Motif 339 (n=283)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S497 | ochoa | Golgin A8 family member Q | None |
| A7E2V4 | ZSWIM8 | S567 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| A7KAX9 | ARHGAP32 | S1796 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A8MVW0 | FAM171A2 | S424 | ochoa | Protein FAM171A2 | None |
| A8MVW0 | FAM171A2 | S664 | ochoa | Protein FAM171A2 | None |
| B7ZBB8 | PPP1R3G | S86 | ochoa | Protein phosphatase 1 regulatory subunit 3G | Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity). {ECO:0000250}. |
| C9JI98 | TMEM238 | S124 | ochoa | Transmembrane protein 238 | None |
| H3BSY2 | GOLGA8M | S497 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S496 | ochoa | Golgin subfamily A member 8R | None |
| O00170 | AIP | S131 | psp | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O00213 | APBB1 | S610 | psp | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) | Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed:36250347). {ECO:0000250|UniProtKB:Q9QXJ1, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:36250347}. |
| O00299 | CLIC1 | S211 | ochoa | Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:10874038, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9139710}. |
| O00443 | PIK3C2A | S338 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O14490 | DLGAP1 | S932 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14492 | SH2B2 | S598 | ochoa | SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}. |
| O14654 | IRS4 | S427 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14681 | EI24 | S56 | ochoa | Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) | Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}. |
| O14813 | PHOX2A | S153 | psp | Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) | May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. |
| O14966 | RAB29 | S72 | psp | Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) | The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815, PubMed:38127736). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection (PubMed:22042847). {ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736}. |
| O15015 | ZNF646 | S1442 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
| O15018 | PDZD2 | S920 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15020 | SPTBN2 | S771 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O15027 | SEC16A | S1810 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15037 | KHNYN | S291 | ochoa | Protein KHNYN (KH and NYN domain-containing protein) | None |
| O15063 | GARRE1 | S673 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
| O15068 | MCF2L | S609 | ochoa | Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) | Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250|UniProtKB:Q63406, ECO:0000269|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269|PubMed:15157669}. |
| O15151 | MDM4 | S367 | ochoa|psp | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O15294 | OGT | S20 | ochoa|psp | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:12150998, PubMed:15361863, PubMed:19451179, PubMed:20018868, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27713473, PubMed:37541260, PubMed:37962578). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (PubMed:19451179, PubMed:20200153, PubMed:21285374, PubMed:22923583, PubMed:23353889, PubMed:24474760, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27527864, PubMed:30699359, PubMed:34074792, PubMed:34667079, PubMed:37541260, PubMed:37962578). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (PubMed:26678539). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28302723, PubMed:28584052). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (PubMed:27527864). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (PubMed:30699359, PubMed:37541260). {ECO:0000250|UniProtKB:P56558, ECO:0000250|UniProtKB:Q8CGY8, ECO:0000269|PubMed:12150998, ECO:0000269|PubMed:15361863, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20018868, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:21240259, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:22121020, ECO:0000269|PubMed:22923583, ECO:0000269|PubMed:23103939, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:26237509, ECO:0000269|PubMed:26369908, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28302723, ECO:0000269|PubMed:28584052, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:34667079, ECO:0000269|PubMed:37541260, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 2]: The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line. {ECO:0000269|PubMed:20824293}.; FUNCTION: [Isoform 4]: Has N-acetylglucosaminyltransferase activity: glycosylates proteins, such as HNRNPU, NEUROD1, NUP62 and PDCD6IP (PubMed:31527085). Displays specific substrate selectivity compared to other isoforms (PubMed:31527085). {ECO:0000269|PubMed:31527085}. |
| O43290 | SART1 | S84 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O60784 | TOM1 | S405 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75122 | CLASP2 | S22 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75128 | COBL | S962 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75151 | PHF2 | S1056 | ochoa|psp | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75427 | LRCH4 | S432 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O94804 | STK10 | S454 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94921 | CDK14 | S78 | ochoa | Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}. |
| O95810 | CAVIN2 | S51 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| O96013 | PAK4 | S181 | ochoa|psp | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P00488 | F13A1 | S688 | ochoa | Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain) | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. {ECO:0000269|PubMed:27363989}. |
| P04075 | ALDOA | S46 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P04406 | GAPDH | S83 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P04899 | GNAI2 | S144 | psp | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P08833 | IGFBP1 | S83 | psp | Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}. |
| P09467 | FBP1 | S144 | ochoa|psp | Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
| P09651 | HNRNPA1 | S91 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P09874 | PARP1 | S455 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P10398 | ARAF | S582 | ochoa|psp | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P11233 | RALA | S138 | ochoa | Ras-related protein Ral-A (EC 3.6.5.2) | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors (PubMed:18756269, PubMed:19306925, PubMed:20005108, PubMed:21822277, PubMed:30500825). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (PubMed:21822277). {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:30500825}. |
| P13639 | EEF2 | S23 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P15056 | BRAF | S729 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P20338 | RAB4A | S190 | ochoa | Ras-related protein Rab-4A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P56371, ECO:0000269|PubMed:15907487, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:29425100}. |
| P20339 | RAB5A | S84 | psp | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P21359 | NF1 | S2597 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P23508 | MCC | S681 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P26045 | PTPN3 | S835 | psp | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P26373 | RPL13 | S52 | ochoa | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}. |
| P27448 | MARK3 | S489 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P31930 | UQCRC1 | S212 | ochoa | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179). {ECO:0000250|UniProtKB:P07256, ECO:0000250|UniProtKB:P31800, ECO:0000269|PubMed:33141179, ECO:0000305|PubMed:29243944}. |
| P34897 | SHMT2 | S226 | ochoa | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}. |
| P34931 | HSPA1L | S241 | psp | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35269 | GTF2F1 | S385 | ochoa|psp | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35609 | ACTN2 | S624 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35670 | ATP7B | S1121 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
| P36551 | CPOX | S112 | ochoa | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) | Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX and participates to the sixth step in the heme biosynthetic pathway. {ECO:0000269|PubMed:8159699}. |
| P36897 | TGFBR1 | S360 | ochoa | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P40306 | PSMB10 | S229 | ochoa | Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i) | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. |
| P40429 | RPL13A | S77 | psp | Large ribosomal subunit protein uL13 (23 kDa highly basic protein) (60S ribosomal protein L13a) | Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318). {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P41252 | IARS1 | S346 | ochoa | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| P42330 | AKR1C3 | S32 | ochoa | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}. |
| P42684 | ABL2 | S866 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P48147 | PREP | S667 | ochoa | Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) | Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. |
| P48382 | RFX5 | S308 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P49748 | ACADVL | S590 | ochoa | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P49757 | NUMB | S438 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P50991 | CCT4 | S444 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51149 | RAB7A | S72 | ochoa|psp | Ras-related protein Rab-7a (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38538795). In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445, ECO:0000269|PubMed:38538795}. |
| P51572 | BCAP31 | S216 | ochoa | B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28) | Functions as a chaperone protein (PubMed:18287538, PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:18287538, PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:18287538, PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671). {ECO:0000250|UniProtKB:Q61335, ECO:0000269|PubMed:10958671, ECO:0000269|PubMed:18287538, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:9396746}. |
| P51617 | IRAK1 | S556 | ochoa | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| P51659 | HSD17B4 | S318 | ochoa|psp | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P51991 | HNRNPA3 | S112 | ochoa | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}. |
| P52272 | HNRNPM | S446 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52895 | AKR1C2 | S32 | ochoa | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:15929998, PubMed:17034817, PubMed:17442338, PubMed:8573067). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699, ECO:0000269|PubMed:8573067}. |
| P54646 | PRKAA2 | S483 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| P55072 | VCP | S326 | ochoa|psp | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P55087 | AQP4 | S111 | psp | Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) | Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19383790, ECO:0000269|PubMed:37143309, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}. |
| P60709 | ACTB | S338 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61587 | RND3 | S210 | psp | Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3) | Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. |
| P63261 | ACTG1 | S338 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P78371 | CCT2 | S60 | ochoa | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q01094 | E2F1 | S235 | psp | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}. |
| Q01432 | AMPD3 | S85 | ochoa | AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) | AMP deaminase plays a critical role in energy metabolism. {ECO:0000305|PubMed:9291127}. |
| Q02156 | PRKCE | S380 | ochoa | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q04637 | EIF4G1 | S1187 | ochoa|psp | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q04828 | AKR1C1 | S32 | ochoa | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699}. |
| Q0VF96 | CGNL1 | S431 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q12802 | AKAP13 | S1876 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13164 | MAPK7 | S770 | psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q13263 | TRIM28 | S140 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13554 | CAMK2B | T321 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13613 | MTMR1 | S43 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}. |
| Q13671 | RIN1 | S611 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q13761 | RUNX3 | S149 | psp | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q13936 | CACNA1C | S1718 | ochoa | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:25260352, ECO:0000269|PubMed:25633834, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:30023270, ECO:0000269|PubMed:30172029, ECO:0000269|PubMed:31430211, ECO:0000269|PubMed:34163037, ECO:0000269|PubMed:8099908, ECO:0000305}.; FUNCTION: [Isoform 12]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 13]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 14]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 15]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 16]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 17]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 18]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:8392192}.; FUNCTION: [Isoform 19]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 20]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 21]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 22]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 23]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 24]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 25]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 26]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 27]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 34]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:11741969}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}. |
| Q13950 | RUNX2 | S196 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14161 | GIT2 | S154 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14244 | MAP7 | S242 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14689 | DIP2A | S94 | ochoa | Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) | Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}. |
| Q15382 | RHEB | S130 | psp | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}. |
| Q15699 | ALX1 | S39 | ochoa | ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}. |
| Q16825 | PTPN21 | S658 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q32P51 | HNRNPA1L2 | S91 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q3LXA3 | TKFC | S350 | ochoa | Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)] | Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090). {ECO:0000250|UniProtKB:F1RKQ4, ECO:0000250|UniProtKB:Q4KLZ6, ECO:0000269|PubMed:16289032, ECO:0000269|PubMed:17600090, ECO:0000269|PubMed:32004446, ECO:0000269|PubMed:4688871}. |
| Q495A1 | TIGIT | S183 | ochoa | T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3) | Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells (PubMed:19011627). Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116). Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity (PubMed:32503945). {ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:23154388, ECO:0000269|PubMed:24817116, ECO:0000269|PubMed:32503945}. |
| Q53GL0 | PLEKHO1 | S271 | ochoa | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}. |
| Q5BKX6 | SLC45A4 | S456 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5JSP0 | FGD3 | S446 | ochoa | FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5) | Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q5JSZ5 | PRRC2B | S1754 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SYE7 | NHSL1 | S1089 | ochoa | NHS-like protein 1 | None |
| Q5T0Z8 | C6orf132 | S314 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T0Z8 | C6orf132 | S1087 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T0Z8 | C6orf132 | S1106 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T447 | HECTD3 | S192 | psp | E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) | E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}. |
| Q5T5P2 | KIAA1217 | S433 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TCZ1 | SH3PXD2A | S1016 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5TCZ1 | SH3PXD2A | S1017 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VV41 | ARHGEF16 | S107 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q63HN8 | RNF213 | S217 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q63HR2 | TNS2 | S1247 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q66K14 | TBC1D9B | S411 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q69YN4 | VIRMA | S1651 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6AI14 | SLC9A4 | S660 | ochoa | Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) | Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity). {ECO:0000250|UniProtKB:P26434, ECO:0000250|UniProtKB:Q8BUE1}. |
| Q6DT37 | CDC42BPG | S1482 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6NSJ2 | PHLDB3 | S412 | ochoa | Pleckstrin homology-like domain family B member 3 | None |
| Q6P4F7 | ARHGAP11A | S847 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P589 | TNFAIP8L2 | S78 | ochoa | Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20) | Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed:27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:32188758). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:32460619). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity). {ECO:0000250|UniProtKB:Q9D8Y7, ECO:0000269|PubMed:27043859, ECO:0000269|PubMed:32188758, ECO:0000269|PubMed:32460619}. |
| Q6P996 | PDXDC1 | S737 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PJF5 | RHBDF2 | S113 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6ZN16 | MAP3K15 | S70 | ochoa | Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) | Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases (PubMed:20362554, PubMed:26732173). May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (PubMed:20362554). Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade (PubMed:26732173). {ECO:0000269|PubMed:20362554, ECO:0000269|PubMed:26732173}. |
| Q6ZN55 | ZNF574 | S298 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZNB6 | NFXL1 | S835 | ochoa | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | None |
| Q6ZRV2 | FAM83H | S1003 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZSZ5 | ARHGEF18 | S94 | ochoa | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. |
| Q6ZVM7 | TOM1L2 | S394 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q71H61 | ILDR2 | S547 | ochoa | Immunoglobulin-like domain-containing receptor 2 (Angulin-3) | May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}. |
| Q76I76 | SSH2 | S708 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
| Q7L2K0 | TEDC2 | S159 | ochoa | Tubulin epsilon and delta complex protein 2 | Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability. {ECO:0000250|UniProtKB:Q6GQV0}. |
| Q7Z2K8 | GPRIN1 | S389 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3U7 | MON2 | S207 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q7Z417 | NUFIP2 | S304 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z460 | CLASP1 | S280 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z4H8 | POGLUT3 | S421 | ochoa | Protein O-glucosyltransferase 3 (EC 2.4.1.-) (KDEL motif-containing protein 2) (Protein O-xylosyltransferase POGLUT3) (EC 2.4.2.-) | Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). {ECO:0000269|PubMed:30127001, ECO:0000269|PubMed:34411563}. |
| Q7Z4S6 | KIF21A | S853 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z6Z7 | HUWE1 | S2887 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86SQ0 | PHLDB2 | S242 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UK7 | ZNF598 | S479 | ochoa | E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) | E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32099016, PubMed:32579943, PubMed:33581075). ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28065601, PubMed:28132843, PubMed:28685749). Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:30293783). Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10 (PubMed:28065601, PubMed:28132843, PubMed:28685749). Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:32099016, PubMed:32579943, PubMed:36302773). E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3 (PubMed:28685749). Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs (PubMed:22751931, PubMed:32726578). Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression (PubMed:29719242). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:29719242, ECO:0000269|PubMed:30293783, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33581075, ECO:0000269|PubMed:36302773}.; FUNCTION: (Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10 (PubMed:29719242). Poxvirus encoding mRNAs contain unusual 5' poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts (PubMed:29719242). {ECO:0000269|PubMed:29719242}. |
| Q86UR5 | RIMS1 | S1416 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86UU1 | PHLDB1 | S638 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86UZ6 | ZBTB46 | S326 | ochoa | Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) | Functions as a transcriptional repressor for PRDM1. {ECO:0000250}. |
| Q86V15 | CASZ1 | S1719 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86V48 | LUZP1 | S422 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86V48 | LUZP1 | S903 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86W92 | PPFIBP1 | S540 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q86WR7 | PROSER2 | S400 | ochoa | Proline and serine-rich protein 2 | None |
| Q86X02 | CDR2L | S393 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q8IW93 | ARHGEF19 | S197 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IWC1 | MAP7D3 | S185 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IXI1 | RHOT2 | S156 | psp | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8N165 | PDIK1L | S216 | psp | Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like) | None |
| Q8N2R8 | FAM43A | S383 | ochoa | Protein FAM43A | None |
| Q8N4C6 | NIN | S812 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N5S9 | CAMKK1 | S458 | ochoa|psp | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8N8Z6 | DCBLD1 | S556 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NCN4 | RNF169 | S292 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8ND30 | PPFIBP2 | S512 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8NDI1 | EHBP1 | S854 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFM4 | ADCY4 | S257 | ochoa | Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4) | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. {ECO:0000250|UniProtKB:P26770}. |
| Q8NFY9 | KBTBD8 | S347 | ochoa | Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:26399832}. |
| Q8NHQ8 | RASSF8 | S90 | ochoa | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | None |
| Q8TBE0 | BAHD1 | S121 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TCN5 | ZNF507 | S487 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TCN5 | ZNF507 | S494 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TD26 | CHD6 | S2680 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TER5 | ARHGEF40 | S1082 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TF72 | SHROOM3 | S318 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WXE9 | STON2 | S762 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q8WZ74 | CTTNBP2 | S475 | ochoa | Cortactin-binding protein 2 (CortBP2) | Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons. {ECO:0000250|UniProtKB:Q2IBD4}. |
| Q92615 | LARP4B | S568 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92794 | KAT6A | S1861 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q92879 | CELF1 | S52 | psp | CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}. |
| Q92953 | KCNB2 | S448 | ochoa | Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. {ECO:0000250|UniProtKB:A6H8H5, ECO:0000250|UniProtKB:Q63099}. |
| Q96A65 | EXOC4 | S410 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
| Q96B97 | SH3KBP1 | S230 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96G74 | OTUD5 | S431 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96HB5 | CCDC120 | S360 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96J01 | THOC3 | S273 | ochoa | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q96JG6 | VPS50 | S595 | ochoa | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:25799061}. |
| Q96L73 | NSD1 | S1210 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96P16 | RPRD1A | S285 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
| Q96PE2 | ARHGEF17 | S735 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96QE2 | SLC2A13 | S34 | ochoa | Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) | H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). {ECO:0000269|PubMed:11500374}. |
| Q96S82 | UBL7 | S255 | ochoa | Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132) | Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. {ECO:0000269|PubMed:19690332}. |
| Q99490 | AGAP2 | S927 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99541 | PLIN2 | S222 | ochoa | Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. {ECO:0000269|PubMed:34077757}. |
| Q99988 | GDF15 | S97 | ochoa | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:24971956, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:30639358, ECO:0000269|PubMed:31402172, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:31875646, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:33589633, ECO:0000269|PubMed:36001956, ECO:0000269|PubMed:37060902, ECO:0000269|PubMed:38092039}. |
| Q9BXA9 | SALL3 | S940 | ochoa | Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3) | Probable transcription factor. |
| Q9BZE2 | PUS3 | S45 | ochoa | tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3) | Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. {ECO:0000269|PubMed:27055666}. |
| Q9C029 | TRIM7 | S107 | ochoa | E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27) (Glycogenin-interacting protein) (RING finger protein 90) (Tripartite motif-containing protein 7) | E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration (PubMed:25851810, PubMed:32853985, PubMed:34062120). Acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein or SARS-CoV-2 NSP5 and NSP8 proteins (PubMed:34062120, PubMed:35982226). Mechanistically, recognizes the C-terminal glutamine-containing motif usually generated by viral proteases that process the polyproteins and trigger their ubiquitination and subsequent degradation (PubMed:35867826, PubMed:35893676, PubMed:35982226). Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (By similarity). Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). Mediates the ubiquitination of the SIN3-HDAC chromatin remodeling complex component BRMS1 (PubMed:32853985). Modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells by ubiquitinating NCOA4, leading to its degradation (PubMed:36067704). {ECO:0000250|UniProtKB:Q923T7, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:32126128, ECO:0000269|PubMed:32853985, ECO:0000269|PubMed:34062120, ECO:0000269|PubMed:35867826, ECO:0000269|PubMed:35893676, ECO:0000269|PubMed:35982226, ECO:0000269|PubMed:36067704}.; FUNCTION: (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination. {ECO:0000269|PubMed:32641828}. |
| Q9C0C2 | TNKS1BP1 | S882 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S936 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S1632 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H0A0 | NAT10 | S435 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
| Q9H0H5 | RACGAP1 | S187 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H1B7 | IRF2BPL | S519 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H400 | LIME1 | S95 | ochoa | Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule) | Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}. |
| Q9H788 | SH2D4A | S315 | ochoa | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
| Q9H814 | PHAX | S39 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9HB07 | MYG1 | S39 | ochoa | MYG1 exonuclease (EC 3.1.-.-) | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}. |
| Q9HB21 | PLEKHA1 | S299 | ochoa | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}. |
| Q9HC52 | CBX8 | S256 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
| Q9HCD6 | TANC2 | S1703 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NQT8 | KIF13B | S1778 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NR09 | BIRC6 | S1248 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NR09 | BIRC6 | S3742 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NSK0 | KLC4 | S590 | ochoa|psp | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NV58 | RNF19A | S284 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
| Q9NX63 | CHCHD3 | S179 | ochoa | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q9NYM9 | BET1L | S37 | ochoa | BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15) | Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). {ECO:0000250|UniProtKB:O35152}. |
| Q9NYQ7 | CELSR3 | S3068 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZ71 | RTEL1 | S882 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
| Q9P244 | LRFN1 | S674 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P265 | DIP2B | S100 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P273 | TENM3 | S111 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9P2M4 | TBC1D14 | S91 | ochoa | TBC1 domain family member 14 | Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}. |
| Q9UHB9 | SRP68 | S267 | ochoa | Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38687, ECO:0000269|PubMed:16672232, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| Q9UJ90 | KCNE5 | S95 | ochoa | Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (AMME syndrome candidate gene 2 protein) (Potassium channel subunit beta MiRP4) (Potassium voltage-gated channel subfamily E member 1-like protein) | Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}. |
| Q9UJK0 | TSR3 | S259 | ochoa | 18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (HsTsr3) | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). {ECO:0000305|PubMed:27084949}. |
| Q9UKE5 | TNIK | S1034 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKV8 | AGO2 | S798 | psp | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}. |
| Q9ULD9 | ZNF608 | S440 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULL1 | PLEKHG1 | S695 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULV3 | CIZ1 | S198 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UPP1 | PHF8 | S904 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UQQ2 | SH2B3 | S150 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y259 | CHKB | S40 | psp | Choline/ethanolamine kinase (Choline kinase beta) (CK) (CKB) (EC 2.7.1.32) (Choline kinase-like protein) (Ethanolamine kinase) (EK) (EC 2.7.1.82) (Ethanolamine kinase beta) (EKB) (choline/ethanolamine kinase beta) (CKEKB) | Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:19915674, ECO:0000269|PubMed:21665002}. |
| Q9Y286 | SIGLEC7 | S406 | ochoa | Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}. |
| Q9Y2E4 | DIP2C | S89 | ochoa | Disco-interacting protein 2 homolog C (DIP2 homolog C) | None |
| Q9Y2H0 | DLGAP4 | S665 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2H0 | DLGAP4 | S968 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2K6 | USP20 | S333 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y2U8 | LEMD3 | S407 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2X7 | GIT1 | S154 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y446 | PKP3 | S80 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y490 | TLN1 | S1225 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y6A5 | TACC3 | S558 | ochoa|psp | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q8NBJ7 | SUMF2 | S256 | Sugiyama | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}. |
| P46940 | IQGAP1 | S373 | Sugiyama | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P60174 | TPI1 | S106 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| Q14160 | SCRIB | S917 | Sugiyama | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q16626 | MEA1 | S163 | Sugiyama | Male-enhanced antigen 1 (MEA-1) | May play an important role in spermatogenesis and/or testis development. |
| P18827 | SDC1 | S233 | Sugiyama | Syndecan-1 (SYND1) (CD antigen CD138) | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250|UniProtKB:P18828, ECO:0000269|PubMed:22660413}. |
| P31939 | ATIC | S300 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| O43353 | RIPK2 | S25 | Sugiyama | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) | Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}. |
| P07814 | EPRS1 | S1122 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P61981 | YWHAG | S64 | Sugiyama | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P28329 | CHAT | S594 | SIGNOR|EPSD | Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) | Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. {ECO:0000269|PubMed:17144655}. |
| Q6NYC1 | JMJD6 | Y31 | Sugiyama | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}. |
| Q9UL25 | RAB21 | S143 | Sugiyama | Ras-related protein Rab-21 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18804435, PubMed:25648148, PubMed:31455601). RAB21 is involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601). {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:31455601}. |
| P19429 | TNNI3 | S77 | SIGNOR|iPTMNet|EPSD | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Q6P1J9 | CDC73 | S174 | Sugiyama | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| P49736 | MCM2 | S754 | Sugiyama | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| Q9BQK8 | LPIN3 | S262 | Sugiyama | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}. |
| O14964 | HGS | Y466 | Sugiyama | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
| Q9C0C2 | TNKS1BP1 | S1046 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| Q01082 | SPTBN1 | S446 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| P48751 | SLC4A3 | S67 | GPS6|SIGNOR|ELM|iPTMNet | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}. |
| P58012 | FOXL2 | S263 | ELM|iPTMNet | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| Q13233 | MAP3K1 | S1281 | Sugiyama | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q27J81 | INF2 | S855 | Sugiyama | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| P50542 | PEX5 | S279 | Sugiyama | Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) | Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:11101887, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:17157249, PubMed:17428317, PubMed:21976670, PubMed:26344566, PubMed:7706321, PubMed:7719337, PubMed:7790377). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:17157249, PubMed:21976670, PubMed:26344566). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292). {ECO:0000269|PubMed:11101887, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:12456682, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:17428317, ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337, ECO:0000269|PubMed:7790377}.; FUNCTION: [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129, PubMed:9668159). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232). {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:25538232, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:9668159}.; FUNCTION: [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. {ECO:0000269|PubMed:11546814}. |
| Q8WUA4 | GTF3C2 | S379 | Sugiyama | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q9H078 | CLPB | S155 | Sugiyama | Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842). {ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:32573439, ECO:0000269|PubMed:34115842, ECO:0000269|PubMed:35247700, ECO:0000269|PubMed:36170828, ECO:0000269|PubMed:36745679}. |
| Q9HBH9 | MKNK2 | S394 | Sugiyama | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| Q13126 | MTAP | S123 | Sugiyama | S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) | Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. {ECO:0000255|HAMAP-Rule:MF_03155, ECO:0000269|PubMed:3091600}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.000013 | 4.889 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.000013 | 4.889 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.000013 | 4.889 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.000006 | 5.191 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.000013 | 4.889 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.000013 | 4.892 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.000029 | 4.541 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.000043 | 4.371 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.000056 | 4.249 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.000105 | 3.979 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.000100 | 3.999 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.000212 | 3.675 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.000315 | 3.502 |
| R-HSA-73887 | Death Receptor Signaling | 0.000616 | 3.210 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.001031 | 2.987 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.001121 | 2.950 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.001129 | 2.947 |
| R-HSA-162582 | Signal Transduction | 0.001278 | 2.893 |
| R-HSA-3371511 | HSF1 activation | 0.001623 | 2.790 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.002170 | 2.663 |
| R-HSA-3371568 | Attenuation phase | 0.002380 | 2.623 |
| R-HSA-199991 | Membrane Trafficking | 0.003006 | 2.522 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.003134 | 2.504 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.003220 | 2.492 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.003809 | 2.419 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.003878 | 2.411 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.004097 | 2.388 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.005771 | 2.239 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.006200 | 2.208 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.006225 | 2.206 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.006281 | 2.202 |
| R-HSA-422475 | Axon guidance | 0.007621 | 2.118 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.008333 | 2.079 |
| R-HSA-68911 | G2 Phase | 0.008333 | 2.079 |
| R-HSA-5673000 | RAF activation | 0.008665 | 2.062 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.010911 | 1.962 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.011586 | 1.936 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.011586 | 1.936 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.012232 | 1.912 |
| R-HSA-373753 | Nephrin family interactions | 0.013035 | 1.885 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.014458 | 1.840 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.013902 | 1.857 |
| R-HSA-9675108 | Nervous system development | 0.014361 | 1.843 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.015967 | 1.797 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.015967 | 1.797 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.015702 | 1.804 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.015967 | 1.797 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.016374 | 1.786 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.017560 | 1.755 |
| R-HSA-3371556 | Cellular response to heat stress | 0.016946 | 1.771 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.017578 | 1.755 |
| R-HSA-8854214 | TBC/RABGAPs | 0.017891 | 1.747 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.017891 | 1.747 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.019565 | 1.709 |
| R-HSA-196025 | Formation of annular gap junctions | 0.019565 | 1.709 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.019565 | 1.709 |
| R-HSA-9613354 | Lipophagy | 0.022993 | 1.638 |
| R-HSA-190873 | Gap junction degradation | 0.022993 | 1.638 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.019239 | 1.716 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.022993 | 1.638 |
| R-HSA-9620244 | Long-term potentiation | 0.022855 | 1.641 |
| R-HSA-176974 | Unwinding of DNA | 0.022993 | 1.638 |
| R-HSA-3214842 | HDMs demethylate histones | 0.022855 | 1.641 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.019565 | 1.709 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.020260 | 1.693 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.019565 | 1.709 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.019565 | 1.709 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.023621 | 1.627 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.023621 | 1.627 |
| R-HSA-1483255 | PI Metabolism | 0.023621 | 1.627 |
| R-HSA-70263 | Gluconeogenesis | 0.024161 | 1.617 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.026649 | 1.574 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.026814 | 1.572 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.024791 | 1.606 |
| R-HSA-112316 | Neuronal System | 0.029849 | 1.525 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.030025 | 1.523 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.030213 | 1.520 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.030522 | 1.515 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.035756 | 1.447 |
| R-HSA-182971 | EGFR downregulation | 0.035756 | 1.447 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.035668 | 1.448 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.033011 | 1.481 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.036510 | 1.438 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.038518 | 1.414 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.040732 | 1.390 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.074353 | 1.129 |
| R-HSA-198765 | Signalling to ERK5 | 0.074353 | 1.129 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.074353 | 1.129 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.074353 | 1.129 |
| R-HSA-8941237 | Invadopodia formation | 0.092064 | 1.036 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.109436 | 0.961 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.109436 | 0.961 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.126478 | 0.898 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.126478 | 0.898 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.143194 | 0.844 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.043351 | 1.363 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.159591 | 0.797 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.159591 | 0.797 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.052821 | 1.277 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.052821 | 1.277 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.175676 | 0.755 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.062948 | 1.201 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.191454 | 0.718 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.206931 | 0.684 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.237004 | 0.625 |
| R-HSA-429947 | Deadenylation of mRNA | 0.115037 | 0.939 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.115037 | 0.939 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.251611 | 0.599 |
| R-HSA-202670 | ERKs are inactivated | 0.251611 | 0.599 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.265940 | 0.575 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.265940 | 0.575 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.265940 | 0.575 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.265940 | 0.575 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.265940 | 0.575 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.265940 | 0.575 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.140760 | 0.852 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.279995 | 0.553 |
| R-HSA-1663150 | The activation of arylsulfatases | 0.293782 | 0.532 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.307306 | 0.512 |
| R-HSA-390522 | Striated Muscle Contraction | 0.181267 | 0.742 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.181267 | 0.742 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.320572 | 0.494 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.333584 | 0.477 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.333584 | 0.477 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.346348 | 0.460 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.346348 | 0.460 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.150125 | 0.824 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.371150 | 0.430 |
| R-HSA-156902 | Peptide chain elongation | 0.120207 | 0.920 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.133498 | 0.875 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.147359 | 0.832 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.199770 | 0.699 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.203713 | 0.691 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.203713 | 0.691 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.322537 | 0.491 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.329567 | 0.482 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.219707 | 0.658 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.219707 | 0.658 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.304682 | 0.516 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.202116 | 0.694 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.154045 | 0.812 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.140760 | 0.852 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.067108 | 1.173 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.154045 | 0.812 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.182833 | 0.738 |
| R-HSA-9664873 | Pexophagy | 0.222112 | 0.653 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.283777 | 0.547 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.278569 | 0.555 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.322537 | 0.491 |
| R-HSA-6798695 | Neutrophil degranulation | 0.320388 | 0.494 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.150909 | 0.821 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.175676 | 0.755 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.206931 | 0.684 |
| R-HSA-9033241 | Peroxisomal protein import | 0.141165 | 0.850 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.188182 | 0.725 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.265940 | 0.575 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.126478 | 0.898 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.159591 | 0.797 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.073668 | 1.133 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.127744 | 0.894 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.293782 | 0.532 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.244289 | 0.612 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.341378 | 0.467 |
| R-HSA-3928664 | Ephrin signaling | 0.358868 | 0.445 |
| R-HSA-991365 | Activation of GABAB receptors | 0.251590 | 0.599 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.244289 | 0.612 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.143194 | 0.844 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.175676 | 0.755 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.181267 | 0.742 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.333584 | 0.477 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.336137 | 0.473 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.159591 | 0.797 |
| R-HSA-391251 | Protein folding | 0.315162 | 0.501 |
| R-HSA-72766 | Translation | 0.255921 | 0.592 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.188182 | 0.725 |
| R-HSA-977444 | GABA B receptor activation | 0.251590 | 0.599 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.136911 | 0.864 |
| R-HSA-9694614 | Attachment and Entry | 0.096655 | 1.015 |
| R-HSA-165159 | MTOR signalling | 0.073808 | 1.132 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.074353 | 1.129 |
| R-HSA-8866376 | Reelin signalling pathway | 0.126478 | 0.898 |
| R-HSA-9636569 | Suppression of autophagy | 0.126478 | 0.898 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.143194 | 0.844 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.043351 | 1.363 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.048000 | 1.319 |
| R-HSA-8875656 | MET receptor recycling | 0.191454 | 0.718 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.090732 | 1.042 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.222112 | 0.653 |
| R-HSA-192814 | vRNA Synthesis | 0.237004 | 0.625 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.251611 | 0.599 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.251611 | 0.599 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.279995 | 0.553 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.333584 | 0.477 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.069923 | 1.155 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.358868 | 0.445 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.358868 | 0.445 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.358868 | 0.445 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.371150 | 0.430 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.336137 | 0.473 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.358868 | 0.445 |
| R-HSA-170968 | Frs2-mediated activation | 0.279995 | 0.553 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.251590 | 0.599 |
| R-HSA-169893 | Prolonged ERK activation events | 0.320572 | 0.494 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.084922 | 1.071 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.212842 | 0.672 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.304682 | 0.516 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.109436 | 0.961 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.175676 | 0.755 |
| R-HSA-171007 | p38MAPK events | 0.307306 | 0.512 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.307306 | 0.512 |
| R-HSA-9609507 | Protein localization | 0.237192 | 0.625 |
| R-HSA-112040 | G-protein mediated events | 0.058913 | 1.230 |
| R-HSA-418597 | G alpha (z) signalling events | 0.123824 | 0.907 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.357466 | 0.447 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.057807 | 1.238 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.102684 | 0.988 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.279995 | 0.553 |
| R-HSA-9612973 | Autophagy | 0.247858 | 0.606 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.154672 | 0.811 |
| R-HSA-187687 | Signalling to ERKs | 0.195133 | 0.710 |
| R-HSA-9635644 | Inhibition of membrane repair | 0.056298 | 1.250 |
| R-HSA-429593 | Inositol transporters | 0.126478 | 0.898 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.143194 | 0.844 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.143194 | 0.844 |
| R-HSA-170984 | ARMS-mediated activation | 0.206931 | 0.684 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.090732 | 1.042 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.222112 | 0.653 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.237004 | 0.625 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.251611 | 0.599 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.154045 | 0.812 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.358868 | 0.445 |
| R-HSA-9663891 | Selective autophagy | 0.120207 | 0.920 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.154045 | 0.812 |
| R-HSA-1632852 | Macroautophagy | 0.192658 | 0.715 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.083511 | 1.078 |
| R-HSA-111933 | Calmodulin induced events | 0.051668 | 1.287 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.217149 | 0.663 |
| R-HSA-397014 | Muscle contraction | 0.293121 | 0.533 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.088053 | 1.055 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.207679 | 0.683 |
| R-HSA-111997 | CaM pathway | 0.051668 | 1.287 |
| R-HSA-983189 | Kinesins | 0.044071 | 1.356 |
| R-HSA-437239 | Recycling pathway of L1 | 0.091782 | 1.037 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.160776 | 0.794 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.174391 | 0.758 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.244289 | 0.612 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.367522 | 0.435 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.131240 | 0.882 |
| R-HSA-5689603 | UCH proteinases | 0.222164 | 0.653 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.161751 | 0.791 |
| R-HSA-111885 | Opioid Signalling | 0.184240 | 0.735 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.161751 | 0.791 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.161751 | 0.791 |
| R-HSA-3214847 | HATs acetylate histones | 0.357080 | 0.447 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.048813 | 1.311 |
| R-HSA-111996 | Ca-dependent events | 0.073808 | 1.132 |
| R-HSA-1538133 | G0 and Early G1 | 0.167560 | 0.776 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.223758 | 0.650 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.236024 | 0.627 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.052821 | 1.277 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.057807 | 1.238 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.175676 | 0.755 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.191454 | 0.718 |
| R-HSA-425381 | Bicarbonate transporters | 0.237004 | 0.625 |
| R-HSA-428540 | Activation of RAC1 | 0.251611 | 0.599 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.265940 | 0.575 |
| R-HSA-432047 | Passive transport by Aquaporins | 0.333584 | 0.477 |
| R-HSA-163615 | PKA activation | 0.358868 | 0.445 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.371150 | 0.430 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.371150 | 0.430 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.322537 | 0.491 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.256805 | 0.590 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.233666 | 0.631 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.256805 | 0.590 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.269447 | 0.570 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.223219 | 0.651 |
| R-HSA-5576891 | Cardiac conduction | 0.316592 | 0.499 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.273370 | 0.563 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.346616 | 0.460 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.269447 | 0.570 |
| R-HSA-68875 | Mitotic Prophase | 0.120049 | 0.921 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.203713 | 0.691 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.043364 | 1.363 |
| R-HSA-8876725 | Protein methylation | 0.052821 | 1.277 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.237004 | 0.625 |
| R-HSA-1483213 | Synthesis of PE | 0.134216 | 0.872 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.174391 | 0.758 |
| R-HSA-112043 | PLC beta mediated events | 0.150125 | 0.824 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.247750 | 0.606 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.280049 | 0.553 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.054602 | 1.263 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.322537 | 0.491 |
| R-HSA-1640170 | Cell Cycle | 0.336343 | 0.473 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.236024 | 0.627 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.175676 | 0.755 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.084922 | 1.071 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.096655 | 1.015 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.237004 | 0.625 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 0.237004 | 0.625 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.279995 | 0.553 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.293782 | 0.532 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.167560 | 0.776 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.307306 | 0.512 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.307306 | 0.512 |
| R-HSA-70350 | Fructose catabolism | 0.320572 | 0.494 |
| R-HSA-190828 | Gap junction trafficking | 0.265820 | 0.575 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.272936 | 0.564 |
| R-HSA-9634597 | GPER1 signaling | 0.294257 | 0.531 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.370733 | 0.431 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.082811 | 1.082 |
| R-HSA-2559583 | Cellular Senescence | 0.093708 | 1.028 |
| R-HSA-9945266 | Differentiation of T cells | 0.320572 | 0.494 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.320572 | 0.494 |
| R-HSA-8852135 | Protein ubiquitination | 0.078727 | 1.104 |
| R-HSA-450294 | MAP kinase activation | 0.150125 | 0.824 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.357466 | 0.447 |
| R-HSA-422356 | Regulation of insulin secretion | 0.351851 | 0.454 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.082811 | 1.082 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.160776 | 0.794 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.307306 | 0.512 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.346348 | 0.460 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.154492 | 0.811 |
| R-HSA-114608 | Platelet degranulation | 0.295037 | 0.530 |
| R-HSA-4839726 | Chromatin organization | 0.265852 | 0.575 |
| R-HSA-177929 | Signaling by EGFR | 0.128083 | 0.893 |
| R-HSA-1483191 | Synthesis of PC | 0.091782 | 1.037 |
| R-HSA-70326 | Glucose metabolism | 0.248446 | 0.605 |
| R-HSA-448424 | Interleukin-17 signaling | 0.192466 | 0.716 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.057807 | 1.238 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.084922 | 1.071 |
| R-HSA-5689877 | Josephin domain DUBs | 0.222112 | 0.653 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.293782 | 0.532 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.272936 | 0.564 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.301347 | 0.521 |
| R-HSA-163685 | Integration of energy metabolism | 0.176390 | 0.754 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.370733 | 0.431 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.315162 | 0.501 |
| R-HSA-5688426 | Deubiquitination | 0.088509 | 1.053 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.096655 | 1.015 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.058913 | 1.230 |
| R-HSA-9659379 | Sensory processing of sound | 0.237343 | 0.625 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.364377 | 0.438 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.222885 | 0.652 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.143194 | 0.844 |
| R-HSA-9635465 | Suppression of apoptosis | 0.237004 | 0.625 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.140760 | 0.852 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.307306 | 0.512 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.346348 | 0.460 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.110638 | 0.956 |
| R-HSA-1237112 | Methionine salvage pathway | 0.371150 | 0.430 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.182802 | 0.738 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.197346 | 0.705 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.325254 | 0.488 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.278569 | 0.555 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.351312 | 0.454 |
| R-HSA-69190 | DNA strand elongation | 0.167560 | 0.776 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.092590 | 1.033 |
| R-HSA-70171 | Glycolysis | 0.362304 | 0.441 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.175676 | 0.755 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.320572 | 0.494 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.128083 | 0.893 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.247559 | 0.606 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.165427 | 0.781 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.057807 | 1.238 |
| R-HSA-449836 | Other interleukin signaling | 0.371150 | 0.430 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.287157 | 0.542 |
| R-HSA-5578775 | Ion homeostasis | 0.350527 | 0.455 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.048000 | 1.319 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.371150 | 0.430 |
| R-HSA-373760 | L1CAM interactions | 0.109444 | 0.961 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.287157 | 0.542 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.320921 | 0.494 |
| R-HSA-2262752 | Cellular responses to stress | 0.107711 | 0.968 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.197346 | 0.705 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.258704 | 0.587 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.211667 | 0.674 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.052821 | 1.277 |
| R-HSA-9678110 | Attachment and Entry | 0.320572 | 0.494 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.216163 | 0.665 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.350527 | 0.455 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.189622 | 0.722 |
| R-HSA-381042 | PERK regulates gene expression | 0.195133 | 0.710 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.276864 | 0.558 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.070422 | 1.152 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.358868 | 0.445 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.068448 | 1.165 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.364377 | 0.438 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.085082 | 1.070 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.127744 | 0.894 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.330894 | 0.480 |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 0.048813 | 1.311 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.132394 | 0.878 |
| R-HSA-9607240 | FLT3 Signaling | 0.237382 | 0.625 |
| R-HSA-1483257 | Phospholipid metabolism | 0.159501 | 0.797 |
| R-HSA-168255 | Influenza Infection | 0.336610 | 0.473 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.244482 | 0.612 |
| R-HSA-69236 | G1 Phase | 0.265820 | 0.575 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.265820 | 0.575 |
| R-HSA-6806834 | Signaling by MET | 0.242442 | 0.615 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.169544 | 0.771 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.333584 | 0.477 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.265220 | 0.576 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.113788 | 0.944 |
| R-HSA-190236 | Signaling by FGFR | 0.161751 | 0.791 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.265820 | 0.575 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.273686 | 0.563 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.133498 | 0.875 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.357080 | 0.447 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.084235 | 1.075 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.371261 | 0.430 |
| R-HSA-192823 | Viral mRNA Translation | 0.377934 | 0.423 |
| R-HSA-977443 | GABA receptor activation | 0.378114 | 0.422 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.378114 | 0.422 |
| R-HSA-379724 | tRNA Aminoacylation | 0.378114 | 0.422 |
| R-HSA-5617833 | Cilium Assembly | 0.378328 | 0.422 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.383127 | 0.417 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.383127 | 0.417 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.383196 | 0.417 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.383196 | 0.417 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.383196 | 0.417 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.383196 | 0.417 |
| R-HSA-9629569 | Protein hydroxylation | 0.383196 | 0.417 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.384936 | 0.415 |
| R-HSA-1268020 | Mitochondrial protein import | 0.391726 | 0.407 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.393483 | 0.405 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.393511 | 0.405 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.394725 | 0.404 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.395013 | 0.403 |
| R-HSA-198753 | ERK/MAPK targets | 0.395013 | 0.403 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.395013 | 0.403 |
| R-HSA-167044 | Signalling to RAS | 0.395013 | 0.403 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.395013 | 0.403 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.398482 | 0.400 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.398482 | 0.400 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.398482 | 0.400 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.398645 | 0.399 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.399049 | 0.399 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.399979 | 0.398 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.405203 | 0.392 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.405203 | 0.392 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.406604 | 0.391 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.406604 | 0.391 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.407681 | 0.390 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.416224 | 0.381 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.417974 | 0.379 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.417974 | 0.379 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.417974 | 0.379 |
| R-HSA-5652084 | Fructose metabolism | 0.417974 | 0.379 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.417974 | 0.379 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.417974 | 0.379 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.418535 | 0.378 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.418535 | 0.378 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.419165 | 0.378 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.419165 | 0.378 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.429126 | 0.367 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.429126 | 0.367 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.429126 | 0.367 |
| R-HSA-3000170 | Syndecan interactions | 0.429126 | 0.367 |
| R-HSA-200425 | Carnitine shuttle | 0.429126 | 0.367 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.434403 | 0.362 |
| R-HSA-72172 | mRNA Splicing | 0.435051 | 0.361 |
| R-HSA-9865881 | Complex III assembly | 0.440066 | 0.356 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.440066 | 0.356 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.440066 | 0.356 |
| R-HSA-9711097 | Cellular response to starvation | 0.441929 | 0.355 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.449070 | 0.348 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.450405 | 0.346 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.450796 | 0.346 |
| R-HSA-9839394 | TGFBR3 expression | 0.450796 | 0.346 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.450796 | 0.346 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.450796 | 0.346 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.450796 | 0.346 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.450796 | 0.346 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.450796 | 0.346 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.451181 | 0.346 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.457586 | 0.340 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.461322 | 0.336 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.461322 | 0.336 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.461322 | 0.336 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.461322 | 0.336 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.461322 | 0.336 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.461322 | 0.336 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.463948 | 0.334 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.463948 | 0.334 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.464108 | 0.333 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.470265 | 0.328 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.471646 | 0.326 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.471646 | 0.326 |
| R-HSA-8949613 | Cristae formation | 0.471646 | 0.326 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.471646 | 0.326 |
| R-HSA-264876 | Insulin processing | 0.471646 | 0.326 |
| R-HSA-1500931 | Cell-Cell communication | 0.472590 | 0.326 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.474269 | 0.324 |
| R-HSA-380287 | Centrosome maturation | 0.476538 | 0.322 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.476538 | 0.322 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.481773 | 0.317 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.481773 | 0.317 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.481773 | 0.317 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.481773 | 0.317 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.481773 | 0.317 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.481773 | 0.317 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.481773 | 0.317 |
| R-HSA-9757110 | Prednisone ADME | 0.481773 | 0.317 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.484864 | 0.314 |
| R-HSA-8953854 | Metabolism of RNA | 0.488101 | 0.311 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.491707 | 0.308 |
| R-HSA-72086 | mRNA Capping | 0.491707 | 0.308 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.491707 | 0.308 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.491707 | 0.308 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.491707 | 0.308 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.491707 | 0.308 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.493718 | 0.307 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.501451 | 0.300 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.501451 | 0.300 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.501451 | 0.300 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.502382 | 0.299 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.504370 | 0.297 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.507213 | 0.295 |
| R-HSA-69206 | G1/S Transition | 0.508069 | 0.294 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.508427 | 0.294 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.508427 | 0.294 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.508427 | 0.294 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.511008 | 0.292 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.511008 | 0.292 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.516498 | 0.287 |
| R-HSA-69481 | G2/M Checkpoints | 0.517518 | 0.286 |
| R-HSA-68886 | M Phase | 0.517812 | 0.286 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.518685 | 0.285 |
| R-HSA-2024096 | HS-GAG degradation | 0.520383 | 0.284 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.520383 | 0.284 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.520383 | 0.284 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.520608 | 0.283 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.522206 | 0.282 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.528368 | 0.277 |
| R-HSA-354192 | Integrin signaling | 0.529579 | 0.276 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.529579 | 0.276 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.529579 | 0.276 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.529579 | 0.276 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.529579 | 0.276 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.529579 | 0.276 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.529579 | 0.276 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.530897 | 0.275 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.530897 | 0.275 |
| R-HSA-72312 | rRNA processing | 0.537084 | 0.270 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.538599 | 0.269 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.538599 | 0.269 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.538599 | 0.269 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.538599 | 0.269 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.538599 | 0.269 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.542446 | 0.266 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.542446 | 0.266 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.547447 | 0.262 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.547447 | 0.262 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.547447 | 0.262 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.547447 | 0.262 |
| R-HSA-392518 | Signal amplification | 0.547447 | 0.262 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.547447 | 0.262 |
| R-HSA-5365859 | RA biosynthesis pathway | 0.547447 | 0.262 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.548146 | 0.261 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.556125 | 0.255 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.559397 | 0.252 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.564638 | 0.248 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.564638 | 0.248 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.564638 | 0.248 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.564638 | 0.248 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.564638 | 0.248 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.564638 | 0.248 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.564638 | 0.248 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.564638 | 0.248 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.564638 | 0.248 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.564638 | 0.248 |
| R-HSA-8853659 | RET signaling | 0.564638 | 0.248 |
| R-HSA-157118 | Signaling by NOTCH | 0.564712 | 0.248 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.570447 | 0.244 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.570447 | 0.244 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.572069 | 0.243 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.572988 | 0.242 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 0.572988 | 0.242 |
| R-HSA-419037 | NCAM1 interactions | 0.572988 | 0.242 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.572988 | 0.242 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.578683 | 0.238 |
| R-HSA-6807070 | PTEN Regulation | 0.580784 | 0.236 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 0.581178 | 0.236 |
| R-HSA-74217 | Purine salvage | 0.581178 | 0.236 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.581178 | 0.236 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.589212 | 0.230 |
| R-HSA-69541 | Stabilization of p53 | 0.589212 | 0.230 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.589212 | 0.230 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.589212 | 0.230 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.589212 | 0.230 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.591942 | 0.228 |
| R-HSA-109582 | Hemostasis | 0.593118 | 0.227 |
| R-HSA-449147 | Signaling by Interleukins | 0.594968 | 0.226 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.597092 | 0.224 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.597092 | 0.224 |
| R-HSA-167169 | HIV Transcription Elongation | 0.597092 | 0.224 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.597092 | 0.224 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.597092 | 0.224 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.597092 | 0.224 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.597092 | 0.224 |
| R-HSA-9646399 | Aggrephagy | 0.597092 | 0.224 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.597165 | 0.224 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.597874 | 0.223 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.604821 | 0.218 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.604821 | 0.218 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.604821 | 0.218 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.604821 | 0.218 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.604821 | 0.218 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.604821 | 0.218 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.611598 | 0.214 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.612403 | 0.213 |
| R-HSA-167161 | HIV Transcription Initiation | 0.612403 | 0.213 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.612403 | 0.213 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.612403 | 0.213 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.612403 | 0.213 |
| R-HSA-189451 | Heme biosynthesis | 0.612403 | 0.213 |
| R-HSA-2187338 | Visual phototransduction | 0.618590 | 0.209 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.618695 | 0.209 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.619839 | 0.208 |
| R-HSA-166520 | Signaling by NTRKs | 0.622646 | 0.206 |
| R-HSA-69242 | S Phase | 0.622646 | 0.206 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.627133 | 0.203 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.627133 | 0.203 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.627133 | 0.203 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.627133 | 0.203 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.632504 | 0.199 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.632504 | 0.199 |
| R-HSA-5357801 | Programmed Cell Death | 0.632643 | 0.199 |
| R-HSA-597592 | Post-translational protein modification | 0.632842 | 0.199 |
| R-HSA-9907900 | Proteasome assembly | 0.634288 | 0.198 |
| R-HSA-373752 | Netrin-1 signaling | 0.634288 | 0.198 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.634636 | 0.197 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.637347 | 0.196 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.641306 | 0.193 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.641306 | 0.193 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.641306 | 0.193 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.641306 | 0.193 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.641306 | 0.193 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.641306 | 0.193 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.641306 | 0.193 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.641306 | 0.193 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.642141 | 0.192 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.642481 | 0.192 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.646359 | 0.190 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.646359 | 0.190 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.648190 | 0.188 |
| R-HSA-75153 | Apoptotic execution phase | 0.648190 | 0.188 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.651577 | 0.186 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 0.654942 | 0.184 |
| R-HSA-9833110 | RSV-host interactions | 0.656221 | 0.183 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.660816 | 0.180 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.661565 | 0.179 |
| R-HSA-425410 | Metal ion SLC transporters | 0.661565 | 0.179 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.668061 | 0.175 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.668061 | 0.175 |
| R-HSA-73893 | DNA Damage Bypass | 0.668061 | 0.175 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.668061 | 0.175 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.669002 | 0.175 |
| R-HSA-69239 | Synthesis of DNA | 0.669857 | 0.174 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.674433 | 0.171 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.674433 | 0.171 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.674433 | 0.171 |
| R-HSA-388396 | GPCR downstream signalling | 0.675238 | 0.171 |
| R-HSA-1280218 | Adaptive Immune System | 0.675250 | 0.171 |
| R-HSA-418990 | Adherens junctions interactions | 0.675669 | 0.170 |
| R-HSA-109581 | Apoptosis | 0.676310 | 0.170 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.678703 | 0.168 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.678703 | 0.168 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.680683 | 0.167 |
| R-HSA-72187 | mRNA 3'-end processing | 0.686813 | 0.163 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.686813 | 0.163 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.686813 | 0.163 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.686813 | 0.163 |
| R-HSA-9658195 | Leishmania infection | 0.691604 | 0.160 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.691604 | 0.160 |
| R-HSA-168256 | Immune System | 0.692612 | 0.160 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.692826 | 0.159 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.692826 | 0.159 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.692826 | 0.159 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.692826 | 0.159 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.692826 | 0.159 |
| R-HSA-72649 | Translation initiation complex formation | 0.698724 | 0.156 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.699974 | 0.155 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.700357 | 0.155 |
| R-HSA-392499 | Metabolism of proteins | 0.702054 | 0.154 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.704509 | 0.152 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.706314 | 0.151 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.707726 | 0.150 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.710183 | 0.149 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.710183 | 0.149 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.710183 | 0.149 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.712169 | 0.147 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.717666 | 0.144 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.717666 | 0.144 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.718197 | 0.144 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.720067 | 0.143 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.720921 | 0.142 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.721208 | 0.142 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.721208 | 0.142 |
| R-HSA-5693538 | Homology Directed Repair | 0.723948 | 0.140 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.726562 | 0.139 |
| R-HSA-180786 | Extension of Telomeres | 0.726562 | 0.139 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.726562 | 0.139 |
| R-HSA-191859 | snRNP Assembly | 0.726562 | 0.139 |
| R-HSA-8979227 | Triglyceride metabolism | 0.726562 | 0.139 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.726562 | 0.139 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.731815 | 0.136 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.731815 | 0.136 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.731815 | 0.136 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.735317 | 0.134 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.735317 | 0.134 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.736966 | 0.133 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.736966 | 0.133 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.736966 | 0.133 |
| R-HSA-8956321 | Nucleotide salvage | 0.736966 | 0.133 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.742019 | 0.130 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.742019 | 0.130 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.746975 | 0.127 |
| R-HSA-373755 | Semaphorin interactions | 0.746975 | 0.127 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.751836 | 0.124 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.753382 | 0.123 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.753382 | 0.123 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.753382 | 0.123 |
| R-HSA-194138 | Signaling by VEGF | 0.753382 | 0.123 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.756604 | 0.121 |
| R-HSA-69275 | G2/M Transition | 0.757732 | 0.120 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.765868 | 0.116 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.765868 | 0.116 |
| R-HSA-421270 | Cell-cell junction organization | 0.768695 | 0.114 |
| R-HSA-167172 | Transcription of the HIV genome | 0.770368 | 0.113 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.770368 | 0.113 |
| R-HSA-5218859 | Regulated Necrosis | 0.770368 | 0.113 |
| R-HSA-68877 | Mitotic Prometaphase | 0.777340 | 0.109 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.779109 | 0.108 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.779109 | 0.108 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.779109 | 0.108 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.779109 | 0.108 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.780794 | 0.107 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.783355 | 0.106 |
| R-HSA-189445 | Metabolism of porphyrins | 0.783355 | 0.106 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.787519 | 0.104 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.787519 | 0.104 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.787519 | 0.104 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.787519 | 0.104 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.791464 | 0.102 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.791604 | 0.101 |
| R-HSA-4086398 | Ca2+ pathway | 0.791604 | 0.101 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.792914 | 0.101 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.795450 | 0.099 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.795450 | 0.099 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.795610 | 0.099 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.795610 | 0.099 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.795610 | 0.099 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.803076 | 0.095 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.803394 | 0.095 |
| R-HSA-372790 | Signaling by GPCR | 0.803642 | 0.095 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.806544 | 0.093 |
| R-HSA-9664407 | Parasite infection | 0.807058 | 0.093 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.807058 | 0.093 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.807058 | 0.093 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.807174 | 0.093 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.809867 | 0.092 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.810882 | 0.091 |
| R-HSA-5619084 | ABC transporter disorders | 0.810882 | 0.091 |
| R-HSA-4086400 | PCP/CE pathway | 0.810882 | 0.091 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.814519 | 0.089 |
| R-HSA-9833482 | PKR-mediated signaling | 0.818086 | 0.087 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.818086 | 0.087 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.825016 | 0.084 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.825016 | 0.084 |
| R-HSA-446728 | Cell junction organization | 0.828172 | 0.082 |
| R-HSA-1266738 | Developmental Biology | 0.829501 | 0.081 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.831683 | 0.080 |
| R-HSA-68882 | Mitotic Anaphase | 0.834882 | 0.078 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.834921 | 0.078 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.836976 | 0.077 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.840839 | 0.075 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.841212 | 0.075 |
| R-HSA-69306 | DNA Replication | 0.843202 | 0.074 |
| R-HSA-74160 | Gene expression (Transcription) | 0.847097 | 0.072 |
| R-HSA-1989781 | PPARA activates gene expression | 0.847834 | 0.072 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.849929 | 0.071 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.850203 | 0.070 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.852342 | 0.069 |
| R-HSA-73884 | Base Excision Repair | 0.853086 | 0.069 |
| R-HSA-202424 | Downstream TCR signaling | 0.853086 | 0.069 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.858701 | 0.066 |
| R-HSA-73894 | DNA Repair | 0.858867 | 0.066 |
| R-HSA-195721 | Signaling by WNT | 0.863582 | 0.064 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.864074 | 0.063 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.866691 | 0.062 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.867178 | 0.062 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.869257 | 0.061 |
| R-HSA-9679506 | SARS-CoV Infections | 0.869263 | 0.061 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.874243 | 0.058 |
| R-HSA-1296071 | Potassium Channels | 0.874243 | 0.058 |
| R-HSA-8939211 | ESR-mediated signaling | 0.874282 | 0.058 |
| R-HSA-168249 | Innate Immune System | 0.875145 | 0.058 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.876665 | 0.057 |
| R-HSA-157579 | Telomere Maintenance | 0.876665 | 0.057 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.879040 | 0.056 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.879040 | 0.056 |
| R-HSA-72306 | tRNA processing | 0.880638 | 0.055 |
| R-HSA-418555 | G alpha (s) signalling events | 0.882455 | 0.054 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.883654 | 0.054 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.885895 | 0.053 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.890248 | 0.050 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.899013 | 0.046 |
| R-HSA-8957322 | Metabolism of steroids | 0.900152 | 0.046 |
| R-HSA-211000 | Gene Silencing by RNA | 0.900421 | 0.046 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.902340 | 0.045 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.902340 | 0.045 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.902352 | 0.045 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.904222 | 0.044 |
| R-HSA-202403 | TCR signaling | 0.906067 | 0.043 |
| R-HSA-6803157 | Antimicrobial peptides | 0.907878 | 0.042 |
| R-HSA-1474244 | Extracellular matrix organization | 0.908397 | 0.042 |
| R-HSA-212436 | Generic Transcription Pathway | 0.909237 | 0.041 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.909653 | 0.041 |
| R-HSA-983712 | Ion channel transport | 0.911081 | 0.040 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.913103 | 0.039 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.914778 | 0.039 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.915167 | 0.038 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.917289 | 0.037 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.918032 | 0.037 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.921163 | 0.036 |
| R-HSA-73886 | Chromosome Maintenance | 0.927071 | 0.033 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.929857 | 0.032 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.929857 | 0.032 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.930765 | 0.031 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.931210 | 0.031 |
| R-HSA-9824446 | Viral Infection Pathways | 0.935106 | 0.029 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.935116 | 0.029 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.938885 | 0.027 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.939669 | 0.027 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.939981 | 0.027 |
| R-HSA-5663205 | Infectious disease | 0.947117 | 0.024 |
| R-HSA-8951664 | Neddylation | 0.947386 | 0.023 |
| R-HSA-5368287 | Mitochondrial translation | 0.950612 | 0.022 |
| R-HSA-913531 | Interferon Signaling | 0.953552 | 0.021 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.955201 | 0.020 |
| R-HSA-15869 | Metabolism of nucleotides | 0.958751 | 0.018 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.961455 | 0.017 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.961675 | 0.017 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.963142 | 0.016 |
| R-HSA-2142753 | Arachidonate metabolism | 0.963142 | 0.016 |
| R-HSA-418594 | G alpha (i) signalling events | 0.966319 | 0.015 |
| R-HSA-8978868 | Fatty acid metabolism | 0.966319 | 0.015 |
| R-HSA-162587 | HIV Life Cycle | 0.966570 | 0.015 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.967217 | 0.014 |
| R-HSA-877300 | Interferon gamma signaling | 0.967850 | 0.014 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.973556 | 0.012 |
| R-HSA-416476 | G alpha (q) signalling events | 0.973991 | 0.011 |
| R-HSA-611105 | Respiratory electron transport | 0.978250 | 0.010 |
| R-HSA-3781865 | Diseases of glycosylation | 0.980658 | 0.008 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.983781 | 0.007 |
| R-HSA-9609690 | HCMV Early Events | 0.984706 | 0.007 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.985091 | 0.007 |
| R-HSA-428157 | Sphingolipid metabolism | 0.986132 | 0.006 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.986665 | 0.006 |
| R-HSA-6805567 | Keratinization | 0.987670 | 0.005 |
| R-HSA-9748784 | Drug ADME | 0.990253 | 0.004 |
| R-HSA-162906 | HIV Infection | 0.991830 | 0.004 |
| R-HSA-1643685 | Disease | 0.991834 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.991845 | 0.004 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.992145 | 0.003 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.992297 | 0.003 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.993286 | 0.003 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.994483 | 0.002 |
| R-HSA-9609646 | HCMV Infection | 0.994798 | 0.002 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.997000 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.997515 | 0.001 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.999134 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999845 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999977 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999998 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK2 |
0.860 | 0.718 | -3 | 0.728 |
SRPK2 |
0.855 | 0.708 | -3 | 0.829 |
P90RSK |
0.855 | 0.742 | -3 | 0.729 |
SRPK1 |
0.854 | 0.671 | -3 | 0.763 |
PRKD2 |
0.854 | 0.664 | -3 | 0.664 |
MAPKAPK2 |
0.854 | 0.686 | -3 | 0.718 |
RSK3 |
0.854 | 0.707 | -3 | 0.728 |
CDKL5 |
0.852 | 0.708 | -3 | 0.702 |
AKT2 |
0.850 | 0.739 | -3 | 0.799 |
RSK4 |
0.848 | 0.668 | -3 | 0.750 |
PRKX |
0.848 | 0.593 | -3 | 0.739 |
CDKL1 |
0.847 | 0.788 | -3 | 0.683 |
PIM1 |
0.847 | 0.695 | -3 | 0.689 |
PRKD3 |
0.846 | 0.714 | -3 | 0.713 |
MAPKAPK3 |
0.846 | 0.675 | -3 | 0.637 |
PIM3 |
0.846 | 0.629 | -3 | 0.607 |
PRKD1 |
0.845 | 0.554 | -3 | 0.572 |
PKACB |
0.844 | 0.538 | -2 | 0.710 |
SGK1 |
0.843 | 0.758 | -3 | 0.856 |
MSK1 |
0.843 | 0.612 | -3 | 0.725 |
MSK2 |
0.843 | 0.672 | -3 | 0.739 |
PKACA |
0.842 | 0.571 | -2 | 0.667 |
AKT3 |
0.841 | 0.710 | -3 | 0.845 |
SBK |
0.840 | 0.799 | -3 | 0.866 |
SRPK3 |
0.839 | 0.634 | -3 | 0.765 |
P70S6KB |
0.838 | 0.632 | -3 | 0.660 |
NDR2 |
0.838 | 0.437 | -3 | 0.529 |
PKACG |
0.837 | 0.484 | -2 | 0.792 |
HIPK4 |
0.837 | 0.494 | 1 | 0.749 |
SGK3 |
0.836 | 0.624 | -3 | 0.671 |
CAMK1D |
0.836 | 0.716 | -3 | 0.750 |
PIM2 |
0.835 | 0.682 | -3 | 0.737 |
NDR1 |
0.834 | 0.503 | -3 | 0.565 |
AKT1 |
0.834 | 0.646 | -3 | 0.759 |
ICK |
0.834 | 0.625 | -3 | 0.618 |
CLK1 |
0.833 | 0.579 | -3 | 0.719 |
CAMK1B |
0.833 | 0.655 | -3 | 0.543 |
AMPKA2 |
0.832 | 0.553 | -3 | 0.577 |
P70S6K |
0.832 | 0.671 | -3 | 0.753 |
PKN3 |
0.832 | 0.542 | -3 | 0.580 |
CHK2 |
0.832 | 0.775 | -3 | 0.811 |
SIK |
0.832 | 0.586 | -3 | 0.646 |
MAPKAPK5 |
0.831 | 0.691 | -3 | 0.713 |
CLK4 |
0.831 | 0.570 | -3 | 0.717 |
AURC |
0.830 | 0.303 | -2 | 0.688 |
NUAK2 |
0.829 | 0.555 | -3 | 0.583 |
LATS2 |
0.829 | 0.374 | -5 | 0.793 |
PKG2 |
0.829 | 0.432 | -2 | 0.729 |
CAMK1A |
0.829 | 0.711 | -3 | 0.781 |
AMPKA1 |
0.828 | 0.495 | -3 | 0.521 |
SKMLCK |
0.828 | 0.446 | -2 | 0.874 |
MELK |
0.827 | 0.573 | -3 | 0.591 |
NUAK1 |
0.827 | 0.553 | -3 | 0.635 |
CLK2 |
0.827 | 0.549 | -3 | 0.750 |
MYLK4 |
0.826 | 0.518 | -2 | 0.784 |
CAMK2D |
0.826 | 0.436 | -3 | 0.509 |
TSSK1 |
0.825 | 0.428 | -3 | 0.503 |
DYRK1A |
0.824 | 0.538 | 1 | 0.679 |
BRSK1 |
0.823 | 0.511 | -3 | 0.631 |
CAMK1G |
0.823 | 0.620 | -3 | 0.693 |
CDC7 |
0.823 | 0.164 | 1 | 0.856 |
QSK |
0.822 | 0.439 | 4 | 0.826 |
CLK3 |
0.822 | 0.320 | 1 | 0.773 |
CAMLCK |
0.821 | 0.500 | -2 | 0.853 |
CAMK2A |
0.821 | 0.459 | 2 | 0.775 |
AURB |
0.821 | 0.293 | -2 | 0.679 |
PAK6 |
0.820 | 0.264 | -2 | 0.705 |
DCAMKL1 |
0.820 | 0.598 | -3 | 0.627 |
PKN2 |
0.819 | 0.422 | -3 | 0.519 |
PAK1 |
0.819 | 0.339 | -2 | 0.793 |
DAPK2 |
0.819 | 0.569 | -3 | 0.510 |
MAK |
0.819 | 0.548 | -2 | 0.805 |
CAMK4 |
0.818 | 0.448 | -3 | 0.539 |
MARK4 |
0.818 | 0.264 | 4 | 0.850 |
CAMK2B |
0.818 | 0.389 | 2 | 0.777 |
WNK1 |
0.817 | 0.284 | -2 | 0.892 |
COT |
0.816 | 0.038 | 2 | 0.814 |
MRCKB |
0.816 | 0.602 | -3 | 0.700 |
PKN1 |
0.815 | 0.603 | -3 | 0.723 |
PAK3 |
0.815 | 0.313 | -2 | 0.787 |
PKCD |
0.815 | 0.364 | 2 | 0.710 |
PKG1 |
0.815 | 0.506 | -2 | 0.643 |
TSSK2 |
0.814 | 0.332 | -5 | 0.885 |
DYRK2 |
0.814 | 0.326 | 1 | 0.646 |
HIPK2 |
0.814 | 0.356 | 1 | 0.546 |
MNK2 |
0.813 | 0.264 | -2 | 0.804 |
HIPK1 |
0.813 | 0.424 | 1 | 0.662 |
DYRK3 |
0.813 | 0.486 | 1 | 0.673 |
NIM1 |
0.812 | 0.305 | 3 | 0.796 |
BRSK2 |
0.812 | 0.380 | -3 | 0.548 |
IKKB |
0.812 | 0.090 | -2 | 0.758 |
CRIK |
0.811 | 0.672 | -3 | 0.778 |
CHK1 |
0.810 | 0.384 | -3 | 0.494 |
RAF1 |
0.810 | 0.172 | 1 | 0.878 |
LATS1 |
0.810 | 0.388 | -3 | 0.503 |
MOS |
0.809 | 0.093 | 1 | 0.878 |
MRCKA |
0.809 | 0.562 | -3 | 0.675 |
NIK |
0.809 | 0.439 | -3 | 0.434 |
MOK |
0.809 | 0.568 | 1 | 0.706 |
QIK |
0.808 | 0.359 | -3 | 0.493 |
PHKG1 |
0.808 | 0.400 | -3 | 0.554 |
TBK1 |
0.808 | 0.019 | 1 | 0.798 |
MNK1 |
0.807 | 0.274 | -2 | 0.819 |
MARK3 |
0.807 | 0.284 | 4 | 0.787 |
HIPK3 |
0.807 | 0.414 | 1 | 0.680 |
AURA |
0.806 | 0.249 | -2 | 0.634 |
MST4 |
0.806 | 0.167 | 2 | 0.792 |
PAK2 |
0.806 | 0.293 | -2 | 0.773 |
DCAMKL2 |
0.805 | 0.458 | -3 | 0.599 |
PRPK |
0.805 | -0.041 | -1 | 0.812 |
NLK |
0.805 | 0.128 | 1 | 0.790 |
SMMLCK |
0.805 | 0.545 | -3 | 0.611 |
PAK5 |
0.805 | 0.289 | -2 | 0.646 |
DAPK3 |
0.805 | 0.552 | -3 | 0.645 |
PAK4 |
0.804 | 0.278 | -2 | 0.648 |
ATR |
0.804 | 0.084 | 1 | 0.816 |
PKCB |
0.804 | 0.316 | 2 | 0.648 |
RIPK3 |
0.804 | 0.080 | 3 | 0.756 |
ROCK2 |
0.804 | 0.558 | -3 | 0.633 |
IKKE |
0.803 | -0.001 | 1 | 0.796 |
PDHK4 |
0.803 | -0.088 | 1 | 0.867 |
ERK5 |
0.803 | 0.074 | 1 | 0.811 |
MARK2 |
0.803 | 0.269 | 4 | 0.754 |
MARK1 |
0.802 | 0.307 | 4 | 0.802 |
DAPK1 |
0.802 | 0.546 | -3 | 0.676 |
RIPK1 |
0.802 | 0.195 | 1 | 0.842 |
WNK3 |
0.802 | 0.127 | 1 | 0.841 |
DMPK1 |
0.802 | 0.577 | -3 | 0.682 |
MTOR |
0.801 | -0.031 | 1 | 0.785 |
CAMK2G |
0.801 | -0.000 | 2 | 0.794 |
HUNK |
0.801 | 0.045 | 2 | 0.796 |
PHKG2 |
0.800 | 0.393 | -3 | 0.569 |
PKCG |
0.800 | 0.269 | 2 | 0.650 |
CHAK2 |
0.800 | 0.043 | -1 | 0.847 |
TGFBR2 |
0.799 | 0.065 | -2 | 0.742 |
BCKDK |
0.799 | -0.009 | -1 | 0.783 |
DYRK1B |
0.798 | 0.314 | 1 | 0.582 |
ULK2 |
0.798 | -0.110 | 2 | 0.751 |
PDHK1 |
0.798 | -0.076 | 1 | 0.871 |
PKCH |
0.798 | 0.308 | 2 | 0.640 |
GCN2 |
0.797 | -0.124 | 2 | 0.769 |
PKCA |
0.797 | 0.237 | 2 | 0.645 |
SNRK |
0.797 | 0.307 | 2 | 0.654 |
DYRK4 |
0.796 | 0.262 | 1 | 0.554 |
PKCT |
0.796 | 0.369 | 2 | 0.651 |
BMPR2 |
0.796 | -0.129 | -2 | 0.860 |
DSTYK |
0.796 | -0.106 | 2 | 0.831 |
ROCK1 |
0.796 | 0.554 | -3 | 0.674 |
GRK6 |
0.796 | 0.043 | 1 | 0.845 |
SSTK |
0.795 | 0.266 | 4 | 0.804 |
GRK5 |
0.795 | -0.067 | -3 | 0.279 |
FAM20C |
0.795 | 0.067 | 2 | 0.663 |
MASTL |
0.794 | 0.034 | -2 | 0.815 |
IKKA |
0.794 | -0.033 | -2 | 0.752 |
PKCZ |
0.794 | 0.230 | 2 | 0.712 |
GRK1 |
0.794 | 0.013 | -2 | 0.826 |
PKCE |
0.793 | 0.396 | 2 | 0.638 |
PASK |
0.791 | 0.425 | -3 | 0.542 |
TTBK2 |
0.790 | -0.036 | 2 | 0.691 |
ATM |
0.790 | 0.043 | 1 | 0.758 |
NEK7 |
0.790 | -0.131 | -3 | 0.249 |
CDK7 |
0.789 | 0.055 | 1 | 0.597 |
NEK9 |
0.788 | -0.078 | 2 | 0.785 |
IRE1 |
0.788 | 0.057 | 1 | 0.809 |
WNK4 |
0.787 | 0.234 | -2 | 0.877 |
DLK |
0.787 | 0.090 | 1 | 0.839 |
ULK1 |
0.787 | -0.155 | -3 | 0.227 |
NEK6 |
0.786 | -0.121 | -2 | 0.830 |
PKCI |
0.786 | 0.281 | 2 | 0.669 |
MLK1 |
0.785 | -0.101 | 2 | 0.739 |
KIS |
0.785 | -0.032 | 1 | 0.633 |
GRK4 |
0.785 | -0.101 | -2 | 0.824 |
PKR |
0.785 | 0.099 | 1 | 0.856 |
NEK2 |
0.784 | -0.030 | 2 | 0.759 |
MLK2 |
0.784 | -0.068 | 2 | 0.767 |
ANKRD3 |
0.783 | 0.005 | 1 | 0.878 |
DNAPK |
0.783 | 0.036 | 1 | 0.719 |
BMPR1B |
0.782 | 0.009 | 1 | 0.802 |
CK1E |
0.781 | -0.065 | -3 | 0.151 |
CHAK1 |
0.781 | 0.021 | 2 | 0.753 |
SMG1 |
0.781 | -0.013 | 1 | 0.767 |
TGFBR1 |
0.780 | -0.035 | -2 | 0.757 |
ALK4 |
0.780 | -0.033 | -2 | 0.787 |
MEK1 |
0.780 | 0.000 | 2 | 0.811 |
PLK1 |
0.779 | -0.043 | -2 | 0.761 |
PDK1 |
0.779 | 0.365 | 1 | 0.828 |
CDK8 |
0.779 | -0.035 | 1 | 0.581 |
DRAK1 |
0.779 | 0.129 | 1 | 0.767 |
JNK2 |
0.779 | 0.026 | 1 | 0.548 |
GRK7 |
0.778 | 0.041 | 1 | 0.764 |
VRK2 |
0.778 | -0.027 | 1 | 0.866 |
IRE2 |
0.778 | 0.012 | 2 | 0.680 |
CK1G1 |
0.777 | -0.074 | -3 | 0.155 |
IRAK4 |
0.777 | 0.083 | 1 | 0.831 |
P38A |
0.776 | 0.027 | 1 | 0.655 |
CDK19 |
0.776 | -0.024 | 1 | 0.540 |
CK1A2 |
0.774 | -0.064 | -3 | 0.146 |
ALK2 |
0.774 | -0.023 | -2 | 0.771 |
CDK14 |
0.774 | 0.112 | 1 | 0.571 |
CK1D |
0.774 | -0.072 | -3 | 0.124 |
MPSK1 |
0.773 | 0.061 | 1 | 0.773 |
CDK10 |
0.773 | 0.152 | 1 | 0.553 |
PLK3 |
0.773 | -0.082 | 2 | 0.763 |
JNK3 |
0.773 | -0.007 | 1 | 0.584 |
PLK4 |
0.772 | -0.026 | 2 | 0.622 |
CDK18 |
0.772 | 0.013 | 1 | 0.520 |
YSK4 |
0.772 | -0.080 | 1 | 0.813 |
MLK3 |
0.771 | -0.076 | 2 | 0.661 |
CDK9 |
0.771 | 0.010 | 1 | 0.584 |
TLK2 |
0.771 | -0.079 | 1 | 0.799 |
BRAF |
0.771 | 0.034 | -4 | 0.790 |
CDK13 |
0.770 | -0.023 | 1 | 0.572 |
P38B |
0.770 | 0.008 | 1 | 0.582 |
ACVR2B |
0.769 | -0.068 | -2 | 0.749 |
GRK2 |
0.769 | -0.037 | -2 | 0.727 |
MST3 |
0.769 | 0.066 | 2 | 0.770 |
IRAK1 |
0.769 | -0.006 | -1 | 0.761 |
CDK12 |
0.768 | 0.012 | 1 | 0.546 |
PERK |
0.768 | -0.076 | -2 | 0.795 |
ACVR2A |
0.767 | -0.069 | -2 | 0.729 |
PRP4 |
0.767 | -0.065 | -3 | 0.236 |
NEK5 |
0.766 | -0.056 | 1 | 0.849 |
ERK1 |
0.766 | -0.009 | 1 | 0.569 |
MEK5 |
0.766 | -0.013 | 2 | 0.784 |
TTBK1 |
0.766 | -0.066 | 2 | 0.612 |
LKB1 |
0.766 | 0.005 | -3 | 0.261 |
BUB1 |
0.766 | 0.172 | -5 | 0.799 |
CDK5 |
0.765 | -0.015 | 1 | 0.611 |
MLK4 |
0.765 | -0.110 | 2 | 0.655 |
HRI |
0.765 | -0.100 | -2 | 0.807 |
PBK |
0.765 | 0.140 | 1 | 0.767 |
LOK |
0.764 | 0.138 | -2 | 0.793 |
BMPR1A |
0.764 | -0.023 | 1 | 0.781 |
ERK2 |
0.763 | -0.023 | 1 | 0.612 |
CAMKK2 |
0.763 | -0.016 | -2 | 0.777 |
TLK1 |
0.763 | -0.075 | -2 | 0.797 |
P38G |
0.762 | -0.012 | 1 | 0.460 |
PINK1 |
0.762 | -0.114 | 1 | 0.783 |
MEKK1 |
0.762 | -0.109 | 1 | 0.832 |
MEKK2 |
0.762 | -0.055 | 2 | 0.753 |
TAO3 |
0.762 | 0.042 | 1 | 0.813 |
GAK |
0.762 | 0.060 | 1 | 0.833 |
MEKK3 |
0.761 | -0.091 | 1 | 0.829 |
CAMKK1 |
0.760 | -0.095 | -2 | 0.776 |
GRK3 |
0.760 | -0.040 | -2 | 0.685 |
CDK17 |
0.759 | -0.020 | 1 | 0.461 |
GSK3B |
0.759 | 0.013 | 4 | 0.481 |
ZAK |
0.758 | -0.102 | 1 | 0.806 |
NEK4 |
0.758 | -0.017 | 1 | 0.835 |
MEKK6 |
0.758 | 0.068 | 1 | 0.820 |
HPK1 |
0.758 | 0.129 | 1 | 0.829 |
NEK8 |
0.758 | 0.033 | 2 | 0.755 |
TAO2 |
0.757 | 0.030 | 2 | 0.784 |
CDK1 |
0.757 | -0.041 | 1 | 0.546 |
NEK11 |
0.756 | -0.053 | 1 | 0.819 |
LRRK2 |
0.756 | 0.134 | 2 | 0.797 |
KHS1 |
0.756 | 0.125 | 1 | 0.833 |
TNIK |
0.756 | 0.055 | 3 | 0.836 |
HGK |
0.755 | 0.020 | 3 | 0.831 |
GCK |
0.755 | 0.055 | 1 | 0.830 |
NEK1 |
0.754 | -0.011 | 1 | 0.838 |
KHS2 |
0.754 | 0.139 | 1 | 0.835 |
MINK |
0.753 | 0.018 | 1 | 0.840 |
GSK3A |
0.753 | 0.005 | 4 | 0.489 |
SLK |
0.753 | 0.047 | -2 | 0.744 |
CDK2 |
0.753 | -0.071 | 1 | 0.635 |
MAP3K15 |
0.752 | -0.003 | 1 | 0.793 |
CDK4 |
0.752 | 0.060 | 1 | 0.528 |
P38D |
0.752 | -0.024 | 1 | 0.481 |
CK2A2 |
0.752 | 0.001 | 1 | 0.718 |
HASPIN |
0.752 | 0.131 | -1 | 0.723 |
TAK1 |
0.751 | 0.034 | 1 | 0.842 |
VRK1 |
0.751 | 0.011 | 2 | 0.784 |
STK33 |
0.750 | -0.017 | 2 | 0.601 |
ERK7 |
0.750 | -0.017 | 2 | 0.461 |
RIPK2 |
0.749 | 0.005 | 1 | 0.780 |
CDK16 |
0.749 | -0.020 | 1 | 0.480 |
PLK2 |
0.748 | -0.084 | -3 | 0.218 |
CDK3 |
0.748 | -0.023 | 1 | 0.482 |
JNK1 |
0.748 | -0.025 | 1 | 0.525 |
MST2 |
0.747 | -0.110 | 1 | 0.843 |
NEK3 |
0.747 | -0.018 | 1 | 0.797 |
MEK2 |
0.746 | -0.098 | 2 | 0.785 |
EEF2K |
0.746 | -0.049 | 3 | 0.809 |
YSK1 |
0.745 | 0.011 | 2 | 0.748 |
MST1 |
0.743 | -0.078 | 1 | 0.832 |
CK2A1 |
0.741 | -0.009 | 1 | 0.696 |
PDHK3_TYR |
0.741 | 0.079 | 4 | 0.903 |
CK1A |
0.740 | -0.089 | -3 | 0.091 |
CDK6 |
0.740 | -0.019 | 1 | 0.551 |
YANK3 |
0.740 | 0.015 | 2 | 0.408 |
LIMK2_TYR |
0.737 | 0.182 | -3 | 0.349 |
BIKE |
0.733 | 0.018 | 1 | 0.709 |
TESK1_TYR |
0.733 | 0.063 | 3 | 0.870 |
TTK |
0.731 | -0.023 | -2 | 0.774 |
MAP2K4_TYR |
0.731 | 0.081 | -1 | 0.817 |
MYO3B |
0.731 | -0.005 | 2 | 0.764 |
TAO1 |
0.730 | 0.030 | 1 | 0.764 |
MAP2K7_TYR |
0.729 | -0.017 | 2 | 0.832 |
TNK2 |
0.729 | 0.114 | 3 | 0.773 |
PKMYT1_TYR |
0.728 | 0.004 | 3 | 0.844 |
PINK1_TYR |
0.727 | 0.121 | 1 | 0.840 |
ASK1 |
0.727 | -0.064 | 1 | 0.780 |
RET |
0.726 | 0.035 | 1 | 0.830 |
EPHA6 |
0.726 | 0.023 | -1 | 0.786 |
MAP2K6_TYR |
0.726 | -0.037 | -1 | 0.812 |
DDR1 |
0.725 | 0.074 | 4 | 0.814 |
EPHB4 |
0.724 | 0.000 | -1 | 0.793 |
PDHK4_TYR |
0.724 | -0.090 | 2 | 0.848 |
OSR1 |
0.724 | -0.103 | 2 | 0.752 |
MYO3A |
0.722 | -0.041 | 1 | 0.818 |
LIMK1_TYR |
0.722 | 0.014 | 2 | 0.816 |
TNK1 |
0.721 | 0.105 | 3 | 0.783 |
BMPR2_TYR |
0.721 | -0.072 | -1 | 0.778 |
CK1G3 |
0.721 | -0.093 | -3 | 0.080 |
PDHK1_TYR |
0.721 | -0.099 | -1 | 0.816 |
ALPHAK3 |
0.721 | -0.069 | -1 | 0.692 |
TYRO3 |
0.720 | -0.034 | 3 | 0.799 |
ROS1 |
0.720 | -0.002 | 3 | 0.788 |
MST1R |
0.720 | -0.012 | 3 | 0.817 |
AAK1 |
0.719 | 0.035 | 1 | 0.602 |
TYK2 |
0.718 | -0.072 | 1 | 0.836 |
ABL2 |
0.717 | -0.010 | -1 | 0.771 |
AXL |
0.717 | 0.024 | 3 | 0.793 |
DDR2 |
0.717 | 0.139 | 3 | 0.752 |
YES1 |
0.716 | -0.043 | -1 | 0.822 |
JAK2 |
0.715 | -0.095 | 1 | 0.830 |
NEK10_TYR |
0.715 | 0.061 | 1 | 0.716 |
SRMS |
0.714 | -0.054 | 1 | 0.868 |
ABL1 |
0.714 | -0.027 | -1 | 0.772 |
TXK |
0.714 | -0.019 | 1 | 0.842 |
EPHB3 |
0.714 | -0.037 | -1 | 0.782 |
CSF1R |
0.713 | -0.082 | 3 | 0.798 |
TNNI3K_TYR |
0.713 | 0.010 | 1 | 0.839 |
EPHB1 |
0.713 | -0.057 | 1 | 0.869 |
MERTK |
0.712 | -0.026 | 3 | 0.793 |
STLK3 |
0.712 | -0.134 | 1 | 0.780 |
FGR |
0.712 | -0.078 | 1 | 0.864 |
FER |
0.711 | -0.099 | 1 | 0.876 |
EPHA4 |
0.711 | -0.061 | 2 | 0.764 |
EPHB2 |
0.711 | -0.056 | -1 | 0.773 |
ITK |
0.710 | -0.049 | -1 | 0.773 |
INSRR |
0.710 | -0.043 | 3 | 0.763 |
LCK |
0.710 | -0.041 | -1 | 0.777 |
HCK |
0.709 | -0.087 | -1 | 0.782 |
EPHA1 |
0.709 | 0.008 | 3 | 0.781 |
JAK3 |
0.709 | -0.085 | 1 | 0.802 |
PDGFRB |
0.708 | -0.054 | 3 | 0.809 |
BLK |
0.708 | -0.024 | -1 | 0.777 |
BTK |
0.707 | -0.076 | -1 | 0.769 |
LTK |
0.707 | 0.005 | 3 | 0.758 |
JAK1 |
0.707 | -0.031 | 1 | 0.788 |
FGFR2 |
0.706 | -0.072 | 3 | 0.805 |
BMX |
0.706 | -0.036 | -1 | 0.688 |
FLT3 |
0.705 | -0.057 | 3 | 0.796 |
EPHA7 |
0.705 | -0.042 | 2 | 0.760 |
TEK |
0.705 | -0.079 | 3 | 0.746 |
TEC |
0.704 | -0.045 | -1 | 0.739 |
ALK |
0.704 | -0.029 | 3 | 0.736 |
KDR |
0.704 | -0.049 | 3 | 0.773 |
FGFR1 |
0.704 | -0.089 | 3 | 0.787 |
PTK2B |
0.701 | -0.019 | -1 | 0.781 |
PDGFRA |
0.701 | -0.088 | 3 | 0.801 |
EPHA3 |
0.701 | -0.075 | 2 | 0.739 |
KIT |
0.701 | -0.131 | 3 | 0.794 |
MET |
0.699 | -0.093 | 3 | 0.791 |
NTRK1 |
0.698 | -0.121 | -1 | 0.768 |
PTK6 |
0.698 | -0.118 | -1 | 0.720 |
WEE1_TYR |
0.698 | -0.060 | -1 | 0.728 |
YANK2 |
0.698 | -0.057 | 2 | 0.419 |
FYN |
0.697 | -0.073 | -1 | 0.740 |
FRK |
0.696 | -0.089 | -1 | 0.795 |
EPHA5 |
0.696 | -0.061 | 2 | 0.750 |
INSR |
0.694 | -0.100 | 3 | 0.740 |
NTRK2 |
0.694 | -0.132 | 3 | 0.760 |
LYN |
0.692 | -0.112 | 3 | 0.723 |
ERBB2 |
0.692 | -0.139 | 1 | 0.773 |
NTRK3 |
0.692 | -0.112 | -1 | 0.717 |
FGFR3 |
0.692 | -0.112 | 3 | 0.778 |
EPHA8 |
0.690 | -0.087 | -1 | 0.731 |
MATK |
0.689 | -0.102 | -1 | 0.692 |
FLT4 |
0.689 | -0.121 | 3 | 0.761 |
CSK |
0.689 | -0.092 | 2 | 0.765 |
SRC |
0.688 | -0.099 | -1 | 0.753 |
FLT1 |
0.687 | -0.145 | -1 | 0.735 |
CK1G2 |
0.687 | -0.103 | -3 | 0.115 |
PTK2 |
0.682 | -0.064 | -1 | 0.672 |
EGFR |
0.681 | -0.118 | 1 | 0.681 |
FGFR4 |
0.681 | -0.117 | -1 | 0.705 |
EPHA2 |
0.678 | -0.102 | -1 | 0.689 |
IGF1R |
0.676 | -0.113 | 3 | 0.680 |
SYK |
0.674 | -0.110 | -1 | 0.649 |
MUSK |
0.671 | -0.124 | 1 | 0.677 |
ERBB4 |
0.669 | -0.108 | 1 | 0.693 |
FES |
0.668 | -0.124 | -1 | 0.670 |
ZAP70 |
0.651 | -0.104 | -1 | 0.585 |