Motif 340 (n=271)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A1L390 | PLEKHG3 | S759 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
A1L390 | PLEKHG3 | S1081 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
A6ND36 | FAM83G | S650 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
A7KAX9 | ARHGAP32 | S1585 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
A7KAX9 | ARHGAP32 | S1796 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
E7EW31 | PROB1 | S306 | ochoa | Proline-rich basic protein 1 | None |
O00116 | AGPS | S589 | ochoa | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
O14497 | ARID1A | S638 | ochoa|psp | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
O14545 | TRAFD1 | S409 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
O14639 | ABLIM1 | S706 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
O14908 | GIPC1 | S232 | ochoa | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | May be involved in G protein-linked signaling. |
O15018 | PDZD2 | S543 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
O15018 | PDZD2 | S944 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
O15151 | MDM4 | S367 | ochoa|psp | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
O43182 | ARHGAP6 | S213 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
O43255 | SIAH2 | S167 | psp | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11483518, PubMed:19224863, PubMed:9334332). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11483518, PubMed:19224863, PubMed:22878263, PubMed:9334332). Has some overlapping function with SIAH1 (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1. {ECO:0000250|UniProtKB:Q06986, ECO:0000269|PubMed:11483518, ECO:0000269|PubMed:12411493, ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:28546513, ECO:0000269|PubMed:9334332}. |
O43815 | STRN | S672 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
O60292 | SIPA1L3 | S97 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
O60296 | TRAK2 | S420 | ochoa | Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) | May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}. |
O60296 | TRAK2 | S889 | ochoa | Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) | May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}. |
O60664 | PLIN3 | S31 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
O75140 | DEPDC5 | S570 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
O75157 | TSC22D2 | S598 | ochoa | TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4) | Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth. {ECO:0000269|PubMed:27573352}. |
O75179 | ANKRD17 | S2489 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
O75376 | NCOR1 | Y89 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
O75791 | GRAP2 | T262 | ochoa|psp | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
O75925 | PIAS1 | S510 | ochoa|psp | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
O94761 | RECQL4 | S101 | ochoa | ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4) | An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction (PubMed:28653661). Does not unwind more than 18 bp of dsDNA (PubMed:28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed:22730300). The core helicase domain binds ssDNA (PubMed:22730300, PubMed:28653661). {ECO:0000269|PubMed:15317757, ECO:0000269|PubMed:22730300, ECO:0000269|PubMed:28653661}. |
O94885 | SASH1 | S923 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
O94972 | TRIM37 | S454 | ochoa | E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) | E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}. |
O95049 | TJP3 | S346 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
O95208 | EPN2 | S173 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
P00973 | OAS1 | S50 | ochoa | 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34145065, PubMed:34581622). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:12799444, ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:23319625, ECO:0000269|PubMed:34145065, ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p46]: When prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target (PubMed:34581622). The same mechanism is necessary to initiate a block to cardiovirus EMCV (PubMed:34581622). {ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p42]: Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}. |
P04049 | RAF1 | S259 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
P04049 | RAF1 | S621 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
P05177 | CYP1A2 | S82 | ochoa | Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14725854, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21068195, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:9435160, ECO:0000305|PubMed:16522833}. |
P05549 | TFAP2A | S239 | ochoa|psp | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
P06576 | ATP5F1B | S465 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
P08559 | PDHA1 | S314 | psp | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}. |
P10276 | RARA | S369 | psp | Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) | Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:21152046, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}. |
P10398 | ARAF | S582 | ochoa|psp | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
P11836 | MS4A1 | S36 | ochoa | B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739). {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:18474602, ECO:0000269|PubMed:3925015, ECO:0000269|PubMed:7684739}. |
P13631 | RARG | S371 | psp | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}. |
P15056 | BRAF | S729 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
P16144 | ITGB4 | S1325 | psp | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
P17752 | TPH1 | S260 | psp | Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) | Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. {ECO:0000250|UniProtKB:P17532}. |
P18887 | XRCC1 | S151 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
P21730 | C5AR1 | S314 | psp | C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
P23229 | ITGA6 | S638 | ochoa | Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] | Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000250|UniProtKB:Q61739, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
P26045 | PTPN3 | S835 | psp | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
P26358 | DNMT1 | S878 | ochoa|psp | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
P26373 | RPL13 | S52 | ochoa | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}. |
P26641 | EEF1G | S33 | ochoa | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
P28290 | ITPRID2 | S739 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
P30304 | CDC25A | S107 | psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
P30304 | CDC25A | S178 | ochoa|psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
P30305 | CDC25B | S151 | ochoa|psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
P30305 | CDC25B | S230 | ochoa|psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
P32927 | CSF2RB | S601 | ochoa|psp | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
P35670 | ATP7B | S1121 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
P39880 | CUX1 | S425 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
P41252 | IARS1 | S346 | ochoa | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
P47736 | RAP1GAP | S490 | psp | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
P48147 | PREP | S667 | ochoa | Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) | Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. |
P49792 | RANBP2 | S1509 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P50549 | ETV1 | S191 | ochoa|psp | ETS translocation variant 1 (Ets-related protein 81) | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}. |
P50549 | ETV1 | S216 | ochoa|psp | ETS translocation variant 1 (Ets-related protein 81) | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}. |
P52597 | HNRNPF | S195 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
P52943 | CRIP2 | S104 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
P53804 | TTC3 | S378 | ochoa|psp | E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) | E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). {ECO:0000269|PubMed:17488780, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:24695496, ECO:0000269|PubMed:30203323, ECO:0000269|PubMed:30696809}. |
P58340 | MLF1 | S34 | ochoa | Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}. |
P83369 | LSM11 | S280 | ochoa | U7 snRNA-associated Sm-like protein LSm11 | Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750). {ECO:0000250|UniProtKB:Q8BUV6, ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:16914750, ECO:0000269|PubMed:33230297}. |
Q00610 | CLTC | S403 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
Q03164 | KMT2A | S3027 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q04206 | RELA | S281 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
Q08495 | DMTN | S269 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
Q08495 | DMTN | S333 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
Q09019 | DMWD | S495 | ochoa | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}. |
Q12774 | ARHGEF5 | S606 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
Q12802 | AKAP13 | S1226 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
Q12968 | NFATC3 | S416 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
Q13009 | TIAM1 | S60 | ochoa|psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
Q13418 | ILK | S246 | psp | Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) | Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447). {ECO:0000250|UniProtKB:O55222, ECO:0000250|UniProtKB:Q99J82, ECO:0000269|PubMed:16517730, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:18283114, ECO:0000269|PubMed:20005845, ECO:0000269|PubMed:30367047, ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:9736715}. |
Q13425 | SNTB2 | S258 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
Q13625 | TP53BP2 | S361 | ochoa|psp | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
Q13698 | CACNA1S | S1617 | ochoa | Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1) | Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. {ECO:0000269|PubMed:28012042}. |
Q13873 | BMPR2 | S757 | ochoa|psp | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
Q14005 | IL16 | S966 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
Q14151 | SAFB2 | S787 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
Q14432 | PDE3A | S312 | ochoa|psp | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
Q14451 | GRB7 | S63 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
Q14678 | KANK1 | S70 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
Q15390 | MTFR1 | S119 | ochoa | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}. |
Q15418 | RPS6KA1 | S307 | ochoa | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
Q15697 | ZNF174 | S265 | ochoa | Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) | Transcriptional repressor. {ECO:0000269|PubMed:7673192}. |
Q15785 | TOMM34 | S160 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
Q15884 | ENTREP1 | S275 | ochoa | Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin) | Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway. {ECO:0000269|PubMed:34927784}. |
Q2KHR2 | RFX7 | S1225 | ochoa | DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) | Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250|UniProtKB:A0A1L8H0H2, ECO:0000269|PubMed:29967452, ECO:0000269|PubMed:34197623}. |
Q2LD37 | BLTP1 | S703 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
Q2M1Z3 | ARHGAP31 | S272 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
Q3KP66 | INAVA | S616 | ochoa | Innate immunity activator protein | Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}. |
Q4AC94 | C2CD3 | S2328 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
Q4G0A6 | MINDY4 | S352 | ochoa | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4) | Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000250|UniProtKB:Q8NBR6}. |
Q4VX76 | SYTL3 | S243 | ochoa | Synaptotagmin-like protein 3 (Exophilin-6) | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). {ECO:0000250}. |
Q52LW3 | ARHGAP29 | S1019 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
Q5JXC2 | MIIP | S113 | ochoa | Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45) | Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269|PubMed:14617774}. |
Q5PRF9 | SAMD4B | S642 | psp | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
Q5T0W9 | FAM83B | S914 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
Q5T0Z8 | C6orf132 | S314 | ochoa | Uncharacterized protein C6orf132 | None |
Q5T0Z8 | C6orf132 | S1087 | ochoa | Uncharacterized protein C6orf132 | None |
Q5T447 | HECTD3 | S192 | psp | E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) | E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}. |
Q5T5C0 | STXBP5 | S759 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
Q5TC79 | ZBTB37 | S188 | ochoa | Zinc finger and BTB domain-containing protein 37 | May be involved in transcriptional regulation. |
Q5VSL9 | STRIP1 | S788 | ochoa | Striatin-interacting protein 1 (Protein FAM40A) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}. |
Q5VUJ6 | LRCH2 | S327 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 2 | May play a role in the organization of the cytoskeleton. {ECO:0000250|UniProtKB:Q960C5, ECO:0000250|UniProtKB:Q96II8}. |
Q5VV41 | ARHGEF16 | S578 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
Q5VZL5 | ZMYM4 | S882 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
Q6AI14 | SLC9A4 | S660 | ochoa | Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) | Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity). {ECO:0000250|UniProtKB:P26434, ECO:0000250|UniProtKB:Q8BUE1}. |
Q6FI81 | CIAPIN1 | S287 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
Q6N021 | TET2 | S99 | ochoa|psp | Methylcytosine dioxygenase TET2 (EC 1.14.11.80) | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}. |
Q6NSI3 | FAM53A | S125 | ochoa | Protein FAM53A (Dorsal neural-tube nuclear protein) | May play an important role in neural development; the dorsomedial roof of the third ventricle. {ECO:0000250|UniProtKB:Q5ZKN5}. |
Q6P2E9 | EDC4 | S405 | psp | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
Q6P3S6 | FBXO42 | S488 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
Q6P5Z2 | PKN3 | S488 | ochoa | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) | Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
Q6PIJ6 | FBXO38 | S850 | ochoa | F-box only protein 38 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}. |
Q6UB99 | ANKRD11 | S1814 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
Q6VUC0 | TFAP2E | S246 | ochoa | Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
Q6VY07 | PACS1 | S519 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
Q6Y7W6 | GIGYF2 | S684 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
Q6ZV29 | PNPLA7 | S355 | ochoa | Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5) | Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). {ECO:0000250|UniProtKB:A2AJ88}. |
Q711Q0 | CEFIP | S160 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
Q7Z309 | PABIR2 | S25 | ochoa | PABIR family member 2 | None |
Q7Z333 | SETX | T2474 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
Q7Z3C6 | ATG9A | S761 | ochoa|psp | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
Q7Z401 | DENND4A | S755 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
Q7Z5H3 | ARHGAP22 | S395 | ochoa|psp | Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
Q7Z698 | SPRED2 | S206 | ochoa | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) | Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}. |
Q86TB3 | ALPK2 | S1078 | ochoa | Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) | Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000269|PubMed:29888752, ECO:0000303|PubMed:10021370}. |
Q86UR1 | NOXA1 | S172 | psp | NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox) | Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:14978110, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17602954, ECO:0000269|PubMed:19755710}. |
Q86V87 | FHIP2B | S325 | psp | FHF complex subunit HOOK-interacting protein 2B (FHIP2B) (Retinoic acid-induced protein 16) | Able to activate MAPK/ERK and TGFB signaling pathways (PubMed:22971576). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (By similarity). May play a role in cell proliferation (PubMed:22971576). {ECO:0000250|UniProtKB:Q80YR2, ECO:0000269|PubMed:22971576}. |
Q86VQ1 | GLCCI1 | S172 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
Q86W92 | PPFIBP1 | S540 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
Q86WR7 | PROSER2 | S400 | ochoa | Proline and serine-rich protein 2 | None |
Q86X10 | RALGAPB | S359 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Q86YV0 | RASAL3 | S72 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
Q86YV0 | RASAL3 | S819 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
Q8IUW3 | SPATA2L | S317 | ochoa | Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) | None |
Q8IVE3 | PLEKHH2 | S459 | ochoa | Pleckstrin homology domain-containing family H member 2 | In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. |
Q8IY18 | SMC5 | S35 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
Q8IYK8 | REM2 | S68 | ochoa | GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) | Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}. |
Q8IYT8 | ULK2 | S528 | ochoa | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}. |
Q8IZU2 | WDR17 | S1198 | ochoa | WD repeat-containing protein 17 | None |
Q8N103 | TAGAP | S377 | ochoa | T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) | May function as a GTPase-activating protein and may play important roles during T-cell activation. {ECO:0000269|PubMed:15177553}. |
Q8N1W1 | ARHGEF28 | S535 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
Q8N1W1 | ARHGEF28 | S1538 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
Q8N4X5 | AFAP1L2 | S484 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
Q8N5H7 | SH2D3C | S447 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
Q8N5S9 | CAMKK1 | S475 | ochoa|psp | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
Q8N8S7 | ENAH | S537 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
Q8NCE2 | MTMR14 | S415 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
Q8NFD5 | ARID1B | S747 | psp | AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Q8TBA6 | GOLGA5 | S116 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
Q8TBC3 | SHKBP1 | T163 | ochoa | SH3KBP1-binding protein 1 (SETA-binding protein 1) | Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}. |
Q8TBZ3 | WDR20 | S434 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
Q8TDM6 | DLG5 | S1115 | ochoa|psp | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
Q8TEW0 | PARD3 | S144 | ochoa|psp | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
Q8TEW8 | PARD3B | S141 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
Q8TF42 | UBASH3B | S377 | ochoa | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}. |
Q8TF72 | SHROOM3 | S1242 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
Q8WUA7 | TBC1D22A | S167 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
Q8WXD9 | CASKIN1 | S1067 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
Q8WYL5 | SSH1 | S515 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
Q8WZ82 | OVCA2 | S168 | ochoa | Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase domain-containing protein) (Ovarian cancer-associated gene 2 protein) | Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons. {ECO:0000269|PubMed:32182256}. |
Q92481 | TFAP2B | S258 | ochoa | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
Q92622 | RUBCN | S248 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
Q92754 | TFAP2C | S252 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
Q92794 | KAT6A | S1861 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
Q92932 | PTPRN2 | S375 | ochoa | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] | Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}. |
Q92974 | ARHGEF2 | S886 | ochoa|psp | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
Q96A59 | MARVELD3 | S156 | ochoa | MARVEL domain-containing protein 3 | As a component of tight junctions, plays a role in paracellular ion conductivity. {ECO:0000269|PubMed:20028514}. |
Q96A65 | EXOC4 | S410 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
Q96AD5 | PNPLA2 | S404 | ochoa | Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2) | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). {ECO:0000250|UniProtKB:Q8BJ56, ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:17032652, ECO:0000269|PubMed:17603008, ECO:0000269|PubMed:28578400, ECO:0000269|PubMed:34903883, ECO:0000269|PubMed:35676490}. |
Q96B18 | DACT3 | S188 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
Q96EP0 | RNF31 | S466 | ochoa | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. |
Q96JQ2 | CLMN | S419 | ochoa | Calmin (Calponin-like transmembrane domain protein) | None |
Q96K78 | ADGRG7 | S746 | ochoa | Adhesion G-protein coupled receptor G7 (G-protein coupled receptor 128) | Orphan receptor. |
Q96MU7 | YTHDC1 | S515 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
Q96N96 | SPATA13 | T617 | psp | Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}. |
Q96NW4 | ANKRD27 | S962 | ochoa | Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) | May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:23104059, ECO:0000269|PubMed:24856514, ECO:0000305|PubMed:16525121, ECO:0000305|PubMed:18477474, ECO:0000305|PubMed:22705394}. |
Q96P16 | RPRD1A | S285 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
Q96PE2 | ARHGEF17 | S735 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
Q96PY6 | NEK1 | S1052 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
Q96Q42 | ALS2 | S483 | ochoa|psp | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
Q96S53 | TESK2 | S346 | ochoa | Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. |
Q96S53 | TESK2 | S456 | ochoa | Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. |
Q96TC7 | RMDN3 | S46 | ochoa|psp | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
Q99570 | PIK3R4 | S755 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
Q99698 | LYST | S2105 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
Q99973 | TEP1 | S2353 | ochoa | Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) | Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). {ECO:0000250|UniProtKB:P97499, ECO:0000269|PubMed:19179534}. |
Q99983 | OMD | S226 | ochoa | Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) | May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. {ECO:0000250|UniProtKB:O77742}. |
Q9BQ48 | MRPL34 | S71 | ochoa | Large ribosomal subunit protein bL34m (39S ribosomal protein L34, mitochondrial) (L34mt) (MRP-L34) | None |
Q9BU19 | ZNF692 | S470 | psp | Zinc finger protein 692 (AICAR responsive element binding protein) | May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}. |
Q9BWT7 | CARD10 | S638 | ochoa | Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}. |
Q9BZF2 | OSBPL7 | S226 | ochoa | Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7) | None |
Q9BZF3 | OSBPL6 | S290 | ochoa | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. |
Q9C073 | FAM117A | S67 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
Q9C073 | FAM117A | S91 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
Q9C0I1 | MTMR12 | S564 | ochoa | Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) | Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:11504939, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:23818870}. |
Q9C0K0 | BCL11B | S110 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
Q9GZY8 | MFF | S179 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
Q9H019 | MTFR1L | S103 | ochoa | Mitochondrial fission regulator 1-like | Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}. |
Q9H1H9 | KIF13A | S1384 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
Q9H1K1 | ISCU | S29 | ochoa | Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) | [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable) (PubMed:24971490, PubMed:29576242, PubMed:30031876, PubMed:34824239). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}. |
Q9H4A3 | WNK1 | S167 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
Q9H4A3 | WNK1 | S2286 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
Q9H4L5 | OSBPL3 | S251 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
Q9H6Z4 | RANBP3 | S333 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
Q9HA47 | UCK1 | S253 | ochoa | Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}. |
Q9HB20 | PLEKHA3 | S211 | ochoa | Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) | Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}. |
Q9HC77 | CPAP | S1109 | ochoa|psp | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
Q9NP56 | PDE7B | S45 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 7B (EC 3.1.4.53) (cAMP-specific phosphodiesterase 7B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:10814504, PubMed:10872825). May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (PubMed:10814504). {ECO:0000269|PubMed:10814504, ECO:0000269|PubMed:10872825}. |
Q9NQT8 | KIF13B | S1381 | ochoa|psp | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
Q9NRA0 | SPHK2 | Y378 | psp | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
Q9NRL3 | STRN4 | S635 | ochoa | Striatin-4 (Zinedin) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}. |
Q9NVI7 | ATAD3A | S357 | ochoa | ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:17210950, PubMed:20154147, PubMed:22453275, PubMed:31522117, PubMed:37832546, PubMed:39116259). May play an important role in mitochondrial protein synthesis (PubMed:22453275). May also participate in mitochondrial DNA replication (PubMed:17210950). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (PubMed:17210950). Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (PubMed:22453275). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress (PubMed:39116259). Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity (PubMed:39116259). Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR) (PubMed:37832546). {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:39116259}. |
Q9NYF3 | FAM53C | S122 | ochoa | Protein FAM53C | None |
Q9NYL2 | MAP3K20 | S593 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
Q9NZQ3 | NCKIPSD | S147 | ochoa | NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) | Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. |
Q9NZV7 | ZIM2 | S26 | ochoa | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
Q9P203 | BTBD7 | S794 | ochoa | BTB/POZ domain-containing protein 7 | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}. |
Q9P243 | ZFAT | S53 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
Q9P246 | STIM2 | S719 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
Q9P266 | JCAD | S1044 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
Q9UBD5 | ORC3 | S23 | ochoa | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:31160578}. |
Q9UBP0 | SPAST | S245 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
Q9UBS0 | RPS6KB2 | S416 | ochoa | Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) | Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
Q9UBY9 | HSPB7 | S60 | ochoa | Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) | None |
Q9UJ83 | HACL1 | S192 | ochoa | 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) | Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:10468558, PubMed:21708296, PubMed:28289220). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:10468558, PubMed:21708296, PubMed:28289220). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}. |
Q9UKE5 | TNIK | S640 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
Q9UKE5 | TNIK | S701 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
Q9UKF7 | PITPNC1 | S299 | ochoa|psp | Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) | [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}. |
Q9UKN1 | MUC12 | S1616 | ochoa | Mucin-12 (MUC-12) (Mucin-11) (MUC-11) | Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}. |
Q9UKV8 | AGO2 | S798 | psp | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}. |
Q9ULR3 | PPM1H | S124 | ochoa | Protein phosphatase 1H (EC 3.1.3.16) | Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269|PubMed:22586611}. |
Q9ULV3 | CIZ1 | S868 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
Q9UNH5 | CDC14A | S429 | psp | Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}. |
Q9UNI6 | DUSP12 | S241 | ochoa | Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}. |
Q9UPA5 | BSN | S2851 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
Q9UPN9 | TRIM33 | S622 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
Q9UPQ0 | LIMCH1 | S493 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9UPU9 | SAMD4A | S665 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
Q9UPV9 | TRAK1 | S919 | ochoa | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}. |
Q9UPY3 | DICER1 | S643 | ochoa | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
Q9Y2G4 | ANKRD6 | S289 | ochoa | Ankyrin repeat domain-containing protein 6 (Diversin) | Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000250}. |
Q9Y2I9 | TBC1D30 | S744 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
Q9Y2R2 | PTPN22 | S449 | ochoa | Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}. |
Q9Y2U8 | LEMD3 | S291 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
Q9Y2U8 | LEMD3 | S777 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
Q9Y4A5 | TRRAP | S2077 | ochoa | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}. |
Q9Y580 | RBM7 | S136 | ochoa|psp | RNA-binding protein 7 (RNA-binding motif protein 7) | RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104, PubMed:27871484). NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:25189701, PubMed:25852104, PubMed:27871484). Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104). Participates in several biological processes including DNA damage response (DDR) and stress response (PubMed:25525152, PubMed:30824372). During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome (PubMed:25525152). Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability (PubMed:30824372). {ECO:0000269|PubMed:25189701, ECO:0000269|PubMed:25525152, ECO:0000269|PubMed:25578728, ECO:0000269|PubMed:25852104, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:30824372}. |
Q9Y678 | COPG1 | S593 | ochoa | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |
Q9Y6Q9 | NCOA3 | S967 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
P27824 | CANX | S362 | Sugiyama | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
Q9UQ80 | PA2G4 | S335 | Sugiyama | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
Q12809 | KCNH2 | S1137 | ELM|EPSD | Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1) | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Channel properties are modulated by cAMP and subunit assembly (PubMed:10837251). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (PubMed:10219239, PubMed:9230439). {ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:10753933, ECO:0000269|PubMed:10790218, ECO:0000269|PubMed:10837251, ECO:0000269|PubMed:11997281, ECO:0000269|PubMed:12063277, ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:22314138, ECO:0000269|PubMed:22359612, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:9230439, ECO:0000269|PubMed:9351446, ECO:0000269|PubMed:9765245}.; FUNCTION: [Isoform A-USO]: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:9765245}.; FUNCTION: [Isoform B-USO]: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421}. |
Q16613 | AANAT | T31 | ELM|iPTMNet|EPSD | Serotonin N-acetyltransferase (Serotonin acetylase) (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT) | Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. {ECO:0000269|PubMed:11313340, ECO:0000305}. |
Q8TD08 | MAPK15 | S415 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
P52952 | NKX2-5 | S164 | SIGNOR|iPTMNet | Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E) | Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (PubMed:29899023). {ECO:0000250|UniProtKB:P42582, ECO:0000269|PubMed:22560297, ECO:0000269|PubMed:22849347, ECO:0000269|PubMed:26926761, ECO:0000269|PubMed:29899023}. |
P08174 | CD55 | S138 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
Q9BUP3 | HTATIP2 | S177 | Sugiyama | Protein HTATIP2 (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2) | Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672). {ECO:0000250|UniProtKB:B0BNF8, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:18519672}. |
Q13111 | CHAF1A | S777 | Sugiyama | Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250|UniProtKB:Q5R1T0}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.000002 | 5.717 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.000013 | 4.890 |
R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.000070 | 4.153 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000320 | 3.495 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.000320 | 3.495 |
R-HSA-9827857 | Specification of primordial germ cells | 0.000691 | 3.161 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.000802 | 3.096 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.001054 | 2.977 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.001054 | 2.977 |
R-HSA-9834899 | Specification of the neural plate border | 0.000952 | 3.021 |
R-HSA-193648 | NRAGE signals death through JNK | 0.001085 | 2.965 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.002519 | 2.599 |
R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 0.003681 | 2.434 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.003278 | 2.484 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.003595 | 2.444 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.003779 | 2.423 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.003481 | 2.458 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.004638 | 2.334 |
R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.005239 | 2.281 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.005999 | 2.222 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.006442 | 2.191 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.009100 | 2.041 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.009362 | 2.029 |
R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.011384 | 1.944 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.010323 | 1.986 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.011464 | 1.941 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.010903 | 1.962 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.011753 | 1.930 |
R-HSA-73887 | Death Receptor Signaling | 0.012405 | 1.906 |
R-HSA-446107 | Type I hemidesmosome assembly | 0.016618 | 1.779 |
R-HSA-1483255 | PI Metabolism | 0.016182 | 1.791 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.018225 | 1.739 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.018225 | 1.739 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.018238 | 1.739 |
R-HSA-9700645 | ALK mutants bind TKIs | 0.019550 | 1.709 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.022682 | 1.644 |
R-HSA-162582 | Signal Transduction | 0.022607 | 1.646 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.025903 | 1.587 |
R-HSA-5602566 | TICAM1 deficiency - HSE | 0.034780 | 1.459 |
R-HSA-5602571 | TRAF3 deficiency - HSE | 0.051715 | 1.286 |
R-HSA-5674404 | PTEN Loss of Function in Cancer | 0.051715 | 1.286 |
R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.084703 | 1.072 |
R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.100765 | 0.997 |
R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.100765 | 0.997 |
R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.116547 | 0.933 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.132052 | 0.879 |
R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.132052 | 0.879 |
R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.132052 | 0.879 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.132052 | 0.879 |
R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.037049 | 1.431 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.147286 | 0.832 |
R-HSA-3656244 | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 0.147286 | 0.832 |
R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.147286 | 0.832 |
R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.147286 | 0.832 |
R-HSA-3656243 | Defective ST3GAL3 causes MCT12 and EIEE15 | 0.147286 | 0.832 |
R-HSA-3656225 | Defective CHST6 causes MCDC1 | 0.147286 | 0.832 |
R-HSA-8948747 | Regulation of PTEN localization | 0.162254 | 0.790 |
R-HSA-2562578 | TRIF-mediated programmed cell death | 0.162254 | 0.790 |
R-HSA-9732724 | IFNG signaling activates MAPKs | 0.162254 | 0.790 |
R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.162254 | 0.790 |
R-HSA-444257 | RSK activation | 0.176960 | 0.752 |
R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.176960 | 0.752 |
R-HSA-196025 | Formation of annular gap junctions | 0.176960 | 0.752 |
R-HSA-211957 | Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 | 0.176960 | 0.752 |
R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.176960 | 0.752 |
R-HSA-9613354 | Lipophagy | 0.191409 | 0.718 |
R-HSA-9020958 | Interleukin-21 signaling | 0.191409 | 0.718 |
R-HSA-190873 | Gap junction degradation | 0.191409 | 0.718 |
R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.205605 | 0.687 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.219552 | 0.658 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.044182 | 1.355 |
R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.233256 | 0.632 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.233256 | 0.632 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.057297 | 1.242 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.128208 | 0.892 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.072032 | 1.142 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.072032 | 1.142 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.072032 | 1.142 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.272944 | 0.564 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.041918 | 1.378 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.285714 | 0.544 |
R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.285714 | 0.544 |
R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.285714 | 0.544 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.285714 | 0.544 |
R-HSA-2142816 | Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) | 0.298259 | 0.525 |
R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.298259 | 0.525 |
R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.298259 | 0.525 |
R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.298259 | 0.525 |
R-HSA-1296072 | Voltage gated Potassium channels | 0.183477 | 0.736 |
R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.322696 | 0.491 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.346284 | 0.461 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.221942 | 0.654 |
R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.357769 | 0.446 |
R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.357769 | 0.446 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.196390 | 0.707 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.274012 | 0.562 |
R-HSA-912526 | Interleukin receptor SHC signaling | 0.401735 | 0.396 |
R-HSA-977068 | Termination of O-glycan biosynthesis | 0.401735 | 0.396 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.338794 | 0.470 |
R-HSA-9615710 | Late endosomal microautophagy | 0.462122 | 0.335 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.289706 | 0.538 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.356923 | 0.447 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.356923 | 0.447 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.413995 | 0.383 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.094116 | 1.026 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.237201 | 0.625 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.237201 | 0.625 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.432729 | 0.364 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.233256 | 0.632 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.310585 | 0.508 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.057297 | 1.242 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.237201 | 0.625 |
R-HSA-6802949 | Signaling by RAS mutants | 0.072032 | 1.142 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.045235 | 1.345 |
R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.176960 | 0.752 |
R-HSA-9839394 | TGFBR3 expression | 0.105163 | 0.978 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.310585 | 0.508 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.391033 | 0.408 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.294495 | 0.531 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.054541 | 1.263 |
R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.116547 | 0.933 |
R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.116547 | 0.933 |
R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.176960 | 0.752 |
R-HSA-2025928 | Calcineurin activates NFAT | 0.191409 | 0.718 |
R-HSA-5673000 | RAF activation | 0.037128 | 1.430 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.272944 | 0.564 |
R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.334594 | 0.475 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.270619 | 0.568 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.099596 | 1.002 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.404500 | 0.393 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.191331 | 0.718 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.041064 | 1.387 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.045235 | 1.345 |
R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.205605 | 0.687 |
R-HSA-9930044 | Nuclear RNA decay | 0.152291 | 0.817 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.442700 | 0.354 |
R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.191409 | 0.718 |
R-HSA-9733709 | Cardiogenesis | 0.152291 | 0.817 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.404500 | 0.393 |
R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 0.051715 | 1.286 |
R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.068355 | 1.165 |
R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.068355 | 1.165 |
R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.132052 | 0.879 |
R-HSA-209931 | Serotonin and melatonin biosynthesis | 0.049554 | 1.305 |
R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.162254 | 0.790 |
R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.162254 | 0.790 |
R-HSA-190370 | FGFR1b ligand binding and activation | 0.176960 | 0.752 |
R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.191409 | 0.718 |
R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.205605 | 0.687 |
R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.219552 | 0.658 |
R-HSA-75896 | Plasmalogen biosynthesis | 0.233256 | 0.632 |
R-HSA-209560 | NF-kB is activated and signals survival | 0.233256 | 0.632 |
R-HSA-8866427 | VLDLR internalisation and degradation | 0.246720 | 0.608 |
R-HSA-1482883 | Acyl chain remodeling of DAG and TAG | 0.259948 | 0.585 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.164642 | 0.783 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.177162 | 0.752 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.196201 | 0.707 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.334594 | 0.475 |
R-HSA-2142670 | Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | 0.334594 | 0.475 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.380140 | 0.420 |
R-HSA-437239 | Recycling pathway of L1 | 0.254447 | 0.594 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.391033 | 0.408 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.412249 | 0.385 |
R-HSA-8949613 | Cristae formation | 0.442700 | 0.354 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.357928 | 0.446 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.334594 | 0.475 |
R-HSA-202433 | Generation of second messenger molecules | 0.202604 | 0.693 |
R-HSA-201451 | Signaling by BMP | 0.442700 | 0.354 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.401733 | 0.396 |
R-HSA-170968 | Frs2-mediated activation | 0.259948 | 0.585 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.086622 | 1.062 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.308263 | 0.511 |
R-HSA-211000 | Gene Silencing by RNA | 0.352129 | 0.453 |
R-HSA-169893 | Prolonged ERK activation events | 0.298259 | 0.525 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.366496 | 0.436 |
R-HSA-9734767 | Developmental Cell Lineages | 0.237792 | 0.624 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.342530 | 0.465 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.327946 | 0.484 |
R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.162254 | 0.790 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.298259 | 0.525 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.412249 | 0.385 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.366496 | 0.436 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.072032 | 1.142 |
R-HSA-2132295 | MHC class II antigen presentation | 0.437204 | 0.359 |
R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.105163 | 0.978 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.413995 | 0.383 |
R-HSA-9754189 | Germ layer formation at gastrulation | 0.346284 | 0.461 |
R-HSA-1268020 | Mitochondrial protein import | 0.351571 | 0.454 |
R-HSA-5683057 | MAPK family signaling cascades | 0.119739 | 0.922 |
R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.132052 | 0.879 |
R-HSA-170984 | ARMS-mediated activation | 0.191409 | 0.718 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.219552 | 0.658 |
R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.233256 | 0.632 |
R-HSA-190373 | FGFR1c ligand binding and activation | 0.259948 | 0.585 |
R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.128208 | 0.892 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.272944 | 0.564 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.152291 | 0.817 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.310585 | 0.508 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.322696 | 0.491 |
R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.357769 | 0.446 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.369054 | 0.433 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.254447 | 0.594 |
R-HSA-420029 | Tight junction interactions | 0.422579 | 0.374 |
R-HSA-1474165 | Reproduction | 0.260106 | 0.585 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.432729 | 0.364 |
R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.105163 | 0.978 |
R-HSA-202403 | TCR signaling | 0.067428 | 1.171 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.319489 | 0.496 |
R-HSA-9033241 | Peroxisomal protein import | 0.332376 | 0.478 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.176960 | 0.752 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.147286 | 0.832 |
R-HSA-392517 | Rap1 signalling | 0.068194 | 1.166 |
R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.246720 | 0.608 |
R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.272944 | 0.564 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.152291 | 0.817 |
R-HSA-190242 | FGFR1 ligand binding and activation | 0.334594 | 0.475 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.202604 | 0.693 |
R-HSA-5260271 | Diseases of Immune System | 0.202604 | 0.693 |
R-HSA-2022857 | Keratan sulfate degradation | 0.357769 | 0.446 |
R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.442700 | 0.354 |
R-HSA-5334118 | DNA methylation | 0.462122 | 0.335 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.063342 | 1.198 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 0.072032 | 1.142 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.068960 | 1.161 |
R-HSA-877300 | Interferon gamma signaling | 0.382620 | 0.417 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.151935 | 0.818 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.151935 | 0.818 |
R-HSA-199991 | Membrane Trafficking | 0.299125 | 0.524 |
R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.132052 | 0.879 |
R-HSA-199920 | CREB phosphorylation | 0.147286 | 0.832 |
R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.162254 | 0.790 |
R-HSA-425986 | Sodium/Proton exchangers | 0.176960 | 0.752 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.191409 | 0.718 |
R-HSA-877312 | Regulation of IFNG signaling | 0.246720 | 0.608 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.259948 | 0.585 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.164642 | 0.783 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 0.346284 | 0.461 |
R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.412249 | 0.385 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.325941 | 0.487 |
R-HSA-9609507 | Protein localization | 0.358724 | 0.445 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.433949 | 0.363 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.205605 | 0.687 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.191409 | 0.718 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.298259 | 0.525 |
R-HSA-9664420 | Killing mechanisms | 0.298259 | 0.525 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.346284 | 0.461 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.376859 | 0.424 |
R-HSA-9612973 | Autophagy | 0.370679 | 0.431 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.158444 | 0.800 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.240661 | 0.619 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.346781 | 0.460 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.461724 | 0.336 |
R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.116547 | 0.933 |
R-HSA-448706 | Interleukin-1 processing | 0.191409 | 0.718 |
R-HSA-193692 | Regulated proteolysis of p75NTR | 0.191409 | 0.718 |
R-HSA-3000157 | Laminin interactions | 0.105163 | 0.978 |
R-HSA-8983711 | OAS antiviral response | 0.246720 | 0.608 |
R-HSA-9005895 | Pervasive developmental disorders | 0.246720 | 0.608 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.246720 | 0.608 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.246720 | 0.608 |
R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.272944 | 0.564 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.285714 | 0.544 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.152291 | 0.817 |
R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.322696 | 0.491 |
R-HSA-6811438 | Intra-Golgi traffic | 0.215477 | 0.667 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.357769 | 0.446 |
R-HSA-8848584 | Wax and plasmalogen biosynthesis | 0.357769 | 0.446 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.228317 | 0.641 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.420079 | 0.377 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.444085 | 0.353 |
R-HSA-69206 | G1/S Transition | 0.451017 | 0.346 |
R-HSA-70268 | Pyruvate metabolism | 0.242291 | 0.616 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.234915 | 0.629 |
R-HSA-5362517 | Signaling by Retinoic Acid | 0.033742 | 1.472 |
R-HSA-4839726 | Chromatin organization | 0.107841 | 0.967 |
R-HSA-9006936 | Signaling by TGFB family members | 0.040747 | 1.390 |
R-HSA-451927 | Interleukin-2 family signaling | 0.202604 | 0.693 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.146187 | 0.835 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.285714 | 0.544 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.285714 | 0.544 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.322696 | 0.491 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.209030 | 0.680 |
R-HSA-449836 | Other interleukin signaling | 0.346284 | 0.461 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.323306 | 0.490 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.152291 | 0.817 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.073164 | 1.136 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.083436 | 1.079 |
R-HSA-5578768 | Physiological factors | 0.272944 | 0.564 |
R-HSA-9018681 | Biosynthesis of protectins | 0.272944 | 0.564 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.298259 | 0.525 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.310585 | 0.508 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.334594 | 0.475 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.442700 | 0.354 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.112094 | 0.950 |
R-HSA-1632852 | Macroautophagy | 0.307030 | 0.513 |
R-HSA-193639 | p75NTR signals via NF-kB | 0.285714 | 0.544 |
R-HSA-9758941 | Gastrulation | 0.176438 | 0.753 |
R-HSA-168255 | Influenza Infection | 0.274786 | 0.561 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.128687 | 0.890 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.183066 | 0.737 |
R-HSA-9020956 | Interleukin-27 signaling | 0.205605 | 0.687 |
R-HSA-8964038 | LDL clearance | 0.391033 | 0.408 |
R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.401735 | 0.396 |
R-HSA-5689880 | Ub-specific processing proteases | 0.128004 | 0.893 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.401733 | 0.396 |
R-HSA-446728 | Cell junction organization | 0.085531 | 1.068 |
R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.132052 | 0.879 |
R-HSA-6814848 | Glycerophospholipid catabolism | 0.272944 | 0.564 |
R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.310585 | 0.508 |
R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.322696 | 0.491 |
R-HSA-198753 | ERK/MAPK targets | 0.369054 | 0.433 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.380140 | 0.420 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.232958 | 0.633 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.270619 | 0.568 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.452497 | 0.344 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.462122 | 0.335 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.462122 | 0.335 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.413905 | 0.383 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.166828 | 0.778 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.234915 | 0.629 |
R-HSA-156711 | Polo-like kinase mediated events | 0.063342 | 1.198 |
R-HSA-1500931 | Cell-Cell communication | 0.145105 | 0.838 |
R-HSA-9683686 | Maturation of spike protein | 0.205605 | 0.687 |
R-HSA-389599 | Alpha-oxidation of phytanate | 0.422579 | 0.374 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.462122 | 0.335 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.323306 | 0.490 |
R-HSA-2559583 | Cellular Senescence | 0.278151 | 0.556 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.332907 | 0.478 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.254795 | 0.594 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.254795 | 0.594 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.395051 | 0.403 |
R-HSA-166520 | Signaling by NTRKs | 0.076760 | 1.115 |
R-HSA-1266738 | Developmental Biology | 0.249415 | 0.603 |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.272944 | 0.564 |
R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.298259 | 0.525 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.351571 | 0.454 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.409208 | 0.388 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.299289 | 0.524 |
R-HSA-421270 | Cell-cell junction organization | 0.348041 | 0.458 |
R-HSA-5654738 | Signaling by FGFR2 | 0.461724 | 0.336 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.437204 | 0.359 |
R-HSA-418990 | Adherens junctions interactions | 0.412860 | 0.384 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.169999 | 0.770 |
R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.391033 | 0.408 |
R-HSA-5654736 | Signaling by FGFR1 | 0.105900 | 0.975 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.083436 | 1.079 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.259948 | 0.585 |
R-HSA-210991 | Basigin interactions | 0.369054 | 0.433 |
R-HSA-9865881 | Complex III assembly | 0.412249 | 0.385 |
R-HSA-73614 | Pyrimidine salvage | 0.452497 | 0.344 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.356923 | 0.447 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.313024 | 0.504 |
R-HSA-209776 | Metabolism of amine-derived hormones | 0.313024 | 0.504 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.209942 | 0.678 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.099596 | 1.002 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.099596 | 1.002 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.432729 | 0.364 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.261129 | 0.583 |
R-HSA-5688426 | Deubiquitination | 0.360529 | 0.443 |
R-HSA-9007101 | Rab regulation of trafficking | 0.409208 | 0.388 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.116539 | 0.934 |
R-HSA-418885 | DCC mediated attractive signaling | 0.285714 | 0.544 |
R-HSA-8853659 | RET signaling | 0.177162 | 0.752 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.334594 | 0.475 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.169999 | 0.770 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.193068 | 0.714 |
R-HSA-422475 | Axon guidance | 0.303170 | 0.518 |
R-HSA-9645723 | Diseases of programmed cell death | 0.246980 | 0.607 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.361712 | 0.442 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.442700 | 0.354 |
R-HSA-8984722 | Interleukin-35 Signalling | 0.246720 | 0.608 |
R-HSA-9018682 | Biosynthesis of maresins | 0.401735 | 0.396 |
R-HSA-5669034 | TNFs bind their physiological receptors | 0.412249 | 0.385 |
R-HSA-9675108 | Nervous system development | 0.380905 | 0.419 |
R-HSA-1538133 | G0 and Early G1 | 0.146187 | 0.835 |
R-HSA-1483257 | Phospholipid metabolism | 0.325121 | 0.488 |
R-HSA-210993 | Tie2 Signaling | 0.334594 | 0.475 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.391033 | 0.408 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.401733 | 0.396 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.380809 | 0.419 |
R-HSA-3000170 | Syndecan interactions | 0.094116 | 1.026 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.452497 | 0.344 |
R-HSA-177929 | Signaling by EGFR | 0.313024 | 0.504 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.401733 | 0.396 |
R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.116547 | 0.933 |
R-HSA-373752 | Netrin-1 signaling | 0.234915 | 0.629 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.432729 | 0.364 |
R-HSA-264876 | Insulin processing | 0.442700 | 0.354 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.088728 | 1.052 |
R-HSA-190236 | Signaling by FGFR | 0.129689 | 0.887 |
R-HSA-9694301 | Maturation of replicase proteins | 0.162254 | 0.790 |
R-HSA-844456 | The NLRP3 inflammasome | 0.346284 | 0.461 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.401735 | 0.396 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.100485 | 0.998 |
R-HSA-69242 | S Phase | 0.338798 | 0.470 |
R-HSA-9031628 | NGF-stimulated transcription | 0.260968 | 0.583 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.407879 | 0.389 |
R-HSA-447115 | Interleukin-12 family signaling | 0.242291 | 0.616 |
R-HSA-168268 | Virus Assembly and Release | 0.298259 | 0.525 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.332376 | 0.478 |
R-HSA-622312 | Inflammasomes | 0.452497 | 0.344 |
R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.334594 | 0.475 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.370573 | 0.431 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.325941 | 0.487 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.228422 | 0.641 |
R-HSA-9020591 | Interleukin-12 signaling | 0.438134 | 0.358 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 0.308888 | 0.510 |
R-HSA-194068 | Bile acid and bile salt metabolism | 0.366496 | 0.436 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.471579 | 0.326 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.471579 | 0.326 |
R-HSA-2424491 | DAP12 signaling | 0.471579 | 0.326 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.471579 | 0.326 |
R-HSA-114452 | Activation of BH3-only proteins | 0.471579 | 0.326 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.473301 | 0.325 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.480870 | 0.318 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.480870 | 0.318 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.480870 | 0.318 |
R-HSA-186763 | Downstream signal transduction | 0.480870 | 0.318 |
R-HSA-182971 | EGFR downregulation | 0.480870 | 0.318 |
R-HSA-9843745 | Adipogenesis | 0.482687 | 0.316 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.484727 | 0.315 |
R-HSA-69275 | G2/M Transition | 0.491613 | 0.308 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.498966 | 0.302 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.498966 | 0.302 |
R-HSA-2022854 | Keratan sulfate biosynthesis | 0.498966 | 0.302 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.498966 | 0.302 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.498966 | 0.302 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.498966 | 0.302 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.498966 | 0.302 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.498966 | 0.302 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.498966 | 0.302 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.498966 | 0.302 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.498966 | 0.302 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.499126 | 0.302 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.501575 | 0.300 |
R-HSA-438064 | Post NMDA receptor activation events | 0.507113 | 0.295 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.507777 | 0.294 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.507777 | 0.294 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.507777 | 0.294 |
R-HSA-5223345 | Miscellaneous transport and binding events | 0.507777 | 0.294 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.509130 | 0.293 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.510305 | 0.292 |
R-HSA-156902 | Peptide chain elongation | 0.512610 | 0.290 |
R-HSA-9663891 | Selective autophagy | 0.512610 | 0.290 |
R-HSA-180746 | Nuclear import of Rev protein | 0.516434 | 0.287 |
R-HSA-901042 | Calnexin/calreticulin cycle | 0.516434 | 0.287 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.516434 | 0.287 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.516434 | 0.287 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.516434 | 0.287 |
R-HSA-5205647 | Mitophagy | 0.516434 | 0.287 |
R-HSA-6807070 | PTEN Regulation | 0.522085 | 0.282 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.523482 | 0.281 |
R-HSA-202424 | Downstream TCR signaling | 0.523482 | 0.281 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.524938 | 0.280 |
R-HSA-187687 | Signalling to ERKs | 0.524938 | 0.280 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.524938 | 0.280 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.524938 | 0.280 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.524938 | 0.280 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.528857 | 0.277 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.533294 | 0.273 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.533294 | 0.273 |
R-HSA-111933 | Calmodulin induced events | 0.533294 | 0.273 |
R-HSA-111997 | CaM pathway | 0.533294 | 0.273 |
R-HSA-163560 | Triglyceride catabolism | 0.533294 | 0.273 |
R-HSA-69205 | G1/S-Specific Transcription | 0.533294 | 0.273 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.534191 | 0.272 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.541504 | 0.266 |
R-HSA-419037 | NCAM1 interactions | 0.541504 | 0.266 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.541504 | 0.266 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.549569 | 0.260 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.549944 | 0.260 |
R-HSA-1474290 | Collagen formation | 0.549944 | 0.260 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.555112 | 0.256 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.555698 | 0.255 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.557493 | 0.254 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.557493 | 0.254 |
R-HSA-69541 | Stabilization of p53 | 0.557493 | 0.254 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.557493 | 0.254 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.557493 | 0.254 |
R-HSA-8964043 | Plasma lipoprotein clearance | 0.557493 | 0.254 |
R-HSA-201556 | Signaling by ALK | 0.557493 | 0.254 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.558870 | 0.253 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.560237 | 0.252 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.560237 | 0.252 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.563879 | 0.249 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.565278 | 0.248 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.565278 | 0.248 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.565278 | 0.248 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.565278 | 0.248 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.565278 | 0.248 |
R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.565278 | 0.248 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.565320 | 0.248 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.565320 | 0.248 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.565320 | 0.248 |
R-HSA-1296071 | Potassium Channels | 0.565320 | 0.248 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.572927 | 0.242 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.572927 | 0.242 |
R-HSA-5423646 | Aflatoxin activation and detoxification | 0.572927 | 0.242 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.572927 | 0.242 |
R-HSA-9694548 | Maturation of spike protein | 0.572927 | 0.242 |
R-HSA-9607240 | FLT3 Signaling | 0.572927 | 0.242 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.575360 | 0.240 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.575360 | 0.240 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.575360 | 0.240 |
R-HSA-3214847 | HATs acetylate histones | 0.580316 | 0.236 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.580441 | 0.236 |
R-HSA-9683701 | Translation of Structural Proteins | 0.580441 | 0.236 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.587824 | 0.231 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.587824 | 0.231 |
R-HSA-111996 | Ca-dependent events | 0.587824 | 0.231 |
R-HSA-2408557 | Selenocysteine synthesis | 0.590102 | 0.229 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.591782 | 0.228 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.594930 | 0.226 |
R-HSA-9710421 | Defective pyroptosis | 0.595077 | 0.225 |
R-HSA-5654743 | Signaling by FGFR4 | 0.595077 | 0.225 |
R-HSA-192823 | Viral mRNA Translation | 0.599717 | 0.222 |
R-HSA-2172127 | DAP12 interactions | 0.602203 | 0.220 |
R-HSA-190828 | Gap junction trafficking | 0.602203 | 0.220 |
R-HSA-156581 | Methylation | 0.602203 | 0.220 |
R-HSA-5683826 | Surfactant metabolism | 0.602203 | 0.220 |
R-HSA-9711097 | Cellular response to starvation | 0.603383 | 0.219 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.604460 | 0.219 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.604460 | 0.219 |
R-HSA-5653656 | Vesicle-mediated transport | 0.609196 | 0.215 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.609205 | 0.215 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.609205 | 0.215 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.609205 | 0.215 |
R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.609205 | 0.215 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.609205 | 0.215 |
R-HSA-1489509 | DAG and IP3 signaling | 0.609205 | 0.215 |
R-HSA-5654741 | Signaling by FGFR3 | 0.609205 | 0.215 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.610996 | 0.214 |
R-HSA-74160 | Gene expression (Transcription) | 0.613669 | 0.212 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.613820 | 0.212 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.616083 | 0.210 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.616083 | 0.210 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.616083 | 0.210 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.616083 | 0.210 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.616083 | 0.210 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.619656 | 0.208 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.622841 | 0.206 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.622841 | 0.206 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.623010 | 0.206 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.625928 | 0.203 |
R-HSA-2672351 | Stimuli-sensing channels | 0.627542 | 0.202 |
R-HSA-389356 | Co-stimulation by CD28 | 0.629480 | 0.201 |
R-HSA-425410 | Metal ion SLC transporters | 0.629480 | 0.201 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.634293 | 0.198 |
R-HSA-1638074 | Keratan sulfate/keratin metabolism | 0.636002 | 0.197 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.636002 | 0.197 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.636002 | 0.197 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.636002 | 0.197 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.636002 | 0.197 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.636002 | 0.197 |
R-HSA-109704 | PI3K Cascade | 0.642411 | 0.192 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.645246 | 0.190 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.645246 | 0.190 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.645246 | 0.190 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.648706 | 0.188 |
R-HSA-68949 | Orc1 removal from chromatin | 0.654892 | 0.184 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.654892 | 0.184 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.654892 | 0.184 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.656432 | 0.183 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.658071 | 0.182 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.660969 | 0.180 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.660969 | 0.180 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.660969 | 0.180 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.666435 | 0.176 |
R-HSA-909733 | Interferon alpha/beta signaling | 0.666435 | 0.176 |
R-HSA-72649 | Translation initiation complex formation | 0.666939 | 0.176 |
R-HSA-8939211 | ESR-mediated signaling | 0.667894 | 0.175 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.668334 | 0.175 |
R-HSA-373760 | L1CAM interactions | 0.670548 | 0.174 |
R-HSA-3214815 | HDACs deacetylate histones | 0.672804 | 0.172 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.678567 | 0.168 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.678567 | 0.168 |
R-HSA-75893 | TNF signaling | 0.678567 | 0.168 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.678567 | 0.168 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.682643 | 0.166 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.682643 | 0.166 |
R-HSA-112399 | IRS-mediated signalling | 0.684228 | 0.165 |
R-HSA-5621480 | Dectin-2 family | 0.684228 | 0.165 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.684228 | 0.165 |
R-HSA-68875 | Mitotic Prophase | 0.686594 | 0.163 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.689790 | 0.161 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.689790 | 0.161 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.694374 | 0.158 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.694374 | 0.158 |
R-HSA-191859 | snRNP Assembly | 0.695254 | 0.158 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.695254 | 0.158 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.695254 | 0.158 |
R-HSA-8979227 | Triglyceride metabolism | 0.695254 | 0.158 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.700623 | 0.155 |
R-HSA-379724 | tRNA Aminoacylation | 0.700623 | 0.155 |
R-HSA-983189 | Kinesins | 0.700623 | 0.155 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.700623 | 0.155 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.700623 | 0.155 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.700623 | 0.155 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.700623 | 0.155 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.700623 | 0.155 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.700623 | 0.155 |
R-HSA-1227986 | Signaling by ERBB2 | 0.700623 | 0.155 |
R-HSA-162909 | Host Interactions of HIV factors | 0.701995 | 0.154 |
R-HSA-977606 | Regulation of Complement cascade | 0.705746 | 0.151 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.705897 | 0.151 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.705897 | 0.151 |
R-HSA-112043 | PLC beta mediated events | 0.705897 | 0.151 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.705897 | 0.151 |
R-HSA-450294 | MAP kinase activation | 0.705897 | 0.151 |
R-HSA-8956321 | Nucleotide salvage | 0.705897 | 0.151 |
R-HSA-1280218 | Adaptive Immune System | 0.706770 | 0.151 |
R-HSA-9707616 | Heme signaling | 0.711078 | 0.148 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.711078 | 0.148 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 0.711078 | 0.148 |
R-HSA-186797 | Signaling by PDGF | 0.711078 | 0.148 |
R-HSA-983712 | Ion channel transport | 0.713254 | 0.147 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.713845 | 0.146 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.716169 | 0.145 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.716169 | 0.145 |
R-HSA-5617833 | Cilium Assembly | 0.716276 | 0.145 |
R-HSA-69481 | G2/M Checkpoints | 0.716763 | 0.145 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.720822 | 0.142 |
R-HSA-211981 | Xenobiotics | 0.721170 | 0.142 |
R-HSA-2428924 | IGF1R signaling cascade | 0.721170 | 0.142 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.721170 | 0.142 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.721170 | 0.142 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.721170 | 0.142 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.726014 | 0.139 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.726084 | 0.139 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.727433 | 0.138 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.730911 | 0.136 |
R-HSA-5576891 | Cardiac conduction | 0.734357 | 0.134 |
R-HSA-112040 | G-protein mediated events | 0.735653 | 0.133 |
R-HSA-9909396 | Circadian clock | 0.737762 | 0.132 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.737762 | 0.132 |
R-HSA-913709 | O-linked glycosylation of mucins | 0.740312 | 0.131 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.740312 | 0.131 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.740312 | 0.131 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.745155 | 0.128 |
R-HSA-448424 | Interleukin-17 signaling | 0.749386 | 0.125 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.753350 | 0.123 |
R-HSA-376176 | Signaling by ROBO receptors | 0.753350 | 0.123 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.753804 | 0.123 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.753804 | 0.123 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.753804 | 0.123 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.753804 | 0.123 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.753804 | 0.123 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.754236 | 0.122 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.758599 | 0.120 |
R-HSA-9948299 | Ribosome-associated quality control | 0.760573 | 0.119 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.762408 | 0.118 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.762408 | 0.118 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.762408 | 0.118 |
R-HSA-4086398 | Ca2+ pathway | 0.762408 | 0.118 |
R-HSA-1236394 | Signaling by ERBB4 | 0.766597 | 0.115 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.766597 | 0.115 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.766826 | 0.115 |
R-HSA-380287 | Centrosome maturation | 0.770713 | 0.113 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.770713 | 0.113 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.770713 | 0.113 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.770713 | 0.113 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.770713 | 0.113 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.774756 | 0.111 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.775800 | 0.110 |
R-HSA-9694635 | Translation of Structural Proteins | 0.778728 | 0.109 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.778742 | 0.109 |
R-HSA-4086400 | PCP/CE pathway | 0.782630 | 0.106 |
R-HSA-216083 | Integrin cell surface interactions | 0.782630 | 0.106 |
R-HSA-166658 | Complement cascade | 0.784526 | 0.105 |
R-HSA-9659379 | Sensory processing of sound | 0.786464 | 0.104 |
R-HSA-68882 | Mitotic Anaphase | 0.788831 | 0.103 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.790176 | 0.102 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.790230 | 0.102 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.791196 | 0.102 |
R-HSA-977225 | Amyloid fiber formation | 0.793930 | 0.100 |
R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.793930 | 0.100 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.797565 | 0.098 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.801137 | 0.096 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.801137 | 0.096 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.803736 | 0.095 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.804645 | 0.094 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.804645 | 0.094 |
R-HSA-390918 | Peroxisomal lipid metabolism | 0.804645 | 0.094 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.808092 | 0.093 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.808939 | 0.092 |
R-HSA-72766 | Translation | 0.809366 | 0.092 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.811478 | 0.091 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.811478 | 0.091 |
R-HSA-1989781 | PPARA activates gene expression | 0.811494 | 0.091 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.814804 | 0.089 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.816514 | 0.088 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.818073 | 0.087 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.818978 | 0.087 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.821283 | 0.086 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.823604 | 0.084 |
R-HSA-73884 | Base Excision Repair | 0.827536 | 0.082 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.827536 | 0.082 |
R-HSA-109581 | Apoptosis | 0.828544 | 0.082 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.830580 | 0.081 |
R-HSA-1640170 | Cell Cycle | 0.833756 | 0.079 |
R-HSA-388396 | GPCR downstream signalling | 0.835594 | 0.078 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.836509 | 0.078 |
R-HSA-391251 | Protein folding | 0.836509 | 0.078 |
R-HSA-74752 | Signaling by Insulin receptor | 0.836509 | 0.078 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.836509 | 0.078 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.839395 | 0.076 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.842231 | 0.075 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.843683 | 0.074 |
R-HSA-913531 | Interferon Signaling | 0.843683 | 0.074 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.845016 | 0.073 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.848426 | 0.071 |
R-HSA-5389840 | Mitochondrial translation elongation | 0.850441 | 0.070 |
R-HSA-418555 | G alpha (s) signalling events | 0.850501 | 0.070 |
R-HSA-372790 | Signaling by GPCR | 0.855672 | 0.068 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.855677 | 0.068 |
R-HSA-5368286 | Mitochondrial translation initiation | 0.855677 | 0.068 |
R-HSA-212436 | Generic Transcription Pathway | 0.857806 | 0.067 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.860730 | 0.065 |
R-HSA-70171 | Glycolysis | 0.860730 | 0.065 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.863190 | 0.064 |
R-HSA-9020702 | Interleukin-1 signaling | 0.863190 | 0.064 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.865607 | 0.063 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.867981 | 0.061 |
R-HSA-111885 | Opioid Signalling | 0.870314 | 0.060 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.870314 | 0.060 |
R-HSA-3781865 | Diseases of glycosylation | 0.875222 | 0.058 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.877068 | 0.057 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.877470 | 0.057 |
R-HSA-69239 | Synthesis of DNA | 0.879240 | 0.056 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.882037 | 0.055 |
R-HSA-5419276 | Mitochondrial translation termination | 0.883471 | 0.054 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.883471 | 0.054 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.883471 | 0.054 |
R-HSA-449147 | Signaling by Interleukins | 0.887583 | 0.052 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.889542 | 0.051 |
R-HSA-68877 | Mitotic Prometaphase | 0.890074 | 0.051 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.891494 | 0.050 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.891619 | 0.050 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.893001 | 0.049 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.893413 | 0.049 |
R-HSA-9609690 | HCMV Early Events | 0.894650 | 0.048 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.895297 | 0.048 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.900035 | 0.046 |
R-HSA-9658195 | Leishmania infection | 0.902491 | 0.045 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.902491 | 0.045 |
R-HSA-70326 | Glucose metabolism | 0.902509 | 0.045 |
R-HSA-2980736 | Peptide hormone metabolism | 0.902509 | 0.045 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.903276 | 0.044 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.903699 | 0.044 |
R-HSA-5693538 | Homology Directed Repair | 0.904233 | 0.044 |
R-HSA-72172 | mRNA Splicing | 0.907338 | 0.042 |
R-HSA-5357801 | Programmed Cell Death | 0.908657 | 0.042 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.909226 | 0.041 |
R-HSA-3371556 | Cellular response to heat stress | 0.909226 | 0.041 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.909226 | 0.041 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.912409 | 0.040 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.917406 | 0.037 |
R-HSA-397014 | Muscle contraction | 0.917406 | 0.037 |
R-HSA-195721 | Signaling by WNT | 0.921272 | 0.036 |
R-HSA-6798695 | Neutrophil degranulation | 0.926844 | 0.033 |
R-HSA-68886 | M Phase | 0.927390 | 0.033 |
R-HSA-162906 | HIV Infection | 0.933577 | 0.030 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.934541 | 0.029 |
R-HSA-112316 | Neuronal System | 0.935089 | 0.029 |
R-HSA-5173105 | O-linked glycosylation | 0.935345 | 0.029 |
R-HSA-5368287 | Mitochondrial translation | 0.936490 | 0.028 |
R-HSA-72312 | rRNA processing | 0.938268 | 0.028 |
R-HSA-9664407 | Parasite infection | 0.938720 | 0.027 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.938720 | 0.027 |
R-HSA-9664417 | Leishmania phagocytosis | 0.938720 | 0.027 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.939806 | 0.027 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.941920 | 0.026 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.942644 | 0.026 |
R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.942949 | 0.026 |
R-HSA-8957322 | Metabolism of steroids | 0.943693 | 0.025 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.943960 | 0.025 |
R-HSA-157118 | Signaling by NOTCH | 0.945127 | 0.025 |
R-HSA-1474244 | Extracellular matrix organization | 0.948631 | 0.023 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.950553 | 0.022 |
R-HSA-2142753 | Arachidonate metabolism | 0.951430 | 0.022 |
R-HSA-446652 | Interleukin-1 family signaling | 0.951430 | 0.022 |
R-HSA-69306 | DNA Replication | 0.952291 | 0.021 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.952291 | 0.021 |
R-HSA-9609646 | HCMV Infection | 0.952687 | 0.021 |
R-HSA-9610379 | HCMV Late Events | 0.955586 | 0.020 |
R-HSA-162587 | HIV Life Cycle | 0.955586 | 0.020 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.960816 | 0.017 |
R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.962865 | 0.016 |
R-HSA-5619102 | SLC transporter disorders | 0.962865 | 0.016 |
R-HSA-9711123 | Cellular response to chemical stress | 0.963861 | 0.016 |
R-HSA-72306 | tRNA processing | 0.965432 | 0.015 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.967822 | 0.014 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.968393 | 0.014 |
R-HSA-611105 | Respiratory electron transport | 0.970047 | 0.013 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.972614 | 0.012 |
R-HSA-375276 | Peptide ligand-binding receptors | 0.974048 | 0.011 |
R-HSA-9679506 | SARS-CoV Infections | 0.976063 | 0.011 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 0.977109 | 0.010 |
R-HSA-428157 | Sphingolipid metabolism | 0.980169 | 0.009 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.980868 | 0.008 |
R-HSA-597592 | Post-translational protein modification | 0.980973 | 0.008 |
R-HSA-392499 | Metabolism of proteins | 0.983995 | 0.007 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.984419 | 0.007 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.985388 | 0.006 |
R-HSA-8953854 | Metabolism of RNA | 0.985520 | 0.006 |
R-HSA-556833 | Metabolism of lipids | 0.985659 | 0.006 |
R-HSA-5668914 | Diseases of metabolism | 0.986385 | 0.006 |
R-HSA-168256 | Immune System | 0.987917 | 0.005 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.988943 | 0.005 |
R-HSA-2262752 | Cellular responses to stress | 0.989561 | 0.005 |
R-HSA-15869 | Metabolism of nucleotides | 0.989613 | 0.005 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.990159 | 0.004 |
R-HSA-168249 | Innate Immune System | 0.991129 | 0.004 |
R-HSA-73894 | DNA Repair | 0.991268 | 0.004 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.991478 | 0.004 |
R-HSA-416476 | G alpha (q) signalling events | 0.993725 | 0.003 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.994760 | 0.002 |
R-HSA-211945 | Phase I - Functionalization of compounds | 0.995125 | 0.002 |
R-HSA-418594 | G alpha (i) signalling events | 0.995933 | 0.002 |
R-HSA-8978868 | Fatty acid metabolism | 0.995933 | 0.002 |
R-HSA-9824446 | Viral Infection Pathways | 0.996774 | 0.001 |
R-HSA-1643685 | Disease | 0.997101 | 0.001 |
R-HSA-8953897 | Cellular responses to stimuli | 0.997365 | 0.001 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.998129 | 0.001 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.999413 | 0.000 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.999445 | 0.000 |
R-HSA-109582 | Hemostasis | 0.999693 | 0.000 |
R-HSA-382551 | Transport of small molecules | 0.999710 | 0.000 |
R-HSA-500792 | GPCR ligand binding | 0.999797 | 0.000 |
R-HSA-211859 | Biological oxidations | 0.999944 | 0.000 |
R-HSA-5663205 | Infectious disease | 0.999975 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
PRKD2 |
0.793 | 0.585 | -3 | 0.597 |
SRPK2 |
0.788 | 0.562 | -3 | 0.771 |
PRKD3 |
0.786 | 0.591 | -3 | 0.648 |
SBK |
0.785 | 0.636 | -3 | 0.835 |
MAPKAPK2 |
0.784 | 0.549 | -3 | 0.654 |
CDKL5 |
0.782 | 0.530 | -3 | 0.621 |
AKT2 |
0.781 | 0.578 | -3 | 0.745 |
RSK2 |
0.780 | 0.535 | -3 | 0.653 |
RSK3 |
0.780 | 0.546 | -3 | 0.650 |
MAPKAPK3 |
0.780 | 0.558 | -3 | 0.564 |
SRPK1 |
0.779 | 0.523 | -3 | 0.691 |
PRKX |
0.779 | 0.491 | -3 | 0.689 |
PRKD1 |
0.779 | 0.498 | -3 | 0.488 |
P90RSK |
0.778 | 0.557 | -3 | 0.653 |
SGK1 |
0.777 | 0.594 | -3 | 0.814 |
AKT3 |
0.777 | 0.558 | -3 | 0.803 |
CHK2 |
0.776 | 0.623 | -3 | 0.768 |
HIPK4 |
0.776 | 0.465 | 1 | 0.720 |
CDKL1 |
0.775 | 0.597 | -3 | 0.598 |
PKACA |
0.774 | 0.462 | -2 | 0.705 |
CAMK1A |
0.774 | 0.565 | -3 | 0.734 |
RSK4 |
0.774 | 0.504 | -3 | 0.684 |
CAMK1D |
0.774 | 0.565 | -3 | 0.692 |
SIK |
0.773 | 0.501 | -3 | 0.576 |
PIM1 |
0.773 | 0.539 | -3 | 0.616 |
PKACB |
0.773 | 0.443 | -2 | 0.746 |
AMPKA2 |
0.772 | 0.495 | -3 | 0.498 |
MSK2 |
0.771 | 0.516 | -3 | 0.668 |
CLK1 |
0.769 | 0.476 | -3 | 0.653 |
AKT1 |
0.769 | 0.515 | -3 | 0.704 |
MSK1 |
0.769 | 0.469 | -3 | 0.655 |
PIM2 |
0.768 | 0.547 | -3 | 0.669 |
P70S6KB |
0.768 | 0.497 | -3 | 0.581 |
P70S6K |
0.768 | 0.529 | -3 | 0.691 |
PIM3 |
0.767 | 0.486 | -3 | 0.517 |
BRSK1 |
0.767 | 0.414 | -3 | 0.552 |
SRPK3 |
0.767 | 0.490 | -3 | 0.695 |
CLK4 |
0.766 | 0.474 | -3 | 0.645 |
AMPKA1 |
0.765 | 0.454 | -3 | 0.432 |
SGK3 |
0.763 | 0.469 | -3 | 0.598 |
PKACG |
0.763 | 0.388 | -2 | 0.808 |
NUAK1 |
0.763 | 0.439 | -3 | 0.559 |
NDR1 |
0.762 | 0.388 | -3 | 0.476 |
NDR2 |
0.762 | 0.328 | -3 | 0.438 |
ICK |
0.762 | 0.484 | -3 | 0.529 |
QSK |
0.762 | 0.396 | 4 | 0.918 |
NUAK2 |
0.761 | 0.435 | -3 | 0.500 |
MAPKAPK5 |
0.761 | 0.541 | -3 | 0.646 |
AURC |
0.761 | 0.280 | -2 | 0.743 |
MELK |
0.761 | 0.440 | -3 | 0.514 |
DYRK1A |
0.760 | 0.429 | 1 | 0.671 |
CAMK1B |
0.759 | 0.505 | -3 | 0.448 |
CAMK1G |
0.759 | 0.473 | -3 | 0.624 |
MYLK4 |
0.759 | 0.418 | -2 | 0.830 |
PKN3 |
0.758 | 0.386 | -3 | 0.489 |
PKG2 |
0.758 | 0.343 | -2 | 0.752 |
BRSK2 |
0.757 | 0.326 | -3 | 0.464 |
CLK2 |
0.757 | 0.435 | -3 | 0.681 |
CRIK |
0.756 | 0.563 | -3 | 0.721 |
PKN1 |
0.755 | 0.455 | -3 | 0.662 |
LATS2 |
0.755 | 0.293 | -5 | 0.815 |
TSSK1 |
0.753 | 0.323 | -3 | 0.410 |
PKG1 |
0.753 | 0.400 | -2 | 0.680 |
HIPK2 |
0.753 | 0.316 | 1 | 0.557 |
MRCKB |
0.753 | 0.489 | -3 | 0.636 |
HIPK1 |
0.753 | 0.365 | 1 | 0.652 |
AURB |
0.753 | 0.269 | -2 | 0.736 |
CAMK4 |
0.753 | 0.361 | -3 | 0.458 |
DYRK3 |
0.752 | 0.399 | 1 | 0.660 |
PHKG1 |
0.751 | 0.335 | -3 | 0.471 |
MAK |
0.751 | 0.424 | -2 | 0.801 |
CAMK2A |
0.749 | 0.329 | 2 | 0.158 |
PAK1 |
0.749 | 0.274 | -2 | 0.841 |
HIPK3 |
0.749 | 0.358 | 1 | 0.671 |
PKN2 |
0.748 | 0.310 | -3 | 0.433 |
MOK |
0.748 | 0.459 | 1 | 0.681 |
DCAMKL1 |
0.748 | 0.444 | -3 | 0.553 |
CAMK2D |
0.748 | 0.298 | -3 | 0.418 |
PAK6 |
0.748 | 0.200 | -2 | 0.764 |
SKMLCK |
0.748 | 0.323 | -2 | 0.890 |
CDC7 |
0.747 | 0.202 | 1 | 0.784 |
PAK3 |
0.747 | 0.258 | -2 | 0.833 |
CAMLCK |
0.747 | 0.404 | -2 | 0.879 |
CLK3 |
0.747 | 0.273 | 1 | 0.743 |
DAPK2 |
0.746 | 0.470 | -3 | 0.412 |
MRCKA |
0.746 | 0.474 | -3 | 0.603 |
PKCD |
0.746 | 0.271 | 2 | 0.136 |
QIK |
0.746 | 0.313 | -3 | 0.405 |
MARK4 |
0.745 | 0.220 | 4 | 0.920 |
DCAMKL2 |
0.743 | 0.342 | -3 | 0.521 |
DYRK2 |
0.743 | 0.258 | 1 | 0.645 |
CHK1 |
0.743 | 0.324 | -3 | 0.403 |
MNK2 |
0.742 | 0.204 | -2 | 0.830 |
NIM1 |
0.741 | 0.223 | 3 | 0.813 |
CAMK2B |
0.741 | 0.254 | 2 | 0.137 |
TSSK2 |
0.741 | 0.234 | -5 | 0.938 |
MARK3 |
0.741 | 0.248 | 4 | 0.888 |
PAK2 |
0.739 | 0.253 | -2 | 0.828 |
PAK5 |
0.739 | 0.248 | -2 | 0.716 |
SNRK |
0.739 | 0.242 | 2 | 0.099 |
MARK1 |
0.739 | 0.261 | 4 | 0.901 |
SMMLCK |
0.738 | 0.438 | -3 | 0.526 |
ROCK2 |
0.738 | 0.457 | -3 | 0.557 |
DAPK3 |
0.738 | 0.453 | -3 | 0.568 |
PHKG2 |
0.737 | 0.298 | -3 | 0.494 |
PAK4 |
0.737 | 0.226 | -2 | 0.726 |
MNK1 |
0.737 | 0.208 | -2 | 0.841 |
WNK1 |
0.737 | 0.175 | -2 | 0.888 |
MST4 |
0.737 | 0.156 | 2 | 0.198 |
DMPK1 |
0.737 | 0.465 | -3 | 0.614 |
MARK2 |
0.737 | 0.231 | 4 | 0.863 |
DYRK1B |
0.737 | 0.275 | 1 | 0.586 |
AURA |
0.736 | 0.223 | -2 | 0.711 |
NIK |
0.736 | 0.354 | -3 | 0.331 |
PKCB |
0.735 | 0.218 | 2 | 0.104 |
PKCA |
0.735 | 0.181 | 2 | 0.119 |
NLK |
0.735 | 0.116 | 1 | 0.762 |
RAF1 |
0.734 | 0.187 | 1 | 0.819 |
PKCT |
0.733 | 0.277 | 2 | 0.100 |
PKCE |
0.733 | 0.303 | 2 | 0.109 |
PKCG |
0.733 | 0.193 | 2 | 0.107 |
ROCK1 |
0.733 | 0.452 | -3 | 0.605 |
DAPK1 |
0.733 | 0.433 | -3 | 0.604 |
SSTK |
0.733 | 0.199 | 4 | 0.898 |
PKCH |
0.732 | 0.218 | 2 | 0.089 |
MOS |
0.732 | 0.113 | 1 | 0.801 |
LATS1 |
0.731 | 0.289 | -3 | 0.404 |
DYRK4 |
0.730 | 0.206 | 1 | 0.571 |
WNK3 |
0.727 | 0.073 | 1 | 0.778 |
ERK5 |
0.727 | 0.042 | 1 | 0.783 |
TBK1 |
0.726 | 0.016 | 1 | 0.762 |
TGFBR2 |
0.726 | 0.071 | -2 | 0.772 |
COT |
0.725 | -0.071 | 2 | 0.128 |
ATR |
0.725 | 0.076 | 1 | 0.763 |
MTOR |
0.725 | 0.023 | 1 | 0.754 |
IKKB |
0.725 | 0.059 | -2 | 0.743 |
PRPK |
0.724 | -0.045 | -1 | 0.841 |
CHAK2 |
0.724 | 0.134 | -1 | 0.865 |
RIPK1 |
0.724 | 0.122 | 1 | 0.740 |
PKCI |
0.724 | 0.215 | 2 | 0.117 |
CDK7 |
0.723 | 0.092 | 1 | 0.610 |
RIPK3 |
0.723 | 0.025 | 3 | 0.784 |
PKCZ |
0.722 | 0.162 | 2 | 0.133 |
IKKE |
0.722 | 0.013 | 1 | 0.773 |
PDHK4 |
0.722 | -0.092 | 1 | 0.813 |
PDHK1 |
0.722 | -0.032 | 1 | 0.824 |
HUNK |
0.721 | -0.026 | 2 | 0.110 |
BCKDK |
0.720 | -0.011 | -1 | 0.819 |
GCN2 |
0.720 | -0.121 | 2 | 0.140 |
CAMK2G |
0.718 | -0.064 | 2 | 0.151 |
KIS |
0.718 | 0.049 | 1 | 0.636 |
ULK2 |
0.717 | -0.136 | 2 | 0.127 |
MASTL |
0.716 | -0.003 | -2 | 0.810 |
BMPR2 |
0.716 | -0.092 | -2 | 0.861 |
CDK10 |
0.715 | 0.143 | 1 | 0.557 |
BUB1 |
0.714 | 0.233 | -5 | 0.877 |
IRE1 |
0.713 | 0.001 | 1 | 0.716 |
TTBK2 |
0.713 | -0.077 | 2 | 0.093 |
WNK4 |
0.712 | 0.145 | -2 | 0.862 |
CHAK1 |
0.711 | 0.073 | 2 | 0.225 |
CDK14 |
0.711 | 0.106 | 1 | 0.575 |
PASK |
0.711 | 0.293 | -3 | 0.449 |
ATM |
0.711 | 0.033 | 1 | 0.714 |
NEK2 |
0.711 | -0.024 | 2 | 0.168 |
FAM20C |
0.710 | -0.052 | 2 | 0.082 |
NEK7 |
0.709 | -0.126 | -3 | 0.140 |
DSTYK |
0.708 | -0.149 | 2 | 0.144 |
ANKRD3 |
0.708 | -0.005 | 1 | 0.798 |
IRE2 |
0.708 | -0.019 | 2 | 0.106 |
MLK2 |
0.708 | -0.074 | 2 | 0.158 |
GRK1 |
0.708 | -0.019 | -2 | 0.859 |
DLK |
0.708 | 0.039 | 1 | 0.766 |
NEK6 |
0.707 | -0.092 | -2 | 0.796 |
DNAPK |
0.707 | 0.039 | 1 | 0.723 |
ULK1 |
0.707 | -0.178 | -3 | 0.117 |
NEK9 |
0.707 | -0.113 | 2 | 0.146 |
MLK1 |
0.706 | -0.126 | 2 | 0.115 |
CK1E |
0.706 | -0.059 | -3 | 0.088 |
GRK5 |
0.706 | -0.109 | -3 | 0.162 |
SMG1 |
0.704 | 0.015 | 1 | 0.724 |
CDK8 |
0.704 | -0.018 | 1 | 0.604 |
PKR |
0.704 | 0.028 | 1 | 0.768 |
IKKA |
0.704 | -0.050 | -2 | 0.722 |
CDK18 |
0.704 | 0.029 | 1 | 0.534 |
GRK6 |
0.703 | -0.052 | 1 | 0.762 |
CDK19 |
0.703 | -0.005 | 1 | 0.569 |
CK1D |
0.703 | -0.042 | -3 | 0.068 |
MEK1 |
0.703 | -0.014 | 2 | 0.170 |
CK1A2 |
0.702 | -0.049 | -3 | 0.094 |
IRAK4 |
0.702 | 0.025 | 1 | 0.737 |
PLK4 |
0.702 | -0.062 | 2 | 0.075 |
ALK4 |
0.701 | -0.010 | -2 | 0.818 |
PDK1 |
0.700 | 0.258 | 1 | 0.749 |
P38A |
0.700 | 0.016 | 1 | 0.657 |
ERK7 |
0.699 | -0.029 | 2 | 0.078 |
MLK3 |
0.699 | -0.091 | 2 | 0.112 |
BMPR1B |
0.699 | 0.003 | 1 | 0.721 |
TTBK1 |
0.698 | -0.074 | 2 | 0.073 |
CK1G1 |
0.698 | -0.073 | -3 | 0.080 |
GRK4 |
0.698 | -0.127 | -2 | 0.837 |
MST3 |
0.698 | 0.063 | 2 | 0.166 |
DRAK1 |
0.698 | 0.037 | 1 | 0.658 |
TGFBR1 |
0.698 | -0.033 | -2 | 0.793 |
CDK9 |
0.697 | 0.015 | 1 | 0.596 |
VRK2 |
0.697 | -0.086 | 1 | 0.799 |
JNK2 |
0.697 | 0.009 | 1 | 0.567 |
MPSK1 |
0.697 | 0.040 | 1 | 0.686 |
LOK |
0.696 | 0.147 | -2 | 0.786 |
YSK4 |
0.696 | -0.067 | 1 | 0.763 |
PERK |
0.695 | -0.060 | -2 | 0.809 |
LKB1 |
0.695 | 0.089 | -3 | 0.157 |
PBK |
0.694 | 0.128 | 1 | 0.692 |
CDK12 |
0.694 | 0.019 | 1 | 0.565 |
CDK13 |
0.694 | -0.008 | 1 | 0.587 |
ERK2 |
0.693 | -0.016 | 1 | 0.617 |
P38B |
0.693 | 0.005 | 1 | 0.600 |
MEK5 |
0.693 | -0.015 | 2 | 0.149 |
ERK1 |
0.693 | -0.005 | 1 | 0.588 |
CDK17 |
0.692 | 0.003 | 1 | 0.483 |
BRAF |
0.692 | -0.003 | -4 | 0.789 |
PRP4 |
0.692 | -0.053 | -3 | 0.119 |
GRK7 |
0.692 | 0.022 | 1 | 0.689 |
ALK2 |
0.691 | -0.031 | -2 | 0.807 |
IRAK1 |
0.691 | -0.043 | -1 | 0.779 |
HPK1 |
0.691 | 0.161 | 1 | 0.785 |
HRI |
0.690 | -0.076 | -2 | 0.806 |
PLK1 |
0.690 | -0.106 | -2 | 0.750 |
TLK1 |
0.689 | -0.041 | -2 | 0.795 |
PINK1 |
0.689 | -0.046 | 1 | 0.724 |
MEKK6 |
0.689 | 0.041 | 1 | 0.780 |
YANK3 |
0.689 | 0.000 | 2 | 0.050 |
CDK5 |
0.689 | -0.022 | 1 | 0.617 |
MLK4 |
0.689 | -0.139 | 2 | 0.085 |
TAO3 |
0.689 | 0.067 | 1 | 0.753 |
MEKK1 |
0.688 | -0.096 | 1 | 0.769 |
JNK3 |
0.688 | -0.024 | 1 | 0.599 |
TLK2 |
0.688 | -0.066 | 1 | 0.755 |
NEK11 |
0.688 | -0.010 | 1 | 0.760 |
NEK5 |
0.687 | -0.072 | 1 | 0.771 |
ACVR2B |
0.687 | -0.040 | -2 | 0.762 |
KHS2 |
0.687 | 0.160 | 1 | 0.799 |
PLK3 |
0.686 | -0.128 | 2 | 0.115 |
ZAK |
0.686 | -0.097 | 1 | 0.745 |
KHS1 |
0.686 | 0.148 | 1 | 0.799 |
NEK4 |
0.686 | 0.020 | 1 | 0.771 |
ACVR2A |
0.686 | -0.060 | -2 | 0.751 |
TAO2 |
0.685 | 0.035 | 2 | 0.169 |
SLK |
0.685 | 0.081 | -2 | 0.735 |
MEKK2 |
0.685 | -0.087 | 2 | 0.125 |
GCK |
0.685 | 0.107 | 1 | 0.783 |
CDK16 |
0.684 | -0.000 | 1 | 0.499 |
CDK4 |
0.684 | 0.052 | 1 | 0.550 |
CAMKK2 |
0.684 | 0.006 | -2 | 0.759 |
GRK2 |
0.684 | -0.061 | -2 | 0.732 |
NEK8 |
0.684 | 0.006 | 2 | 0.136 |
P38G |
0.684 | -0.012 | 1 | 0.488 |
MAP3K15 |
0.684 | 0.008 | 1 | 0.740 |
BMPR1A |
0.683 | -0.017 | 1 | 0.704 |
MEKK3 |
0.682 | -0.118 | 1 | 0.758 |
LRRK2 |
0.682 | 0.099 | 2 | 0.161 |
RIPK2 |
0.681 | -0.005 | 1 | 0.711 |
STK33 |
0.681 | -0.040 | 2 | 0.090 |
CDK1 |
0.681 | -0.016 | 1 | 0.557 |
HGK |
0.681 | 0.043 | 3 | 0.820 |
TNIK |
0.680 | 0.066 | 3 | 0.817 |
MINK |
0.680 | 0.061 | 1 | 0.792 |
NEK1 |
0.679 | 0.004 | 1 | 0.753 |
TAK1 |
0.679 | 0.039 | 1 | 0.791 |
GAK |
0.679 | -0.003 | 1 | 0.743 |
NEK3 |
0.678 | -0.011 | 1 | 0.744 |
CAMKK1 |
0.676 | -0.103 | -2 | 0.753 |
YSK1 |
0.675 | 0.007 | 2 | 0.151 |
HASPIN |
0.675 | 0.073 | -1 | 0.713 |
P38D |
0.675 | -0.013 | 1 | 0.519 |
CDK2 |
0.675 | -0.066 | 1 | 0.625 |
GSK3B |
0.674 | -0.006 | 4 | 0.409 |
MST2 |
0.673 | -0.072 | 1 | 0.791 |
GRK3 |
0.673 | -0.066 | -2 | 0.698 |
MST1 |
0.672 | -0.019 | 1 | 0.779 |
CK1A |
0.672 | -0.061 | -3 | 0.044 |
MEK2 |
0.671 | -0.084 | 2 | 0.162 |
CDK6 |
0.670 | -0.010 | 1 | 0.561 |
VRK1 |
0.668 | -0.069 | 2 | 0.121 |
CDK3 |
0.668 | -0.019 | 1 | 0.503 |
EEF2K |
0.667 | -0.083 | 3 | 0.778 |
TAO1 |
0.666 | 0.048 | 1 | 0.717 |
PLK2 |
0.664 | -0.111 | -3 | 0.096 |
GSK3A |
0.664 | -0.021 | 4 | 0.415 |
JNK1 |
0.662 | -0.036 | 1 | 0.543 |
MYO3B |
0.662 | 0.019 | 2 | 0.190 |
TTK |
0.661 | -0.005 | -2 | 0.782 |
BIKE |
0.660 | 0.001 | 1 | 0.624 |
LIMK2_TYR |
0.659 | 0.198 | -3 | 0.239 |
PDHK3_TYR |
0.656 | 0.061 | 4 | 0.884 |
CK2A2 |
0.656 | -0.060 | 1 | 0.637 |
ASK1 |
0.655 | -0.059 | 1 | 0.726 |
TESK1_TYR |
0.654 | 0.099 | 3 | 0.877 |
TNK2 |
0.653 | 0.122 | 3 | 0.808 |
MYO3A |
0.653 | -0.005 | 1 | 0.756 |
PKMYT1_TYR |
0.651 | 0.070 | 3 | 0.867 |
CK1G3 |
0.651 | -0.075 | -3 | 0.041 |
OSR1 |
0.650 | -0.083 | 2 | 0.158 |
RET |
0.649 | 0.061 | 1 | 0.770 |
MAP2K4_TYR |
0.649 | 0.111 | -1 | 0.850 |
MAP2K7_TYR |
0.647 | -0.032 | 2 | 0.171 |
TNK1 |
0.647 | 0.098 | 3 | 0.810 |
NEK10_TYR |
0.646 | 0.146 | 1 | 0.679 |
AAK1 |
0.646 | 0.015 | 1 | 0.529 |
EPHA6 |
0.645 | -0.021 | -1 | 0.831 |
MST1R |
0.645 | 0.036 | 3 | 0.846 |
ROS1 |
0.645 | 0.032 | 3 | 0.804 |
CK2A1 |
0.645 | -0.072 | 1 | 0.615 |
PINK1_TYR |
0.644 | 0.071 | 1 | 0.759 |
LIMK1_TYR |
0.644 | 0.028 | 2 | 0.178 |
YANK2 |
0.643 | -0.059 | 2 | 0.048 |
DDR1 |
0.643 | 0.032 | 4 | 0.809 |
EPHB4 |
0.642 | -0.024 | -1 | 0.828 |
TYK2 |
0.642 | 0.002 | 1 | 0.782 |
TYRO3 |
0.642 | -0.042 | 3 | 0.819 |
ALPHAK3 |
0.642 | -0.058 | -1 | 0.733 |
PDHK4_TYR |
0.641 | -0.059 | 2 | 0.196 |
STLK3 |
0.641 | -0.108 | 1 | 0.719 |
JAK1 |
0.641 | 0.085 | 1 | 0.750 |
MAP2K6_TYR |
0.640 | -0.050 | -1 | 0.851 |
TNNI3K_TYR |
0.640 | 0.014 | 1 | 0.777 |
AXL |
0.639 | 0.010 | 3 | 0.825 |
JAK2 |
0.639 | -0.025 | 1 | 0.784 |
ABL2 |
0.639 | 0.013 | -1 | 0.812 |
PDHK1_TYR |
0.638 | -0.068 | -1 | 0.856 |
BMPR2_TYR |
0.637 | -0.060 | -1 | 0.830 |
PDGFRB |
0.636 | -0.015 | 3 | 0.838 |
ABL1 |
0.636 | -0.009 | -1 | 0.809 |
DDR2 |
0.636 | 0.089 | 3 | 0.783 |
TEK |
0.634 | -0.053 | 3 | 0.771 |
PDGFRA |
0.634 | -0.014 | 3 | 0.832 |
CSF1R |
0.634 | -0.063 | 3 | 0.830 |
LTK |
0.633 | 0.012 | 3 | 0.800 |
EPHB3 |
0.633 | -0.056 | -1 | 0.820 |
ALK |
0.633 | 0.023 | 3 | 0.774 |
EPHA4 |
0.633 | -0.079 | 2 | 0.134 |
EPHA1 |
0.633 | -0.008 | 3 | 0.815 |
JAK3 |
0.633 | -0.038 | 1 | 0.743 |
EPHB1 |
0.633 | -0.061 | 1 | 0.798 |
INSRR |
0.632 | -0.028 | 3 | 0.786 |
MERTK |
0.632 | -0.048 | 3 | 0.825 |
FGFR2 |
0.632 | -0.066 | 3 | 0.835 |
TXK |
0.631 | -0.040 | 1 | 0.755 |
FGFR1 |
0.631 | -0.060 | 3 | 0.817 |
LCK |
0.630 | 0.001 | -1 | 0.815 |
FLT3 |
0.630 | -0.035 | 3 | 0.816 |
FER |
0.630 | -0.088 | 1 | 0.804 |
EPHB2 |
0.629 | -0.074 | -1 | 0.807 |
KDR |
0.629 | -0.032 | 3 | 0.804 |
SRMS |
0.629 | -0.091 | 1 | 0.788 |
FGR |
0.629 | -0.074 | 1 | 0.771 |
EPHA7 |
0.629 | -0.056 | 2 | 0.126 |
ITK |
0.628 | -0.069 | -1 | 0.809 |
YES1 |
0.627 | -0.079 | -1 | 0.840 |
HCK |
0.626 | -0.068 | -1 | 0.819 |
BLK |
0.626 | -0.008 | -1 | 0.813 |
EPHA3 |
0.625 | -0.084 | 2 | 0.121 |
BTK |
0.625 | -0.088 | -1 | 0.806 |
PTK2B |
0.624 | -0.039 | -1 | 0.795 |
TEC |
0.623 | -0.052 | -1 | 0.767 |
PTK6 |
0.622 | -0.053 | -1 | 0.747 |
KIT |
0.622 | -0.093 | 3 | 0.831 |
BMX |
0.621 | -0.048 | -1 | 0.733 |
MET |
0.621 | -0.058 | 3 | 0.828 |
NTRK1 |
0.619 | -0.106 | -1 | 0.811 |
EPHA5 |
0.618 | -0.083 | 2 | 0.115 |
WEE1_TYR |
0.618 | -0.061 | -1 | 0.765 |
FRK |
0.618 | -0.083 | -1 | 0.836 |
NTRK2 |
0.618 | -0.093 | 3 | 0.797 |
FGFR3 |
0.617 | -0.103 | 3 | 0.808 |
INSR |
0.617 | -0.081 | 3 | 0.759 |
CK1G2 |
0.616 | -0.079 | -3 | 0.057 |
ERBB2 |
0.616 | -0.104 | 1 | 0.715 |
FLT4 |
0.616 | -0.099 | 3 | 0.793 |
EPHA8 |
0.614 | -0.079 | -1 | 0.784 |
NTRK3 |
0.612 | -0.087 | -1 | 0.764 |
MATK |
0.611 | -0.081 | -1 | 0.734 |
LYN |
0.611 | -0.091 | 3 | 0.760 |
FLT1 |
0.610 | -0.121 | -1 | 0.788 |
FYN |
0.610 | -0.086 | -1 | 0.780 |
CSK |
0.608 | -0.101 | 2 | 0.126 |
PTK2 |
0.605 | -0.071 | -1 | 0.730 |
MUSK |
0.603 | -0.080 | 1 | 0.612 |
EPHA2 |
0.603 | -0.101 | -1 | 0.747 |
EGFR |
0.601 | -0.111 | 1 | 0.621 |
SRC |
0.601 | -0.108 | -1 | 0.783 |
FGFR4 |
0.601 | -0.108 | -1 | 0.741 |
IGF1R |
0.598 | -0.101 | 3 | 0.707 |
SYK |
0.593 | -0.095 | -1 | 0.715 |
ERBB4 |
0.592 | -0.092 | 1 | 0.633 |
FES |
0.591 | -0.102 | -1 | 0.708 |
ZAP70 |
0.576 | -0.067 | -1 | 0.652 |