Motif 34 (n=118)

Position-wise Probabilities

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uniprot genes site source protein function
A0A1B0GUH1 None S413 ochoa Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000256|ARBA:ARBA00003631, ECO:0000256|RuleBase:RU003981}.
I3L0D1 RBAK-RBAKDN S78 ochoa HCG1647537, isoform CRA_b (RBAK-RBAKDN readthrough) None
M0QX08 None S58 ochoa Protein kinase domain-containing protein None
O00562 PITPNM1 S896 ochoa|psp Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}.
O14744 PRMT5 S310 ochoa Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}.
O15375 SLC16A5 S451 ochoa Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5) Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.
O75420 GIGYF1 S148 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O94913 PCF11 S705 ochoa Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}.
O95271 TNKS S218 ochoa Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}.
O95279 KCNK5 S385 ochoa Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}.
O95359 TACC2 S758 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
O95602 POLR1A S1695 ochoa DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity) (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). {ECO:0000250|UniProtKB:P10964, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.
O95936 EOMES S596 ochoa Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}.
P00352 ALDH1A1 S75 ochoa Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}.
P09874 PARP1 S537 ochoa Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}.
P10275 AR S651 ochoa|psp Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.
P15104 GLUL S322 psp Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:16267323, PubMed:30158707, PubMed:36289327). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351). Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (PubMed:36289327). {ECO:0000250|UniProtKB:P15105, ECO:0000269|PubMed:16267323, ECO:0000269|PubMed:18662667, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:30158707, ECO:0000269|PubMed:36289327}.
P18583 SON S1556 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P18754 RCC1 S387 psp Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}.
P24723 PRKCH S317 ochoa Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}.
P29317 EPHA2 S277 psp Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}.
P33241 LSP1 S111 ochoa Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}.
P48681 NES S680 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P48728 AMT S334 ochoa Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT) The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000269|PubMed:16051266}.
P53634 CTSC S329 ochoa Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). {ECO:0000269|PubMed:1586157, ECO:0000269|PubMed:8428921}.
P53667 LIMK1 S210 ochoa LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}.
P53814 SMTN S729 ochoa Smoothelin Structural protein of the cytoskeleton.
P55327 TPD52 S40 psp Tumor protein D52 (Protein N8) None
P62750 RPL23A S43 ochoa Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}.
Q02078 MEF2A S255 ochoa|psp Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.
Q05639 EEF1A2 S358 psp Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}.
Q08499 PDE4D S255 ochoa 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}.
Q09666 AHNAK S5552 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q13237 PRKG2 S97 ochoa cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}.
Q14153 FAM53B S212 ochoa Protein FAM53B (Protein simplet) Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}.
Q14160 SCRIB S1140 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14203 DCTN1 S105 ochoa Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}.
Q14324 MYBPC2 S884 ochoa Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Q15149 PLEC S2958 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15772 SPEG S2448 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q1MSJ5 CSPP1 S459 ochoa Centrosome and spindle pole-associated protein 1 May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}.
Q53EU6 GPAT3 S77 ochoa Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10) (AGPAT 10) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Acyl-CoA:glycerol-3-phosphate acyltransferase 3) (hGPAT3) (Lung cancer metastasis-associated protein 1) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta) (MAG-1) Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:17170135, ECO:0000269|PubMed:19318427, ECO:0000269|PubMed:30846318}.
Q58EX7 PLEKHG4 S716 ochoa Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.
Q5JPE7 NOMO2 S1205 ochoa BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2) Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.
Q5JTV8 TOR1AIP1 S143 ochoa|psp Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}.
Q5JTW2 CEP78 S654 ochoa Centrosomal protein of 78 kDa (Cep78) Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:27246242, PubMed:27588451, PubMed:28242748, PubMed:34259627). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). Involved in cilium biogenesis and controls cilium length (PubMed:27588451). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:28242748, PubMed:34259627). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity). {ECO:0000250|UniProtKB:Q6IRU7, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.
Q5T8D3 ACBD5 S404 ochoa Acyl-CoA-binding domain-containing protein 5 Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}.
Q5TCZ1 SH3PXD2A S644 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5VWQ0 RSBN1 S547 ochoa Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}.
Q659C4 LARP1B S633 ochoa La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) None
Q684P5 RAP1GAP2 S668 ochoa Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}.
Q69YU3 ANKRD34A S461 ochoa Ankyrin repeat domain-containing protein 34A None
Q6P435 None S111 ochoa Putative uncharacterized SMG1-like protein None
Q6PCB5 RSBN1L S536 ochoa Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}.
Q6PIF6 MYO7B S934 ochoa Unconventional myosin-VIIb Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length (PubMed:24725409, PubMed:26812018, PubMed:32209652). May link the complex to the actin core bundle of microvilli. {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018, ECO:0000269|PubMed:32209652, ECO:0000305|PubMed:24725409, ECO:0000305|PubMed:26812018}.
Q6UB35 MTHFD1L S62 ochoa Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.
Q702N8 XIRP1 S481 ochoa Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}.
Q709C8 VPS13C S1894 ochoa Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}.
Q7L8C5 SYT13 S113 ochoa Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII) May be involved in transport vesicle docking to the plasma membrane. {ECO:0000250}.
Q7Z4K8 TRIM46 S627 ochoa Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein) Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. {ECO:0000250|UniProtKB:Q7TNM2}.
Q86W92 PPFIBP1 S37 ochoa Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.
Q86XL3 ANKLE2 S804 ochoa Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}.
Q8IWU2 LMTK2 S1397 ochoa Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) Phosphorylates PPP1C, phosphorylase b and CFTR.
Q8IYK8 REM2 S295 ochoa GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}.
Q8IZT6 ASPM S425 ochoa Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}.
Q8N137 CNTROB S790 ochoa Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}.
Q8NCD3 HJURP S642 ochoa|psp Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}.
Q8NFC6 BOD1L1 S2501 ochoa Biorientation of chromosomes in cell division protein 1-like 1 Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}.
Q8TF30 WHAMM S181 ochoa WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1) Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}.
Q8TF72 SHROOM3 S1662 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8WUA4 GTF3C2 S25 ochoa General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.
Q8WUY3 PRUNE2 S576 ochoa Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
Q8WXH2 JPH3 S457 ochoa Junctophilin-3 (JP-3) (Junctophilin type 3) (Trinucleotide repeat-containing gene 22 protein) Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
Q92613 JADE3 S695 ochoa Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}.
Q93084 ATP2A3 S662 ochoa Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
Q96F46 IL17RA S708 ochoa|psp Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}.
Q96I15 SCLY S129 ochoa Selenocysteine lyase (hSCL) (EC 4.4.1.16) Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. {ECO:0000250|UniProtKB:Q68FT9}.
Q96JA1 LRIG1 S975 ochoa Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.
Q96JZ2 HSH2D S276 ochoa Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}.
Q96PE2 ARHGEF17 S332 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96PE2 ARHGEF17 S619 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96Q15 SMG1 S115 ochoa Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}.
Q96QT4 TRPM7 S1543 ochoa|psp Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}.
Q99707 MTR S156 ochoa Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase) Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:16769880, PubMed:17288554, PubMed:27771510). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed:16769880, PubMed:17288554, PubMed:27771510). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:16769880, PubMed:27771510). {ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17288554, ECO:0000269|PubMed:27771510}.
Q9BR39 JPH2 S157 ochoa Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}.
Q9BRS8 LARP6 S384 ochoa La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}.
Q9BRS8 LARP6 S409 ochoa|psp La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}.
Q9BW04 SARG S519 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BY89 KIAA1671 S558 ochoa Uncharacterized protein KIAA1671 None
Q9BY89 KIAA1671 S1224 ochoa Uncharacterized protein KIAA1671 None
Q9BZ71 PITPNM3 S612 ochoa Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}.
Q9C073 FAM117A S207 ochoa Protein FAM117A (C/EBP-induced protein) None
Q9H9B1 EHMT1 S1004 ochoa Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.
Q9HAN9 NMNAT1 S117 ochoa Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity (By similarity). {ECO:0000250|UniProtKB:Q9EPA7, ECO:0000269|PubMed:17402747, ECO:0000269|PubMed:27257257}.
Q9NWQ8 PAG1 S288 ochoa Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.
Q9NYW8 RBAK S78 ochoa RB-associated KRAB zinc finger protein (RB-associated KRAB repressor) (hRBaK) (Zinc finger protein 769) May repress E2F-dependent transcription. May promote AR-dependent transcription. {ECO:0000269|PubMed:10702291, ECO:0000269|PubMed:14664718}.
Q9UBU6 FAM8A1 S229 ochoa Protein FAM8A1 (Autosomal highly conserved protein) Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}.
Q9UDY2 TJP2 S130 ochoa Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}.
Q9UDY4 DNAJB4 S148 ochoa DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}.
Q9UF56 FBXL17 S303 ochoa F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9QZN1, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:30190310}.
Q9UKS6 PACSIN3 S341 ochoa Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}.
Q9UNS1 TIMELESS S1087 ochoa Protein timeless homolog (hTIM) Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}.
Q9UPP1 PHF8 S120 ochoa|psp Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}.
Q9UPQ0 LIMCH1 S601 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UPQ9 TNRC6B S803 ochoa Trinucleotide repeat-containing gene 6B protein Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.
Q9Y2H9 MAST1 S1413 ochoa Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}.
Q9Y2I6 NINL S191 ochoa Ninein-like protein Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.
Q9Y2U8 LEMD3 S402 ochoa|psp Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y2W1 THRAP3 S560 ochoa Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.
Q9Y4Z2 NEUROG3 S174 psp Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5) Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}.
P62714 PPP2CB Y80 Sugiyama Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}.
P67775 PPP2CA Y80 Sugiyama Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}.
O15264 MAPK13 S27 Sugiyama Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212, ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148, ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666, ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}.
P17813 ENG S521 Sugiyama Endoglin (CD antigen CD105) Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484, ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}.
Q15751 HERC1 S3238 Sugiyama Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.
P16298 PPP3CB Y122 Sugiyama Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity). {ECO:0000250|UniProtKB:P48453, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:32753672}.
P48454 PPP3CC Y109 Sugiyama Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. {ECO:0000269|PubMed:19154138}.
Q08209 PPP3CA Y113 Sugiyama Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}.
Download
reactome_id name p -log10_p
R-HSA-180024 DARPP-32 events 4.153689e-07 6.382
R-HSA-68886 M Phase 8.383300e-05 4.077
R-HSA-111885 Opioid Signalling 3.145834e-04 3.502
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 1.315385e-03 2.881
R-HSA-198753 ERK/MAPK targets 1.181265e-03 2.928
R-HSA-69275 G2/M Transition 1.225028e-03 2.912
R-HSA-453274 Mitotic G2-G2/M phases 1.294548e-03 2.888
R-HSA-68875 Mitotic Prophase 6.983450e-04 3.156
R-HSA-69278 Cell Cycle, Mitotic 7.331632e-04 3.135
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 2.467783e-03 2.608
R-HSA-380259 Loss of Nlp from mitotic centrosomes 2.467783e-03 2.608
R-HSA-8854518 AURKA Activation by TPX2 2.860402e-03 2.544
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 2.738247e-03 2.563
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 2.885417e-03 2.540
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 5.541290e-03 2.256
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 5.541290e-03 2.256
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 5.541290e-03 2.256
R-HSA-5339716 Signaling by GSK3beta mutants 6.328885e-03 2.199
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 7.164336e-03 2.145
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 7.164336e-03 2.145
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 7.164336e-03 2.145
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 7.164336e-03 2.145
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 7.164336e-03 2.145
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 3.938432e-03 2.405
R-HSA-380287 Centrosome maturation 4.290668e-03 2.367
R-HSA-2025928 Calcineurin activates NFAT 4.112837e-03 2.386
R-HSA-4791275 Signaling by WNT in cancer 3.445472e-03 2.463
R-HSA-4839744 Signaling by APC mutants 5.541290e-03 2.256
R-HSA-202670 ERKs are inactivated 6.328885e-03 2.199
R-HSA-4839735 Signaling by AXIN mutants 6.328885e-03 2.199
R-HSA-4839748 Signaling by AMER1 mutants 6.328885e-03 2.199
R-HSA-1483226 Synthesis of PI 5.541290e-03 2.256
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 6.328885e-03 2.199
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 6.139405e-03 2.212
R-HSA-68877 Mitotic Prometaphase 6.709804e-03 2.173
R-HSA-2465910 MASTL Facilitates Mitotic Progression 4.112837e-03 2.386
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 5.262926e-03 2.279
R-HSA-4086398 Ca2+ pathway 3.938432e-03 2.405
R-HSA-195721 Signaling by WNT 3.706498e-03 2.431
R-HSA-448424 Interleukin-17 signaling 3.447644e-03 2.462
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.703708e-03 2.431
R-HSA-1640170 Cell Cycle 4.826212e-03 2.316
R-HSA-3858494 Beta-catenin independent WNT signaling 7.329781e-03 2.135
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 7.365022e-03 2.133
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 7.897274e-03 2.103
R-HSA-196299 Beta-catenin phosphorylation cascade 9.950047e-03 2.002
R-HSA-1295596 Spry regulation of FGF signaling 9.950047e-03 2.002
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 8.975685e-03 2.047
R-HSA-2299718 Condensation of Prophase Chromosomes 9.034516e-03 2.044
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 1.096919e-02 1.960
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 1.096919e-02 1.960
R-HSA-68882 Mitotic Anaphase 1.099302e-02 1.959
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.120545e-02 1.951
R-HSA-927802 Nonsense-Mediated Decay (NMD) 1.676704e-02 1.776
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.676704e-02 1.776
R-HSA-9754189 Germ layer formation at gastrulation 1.547881e-02 1.810
R-HSA-389513 Co-inhibition by CTLA4 1.671085e-02 1.777
R-HSA-6804760 Regulation of TP53 Activity through Methylation 1.428791e-02 1.845
R-HSA-113510 E2F mediated regulation of DNA replication 1.547881e-02 1.810
R-HSA-418346 Platelet homeostasis 1.424494e-02 1.846
R-HSA-432142 Platelet sensitization by LDL 1.428791e-02 1.845
R-HSA-450294 MAP kinase activation 1.732827e-02 1.761
R-HSA-5545619 XAV939 stabilizes AXIN 2.320265e-02 1.634
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.346386e-02 1.630
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.796561e-02 1.553
R-HSA-525793 Myogenesis 2.642907e-02 1.578
R-HSA-162582 Signal Transduction 2.813837e-02 1.551
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 2.539989e-02 1.595
R-HSA-187037 Signaling by NTRK1 (TRKA) 2.652307e-02 1.576
R-HSA-5654732 Negative regulation of FGFR3 signaling 2.953726e-02 1.530
R-HSA-5654733 Negative regulation of FGFR4 signaling 3.114338e-02 1.507
R-HSA-111465 Apoptotic cleavage of cellular proteins 3.616239e-02 1.442
R-HSA-5654726 Negative regulation of FGFR1 signaling 3.790024e-02 1.421
R-HSA-141424 Amplification of signal from the kinetochores 3.812394e-02 1.419
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 3.812394e-02 1.419
R-HSA-8941237 Invadopodia formation 3.837356e-02 1.416
R-HSA-5654727 Negative regulation of FGFR2 signaling 4.146966e-02 1.382
R-HSA-5673000 RAF activation 4.146966e-02 1.382
R-HSA-166520 Signaling by NTRKs 4.210613e-02 1.376
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 4.330005e-02 1.364
R-HSA-6804757 Regulation of TP53 Degradation 4.516013e-02 1.345
R-HSA-3359467 Defective MTRR causes HMAE 6.069270e-02 1.217
R-HSA-426496 Post-transcriptional silencing by small RNAs 5.331068e-02 1.273
R-HSA-69618 Mitotic Spindle Checkpoint 5.715548e-02 1.243
R-HSA-156842 Eukaryotic Translation Elongation 4.660309e-02 1.332
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 6.069270e-02 1.217
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 5.091288e-02 1.293
R-HSA-8853884 Transcriptional Regulation by VENTX 5.488631e-02 1.261
R-HSA-5654743 Signaling by FGFR4 6.104314e-02 1.214
R-HSA-5675221 Negative regulation of MAPK pathway 5.691289e-02 1.245
R-HSA-6806003 Regulation of TP53 Expression and Degradation 5.091288e-02 1.293
R-HSA-5633007 Regulation of TP53 Activity 5.191460e-02 1.285
R-HSA-975871 MyD88 cascade initiated on plasma membrane 5.471985e-02 1.262
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 5.471985e-02 1.262
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 5.471985e-02 1.262
R-HSA-69236 G1 Phase 6.314578e-02 1.200
R-HSA-69231 Cyclin D associated events in G1 6.314578e-02 1.200
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 6.476505e-02 1.189
R-HSA-5654741 Signaling by FGFR3 6.527275e-02 1.185
R-HSA-75153 Apoptotic execution phase 6.742356e-02 1.171
R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 6.801760e-02 1.167
R-HSA-3359469 Defective MTR causes HMAG 6.801760e-02 1.167
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 6.873649e-02 1.163
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 6.873649e-02 1.163
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 7.008449e-02 1.154
R-HSA-975155 MyD88 dependent cascade initiated on endosome 7.008449e-02 1.154
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 7.144445e-02 1.146
R-HSA-166166 MyD88-independent TLR4 cascade 7.144445e-02 1.146
R-HSA-389356 Co-stimulation by CD28 7.179470e-02 1.144
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 7.528583e-02 1.123
R-HSA-446107 Type I hemidesmosome assembly 8.249783e-02 1.084
R-HSA-9768778 Regulation of NPAS4 mRNA translation 8.249783e-02 1.084
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 1.038007e-01 0.984
R-HSA-73856 RNA Polymerase II Transcription Termination 1.022240e-01 0.990
R-HSA-191859 snRNP Assembly 9.733632e-02 1.012
R-HSA-194441 Metabolism of non-coding RNA 9.733632e-02 1.012
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 8.249783e-02 1.084
R-HSA-192814 vRNA Synthesis 1.038007e-01 0.984
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 1.107920e-01 0.955
R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 8.249783e-02 1.084
R-HSA-112313 Neurotransmitter uptake and metabolism In glial cells 8.249783e-02 1.084
R-HSA-418359 Reduction of cytosolic Ca++ levels 1.107920e-01 0.955
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 9.017446e-02 1.045
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 7.528583e-02 1.123
R-HSA-186712 Regulation of beta-cell development 9.733632e-02 1.012
R-HSA-5617833 Cilium Assembly 8.248976e-02 1.084
R-HSA-5654736 Signaling by FGFR1 9.013677e-02 1.045
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 7.528583e-02 1.123
R-HSA-9010642 ROBO receptors bind AKAP5 8.249783e-02 1.084
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 8.249783e-02 1.084
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 8.965402e-02 1.047
R-HSA-376176 Signaling by ROBO receptors 9.745847e-02 1.011
R-HSA-1483206 Glycerophospholipid biosynthesis 9.745847e-02 1.011
R-HSA-177929 Signaling by EGFR 9.013677e-02 1.045
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 8.716968e-02 1.060
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 8.716968e-02 1.060
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 9.169303e-02 1.038
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 9.169303e-02 1.038
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 7.559527e-02 1.122
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 7.985077e-02 1.098
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 1.382204e-01 0.859
R-HSA-9909620 Regulation of PD-L1(CD274) translation 1.777968e-01 0.750
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 1.905840e-01 0.720
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 1.905840e-01 0.720
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 1.905840e-01 0.720
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 1.969034e-01 0.706
R-HSA-8943723 Regulation of PTEN mRNA translation 2.031739e-01 0.692
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 1.846739e-01 0.734
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.874825e-01 0.727
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 1.987745e-01 0.702
R-HSA-192823 Viral mRNA Translation 2.244523e-01 0.649
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 1.969034e-01 0.706
R-HSA-156902 Peptide chain elongation 1.762873e-01 0.754
R-HSA-418457 cGMP effects 1.314430e-01 0.881
R-HSA-73863 RNA Polymerase I Transcription Termination 2.277737e-01 0.642
R-HSA-3928663 EPHA-mediated growth cone collapse 2.277737e-01 0.642
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 2.016107e-01 0.695
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 1.314430e-01 0.881
R-HSA-399954 Sema3A PAK dependent Axon repulsion 1.382204e-01 0.859
R-HSA-9823730 Formation of definitive endoderm 1.777968e-01 0.750
R-HSA-77595 Processing of Intronless Pre-mRNAs 1.516181e-01 0.819
R-HSA-72764 Eukaryotic Translation Termination 2.016107e-01 0.695
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 2.216953e-01 0.654
R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.249965e-01 0.903
R-HSA-9603798 Class I peroxisomal membrane protein import 1.449453e-01 0.839
R-HSA-5576886 Phase 4 - resting membrane potential 1.449453e-01 0.839
R-HSA-9839394 TGFBR3 expression 2.155695e-01 0.666
R-HSA-72689 Formation of a pool of free 40S subunits 2.016107e-01 0.695
R-HSA-392517 Rap1 signalling 1.713283e-01 0.766
R-HSA-9620244 Long-term potentiation 2.155695e-01 0.666
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 1.246128e-01 0.904
R-HSA-9708530 Regulation of BACH1 activity 1.449453e-01 0.839
R-HSA-9759218 Cobalamin (Cbl) metabolism 2.277737e-01 0.642
R-HSA-6783984 Glycine degradation 1.516181e-01 0.819
R-HSA-6807004 Negative regulation of MET activity 1.777968e-01 0.750
R-HSA-1257604 PIP3 activates AKT signaling 2.337821e-01 0.631
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 2.277737e-01 0.642
R-HSA-2682334 EPH-Ephrin signaling 1.902971e-01 0.721
R-HSA-2408557 Selenocysteine synthesis 2.187199e-01 0.660
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 2.216953e-01 0.654
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 1.905840e-01 0.720
R-HSA-429947 Deadenylation of mRNA 2.093958e-01 0.679
R-HSA-1482801 Acyl chain remodelling of PS 2.155695e-01 0.666
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 2.273230e-01 0.643
R-HSA-2467813 Separation of Sister Chromatids 1.715470e-01 0.766
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.198341e-01 0.921
R-HSA-3296469 Defects in cobalamin (B12) metabolism 2.155695e-01 0.666
R-HSA-168273 Influenza Viral RNA Transcription and Replication 1.545869e-01 0.811
R-HSA-111447 Activation of BAD and translocation to mitochondria 1.382204e-01 0.859
R-HSA-171007 p38MAPK events 1.382204e-01 0.859
R-HSA-70350 Fructose catabolism 1.449453e-01 0.839
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 1.842153e-01 0.735
R-HSA-3247509 Chromatin modifying enzymes 1.391673e-01 0.856
R-HSA-9768759 Regulation of NPAS4 gene expression 1.582393e-01 0.801
R-HSA-3214842 HDMs demethylate histones 2.155695e-01 0.666
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 1.449453e-01 0.839
R-HSA-4419969 Depolymerization of the Nuclear Lamina 1.648092e-01 0.783
R-HSA-4839726 Chromatin organization 1.608310e-01 0.794
R-HSA-5654738 Signaling by FGFR2 1.515440e-01 0.819
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 1.777968e-01 0.750
R-HSA-5652084 Fructose metabolism 1.969034e-01 0.706
R-HSA-3295583 TRP channels 2.216953e-01 0.654
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 1.249965e-01 0.903
R-HSA-1912420 Pre-NOTCH Processing in Golgi 1.713283e-01 0.766
R-HSA-71384 Ethanol oxidation 1.969034e-01 0.706
R-HSA-9860931 Response of endothelial cells to shear stress 2.273230e-01 0.643
R-HSA-201681 TCF dependent signaling in response to WNT 2.109468e-01 0.676
R-HSA-2028269 Signaling by Hippo 1.582393e-01 0.801
R-HSA-167044 Signalling to RAS 1.842153e-01 0.735
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.216953e-01 0.654
R-HSA-180292 GAB1 signalosome 1.648092e-01 0.783
R-HSA-2408522 Selenoamino acid metabolism 1.715470e-01 0.766
R-HSA-400685 Sema4D in semaphorin signaling 2.155695e-01 0.666
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 1.969034e-01 0.706
R-HSA-5607764 CLEC7A (Dectin-1) signaling 2.044517e-01 0.689
R-HSA-5673001 RAF/MAP kinase cascade 2.238103e-01 0.650
R-HSA-5683057 MAPK family signaling cascades 1.615447e-01 0.792
R-HSA-418594 G alpha (i) signalling events 1.203246e-01 0.920
R-HSA-9827857 Specification of primordial germ cells 1.582393e-01 0.801
R-HSA-168255 Influenza Infection 2.029033e-01 0.693
R-HSA-190236 Signaling by FGFR 2.101471e-01 0.677
R-HSA-70171 Glycolysis 2.158586e-01 0.666
R-HSA-1483257 Phospholipid metabolism 2.337821e-01 0.631
R-HSA-3700989 Transcriptional Regulation by TP53 1.821106e-01 0.740
R-HSA-9833482 PKR-mediated signaling 1.515440e-01 0.819
R-HSA-381038 XBP1(S) activates chaperone genes 1.707314e-01 0.768
R-HSA-109581 Apoptosis 1.677319e-01 0.775
R-HSA-381070 IRE1alpha activates chaperones 1.874825e-01 0.727
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 1.417907e-01 0.848
R-HSA-168898 Toll-like Receptor Cascades 2.272382e-01 0.644
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 2.338050e-01 0.631
R-HSA-5684996 MAPK1/MAPK3 signaling 2.354548e-01 0.628
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 2.388306e-01 0.622
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.388306e-01 0.622
R-HSA-9700206 Signaling by ALK in cancer 2.388306e-01 0.622
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 2.397896e-01 0.620
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 2.397896e-01 0.620
R-HSA-9759475 Regulation of CDH11 Expression and Function 2.397896e-01 0.620
R-HSA-418360 Platelet calcium homeostasis 2.397896e-01 0.620
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.417127e-01 0.617
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 2.417127e-01 0.617
R-HSA-76046 RNA Polymerase III Transcription Initiation 2.457278e-01 0.610
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 2.457278e-01 0.610
R-HSA-114452 Activation of BH3-only proteins 2.457278e-01 0.610
R-HSA-5694530 Cargo concentration in the ER 2.516200e-01 0.599
R-HSA-1912422 Pre-NOTCH Expression and Processing 2.561440e-01 0.592
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 2.574665e-01 0.589
R-HSA-5357801 Programmed Cell Death 2.583818e-01 0.588
R-HSA-9855142 Cellular responses to mechanical stimuli 2.590331e-01 0.587
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 2.632677e-01 0.580
R-HSA-9022692 Regulation of MECP2 expression and activity 2.632677e-01 0.580
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 2.632677e-01 0.580
R-HSA-9733709 Cardiogenesis 2.632677e-01 0.580
R-HSA-2871809 FCERI mediated Ca+2 mobilization 2.677027e-01 0.572
R-HSA-390522 Striated Muscle Contraction 2.690239e-01 0.570
R-HSA-5696394 DNA Damage Recognition in GG-NER 2.690239e-01 0.570
R-HSA-1482788 Acyl chain remodelling of PC 2.690239e-01 0.570
R-HSA-114508 Effects of PIP2 hydrolysis 2.690239e-01 0.570
R-HSA-8964539 Glutamate and glutamine metabolism 2.690239e-01 0.570
R-HSA-72613 Eukaryotic Translation Initiation 2.705927e-01 0.568
R-HSA-72737 Cap-dependent Translation Initiation 2.705927e-01 0.568
R-HSA-397014 Muscle contraction 2.731172e-01 0.564
R-HSA-70326 Glucose metabolism 2.734825e-01 0.563
R-HSA-5696400 Dual Incision in GG-NER 2.747355e-01 0.561
R-HSA-180746 Nuclear import of Rev protein 2.747355e-01 0.561
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 2.747355e-01 0.561
R-HSA-5365859 RA biosynthesis pathway 2.747355e-01 0.561
R-HSA-168638 NOD1/2 Signaling Pathway 2.747355e-01 0.561
R-HSA-1266738 Developmental Biology 2.761104e-01 0.559
R-HSA-5693538 Homology Directed Repair 2.763720e-01 0.559
R-HSA-1852241 Organelle biogenesis and maintenance 2.763829e-01 0.558
R-HSA-1482839 Acyl chain remodelling of PE 2.804028e-01 0.552
R-HSA-2559585 Oncogene Induced Senescence 2.804028e-01 0.552
R-HSA-3296482 Defects in vitamin and cofactor metabolism 2.804028e-01 0.552
R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 2.804028e-01 0.552
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 2.804028e-01 0.552
R-HSA-187687 Signalling to ERKs 2.804028e-01 0.552
R-HSA-422475 Axon guidance 2.831805e-01 0.548
R-HSA-388396 GPCR downstream signalling 2.840327e-01 0.547
R-HSA-74158 RNA Polymerase III Transcription 2.860262e-01 0.544
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 2.860262e-01 0.544
R-HSA-8941326 RUNX2 regulates bone development 2.860262e-01 0.544
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 2.908079e-01 0.536
R-HSA-2132295 MHC class II antigen presentation 2.908079e-01 0.536
R-HSA-4641257 Degradation of AXIN 2.916060e-01 0.535
R-HSA-196757 Metabolism of folate and pterines 2.916060e-01 0.535
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 2.971426e-01 0.527
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 2.971426e-01 0.527
R-HSA-69206 G1/S Transition 2.994545e-01 0.524
R-HSA-8953750 Transcriptional Regulation by E2F6 3.026362e-01 0.519
R-HSA-9648002 RAS processing 3.026362e-01 0.519
R-HSA-5696395 Formation of Incision Complex in GG-NER 3.080872e-01 0.511
R-HSA-177243 Interactions of Rev with host cellular proteins 3.080872e-01 0.511
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 3.113598e-01 0.507
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 3.134959e-01 0.504
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 3.134959e-01 0.504
R-HSA-73933 Resolution of Abasic Sites (AP sites) 3.134959e-01 0.504
R-HSA-3214841 PKMTs methylate histone lysines 3.134959e-01 0.504
R-HSA-199418 Negative regulation of the PI3K/AKT network 3.138277e-01 0.503
R-HSA-9006925 Intracellular signaling by second messengers 3.148676e-01 0.502
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 3.188627e-01 0.496
R-HSA-5576891 Cardiac conduction 3.195604e-01 0.495
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 3.241878e-01 0.489
R-HSA-73762 RNA Polymerase I Transcription Initiation 3.241878e-01 0.489
R-HSA-1280218 Adaptive Immune System 3.245251e-01 0.489
R-HSA-9675108 Nervous system development 3.337689e-01 0.477
R-HSA-3214858 RMTs methylate histone arginines 3.347145e-01 0.475
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 3.347145e-01 0.475
R-HSA-3928662 EPHB-mediated forward signaling 3.347145e-01 0.475
R-HSA-156581 Methylation 3.347145e-01 0.475
R-HSA-163685 Integration of energy metabolism 3.366878e-01 0.473
R-HSA-774815 Nucleosome assembly 3.399167e-01 0.469
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 3.399167e-01 0.469
R-HSA-4608870 Asymmetric localization of PCP proteins 3.399167e-01 0.469
R-HSA-9948299 Ribosome-associated quality control 3.423700e-01 0.466
R-HSA-72165 mRNA Splicing - Minor Pathway 3.450786e-01 0.462
R-HSA-9839373 Signaling by TGFBR3 3.450786e-01 0.462
R-HSA-6807070 PTEN Regulation 3.452056e-01 0.462
R-HSA-381119 Unfolded Protein Response (UPR) 3.452056e-01 0.462
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 3.502004e-01 0.456
R-HSA-196854 Metabolism of vitamins and cofactors 3.538134e-01 0.451
R-HSA-8953854 Metabolism of RNA 3.550930e-01 0.450
R-HSA-389661 Glyoxylate metabolism and glycine degradation 3.603250e-01 0.443
R-HSA-388841 Regulation of T cell activation by CD28 family 3.668004e-01 0.436
R-HSA-453279 Mitotic G1 phase and G1/S transition 3.677416e-01 0.434
R-HSA-199977 ER to Golgi Anterograde Transport 3.705385e-01 0.431
R-HSA-69620 Cell Cycle Checkpoints 3.710472e-01 0.431
R-HSA-73772 RNA Polymerase I Promoter Escape 3.752193e-01 0.426
R-HSA-72187 mRNA 3'-end processing 3.752193e-01 0.426
R-HSA-9634815 Transcriptional Regulation by NPAS4 3.752193e-01 0.426
R-HSA-9758941 Gastrulation 3.761177e-01 0.425
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 3.770007e-01 0.424
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.801072e-01 0.420
R-HSA-432722 Golgi Associated Vesicle Biogenesis 3.801072e-01 0.420
R-HSA-8948751 Regulation of PTEN stability and activity 3.801072e-01 0.420
R-HSA-372790 Signaling by GPCR 3.813376e-01 0.419
R-HSA-9734767 Developmental Cell Lineages 3.816416e-01 0.418
R-HSA-71291 Metabolism of amino acids and derivatives 3.840043e-01 0.416
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 3.844489e-01 0.415
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 3.849571e-01 0.415
R-HSA-5693532 DNA Double-Strand Break Repair 3.872156e-01 0.412
R-HSA-913531 Interferon Signaling 3.892700e-01 0.410
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 3.897694e-01 0.409
R-HSA-418597 G alpha (z) signalling events 3.897694e-01 0.409
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.899769e-01 0.409
R-HSA-193648 NRAGE signals death through JNK 3.945444e-01 0.404
R-HSA-5578775 Ion homeostasis 3.945444e-01 0.404
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 3.945444e-01 0.404
R-HSA-109606 Intrinsic Pathway for Apoptosis 3.945444e-01 0.404
R-HSA-2980766 Nuclear Envelope Breakdown 3.992823e-01 0.399
R-HSA-1483166 Synthesis of PA 3.992823e-01 0.399
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 3.992823e-01 0.399
R-HSA-9711097 Cellular response to starvation 4.009670e-01 0.397
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 4.009670e-01 0.397
R-HSA-877300 Interferon gamma signaling 4.037003e-01 0.394
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 4.039834e-01 0.394
R-HSA-9006936 Signaling by TGFB family members 4.064278e-01 0.391
R-HSA-429914 Deadenylation-dependent mRNA decay 4.086480e-01 0.389
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 4.086480e-01 0.389
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.096327e-01 0.388
R-HSA-5362517 Signaling by Retinoic Acid 4.132764e-01 0.384
R-HSA-373755 Semaphorin interactions 4.269470e-01 0.370
R-HSA-8953897 Cellular responses to stimuli 4.294228e-01 0.367
R-HSA-936837 Ion transport by P-type ATPases 4.314332e-01 0.365
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 4.314332e-01 0.365
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 4.360248e-01 0.360
R-HSA-5621481 C-type lectin receptors (CLRs) 4.386768e-01 0.358
R-HSA-5689880 Ub-specific processing proteases 4.439608e-01 0.353
R-HSA-196807 Nicotinate metabolism 4.446841e-01 0.352
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 4.490325e-01 0.348
R-HSA-204005 COPII-mediated vesicle transport 4.576284e-01 0.339
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 4.618764e-01 0.335
R-HSA-427413 NoRC negatively regulates rRNA expression 4.618764e-01 0.335
R-HSA-8978934 Metabolism of cofactors 4.618764e-01 0.335
R-HSA-2559583 Cellular Senescence 4.622372e-01 0.335
R-HSA-9924644 Developmental Lineages of the Mammary Gland 4.660913e-01 0.332
R-HSA-199992 trans-Golgi Network Vesicle Budding 4.660913e-01 0.332
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 4.702734e-01 0.328
R-HSA-73854 RNA Polymerase I Promoter Clearance 4.826259e-01 0.316
R-HSA-8868773 rRNA processing in the nucleus and cytosol 4.826939e-01 0.316
R-HSA-983712 Ion channel transport 4.852176e-01 0.314
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 4.866796e-01 0.313
R-HSA-383280 Nuclear Receptor transcription pathway 4.907017e-01 0.309
R-HSA-73864 RNA Polymerase I Transcription 4.907017e-01 0.309
R-HSA-4086400 PCP/CE pathway 4.907017e-01 0.309
R-HSA-416482 G alpha (12/13) signalling events 4.907017e-01 0.309
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 4.986524e-01 0.302
R-HSA-6806834 Signaling by MET 4.986524e-01 0.302
R-HSA-5693607 Processing of DNA double-strand break ends 5.025815e-01 0.299
R-HSA-212165 Epigenetic regulation of gene expression 5.042216e-01 0.297
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 5.064800e-01 0.295
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 5.141863e-01 0.289
R-HSA-390918 Peroxisomal lipid metabolism 5.141863e-01 0.289
R-HSA-948021 Transport to the Golgi and subsequent modification 5.173274e-01 0.286
R-HSA-5687128 MAPK6/MAPK4 signaling 5.179946e-01 0.286
R-HSA-6794362 Protein-protein interactions at synapses 5.179946e-01 0.286
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 5.197425e-01 0.284
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 5.255225e-01 0.279
R-HSA-1614635 Sulfur amino acid metabolism 5.255225e-01 0.279
R-HSA-438064 Post NMDA receptor activation events 5.292426e-01 0.276
R-HSA-73884 Base Excision Repair 5.402302e-01 0.267
R-HSA-1912408 Pre-NOTCH Transcription and Translation 5.438359e-01 0.265
R-HSA-8986944 Transcriptional Regulation by MECP2 5.438359e-01 0.265
R-HSA-1474290 Collagen formation 5.579802e-01 0.253
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 5.683021e-01 0.245
R-HSA-6807878 COPI-mediated anterograde transport 5.683021e-01 0.245
R-HSA-2262752 Cellular responses to stress 5.701998e-01 0.244
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.716893e-01 0.243
R-HSA-3214847 HATs acetylate histones 5.783849e-01 0.238
R-HSA-193704 p75 NTR receptor-mediated signalling 5.783849e-01 0.238
R-HSA-9705683 SARS-CoV-2-host interactions 5.796864e-01 0.237
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 5.882340e-01 0.230
R-HSA-2559580 Oxidative Stress Induced Senescence 5.882340e-01 0.230
R-HSA-9842860 Regulation of endogenous retroelements 5.882340e-01 0.230
R-HSA-72312 rRNA processing 5.884130e-01 0.230
R-HSA-5696398 Nucleotide Excision Repair 6.010119e-01 0.221
R-HSA-157118 Signaling by NOTCH 6.054655e-01 0.218
R-HSA-211000 Gene Silencing by RNA 6.072525e-01 0.217
R-HSA-2672351 Stimuli-sensing channels 6.103364e-01 0.214
R-HSA-202403 TCR signaling 6.164323e-01 0.210
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 6.283418e-01 0.202
R-HSA-5628897 TP53 Regulates Metabolic Genes 6.341582e-01 0.198
R-HSA-5688426 Deubiquitination 6.360000e-01 0.197
R-HSA-4420097 VEGFA-VEGFR2 Pathway 6.370325e-01 0.196
R-HSA-8878166 Transcriptional regulation by RUNX2 6.483072e-01 0.188
R-HSA-73886 Chromosome Maintenance 6.538135e-01 0.185
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.592343e-01 0.181
R-HSA-162909 Host Interactions of HIV factors 6.619131e-01 0.179
R-HSA-194138 Signaling by VEGF 6.672081e-01 0.176
R-HSA-446728 Cell junction organization 6.792140e-01 0.168
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 6.809955e-01 0.167
R-HSA-1474165 Reproduction 6.826044e-01 0.166
R-HSA-9843745 Adipogenesis 6.851008e-01 0.164
R-HSA-72766 Translation 6.869842e-01 0.163
R-HSA-8856688 Golgi-to-ER retrograde transport 6.875777e-01 0.163
R-HSA-9018519 Estrogen-dependent gene expression 6.996755e-01 0.155
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 7.113085e-01 0.148
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 7.158354e-01 0.145
R-HSA-162599 Late Phase of HIV Life Cycle 7.158354e-01 0.145
R-HSA-8856828 Clathrin-mediated endocytosis 7.180725e-01 0.144
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 7.230176e-01 0.141
R-HSA-9856651 MITF-M-dependent gene expression 7.332499e-01 0.135
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.353508e-01 0.134
R-HSA-168249 Innate Immune System 7.380948e-01 0.132
R-HSA-9609507 Protein localization 7.395037e-01 0.131
R-HSA-112316 Neuronal System 7.397997e-01 0.131
R-HSA-1500931 Cell-Cell communication 7.414312e-01 0.130
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 7.415558e-01 0.130
R-HSA-73887 Death Receptor Signaling 7.415558e-01 0.130
R-HSA-1989781 PPARA activates gene expression 7.435918e-01 0.129
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7.476164e-01 0.126
R-HSA-162587 HIV Life Cycle 7.476164e-01 0.126
R-HSA-449147 Signaling by Interleukins 7.483359e-01 0.126
R-HSA-112315 Transmission across Chemical Synapses 7.517091e-01 0.124
R-HSA-109582 Hemostasis 7.600486e-01 0.119
R-HSA-1474244 Extracellular matrix organization 7.630269e-01 0.117
R-HSA-199991 Membrane Trafficking 7.724067e-01 0.112
R-HSA-418555 G alpha (s) signalling events 7.758679e-01 0.110
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.776357e-01 0.109
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 7.793896e-01 0.108
R-HSA-9764265 Regulation of CDH1 Expression and Function 7.793896e-01 0.108
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.811298e-01 0.107
R-HSA-9694516 SARS-CoV-2 Infection 7.868805e-01 0.104
R-HSA-74160 Gene expression (Transcription) 7.942022e-01 0.100
R-HSA-73894 DNA Repair 8.004055e-01 0.097
R-HSA-9006931 Signaling by Nuclear Receptors 8.039610e-01 0.095
R-HSA-72163 mRNA Splicing - Major Pathway 8.132093e-01 0.090
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 8.161485e-01 0.088
R-HSA-389948 Co-inhibition by PD-1 8.218898e-01 0.085
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 8.218898e-01 0.085
R-HSA-72172 mRNA Splicing 8.288169e-01 0.082
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 8.393485e-01 0.076
R-HSA-9730414 MITF-M-regulated melanocyte development 8.406189e-01 0.075
R-HSA-418990 Adherens junctions interactions 8.468229e-01 0.072
R-HSA-8878171 Transcriptional regulation by RUNX1 8.562548e-01 0.067
R-HSA-162906 HIV Infection 8.573925e-01 0.067
R-HSA-446203 Asparagine N-linked glycosylation 8.642042e-01 0.063
R-HSA-1280215 Cytokine Signaling in Immune system 8.645129e-01 0.063
R-HSA-8939211 ESR-mediated signaling 8.682896e-01 0.061
R-HSA-156580 Phase II - Conjugation of compounds 8.703677e-01 0.060
R-HSA-73857 RNA Polymerase II Transcription 8.742281e-01 0.058
R-HSA-421270 Cell-cell junction organization 8.821709e-01 0.054
R-HSA-6798695 Neutrophil degranulation 8.910518e-01 0.050
R-HSA-9824446 Viral Infection Pathways 8.920954e-01 0.050
R-HSA-5653656 Vesicle-mediated transport 8.935153e-01 0.049
R-HSA-416476 G alpha (q) signalling events 8.937567e-01 0.049
R-HSA-9711123 Cellular response to chemical stress 8.970888e-01 0.047
R-HSA-168256 Immune System 8.993850e-01 0.046
R-HSA-76002 Platelet activation, signaling and aggregation 9.018934e-01 0.045
R-HSA-211945 Phase I - Functionalization of compounds 9.049721e-01 0.043
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 9.079550e-01 0.042
R-HSA-211859 Biological oxidations 9.288351e-01 0.032
R-HSA-212436 Generic Transcription Pathway 9.331670e-01 0.030
R-HSA-9679506 SARS-CoV Infections 9.423660e-01 0.026
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.592981e-01 0.018
R-HSA-8978868 Fatty acid metabolism 9.664343e-01 0.015
R-HSA-5668914 Diseases of metabolism 9.714220e-01 0.013
R-HSA-556833 Metabolism of lipids 9.814725e-01 0.008
R-HSA-5663205 Infectious disease 9.939940e-01 0.003
R-HSA-1430728 Metabolism 9.959017e-01 0.002
R-HSA-1643685 Disease 9.966132e-01 0.001
R-HSA-382551 Transport of small molecules 9.971440e-01 0.001
R-HSA-597592 Post-translational protein modification 9.976820e-01 0.001
R-HSA-392499 Metabolism of proteins 9.992357e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDK18CDK18 0.854 0.811 1 0.874
CDK19CDK19 0.853 0.785 1 0.871
CDK17CDK17 0.853 0.823 1 0.890
P38GP38G 0.850 0.834 1 0.899
HIPK2HIPK2 0.849 0.739 1 0.861
CDK7CDK7 0.849 0.789 1 0.845
CDK8CDK8 0.849 0.786 1 0.843
JNK2JNK2 0.849 0.843 1 0.882
ERK1ERK1 0.845 0.802 1 0.864
CDK3CDK3 0.844 0.729 1 0.886
KISKIS 0.843 0.701 1 0.824
CDK13CDK13 0.842 0.783 1 0.863
CDK5CDK5 0.841 0.770 1 0.817
CDK12CDK12 0.840 0.787 1 0.880
P38BP38B 0.840 0.803 1 0.843
JNK3JNK3 0.839 0.829 1 0.857
CDK16CDK16 0.839 0.778 1 0.883
P38DP38D 0.839 0.804 1 0.906
DYRK2DYRK2 0.837 0.717 1 0.789
CDK1CDK1 0.837 0.775 1 0.851
CDK14CDK14 0.834 0.775 1 0.850
CDK9CDK9 0.833 0.770 1 0.860
P38AP38A 0.832 0.776 1 0.792
DYRK4DYRK4 0.832 0.724 1 0.869
ERK2ERK2 0.832 0.795 1 0.820
DYRK1BDYRK1B 0.830 0.701 1 0.829
HIPK1HIPK1 0.829 0.666 1 0.779
HIPK4HIPK4 0.826 0.473 1 0.605
CDK10CDK10 0.824 0.715 1 0.860
DYRK1ADYRK1A 0.824 0.598 1 0.765
NLKNLK 0.823 0.701 1 0.619
HIPK3HIPK3 0.823 0.649 1 0.762
CDK4CDK4 0.822 0.764 1 0.887
CDK6CDK6 0.821 0.743 1 0.869
CLK3CLK3 0.819 0.466 1 0.565
ERK5ERK5 0.818 0.422 1 0.518
JNK1JNK1 0.818 0.738 1 0.873
MAKMAK 0.813 0.526 -2 0.830
CDK2CDK2 0.813 0.604 1 0.746
DYRK3DYRK3 0.811 0.528 1 0.744
SRPK1SRPK1 0.811 0.326 -3 0.715
ICKICK 0.807 0.380 -3 0.799
CLK1CLK1 0.802 0.387 -3 0.687
CDKL5CDKL5 0.802 0.190 -3 0.755
MTORMTOR 0.800 0.205 1 0.424
CDKL1CDKL1 0.798 0.166 -3 0.760
CLK4CLK4 0.797 0.354 -3 0.704
PRP4PRP4 0.797 0.445 -3 0.738
SRPK2SRPK2 0.796 0.251 -3 0.638
COTCOT 0.794 -0.029 2 0.791
MOKMOK 0.793 0.456 1 0.663
TBK1TBK1 0.793 -0.095 1 0.251
MOSMOS 0.791 0.030 1 0.287
CLK2CLK2 0.790 0.368 -3 0.695
PRKD1PRKD1 0.789 0.017 -3 0.792
IKKEIKKE 0.789 -0.105 1 0.253
ERK7ERK7 0.788 0.302 2 0.559
ULK2ULK2 0.788 -0.106 2 0.776
PRPKPRPK 0.787 -0.065 -1 0.864
CDC7CDC7 0.787 -0.091 1 0.235
GCN2GCN2 0.785 -0.162 2 0.783
NDR2NDR2 0.784 -0.019 -3 0.790
RAF1RAF1 0.784 -0.145 1 0.265
SKMLCKSKMLCK 0.784 0.010 -2 0.860
SRPK3SRPK3 0.783 0.205 -3 0.682
PDHK4PDHK4 0.783 -0.124 1 0.321
NEK6NEK6 0.783 -0.047 -2 0.791
WNK1WNK1 0.782 -0.049 -2 0.877
DSTYKDSTYK 0.782 -0.087 2 0.821
PKN3PKN3 0.782 -0.024 -3 0.775
RIPK3RIPK3 0.782 -0.069 3 0.838
PDHK1PDHK1 0.781 -0.138 1 0.310
CHAK2CHAK2 0.781 -0.018 -1 0.896
BMPR2BMPR2 0.780 -0.122 -2 0.856
ATRATR 0.780 -0.058 1 0.284
PKCDPKCD 0.780 0.007 2 0.727
CAMK1BCAMK1B 0.780 -0.040 -3 0.798
PIM3PIM3 0.780 -0.034 -3 0.785
ULK1ULK1 0.779 -0.113 -3 0.791
MST4MST4 0.779 -0.028 2 0.746
PRKD2PRKD2 0.779 0.005 -3 0.723
IKKBIKKB 0.778 -0.149 -2 0.723
MNK2MNK2 0.778 0.015 -2 0.797
NDR1NDR1 0.778 -0.054 -3 0.777
CAMLCKCAMLCK 0.778 0.003 -2 0.852
BCKDKBCKDK 0.777 -0.108 -1 0.856
NIKNIK 0.777 -0.045 -3 0.813
MLK2MLK2 0.777 -0.031 2 0.767
IRE1IRE1 0.776 -0.059 1 0.241
AURCAURC 0.776 0.041 -2 0.685
NEK7NEK7 0.776 -0.145 -3 0.798
WNK3WNK3 0.775 -0.166 1 0.261
TGFBR2TGFBR2 0.775 -0.096 -2 0.746
NUAK2NUAK2 0.775 -0.017 -3 0.762
P90RSKP90RSK 0.775 -0.014 -3 0.743
RSK3RSK3 0.774 -0.020 -3 0.723
MPSK1MPSK1 0.774 0.101 1 0.319
PAK3PAK3 0.774 -0.030 -2 0.807
NIM1NIM1 0.774 -0.046 3 0.832
RIPK1RIPK1 0.773 -0.133 1 0.237
HUNKHUNK 0.773 -0.116 2 0.790
MLK1MLK1 0.773 -0.119 2 0.766
PKN2PKN2 0.773 -0.059 -3 0.759
DAPK2DAPK2 0.773 -0.035 -3 0.806
MAPKAPK3MAPKAPK3 0.773 -0.053 -3 0.723
LATS2LATS2 0.772 -0.048 -5 0.639
PRKD3PRKD3 0.772 -0.006 -3 0.693
PKCAPKCA 0.771 0.013 2 0.679
PHKG1PHKG1 0.771 -0.040 -3 0.756
MARK4MARK4 0.771 -0.069 4 0.814
PAK1PAK1 0.771 -0.017 -2 0.812
TSSK1TSSK1 0.771 -0.051 -3 0.798
CAMK2GCAMK2G 0.771 -0.103 2 0.771
NEK9NEK9 0.771 -0.132 2 0.790
PLK4PLK4 0.771 -0.050 2 0.677
RSK2RSK2 0.771 -0.021 -3 0.728
IKKAIKKA 0.770 -0.072 -2 0.706
PINK1PINK1 0.770 0.169 1 0.451
MLK3MLK3 0.770 -0.021 2 0.690
AMPKA1AMPKA1 0.770 -0.078 -3 0.776
PKCZPKCZ 0.770 0.000 2 0.748
IRE2IRE2 0.769 -0.066 2 0.738
TSSK2TSSK2 0.769 -0.077 -5 0.752
PKCGPKCG 0.769 -0.009 2 0.688
GRK1GRK1 0.769 -0.015 -2 0.780
PAK6PAK6 0.769 -0.000 -2 0.727
MASTLMASTL 0.769 -0.142 -2 0.790
PKCBPKCB 0.768 -0.003 2 0.685
MAPKAPK2MAPKAPK2 0.768 -0.021 -3 0.689
CAMK2DCAMK2D 0.768 -0.077 -3 0.779
PKACGPKACG 0.768 -0.031 -2 0.748
PIM1PIM1 0.768 0.002 -3 0.714
ANKRD3ANKRD3 0.768 -0.123 1 0.272
NEK2NEK2 0.768 -0.073 2 0.785
LATS1LATS1 0.768 0.018 -3 0.825
DNAPKDNAPK 0.767 -0.029 1 0.286
MNK1MNK1 0.767 0.001 -2 0.809
ATMATM 0.767 -0.067 1 0.245
MELKMELK 0.766 -0.068 -3 0.739
VRK2VRK2 0.766 0.067 1 0.348
FAM20CFAM20C 0.766 0.049 2 0.666
P70S6KBP70S6KB 0.765 -0.038 -3 0.734
AMPKA2AMPKA2 0.765 -0.062 -3 0.749
NUAK1NUAK1 0.765 -0.050 -3 0.727
PKRPKR 0.765 -0.046 1 0.268
CHAK1CHAK1 0.765 -0.097 2 0.762
TTBK2TTBK2 0.764 -0.161 2 0.692
IRAK4IRAK4 0.764 -0.051 1 0.234
GRK5GRK5 0.764 -0.167 -3 0.774
SGK3SGK3 0.764 0.001 -3 0.690
AURBAURB 0.763 -0.002 -2 0.676
PKG2PKG2 0.763 0.000 -2 0.697
MSK2MSK2 0.762 -0.037 -3 0.694
DLKDLK 0.762 -0.186 1 0.255
PKCHPKCH 0.762 -0.037 2 0.700
PAK2PAK2 0.761 -0.058 -2 0.792
MLK4MLK4 0.761 -0.065 2 0.697
TGFBR1TGFBR1 0.761 -0.058 -2 0.762
YSK4YSK4 0.760 -0.119 1 0.248
BMPR1BBMPR1B 0.760 -0.056 1 0.197
CAMK4CAMK4 0.760 -0.129 -3 0.737
AKT2AKT2 0.760 0.021 -3 0.629
RSK4RSK4 0.760 -0.012 -3 0.705
GRK7GRK7 0.759 -0.001 1 0.253
SNRKSNRK 0.759 -0.116 2 0.728
PKCTPKCT 0.759 -0.025 2 0.698
SMG1SMG1 0.759 -0.079 1 0.269
ALK4ALK4 0.759 -0.082 -2 0.787
QSKQSK 0.758 -0.057 4 0.801
PKACBPKACB 0.758 0.012 -2 0.691
GRK6GRK6 0.758 -0.149 1 0.233
WNK4WNK4 0.758 -0.091 -2 0.852
GRK4GRK4 0.757 -0.164 -2 0.794
MEKK1MEKK1 0.757 -0.099 1 0.269
QIKQIK 0.756 -0.120 -3 0.755
TLK2TLK2 0.756 -0.108 1 0.242
SSTKSSTK 0.756 -0.025 4 0.812
PLK1PLK1 0.756 -0.137 -2 0.745
MSK1MSK1 0.755 -0.025 -3 0.692
MEK1MEK1 0.755 -0.148 2 0.801
DCAMKL1DCAMKL1 0.755 -0.043 -3 0.718
BRSK2BRSK2 0.755 -0.103 -3 0.742
MYLK4MYLK4 0.755 -0.043 -2 0.788
SIKSIK 0.754 -0.068 -3 0.694
ZAKZAK 0.754 -0.118 1 0.246
MEKK2MEKK2 0.754 -0.078 2 0.773
CAMK2BCAMK2B 0.754 -0.059 2 0.734
CAMK2ACAMK2A 0.753 -0.037 2 0.740
PERKPERK 0.753 -0.129 -2 0.795
AKT1AKT1 0.753 0.003 -3 0.643
NEK5NEK5 0.753 -0.090 1 0.250
BRAFBRAF 0.753 -0.089 -4 0.800
PAK5PAK5 0.753 -0.024 -2 0.666
MEK5MEK5 0.752 -0.132 2 0.793
PAK4PAK4 0.752 -0.006 -2 0.676
PHKG2PHKG2 0.752 -0.080 -3 0.718
BRSK1BRSK1 0.752 -0.085 -3 0.726
HRIHRI 0.752 -0.154 -2 0.811
MAPKAPK5MAPKAPK5 0.752 -0.086 -3 0.666
CHK1CHK1 0.752 -0.098 -3 0.763
DCAMKL2DCAMKL2 0.751 -0.054 -3 0.743
PIM2PIM2 0.751 -0.015 -3 0.687
MST3MST3 0.751 -0.042 2 0.764
PKCIPKCI 0.751 -0.016 2 0.723
AURAAURA 0.750 -0.030 -2 0.646
LKB1LKB1 0.750 -0.004 -3 0.777
ALK2ALK2 0.750 -0.088 -2 0.767
MAP3K15MAP3K15 0.750 -0.033 1 0.261
ACVR2AACVR2A 0.750 -0.114 -2 0.744
ACVR2BACVR2B 0.750 -0.111 -2 0.752
GSK3AGSK3A 0.749 0.148 4 0.331
PDK1PDK1 0.748 -0.040 1 0.291
MARK3MARK3 0.748 -0.076 4 0.743
TAO3TAO3 0.748 -0.047 1 0.283
SMMLCKSMMLCK 0.748 -0.037 -3 0.756
MARK2MARK2 0.747 -0.090 4 0.711
PKN1PKN1 0.747 -0.028 -3 0.659
CAMK1GCAMK1G 0.747 -0.073 -3 0.700
PRKXPRKX 0.747 0.014 -3 0.608
MEKK3MEKK3 0.747 -0.165 1 0.256
TLK1TLK1 0.747 -0.141 -2 0.780
AKT3AKT3 0.747 0.025 -3 0.580
DRAK1DRAK1 0.746 -0.147 1 0.187
NEK11NEK11 0.746 -0.110 1 0.279
BUB1BUB1 0.746 0.018 -5 0.664
PKACAPKACA 0.746 -0.003 -2 0.651
SBKSBK 0.746 0.097 -3 0.528
MEKK6MEKK6 0.745 -0.067 1 0.261
NEK4NEK4 0.745 -0.100 1 0.251
PLK3PLK3 0.745 -0.139 2 0.757
PKCEPKCE 0.744 -0.002 2 0.681
NEK8NEK8 0.744 -0.123 2 0.792
IRAK1IRAK1 0.743 -0.172 -1 0.815
HASPINHASPIN 0.743 0.072 -1 0.827
HGKHGK 0.743 -0.045 3 0.877
TAO2TAO2 0.742 -0.068 2 0.785
TTBK1TTBK1 0.742 -0.156 2 0.623
MARK1MARK1 0.741 -0.115 4 0.775
TNIKTNIK 0.741 -0.015 3 0.870
BMPR1ABMPR1A 0.741 -0.085 1 0.186
MINKMINK 0.740 -0.075 1 0.257
GCKGCK 0.740 -0.064 1 0.273
P70S6KP70S6K 0.740 -0.066 -3 0.650
GRK2GRK2 0.740 -0.116 -2 0.685
PBKPBK 0.740 -0.012 1 0.282
PDHK3_TYRPDHK3_TYR 0.739 0.178 4 0.885
CAMKK1CAMKK1 0.739 -0.145 -2 0.748
GAKGAK 0.739 -0.053 1 0.304
LRRK2LRRK2 0.739 -0.008 2 0.822
SGK1SGK1 0.738 0.023 -3 0.558
KHS1KHS1 0.738 -0.026 1 0.276
CAMK1DCAMK1D 0.737 -0.057 -3 0.619
LOKLOK 0.737 -0.057 -2 0.762
NEK1NEK1 0.737 -0.109 1 0.239
MRCKBMRCKB 0.737 -0.009 -3 0.668
LIMK2_TYRLIMK2_TYR 0.736 0.144 -3 0.839
RIPK2RIPK2 0.736 -0.163 1 0.232
CAMKK2CAMKK2 0.736 -0.118 -2 0.754
ROCK2ROCK2 0.735 -0.008 -3 0.716
HPK1HPK1 0.734 -0.074 1 0.275
CK1ECK1E 0.734 -0.072 -3 0.422
NEK3NEK3 0.734 -0.081 1 0.268
CHK2CHK2 0.734 -0.040 -3 0.578
DAPK3DAPK3 0.734 -0.046 -3 0.733
CAMK1ACAMK1A 0.734 -0.035 -3 0.608
MST2MST2 0.733 -0.124 1 0.255
YSK1YSK1 0.733 -0.078 2 0.760
TESK1_TYRTESK1_TYR 0.733 0.065 3 0.896
EEF2KEEF2K 0.733 -0.079 3 0.838
KHS2KHS2 0.733 -0.021 1 0.285
GSK3BGSK3B 0.733 -0.003 4 0.324
BIKEBIKE 0.732 -0.003 1 0.289
PKMYT1_TYRPKMYT1_TYR 0.732 0.135 3 0.888
PASKPASK 0.732 -0.093 -3 0.797
MRCKAMRCKA 0.730 -0.036 -3 0.688
PKG1PKG1 0.729 -0.027 -2 0.627
CK1G1CK1G1 0.729 -0.101 -3 0.447
SLKSLK 0.729 -0.062 -2 0.699
TAK1TAK1 0.729 -0.164 1 0.256
VRK1VRK1 0.729 -0.152 2 0.799
AAK1AAK1 0.729 0.028 1 0.285
ASK1ASK1 0.727 -0.068 1 0.260
PDHK4_TYRPDHK4_TYR 0.727 0.047 2 0.821
CSF1RCSF1R 0.727 -0.005 3 0.876
MEK2MEK2 0.726 -0.170 2 0.784
STK33STK33 0.726 -0.123 2 0.611
DMPK1DMPK1 0.726 0.006 -3 0.688
CK1DCK1D 0.725 -0.058 -3 0.373
MAP2K7_TYRMAP2K7_TYR 0.725 -0.053 2 0.829
MST1MST1 0.725 -0.141 1 0.248
MAP2K4_TYRMAP2K4_TYR 0.725 -0.002 -1 0.885
MST1RMST1R 0.725 -0.035 3 0.879
LIMK1_TYRLIMK1_TYR 0.725 0.026 2 0.823
RETRET 0.725 -0.077 1 0.278
TNK1TNK1 0.724 0.025 3 0.859
CRIKCRIK 0.724 -0.010 -3 0.657
JAK2JAK2 0.724 -0.053 1 0.292
MAP2K6_TYRMAP2K6_TYR 0.724 0.015 -1 0.891
ROS1ROS1 0.723 -0.053 3 0.860
DAPK1DAPK1 0.722 -0.066 -3 0.709
ROCK1ROCK1 0.722 -0.024 -3 0.680
TYRO3TYRO3 0.721 -0.078 3 0.876
CK2A2CK2A2 0.721 -0.077 1 0.160
TTKTTK 0.721 -0.060 -2 0.772
EPHA6EPHA6 0.721 -0.031 -1 0.854
OSR1OSR1 0.720 -0.062 2 0.750
GRK3GRK3 0.720 -0.127 -2 0.634
PINK1_TYRPINK1_TYR 0.720 -0.127 1 0.296
MYO3BMYO3B 0.720 -0.058 2 0.771
TYK2TYK2 0.719 -0.147 1 0.272
BMPR2_TYRBMPR2_TYR 0.719 -0.003 -1 0.883
JAK3JAK3 0.719 -0.061 1 0.259
TAO1TAO1 0.719 -0.083 1 0.259
CK1A2CK1A2 0.719 -0.084 -3 0.366
FGFR1FGFR1 0.719 0.023 3 0.852
TNK2TNK2 0.718 -0.019 3 0.839
PDHK1_TYRPDHK1_TYR 0.718 -0.075 -1 0.888
JAK1JAK1 0.717 -0.042 1 0.262
FGFR2FGFR2 0.717 0.005 3 0.859
TEKTEK 0.717 0.029 3 0.839
TNNI3K_TYRTNNI3K_TYR 0.717 -0.013 1 0.287
MYO3AMYO3A 0.717 -0.074 1 0.265
NEK10_TYRNEK10_TYR 0.717 -0.077 1 0.268
EPHB4EPHB4 0.716 -0.071 -1 0.824
PLK2PLK2 0.715 -0.112 -3 0.733
DDR1DDR1 0.715 -0.081 4 0.824
YES1YES1 0.714 -0.057 -1 0.813
TXKTXK 0.714 -0.042 1 0.198
KDRKDR 0.713 -0.032 3 0.849
LCKLCK 0.713 -0.044 -1 0.802
PDGFRBPDGFRB 0.713 -0.120 3 0.882
ABL2ABL2 0.712 -0.088 -1 0.799
INSRRINSRR 0.711 -0.082 3 0.838
KITKIT 0.711 -0.080 3 0.877
CK2A1CK2A1 0.711 -0.090 1 0.148
AXLAXL 0.711 -0.093 3 0.864
FLT3FLT3 0.710 -0.121 3 0.872
HCKHCK 0.710 -0.091 -1 0.802
BLKBLK 0.710 -0.033 -1 0.805
ALPHAK3ALPHAK3 0.708 -0.086 -1 0.778
ABL1ABL1 0.708 -0.103 -1 0.791
STLK3STLK3 0.708 -0.131 1 0.232
METMET 0.708 -0.065 3 0.862
PDGFRAPDGFRA 0.708 -0.140 3 0.880
MERTKMERTK 0.707 -0.089 3 0.853
FGRFGR 0.707 -0.146 1 0.230
FGFR3FGFR3 0.707 -0.017 3 0.843
ITKITK 0.706 -0.109 -1 0.794
FERFER 0.706 -0.158 1 0.236
DDR2DDR2 0.705 0.002 3 0.822
EPHA1EPHA1 0.704 -0.085 3 0.856
EPHB3EPHB3 0.704 -0.120 -1 0.804
EPHA4EPHA4 0.704 -0.081 2 0.738
EPHB1EPHB1 0.703 -0.136 1 0.212
SRMSSRMS 0.703 -0.137 1 0.208
EPHB2EPHB2 0.703 -0.110 -1 0.796
ALKALK 0.702 -0.112 3 0.813
FYNFYN 0.702 -0.037 -1 0.774
EPHA7EPHA7 0.701 -0.083 2 0.756
BMXBMX 0.700 -0.086 -1 0.703
FRKFRK 0.700 -0.101 -1 0.809
FLT4FLT4 0.699 -0.102 3 0.835
INSRINSR 0.699 -0.110 3 0.822
TECTEC 0.698 -0.123 -1 0.722
WEE1_TYRWEE1_TYR 0.698 -0.090 -1 0.772
LYNLYN 0.697 -0.087 3 0.814
BTKBTK 0.697 -0.176 -1 0.761
LTKLTK 0.697 -0.131 3 0.827
ERBB2ERBB2 0.697 -0.133 1 0.238
NTRK1NTRK1 0.696 -0.163 -1 0.812
NTRK2NTRK2 0.696 -0.156 3 0.839
FLT1FLT1 0.695 -0.115 -1 0.827
YANK3YANK3 0.694 -0.090 2 0.378
NTRK3NTRK3 0.694 -0.110 -1 0.757
EGFREGFR 0.693 -0.086 1 0.197
SRCSRC 0.693 -0.080 -1 0.768
EPHA3EPHA3 0.693 -0.123 2 0.726
FGFR4FGFR4 0.691 -0.076 -1 0.750
PTK2BPTK2B 0.691 -0.101 -1 0.758
EPHA8EPHA8 0.690 -0.091 -1 0.790
PTK6PTK6 0.689 -0.197 -1 0.724
MUSKMUSK 0.689 -0.112 1 0.185
MATKMATK 0.688 -0.099 -1 0.733
EPHA5EPHA5 0.688 -0.116 2 0.744
CSKCSK 0.687 -0.130 2 0.751
ERBB4ERBB4 0.684 -0.065 1 0.190
CK1ACK1A 0.682 -0.106 -3 0.288
IGF1RIGF1R 0.682 -0.118 3 0.770
EPHA2EPHA2 0.681 -0.099 -1 0.759
PTK2PTK2 0.679 -0.063 -1 0.786
SYKSYK 0.675 -0.089 -1 0.757
ZAP70ZAP70 0.668 -0.059 -1 0.700
FESFES 0.668 -0.124 -1 0.683
CK1G3CK1G3 0.660 -0.114 -3 0.244
YANK2YANK2 0.658 -0.114 2 0.393
CK1G2CK1G2 0.636 -0.116 -3 0.347