Motif 34 (n=118)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A1B0GUH1 | None | S413 | ochoa | Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) | The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000256|ARBA:ARBA00003631, ECO:0000256|RuleBase:RU003981}. |
I3L0D1 | RBAK-RBAKDN | S78 | ochoa | HCG1647537, isoform CRA_b (RBAK-RBAKDN readthrough) | None |
M0QX08 | None | S58 | ochoa | Protein kinase domain-containing protein | None |
O00562 | PITPNM1 | S896 | ochoa|psp | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
O14744 | PRMT5 | S310 | ochoa | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
O15375 | SLC16A5 | S451 | ochoa | Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5) | Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}. |
O75420 | GIGYF1 | S148 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O94913 | PCF11 | S705 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
O95271 | TNKS | S218 | ochoa | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}. |
O95279 | KCNK5 | S385 | ochoa | Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}. |
O95359 | TACC2 | S758 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
O95602 | POLR1A | S1695 | ochoa | DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) | Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity) (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). {ECO:0000250|UniProtKB:P10964, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}. |
O95936 | EOMES | S596 | ochoa | Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}. |
P00352 | ALDH1A1 | S75 | ochoa | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) | Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}. |
P09874 | PARP1 | S537 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
P10275 | AR | S651 | ochoa|psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
P15104 | GLUL | S322 | psp | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) | Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:16267323, PubMed:30158707, PubMed:36289327). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351). Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (PubMed:36289327). {ECO:0000250|UniProtKB:P15105, ECO:0000269|PubMed:16267323, ECO:0000269|PubMed:18662667, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:30158707, ECO:0000269|PubMed:36289327}. |
P18583 | SON | S1556 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
P18754 | RCC1 | S387 | psp | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
P24723 | PRKCH | S317 | ochoa | Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}. |
P29317 | EPHA2 | S277 | psp | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
P33241 | LSP1 | S111 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
P48681 | NES | S680 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
P48728 | AMT | S334 | ochoa | Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT) | The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000269|PubMed:16051266}. |
P53634 | CTSC | S329 | ochoa | Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] | Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). {ECO:0000269|PubMed:1586157, ECO:0000269|PubMed:8428921}. |
P53667 | LIMK1 | S210 | ochoa | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}. |
P53814 | SMTN | S729 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
P55327 | TPD52 | S40 | psp | Tumor protein D52 (Protein N8) | None |
P62750 | RPL23A | S43 | ochoa | Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}. |
Q02078 | MEF2A | S255 | ochoa|psp | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
Q05639 | EEF1A2 | S358 | psp | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
Q08499 | PDE4D | S255 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
Q09666 | AHNAK | S5552 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q13237 | PRKG2 | S97 | ochoa | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. |
Q14153 | FAM53B | S212 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
Q14160 | SCRIB | S1140 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14203 | DCTN1 | S105 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
Q14324 | MYBPC2 | S884 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
Q15149 | PLEC | S2958 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
Q15772 | SPEG | S2448 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q1MSJ5 | CSPP1 | S459 | ochoa | Centrosome and spindle pole-associated protein 1 | May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}. |
Q53EU6 | GPAT3 | S77 | ochoa | Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10) (AGPAT 10) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Acyl-CoA:glycerol-3-phosphate acyltransferase 3) (hGPAT3) (Lung cancer metastasis-associated protein 1) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta) (MAG-1) | Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:17170135, ECO:0000269|PubMed:19318427, ECO:0000269|PubMed:30846318}. |
Q58EX7 | PLEKHG4 | S716 | ochoa | Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) | Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. |
Q5JPE7 | NOMO2 | S1205 | ochoa | BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2) | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}. |
Q5JTV8 | TOR1AIP1 | S143 | ochoa|psp | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
Q5JTW2 | CEP78 | S654 | ochoa | Centrosomal protein of 78 kDa (Cep78) | Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:27246242, PubMed:27588451, PubMed:28242748, PubMed:34259627). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). Involved in cilium biogenesis and controls cilium length (PubMed:27588451). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:28242748, PubMed:34259627). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity). {ECO:0000250|UniProtKB:Q6IRU7, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}. |
Q5T8D3 | ACBD5 | S404 | ochoa | Acyl-CoA-binding domain-containing protein 5 | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}. |
Q5TCZ1 | SH3PXD2A | S644 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
Q5VWQ0 | RSBN1 | S547 | ochoa | Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) | Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}. |
Q659C4 | LARP1B | S633 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
Q684P5 | RAP1GAP2 | S668 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
Q69YU3 | ANKRD34A | S461 | ochoa | Ankyrin repeat domain-containing protein 34A | None |
Q6P435 | None | S111 | ochoa | Putative uncharacterized SMG1-like protein | None |
Q6PCB5 | RSBN1L | S536 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
Q6PIF6 | MYO7B | S934 | ochoa | Unconventional myosin-VIIb | Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length (PubMed:24725409, PubMed:26812018, PubMed:32209652). May link the complex to the actin core bundle of microvilli. {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018, ECO:0000269|PubMed:32209652, ECO:0000305|PubMed:24725409, ECO:0000305|PubMed:26812018}. |
Q6UB35 | MTHFD1L | S62 | ochoa | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}. |
Q702N8 | XIRP1 | S481 | ochoa | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}. |
Q709C8 | VPS13C | S1894 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
Q7L8C5 | SYT13 | S113 | ochoa | Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII) | May be involved in transport vesicle docking to the plasma membrane. {ECO:0000250}. |
Q7Z4K8 | TRIM46 | S627 | ochoa | Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein) | Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. {ECO:0000250|UniProtKB:Q7TNM2}. |
Q86W92 | PPFIBP1 | S37 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
Q86XL3 | ANKLE2 | S804 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
Q8IWU2 | LMTK2 | S1397 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
Q8IYK8 | REM2 | S295 | ochoa | GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) | Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}. |
Q8IZT6 | ASPM | S425 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
Q8N137 | CNTROB | S790 | ochoa | Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}. |
Q8NCD3 | HJURP | S642 | ochoa|psp | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
Q8NFC6 | BOD1L1 | S2501 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
Q8TF30 | WHAMM | S181 | ochoa | WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1) | Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}. |
Q8TF72 | SHROOM3 | S1662 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
Q8WUA4 | GTF3C2 | S25 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
Q8WUY3 | PRUNE2 | S576 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
Q8WXH2 | JPH3 | S457 | ochoa | Junctophilin-3 (JP-3) (Junctophilin type 3) (Trinucleotide repeat-containing gene 22 protein) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory. |
Q92613 | JADE3 | S695 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
Q93084 | ATP2A3 | S662 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
Q96F46 | IL17RA | S708 | ochoa|psp | Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. |
Q96I15 | SCLY | S129 | ochoa | Selenocysteine lyase (hSCL) (EC 4.4.1.16) | Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. {ECO:0000250|UniProtKB:Q68FT9}. |
Q96JA1 | LRIG1 | S975 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}. |
Q96JZ2 | HSH2D | S276 | ochoa | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
Q96PE2 | ARHGEF17 | S332 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
Q96PE2 | ARHGEF17 | S619 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
Q96Q15 | SMG1 | S115 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
Q96QT4 | TRPM7 | S1543 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
Q99707 | MTR | S156 | ochoa | Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase) | Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:16769880, PubMed:17288554, PubMed:27771510). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed:16769880, PubMed:17288554, PubMed:27771510). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:16769880, PubMed:27771510). {ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17288554, ECO:0000269|PubMed:27771510}. |
Q9BR39 | JPH2 | S157 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
Q9BRS8 | LARP6 | S384 | ochoa | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
Q9BRS8 | LARP6 | S409 | ochoa|psp | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
Q9BW04 | SARG | S519 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
Q9BY89 | KIAA1671 | S558 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9BY89 | KIAA1671 | S1224 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9BZ71 | PITPNM3 | S612 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
Q9C073 | FAM117A | S207 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
Q9H9B1 | EHMT1 | S1004 | ochoa | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}. |
Q9HAN9 | NMNAT1 | S117 | ochoa | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity (By similarity). {ECO:0000250|UniProtKB:Q9EPA7, ECO:0000269|PubMed:17402747, ECO:0000269|PubMed:27257257}. |
Q9NWQ8 | PAG1 | S288 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
Q9NYW8 | RBAK | S78 | ochoa | RB-associated KRAB zinc finger protein (RB-associated KRAB repressor) (hRBaK) (Zinc finger protein 769) | May repress E2F-dependent transcription. May promote AR-dependent transcription. {ECO:0000269|PubMed:10702291, ECO:0000269|PubMed:14664718}. |
Q9UBU6 | FAM8A1 | S229 | ochoa | Protein FAM8A1 (Autosomal highly conserved protein) | Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}. |
Q9UDY2 | TJP2 | S130 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
Q9UDY4 | DNAJB4 | S148 | ochoa | DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) | Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
Q9UF56 | FBXL17 | S303 | ochoa | F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) | Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9QZN1, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:30190310}. |
Q9UKS6 | PACSIN3 | S341 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
Q9UNS1 | TIMELESS | S1087 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
Q9UPP1 | PHF8 | S120 | ochoa|psp | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
Q9UPQ0 | LIMCH1 | S601 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9UPQ9 | TNRC6B | S803 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
Q9Y2H9 | MAST1 | S1413 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
Q9Y2I6 | NINL | S191 | ochoa | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
Q9Y2U8 | LEMD3 | S402 | ochoa|psp | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
Q9Y2W1 | THRAP3 | S560 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
Q9Y4Z2 | NEUROG3 | S174 | psp | Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5) | Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}. |
P62714 | PPP2CB | Y80 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
P67775 | PPP2CA | Y80 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}. |
O15264 | MAPK13 | S27 | Sugiyama | Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212, ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148, ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666, ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}. |
P17813 | ENG | S521 | Sugiyama | Endoglin (CD antigen CD105) | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484, ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}. |
Q15751 | HERC1 | S3238 | Sugiyama | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
P16298 | PPP3CB | Y122 | Sugiyama | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity). {ECO:0000250|UniProtKB:P48453, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:32753672}. |
P48454 | PPP3CC | Y109 | Sugiyama | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. {ECO:0000269|PubMed:19154138}. |
Q08209 | PPP3CA | Y113 | Sugiyama | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-180024 | DARPP-32 events | 4.153689e-07 | 6.382 |
R-HSA-68886 | M Phase | 8.383300e-05 | 4.077 |
R-HSA-111885 | Opioid Signalling | 3.145834e-04 | 3.502 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.315385e-03 | 2.881 |
R-HSA-198753 | ERK/MAPK targets | 1.181265e-03 | 2.928 |
R-HSA-69275 | G2/M Transition | 1.225028e-03 | 2.912 |
R-HSA-453274 | Mitotic G2-G2/M phases | 1.294548e-03 | 2.888 |
R-HSA-68875 | Mitotic Prophase | 6.983450e-04 | 3.156 |
R-HSA-69278 | Cell Cycle, Mitotic | 7.331632e-04 | 3.135 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.467783e-03 | 2.608 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.467783e-03 | 2.608 |
R-HSA-8854518 | AURKA Activation by TPX2 | 2.860402e-03 | 2.544 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.738247e-03 | 2.563 |
R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 2.885417e-03 | 2.540 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 5.541290e-03 | 2.256 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 5.541290e-03 | 2.256 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 5.541290e-03 | 2.256 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 6.328885e-03 | 2.199 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 7.164336e-03 | 2.145 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 7.164336e-03 | 2.145 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 7.164336e-03 | 2.145 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 7.164336e-03 | 2.145 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 7.164336e-03 | 2.145 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.938432e-03 | 2.405 |
R-HSA-380287 | Centrosome maturation | 4.290668e-03 | 2.367 |
R-HSA-2025928 | Calcineurin activates NFAT | 4.112837e-03 | 2.386 |
R-HSA-4791275 | Signaling by WNT in cancer | 3.445472e-03 | 2.463 |
R-HSA-4839744 | Signaling by APC mutants | 5.541290e-03 | 2.256 |
R-HSA-202670 | ERKs are inactivated | 6.328885e-03 | 2.199 |
R-HSA-4839735 | Signaling by AXIN mutants | 6.328885e-03 | 2.199 |
R-HSA-4839748 | Signaling by AMER1 mutants | 6.328885e-03 | 2.199 |
R-HSA-1483226 | Synthesis of PI | 5.541290e-03 | 2.256 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 6.328885e-03 | 2.199 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.139405e-03 | 2.212 |
R-HSA-68877 | Mitotic Prometaphase | 6.709804e-03 | 2.173 |
R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 4.112837e-03 | 2.386 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.262926e-03 | 2.279 |
R-HSA-4086398 | Ca2+ pathway | 3.938432e-03 | 2.405 |
R-HSA-195721 | Signaling by WNT | 3.706498e-03 | 2.431 |
R-HSA-448424 | Interleukin-17 signaling | 3.447644e-03 | 2.462 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.703708e-03 | 2.431 |
R-HSA-1640170 | Cell Cycle | 4.826212e-03 | 2.316 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.329781e-03 | 2.135 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.365022e-03 | 2.133 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.897274e-03 | 2.103 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 9.950047e-03 | 2.002 |
R-HSA-1295596 | Spry regulation of FGF signaling | 9.950047e-03 | 2.002 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 8.975685e-03 | 2.047 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 9.034516e-03 | 2.044 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.096919e-02 | 1.960 |
R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 1.096919e-02 | 1.960 |
R-HSA-68882 | Mitotic Anaphase | 1.099302e-02 | 1.959 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.120545e-02 | 1.951 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.676704e-02 | 1.776 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.676704e-02 | 1.776 |
R-HSA-9754189 | Germ layer formation at gastrulation | 1.547881e-02 | 1.810 |
R-HSA-389513 | Co-inhibition by CTLA4 | 1.671085e-02 | 1.777 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.428791e-02 | 1.845 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 1.547881e-02 | 1.810 |
R-HSA-418346 | Platelet homeostasis | 1.424494e-02 | 1.846 |
R-HSA-432142 | Platelet sensitization by LDL | 1.428791e-02 | 1.845 |
R-HSA-450294 | MAP kinase activation | 1.732827e-02 | 1.761 |
R-HSA-5545619 | XAV939 stabilizes AXIN | 2.320265e-02 | 1.634 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.346386e-02 | 1.630 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.796561e-02 | 1.553 |
R-HSA-525793 | Myogenesis | 2.642907e-02 | 1.578 |
R-HSA-162582 | Signal Transduction | 2.813837e-02 | 1.551 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.539989e-02 | 1.595 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.652307e-02 | 1.576 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.953726e-02 | 1.530 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.114338e-02 | 1.507 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.616239e-02 | 1.442 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.790024e-02 | 1.421 |
R-HSA-141424 | Amplification of signal from the kinetochores | 3.812394e-02 | 1.419 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.812394e-02 | 1.419 |
R-HSA-8941237 | Invadopodia formation | 3.837356e-02 | 1.416 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.146966e-02 | 1.382 |
R-HSA-5673000 | RAF activation | 4.146966e-02 | 1.382 |
R-HSA-166520 | Signaling by NTRKs | 4.210613e-02 | 1.376 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.330005e-02 | 1.364 |
R-HSA-6804757 | Regulation of TP53 Degradation | 4.516013e-02 | 1.345 |
R-HSA-3359467 | Defective MTRR causes HMAE | 6.069270e-02 | 1.217 |
R-HSA-426496 | Post-transcriptional silencing by small RNAs | 5.331068e-02 | 1.273 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 5.715548e-02 | 1.243 |
R-HSA-156842 | Eukaryotic Translation Elongation | 4.660309e-02 | 1.332 |
R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 6.069270e-02 | 1.217 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.091288e-02 | 1.293 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.488631e-02 | 1.261 |
R-HSA-5654743 | Signaling by FGFR4 | 6.104314e-02 | 1.214 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 5.691289e-02 | 1.245 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.091288e-02 | 1.293 |
R-HSA-5633007 | Regulation of TP53 Activity | 5.191460e-02 | 1.285 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.471985e-02 | 1.262 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.471985e-02 | 1.262 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.471985e-02 | 1.262 |
R-HSA-69236 | G1 Phase | 6.314578e-02 | 1.200 |
R-HSA-69231 | Cyclin D associated events in G1 | 6.314578e-02 | 1.200 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.476505e-02 | 1.189 |
R-HSA-5654741 | Signaling by FGFR3 | 6.527275e-02 | 1.185 |
R-HSA-75153 | Apoptotic execution phase | 6.742356e-02 | 1.171 |
R-HSA-210746 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | 6.801760e-02 | 1.167 |
R-HSA-3359469 | Defective MTR causes HMAG | 6.801760e-02 | 1.167 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.873649e-02 | 1.163 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.873649e-02 | 1.163 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.008449e-02 | 1.154 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.008449e-02 | 1.154 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.144445e-02 | 1.146 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 7.144445e-02 | 1.146 |
R-HSA-389356 | Co-stimulation by CD28 | 7.179470e-02 | 1.144 |
R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 7.528583e-02 | 1.123 |
R-HSA-446107 | Type I hemidesmosome assembly | 8.249783e-02 | 1.084 |
R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 8.249783e-02 | 1.084 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.038007e-01 | 0.984 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.022240e-01 | 0.990 |
R-HSA-191859 | snRNP Assembly | 9.733632e-02 | 1.012 |
R-HSA-194441 | Metabolism of non-coding RNA | 9.733632e-02 | 1.012 |
R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 8.249783e-02 | 1.084 |
R-HSA-192814 | vRNA Synthesis | 1.038007e-01 | 0.984 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.107920e-01 | 0.955 |
R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 8.249783e-02 | 1.084 |
R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 8.249783e-02 | 1.084 |
R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.107920e-01 | 0.955 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.017446e-02 | 1.045 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 7.528583e-02 | 1.123 |
R-HSA-186712 | Regulation of beta-cell development | 9.733632e-02 | 1.012 |
R-HSA-5617833 | Cilium Assembly | 8.248976e-02 | 1.084 |
R-HSA-5654736 | Signaling by FGFR1 | 9.013677e-02 | 1.045 |
R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 7.528583e-02 | 1.123 |
R-HSA-9010642 | ROBO receptors bind AKAP5 | 8.249783e-02 | 1.084 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 8.249783e-02 | 1.084 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.965402e-02 | 1.047 |
R-HSA-376176 | Signaling by ROBO receptors | 9.745847e-02 | 1.011 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.745847e-02 | 1.011 |
R-HSA-177929 | Signaling by EGFR | 9.013677e-02 | 1.045 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.716968e-02 | 1.060 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.716968e-02 | 1.060 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 9.169303e-02 | 1.038 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 9.169303e-02 | 1.038 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.559527e-02 | 1.122 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.985077e-02 | 1.098 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.382204e-01 | 0.859 |
R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 1.777968e-01 | 0.750 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.905840e-01 | 0.720 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.905840e-01 | 0.720 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.905840e-01 | 0.720 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 1.969034e-01 | 0.706 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.031739e-01 | 0.692 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.846739e-01 | 0.734 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.874825e-01 | 0.727 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.987745e-01 | 0.702 |
R-HSA-192823 | Viral mRNA Translation | 2.244523e-01 | 0.649 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 1.969034e-01 | 0.706 |
R-HSA-156902 | Peptide chain elongation | 1.762873e-01 | 0.754 |
R-HSA-418457 | cGMP effects | 1.314430e-01 | 0.881 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.277737e-01 | 0.642 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.277737e-01 | 0.642 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.016107e-01 | 0.695 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.314430e-01 | 0.881 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.382204e-01 | 0.859 |
R-HSA-9823730 | Formation of definitive endoderm | 1.777968e-01 | 0.750 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.516181e-01 | 0.819 |
R-HSA-72764 | Eukaryotic Translation Termination | 2.016107e-01 | 0.695 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.216953e-01 | 0.654 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.249965e-01 | 0.903 |
R-HSA-9603798 | Class I peroxisomal membrane protein import | 1.449453e-01 | 0.839 |
R-HSA-5576886 | Phase 4 - resting membrane potential | 1.449453e-01 | 0.839 |
R-HSA-9839394 | TGFBR3 expression | 2.155695e-01 | 0.666 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 2.016107e-01 | 0.695 |
R-HSA-392517 | Rap1 signalling | 1.713283e-01 | 0.766 |
R-HSA-9620244 | Long-term potentiation | 2.155695e-01 | 0.666 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.246128e-01 | 0.904 |
R-HSA-9708530 | Regulation of BACH1 activity | 1.449453e-01 | 0.839 |
R-HSA-9759218 | Cobalamin (Cbl) metabolism | 2.277737e-01 | 0.642 |
R-HSA-6783984 | Glycine degradation | 1.516181e-01 | 0.819 |
R-HSA-6807004 | Negative regulation of MET activity | 1.777968e-01 | 0.750 |
R-HSA-1257604 | PIP3 activates AKT signaling | 2.337821e-01 | 0.631 |
R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.277737e-01 | 0.642 |
R-HSA-2682334 | EPH-Ephrin signaling | 1.902971e-01 | 0.721 |
R-HSA-2408557 | Selenocysteine synthesis | 2.187199e-01 | 0.660 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.216953e-01 | 0.654 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.905840e-01 | 0.720 |
R-HSA-429947 | Deadenylation of mRNA | 2.093958e-01 | 0.679 |
R-HSA-1482801 | Acyl chain remodelling of PS | 2.155695e-01 | 0.666 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.273230e-01 | 0.643 |
R-HSA-2467813 | Separation of Sister Chromatids | 1.715470e-01 | 0.766 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.198341e-01 | 0.921 |
R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 2.155695e-01 | 0.666 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.545869e-01 | 0.811 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.382204e-01 | 0.859 |
R-HSA-171007 | p38MAPK events | 1.382204e-01 | 0.859 |
R-HSA-70350 | Fructose catabolism | 1.449453e-01 | 0.839 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 1.842153e-01 | 0.735 |
R-HSA-3247509 | Chromatin modifying enzymes | 1.391673e-01 | 0.856 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.582393e-01 | 0.801 |
R-HSA-3214842 | HDMs demethylate histones | 2.155695e-01 | 0.666 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.449453e-01 | 0.839 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.648092e-01 | 0.783 |
R-HSA-4839726 | Chromatin organization | 1.608310e-01 | 0.794 |
R-HSA-5654738 | Signaling by FGFR2 | 1.515440e-01 | 0.819 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.777968e-01 | 0.750 |
R-HSA-5652084 | Fructose metabolism | 1.969034e-01 | 0.706 |
R-HSA-3295583 | TRP channels | 2.216953e-01 | 0.654 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.249965e-01 | 0.903 |
R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 1.713283e-01 | 0.766 |
R-HSA-71384 | Ethanol oxidation | 1.969034e-01 | 0.706 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 2.273230e-01 | 0.643 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 2.109468e-01 | 0.676 |
R-HSA-2028269 | Signaling by Hippo | 1.582393e-01 | 0.801 |
R-HSA-167044 | Signalling to RAS | 1.842153e-01 | 0.735 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.216953e-01 | 0.654 |
R-HSA-180292 | GAB1 signalosome | 1.648092e-01 | 0.783 |
R-HSA-2408522 | Selenoamino acid metabolism | 1.715470e-01 | 0.766 |
R-HSA-400685 | Sema4D in semaphorin signaling | 2.155695e-01 | 0.666 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.969034e-01 | 0.706 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.044517e-01 | 0.689 |
R-HSA-5673001 | RAF/MAP kinase cascade | 2.238103e-01 | 0.650 |
R-HSA-5683057 | MAPK family signaling cascades | 1.615447e-01 | 0.792 |
R-HSA-418594 | G alpha (i) signalling events | 1.203246e-01 | 0.920 |
R-HSA-9827857 | Specification of primordial germ cells | 1.582393e-01 | 0.801 |
R-HSA-168255 | Influenza Infection | 2.029033e-01 | 0.693 |
R-HSA-190236 | Signaling by FGFR | 2.101471e-01 | 0.677 |
R-HSA-70171 | Glycolysis | 2.158586e-01 | 0.666 |
R-HSA-1483257 | Phospholipid metabolism | 2.337821e-01 | 0.631 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.821106e-01 | 0.740 |
R-HSA-9833482 | PKR-mediated signaling | 1.515440e-01 | 0.819 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 1.707314e-01 | 0.768 |
R-HSA-109581 | Apoptosis | 1.677319e-01 | 0.775 |
R-HSA-381070 | IRE1alpha activates chaperones | 1.874825e-01 | 0.727 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.417907e-01 | 0.848 |
R-HSA-168898 | Toll-like Receptor Cascades | 2.272382e-01 | 0.644 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.338050e-01 | 0.631 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.354548e-01 | 0.628 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.388306e-01 | 0.622 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.388306e-01 | 0.622 |
R-HSA-9700206 | Signaling by ALK in cancer | 2.388306e-01 | 0.622 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.397896e-01 | 0.620 |
R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 2.397896e-01 | 0.620 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.397896e-01 | 0.620 |
R-HSA-418360 | Platelet calcium homeostasis | 2.397896e-01 | 0.620 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.417127e-01 | 0.617 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.417127e-01 | 0.617 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.457278e-01 | 0.610 |
R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.457278e-01 | 0.610 |
R-HSA-114452 | Activation of BH3-only proteins | 2.457278e-01 | 0.610 |
R-HSA-5694530 | Cargo concentration in the ER | 2.516200e-01 | 0.599 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.561440e-01 | 0.592 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.574665e-01 | 0.589 |
R-HSA-5357801 | Programmed Cell Death | 2.583818e-01 | 0.588 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.590331e-01 | 0.587 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.632677e-01 | 0.580 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.632677e-01 | 0.580 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.632677e-01 | 0.580 |
R-HSA-9733709 | Cardiogenesis | 2.632677e-01 | 0.580 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 2.677027e-01 | 0.572 |
R-HSA-390522 | Striated Muscle Contraction | 2.690239e-01 | 0.570 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.690239e-01 | 0.570 |
R-HSA-1482788 | Acyl chain remodelling of PC | 2.690239e-01 | 0.570 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 2.690239e-01 | 0.570 |
R-HSA-8964539 | Glutamate and glutamine metabolism | 2.690239e-01 | 0.570 |
R-HSA-72613 | Eukaryotic Translation Initiation | 2.705927e-01 | 0.568 |
R-HSA-72737 | Cap-dependent Translation Initiation | 2.705927e-01 | 0.568 |
R-HSA-397014 | Muscle contraction | 2.731172e-01 | 0.564 |
R-HSA-70326 | Glucose metabolism | 2.734825e-01 | 0.563 |
R-HSA-5696400 | Dual Incision in GG-NER | 2.747355e-01 | 0.561 |
R-HSA-180746 | Nuclear import of Rev protein | 2.747355e-01 | 0.561 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.747355e-01 | 0.561 |
R-HSA-5365859 | RA biosynthesis pathway | 2.747355e-01 | 0.561 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 2.747355e-01 | 0.561 |
R-HSA-1266738 | Developmental Biology | 2.761104e-01 | 0.559 |
R-HSA-5693538 | Homology Directed Repair | 2.763720e-01 | 0.559 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 2.763829e-01 | 0.558 |
R-HSA-1482839 | Acyl chain remodelling of PE | 2.804028e-01 | 0.552 |
R-HSA-2559585 | Oncogene Induced Senescence | 2.804028e-01 | 0.552 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 2.804028e-01 | 0.552 |
R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 2.804028e-01 | 0.552 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.804028e-01 | 0.552 |
R-HSA-187687 | Signalling to ERKs | 2.804028e-01 | 0.552 |
R-HSA-422475 | Axon guidance | 2.831805e-01 | 0.548 |
R-HSA-388396 | GPCR downstream signalling | 2.840327e-01 | 0.547 |
R-HSA-74158 | RNA Polymerase III Transcription | 2.860262e-01 | 0.544 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.860262e-01 | 0.544 |
R-HSA-8941326 | RUNX2 regulates bone development | 2.860262e-01 | 0.544 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.908079e-01 | 0.536 |
R-HSA-2132295 | MHC class II antigen presentation | 2.908079e-01 | 0.536 |
R-HSA-4641257 | Degradation of AXIN | 2.916060e-01 | 0.535 |
R-HSA-196757 | Metabolism of folate and pterines | 2.916060e-01 | 0.535 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.971426e-01 | 0.527 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.971426e-01 | 0.527 |
R-HSA-69206 | G1/S Transition | 2.994545e-01 | 0.524 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.026362e-01 | 0.519 |
R-HSA-9648002 | RAS processing | 3.026362e-01 | 0.519 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.080872e-01 | 0.511 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.080872e-01 | 0.511 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 3.113598e-01 | 0.507 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.134959e-01 | 0.504 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.134959e-01 | 0.504 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.134959e-01 | 0.504 |
R-HSA-3214841 | PKMTs methylate histone lysines | 3.134959e-01 | 0.504 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.138277e-01 | 0.503 |
R-HSA-9006925 | Intracellular signaling by second messengers | 3.148676e-01 | 0.502 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.188627e-01 | 0.496 |
R-HSA-5576891 | Cardiac conduction | 3.195604e-01 | 0.495 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 3.241878e-01 | 0.489 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.241878e-01 | 0.489 |
R-HSA-1280218 | Adaptive Immune System | 3.245251e-01 | 0.489 |
R-HSA-9675108 | Nervous system development | 3.337689e-01 | 0.477 |
R-HSA-3214858 | RMTs methylate histone arginines | 3.347145e-01 | 0.475 |
R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 3.347145e-01 | 0.475 |
R-HSA-3928662 | EPHB-mediated forward signaling | 3.347145e-01 | 0.475 |
R-HSA-156581 | Methylation | 3.347145e-01 | 0.475 |
R-HSA-163685 | Integration of energy metabolism | 3.366878e-01 | 0.473 |
R-HSA-774815 | Nucleosome assembly | 3.399167e-01 | 0.469 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.399167e-01 | 0.469 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.399167e-01 | 0.469 |
R-HSA-9948299 | Ribosome-associated quality control | 3.423700e-01 | 0.466 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.450786e-01 | 0.462 |
R-HSA-9839373 | Signaling by TGFBR3 | 3.450786e-01 | 0.462 |
R-HSA-6807070 | PTEN Regulation | 3.452056e-01 | 0.462 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 3.452056e-01 | 0.462 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.502004e-01 | 0.456 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 3.538134e-01 | 0.451 |
R-HSA-8953854 | Metabolism of RNA | 3.550930e-01 | 0.450 |
R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 3.603250e-01 | 0.443 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.668004e-01 | 0.436 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.677416e-01 | 0.434 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 3.705385e-01 | 0.431 |
R-HSA-69620 | Cell Cycle Checkpoints | 3.710472e-01 | 0.431 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.752193e-01 | 0.426 |
R-HSA-72187 | mRNA 3'-end processing | 3.752193e-01 | 0.426 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.752193e-01 | 0.426 |
R-HSA-9758941 | Gastrulation | 3.761177e-01 | 0.425 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.770007e-01 | 0.424 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.801072e-01 | 0.420 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.801072e-01 | 0.420 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 3.801072e-01 | 0.420 |
R-HSA-372790 | Signaling by GPCR | 3.813376e-01 | 0.419 |
R-HSA-9734767 | Developmental Cell Lineages | 3.816416e-01 | 0.418 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 3.840043e-01 | 0.416 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.844489e-01 | 0.415 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.849571e-01 | 0.415 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 3.872156e-01 | 0.412 |
R-HSA-913531 | Interferon Signaling | 3.892700e-01 | 0.410 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.897694e-01 | 0.409 |
R-HSA-418597 | G alpha (z) signalling events | 3.897694e-01 | 0.409 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.899769e-01 | 0.409 |
R-HSA-193648 | NRAGE signals death through JNK | 3.945444e-01 | 0.404 |
R-HSA-5578775 | Ion homeostasis | 3.945444e-01 | 0.404 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.945444e-01 | 0.404 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.945444e-01 | 0.404 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 3.992823e-01 | 0.399 |
R-HSA-1483166 | Synthesis of PA | 3.992823e-01 | 0.399 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.992823e-01 | 0.399 |
R-HSA-9711097 | Cellular response to starvation | 4.009670e-01 | 0.397 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.009670e-01 | 0.397 |
R-HSA-877300 | Interferon gamma signaling | 4.037003e-01 | 0.394 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.039834e-01 | 0.394 |
R-HSA-9006936 | Signaling by TGFB family members | 4.064278e-01 | 0.391 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.086480e-01 | 0.389 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.086480e-01 | 0.389 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.096327e-01 | 0.388 |
R-HSA-5362517 | Signaling by Retinoic Acid | 4.132764e-01 | 0.384 |
R-HSA-373755 | Semaphorin interactions | 4.269470e-01 | 0.370 |
R-HSA-8953897 | Cellular responses to stimuli | 4.294228e-01 | 0.367 |
R-HSA-936837 | Ion transport by P-type ATPases | 4.314332e-01 | 0.365 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.314332e-01 | 0.365 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.360248e-01 | 0.360 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.386768e-01 | 0.358 |
R-HSA-5689880 | Ub-specific processing proteases | 4.439608e-01 | 0.353 |
R-HSA-196807 | Nicotinate metabolism | 4.446841e-01 | 0.352 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.490325e-01 | 0.348 |
R-HSA-204005 | COPII-mediated vesicle transport | 4.576284e-01 | 0.339 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.618764e-01 | 0.335 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.618764e-01 | 0.335 |
R-HSA-8978934 | Metabolism of cofactors | 4.618764e-01 | 0.335 |
R-HSA-2559583 | Cellular Senescence | 4.622372e-01 | 0.335 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 4.660913e-01 | 0.332 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.660913e-01 | 0.332 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.702734e-01 | 0.328 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.826259e-01 | 0.316 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.826939e-01 | 0.316 |
R-HSA-983712 | Ion channel transport | 4.852176e-01 | 0.314 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.866796e-01 | 0.313 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 4.907017e-01 | 0.309 |
R-HSA-73864 | RNA Polymerase I Transcription | 4.907017e-01 | 0.309 |
R-HSA-4086400 | PCP/CE pathway | 4.907017e-01 | 0.309 |
R-HSA-416482 | G alpha (12/13) signalling events | 4.907017e-01 | 0.309 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.986524e-01 | 0.302 |
R-HSA-6806834 | Signaling by MET | 4.986524e-01 | 0.302 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 5.025815e-01 | 0.299 |
R-HSA-212165 | Epigenetic regulation of gene expression | 5.042216e-01 | 0.297 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.064800e-01 | 0.295 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.141863e-01 | 0.289 |
R-HSA-390918 | Peroxisomal lipid metabolism | 5.141863e-01 | 0.289 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.173274e-01 | 0.286 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.179946e-01 | 0.286 |
R-HSA-6794362 | Protein-protein interactions at synapses | 5.179946e-01 | 0.286 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.197425e-01 | 0.284 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.255225e-01 | 0.279 |
R-HSA-1614635 | Sulfur amino acid metabolism | 5.255225e-01 | 0.279 |
R-HSA-438064 | Post NMDA receptor activation events | 5.292426e-01 | 0.276 |
R-HSA-73884 | Base Excision Repair | 5.402302e-01 | 0.267 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.438359e-01 | 0.265 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.438359e-01 | 0.265 |
R-HSA-1474290 | Collagen formation | 5.579802e-01 | 0.253 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.683021e-01 | 0.245 |
R-HSA-6807878 | COPI-mediated anterograde transport | 5.683021e-01 | 0.245 |
R-HSA-2262752 | Cellular responses to stress | 5.701998e-01 | 0.244 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.716893e-01 | 0.243 |
R-HSA-3214847 | HATs acetylate histones | 5.783849e-01 | 0.238 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.783849e-01 | 0.238 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 5.796864e-01 | 0.237 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.882340e-01 | 0.230 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.882340e-01 | 0.230 |
R-HSA-9842860 | Regulation of endogenous retroelements | 5.882340e-01 | 0.230 |
R-HSA-72312 | rRNA processing | 5.884130e-01 | 0.230 |
R-HSA-5696398 | Nucleotide Excision Repair | 6.010119e-01 | 0.221 |
R-HSA-157118 | Signaling by NOTCH | 6.054655e-01 | 0.218 |
R-HSA-211000 | Gene Silencing by RNA | 6.072525e-01 | 0.217 |
R-HSA-2672351 | Stimuli-sensing channels | 6.103364e-01 | 0.214 |
R-HSA-202403 | TCR signaling | 6.164323e-01 | 0.210 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.283418e-01 | 0.202 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.341582e-01 | 0.198 |
R-HSA-5688426 | Deubiquitination | 6.360000e-01 | 0.197 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.370325e-01 | 0.196 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.483072e-01 | 0.188 |
R-HSA-73886 | Chromosome Maintenance | 6.538135e-01 | 0.185 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.592343e-01 | 0.181 |
R-HSA-162909 | Host Interactions of HIV factors | 6.619131e-01 | 0.179 |
R-HSA-194138 | Signaling by VEGF | 6.672081e-01 | 0.176 |
R-HSA-446728 | Cell junction organization | 6.792140e-01 | 0.168 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.809955e-01 | 0.167 |
R-HSA-1474165 | Reproduction | 6.826044e-01 | 0.166 |
R-HSA-9843745 | Adipogenesis | 6.851008e-01 | 0.164 |
R-HSA-72766 | Translation | 6.869842e-01 | 0.163 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.875777e-01 | 0.163 |
R-HSA-9018519 | Estrogen-dependent gene expression | 6.996755e-01 | 0.155 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.113085e-01 | 0.148 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.158354e-01 | 0.145 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 7.158354e-01 | 0.145 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 7.180725e-01 | 0.144 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.230176e-01 | 0.141 |
R-HSA-9856651 | MITF-M-dependent gene expression | 7.332499e-01 | 0.135 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.353508e-01 | 0.134 |
R-HSA-168249 | Innate Immune System | 7.380948e-01 | 0.132 |
R-HSA-9609507 | Protein localization | 7.395037e-01 | 0.131 |
R-HSA-112316 | Neuronal System | 7.397997e-01 | 0.131 |
R-HSA-1500931 | Cell-Cell communication | 7.414312e-01 | 0.130 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.415558e-01 | 0.130 |
R-HSA-73887 | Death Receptor Signaling | 7.415558e-01 | 0.130 |
R-HSA-1989781 | PPARA activates gene expression | 7.435918e-01 | 0.129 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.476164e-01 | 0.126 |
R-HSA-162587 | HIV Life Cycle | 7.476164e-01 | 0.126 |
R-HSA-449147 | Signaling by Interleukins | 7.483359e-01 | 0.126 |
R-HSA-112315 | Transmission across Chemical Synapses | 7.517091e-01 | 0.124 |
R-HSA-109582 | Hemostasis | 7.600486e-01 | 0.119 |
R-HSA-1474244 | Extracellular matrix organization | 7.630269e-01 | 0.117 |
R-HSA-199991 | Membrane Trafficking | 7.724067e-01 | 0.112 |
R-HSA-418555 | G alpha (s) signalling events | 7.758679e-01 | 0.110 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.776357e-01 | 0.109 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.793896e-01 | 0.108 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.793896e-01 | 0.108 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.811298e-01 | 0.107 |
R-HSA-9694516 | SARS-CoV-2 Infection | 7.868805e-01 | 0.104 |
R-HSA-74160 | Gene expression (Transcription) | 7.942022e-01 | 0.100 |
R-HSA-73894 | DNA Repair | 8.004055e-01 | 0.097 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 8.039610e-01 | 0.095 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 8.132093e-01 | 0.090 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.161485e-01 | 0.088 |
R-HSA-389948 | Co-inhibition by PD-1 | 8.218898e-01 | 0.085 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.218898e-01 | 0.085 |
R-HSA-72172 | mRNA Splicing | 8.288169e-01 | 0.082 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.393485e-01 | 0.076 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.406189e-01 | 0.075 |
R-HSA-418990 | Adherens junctions interactions | 8.468229e-01 | 0.072 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.562548e-01 | 0.067 |
R-HSA-162906 | HIV Infection | 8.573925e-01 | 0.067 |
R-HSA-446203 | Asparagine N-linked glycosylation | 8.642042e-01 | 0.063 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 8.645129e-01 | 0.063 |
R-HSA-8939211 | ESR-mediated signaling | 8.682896e-01 | 0.061 |
R-HSA-156580 | Phase II - Conjugation of compounds | 8.703677e-01 | 0.060 |
R-HSA-73857 | RNA Polymerase II Transcription | 8.742281e-01 | 0.058 |
R-HSA-421270 | Cell-cell junction organization | 8.821709e-01 | 0.054 |
R-HSA-6798695 | Neutrophil degranulation | 8.910518e-01 | 0.050 |
R-HSA-9824446 | Viral Infection Pathways | 8.920954e-01 | 0.050 |
R-HSA-5653656 | Vesicle-mediated transport | 8.935153e-01 | 0.049 |
R-HSA-416476 | G alpha (q) signalling events | 8.937567e-01 | 0.049 |
R-HSA-9711123 | Cellular response to chemical stress | 8.970888e-01 | 0.047 |
R-HSA-168256 | Immune System | 8.993850e-01 | 0.046 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 9.018934e-01 | 0.045 |
R-HSA-211945 | Phase I - Functionalization of compounds | 9.049721e-01 | 0.043 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.079550e-01 | 0.042 |
R-HSA-211859 | Biological oxidations | 9.288351e-01 | 0.032 |
R-HSA-212436 | Generic Transcription Pathway | 9.331670e-01 | 0.030 |
R-HSA-9679506 | SARS-CoV Infections | 9.423660e-01 | 0.026 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.592981e-01 | 0.018 |
R-HSA-8978868 | Fatty acid metabolism | 9.664343e-01 | 0.015 |
R-HSA-5668914 | Diseases of metabolism | 9.714220e-01 | 0.013 |
R-HSA-556833 | Metabolism of lipids | 9.814725e-01 | 0.008 |
R-HSA-5663205 | Infectious disease | 9.939940e-01 | 0.003 |
R-HSA-1430728 | Metabolism | 9.959017e-01 | 0.002 |
R-HSA-1643685 | Disease | 9.966132e-01 | 0.001 |
R-HSA-382551 | Transport of small molecules | 9.971440e-01 | 0.001 |
R-HSA-597592 | Post-translational protein modification | 9.976820e-01 | 0.001 |
R-HSA-392499 | Metabolism of proteins | 9.992357e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CDK18 |
0.854 | 0.811 | 1 | 0.874 |
CDK19 |
0.853 | 0.785 | 1 | 0.871 |
CDK17 |
0.853 | 0.823 | 1 | 0.890 |
P38G |
0.850 | 0.834 | 1 | 0.899 |
HIPK2 |
0.849 | 0.739 | 1 | 0.861 |
CDK7 |
0.849 | 0.789 | 1 | 0.845 |
CDK8 |
0.849 | 0.786 | 1 | 0.843 |
JNK2 |
0.849 | 0.843 | 1 | 0.882 |
ERK1 |
0.845 | 0.802 | 1 | 0.864 |
CDK3 |
0.844 | 0.729 | 1 | 0.886 |
KIS |
0.843 | 0.701 | 1 | 0.824 |
CDK13 |
0.842 | 0.783 | 1 | 0.863 |
CDK5 |
0.841 | 0.770 | 1 | 0.817 |
CDK12 |
0.840 | 0.787 | 1 | 0.880 |
P38B |
0.840 | 0.803 | 1 | 0.843 |
JNK3 |
0.839 | 0.829 | 1 | 0.857 |
CDK16 |
0.839 | 0.778 | 1 | 0.883 |
P38D |
0.839 | 0.804 | 1 | 0.906 |
DYRK2 |
0.837 | 0.717 | 1 | 0.789 |
CDK1 |
0.837 | 0.775 | 1 | 0.851 |
CDK14 |
0.834 | 0.775 | 1 | 0.850 |
CDK9 |
0.833 | 0.770 | 1 | 0.860 |
P38A |
0.832 | 0.776 | 1 | 0.792 |
DYRK4 |
0.832 | 0.724 | 1 | 0.869 |
ERK2 |
0.832 | 0.795 | 1 | 0.820 |
DYRK1B |
0.830 | 0.701 | 1 | 0.829 |
HIPK1 |
0.829 | 0.666 | 1 | 0.779 |
HIPK4 |
0.826 | 0.473 | 1 | 0.605 |
CDK10 |
0.824 | 0.715 | 1 | 0.860 |
DYRK1A |
0.824 | 0.598 | 1 | 0.765 |
NLK |
0.823 | 0.701 | 1 | 0.619 |
HIPK3 |
0.823 | 0.649 | 1 | 0.762 |
CDK4 |
0.822 | 0.764 | 1 | 0.887 |
CDK6 |
0.821 | 0.743 | 1 | 0.869 |
CLK3 |
0.819 | 0.466 | 1 | 0.565 |
ERK5 |
0.818 | 0.422 | 1 | 0.518 |
JNK1 |
0.818 | 0.738 | 1 | 0.873 |
MAK |
0.813 | 0.526 | -2 | 0.830 |
CDK2 |
0.813 | 0.604 | 1 | 0.746 |
DYRK3 |
0.811 | 0.528 | 1 | 0.744 |
SRPK1 |
0.811 | 0.326 | -3 | 0.715 |
ICK |
0.807 | 0.380 | -3 | 0.799 |
CLK1 |
0.802 | 0.387 | -3 | 0.687 |
CDKL5 |
0.802 | 0.190 | -3 | 0.755 |
MTOR |
0.800 | 0.205 | 1 | 0.424 |
CDKL1 |
0.798 | 0.166 | -3 | 0.760 |
CLK4 |
0.797 | 0.354 | -3 | 0.704 |
PRP4 |
0.797 | 0.445 | -3 | 0.738 |
SRPK2 |
0.796 | 0.251 | -3 | 0.638 |
COT |
0.794 | -0.029 | 2 | 0.791 |
MOK |
0.793 | 0.456 | 1 | 0.663 |
TBK1 |
0.793 | -0.095 | 1 | 0.251 |
MOS |
0.791 | 0.030 | 1 | 0.287 |
CLK2 |
0.790 | 0.368 | -3 | 0.695 |
PRKD1 |
0.789 | 0.017 | -3 | 0.792 |
IKKE |
0.789 | -0.105 | 1 | 0.253 |
ERK7 |
0.788 | 0.302 | 2 | 0.559 |
ULK2 |
0.788 | -0.106 | 2 | 0.776 |
PRPK |
0.787 | -0.065 | -1 | 0.864 |
CDC7 |
0.787 | -0.091 | 1 | 0.235 |
GCN2 |
0.785 | -0.162 | 2 | 0.783 |
NDR2 |
0.784 | -0.019 | -3 | 0.790 |
RAF1 |
0.784 | -0.145 | 1 | 0.265 |
SKMLCK |
0.784 | 0.010 | -2 | 0.860 |
SRPK3 |
0.783 | 0.205 | -3 | 0.682 |
PDHK4 |
0.783 | -0.124 | 1 | 0.321 |
NEK6 |
0.783 | -0.047 | -2 | 0.791 |
WNK1 |
0.782 | -0.049 | -2 | 0.877 |
DSTYK |
0.782 | -0.087 | 2 | 0.821 |
PKN3 |
0.782 | -0.024 | -3 | 0.775 |
RIPK3 |
0.782 | -0.069 | 3 | 0.838 |
PDHK1 |
0.781 | -0.138 | 1 | 0.310 |
CHAK2 |
0.781 | -0.018 | -1 | 0.896 |
BMPR2 |
0.780 | -0.122 | -2 | 0.856 |
ATR |
0.780 | -0.058 | 1 | 0.284 |
PKCD |
0.780 | 0.007 | 2 | 0.727 |
CAMK1B |
0.780 | -0.040 | -3 | 0.798 |
PIM3 |
0.780 | -0.034 | -3 | 0.785 |
ULK1 |
0.779 | -0.113 | -3 | 0.791 |
MST4 |
0.779 | -0.028 | 2 | 0.746 |
PRKD2 |
0.779 | 0.005 | -3 | 0.723 |
IKKB |
0.778 | -0.149 | -2 | 0.723 |
MNK2 |
0.778 | 0.015 | -2 | 0.797 |
NDR1 |
0.778 | -0.054 | -3 | 0.777 |
CAMLCK |
0.778 | 0.003 | -2 | 0.852 |
BCKDK |
0.777 | -0.108 | -1 | 0.856 |
NIK |
0.777 | -0.045 | -3 | 0.813 |
MLK2 |
0.777 | -0.031 | 2 | 0.767 |
IRE1 |
0.776 | -0.059 | 1 | 0.241 |
AURC |
0.776 | 0.041 | -2 | 0.685 |
NEK7 |
0.776 | -0.145 | -3 | 0.798 |
WNK3 |
0.775 | -0.166 | 1 | 0.261 |
TGFBR2 |
0.775 | -0.096 | -2 | 0.746 |
NUAK2 |
0.775 | -0.017 | -3 | 0.762 |
P90RSK |
0.775 | -0.014 | -3 | 0.743 |
RSK3 |
0.774 | -0.020 | -3 | 0.723 |
MPSK1 |
0.774 | 0.101 | 1 | 0.319 |
PAK3 |
0.774 | -0.030 | -2 | 0.807 |
NIM1 |
0.774 | -0.046 | 3 | 0.832 |
RIPK1 |
0.773 | -0.133 | 1 | 0.237 |
HUNK |
0.773 | -0.116 | 2 | 0.790 |
MLK1 |
0.773 | -0.119 | 2 | 0.766 |
PKN2 |
0.773 | -0.059 | -3 | 0.759 |
DAPK2 |
0.773 | -0.035 | -3 | 0.806 |
MAPKAPK3 |
0.773 | -0.053 | -3 | 0.723 |
LATS2 |
0.772 | -0.048 | -5 | 0.639 |
PRKD3 |
0.772 | -0.006 | -3 | 0.693 |
PKCA |
0.771 | 0.013 | 2 | 0.679 |
PHKG1 |
0.771 | -0.040 | -3 | 0.756 |
MARK4 |
0.771 | -0.069 | 4 | 0.814 |
PAK1 |
0.771 | -0.017 | -2 | 0.812 |
TSSK1 |
0.771 | -0.051 | -3 | 0.798 |
CAMK2G |
0.771 | -0.103 | 2 | 0.771 |
NEK9 |
0.771 | -0.132 | 2 | 0.790 |
PLK4 |
0.771 | -0.050 | 2 | 0.677 |
RSK2 |
0.771 | -0.021 | -3 | 0.728 |
IKKA |
0.770 | -0.072 | -2 | 0.706 |
PINK1 |
0.770 | 0.169 | 1 | 0.451 |
MLK3 |
0.770 | -0.021 | 2 | 0.690 |
AMPKA1 |
0.770 | -0.078 | -3 | 0.776 |
PKCZ |
0.770 | 0.000 | 2 | 0.748 |
IRE2 |
0.769 | -0.066 | 2 | 0.738 |
TSSK2 |
0.769 | -0.077 | -5 | 0.752 |
PKCG |
0.769 | -0.009 | 2 | 0.688 |
GRK1 |
0.769 | -0.015 | -2 | 0.780 |
PAK6 |
0.769 | -0.000 | -2 | 0.727 |
MASTL |
0.769 | -0.142 | -2 | 0.790 |
PKCB |
0.768 | -0.003 | 2 | 0.685 |
MAPKAPK2 |
0.768 | -0.021 | -3 | 0.689 |
CAMK2D |
0.768 | -0.077 | -3 | 0.779 |
PKACG |
0.768 | -0.031 | -2 | 0.748 |
PIM1 |
0.768 | 0.002 | -3 | 0.714 |
ANKRD3 |
0.768 | -0.123 | 1 | 0.272 |
NEK2 |
0.768 | -0.073 | 2 | 0.785 |
LATS1 |
0.768 | 0.018 | -3 | 0.825 |
DNAPK |
0.767 | -0.029 | 1 | 0.286 |
MNK1 |
0.767 | 0.001 | -2 | 0.809 |
ATM |
0.767 | -0.067 | 1 | 0.245 |
MELK |
0.766 | -0.068 | -3 | 0.739 |
VRK2 |
0.766 | 0.067 | 1 | 0.348 |
FAM20C |
0.766 | 0.049 | 2 | 0.666 |
P70S6KB |
0.765 | -0.038 | -3 | 0.734 |
AMPKA2 |
0.765 | -0.062 | -3 | 0.749 |
NUAK1 |
0.765 | -0.050 | -3 | 0.727 |
PKR |
0.765 | -0.046 | 1 | 0.268 |
CHAK1 |
0.765 | -0.097 | 2 | 0.762 |
TTBK2 |
0.764 | -0.161 | 2 | 0.692 |
IRAK4 |
0.764 | -0.051 | 1 | 0.234 |
GRK5 |
0.764 | -0.167 | -3 | 0.774 |
SGK3 |
0.764 | 0.001 | -3 | 0.690 |
AURB |
0.763 | -0.002 | -2 | 0.676 |
PKG2 |
0.763 | 0.000 | -2 | 0.697 |
MSK2 |
0.762 | -0.037 | -3 | 0.694 |
DLK |
0.762 | -0.186 | 1 | 0.255 |
PKCH |
0.762 | -0.037 | 2 | 0.700 |
PAK2 |
0.761 | -0.058 | -2 | 0.792 |
MLK4 |
0.761 | -0.065 | 2 | 0.697 |
TGFBR1 |
0.761 | -0.058 | -2 | 0.762 |
YSK4 |
0.760 | -0.119 | 1 | 0.248 |
BMPR1B |
0.760 | -0.056 | 1 | 0.197 |
CAMK4 |
0.760 | -0.129 | -3 | 0.737 |
AKT2 |
0.760 | 0.021 | -3 | 0.629 |
RSK4 |
0.760 | -0.012 | -3 | 0.705 |
GRK7 |
0.759 | -0.001 | 1 | 0.253 |
SNRK |
0.759 | -0.116 | 2 | 0.728 |
PKCT |
0.759 | -0.025 | 2 | 0.698 |
SMG1 |
0.759 | -0.079 | 1 | 0.269 |
ALK4 |
0.759 | -0.082 | -2 | 0.787 |
QSK |
0.758 | -0.057 | 4 | 0.801 |
PKACB |
0.758 | 0.012 | -2 | 0.691 |
GRK6 |
0.758 | -0.149 | 1 | 0.233 |
WNK4 |
0.758 | -0.091 | -2 | 0.852 |
GRK4 |
0.757 | -0.164 | -2 | 0.794 |
MEKK1 |
0.757 | -0.099 | 1 | 0.269 |
QIK |
0.756 | -0.120 | -3 | 0.755 |
TLK2 |
0.756 | -0.108 | 1 | 0.242 |
SSTK |
0.756 | -0.025 | 4 | 0.812 |
PLK1 |
0.756 | -0.137 | -2 | 0.745 |
MSK1 |
0.755 | -0.025 | -3 | 0.692 |
MEK1 |
0.755 | -0.148 | 2 | 0.801 |
DCAMKL1 |
0.755 | -0.043 | -3 | 0.718 |
BRSK2 |
0.755 | -0.103 | -3 | 0.742 |
MYLK4 |
0.755 | -0.043 | -2 | 0.788 |
SIK |
0.754 | -0.068 | -3 | 0.694 |
ZAK |
0.754 | -0.118 | 1 | 0.246 |
MEKK2 |
0.754 | -0.078 | 2 | 0.773 |
CAMK2B |
0.754 | -0.059 | 2 | 0.734 |
CAMK2A |
0.753 | -0.037 | 2 | 0.740 |
PERK |
0.753 | -0.129 | -2 | 0.795 |
AKT1 |
0.753 | 0.003 | -3 | 0.643 |
NEK5 |
0.753 | -0.090 | 1 | 0.250 |
BRAF |
0.753 | -0.089 | -4 | 0.800 |
PAK5 |
0.753 | -0.024 | -2 | 0.666 |
MEK5 |
0.752 | -0.132 | 2 | 0.793 |
PAK4 |
0.752 | -0.006 | -2 | 0.676 |
PHKG2 |
0.752 | -0.080 | -3 | 0.718 |
BRSK1 |
0.752 | -0.085 | -3 | 0.726 |
HRI |
0.752 | -0.154 | -2 | 0.811 |
MAPKAPK5 |
0.752 | -0.086 | -3 | 0.666 |
CHK1 |
0.752 | -0.098 | -3 | 0.763 |
DCAMKL2 |
0.751 | -0.054 | -3 | 0.743 |
PIM2 |
0.751 | -0.015 | -3 | 0.687 |
MST3 |
0.751 | -0.042 | 2 | 0.764 |
PKCI |
0.751 | -0.016 | 2 | 0.723 |
AURA |
0.750 | -0.030 | -2 | 0.646 |
LKB1 |
0.750 | -0.004 | -3 | 0.777 |
ALK2 |
0.750 | -0.088 | -2 | 0.767 |
MAP3K15 |
0.750 | -0.033 | 1 | 0.261 |
ACVR2A |
0.750 | -0.114 | -2 | 0.744 |
ACVR2B |
0.750 | -0.111 | -2 | 0.752 |
GSK3A |
0.749 | 0.148 | 4 | 0.331 |
PDK1 |
0.748 | -0.040 | 1 | 0.291 |
MARK3 |
0.748 | -0.076 | 4 | 0.743 |
TAO3 |
0.748 | -0.047 | 1 | 0.283 |
SMMLCK |
0.748 | -0.037 | -3 | 0.756 |
MARK2 |
0.747 | -0.090 | 4 | 0.711 |
PKN1 |
0.747 | -0.028 | -3 | 0.659 |
CAMK1G |
0.747 | -0.073 | -3 | 0.700 |
PRKX |
0.747 | 0.014 | -3 | 0.608 |
MEKK3 |
0.747 | -0.165 | 1 | 0.256 |
TLK1 |
0.747 | -0.141 | -2 | 0.780 |
AKT3 |
0.747 | 0.025 | -3 | 0.580 |
DRAK1 |
0.746 | -0.147 | 1 | 0.187 |
NEK11 |
0.746 | -0.110 | 1 | 0.279 |
BUB1 |
0.746 | 0.018 | -5 | 0.664 |
PKACA |
0.746 | -0.003 | -2 | 0.651 |
SBK |
0.746 | 0.097 | -3 | 0.528 |
MEKK6 |
0.745 | -0.067 | 1 | 0.261 |
NEK4 |
0.745 | -0.100 | 1 | 0.251 |
PLK3 |
0.745 | -0.139 | 2 | 0.757 |
PKCE |
0.744 | -0.002 | 2 | 0.681 |
NEK8 |
0.744 | -0.123 | 2 | 0.792 |
IRAK1 |
0.743 | -0.172 | -1 | 0.815 |
HASPIN |
0.743 | 0.072 | -1 | 0.827 |
HGK |
0.743 | -0.045 | 3 | 0.877 |
TAO2 |
0.742 | -0.068 | 2 | 0.785 |
TTBK1 |
0.742 | -0.156 | 2 | 0.623 |
MARK1 |
0.741 | -0.115 | 4 | 0.775 |
TNIK |
0.741 | -0.015 | 3 | 0.870 |
BMPR1A |
0.741 | -0.085 | 1 | 0.186 |
MINK |
0.740 | -0.075 | 1 | 0.257 |
GCK |
0.740 | -0.064 | 1 | 0.273 |
P70S6K |
0.740 | -0.066 | -3 | 0.650 |
GRK2 |
0.740 | -0.116 | -2 | 0.685 |
PBK |
0.740 | -0.012 | 1 | 0.282 |
PDHK3_TYR |
0.739 | 0.178 | 4 | 0.885 |
CAMKK1 |
0.739 | -0.145 | -2 | 0.748 |
GAK |
0.739 | -0.053 | 1 | 0.304 |
LRRK2 |
0.739 | -0.008 | 2 | 0.822 |
SGK1 |
0.738 | 0.023 | -3 | 0.558 |
KHS1 |
0.738 | -0.026 | 1 | 0.276 |
CAMK1D |
0.737 | -0.057 | -3 | 0.619 |
LOK |
0.737 | -0.057 | -2 | 0.762 |
NEK1 |
0.737 | -0.109 | 1 | 0.239 |
MRCKB |
0.737 | -0.009 | -3 | 0.668 |
LIMK2_TYR |
0.736 | 0.144 | -3 | 0.839 |
RIPK2 |
0.736 | -0.163 | 1 | 0.232 |
CAMKK2 |
0.736 | -0.118 | -2 | 0.754 |
ROCK2 |
0.735 | -0.008 | -3 | 0.716 |
HPK1 |
0.734 | -0.074 | 1 | 0.275 |
CK1E |
0.734 | -0.072 | -3 | 0.422 |
NEK3 |
0.734 | -0.081 | 1 | 0.268 |
CHK2 |
0.734 | -0.040 | -3 | 0.578 |
DAPK3 |
0.734 | -0.046 | -3 | 0.733 |
CAMK1A |
0.734 | -0.035 | -3 | 0.608 |
MST2 |
0.733 | -0.124 | 1 | 0.255 |
YSK1 |
0.733 | -0.078 | 2 | 0.760 |
TESK1_TYR |
0.733 | 0.065 | 3 | 0.896 |
EEF2K |
0.733 | -0.079 | 3 | 0.838 |
KHS2 |
0.733 | -0.021 | 1 | 0.285 |
GSK3B |
0.733 | -0.003 | 4 | 0.324 |
BIKE |
0.732 | -0.003 | 1 | 0.289 |
PKMYT1_TYR |
0.732 | 0.135 | 3 | 0.888 |
PASK |
0.732 | -0.093 | -3 | 0.797 |
MRCKA |
0.730 | -0.036 | -3 | 0.688 |
PKG1 |
0.729 | -0.027 | -2 | 0.627 |
CK1G1 |
0.729 | -0.101 | -3 | 0.447 |
SLK |
0.729 | -0.062 | -2 | 0.699 |
TAK1 |
0.729 | -0.164 | 1 | 0.256 |
VRK1 |
0.729 | -0.152 | 2 | 0.799 |
AAK1 |
0.729 | 0.028 | 1 | 0.285 |
ASK1 |
0.727 | -0.068 | 1 | 0.260 |
PDHK4_TYR |
0.727 | 0.047 | 2 | 0.821 |
CSF1R |
0.727 | -0.005 | 3 | 0.876 |
MEK2 |
0.726 | -0.170 | 2 | 0.784 |
STK33 |
0.726 | -0.123 | 2 | 0.611 |
DMPK1 |
0.726 | 0.006 | -3 | 0.688 |
CK1D |
0.725 | -0.058 | -3 | 0.373 |
MAP2K7_TYR |
0.725 | -0.053 | 2 | 0.829 |
MST1 |
0.725 | -0.141 | 1 | 0.248 |
MAP2K4_TYR |
0.725 | -0.002 | -1 | 0.885 |
MST1R |
0.725 | -0.035 | 3 | 0.879 |
LIMK1_TYR |
0.725 | 0.026 | 2 | 0.823 |
RET |
0.725 | -0.077 | 1 | 0.278 |
TNK1 |
0.724 | 0.025 | 3 | 0.859 |
CRIK |
0.724 | -0.010 | -3 | 0.657 |
JAK2 |
0.724 | -0.053 | 1 | 0.292 |
MAP2K6_TYR |
0.724 | 0.015 | -1 | 0.891 |
ROS1 |
0.723 | -0.053 | 3 | 0.860 |
DAPK1 |
0.722 | -0.066 | -3 | 0.709 |
ROCK1 |
0.722 | -0.024 | -3 | 0.680 |
TYRO3 |
0.721 | -0.078 | 3 | 0.876 |
CK2A2 |
0.721 | -0.077 | 1 | 0.160 |
TTK |
0.721 | -0.060 | -2 | 0.772 |
EPHA6 |
0.721 | -0.031 | -1 | 0.854 |
OSR1 |
0.720 | -0.062 | 2 | 0.750 |
GRK3 |
0.720 | -0.127 | -2 | 0.634 |
PINK1_TYR |
0.720 | -0.127 | 1 | 0.296 |
MYO3B |
0.720 | -0.058 | 2 | 0.771 |
TYK2 |
0.719 | -0.147 | 1 | 0.272 |
BMPR2_TYR |
0.719 | -0.003 | -1 | 0.883 |
JAK3 |
0.719 | -0.061 | 1 | 0.259 |
TAO1 |
0.719 | -0.083 | 1 | 0.259 |
CK1A2 |
0.719 | -0.084 | -3 | 0.366 |
FGFR1 |
0.719 | 0.023 | 3 | 0.852 |
TNK2 |
0.718 | -0.019 | 3 | 0.839 |
PDHK1_TYR |
0.718 | -0.075 | -1 | 0.888 |
JAK1 |
0.717 | -0.042 | 1 | 0.262 |
FGFR2 |
0.717 | 0.005 | 3 | 0.859 |
TEK |
0.717 | 0.029 | 3 | 0.839 |
TNNI3K_TYR |
0.717 | -0.013 | 1 | 0.287 |
MYO3A |
0.717 | -0.074 | 1 | 0.265 |
NEK10_TYR |
0.717 | -0.077 | 1 | 0.268 |
EPHB4 |
0.716 | -0.071 | -1 | 0.824 |
PLK2 |
0.715 | -0.112 | -3 | 0.733 |
DDR1 |
0.715 | -0.081 | 4 | 0.824 |
YES1 |
0.714 | -0.057 | -1 | 0.813 |
TXK |
0.714 | -0.042 | 1 | 0.198 |
KDR |
0.713 | -0.032 | 3 | 0.849 |
LCK |
0.713 | -0.044 | -1 | 0.802 |
PDGFRB |
0.713 | -0.120 | 3 | 0.882 |
ABL2 |
0.712 | -0.088 | -1 | 0.799 |
INSRR |
0.711 | -0.082 | 3 | 0.838 |
KIT |
0.711 | -0.080 | 3 | 0.877 |
CK2A1 |
0.711 | -0.090 | 1 | 0.148 |
AXL |
0.711 | -0.093 | 3 | 0.864 |
FLT3 |
0.710 | -0.121 | 3 | 0.872 |
HCK |
0.710 | -0.091 | -1 | 0.802 |
BLK |
0.710 | -0.033 | -1 | 0.805 |
ALPHAK3 |
0.708 | -0.086 | -1 | 0.778 |
ABL1 |
0.708 | -0.103 | -1 | 0.791 |
STLK3 |
0.708 | -0.131 | 1 | 0.232 |
MET |
0.708 | -0.065 | 3 | 0.862 |
PDGFRA |
0.708 | -0.140 | 3 | 0.880 |
MERTK |
0.707 | -0.089 | 3 | 0.853 |
FGR |
0.707 | -0.146 | 1 | 0.230 |
FGFR3 |
0.707 | -0.017 | 3 | 0.843 |
ITK |
0.706 | -0.109 | -1 | 0.794 |
FER |
0.706 | -0.158 | 1 | 0.236 |
DDR2 |
0.705 | 0.002 | 3 | 0.822 |
EPHA1 |
0.704 | -0.085 | 3 | 0.856 |
EPHB3 |
0.704 | -0.120 | -1 | 0.804 |
EPHA4 |
0.704 | -0.081 | 2 | 0.738 |
EPHB1 |
0.703 | -0.136 | 1 | 0.212 |
SRMS |
0.703 | -0.137 | 1 | 0.208 |
EPHB2 |
0.703 | -0.110 | -1 | 0.796 |
ALK |
0.702 | -0.112 | 3 | 0.813 |
FYN |
0.702 | -0.037 | -1 | 0.774 |
EPHA7 |
0.701 | -0.083 | 2 | 0.756 |
BMX |
0.700 | -0.086 | -1 | 0.703 |
FRK |
0.700 | -0.101 | -1 | 0.809 |
FLT4 |
0.699 | -0.102 | 3 | 0.835 |
INSR |
0.699 | -0.110 | 3 | 0.822 |
TEC |
0.698 | -0.123 | -1 | 0.722 |
WEE1_TYR |
0.698 | -0.090 | -1 | 0.772 |
LYN |
0.697 | -0.087 | 3 | 0.814 |
BTK |
0.697 | -0.176 | -1 | 0.761 |
LTK |
0.697 | -0.131 | 3 | 0.827 |
ERBB2 |
0.697 | -0.133 | 1 | 0.238 |
NTRK1 |
0.696 | -0.163 | -1 | 0.812 |
NTRK2 |
0.696 | -0.156 | 3 | 0.839 |
FLT1 |
0.695 | -0.115 | -1 | 0.827 |
YANK3 |
0.694 | -0.090 | 2 | 0.378 |
NTRK3 |
0.694 | -0.110 | -1 | 0.757 |
EGFR |
0.693 | -0.086 | 1 | 0.197 |
SRC |
0.693 | -0.080 | -1 | 0.768 |
EPHA3 |
0.693 | -0.123 | 2 | 0.726 |
FGFR4 |
0.691 | -0.076 | -1 | 0.750 |
PTK2B |
0.691 | -0.101 | -1 | 0.758 |
EPHA8 |
0.690 | -0.091 | -1 | 0.790 |
PTK6 |
0.689 | -0.197 | -1 | 0.724 |
MUSK |
0.689 | -0.112 | 1 | 0.185 |
MATK |
0.688 | -0.099 | -1 | 0.733 |
EPHA5 |
0.688 | -0.116 | 2 | 0.744 |
CSK |
0.687 | -0.130 | 2 | 0.751 |
ERBB4 |
0.684 | -0.065 | 1 | 0.190 |
CK1A |
0.682 | -0.106 | -3 | 0.288 |
IGF1R |
0.682 | -0.118 | 3 | 0.770 |
EPHA2 |
0.681 | -0.099 | -1 | 0.759 |
PTK2 |
0.679 | -0.063 | -1 | 0.786 |
SYK |
0.675 | -0.089 | -1 | 0.757 |
ZAP70 |
0.668 | -0.059 | -1 | 0.700 |
FES |
0.668 | -0.124 | -1 | 0.683 |
CK1G3 |
0.660 | -0.114 | -3 | 0.244 |
YANK2 |
0.658 | -0.114 | 2 | 0.393 |
CK1G2 |
0.636 | -0.116 | -3 | 0.347 |