Motif 332 (n=227)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | T2547 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A0C4DFX4 | None | S2548 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A5F9ZHR4 | AQP4 | S331 | psp | Aquaporin-4 | None |
| A4D2P6 | GRID2IP | S264 | ochoa | Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1) | Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. {ECO:0000250}. |
| A6NC98 | CCDC88B | S597 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A6ND36 | FAM83G | S610 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| A7MBM2 | DISP2 | S1173 | ochoa | Protein dispatched homolog 2 | None |
| A8MVW0 | FAM171A2 | S789 | ochoa | Protein FAM171A2 | None |
| B0I1T2 | MYO1G | S992 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
| F8WAN1 | SPECC1L-ADORA2A | S832 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| O00562 | PITPNM1 | S593 | ochoa | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
| O14744 | PRMT5 | S103 | psp | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
| O15014 | ZNF609 | S413 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15018 | PDZD2 | S2374 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15075 | DCLK1 | S307 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O15164 | TRIM24 | S687 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15409 | FOXP2 | S330 | ochoa | Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. |
| O43318 | MAP3K7 | S439 | ochoa|psp | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
| O43379 | WDR62 | S1228 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O60240 | PLIN1 | S81 | ochoa | Perilipin-1 (Lipid droplet-associated protein) | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}. |
| O60242 | ADGRB3 | S1417 | ochoa | Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) | Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). {ECO:0000250|UniProtKB:Q80ZF8, ECO:0000269|PubMed:24567399}. |
| O60307 | MAST3 | S935 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O60331 | PIP5K1C | T553 | psp | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). {ECO:0000250|UniProtKB:O70161, ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:12422219, ECO:0000269|PubMed:12847086, ECO:0000269|PubMed:17261850, ECO:0000269|PubMed:17635937, ECO:0000269|PubMed:22942276, ECO:0000305|PubMed:19889969}. |
| O60381 | HBP1 | S380 | ochoa|psp | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| O60749 | SNX2 | S185 | ochoa | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}. |
| O75037 | KIF21B | S510 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75140 | DEPDC5 | S1530 | ochoa|psp | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75175 | CNOT3 | S291 | ochoa | CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}. |
| O75363 | BCAS1 | S451 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75376 | NCOR1 | S88 | ochoa|psp | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75400 | PRPF40A | S34 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O94875 | SORBS2 | S230 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95071 | UBR5 | S1549 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| P02538 | KRT6A | S19 | psp | Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5) | Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. {ECO:0000250|UniProtKB:P50446}. |
| P07196 | NEFL | S58 | ochoa | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08551}. |
| P08151 | GLI1 | S560 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P10070 | GLI2 | S808 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10070 | GLI2 | S809 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10070 | GLI2 | S824 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10070 | GLI2 | S836 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10071 | GLI3 | S849 | ochoa|psp | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] | Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}. |
| P10071 | GLI3 | S865 | ochoa|psp | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] | Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}. |
| P10071 | GLI3 | S877 | psp | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] | Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}. |
| P10109 | FDX1 | S61 | ochoa | Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin) | Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}. |
| P12757 | SKIL | S490 | ochoa | Ski-like protein (Ski-related oncogene) (Ski-related protein) | May have regulatory role in cell division or differentiation in response to extracellular signals. |
| P13569 | CFTR | S737 | ochoa|psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
| P15036 | ETS2 | S246 | psp | Protein C-ets-2 | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}. |
| P15036 | ETS2 | S310 | ochoa|psp | Protein C-ets-2 | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}. |
| P15104 | GLUL | S322 | psp | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) | Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:16267323, PubMed:30158707, PubMed:36289327). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351). Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (PubMed:36289327). {ECO:0000250|UniProtKB:P15105, ECO:0000269|PubMed:16267323, ECO:0000269|PubMed:18662667, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:30158707, ECO:0000269|PubMed:36289327}. |
| P18615 | NELFE | S51 | ochoa|psp | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P22735 | TGM1 | S82 | psp | Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). {ECO:0000269|PubMed:26220141}. |
| P23677 | ITPKA | S121 | ochoa | Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO:0000269|PubMed:1847047}. |
| P23921 | RRM1 | S631 | ochoa|psp | Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
| P25054 | APC | S2374 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P28290 | ITPRID2 | S207 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28290 | ITPRID2 | S270 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P35568 | IRS1 | S413 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P42695 | NCAPD3 | S517 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P49238 | CX3CR1 | S336 | ochoa | CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMK-BRL1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28) | Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:12055230, PubMed:23125415, PubMed:9390561, PubMed:9782118). CX3CR1-CX3CL1 signaling mediates cell migratory functions (By similarity). Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (By similarity). Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (By similarity). Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (By similarity). Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (By similarity). Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:14581400, PubMed:18971423). Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (By similarity). Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (By similarity). Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (By similarity). Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (By similarity). Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (By similarity). Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (By similarity). Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (PubMed:29326275). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (PubMed:20974991). {ECO:0000250|UniProtKB:Q9Z0D9, ECO:0000269|PubMed:12055230, ECO:0000269|PubMed:14581400, ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:20974991, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:29326275, ECO:0000269|PubMed:9390561, ECO:0000269|PubMed:9782118}.; FUNCTION: [Isoform 1]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein. {ECO:0000269|PubMed:14607932, ECO:0000269|PubMed:9726990}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932). May have more potent HIV-1 coreceptothr activity than isoform 1 (PubMed:14607932). {ECO:0000269|PubMed:14607932}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932). May have more potent HIV-1 coreceptor activity than isoform 1 (PubMed:14607932). {ECO:0000269|PubMed:14607932}. |
| P51659 | HSD17B4 | S318 | ochoa|psp | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P51957 | NEK4 | S639 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P52179 | MYOM1 | S65 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54296 | MYOM2 | S58 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54829 | PTPN5 | S245 | psp | Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) | May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000269|PubMed:21777200}. |
| P98174 | FGD1 | S48 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| P98175 | RBM10 | S687 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q02952 | AKAP12 | S696 | ochoa|psp | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03111 | MLLT1 | S319 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q07001 | CHRND | S379 | ochoa | Acetylcholine receptor subunit delta | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:27375219}. |
| Q07157 | TJP1 | S175 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07889 | SOS1 | S401 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q12899 | TRIM26 | S47 | ochoa | Tripartite motif-containing protein 26 (EC 2.3.2.27) (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173) | E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Also plays a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA (PubMed:29610152, PubMed:36232914). Promotes nuclear IRF3 ubiquitination and proteasomal degradation (PubMed:25763818). Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling (PubMed:34017102). In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation (PubMed:34732716). Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein (PubMed:23452852). Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (PubMed:29203640). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity). Inhibits directly hepatitis B virus replication by mediating HBX ubiquitination and subsequent degradation (PubMed:35872575). {ECO:0000250|UniProtKB:Q99PN3, ECO:0000269|PubMed:23452852, ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:29203640, ECO:0000269|PubMed:29610152, ECO:0000269|PubMed:34017102, ECO:0000269|PubMed:34732716, ECO:0000269|PubMed:35872575, ECO:0000269|PubMed:36232914}.; FUNCTION: (Microbial infection) Promotes herpes simplex virus type 2/HHV-2 infection in vaginal epithelial cells by decreasing the nuclear localization of IRF3, the primary mediator of type I interferon activation. {ECO:0000269|PubMed:33419081}. |
| Q13029 | PRDM2 | S739 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13427 | PPIG | S544 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13469 | NFATC2 | S255 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13480 | GAB1 | S304 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13563 | PKD2 | S829 | ochoa|psp | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q13946 | PDE7A | S113 | ochoa | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912). {ECO:0000269|PubMed:19350606, ECO:0000269|PubMed:8389765, ECO:0000269|PubMed:9195912}. |
| Q14004 | CDK13 | S437 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14203 | DCTN1 | S19 | psp | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14244 | MAP7 | S183 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14524 | SCN5A | S571 | psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14940 | SLC9A5 | S853 | psp | Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:10692428, PubMed:19276089, PubMed:24936055, PubMed:9933641). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:21551074, PubMed:24006492). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055). {ECO:0000269|PubMed:10692428, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24006492, ECO:0000269|PubMed:24936055, ECO:0000269|PubMed:9933641}. |
| Q14980 | NUMA1 | S2047 | ochoa|psp | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15057 | ACAP2 | S578 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q16186 | ADRM1 | S213 | ochoa | Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}. |
| Q2M2I3 | FAM83E | S319 | ochoa | Protein FAM83E | May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}. |
| Q2PPJ7 | RALGAPA2 | S373 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q4G0A6 | MINDY4 | S233 | ochoa | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4) | Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000250|UniProtKB:Q8NBR6}. |
| Q59EK9 | RUNDC3A | S366 | ochoa | RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) | May act as an effector of RAP2A in neuronal cells. {ECO:0000250}. |
| Q5JTV8 | TOR1AIP1 | S254 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5S007 | LRRK2 | S971 | ochoa | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5SYE7 | NHSL1 | S639 | ochoa | NHS-like protein 1 | None |
| Q5T011 | SZT2 | S1642 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T200 | ZC3H13 | S238 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T200 | ZC3H13 | S1279 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T8I3 | EEIG2 | S239 | ochoa | EEIG family member 2 (EEIG2) | None |
| Q5TGY3 | AHDC1 | S1058 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VU43 | PDE4DIP | S726 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VUA4 | ZNF318 | S40 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VZ89 | DENND4C | S1325 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q68CZ2 | TNS3 | S941 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68D10 | SPTY2D1 | S470 | ochoa | Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1) | Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026). {ECO:0000250|UniProtKB:E1BUG7, ECO:0000269|PubMed:23378026}. |
| Q69YH5 | CDCA2 | S91 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q69YH5 | CDCA2 | S977 | ochoa|psp | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q69YN2 | CWF19L1 | S144 | ochoa | CWF19-like protein 1 (C19L1) | None |
| Q69YQ0 | SPECC1L | S832 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6NSJ2 | PHLDB3 | S412 | ochoa | Pleckstrin homology-like domain family B member 3 | None |
| Q6PEV8 | FAM199X | S316 | ochoa | Protein FAM199X | None |
| Q6PFW1 | PPIP5K1 | S1006 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6PJF5 | RHBDF2 | S239 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6R327 | RICTOR | S1035 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6UUV7 | CRTC3 | S368 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6UX68 | XKR5 | S622 | ochoa | XK-related protein 5 | None |
| Q6V0I7 | FAT4 | S4686 | ochoa | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}. |
| Q6WKZ4 | RAB11FIP1 | S435 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZNL6 | FGD5 | S699 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZRS2 | SRCAP | T2724 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRS2 | SRCAP | S2725 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZVD8 | PHLPP2 | S1210 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| Q71F56 | MED13L | S2083 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q76N89 | HECW1 | S937 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Q7LBC6 | KDM3B | S727 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z5H3 | ARHGAP22 | S476 | psp | Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
| Q7Z6E9 | RBBP6 | S1462 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86X51 | EZHIP | S363 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86XD5 | FAM131B | S47 | ochoa | Protein FAM131B | None |
| Q86Z02 | HIPK1 | S965 | ochoa | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q8IW93 | ARHGEF19 | S197 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IWU9 | TPH2 | S19 | psp | Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2) | None |
| Q8IWX8 | CHERP | S813 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IWX8 | CHERP | S815 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IYB3 | SRRM1 | S207 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N103 | TAGAP | S68 | ochoa | T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) | May function as a GTPase-activating protein and may play important roles during T-cell activation. {ECO:0000269|PubMed:15177553}. |
| Q8N228 | SCML4 | S274 | ochoa | Sex comb on midleg-like protein 4 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q8N3C7 | CLIP4 | S581 | ochoa | CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) | None |
| Q8NB90 | AFG2A | S34 | ochoa | ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024, PubMed:38554706). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UMC0, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q8NCN4 | RNF169 | S368 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NEY1 | NAV1 | S452 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEY1 | NAV1 | S695 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S2068 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NF50 | DOCK8 | S902 | ochoa | Dedicator of cytokinesis protein 8 | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}. |
| Q8NFC6 | BOD1L1 | S1701 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TC07 | TBC1D15 | S70 | ochoa | TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) | Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}. |
| Q8TES7 | FBF1 | S142 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8TES7 | FBF1 | S143 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8TF76 | HASPIN | S430 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WTQ7 | GRK7 | S36 | psp | Rhodopsin kinase GRK7 (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7) | Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). {ECO:0000269|PubMed:15946941}. |
| Q8WWI1 | LMO7 | Y804 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXI9 | GATAD2B | S313 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q92835 | INPP5D | S170 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q92859 | NEO1 | S1299 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q96D31 | ORAI1 | S34 | psp | Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) | Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (Probable) (PubMed:16645049, PubMed:16733527, PubMed:16807233, PubMed:16921383, PubMed:19249086, PubMed:19706554, PubMed:23307288, PubMed:26956484, PubMed:28219928). Assembles with ORAI2 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription (PubMed:16582901, PubMed:17442569, PubMed:19182790, PubMed:20354224, PubMed:22641696, PubMed:26221052, PubMed:32415068, PubMed:33941685). Assembles with ORAI3 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively (PubMed:19622606, PubMed:32415068). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (By similarity) (PubMed:20887894). {ECO:0000250|UniProtKB:Q8BWG9, ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:16921383, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:20354224, ECO:0000269|PubMed:20887894, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:26956484, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068, ECO:0000269|PubMed:33941685, ECO:0000305|PubMed:16766533}.; FUNCTION: [Isoform alpha]: Pore-forming subunit of both CRAC and ARC channels. Couples Ca(2+) influx to NFAT-mediated transcriptional responses. {ECO:0000269|PubMed:16921383, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:33941685}.; FUNCTION: [Isoform beta]: Pore-forming subunit of CRAC channels exclusively. {ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:33941685}. |
| Q96DR7 | ARHGEF26 | S22 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96GS4 | BORCS6 | T196 | ochoa | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}. |
| Q96HP0 | DOCK6 | S41 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96J02 | ITCH | S217 | ochoa | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) | Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11046148, PubMed:14602072, PubMed:15051726, PubMed:16387660, PubMed:17028573, PubMed:18718448, PubMed:18718449, PubMed:19116316, PubMed:19592251, PubMed:19881509, PubMed:20068034, PubMed:20392206, PubMed:20491914, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885, PubMed:34927784). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Together with UBR5, involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP: catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP (PubMed:20068034, PubMed:29378950). ITCH synthesizes 'Lys-63'-linked chains, while UBR5 is branching multiple 'Lys-48'-linked chains of substrate initially modified (PubMed:29378950). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). {ECO:0000250|UniProtKB:Q8C863, ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:15051726, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17028573, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:18718448, ECO:0000269|PubMed:18718449, ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:19131965, ECO:0000269|PubMed:19592251, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:20491914, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:30328013}. |
| Q96JQ2 | CLMN | S905 | ochoa | Calmin (Calponin-like transmembrane domain protein) | None |
| Q96K30 | RITA1 | S199 | ochoa | RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein) | Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}. |
| Q96L34 | MARK4 | S423 | ochoa | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) | Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}. |
| Q96N46 | TTC14 | S525 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96PX1 | RNF157 | S660 | psp | E3 ubiquitin ligase RNF157 (EC 2.3.2.27) (RING finger protein 157) (RING-type E3 ubiquitin transferase RNF157) | E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). {ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:28655764}. |
| Q96QB1 | DLC1 | S766 | psp | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96RU2 | USP28 | S490 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q96RV3 | PCNX1 | S2152 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96T83 | SLC9A7 | S693 | ochoa | Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7) | Golgi Na(+), K(+)/(H+) antiporter. Mediates the electoneutral influx of Na(+) or K(+) in exchange for H(+). May contribute to the regulation of Golgi apparatus volume and pH. {ECO:0000269|PubMed:11279194, ECO:0000269|PubMed:30335141}. |
| Q99490 | AGAP2 | S927 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99502 | EYA1 | S299 | psp | Protein phosphatase EYA1 (EC 3.1.3.16) (EC 3.1.3.48) (Eyes absent homolog 1) | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Also has phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity). {ECO:0000250|UniProtKB:P97767, ECO:0000269|PubMed:19234442}. |
| Q99836 | MYD88 | S34 | ochoa | Myeloid differentiation primary response protein MyD88 | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825, PubMed:37971847). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:19506249, PubMed:24316379). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). {ECO:0000250|UniProtKB:P22366, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:24316379, ECO:0000269|PubMed:33718825, ECO:0000269|PubMed:37971847, ECO:0000269|PubMed:9013863}. |
| Q99856 | ARID3A | S353 | ochoa | AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1) | Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}. |
| Q9BSW7 | SYT17 | S110 | ochoa | Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII) | Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9BUJ2 | HNRNPUL1 | S748 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) | Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}. |
| Q9BW04 | SARG | S131 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BXF6 | RAB11FIP5 | S482 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BY89 | KIAA1671 | S1574 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZ71 | PITPNM3 | S295 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
| Q9BZ72 | PITPNM2 | S872 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9C0D6 | FHDC1 | S949 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9GZU3 | TMEM39B | S47 | ochoa | Transmembrane protein 39B | May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. {ECO:0000250|UniProtKB:Q7ZW11}. |
| Q9H1D0 | TRPV6 | S732 | psp | Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) | Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}. |
| Q9H329 | EPB41L4B | S423 | ochoa | Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}. |
| Q9H6A9 | PCNX3 | S443 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6B4 | CLMP | S319 | ochoa | CXADR-like membrane protein (Adipocyte adhesion molecule) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein) | May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. {ECO:0000269|PubMed:14573622, ECO:0000269|PubMed:15563274, ECO:0000269|PubMed:22155368}. |
| Q9HB07 | MYG1 | S39 | ochoa | MYG1 exonuclease (EC 3.1.-.-) | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}. |
| Q9HCD5 | NCOA5 | S529 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCD6 | TANC2 | S35 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NSK0 | KLC4 | S590 | ochoa|psp | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NTI5 | PDS5B | S1358 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NV58 | RNF19A | S631 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
| Q9NXD2 | MTMR10 | S751 | ochoa | Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) | None |
| Q9NXR1 | NDE1 | S306 | ochoa|psp | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
| Q9NYF3 | FAM53C | S232 | ochoa | Protein FAM53C | None |
| Q9NZM5 | NOP53 | S29 | ochoa | Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) | Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081). {ECO:0000269|PubMed:15355975, ECO:0000269|PubMed:16971513, ECO:0000269|PubMed:21167305, ECO:0000269|PubMed:21741933, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:24556985, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081, ECO:0000269|PubMed:27829214}. |
| Q9P0L2 | MARK1 | S423 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9P0U3 | SENP1 | S126 | ochoa | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}. |
| Q9P266 | JCAD | S980 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P270 | SLAIN2 | T313 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2D3 | HEATR5B | S1564 | ochoa | HEAT repeat-containing protein 5B | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| Q9UF83 | None | S494 | ochoa | Uncharacterized protein DKFZp434B061 | None |
| Q9UHB6 | LIMA1 | S225 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB7 | AFF4 | S155 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHI6 | DDX20 | S743 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9ULC8 | ZDHHC8 | S337 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULC8 | ZDHHC8 | S642 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULL1 | PLEKHG1 | S610 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULL8 | SHROOM4 | S378 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9ULV3 | CIZ1 | S198 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UNH5 | CDC14A | S483 | ochoa | Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}. |
| Q9UPQ3 | AGAP1 | S605 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1) | GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. |
| Q9UPQ9 | TNRC6B | S592 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UQ35 | SRRM2 | S780 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S817 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1691 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1727 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQD0 | SCN8A | S641 | psp | Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) | Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed:36696443, PubMed:36823201). Contributes to neuronal excitability by regulating action potential threshold and propagation (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed:36696443, PubMed:36823201). {ECO:0000269|PubMed:24874546, ECO:0000269|PubMed:25239001, ECO:0000269|PubMed:25725044, ECO:0000269|PubMed:26900580, ECO:0000269|PubMed:29726066, ECO:0000269|PubMed:33245860, ECO:0000269|PubMed:36696443, ECO:0000269|PubMed:36823201}.; FUNCTION: [Isoform 5]: More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement. {ECO:0000269|PubMed:19136557}. |
| Q9UQQ2 | SH2B3 | S150 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y385 | UBE2J1 | S266 | ochoa | Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e) | Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress (PubMed:28321712). Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis (PubMed:24020373). Also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26 (PubMed:33472082). Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133 (PubMed:35831855). {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:12082160, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:24020373, ECO:0000269|PubMed:28321712, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:35831855}.; FUNCTION: (Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3 (PubMed:30157886). {ECO:0000269|PubMed:30157886}. |
| Q9Y3M8 | STARD13 | S430 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y4F9 | RIPOR2 | S341 | ochoa | Rho family-interacting cell polarization regulator 2 | Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}. |
| Q9Y6F6 | IRAG1 | S689 | psp | Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1) | Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation (PubMed:14729908). Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q9WUX5, ECO:0000269|PubMed:14729908}. |
| P08174 | CD55 | S106 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
| O60573 | EIF4E2 | S74 | Sugiyama | Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3) | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation (PubMed:17368478, PubMed:22751931, PubMed:25624349, PubMed:33581076, PubMed:9582349). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484). Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism (PubMed:28487484, PubMed:33581076). {ECO:0000250|UniProtKB:Q8BMB3, ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:33581076, ECO:0000269|PubMed:9582349}.; FUNCTION: Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:35878012). In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) with GIGYF2 enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| P48751 | SLC4A3 | S67 | GPS6|SIGNOR|ELM|iPTMNet | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}. |
| Q14164 | IKBKE | S479 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q12809 | KCNH2 | S284 | SIGNOR | Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1) | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Channel properties are modulated by cAMP and subunit assembly (PubMed:10837251). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (PubMed:10219239, PubMed:9230439). {ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:10753933, ECO:0000269|PubMed:10790218, ECO:0000269|PubMed:10837251, ECO:0000269|PubMed:11997281, ECO:0000269|PubMed:12063277, ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:22314138, ECO:0000269|PubMed:22359612, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:9230439, ECO:0000269|PubMed:9351446, ECO:0000269|PubMed:9765245}.; FUNCTION: [Isoform A-USO]: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:9765245}.; FUNCTION: [Isoform B-USO]: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421}. |
| Q96RR4 | CAMKK2 | S26 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q99558 | MAP3K14 | S841 | Sugiyama | Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:25406581}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.000006 | 5.199 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.001201 | 2.921 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.001927 | 2.715 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.001055 | 2.977 |
| R-HSA-1483226 | Synthesis of PI | 0.001135 | 2.945 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.003294 | 2.482 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.014182 | 1.848 |
| R-HSA-5602680 | MyD88 deficiency (TLR5) | 0.041948 | 1.377 |
| R-HSA-112412 | SOS-mediated signalling | 0.009246 | 2.034 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 0.009246 | 2.034 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 0.068935 | 1.162 |
| R-HSA-8865999 | MET activates PTPN11 | 0.068935 | 1.162 |
| R-HSA-74713 | IRS activation | 0.095165 | 1.022 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.108003 | 0.967 |
| R-HSA-629587 | Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | 0.120660 | 0.918 |
| R-HSA-5579026 | Defective CYP11A1 causes AICSR | 0.120660 | 0.918 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.133137 | 0.876 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.133137 | 0.876 |
| R-HSA-8875656 | MET receptor recycling | 0.145439 | 0.837 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.145439 | 0.837 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.145439 | 0.837 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.169523 | 0.771 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.169523 | 0.771 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.181310 | 0.742 |
| R-HSA-4839744 | Signaling by APC mutants | 0.181310 | 0.742 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.181310 | 0.742 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.181310 | 0.742 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.181310 | 0.742 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.192931 | 0.715 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.204387 | 0.690 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.204387 | 0.690 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.204387 | 0.690 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.204387 | 0.690 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.204387 | 0.690 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.204387 | 0.690 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.033885 | 1.470 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.237794 | 0.624 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.237794 | 0.624 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.055629 | 1.255 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.259285 | 0.586 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.131186 | 0.882 |
| R-HSA-180292 | GAB1 signalosome | 0.280173 | 0.553 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.082505 | 1.084 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.082505 | 1.084 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.290397 | 0.537 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.290397 | 0.537 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.051557 | 1.288 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.155600 | 0.808 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.155600 | 0.808 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.090646 | 1.043 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.300475 | 0.522 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.300475 | 0.522 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.310411 | 0.508 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.175699 | 0.755 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.110861 | 0.955 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.320206 | 0.495 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.320206 | 0.495 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.320206 | 0.495 |
| R-HSA-380287 | Centrosome maturation | 0.116929 | 0.932 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.329863 | 0.482 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.339384 | 0.469 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.358022 | 0.446 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.376137 | 0.425 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.376137 | 0.425 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.385003 | 0.415 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.385003 | 0.415 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.086888 | 1.061 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.279966 | 0.553 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.388547 | 0.411 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.388547 | 0.411 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.300475 | 0.522 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.142018 | 0.848 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.142018 | 0.848 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.014492 | 1.839 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.150648 | 0.822 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.142018 | 0.848 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.248381 | 0.605 |
| R-HSA-191859 | snRNP Assembly | 0.248381 | 0.605 |
| R-HSA-198203 | PI3K/AKT activation | 0.169523 | 0.771 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.175699 | 0.755 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.011084 | 1.955 |
| R-HSA-191650 | Regulation of gap junction activity | 0.082144 | 1.085 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.145439 | 0.837 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.057869 | 1.238 |
| R-HSA-74749 | Signal attenuation | 0.015195 | 1.818 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.140844 | 0.851 |
| R-HSA-72172 | mRNA Splicing | 0.103899 | 0.983 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.068609 | 1.164 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.013069 | 1.884 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.095165 | 1.022 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.120660 | 0.918 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.226816 | 0.644 |
| R-HSA-9646399 | Aggrephagy | 0.145728 | 0.836 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.264488 | 0.578 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.280616 | 0.552 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.303818 | 0.517 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.306223 | 0.514 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.095165 | 1.022 |
| R-HSA-8851805 | MET activates RAS signaling | 0.204387 | 0.690 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.259285 | 0.586 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.085182 | 1.070 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.227384 | 0.643 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.367144 | 0.435 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.204387 | 0.690 |
| R-HSA-4641258 | Degradation of DVL | 0.131186 | 0.882 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.150648 | 0.822 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.216933 | 0.664 |
| R-HSA-9843745 | Adipogenesis | 0.061222 | 1.213 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.102030 | 0.991 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.257327 | 0.590 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.068935 | 1.162 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.068935 | 1.162 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.082144 | 1.085 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.133137 | 0.876 |
| R-HSA-2395516 | Electron transport from NADPH to Ferredoxin | 0.133137 | 0.876 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.157566 | 0.803 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.169523 | 0.771 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.181310 | 0.742 |
| R-HSA-428540 | Activation of RAC1 | 0.192931 | 0.715 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.192931 | 0.715 |
| R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors | 0.192931 | 0.715 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.192931 | 0.715 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.192931 | 0.715 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.192931 | 0.715 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.085713 | 1.067 |
| R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors | 0.215682 | 0.666 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.237794 | 0.624 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.237794 | 0.624 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.248616 | 0.604 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.259285 | 0.586 |
| R-HSA-8875878 | MET promotes cell motility | 0.135995 | 0.866 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.077264 | 1.112 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.310411 | 0.508 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.320206 | 0.495 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.329863 | 0.482 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.348769 | 0.457 |
| R-HSA-9839394 | TGFBR3 expression | 0.358022 | 0.446 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.376137 | 0.425 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.197886 | 0.704 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.300983 | 0.521 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.263394 | 0.579 |
| R-HSA-6807070 | PTEN Regulation | 0.385122 | 0.414 |
| R-HSA-68877 | Mitotic Prometaphase | 0.188366 | 0.725 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.090010 | 1.046 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.094370 | 1.025 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.121692 | 0.915 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.280173 | 0.553 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.316680 | 0.499 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.085182 | 1.070 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.113879 | 0.944 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.043365 | 1.363 |
| R-HSA-5617833 | Cilium Assembly | 0.081114 | 1.091 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.121692 | 0.915 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.259285 | 0.586 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.373392 | 0.428 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.204387 | 0.690 |
| R-HSA-112399 | IRS-mediated signalling | 0.067244 | 1.172 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.179979 | 0.745 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.065257 | 1.185 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.117012 | 0.932 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.269804 | 0.569 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.280173 | 0.553 |
| R-HSA-9620244 | Long-term potentiation | 0.358022 | 0.446 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.087896 | 1.056 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.215682 | 0.666 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.216933 | 0.664 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.213189 | 0.671 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.090010 | 1.046 |
| R-HSA-9842663 | Signaling by LTK | 0.022386 | 1.650 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 0.108003 | 0.967 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.133137 | 0.876 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.145439 | 0.837 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.157566 | 0.803 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.204387 | 0.690 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.033885 | 1.470 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.226816 | 0.644 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.269804 | 0.569 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.385003 | 0.415 |
| R-HSA-9707616 | Heme signaling | 0.264172 | 0.578 |
| R-HSA-6806834 | Signaling by MET | 0.132623 | 0.877 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.040042 | 1.397 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.040042 | 1.397 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.300475 | 0.522 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.315456 | 0.501 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.038627 | 1.413 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.295736 | 0.529 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.366140 | 0.436 |
| R-HSA-5619084 | ABC transporter disorders | 0.347811 | 0.459 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.006029 | 2.220 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.027812 | 1.556 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.027812 | 1.556 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.145439 | 0.837 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.145439 | 0.837 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.145439 | 0.837 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.169523 | 0.771 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.065257 | 1.185 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.192931 | 0.715 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.192931 | 0.715 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.192931 | 0.715 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.077316 | 1.112 |
| R-HSA-181431 | Acetylcholine binding and downstream events | 0.215682 | 0.666 |
| R-HSA-8963901 | Chylomicron remodeling | 0.215682 | 0.666 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.026448 | 1.578 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.259285 | 0.586 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.269804 | 0.569 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.300475 | 0.522 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.310411 | 0.508 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.310411 | 0.508 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.145676 | 0.837 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.385003 | 0.415 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.385003 | 0.415 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.094370 | 1.025 |
| R-HSA-177929 | Signaling by EGFR | 0.232623 | 0.633 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.019534 | 1.709 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.042027 | 1.376 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.237794 | 0.624 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.348769 | 0.457 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.053912 | 1.268 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.053912 | 1.268 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.036653 | 1.436 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.145439 | 0.837 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.058447 | 1.233 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.206527 | 0.685 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.113879 | 0.944 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.204387 | 0.690 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.237794 | 0.624 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.237794 | 0.624 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.107796 | 0.967 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.227384 | 0.643 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.376137 | 0.425 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.134374 | 0.872 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.116537 | 0.934 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.117012 | 0.932 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.216202 | 0.665 |
| R-HSA-68886 | M Phase | 0.354076 | 0.451 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.165595 | 0.781 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.145676 | 0.837 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.175699 | 0.755 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.095165 | 1.022 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.027812 | 1.556 |
| R-HSA-425381 | Bicarbonate transporters | 0.181310 | 0.742 |
| R-HSA-429947 | Deadenylation of mRNA | 0.069201 | 1.160 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.204387 | 0.690 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.081481 | 1.089 |
| R-HSA-418457 | cGMP effects | 0.226816 | 0.644 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.237794 | 0.624 |
| R-HSA-9857492 | Protein lipoylation | 0.237794 | 0.624 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.237794 | 0.624 |
| R-HSA-209931 | Serotonin and melatonin biosynthesis | 0.248616 | 0.604 |
| R-HSA-432047 | Passive transport by Aquaporins | 0.259285 | 0.586 |
| R-HSA-8853659 | RET signaling | 0.126418 | 0.898 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.320206 | 0.495 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.348769 | 0.457 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.243123 | 0.614 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.026226 | 1.581 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.090010 | 1.046 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.358088 | 0.446 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.081481 | 1.089 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.347811 | 0.459 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.034583 | 1.461 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.169523 | 0.771 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.359754 | 0.444 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.232623 | 0.633 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.181310 | 0.742 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.081481 | 1.089 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.290397 | 0.537 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.320206 | 0.495 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.329863 | 0.482 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.358022 | 0.446 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.385003 | 0.415 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.163210 | 0.787 |
| R-HSA-983189 | Kinesins | 0.253642 | 0.596 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.298330 | 0.525 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.057609 | 1.240 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.138002 | 0.860 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.181310 | 0.742 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.204387 | 0.690 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.204387 | 0.690 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.204387 | 0.690 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.269804 | 0.569 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.310411 | 0.508 |
| R-HSA-167044 | Signalling to RAS | 0.310411 | 0.508 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.320206 | 0.495 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.206527 | 0.685 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.376137 | 0.425 |
| R-HSA-199991 | Membrane Trafficking | 0.163799 | 0.786 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.253642 | 0.596 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.113879 | 0.944 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.134374 | 0.872 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.367144 | 0.435 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.147868 | 0.830 |
| R-HSA-4086398 | Ca2+ pathway | 0.321896 | 0.492 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.098360 | 1.007 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.269804 | 0.569 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.329863 | 0.482 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.358022 | 0.446 |
| R-HSA-9909396 | Circadian clock | 0.354259 | 0.451 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.201344 | 0.696 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.311456 | 0.507 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.311456 | 0.507 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.356387 | 0.448 |
| R-HSA-4839726 | Chromatin organization | 0.340090 | 0.468 |
| R-HSA-69275 | G2/M Transition | 0.336541 | 0.473 |
| R-HSA-5578768 | Physiological factors | 0.226816 | 0.644 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.107796 | 0.967 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.248616 | 0.604 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.259285 | 0.586 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.280173 | 0.553 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.320206 | 0.495 |
| R-HSA-109704 | PI3K Cascade | 0.201344 | 0.696 |
| R-HSA-202424 | Downstream TCR signaling | 0.169460 | 0.771 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.342978 | 0.465 |
| R-HSA-1280218 | Adaptive Immune System | 0.086068 | 1.065 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.081481 | 1.089 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.098789 | 1.005 |
| R-HSA-5576891 | Cardiac conduction | 0.061222 | 1.213 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.215682 | 0.666 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.339384 | 0.469 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.149003 | 0.827 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.103265 | 0.986 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.108003 | 0.967 |
| R-HSA-210990 | PECAM1 interactions | 0.181310 | 0.742 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.013956 | 1.855 |
| R-HSA-210993 | Tie2 Signaling | 0.280173 | 0.553 |
| R-HSA-3295583 | TRP channels | 0.367144 | 0.435 |
| R-HSA-162582 | Signal Transduction | 0.035426 | 1.451 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.061451 | 1.211 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.339384 | 0.469 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.337480 | 0.472 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.248616 | 0.604 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.264172 | 0.578 |
| R-HSA-9830369 | Kidney development | 0.290484 | 0.537 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.033708 | 1.472 |
| R-HSA-373752 | Netrin-1 signaling | 0.170635 | 0.768 |
| R-HSA-3214842 | HDMs demethylate histones | 0.358022 | 0.446 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.373580 | 0.428 |
| R-HSA-8963896 | HDL assembly | 0.226816 | 0.644 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.226816 | 0.644 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.367144 | 0.435 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.242397 | 0.615 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.274703 | 0.561 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.383513 | 0.416 |
| R-HSA-425410 | Metal ion SLC transporters | 0.191028 | 0.719 |
| R-HSA-2586552 | Signaling by Leptin | 0.169523 | 0.771 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.191028 | 0.719 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.165595 | 0.781 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.145439 | 0.837 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.157566 | 0.803 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.055629 | 1.255 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.121692 | 0.915 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.021687 | 1.664 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.248381 | 0.605 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.294919 | 0.530 |
| R-HSA-2559583 | Cellular Senescence | 0.317271 | 0.499 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.242397 | 0.615 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.368742 | 0.433 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.292201 | 0.534 |
| R-HSA-397014 | Muscle contraction | 0.238987 | 0.622 |
| R-HSA-9607240 | FLT3 Signaling | 0.150648 | 0.822 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.280173 | 0.553 |
| R-HSA-5688426 | Deubiquitination | 0.356942 | 0.447 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.294919 | 0.530 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.294919 | 0.530 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.348769 | 0.457 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.381610 | 0.418 |
| R-HSA-9824446 | Viral Infection Pathways | 0.375914 | 0.425 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.017691 | 1.752 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.232623 | 0.633 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.329863 | 0.482 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.358022 | 0.446 |
| R-HSA-202403 | TCR signaling | 0.253782 | 0.596 |
| R-HSA-73887 | Death Receptor Signaling | 0.012524 | 1.902 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.169523 | 0.771 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.061392 | 1.212 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.014688 | 1.833 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.094370 | 1.025 |
| R-HSA-525793 | Myogenesis | 0.367144 | 0.435 |
| R-HSA-75893 | TNF signaling | 0.232623 | 0.633 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.035851 | 1.445 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.126418 | 0.898 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.238621 | 0.622 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.296070 | 0.529 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.204387 | 0.690 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.029776 | 1.526 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.261415 | 0.583 |
| R-HSA-1483255 | PI Metabolism | 0.219907 | 0.658 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.339384 | 0.469 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.091179 | 1.040 |
| R-HSA-75153 | Apoptotic execution phase | 0.043099 | 1.366 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.160583 | 0.794 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.348769 | 0.457 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.250969 | 0.600 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.145728 | 0.836 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.295736 | 0.529 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.385003 | 0.415 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.358022 | 0.446 |
| R-HSA-5357801 | Programmed Cell Death | 0.105527 | 0.977 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.339384 | 0.469 |
| R-HSA-109581 | Apoptosis | 0.117379 | 0.930 |
| R-HSA-2028269 | Signaling by Hippo | 0.269804 | 0.569 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.363205 | 0.440 |
| R-HSA-1483257 | Phospholipid metabolism | 0.296071 | 0.529 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.393563 | 0.405 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.393743 | 0.405 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.393743 | 0.405 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.393743 | 0.405 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.393743 | 0.405 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.398561 | 0.400 |
| R-HSA-2424491 | DAP12 signaling | 0.402359 | 0.395 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.402359 | 0.395 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.402359 | 0.395 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.402359 | 0.395 |
| R-HSA-9663891 | Selective autophagy | 0.403539 | 0.394 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.405302 | 0.392 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.408498 | 0.389 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.410854 | 0.386 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.410854 | 0.386 |
| R-HSA-186763 | Downstream signal transduction | 0.410854 | 0.386 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.418356 | 0.378 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.419228 | 0.378 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.419228 | 0.378 |
| R-HSA-422475 | Axon guidance | 0.419403 | 0.377 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.419422 | 0.377 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.423197 | 0.373 |
| R-HSA-166520 | Signaling by NTRKs | 0.423197 | 0.373 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.423253 | 0.373 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.426883 | 0.370 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.427484 | 0.369 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.427484 | 0.369 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.427484 | 0.369 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.427484 | 0.369 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.427484 | 0.369 |
| R-HSA-354192 | Integrin signaling | 0.427484 | 0.369 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.428130 | 0.368 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.432985 | 0.364 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.435623 | 0.361 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.435623 | 0.361 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.435623 | 0.361 |
| R-HSA-68882 | Mitotic Anaphase | 0.435848 | 0.361 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.437818 | 0.359 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.439003 | 0.358 |
| R-HSA-9679506 | SARS-CoV Infections | 0.439676 | 0.357 |
| R-HSA-418990 | Adherens junctions interactions | 0.442153 | 0.354 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.442628 | 0.354 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.443647 | 0.353 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.443647 | 0.353 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.447416 | 0.349 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.451557 | 0.345 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.451557 | 0.345 |
| R-HSA-169911 | Regulation of Apoptosis | 0.451557 | 0.345 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.451557 | 0.345 |
| R-HSA-187687 | Signalling to ERKs | 0.451557 | 0.345 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.452181 | 0.345 |
| R-HSA-1296071 | Potassium Channels | 0.452181 | 0.345 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.456922 | 0.340 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.459355 | 0.338 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.459355 | 0.338 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.459355 | 0.338 |
| R-HSA-163560 | Triglyceride catabolism | 0.459355 | 0.338 |
| R-HSA-111933 | Calmodulin induced events | 0.459355 | 0.338 |
| R-HSA-111997 | CaM pathway | 0.459355 | 0.338 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.459355 | 0.338 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.459355 | 0.338 |
| R-HSA-9711097 | Cellular response to starvation | 0.460448 | 0.337 |
| R-HSA-190236 | Signaling by FGFR | 0.461640 | 0.336 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.461640 | 0.336 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.461640 | 0.336 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.461640 | 0.336 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.467043 | 0.331 |
| R-HSA-4641257 | Degradation of AXIN | 0.467043 | 0.331 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.467043 | 0.331 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 0.467043 | 0.331 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.467043 | 0.331 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.467043 | 0.331 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.467778 | 0.330 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.471004 | 0.327 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.471004 | 0.327 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.473347 | 0.325 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 0.474622 | 0.324 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.474622 | 0.324 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.474622 | 0.324 |
| R-HSA-195721 | Signaling by WNT | 0.476871 | 0.322 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.480269 | 0.319 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.482094 | 0.317 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.482094 | 0.317 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.482094 | 0.317 |
| R-HSA-69541 | Stabilization of p53 | 0.482094 | 0.317 |
| R-HSA-201556 | Signaling by ALK | 0.482094 | 0.317 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.482094 | 0.317 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.488369 | 0.311 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.489436 | 0.310 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.489459 | 0.310 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.489459 | 0.310 |
| R-HSA-167169 | HIV Transcription Elongation | 0.489459 | 0.310 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.489459 | 0.310 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.489459 | 0.310 |
| R-HSA-5260271 | Diseases of Immune System | 0.489459 | 0.310 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.489459 | 0.310 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.489459 | 0.310 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.489459 | 0.310 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.489459 | 0.310 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.489459 | 0.310 |
| R-HSA-9675108 | Nervous system development | 0.493930 | 0.306 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.493981 | 0.306 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.493981 | 0.306 |
| R-HSA-9833110 | RSV-host interactions | 0.493981 | 0.306 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.496721 | 0.304 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.496721 | 0.304 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.496721 | 0.304 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.496721 | 0.304 |
| R-HSA-9694548 | Maturation of spike protein | 0.496721 | 0.304 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.496721 | 0.304 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.498500 | 0.302 |
| R-HSA-418346 | Platelet homeostasis | 0.502994 | 0.298 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.503880 | 0.298 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.503880 | 0.298 |
| R-HSA-157118 | Signaling by NOTCH | 0.509890 | 0.293 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.510937 | 0.292 |
| R-HSA-111996 | Ca-dependent events | 0.510937 | 0.292 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.511904 | 0.291 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.511904 | 0.291 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.514281 | 0.289 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.516319 | 0.287 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.516319 | 0.287 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.517894 | 0.286 |
| R-HSA-8854214 | TBC/RABGAPs | 0.517894 | 0.286 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.520709 | 0.283 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.520709 | 0.283 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.524707 | 0.280 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.524753 | 0.280 |
| R-HSA-2172127 | DAP12 interactions | 0.524753 | 0.280 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.524753 | 0.280 |
| R-HSA-9907900 | Proteasome assembly | 0.524753 | 0.280 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.531515 | 0.274 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.531515 | 0.274 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.531515 | 0.274 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.531515 | 0.274 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.531515 | 0.274 |
| R-HSA-9824272 | Somitogenesis | 0.531515 | 0.274 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.531515 | 0.274 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.533716 | 0.273 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.537998 | 0.269 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.538180 | 0.269 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.538180 | 0.269 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.538180 | 0.269 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.538180 | 0.269 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.538180 | 0.269 |
| R-HSA-421270 | Cell-cell junction organization | 0.542361 | 0.266 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.544752 | 0.264 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.544752 | 0.264 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 0.544752 | 0.264 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.546481 | 0.262 |
| R-HSA-112316 | Neuronal System | 0.550235 | 0.259 |
| R-HSA-5620924 | Intraflagellar transport | 0.551230 | 0.259 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.551230 | 0.259 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.551898 | 0.258 |
| R-HSA-373760 | L1CAM interactions | 0.554855 | 0.256 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.557617 | 0.254 |
| R-HSA-9766229 | Degradation of CDH1 | 0.557617 | 0.254 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.557617 | 0.254 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 0.557617 | 0.254 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.557617 | 0.254 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.557617 | 0.254 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.559001 | 0.253 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.559001 | 0.253 |
| R-HSA-74160 | Gene expression (Transcription) | 0.563721 | 0.249 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.563913 | 0.249 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.567211 | 0.246 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.567211 | 0.246 |
| R-HSA-8953854 | Metabolism of RNA | 0.567794 | 0.246 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.570119 | 0.244 |
| R-HSA-2514856 | The phototransduction cascade | 0.570119 | 0.244 |
| R-HSA-68875 | Mitotic Prophase | 0.571274 | 0.243 |
| R-HSA-212436 | Generic Transcription Pathway | 0.573772 | 0.241 |
| R-HSA-72187 | mRNA 3'-end processing | 0.576238 | 0.239 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.576238 | 0.239 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.576238 | 0.239 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.576238 | 0.239 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.576238 | 0.239 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.576238 | 0.239 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.578155 | 0.238 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.579319 | 0.237 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.579319 | 0.237 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.582270 | 0.235 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.582270 | 0.235 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.582270 | 0.235 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.583299 | 0.234 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.587252 | 0.231 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.588217 | 0.230 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.588217 | 0.230 |
| R-HSA-9609690 | HCMV Early Events | 0.594070 | 0.226 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.594079 | 0.226 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.599858 | 0.222 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.599858 | 0.222 |
| R-HSA-5578775 | Ion homeostasis | 0.599858 | 0.222 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 0.599858 | 0.222 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.599858 | 0.222 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.602661 | 0.220 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.605556 | 0.218 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.606521 | 0.217 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.606601 | 0.217 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.608051 | 0.216 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.612651 | 0.213 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.615692 | 0.211 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.615692 | 0.211 |
| R-HSA-9033241 | Peroxisomal protein import | 0.616709 | 0.210 |
| R-HSA-8979227 | Triglyceride metabolism | 0.616709 | 0.210 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.616709 | 0.210 |
| R-HSA-446728 | Cell junction organization | 0.617085 | 0.210 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.622167 | 0.206 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.622167 | 0.206 |
| R-HSA-351202 | Metabolism of polyamines | 0.622167 | 0.206 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.622167 | 0.206 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.622167 | 0.206 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.622167 | 0.206 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.622167 | 0.206 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.622167 | 0.206 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.622167 | 0.206 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.627548 | 0.202 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.627548 | 0.202 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.627548 | 0.202 |
| R-HSA-112043 | PLC beta mediated events | 0.627548 | 0.202 |
| R-HSA-450294 | MAP kinase activation | 0.627548 | 0.202 |
| R-HSA-211976 | Endogenous sterols | 0.627548 | 0.202 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.627548 | 0.202 |
| R-HSA-6805567 | Keratinization | 0.627696 | 0.202 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.632853 | 0.199 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.632853 | 0.199 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.632853 | 0.199 |
| R-HSA-186797 | Signaling by PDGF | 0.632853 | 0.199 |
| R-HSA-8848021 | Signaling by PTK6 | 0.638082 | 0.195 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.638082 | 0.195 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.638082 | 0.195 |
| R-HSA-373755 | Semaphorin interactions | 0.638082 | 0.195 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.645215 | 0.190 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.645272 | 0.190 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.646735 | 0.189 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.648320 | 0.188 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.650219 | 0.187 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.653330 | 0.185 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.653675 | 0.185 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.658269 | 0.182 |
| R-HSA-112040 | G-protein mediated events | 0.658269 | 0.182 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.658269 | 0.182 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.658269 | 0.182 |
| R-HSA-1632852 | Macroautophagy | 0.660507 | 0.180 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.662487 | 0.179 |
| R-HSA-167172 | Transcription of the HIV genome | 0.663138 | 0.178 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.663138 | 0.178 |
| R-HSA-5218859 | Regulated Necrosis | 0.663138 | 0.178 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.667231 | 0.176 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.670552 | 0.174 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.672670 | 0.172 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.672670 | 0.172 |
| R-HSA-448424 | Interleukin-17 signaling | 0.672670 | 0.172 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.672670 | 0.172 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.672670 | 0.172 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.673847 | 0.171 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.677334 | 0.169 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.677334 | 0.169 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.677334 | 0.169 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.681933 | 0.166 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.681933 | 0.166 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.681933 | 0.166 |
| R-HSA-2187338 | Visual phototransduction | 0.683572 | 0.165 |
| R-HSA-162906 | HIV Infection | 0.686442 | 0.163 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.686466 | 0.163 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.686466 | 0.163 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.686466 | 0.163 |
| R-HSA-69242 | S Phase | 0.686761 | 0.163 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.687342 | 0.163 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.690935 | 0.161 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.693059 | 0.159 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.695340 | 0.158 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.699172 | 0.155 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.699253 | 0.155 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.699253 | 0.155 |
| R-HSA-5689603 | UCH proteinases | 0.699683 | 0.155 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.699683 | 0.155 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.703964 | 0.152 |
| R-HSA-449147 | Signaling by Interleukins | 0.707067 | 0.151 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.708185 | 0.150 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.708185 | 0.150 |
| R-HSA-4086400 | PCP/CE pathway | 0.708185 | 0.150 |
| R-HSA-1989781 | PPARA activates gene expression | 0.708350 | 0.150 |
| R-HSA-1500931 | Cell-Cell communication | 0.708512 | 0.150 |
| R-HSA-9612973 | Autophagy | 0.711332 | 0.148 |
| R-HSA-9659379 | Sensory processing of sound | 0.712345 | 0.147 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.712345 | 0.147 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.714287 | 0.146 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.716447 | 0.145 |
| R-HSA-109582 | Hemostasis | 0.717302 | 0.144 |
| R-HSA-877300 | Interferon gamma signaling | 0.720123 | 0.143 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.720490 | 0.142 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.723507 | 0.141 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.724476 | 0.140 |
| R-HSA-2262752 | Cellular responses to stress | 0.727052 | 0.138 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.728405 | 0.138 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.732279 | 0.135 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.736097 | 0.133 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.739861 | 0.131 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.739861 | 0.131 |
| R-HSA-9609646 | HCMV Infection | 0.742561 | 0.129 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.743572 | 0.129 |
| R-HSA-156902 | Peptide chain elongation | 0.750836 | 0.124 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.757896 | 0.120 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.760118 | 0.119 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.761350 | 0.118 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.761350 | 0.118 |
| R-HSA-1266738 | Developmental Biology | 0.762540 | 0.118 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.764756 | 0.116 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.768113 | 0.115 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.768113 | 0.115 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.771422 | 0.113 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.777901 | 0.109 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.781071 | 0.107 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.781071 | 0.107 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.784196 | 0.106 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.787277 | 0.104 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.791222 | 0.102 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.793308 | 0.101 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.798331 | 0.098 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.799169 | 0.097 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.802037 | 0.096 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.802037 | 0.096 |
| R-HSA-192823 | Viral mRNA Translation | 0.804864 | 0.094 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.807651 | 0.093 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.807651 | 0.093 |
| R-HSA-111885 | Opioid Signalling | 0.807651 | 0.093 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.810398 | 0.091 |
| R-HSA-6798695 | Neutrophil degranulation | 0.814828 | 0.089 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.818408 | 0.087 |
| R-HSA-69239 | Synthesis of DNA | 0.818408 | 0.087 |
| R-HSA-211000 | Gene Silencing by RNA | 0.818408 | 0.087 |
| R-HSA-1640170 | Cell Cycle | 0.820880 | 0.086 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.821003 | 0.086 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.821003 | 0.086 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.821003 | 0.086 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.823560 | 0.084 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.826081 | 0.083 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.831016 | 0.080 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.831016 | 0.080 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.831016 | 0.080 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.833431 | 0.079 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.840472 | 0.075 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.842752 | 0.074 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.845000 | 0.073 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.845000 | 0.073 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.855769 | 0.068 |
| R-HSA-8951664 | Neddylation | 0.859897 | 0.066 |
| R-HSA-977606 | Regulation of Complement cascade | 0.863845 | 0.064 |
| R-HSA-69206 | G1/S Transition | 0.865793 | 0.063 |
| R-HSA-194138 | Signaling by VEGF | 0.865793 | 0.063 |
| R-HSA-69481 | G2/M Checkpoints | 0.869605 | 0.061 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.883092 | 0.054 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.888725 | 0.051 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.895737 | 0.048 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.899412 | 0.046 |
| R-HSA-5663205 | Infectious disease | 0.902261 | 0.045 |
| R-HSA-168256 | Immune System | 0.903503 | 0.044 |
| R-HSA-166658 | Complement cascade | 0.903672 | 0.044 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.905052 | 0.043 |
| R-HSA-9758941 | Gastrulation | 0.909075 | 0.041 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.910378 | 0.041 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.911663 | 0.040 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.913359 | 0.039 |
| R-HSA-9609507 | Protein localization | 0.914177 | 0.039 |
| R-HSA-69306 | DNA Replication | 0.914177 | 0.039 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.914177 | 0.039 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.915407 | 0.038 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.916619 | 0.038 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.918269 | 0.037 |
| R-HSA-9610379 | HCMV Late Events | 0.918993 | 0.037 |
| R-HSA-162587 | HIV Life Cycle | 0.918993 | 0.037 |
| R-HSA-168249 | Innate Immune System | 0.921055 | 0.036 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.926782 | 0.033 |
| R-HSA-913531 | Interferon Signaling | 0.929424 | 0.032 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.929888 | 0.032 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.933826 | 0.030 |
| R-HSA-418555 | G alpha (s) signalling events | 0.934775 | 0.029 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.936634 | 0.028 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.936634 | 0.028 |
| R-HSA-372790 | Signaling by GPCR | 0.936844 | 0.028 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.939040 | 0.027 |
| R-HSA-388396 | GPCR downstream signalling | 0.939467 | 0.027 |
| R-HSA-168255 | Influenza Infection | 0.941899 | 0.026 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.947494 | 0.023 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.948991 | 0.023 |
| R-HSA-983712 | Ion channel transport | 0.949724 | 0.022 |
| R-HSA-382551 | Transport of small molecules | 0.952034 | 0.021 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.953268 | 0.021 |
| R-HSA-428157 | Sphingolipid metabolism | 0.957741 | 0.019 |
| R-HSA-8957322 | Metabolism of steroids | 0.958056 | 0.019 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.964995 | 0.015 |
| R-HSA-72312 | rRNA processing | 0.973425 | 0.012 |
| R-HSA-15869 | Metabolism of nucleotides | 0.974924 | 0.011 |
| R-HSA-8939211 | ESR-mediated signaling | 0.975285 | 0.011 |
| R-HSA-1643685 | Disease | 0.977555 | 0.010 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.982248 | 0.008 |
| R-HSA-416476 | G alpha (q) signalling events | 0.983304 | 0.007 |
| R-HSA-418594 | G alpha (i) signalling events | 0.985164 | 0.006 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.985564 | 0.006 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.986380 | 0.006 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.986962 | 0.006 |
| R-HSA-9658195 | Leishmania infection | 0.986962 | 0.006 |
| R-HSA-72766 | Translation | 0.988770 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 0.992701 | 0.003 |
| R-HSA-73894 | DNA Repair | 0.995883 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.996117 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 0.996236 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.997534 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997962 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.998481 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998604 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999631 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999993 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999998 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MSK1 |
0.856 | 0.823 | -3 | 0.768 |
PRKX |
0.853 | 0.737 | -3 | 0.795 |
RSK2 |
0.852 | 0.791 | -3 | 0.776 |
PKACB |
0.851 | 0.746 | -2 | 0.874 |
PKACA |
0.851 | 0.761 | -2 | 0.863 |
RSK4 |
0.848 | 0.764 | -3 | 0.806 |
MSK2 |
0.844 | 0.819 | -3 | 0.779 |
CLK2 |
0.843 | 0.692 | -3 | 0.797 |
P90RSK |
0.841 | 0.770 | -3 | 0.777 |
AKT2 |
0.841 | 0.806 | -3 | 0.838 |
RSK3 |
0.840 | 0.764 | -3 | 0.772 |
SGK1 |
0.837 | 0.801 | -3 | 0.890 |
AKT3 |
0.837 | 0.789 | -3 | 0.883 |
CLK4 |
0.836 | 0.737 | -3 | 0.760 |
AURC |
0.833 | 0.578 | -2 | 0.898 |
MYLK4 |
0.831 | 0.751 | -2 | 0.888 |
PRKD2 |
0.831 | 0.633 | -3 | 0.726 |
PKACG |
0.831 | 0.649 | -2 | 0.836 |
MAPKAPK2 |
0.829 | 0.625 | -3 | 0.777 |
CLK1 |
0.829 | 0.674 | -3 | 0.766 |
AKT1 |
0.829 | 0.765 | -3 | 0.806 |
SBK |
0.826 | 0.755 | -3 | 0.903 |
AURB |
0.826 | 0.591 | -2 | 0.897 |
PIM1 |
0.825 | 0.678 | -3 | 0.738 |
P70S6KB |
0.825 | 0.703 | -3 | 0.708 |
SRPK2 |
0.825 | 0.634 | -3 | 0.862 |
AURA |
0.825 | 0.594 | -2 | 0.906 |
SRPK1 |
0.825 | 0.603 | -3 | 0.800 |
PKG2 |
0.824 | 0.619 | -2 | 0.849 |
SGK3 |
0.823 | 0.698 | -3 | 0.717 |
PIM3 |
0.823 | 0.629 | -3 | 0.661 |
PRKD3 |
0.821 | 0.674 | -3 | 0.762 |
PAK6 |
0.820 | 0.516 | -2 | 0.886 |
MAPKAPK3 |
0.820 | 0.620 | -3 | 0.697 |
CAMK1D |
0.819 | 0.724 | -3 | 0.801 |
DYRK3 |
0.818 | 0.626 | 1 | 0.736 |
PAK1 |
0.817 | 0.584 | -2 | 0.888 |
SKMLCK |
0.816 | 0.631 | -2 | 0.843 |
P70S6K |
0.816 | 0.684 | -3 | 0.792 |
PIM2 |
0.816 | 0.686 | -3 | 0.781 |
PAK4 |
0.815 | 0.563 | -2 | 0.886 |
CDKL1 |
0.815 | 0.685 | -3 | 0.720 |
PRKD1 |
0.815 | 0.494 | -3 | 0.636 |
NDR1 |
0.815 | 0.557 | -3 | 0.624 |
CDKL5 |
0.814 | 0.580 | -3 | 0.742 |
NDR2 |
0.814 | 0.435 | -3 | 0.594 |
CAMK1A |
0.813 | 0.725 | -3 | 0.827 |
CAMK1B |
0.812 | 0.724 | -3 | 0.591 |
DAPK1 |
0.812 | 0.762 | -3 | 0.723 |
PKG1 |
0.811 | 0.655 | -2 | 0.816 |
PAK5 |
0.811 | 0.562 | -2 | 0.862 |
CHK2 |
0.811 | 0.740 | -3 | 0.849 |
CAMK2A |
0.810 | 0.495 | 2 | 0.760 |
SRPK3 |
0.810 | 0.563 | -3 | 0.794 |
CAMLCK |
0.809 | 0.727 | -2 | 0.836 |
PAK3 |
0.809 | 0.553 | -2 | 0.869 |
CLK3 |
0.809 | 0.405 | 1 | 0.810 |
ICK |
0.808 | 0.589 | -3 | 0.667 |
CAMK1G |
0.807 | 0.646 | -3 | 0.740 |
MRCKB |
0.807 | 0.720 | -3 | 0.747 |
HIPK4 |
0.805 | 0.426 | 1 | 0.787 |
PKN3 |
0.805 | 0.528 | -3 | 0.632 |
DAPK3 |
0.805 | 0.742 | -3 | 0.699 |
PAK2 |
0.805 | 0.567 | -2 | 0.879 |
DYRK1A |
0.804 | 0.522 | 1 | 0.738 |
CAMK4 |
0.804 | 0.572 | -3 | 0.599 |
MAPKAPK5 |
0.804 | 0.623 | -3 | 0.752 |
DYRK2 |
0.804 | 0.378 | 1 | 0.719 |
DAPK2 |
0.803 | 0.745 | -3 | 0.560 |
MRCKA |
0.803 | 0.695 | -3 | 0.726 |
CAMK2B |
0.803 | 0.402 | 2 | 0.753 |
MNK2 |
0.803 | 0.465 | -2 | 0.857 |
SMMLCK |
0.802 | 0.736 | -3 | 0.657 |
DYRK4 |
0.802 | 0.361 | 1 | 0.639 |
CAMK2D |
0.802 | 0.418 | -3 | 0.565 |
CRIK |
0.800 | 0.706 | -3 | 0.825 |
SIK |
0.800 | 0.513 | -3 | 0.699 |
LATS2 |
0.799 | 0.340 | -5 | 0.745 |
DMPK1 |
0.799 | 0.734 | -3 | 0.731 |
BRSK1 |
0.799 | 0.476 | -3 | 0.685 |
MAK |
0.799 | 0.501 | -2 | 0.701 |
HIPK1 |
0.799 | 0.453 | 1 | 0.730 |
NUAK2 |
0.798 | 0.495 | -3 | 0.638 |
PKN2 |
0.798 | 0.482 | -3 | 0.572 |
AMPKA2 |
0.798 | 0.491 | -3 | 0.638 |
HIPK2 |
0.797 | 0.370 | 1 | 0.625 |
MNK1 |
0.796 | 0.445 | -2 | 0.845 |
MELK |
0.796 | 0.514 | -3 | 0.652 |
AMPKA1 |
0.793 | 0.439 | -3 | 0.579 |
QSK |
0.793 | 0.393 | 4 | 0.777 |
PKN1 |
0.792 | 0.593 | -3 | 0.767 |
DYRK1B |
0.792 | 0.374 | 1 | 0.664 |
DCAMKL1 |
0.791 | 0.556 | -3 | 0.688 |
HIPK3 |
0.791 | 0.446 | 1 | 0.742 |
ROCK2 |
0.790 | 0.658 | -3 | 0.688 |
PKCD |
0.790 | 0.412 | 2 | 0.661 |
COT |
0.789 | 0.070 | 2 | 0.794 |
WNK1 |
0.789 | 0.321 | -2 | 0.760 |
ROCK1 |
0.788 | 0.684 | -3 | 0.724 |
TSSK1 |
0.788 | 0.367 | -3 | 0.565 |
NUAK1 |
0.788 | 0.446 | -3 | 0.693 |
LATS1 |
0.787 | 0.403 | -3 | 0.569 |
CDC7 |
0.785 | 0.116 | 1 | 0.847 |
MARK4 |
0.783 | 0.209 | 4 | 0.812 |
NIK |
0.783 | 0.496 | -3 | 0.486 |
BRSK2 |
0.783 | 0.343 | -3 | 0.606 |
MOK |
0.782 | 0.509 | 1 | 0.747 |
TSSK2 |
0.781 | 0.310 | -5 | 0.850 |
QIK |
0.781 | 0.338 | -3 | 0.546 |
RAF1 |
0.780 | 0.194 | 1 | 0.871 |
PASK |
0.780 | 0.497 | -3 | 0.595 |
NIM1 |
0.779 | 0.267 | 3 | 0.728 |
IKKB |
0.779 | 0.055 | -2 | 0.553 |
MOS |
0.779 | 0.097 | 1 | 0.860 |
DCAMKL2 |
0.779 | 0.431 | -3 | 0.660 |
NLK |
0.778 | 0.146 | 1 | 0.845 |
PKCB |
0.777 | 0.322 | 2 | 0.616 |
CHK1 |
0.777 | 0.325 | -3 | 0.562 |
RIPK3 |
0.777 | 0.151 | 3 | 0.701 |
PKCG |
0.777 | 0.322 | 2 | 0.618 |
MARK3 |
0.777 | 0.249 | 4 | 0.747 |
PKCE |
0.777 | 0.466 | 2 | 0.598 |
CAMK2G |
0.777 | 0.056 | 2 | 0.751 |
PKCH |
0.775 | 0.365 | 2 | 0.605 |
RIPK1 |
0.775 | 0.247 | 1 | 0.828 |
GRK1 |
0.775 | 0.056 | -2 | 0.621 |
PKCT |
0.775 | 0.439 | 2 | 0.609 |
MARK1 |
0.775 | 0.277 | 4 | 0.760 |
PHKG1 |
0.775 | 0.350 | -3 | 0.615 |
PKCA |
0.775 | 0.299 | 2 | 0.602 |
MTOR |
0.774 | 0.034 | 1 | 0.808 |
MST4 |
0.774 | 0.170 | 2 | 0.708 |
SNRK |
0.774 | 0.338 | 2 | 0.614 |
ATR |
0.772 | 0.103 | 1 | 0.812 |
GRK6 |
0.772 | 0.107 | 1 | 0.871 |
MARK2 |
0.772 | 0.222 | 4 | 0.723 |
HUNK |
0.772 | 0.084 | 2 | 0.763 |
PDHK4 |
0.771 | -0.063 | 1 | 0.868 |
PRPK |
0.770 | -0.075 | -1 | 0.839 |
WNK3 |
0.770 | 0.148 | 1 | 0.828 |
DRAK1 |
0.769 | 0.268 | 1 | 0.812 |
PKCZ |
0.768 | 0.282 | 2 | 0.659 |
TBK1 |
0.768 | -0.051 | 1 | 0.786 |
PKCI |
0.768 | 0.375 | 2 | 0.614 |
PHKG2 |
0.768 | 0.381 | -3 | 0.626 |
ERK5 |
0.767 | 0.017 | 1 | 0.831 |
MASTL |
0.767 | 0.049 | -2 | 0.616 |
IKKE |
0.766 | -0.048 | 1 | 0.781 |
GRK5 |
0.764 | -0.037 | -3 | 0.311 |
TGFBR2 |
0.763 | 0.022 | -2 | 0.564 |
CDK10 |
0.762 | 0.212 | 1 | 0.642 |
DLK |
0.762 | 0.148 | 1 | 0.864 |
PDHK1 |
0.762 | -0.105 | 1 | 0.860 |
BCKDK |
0.761 | -0.044 | -1 | 0.803 |
DSTYK |
0.761 | -0.121 | 2 | 0.806 |
GCN2 |
0.761 | -0.137 | 2 | 0.718 |
SSTK |
0.761 | 0.234 | 4 | 0.751 |
BMPR2 |
0.760 | -0.173 | -2 | 0.637 |
IKKA |
0.759 | -0.080 | -2 | 0.516 |
CDK7 |
0.758 | 0.060 | 1 | 0.679 |
ATM |
0.758 | 0.036 | 1 | 0.748 |
ULK2 |
0.758 | -0.161 | 2 | 0.681 |
DNAPK |
0.757 | 0.060 | 1 | 0.702 |
CDK14 |
0.757 | 0.167 | 1 | 0.658 |
WNK4 |
0.756 | 0.226 | -2 | 0.727 |
JNK2 |
0.755 | 0.052 | 1 | 0.641 |
GRK4 |
0.754 | -0.089 | -2 | 0.605 |
FAM20C |
0.753 | 0.008 | 2 | 0.584 |
TGFBR1 |
0.753 | -0.031 | -2 | 0.544 |
BMPR1B |
0.753 | 0.016 | 1 | 0.843 |
CHAK2 |
0.752 | -0.068 | -1 | 0.835 |
PLK1 |
0.752 | -0.024 | -2 | 0.550 |
ANKRD3 |
0.752 | 0.002 | 1 | 0.877 |
ALK4 |
0.751 | -0.034 | -2 | 0.579 |
MEK1 |
0.751 | 0.027 | 2 | 0.756 |
MLK1 |
0.750 | -0.112 | 2 | 0.700 |
GSK3B |
0.750 | 0.111 | 4 | 0.571 |
GRK7 |
0.750 | 0.038 | 1 | 0.792 |
KIS |
0.750 | -0.029 | 1 | 0.699 |
CK1A2 |
0.749 | -0.026 | -3 | 0.153 |
NEK7 |
0.749 | -0.184 | -3 | 0.292 |
CK1E |
0.749 | -0.061 | -3 | 0.164 |
NEK2 |
0.749 | -0.021 | 2 | 0.687 |
ULK1 |
0.749 | -0.177 | -3 | 0.269 |
PKR |
0.748 | 0.054 | 1 | 0.836 |
NEK9 |
0.748 | -0.151 | 2 | 0.719 |
TTBK2 |
0.748 | -0.094 | 2 | 0.622 |
CDK8 |
0.747 | -0.037 | 1 | 0.677 |
GRK2 |
0.747 | -0.001 | -2 | 0.529 |
JNK3 |
0.747 | 0.020 | 1 | 0.664 |
MLK2 |
0.747 | -0.128 | 2 | 0.709 |
PDK1 |
0.747 | 0.320 | 1 | 0.810 |
P38A |
0.746 | 0.024 | 1 | 0.722 |
CDK9 |
0.746 | 0.040 | 1 | 0.663 |
CDK19 |
0.745 | -0.025 | 1 | 0.641 |
ALK2 |
0.745 | -0.027 | -2 | 0.559 |
VRK2 |
0.745 | -0.048 | 1 | 0.878 |
CDK12 |
0.744 | 0.049 | 1 | 0.630 |
PLK3 |
0.744 | -0.059 | 2 | 0.742 |
IRE1 |
0.743 | 0.000 | 1 | 0.782 |
SMG1 |
0.743 | -0.040 | 1 | 0.753 |
NEK6 |
0.743 | -0.179 | -2 | 0.600 |
GSK3A |
0.743 | 0.092 | 4 | 0.580 |
MST3 |
0.743 | 0.098 | 2 | 0.721 |
CDK13 |
0.743 | 0.006 | 1 | 0.653 |
CDK18 |
0.742 | 0.024 | 1 | 0.608 |
YSK4 |
0.742 | -0.075 | 1 | 0.805 |
BRAF |
0.741 | 0.025 | -4 | 0.794 |
CK1D |
0.741 | -0.066 | -3 | 0.133 |
ACVR2B |
0.741 | -0.054 | -2 | 0.537 |
P38B |
0.740 | 0.010 | 1 | 0.656 |
GRK3 |
0.739 | -0.010 | -2 | 0.502 |
ACVR2A |
0.739 | -0.060 | -2 | 0.528 |
HPK1 |
0.738 | 0.179 | 1 | 0.836 |
MEK5 |
0.738 | 0.017 | 2 | 0.726 |
BUB1 |
0.737 | 0.184 | -5 | 0.812 |
GAK |
0.737 | 0.120 | 1 | 0.847 |
PLK4 |
0.737 | -0.057 | 2 | 0.575 |
PRP4 |
0.736 | -0.057 | -3 | 0.261 |
MEKK3 |
0.736 | -0.039 | 1 | 0.842 |
CK1G1 |
0.736 | -0.089 | -3 | 0.159 |
IRE2 |
0.736 | -0.020 | 2 | 0.619 |
MLK3 |
0.736 | -0.100 | 2 | 0.622 |
IRAK4 |
0.736 | 0.033 | 1 | 0.798 |
CHAK1 |
0.736 | -0.058 | 2 | 0.655 |
ERK1 |
0.736 | -0.011 | 1 | 0.647 |
CDK1 |
0.735 | -0.002 | 1 | 0.645 |
ERK2 |
0.735 | -0.008 | 1 | 0.683 |
BMPR1A |
0.735 | -0.021 | 1 | 0.816 |
P38G |
0.734 | 0.007 | 1 | 0.561 |
MPSK1 |
0.734 | 0.001 | 1 | 0.774 |
CAMKK2 |
0.733 | -0.022 | -2 | 0.597 |
LOK |
0.733 | 0.134 | -2 | 0.658 |
CDK17 |
0.732 | 0.004 | 1 | 0.560 |
GCK |
0.732 | 0.094 | 1 | 0.850 |
TLK2 |
0.732 | -0.132 | 1 | 0.800 |
CDK5 |
0.731 | -0.016 | 1 | 0.694 |
LKB1 |
0.731 | -0.022 | -3 | 0.315 |
IRAK1 |
0.731 | -0.033 | -1 | 0.790 |
TAO3 |
0.731 | 0.027 | 1 | 0.817 |
NEK5 |
0.730 | -0.104 | 1 | 0.837 |
NEK11 |
0.730 | -0.017 | 1 | 0.828 |
PBK |
0.730 | 0.116 | 1 | 0.768 |
MEKK1 |
0.729 | -0.128 | 1 | 0.836 |
MLK4 |
0.729 | -0.132 | 2 | 0.614 |
CDK2 |
0.729 | -0.034 | 1 | 0.730 |
PERK |
0.728 | -0.141 | -2 | 0.586 |
YANK3 |
0.728 | 0.063 | 2 | 0.386 |
ZAK |
0.727 | -0.106 | 1 | 0.816 |
TAK1 |
0.727 | 0.082 | 1 | 0.848 |
CK2A2 |
0.727 | 0.009 | 1 | 0.717 |
MEKK6 |
0.726 | 0.060 | 1 | 0.826 |
MEKK2 |
0.726 | -0.103 | 2 | 0.700 |
LRRK2 |
0.726 | 0.117 | 2 | 0.735 |
NEK8 |
0.726 | 0.041 | 2 | 0.701 |
CAMKK1 |
0.726 | -0.121 | -2 | 0.577 |
CDK4 |
0.726 | 0.076 | 1 | 0.613 |
TTBK1 |
0.725 | -0.095 | 2 | 0.551 |
KHS2 |
0.725 | 0.131 | 1 | 0.835 |
SLK |
0.725 | 0.048 | -2 | 0.582 |
JNK1 |
0.725 | 0.006 | 1 | 0.619 |
HRI |
0.725 | -0.148 | -2 | 0.602 |
TAO2 |
0.725 | 0.011 | 2 | 0.721 |
RIPK2 |
0.724 | 0.050 | 1 | 0.771 |
CDK3 |
0.724 | 0.002 | 1 | 0.578 |
KHS1 |
0.724 | 0.102 | 1 | 0.821 |
STK33 |
0.724 | 0.011 | 2 | 0.560 |
PINK1 |
0.723 | -0.132 | 1 | 0.801 |
TLK1 |
0.723 | -0.122 | -2 | 0.566 |
PLK2 |
0.723 | -0.059 | -3 | 0.246 |
CK2A1 |
0.721 | 0.017 | 1 | 0.699 |
P38D |
0.721 | -0.015 | 1 | 0.561 |
NEK4 |
0.720 | -0.061 | 1 | 0.816 |
CDK16 |
0.719 | -0.009 | 1 | 0.574 |
NEK1 |
0.719 | -0.029 | 1 | 0.817 |
MAP3K15 |
0.719 | -0.033 | 1 | 0.795 |
TNIK |
0.719 | 0.015 | 3 | 0.763 |
HASPIN |
0.718 | 0.124 | -1 | 0.747 |
HGK |
0.717 | -0.030 | 3 | 0.766 |
ERK7 |
0.717 | -0.025 | 2 | 0.445 |
MST2 |
0.717 | -0.114 | 1 | 0.850 |
VRK1 |
0.716 | -0.015 | 2 | 0.734 |
MINK |
0.716 | -0.037 | 1 | 0.831 |
MEK2 |
0.712 | -0.112 | 2 | 0.712 |
YSK1 |
0.711 | -0.003 | 2 | 0.678 |
CDK6 |
0.711 | -0.003 | 1 | 0.635 |
MST1 |
0.709 | -0.091 | 1 | 0.827 |
EEF2K |
0.709 | -0.080 | 3 | 0.730 |
CK1A |
0.709 | -0.079 | -3 | 0.090 |
PDHK3_TYR |
0.707 | 0.133 | 4 | 0.879 |
NEK3 |
0.704 | -0.082 | 1 | 0.784 |
BIKE |
0.701 | 0.016 | 1 | 0.725 |
MYO3B |
0.697 | 0.000 | 2 | 0.682 |
MAP2K4_TYR |
0.697 | 0.109 | -1 | 0.855 |
LIMK2_TYR |
0.697 | 0.168 | -3 | 0.407 |
TESK1_TYR |
0.697 | 0.096 | 3 | 0.815 |
PDHK4_TYR |
0.697 | 0.050 | 2 | 0.810 |
BMPR2_TYR |
0.697 | 0.072 | -1 | 0.869 |
ASK1 |
0.696 | -0.069 | 1 | 0.778 |
MAP2K6_TYR |
0.696 | 0.068 | -1 | 0.858 |
TAO1 |
0.696 | -0.001 | 1 | 0.752 |
MAP2K7_TYR |
0.695 | 0.072 | 2 | 0.774 |
TTK |
0.694 | -0.065 | -2 | 0.578 |
DDR2 |
0.693 | 0.213 | 3 | 0.691 |
DDR1 |
0.693 | 0.138 | 4 | 0.779 |
PKMYT1_TYR |
0.692 | 0.019 | 3 | 0.797 |
OSR1 |
0.692 | -0.116 | 2 | 0.690 |
PINK1_TYR |
0.691 | 0.164 | 1 | 0.839 |
EPHA6 |
0.691 | 0.064 | -1 | 0.852 |
ALPHAK3 |
0.690 | -0.062 | -1 | 0.735 |
EPHB4 |
0.689 | 0.015 | -1 | 0.832 |
PDHK1_TYR |
0.688 | -0.031 | -1 | 0.862 |
RET |
0.688 | 0.052 | 1 | 0.822 |
CK1G3 |
0.688 | -0.083 | -3 | 0.072 |
MYO3A |
0.687 | -0.059 | 1 | 0.804 |
TNK2 |
0.687 | 0.062 | 3 | 0.718 |
AAK1 |
0.684 | 0.024 | 1 | 0.620 |
LIMK1_TYR |
0.683 | 0.009 | 2 | 0.734 |
TXK |
0.682 | -0.002 | 1 | 0.879 |
EPHA4 |
0.682 | -0.009 | 2 | 0.750 |
MST1R |
0.682 | -0.022 | 3 | 0.757 |
TNK1 |
0.680 | 0.094 | 3 | 0.720 |
SRMS |
0.680 | -0.036 | 1 | 0.886 |
EPHB1 |
0.679 | -0.032 | 1 | 0.885 |
TYRO3 |
0.679 | -0.077 | 3 | 0.731 |
YANK2 |
0.678 | -0.036 | 2 | 0.397 |
STLK3 |
0.678 | -0.158 | 1 | 0.782 |
ITK |
0.678 | -0.016 | -1 | 0.817 |
EPHB3 |
0.677 | -0.034 | -1 | 0.824 |
EPHB2 |
0.676 | -0.046 | -1 | 0.811 |
AXL |
0.676 | -0.010 | 3 | 0.727 |
ROS1 |
0.675 | -0.081 | 3 | 0.709 |
INSRR |
0.675 | -0.037 | 3 | 0.695 |
YES1 |
0.675 | -0.064 | -1 | 0.830 |
JAK3 |
0.674 | -0.052 | 1 | 0.798 |
ABL2 |
0.674 | -0.061 | -1 | 0.783 |
MERTK |
0.673 | -0.044 | 3 | 0.726 |
FGFR2 |
0.673 | -0.026 | 3 | 0.749 |
TYK2 |
0.673 | -0.150 | 1 | 0.822 |
EPHA7 |
0.673 | -0.011 | 2 | 0.735 |
NEK10_TYR |
0.672 | 0.018 | 1 | 0.684 |
FGR |
0.672 | -0.098 | 1 | 0.883 |
BMX |
0.671 | -0.017 | -1 | 0.728 |
FER |
0.671 | -0.115 | 1 | 0.890 |
JAK2 |
0.671 | -0.164 | 1 | 0.824 |
EPHA1 |
0.671 | 0.005 | 3 | 0.714 |
CK1G2 |
0.670 | -0.074 | -3 | 0.117 |
KDR |
0.670 | -0.012 | 3 | 0.706 |
CSF1R |
0.670 | -0.127 | 3 | 0.733 |
TEK |
0.670 | -0.061 | 3 | 0.678 |
PTK2B |
0.669 | -0.002 | -1 | 0.771 |
ABL1 |
0.669 | -0.079 | -1 | 0.775 |
EPHA3 |
0.669 | -0.046 | 2 | 0.716 |
PDGFRB |
0.668 | -0.070 | 3 | 0.744 |
TNNI3K_TYR |
0.667 | -0.023 | 1 | 0.843 |
EPHA5 |
0.666 | -0.023 | 2 | 0.744 |
LTK |
0.666 | -0.020 | 3 | 0.699 |
HCK |
0.665 | -0.130 | -1 | 0.836 |
TEC |
0.665 | -0.057 | -1 | 0.744 |
LCK |
0.665 | -0.085 | -1 | 0.836 |
BLK |
0.665 | -0.059 | -1 | 0.836 |
FYN |
0.664 | -0.044 | -1 | 0.816 |
FGFR1 |
0.664 | -0.103 | 3 | 0.718 |
MET |
0.664 | -0.083 | 3 | 0.737 |
KIT |
0.663 | -0.116 | 3 | 0.737 |
FGFR3 |
0.662 | -0.056 | 3 | 0.722 |
PTK2 |
0.662 | 0.020 | -1 | 0.802 |
ALK |
0.661 | -0.065 | 3 | 0.675 |
BTK |
0.661 | -0.126 | -1 | 0.786 |
FLT1 |
0.661 | -0.055 | -1 | 0.805 |
NTRK1 |
0.661 | -0.122 | -1 | 0.789 |
JAK1 |
0.661 | -0.101 | 1 | 0.780 |
FLT3 |
0.660 | -0.102 | 3 | 0.728 |
WEE1_TYR |
0.660 | -0.044 | -1 | 0.749 |
EPHA8 |
0.660 | -0.053 | -1 | 0.807 |
PDGFRA |
0.657 | -0.139 | 3 | 0.737 |
ERBB2 |
0.656 | -0.123 | 1 | 0.786 |
FLT4 |
0.655 | -0.081 | 3 | 0.700 |
INSR |
0.654 | -0.125 | 3 | 0.673 |
FRK |
0.654 | -0.114 | -1 | 0.837 |
PTK6 |
0.653 | -0.165 | -1 | 0.722 |
NTRK2 |
0.653 | -0.158 | 3 | 0.708 |
EPHA2 |
0.652 | -0.044 | -1 | 0.771 |
CSK |
0.652 | -0.089 | 2 | 0.734 |
NTRK3 |
0.652 | -0.133 | -1 | 0.737 |
SYK |
0.651 | -0.044 | -1 | 0.763 |
SRC |
0.651 | -0.097 | -1 | 0.796 |
LYN |
0.650 | -0.138 | 3 | 0.667 |
MATK |
0.649 | -0.100 | -1 | 0.690 |
EGFR |
0.645 | -0.107 | 1 | 0.704 |
FGFR4 |
0.645 | -0.109 | -1 | 0.728 |
ERBB4 |
0.641 | -0.073 | 1 | 0.733 |
IGF1R |
0.641 | -0.108 | 3 | 0.623 |
MUSK |
0.631 | -0.126 | 1 | 0.684 |
FES |
0.631 | -0.118 | -1 | 0.694 |
ZAP70 |
0.625 | -0.069 | -1 | 0.689 |