglycan metabolism 0.977109 0.010
R-HSA-428157 Sphingolipid metabolism 0.980169 0.009
R-HSA-1483206 Glycerophospholipid biosynthesis 0.980868 0.008
R-HSA-597592 Post-translational protein modification 0.980973 0.008
R-HSA-392499 Metabolism of proteins 0.983995 0.007
R-HSA-112315 Transmission across Chemical Synapses 0.984419 0.007
R-HSA-446203 Asparagine N-linked glycosylation 0.985388 0.006
R-HSA-8953854 Metabolism of RNA 0.985520 0.006
R-HSA-556833 Metabolism of lipids 0.985659 0.006
R-HSA-5668914 Diseases of metabolism 0.986385 0.006
R-HSA-168256 Immune System 0.987917 0.005
R-HSA-71291 Metabolism of amino acids and derivatives 0.988943 0.005
R-HSA-2262752 Cellular responses to stress 0.989561 0.005
R-HSA-15869 Metabolism of nucleotides 0.989613 0.005
R-HSA-156580 Phase II - Conjugation of compounds 0.990159 0.004
R-HSA-168249 Innate Immune System 0.991129 0.004
R-HSA-73894 DNA Repair 0.991268 0.004
R-HSA-5619115 Disorders of transmembrane transporters 0.991478 0.004
R-HSA-416476 G alpha (q) signalling events 0.993725 0.003
R-HSA-76002 Platelet activation, signaling and aggregation 0.994760 0.002
R-HSA-211945 Phase I - Functionalization of compounds 0.995125 0.002
R-HSA-418594 G alpha (i) signalling events 0.995933 0.002
R-HSA-8978868 Fatty acid metabolism 0.995933 0.002
R-HSA-9824446 Viral Infection Pathways 0.996774 0.001
R-HSA-1643685 Disease 0.997101 0.001
R-HSA-8953897 Cellular responses to stimuli 0.997365 0.001
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.998129 0.001
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.999413 0.000
R-HSA-425407 SLC-mediated transmembrane transport 0.999445 0.000
R-HSA-109582 Hemostasis 0.999693 0.000
R-HSA-382551 Transport of small molecules 0.999710 0.000
R-HSA-500792 GPCR ligand binding 0.999797 0.000
R-HSA-211859 Biological oxidations 0.999944 0.000
R-HSA-5663205 Infectious disease 0.999975 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
PRKD2PRKD2 0.793 0.585 -3 0.597
SRPK2SRPK2 0.788 0.562 -3 0.771
PRKD3PRKD3 0.786 0.591 -3 0.648
SBKSBK 0.785 0.636 -3 0.835
MAPKAPK2MAPKAPK2 0.784 0.549 -3 0.654
CDKL5CDKL5 0.782 0.530 -3 0.621
AKT2AKT2 0.781 0.578 -3 0.745
RSK2RSK2 0.780 0.535 -3 0.653
RSK3RSK3 0.780 0.546 -3 0.650
MAPKAPK3MAPKAPK3 0.780 0.558 -3 0.564
SRPK1SRPK1 0.779 0.523 -3 0.691
PRKXPRKX 0.779 0.491 -3 0.689
PRKD1PRKD1 0.779 0.498 -3 0.488
P90RSKP90RSK 0.778 0.557 -3 0.653
SGK1SGK1 0.777 0.594 -3 0.814
AKT3AKT3 0.777 0.558 -3 0.803
CHK2CHK2 0.776 0.623 -3 0.768
HIPK4HIPK4 0.776 0.465 1 0.720
CDKL1CDKL1 0.775 0.597 -3 0.598
PKACAPKACA 0.774 0.462 -2 0.705
CAMK1ACAMK1A 0.774 0.565 -3 0.734
RSK4RSK4 0.774 0.504 -3 0.684
CAMK1DCAMK1D 0.774 0.565 -3 0.692
SIKSIK 0.773 0.501 -3 0.576
PIM1PIM1 0.773 0.539 -3 0.616
PKACBPKACB 0.773 0.443 -2 0.746
AMPKA2AMPKA2 0.772 0.495 -3 0.498
MSK2MSK2 0.771 0.516 -3 0.668
CLK1CLK1 0.769 0.476 -3 0.653
AKT1AKT1 0.769 0.515 -3 0.704
MSK1MSK1 0.769 0.469 -3 0.655
PIM2PIM2 0.768 0.547 -3 0.669
P70S6KBP70S6KB 0.768 0.497 -3 0.581
P70S6KP70S6K 0.768 0.529 -3 0.691
PIM3PIM3 0.767 0.486 -3 0.517
BRSK1BRSK1 0.767 0.414 -3 0.552
SRPK3SRPK3 0.767 0.490 -3 0.695
CLK4CLK4 0.766 0.474 -3 0.645
AMPKA1AMPKA1 0.765 0.454 -3 0.432
SGK3SGK3 0.763 0.469 -3 0.598
PKACGPKACG 0.763 0.388 -2 0.808
NUAK1NUAK1 0.763 0.439 -3 0.559
NDR1NDR1 0.762 0.388 -3 0.476
NDR2NDR2 0.762 0.328 -3 0.438
ICKICK 0.762 0.484 -3 0.529
QSKQSK 0.762 0.396 4 0.918
NUAK2NUAK2 0.761 0.435 -3 0.500
MAPKAPK5MAPKAPK5 0.761 0.541 -3 0.646
AURCAURC 0.761 0.280 -2 0.743
MELKMELK 0.761 0.440 -3 0.514
DYRK1ADYRK1A 0.760 0.429 1 0.671
CAMK1BCAMK1B 0.759 0.505 -3 0.448
CAMK1GCAMK1G 0.759 0.473 -3 0.624
MYLK4MYLK4 0.759 0.418 -2 0.830
PKN3PKN3 0.758 0.386 -3 0.489
PKG2PKG2 0.758 0.343 -2 0.752
BRSK2BRSK2 0.757 0.326 -3 0.464
CLK2CLK2 0.757 0.435 -3 0.681
CRIKCRIK 0.756 0.563 -3 0.721
PKN1PKN1 0.755 0.455 -3 0.662
LATS2LATS2 0.755 0.293 -5 0.815
TSSK1TSSK1 0.753 0.323 -3 0.410
PKG1PKG1 0.753 0.400 -2 0.680
HIPK2HIPK2 0.753 0.316 1 0.557
MRCKBMRCKB 0.753 0.489 -3 0.636
HIPK1HIPK1 0.753 0.365 1 0.652
AURBAURB 0.753 0.269 -2 0.736
CAMK4CAMK4 0.753 0.361 -3 0.458
DYRK3DYRK3 0.752 0.399 1 0.660
PHKG1PHKG1 0.751 0.335 -3 0.471
MAKMAK 0.751 0.424 -2 0.801
CAMK2ACAMK2A 0.749 0.329 2 0.158
PAK1PAK1 0.749 0.274 -2 0.841
HIPK3HIPK3 0.749 0.358 1 0.671
PKN2PKN2 0.748 0.310 -3 0.433
MOKMOK 0.748 0.459 1 0.681
DCAMKL1DCAMKL1 0.748 0.444 -3 0.553
CAMK2DCAMK2D 0.748 0.298 -3 0.418
PAK6PAK6 0.748 0.200 -2 0.764
SKMLCKSKMLCK 0.748 0.323 -2 0.890
CDC7CDC7 0.747 0.202 1 0.784
PAK3PAK3 0.747 0.258 -2 0.833
CAMLCKCAMLCK 0.747 0.404 -2 0.879
CLK3CLK3 0.747 0.273 1 0.743
DAPK2DAPK2 0.746 0.470 -3 0.412
MRCKAMRCKA 0.746 0.474 -3 0.603
PKCDPKCD 0.746 0.271 2 0.136
QIKQIK 0.746 0.313 -3 0.405
MARK4MARK4 0.745 0.220 4 0.920
DCAMKL2DCAMKL2 0.743 0.342 -3 0.521
DYRK2DYRK2 0.743 0.258 1 0.645
CHK1CHK1 0.743 0.324 -3 0.403
MNK2MNK2 0.742 0.204 -2 0.830
NIM1NIM1 0.741 0.223 3 0.813
CAMK2BCAMK2B 0.741 0.254 2 0.137
TSSK2TSSK2 0.741 0.234 -5 0.938
MARK3MARK3 0.741 0.248 4 0.888
PAK2PAK2 0.739 0.253 -2 0.828
PAK5PAK5 0.739 0.248 -2 0.716
SNRKSNRK 0.739 0.242 2 0.099
MARK1MARK1 0.739 0.261 4 0.901
SMMLCKSMMLCK 0.738 0.438 -3 0.526
ROCK2ROCK2 0.738 0.457 -3 0.557
DAPK3DAPK3 0.738 0.453 -3 0.568
PHKG2PHKG2 0.737 0.298 -3 0.494
PAK4PAK4 0.737 0.226 -2 0.726
MNK1MNK1 0.737 0.208 -2 0.841
WNK1WNK1 0.737 0.175 -2 0.888
MST4MST4 0.737 0.156 2 0.198
DMPK1DMPK1 0.737 0.465 -3 0.614
MARK2MARK2 0.737 0.231 4 0.863
DYRK1BDYRK1B 0.737 0.275 1 0.586
AURAAURA 0.736 0.223 -2 0.711
NIKNIK 0.736 0.354 -3 0.331
PKCBPKCB 0.735 0.218 2 0.104
PKCAPKCA 0.735 0.181 2 0.119
NLKNLK 0.735 0.116 1 0.762
RAF1RAF1 0.734 0.187 1 0.819
PKCTPKCT 0.733 0.277 2 0.100
PKCEPKCE 0.733 0.303 2 0.109
PKCGPKCG 0.733 0.193 2 0.107
ROCK1ROCK1 0.733 0.452 -3 0.605
DAPK1DAPK1 0.733 0.433 -3 0.604
SSTKSSTK 0.733 0.199 4 0.898
PKCHPKCH 0.732 0.218 2 0.089
MOSMOS 0.732 0.113 1 0.801
LATS1LATS1 0.731 0.289 -3 0.404
DYRK4DYRK4 0.730 0.206 1 0.571
WNK3WNK3 0.727 0.073 1 0.778
ERK5ERK5 0.727 0.042 1 0.783
TBK1TBK1 0.726 0.016 1 0.762
TGFBR2TGFBR2 0.726 0.071 -2 0.772
COTCOT 0.725 -0.071 2 0.128
ATRATR 0.725 0.076 1 0.763
MTORMTOR 0.725 0.023 1 0.754
IKKBIKKB 0.725 0.059 -2 0.743
PRPKPRPK 0.724 -0.045 -1 0.841
CHAK2CHAK2 0.724 0.134 -1 0.865
RIPK1RIPK1 0.724 0.122 1 0.740
PKCIPKCI 0.724 0.215 2 0.117
CDK7CDK7 0.723 0.092 1 0.610
RIPK3RIPK3 0.723 0.025 3 0.784
PKCZPKCZ 0.722 0.162 2 0.133
IKKEIKKE 0.722 0.013 1 0.773
PDHK4PDHK4 0.722 -0.092 1 0.813
PDHK1PDHK1 0.722 -0.032 1 0.824
HUNKHUNK 0.721 -0.026 2 0.110
BCKDKBCKDK 0.720 -0.011 -1 0.819
GCN2GCN2 0.720 -0.121 2 0.140
CAMK2GCAMK2G 0.718 -0.064 2 0.151
KISKIS 0.718 0.049 1 0.636
ULK2ULK2 0.717 -0.136 2 0.127
MASTLMASTL 0.716 -0.003 -2 0.810
BMPR2BMPR2 0.716 -0.092 -2 0.861
CDK10CDK10 0.715 0.143 1 0.557
BUB1BUB1 0.714 0.233 -5 0.877
IRE1IRE1 0.713 0.001 1 0.716
TTBK2TTBK2 0.713 -0.077 2 0.093
WNK4WNK4 0.712 0.145 -2 0.862
CHAK1CHAK1 0.711 0.073 2 0.225
CDK14CDK14 0.711 0.106 1 0.575
PASKPASK 0.711 0.293 -3 0.449
ATMATM 0.711 0.033 1 0.714
NEK2NEK2 0.711 -0.024 2 0.168
FAM20CFAM20C 0.710 -0.052 2 0.082
NEK7NEK7 0.709 -0.126 -3 0.140
DSTYKDSTYK 0.708 -0.149 2 0.144
ANKRD3ANKRD3 0.708 -0.005 1 0.798
IRE2IRE2 0.708 -0.019 2 0.106
MLK2MLK2 0.708 -0.074 2 0.158
GRK1GRK1 0.708 -0.019 -2 0.859
DLKDLK 0.708 0.039 1 0.766
NEK6NEK6 0.707 -0.092 -2 0.796
DNAPKDNAPK 0.707 0.039 1 0.723
ULK1ULK1 0.707 -0.178 -3 0.117
NEK9NEK9 0.707 -0.113 2 0.146
MLK1MLK1 0.706 -0.126 2 0.115
CK1ECK1E 0.706 -0.059 -3 0.088
GRK5GRK5 0.706 -0.109 -3 0.162
SMG1SMG1 0.704 0.015 1 0.724
CDK8CDK8 0.704 -0.018 1 0.604
PKRPKR 0.704 0.028 1 0.768
IKKAIKKA 0.704 -0.050 -2 0.722
CDK18CDK18 0.704 0.029 1 0.534
GRK6GRK6 0.703 -0.052 1 0.762
CDK19CDK19 0.703 -0.005 1 0.569
CK1DCK1D 0.703 -0.042 -3 0.068
MEK1MEK1 0.703 -0.014 2 0.170
CK1A2CK1A2 0.702 -0.049 -3 0.094
IRAK4IRAK4 0.702 0.025 1 0.737
PLK4PLK4 0.702 -0.062 2 0.075
ALK4ALK4 0.701 -0.010 -2 0.818
PDK1PDK1 0.700 0.258 1 0.749
P38AP38A 0.700 0.016 1 0.657
ERK7ERK7 0.699 -0.029 2 0.078
MLK3MLK3 0.699 -0.091 2 0.112
BMPR1BBMPR1B 0.699 0.003 1 0.721
TTBK1TTBK1 0.698 -0.074 2 0.073
CK1G1CK1G1 0.698 -0.073 -3 0.080
GRK4GRK4 0.698 -0.127 -2 0.837
MST3MST3 0.698 0.063 2 0.166
DRAK1DRAK1 0.698 0.037 1 0.658
TGFBR1TGFBR1 0.698 -0.033 -2 0.793
CDK9CDK9 0.697 0.015 1 0.596
VRK2VRK2 0.697 -0.086 1 0.799
JNK2JNK2 0.697 0.009 1 0.567
MPSK1MPSK1 0.697 0.040 1 0.686
LOKLOK 0.696 0.147 -2 0.786
YSK4YSK4 0.696 -0.067 1 0.763
PERKPERK 0.695 -0.060 -2 0.809
LKB1LKB1 0.695 0.089 -3 0.157
PBKPBK 0.694 0.128 1 0.692
CDK12CDK12 0.694 0.019 1 0.565
CDK13CDK13 0.694 -0.008 1 0.587
ERK2ERK2 0.693 -0.016 1 0.617
P38BP38B 0.693 0.005 1 0.600
MEK5MEK5 0.693 -0.015 2 0.149
ERK1ERK1 0.693 -0.005 1 0.588
CDK17CDK17 0.692 0.003 1 0.483
BRAFBRAF 0.692 -0.003 -4 0.789
PRP4PRP4 0.692 -0.053 -3 0.119
GRK7GRK7 0.692 0.022 1 0.689
ALK2ALK2 0.691 -0.031 -2 0.807
IRAK1IRAK1 0.691 -0.043 -1 0.779
HPK1HPK1 0.691 0.161 1 0.785
HRIHRI 0.690 -0.076 -2 0.806
PLK1PLK1 0.690 -0.106 -2 0.750
TLK1TLK1 0.689 -0.041 -2 0.795
PINK1PINK1 0.689 -0.046 1 0.724
MEKK6MEKK6 0.689 0.041 1 0.780
YANK3YANK3 0.689 0.000 2 0.050
CDK5CDK5 0.689 -0.022 1 0.617
MLK4MLK4 0.689 -0.139 2 0.085
TAO3TAO3 0.689 0.067 1 0.753
MEKK1MEKK1 0.688 -0.096 1 0.769
JNK3JNK3 0.688 -0.024 1 0.599
TLK2TLK2 0.688 -0.066 1 0.755
NEK11NEK11 0.688 -0.010 1 0.760
NEK5NEK5 0.687 -0.072 1 0.771
ACVR2BACVR2B 0.687 -0.040 -2 0.762
KHS2KHS2 0.687 0.160 1 0.799
PLK3PLK3 0.686 -0.128 2 0.115
ZAKZAK 0.686 -0.097 1 0.745
KHS1KHS1 0.686 0.148 1 0.799
NEK4NEK4 0.686 0.020 1 0.771
ACVR2AACVR2A 0.686 -0.060 -2 0.751
TAO2TAO2 0.685 0.035 2 0.169
SLKSLK 0.685 0.081 -2 0.735
MEKK2MEKK2 0.685 -0.087 2 0.125
GCKGCK 0.685 0.107 1 0.783
CDK16CDK16 0.684 -0.000 1 0.499
CDK4CDK4 0.684 0.052 1 0.550
CAMKK2CAMKK2 0.684 0.006 -2 0.759
GRK2GRK2 0.684 -0.061 -2 0.732
NEK8NEK8 0.684 0.006 2 0.136
P38GP38G 0.684 -0.012 1 0.488
MAP3K15MAP3K15 0.684 0.008 1 0.740
BMPR1ABMPR1A 0.683 -0.017 1 0.704
MEKK3MEKK3 0.682 -0.118 1 0.758
LRRK2LRRK2 0.682 0.099 2 0.161
RIPK2RIPK2 0.681 -0.005 1 0.711
STK33STK33 0.681 -0.040 2 0.090
CDK1CDK1 0.681 -0.016 1 0.557
HGKHGK 0.681 0.043 3 0.820
TNIKTNIK 0.680 0.066 3 0.817
MINKMINK 0.680 0.061 1 0.792
NEK1NEK1 0.679 0.004 1 0.753
TAK1TAK1 0.679 0.039 1 0.791
GAKGAK 0.679 -0.003 1 0.743
NEK3NEK3 0.678 -0.011 1 0.744
CAMKK1CAMKK1 0.676 -0.103 -2 0.753
YSK1YSK1 0.675 0.007 2 0.151
HASPINHASPIN 0.675 0.073 -1 0.713
P38DP38D 0.675 -0.013 1 0.519
CDK2CDK2 0.675 -0.066 1 0.625
GSK3BGSK3B 0.674 -0.006 4 0.409
MST2MST2 0.673 -0.072 1 0.791
GRK3GRK3 0.673 -0.066 -2 0.698
MST1MST1 0.672 -0.019 1 0.779
CK1ACK1A 0.672 -0.061 -3 0.044
MEK2MEK2 0.671 -0.084 2 0.162
CDK6CDK6 0.670 -0.010 1 0.561
VRK1VRK1 0.668 -0.069 2 0.121
CDK3CDK3 0.668 -0.019 1 0.503
EEF2KEEF2K 0.667 -0.083 3 0.778
TAO1TAO1 0.666 0.048 1 0.717
PLK2PLK2 0.664 -0.111 -3 0.096
GSK3AGSK3A 0.664 -0.021 4 0.415
JNK1JNK1 0.662 -0.036 1 0.543
MYO3BMYO3B 0.662 0.019 2 0.190
TTKTTK 0.661 -0.005 -2 0.782
BIKEBIKE 0.660 0.001 1 0.624
LIMK2_TYRLIMK2_TYR 0.659 0.198 -3 0.239
PDHK3_TYRPDHK3_TYR 0.656 0.061 4 0.884
CK2A2CK2A2 0.656 -0.060 1 0.637
ASK1ASK1 0.655 -0.059 1 0.726
TESK1_TYRTESK1_TYR 0.654 0.099 3 0.877
TNK2TNK2 0.653 0.122 3 0.808
MYO3AMYO3A 0.653 -0.005 1 0.756
PKMYT1_TYRPKMYT1_TYR 0.651 0.070 3 0.867
CK1G3CK1G3 0.651 -0.075 -3 0.041
OSR1OSR1 0.650 -0.083 2 0.158
RETRET 0.649 0.061 1 0.770
MAP2K4_TYRMAP2K4_TYR 0.649 0.111 -1 0.850
MAP2K7_TYRMAP2K7_TYR 0.647 -0.032 2 0.171
TNK1TNK1 0.647 0.098 3 0.810
NEK10_TYRNEK10_TYR 0.646 0.146 1 0.679
AAK1AAK1 0.646 0.015 1 0.529
EPHA6EPHA6 0.645 -0.021 -1 0.831
MST1RMST1R 0.645 0.036 3 0.846
ROS1ROS1 0.645 0.032 3 0.804
CK2A1CK2A1 0.645 -0.072 1 0.615
PINK1_TYRPINK1_TYR 0.644 0.071 1 0.759
LIMK1_TYRLIMK1_TYR 0.644 0.028 2 0.178
YANK2YANK2 0.643 -0.059 2 0.048
DDR1DDR1 0.643 0.032 4 0.809
EPHB4EPHB4 0.642 -0.024 -1 0.828
TYK2TYK2 0.642 0.002 1 0.782
TYRO3TYRO3 0.642 -0.042 3 0.819
ALPHAK3ALPHAK3 0.642 -0.058 -1 0.733
PDHK4_TYRPDHK4_TYR 0.641 -0.059 2 0.196
STLK3STLK3 0.641 -0.108 1 0.719
JAK1JAK1 0.641 0.085 1 0.750
MAP2K6_TYRMAP2K6_TYR 0.640 -0.050 -1 0.851
TNNI3K_TYRTNNI3K_TYR 0.640 0.014 1 0.777
AXLAXL 0.639 0.010 3 0.825
JAK2JAK2 0.639 -0.025 1 0.784
ABL2ABL2 0.639 0.013 -1 0.812
PDHK1_TYRPDHK1_TYR 0.638 -0.068 -1 0.856
BMPR2_TYRBMPR2_TYR 0.637 -0.060 -1 0.830
PDGFRBPDGFRB 0.636 -0.015 3 0.838
ABL1ABL1 0.636 -0.009 -1 0.809
DDR2DDR2 0.636 0.089 3 0.783
TEKTEK 0.634 -0.053 3 0.771
PDGFRAPDGFRA 0.634 -0.014 3 0.832
CSF1RCSF1R 0.634 -0.063 3 0.830
LTKLTK 0.633 0.012 3 0.800
EPHB3EPHB3 0.633 -0.056 -1 0.820
ALKALK 0.633 0.023 3 0.774
EPHA4EPHA4 0.633 -0.079 2 0.134
EPHA1EPHA1 0.633 -0.008 3 0.815
JAK3JAK3 0.633 -0.038 1 0.743
EPHB1EPHB1 0.633 -0.061 1 0.798
INSRRINSRR 0.632 -0.028 3 0.786
MERTKMERTK 0.632 -0.048 3 0.825
FGFR2FGFR2 0.632 -0.066 3 0.835
TXKTXK 0.631 -0.040 1 0.755
FGFR1FGFR1 0.631 -0.060 3 0.817
LCKLCK 0.630 0.001 -1 0.815
FLT3FLT3 0.630 -0.035 3 0.816
FERFER 0.630 -0.088 1 0.804
EPHB2EPHB2 0.629 -0.074 -1 0.807
KDRKDR 0.629 -0.032 3 0.804
SRMSSRMS 0.629 -0.091 1 0.788
FGRFGR 0.629 -0.074 1 0.771
EPHA7EPHA7 0.629 -0.056 2 0.126
ITKITK 0.628 -0.069 -1 0.809
YES1YES1 0.627 -0.079 -1 0.840
HCKHCK 0.626 -0.068 -1 0.819
BLKBLK 0.626 -0.008 -1 0.813
EPHA3EPHA3 0.625 -0.084 2 0.121
BTKBTK 0.625 -0.088 -1 0.806
PTK2BPTK2B 0.624 -0.039 -1 0.795
TECTEC 0.623 -0.052 -1 0.767
PTK6PTK6 0.622 -0.053 -1 0.747
KITKIT 0.622 -0.093 3 0.831
BMXBMX 0.621 -0.048 -1 0.733
METMET 0.621 -0.058 3 0.828
NTRK1NTRK1 0.619 -0.106 -1 0.811
EPHA5EPHA5 0.618 -0.083 2 0.115
WEE1_TYRWEE1_TYR 0.618 -0.061 -1 0.765
FRKFRK 0.618 -0.083 -1 0.836
NTRK2NTRK2 0.618 -0.093 3 0.797
FGFR3FGFR3 0.617 -0.103 3 0.808
INSRINSR 0.617 -0.081 3 0.759
CK1G2CK1G2 0.616 -0.079 -3 0.057
ERBB2ERBB2 0.616 -0.104 1 0.715
FLT4FLT4 0.616 -0.099 3 0.793
EPHA8EPHA8 0.614 -0.079 -1 0.784
NTRK3NTRK3 0.612 -0.087 -1 0.764
MATKMATK 0.611 -0.081 -1 0.734
LYNLYN 0.611 -0.091 3 0.760
FLT1FLT1 0.610 -0.121 -1 0.788
FYNFYN 0.610 -0.086 -1 0.780
CSKCSK 0.608 -0.101 2 0.126
PTK2PTK2 0.605 -0.071 -1 0.730
MUSKMUSK 0.603 -0.080 1 0.612
EPHA2EPHA2 0.603 -0.101 -1 0.747
EGFREGFR 0.601 -0.111 1 0.621
SRCSRC 0.601 -0.108 -1 0.783
FGFR4FGFR4 0.601 -0.108 -1 0.741
IGF1RIGF1R 0.598 -0.101 3 0.707
SYKSYK 0.593 -0.095 -1 0.715
ERBB4ERBB4 0.592 -0.092 1 0.633
FESFES 0.591 -0.102 -1 0.708
ZAP70ZAP70 0.576 -0.067 -1 0.652