Motif 330 (n=137)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | Y453 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A6NDE4 | RBMY1B | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member B | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| A6NEQ0 | RBMY1E | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member E | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| O00461 | GOLIM4 | S538 | ochoa | Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa) | Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. {ECO:0000269|PubMed:15331763}. |
| O15160 | POLR1C | S157 | ochoa | DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft. {ECO:0000250|UniProtKB:P07703, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492, ECO:0000305|PubMed:26151409}. |
| O43295 | SRGAP3 | S919 | ochoa | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}. |
| O60292 | SIPA1L3 | S1707 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60566 | BUB1B | S683 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O95049 | TJP3 | S36 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95049 | TJP3 | S864 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95817 | BAG3 | S224 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P02686 | MBP | S205 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P07355 | ANXA2 | S184 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07437 | TUBB | Y106 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0C7P1 | RBMY1D | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member D | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| P0C7U0 | ELFN1 | S623 | ochoa | Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28) | Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}. |
| P0DJD3 | RBMY1A1 | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}. |
| P0DJD4 | RBMY1C | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member C | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
| P10909 | CLU | S391 | ochoa | Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)] | [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17407782, PubMed:17412999). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex (PubMed:2780565, PubMed:1903064, PubMed:2601725, PubMed:2721499, PubMed:1551440, PubMed:9200695, PubMed:34667172). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). {ECO:0000250|UniProtKB:P05371, ECO:0000250|UniProtKB:Q06890, ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:1903064, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260, ECO:0000269|PubMed:2601725, ECO:0000269|PubMed:2721499, ECO:0000269|PubMed:2780565, ECO:0000269|PubMed:34667172, ECO:0000269|PubMed:9200695}.; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. {ECO:0000269|PubMed:24073260}.; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405). {ECO:0000269|PubMed:21567405, ECO:0000269|PubMed:24073260}. |
| P13611 | VCAN | S566 | ochoa | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) | May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. |
| P13796 | LCP1 | S418 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P14317 | HCLS1 | S97 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P18206 | VCL | S755 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P22090 | RPS4Y1 | S204 | ochoa | Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4) | None |
| P25100 | ADRA1D | T328 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P28290 | ITPRID2 | S1060 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28715 | ERCC5 | S526 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P36956 | SREBF1 | S394 | ochoa | Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] | [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}. |
| P37059 | HSD17B2 | S234 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
| P41212 | ETV6 | S139 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P46100 | ATRX | S1253 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P52732 | KIF11 | S39 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P54252 | ATXN3 | S256 | psp | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P55211 | CASP9 | S99 | psp | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}. |
| P62701 | RPS4X | S204 | ochoa | Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P62879 | GNB2 | S28 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| P68371 | TUBB4B | Y106 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q05BQ5 | MBTD1 | S309 | ochoa | MBT domain-containing protein 1 | Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:27153538, PubMed:32209463). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively) (PubMed:19841675, PubMed:27153538, PubMed:32209463). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me (PubMed:27153538). Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR) (PubMed:27153538). {ECO:0000269|PubMed:19841675, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
| Q07817 | BCL2L1 | S145 | psp | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.; FUNCTION: Isoform Bcl-X(S) promotes apoptosis. |
| Q08289 | CACNB2 | S512 | ochoa | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}. |
| Q12929 | EPS8 | S577 | psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13309 | SKP2 | S179 | ochoa | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}. |
| Q13470 | TNK1 | S582 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q13509 | TUBB3 | Y106 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | Y106 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14157 | UBAP2L | S356 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14573 | ITPR3 | S1847 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q14940 | SLC9A5 | S618 | psp | Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:10692428, PubMed:19276089, PubMed:24936055, PubMed:9933641). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:21551074, PubMed:24006492). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055). {ECO:0000269|PubMed:10692428, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24006492, ECO:0000269|PubMed:24936055, ECO:0000269|PubMed:9933641}. |
| Q15334 | LLGL1 | S961 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15415 | RBMY1F | S474 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2) | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. {ECO:0000269|PubMed:8269511}. |
| Q15772 | SPEG | S2109 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16891 | IMMT | S356 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q52LD8 | RFTN2 | S470 | ochoa | Raftlin-2 (Raft-linking protein 2) | Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}. |
| Q5QJE6 | DNTTIP2 | S434 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T5P2 | KIAA1217 | S531 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5VST9 | OBSCN | S790 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VST9 | OBSCN | S5955 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT25 | CDC42BPA | S222 | psp | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q6IBW4 | NCAPH2 | S95 | psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6PJG2 | MIDEAS | S718 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6ZU80 | CEP128 | S1061 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q7Z2K8 | GPRIN1 | S444 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z628 | NET1 | S24 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q7Z628 | NET1 | S542 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q7Z6J6 | FRMD5 | S375 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q86V87 | FHIP2B | S526 | ochoa | FHF complex subunit HOOK-interacting protein 2B (FHIP2B) (Retinoic acid-induced protein 16) | Able to activate MAPK/ERK and TGFB signaling pathways (PubMed:22971576). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (By similarity). May play a role in cell proliferation (PubMed:22971576). {ECO:0000250|UniProtKB:Q80YR2, ECO:0000269|PubMed:22971576}. |
| Q8N3S3 | PHTF2 | S222 | ochoa | Protein PHTF2 | None |
| Q8N3Y1 | FBXW8 | S545 | ochoa | F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29) | Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17205132, PubMed:18498745, PubMed:21572988, PubMed:24362026, PubMed:35982156). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). The Cul7-RING(FBXW8) complex also mediates ubiquitination of phosphorylated cyclin-D1 (CCND1) (PubMed:17205132). The Cul7-RING(FBXW8) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000250|UniProtKB:Q8BIA4, ECO:0000269|PubMed:17205132, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:35982156}. |
| Q8N5H3 | FAM89B | S37 | ochoa | Leucine repeat adapter protein 25 | Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. {ECO:0000250|UniProtKB:Q9QUI1}. |
| Q8N5V2 | NGEF | S606 | ochoa | Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) | Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}. |
| Q8N8S7 | ENAH | S463 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8NCF5 | NFATC2IP | S345 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8TBB6 | SLC7A14 | S691 | ochoa | Solute carrier family 7 member 14 (Gamma-aminobutyric acid transporter SLC7A14) | Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated. {ECO:0000250|UniProtKB:Q8BXR1}. |
| Q8TEW0 | PARD3 | S932 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF76 | HASPIN | S317 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUM0 | NUP133 | S472 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q96IQ7 | VSIG2 | S293 | ochoa | V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein) | None |
| Q96J84 | KIRREL1 | S560 | ochoa | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}. |
| Q96JQ0 | DCHS1 | S3058 | ochoa | Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) | Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}. |
| Q96MG2 | JSRP1 | S46 | ochoa | Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
| Q96S82 | UBL7 | S123 | ochoa | Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132) | Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. {ECO:0000269|PubMed:19690332}. |
| Q96T58 | SPEN | S2305 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99460 | PSMD1 | S363 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q99640 | PKMYT1 | S469 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q9BRD0 | BUD13 | S271 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BV36 | MLPH | S155 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BVA1 | TUBB2B | Y106 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BVW5 | TIPIN | S220 | ochoa | TIMELESS-interacting protein | Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232). {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:35585232}. |
| Q9BWT3 | PAPOLG | S450 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BYW2 | SETD2 | S2104 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C0B1 | FTO | S184 | ochoa | Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
| Q9H244 | P2RY12 | S323 | ochoa | P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) | Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}. |
| Q9H7Z7 | PTGES2 | S95 | ochoa | Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:17585783, PubMed:18198127). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:17585783, PubMed:18198127). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity) (PubMed:17585783). {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}. |
| Q9HC77 | CPAP | S681 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NPI6 | DCP1A | S150 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NQS5 | GPR84 | S224 | psp | G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33) | G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists (PubMed:16966319). In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (By similarity). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (By similarity). Also plays an important role in inflammation by modulating neutrophil functions (By similarity). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (By similarity). To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils (PubMed:33789297). {ECO:0000250|UniProtKB:Q8CIM5, ECO:0000269|PubMed:16966319, ECO:0000269|PubMed:33789297}. |
| Q9NRX1 | PNO1 | S36 | ochoa | RNA-binding protein PNO1 (Partner of NOB1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604). {ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:34516797}. |
| Q9NUQ8 | ABCF3 | S79 | ochoa | ATP-binding cassette sub-family F member 3 | Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}. |
| Q9NV88 | INTS9 | S564 | ochoa | Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:22252320, PubMed:26308897, PubMed:30737432). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:22252320, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33548203, ECO:0000269|PubMed:38570683}. |
| Q9NWH9 | SLTM | S742 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NX61 | TMEM161A | S69 | ochoa | Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29) | May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}. |
| Q9NYQ6 | CELSR1 | S2758 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZJ4 | SACS | S1779 | ochoa | Sacsin (DnaJ homolog subfamily C member 29) | Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. {ECO:0000269|PubMed:19208651}. |
| Q9P2D1 | CHD7 | S2141 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UBC2 | EPS15L1 | S575 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UDY2 | TJP2 | S913 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHV5 | RAPGEFL1 | S313 | ochoa | Rap guanine nucleotide exchange factor-like 1 (Link guanine nucleotide exchange factor II) (Link GEFII) | Probable guanine nucleotide exchange factor (GEF). |
| Q9UJW0 | DCTN4 | S198 | ochoa | Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:A0A4X1TB62}. |
| Q9UNF1 | MAGED2 | S264 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9Y2K1 | ZBTB1 | S179 | ochoa | Zinc finger and BTB domain-containing protein 1 | Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}. |
| Q9Y2L6 | FRMD4B | S627 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y446 | PKP3 | S80 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4J8 | DTNA | S608 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y580 | RBM7 | S149 | ochoa | RNA-binding protein 7 (RNA-binding motif protein 7) | RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104, PubMed:27871484). NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:25189701, PubMed:25852104, PubMed:27871484). Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104). Participates in several biological processes including DNA damage response (DDR) and stress response (PubMed:25525152, PubMed:30824372). During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome (PubMed:25525152). Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability (PubMed:30824372). {ECO:0000269|PubMed:25189701, ECO:0000269|PubMed:25525152, ECO:0000269|PubMed:25578728, ECO:0000269|PubMed:25852104, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:30824372}. |
| Q9Y6E0 | STK24 | S294 | ochoa | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
| R4GMW8 | BIVM-ERCC5 | S980 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q9NYB9 | ABI2 | S22 | Sugiyama | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| P33240 | CSTF2 | S336 | Sugiyama | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| Q08209 | PPP3CA | S498 | Sugiyama | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}. |
| Q9H0L4 | CSTF2T | S344 | Sugiyama | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}. |
| P11047 | LAMC1 | S335 | Sugiyama | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| O60279 | SUSD5 | S70 | Sugiyama | Sushi domain-containing protein 5 | None |
| P41594 | GRM5 | S840 | SIGNOR|iPTMNet|EPSD | Metabotropic glutamate receptor 5 (mGluR5) | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}. |
| Q9UHX1 | PUF60 | S232 | Sugiyama | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| P18206 | VCL | S1113 | GPS6|SIGNOR|ELM|EPSD | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P62714 | PPP2CB | S212 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
| P67775 | PPP2CA | S212 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}. |
| O43707 | ACTN4 | S763 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| P12814 | ACTN1 | S744 | Sugiyama | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| Q9Y4W2 | LAS1L | S636 | Sugiyama | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q13043 | STK4 | S288 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| P23381 | WARS1 | S139 | Sugiyama | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}.; FUNCTION: [Isoform 1]: Has no angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953). {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:14630953}.; FUNCTION: [Isoform 2]: Has an angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}. |
| P55072 | VCP | S459 | Sugiyama | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| Q9BRK5 | SDF4 | S142 | Sugiyama | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
| Q9BTC0 | DIDO1 | S975 | Sugiyama | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9Y5S2 | CDC42BPB | S221 | Sugiyama | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| P27540 | ARNT | S57 | Sugiyama | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881, ECO:0000305|PubMed:34521881}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.000002 | 5.636 |
| R-HSA-9646399 | Aggrephagy | 0.000006 | 5.226 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.000002 | 5.636 |
| R-HSA-68877 | Mitotic Prometaphase | 0.000005 | 5.270 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.000003 | 5.543 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.000006 | 5.255 |
| R-HSA-69275 | G2/M Transition | 0.000004 | 5.406 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.000004 | 5.367 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.000009 | 5.050 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.000021 | 4.683 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.000019 | 4.730 |
| R-HSA-9833482 | PKR-mediated signaling | 0.000021 | 4.683 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.000031 | 4.515 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.000036 | 4.448 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.000038 | 4.417 |
| R-HSA-983189 | Kinesins | 0.000046 | 4.333 |
| R-HSA-190861 | Gap junction assembly | 0.000045 | 4.346 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.000054 | 4.264 |
| R-HSA-68882 | Mitotic Anaphase | 0.000079 | 4.105 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.000081 | 4.090 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.000085 | 4.069 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.000096 | 4.019 |
| R-HSA-68886 | M Phase | 0.000106 | 3.973 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.000104 | 3.984 |
| R-HSA-190828 | Gap junction trafficking | 0.000137 | 3.865 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.000168 | 3.774 |
| R-HSA-9675108 | Nervous system development | 0.000162 | 3.789 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.000177 | 3.753 |
| R-HSA-437239 | Recycling pathway of L1 | 0.000177 | 3.753 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.000192 | 3.718 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.000208 | 3.681 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.000222 | 3.653 |
| R-HSA-5689877 | Josephin domain DUBs | 0.000260 | 3.585 |
| R-HSA-422475 | Axon guidance | 0.000266 | 3.576 |
| R-HSA-9663891 | Selective autophagy | 0.000315 | 3.502 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.000316 | 3.500 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000389 | 3.410 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.000422 | 3.375 |
| R-HSA-1640170 | Cell Cycle | 0.000450 | 3.347 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.000499 | 3.302 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.000526 | 3.279 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.000526 | 3.279 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.000474 | 3.324 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.000906 | 3.043 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.001070 | 2.971 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.001011 | 2.995 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.001315 | 2.881 |
| R-HSA-109582 | Hemostasis | 0.001335 | 2.875 |
| R-HSA-373760 | L1CAM interactions | 0.001423 | 2.847 |
| R-HSA-373753 | Nephrin family interactions | 0.001707 | 2.768 |
| R-HSA-5620924 | Intraflagellar transport | 0.001932 | 2.714 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.002118 | 2.674 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.002118 | 2.674 |
| R-HSA-391251 | Protein folding | 0.002745 | 2.561 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.003392 | 2.470 |
| R-HSA-5617833 | Cilium Assembly | 0.003516 | 2.454 |
| R-HSA-1632852 | Macroautophagy | 0.003721 | 2.429 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.003923 | 2.406 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.004002 | 2.398 |
| R-HSA-180024 | DARPP-32 events | 0.004380 | 2.359 |
| R-HSA-111885 | Opioid Signalling | 0.004548 | 2.342 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.004581 | 2.339 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.004227 | 2.374 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.004813 | 2.318 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.004947 | 2.306 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.005133 | 2.290 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.005694 | 2.245 |
| R-HSA-9612973 | Autophagy | 0.005891 | 2.230 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.005900 | 2.229 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.007657 | 2.116 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.007657 | 2.116 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.007657 | 2.116 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.008737 | 2.059 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.006208 | 2.207 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.006208 | 2.207 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.007223 | 2.141 |
| R-HSA-4839744 | Signaling by APC mutants | 0.007657 | 2.116 |
| R-HSA-202670 | ERKs are inactivated | 0.008737 | 2.059 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.008737 | 2.059 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.008737 | 2.059 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.008737 | 2.059 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.006764 | 2.170 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.006628 | 2.179 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.007699 | 2.114 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.006354 | 2.197 |
| R-HSA-109581 | Apoptosis | 0.006905 | 2.161 |
| R-HSA-2262752 | Cellular responses to stress | 0.007775 | 2.109 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.008026 | 2.095 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.009755 | 2.011 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.009881 | 2.005 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.009881 | 2.005 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.009881 | 2.005 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.009881 | 2.005 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.009881 | 2.005 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.011732 | 1.931 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.011732 | 1.931 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.012356 | 1.908 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.011088 | 1.955 |
| R-HSA-114608 | Platelet degranulation | 0.010727 | 1.970 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.011088 | 1.955 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.010946 | 1.961 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.012585 | 1.900 |
| R-HSA-69236 | G1 Phase | 0.012823 | 1.892 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.012823 | 1.892 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.012969 | 1.887 |
| R-HSA-8953854 | Metabolism of RNA | 0.013423 | 1.872 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.013685 | 1.864 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.013685 | 1.864 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.014171 | 1.849 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.014323 | 1.844 |
| R-HSA-163685 | Integration of energy metabolism | 0.014384 | 1.842 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.016518 | 1.782 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.015128 | 1.820 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.015072 | 1.822 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.015072 | 1.822 |
| R-HSA-9609690 | HCMV Early Events | 0.015471 | 1.810 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.016518 | 1.782 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.017458 | 1.758 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.017805 | 1.749 |
| R-HSA-2028269 | Signaling by Hippo | 0.018020 | 1.744 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.018337 | 1.737 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.018337 | 1.737 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.018337 | 1.737 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.018337 | 1.737 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.018337 | 1.737 |
| R-HSA-5357801 | Programmed Cell Death | 0.018876 | 1.724 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.019578 | 1.708 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.024574 | 1.610 |
| R-HSA-72649 | Translation initiation complex formation | 0.020340 | 1.692 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.022079 | 1.656 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.020253 | 1.694 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.022856 | 1.641 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.023896 | 1.622 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.022692 | 1.644 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.021191 | 1.674 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.022079 | 1.656 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.020340 | 1.692 |
| R-HSA-198753 | ERK/MAPK targets | 0.024574 | 1.610 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.022079 | 1.656 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.021545 | 1.667 |
| R-HSA-418346 | Platelet homeostasis | 0.024634 | 1.608 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.024634 | 1.608 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 0.027380 | 1.563 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.028783 | 1.541 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.028783 | 1.541 |
| R-HSA-162582 | Signal Transduction | 0.029300 | 1.533 |
| R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 0.036340 | 1.440 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.031950 | 1.496 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.035293 | 1.452 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.040018 | 1.398 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.035918 | 1.445 |
| R-HSA-6798695 | Neutrophil degranulation | 0.034466 | 1.463 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.036445 | 1.438 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.040069 | 1.397 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.042210 | 1.375 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.031922 | 1.496 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.031946 | 1.496 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.037617 | 1.425 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.037617 | 1.425 |
| R-HSA-4086398 | Ca2+ pathway | 0.040018 | 1.398 |
| R-HSA-68875 | Mitotic Prophase | 0.036657 | 1.436 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.037971 | 1.421 |
| R-HSA-9609646 | HCMV Infection | 0.040500 | 1.393 |
| R-HSA-1280218 | Adaptive Immune System | 0.038880 | 1.410 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.031946 | 1.496 |
| R-HSA-69206 | G1/S Transition | 0.041900 | 1.378 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.035918 | 1.445 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.042210 | 1.375 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.040018 | 1.398 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.041243 | 1.385 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.035093 | 1.455 |
| R-HSA-913531 | Interferon Signaling | 0.035069 | 1.455 |
| R-HSA-380287 | Centrosome maturation | 0.042496 | 1.372 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.042496 | 1.372 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.044226 | 1.354 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.044392 | 1.353 |
| R-HSA-844455 | The NLRP1 inflammasome | 0.045218 | 1.345 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.045515 | 1.342 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.046616 | 1.331 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.048879 | 1.311 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.048879 | 1.311 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.048879 | 1.311 |
| R-HSA-9930044 | Nuclear RNA decay | 0.051182 | 1.291 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.051182 | 1.291 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.052308 | 1.281 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.053523 | 1.271 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.054014 | 1.267 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.054565 | 1.263 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.054642 | 1.262 |
| R-HSA-392518 | Signal amplification | 0.055902 | 1.253 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.055902 | 1.253 |
| R-HSA-5673000 | RAF activation | 0.055902 | 1.253 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.062731 | 1.203 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.071367 | 1.147 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 0.079925 | 1.097 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 0.079925 | 1.097 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.066516 | 1.177 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.068088 | 1.167 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.074542 | 1.128 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.076197 | 1.118 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.064962 | 1.187 |
| R-HSA-166665 | Terminal pathway of complement | 0.071367 | 1.147 |
| R-HSA-156902 | Peptide chain elongation | 0.061904 | 1.208 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.060461 | 1.219 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.073527 | 1.134 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.076197 | 1.118 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.081558 | 1.089 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.084293 | 1.074 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.079925 | 1.097 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.069677 | 1.157 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.078852 | 1.103 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.071367 | 1.147 |
| R-HSA-422356 | Regulation of insulin secretion | 0.081258 | 1.090 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.062731 | 1.203 |
| R-HSA-388396 | GPCR downstream signalling | 0.066090 | 1.180 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.077873 | 1.109 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.062731 | 1.203 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.071367 | 1.147 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.071367 | 1.147 |
| R-HSA-195721 | Signaling by WNT | 0.076234 | 1.118 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.081558 | 1.089 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.077868 | 1.109 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.074115 | 1.130 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.076174 | 1.118 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.062218 | 1.206 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.066885 | 1.175 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.060768 | 1.216 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.076174 | 1.118 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.082977 | 1.081 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.068326 | 1.165 |
| R-HSA-168249 | Innate Immune System | 0.074684 | 1.127 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.082977 | 1.081 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.083065 | 1.081 |
| R-HSA-70171 | Glycolysis | 0.084711 | 1.072 |
| R-HSA-112316 | Neuronal System | 0.085441 | 1.068 |
| R-HSA-72312 | rRNA processing | 0.085926 | 1.066 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.086461 | 1.063 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.087055 | 1.060 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.087055 | 1.060 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 0.088404 | 1.054 |
| R-HSA-75153 | Apoptotic execution phase | 0.089845 | 1.047 |
| R-HSA-192823 | Viral mRNA Translation | 0.090006 | 1.046 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.091802 | 1.037 |
| R-HSA-1500931 | Cell-Cell communication | 0.093141 | 1.031 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.095502 | 1.020 |
| R-HSA-390696 | Adrenoceptors | 0.096805 | 1.014 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.096805 | 1.014 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.096805 | 1.014 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.099131 | 1.004 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.100999 | 0.996 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.100999 | 0.996 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.121551 | 0.915 |
| R-HSA-2022923 | DS-GAG biosynthesis | 0.129649 | 0.887 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.161306 | 0.792 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.161306 | 0.792 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.161306 | 0.792 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.169040 | 0.772 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.176703 | 0.753 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.176703 | 0.753 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.176703 | 0.753 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.184296 | 0.734 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.191819 | 0.717 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.191819 | 0.717 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.107108 | 0.970 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.110067 | 0.958 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.140731 | 0.852 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.192817 | 0.715 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.129649 | 0.887 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.113378 | 0.945 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.129649 | 0.887 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.176703 | 0.753 |
| R-HSA-111458 | Formation of apoptosome | 0.113378 | 0.945 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.107108 | 0.970 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.105130 | 0.978 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.176703 | 0.753 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.176703 | 0.753 |
| R-HSA-72187 | mRNA 3'-end processing | 0.107108 | 0.970 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.110067 | 0.958 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.116048 | 0.935 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.199274 | 0.701 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.120433 | 0.919 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.119069 | 0.924 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.120433 | 0.919 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.105130 | 0.978 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.191819 | 0.717 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.107108 | 0.970 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.134456 | 0.871 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.191819 | 0.717 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.147068 | 0.832 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.161306 | 0.792 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.176703 | 0.753 |
| R-HSA-8951664 | Neddylation | 0.185407 | 0.732 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.110067 | 0.958 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.172952 | 0.762 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.137585 | 0.861 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.156681 | 0.805 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.104172 | 0.982 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.105130 | 0.978 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.161306 | 0.792 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.199274 | 0.701 |
| R-HSA-9659379 | Sensory processing of sound | 0.192817 | 0.715 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.137585 | 0.861 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.169675 | 0.770 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.184296 | 0.734 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.163154 | 0.787 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.163154 | 0.787 |
| R-HSA-397014 | Muscle contraction | 0.169066 | 0.772 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.122109 | 0.913 |
| R-HSA-3928664 | Ephrin signaling | 0.191819 | 0.717 |
| R-HSA-5619084 | ABC transporter disorders | 0.189484 | 0.722 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.159875 | 0.796 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.134456 | 0.871 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.161306 | 0.792 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.170362 | 0.769 |
| R-HSA-417957 | P2Y receptors | 0.153501 | 0.814 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.196157 | 0.707 |
| R-HSA-372790 | Signaling by GPCR | 0.114966 | 0.939 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.119069 | 0.924 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.191819 | 0.717 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.126585 | 0.898 |
| R-HSA-5688426 | Deubiquitination | 0.113127 | 0.946 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.196157 | 0.707 |
| R-HSA-199991 | Membrane Trafficking | 0.168758 | 0.773 |
| R-HSA-193144 | Estrogen biosynthesis | 0.137673 | 0.861 |
| R-HSA-168255 | Influenza Infection | 0.112727 | 0.948 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.169675 | 0.770 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.137673 | 0.861 |
| R-HSA-8876725 | Protein methylation | 0.161306 | 0.792 |
| R-HSA-3371556 | Cellular response to heat stress | 0.130631 | 0.884 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.161306 | 0.792 |
| R-HSA-9678110 | Attachment and Entry | 0.169040 | 0.772 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.199274 | 0.701 |
| R-HSA-3000178 | ECM proteoglycans | 0.166409 | 0.779 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.103236 | 0.986 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.137673 | 0.861 |
| R-HSA-70326 | Glucose metabolism | 0.122449 | 0.912 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.191819 | 0.717 |
| R-HSA-9909396 | Circadian clock | 0.158467 | 0.800 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.118431 | 0.927 |
| R-HSA-73942 | DNA Damage Reversal | 0.161306 | 0.792 |
| R-HSA-194138 | Signaling by VEGF | 0.141122 | 0.850 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.121551 | 0.915 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.198462 | 0.702 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.143892 | 0.842 |
| R-HSA-1266738 | Developmental Biology | 0.202237 | 0.694 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.130631 | 0.884 |
| R-HSA-168256 | Immune System | 0.112338 | 0.949 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.186160 | 0.730 |
| R-HSA-450294 | MAP kinase activation | 0.134456 | 0.871 |
| R-HSA-448424 | Interleukin-17 signaling | 0.163154 | 0.787 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.169675 | 0.770 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.118335 | 0.927 |
| R-HSA-449147 | Signaling by Interleukins | 0.146157 | 0.835 |
| R-HSA-418594 | G alpha (i) signalling events | 0.206499 | 0.685 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.209102 | 0.680 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.212960 | 0.672 |
| R-HSA-73887 | Death Receptor Signaling | 0.213878 | 0.670 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.213978 | 0.670 |
| R-HSA-202040 | G-protein activation | 0.213978 | 0.670 |
| R-HSA-1989781 | PPARA activates gene expression | 0.216275 | 0.665 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.216339 | 0.665 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.221087 | 0.655 |
| R-HSA-2022870 | CS-GAG biosynthesis | 0.221230 | 0.655 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.221230 | 0.655 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.221230 | 0.655 |
| R-HSA-9694614 | Attachment and Entry | 0.221230 | 0.655 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.221230 | 0.655 |
| R-HSA-9711097 | Cellular response to starvation | 0.223501 | 0.651 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.223501 | 0.651 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.228414 | 0.641 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.228414 | 0.641 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.228414 | 0.641 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.235533 | 0.628 |
| R-HSA-3000170 | Syndecan interactions | 0.235533 | 0.628 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.235533 | 0.628 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.236698 | 0.626 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.238091 | 0.623 |
| R-HSA-72766 | Translation | 0.239022 | 0.622 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.242587 | 0.615 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.242587 | 0.615 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.243510 | 0.613 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.245111 | 0.611 |
| R-HSA-5619102 | SLC transporter disorders | 0.245448 | 0.610 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.249576 | 0.603 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.249576 | 0.603 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.249576 | 0.603 |
| R-HSA-3000157 | Laminin interactions | 0.249576 | 0.603 |
| R-HSA-420029 | Tight junction interactions | 0.249576 | 0.603 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.249576 | 0.603 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.253143 | 0.597 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.256501 | 0.591 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.256501 | 0.591 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.256501 | 0.591 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.256501 | 0.591 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.256501 | 0.591 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.257158 | 0.590 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.257204 | 0.590 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.257788 | 0.589 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.263363 | 0.579 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.263363 | 0.579 |
| R-HSA-8949613 | Cristae formation | 0.263363 | 0.579 |
| R-HSA-9824446 | Viral Infection Pathways | 0.265289 | 0.576 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.267403 | 0.573 |
| R-HSA-190236 | Signaling by FGFR | 0.267403 | 0.573 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.267403 | 0.573 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.267403 | 0.573 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.267403 | 0.573 |
| R-HSA-416476 | G alpha (q) signalling events | 0.269334 | 0.570 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.270162 | 0.568 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.270162 | 0.568 |
| R-HSA-622312 | Inflammasomes | 0.270162 | 0.568 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.274234 | 0.562 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.276898 | 0.558 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.276898 | 0.558 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.281062 | 0.551 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.283573 | 0.547 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.283573 | 0.547 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.283573 | 0.547 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.283573 | 0.547 |
| R-HSA-9679506 | SARS-CoV Infections | 0.285518 | 0.544 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.287716 | 0.541 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.290186 | 0.537 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.290186 | 0.537 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.290186 | 0.537 |
| R-HSA-182971 | EGFR downregulation | 0.290186 | 0.537 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.294701 | 0.531 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.296739 | 0.528 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.296739 | 0.528 |
| R-HSA-446728 | Cell junction organization | 0.298083 | 0.526 |
| R-HSA-69239 | Synthesis of DNA | 0.301509 | 0.521 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.303232 | 0.518 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.303232 | 0.518 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.303232 | 0.518 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.304909 | 0.516 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.308306 | 0.511 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.309665 | 0.509 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.309665 | 0.509 |
| R-HSA-2024101 | CS/DS degradation | 0.309665 | 0.509 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.309665 | 0.509 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.309665 | 0.509 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.309665 | 0.509 |
| R-HSA-202403 | TCR signaling | 0.311700 | 0.506 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.311700 | 0.506 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.311700 | 0.506 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.315384 | 0.501 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.316039 | 0.500 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.316039 | 0.500 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.316039 | 0.500 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.316039 | 0.500 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.316039 | 0.500 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.316039 | 0.500 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.316039 | 0.500 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.316039 | 0.500 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.316039 | 0.500 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.321860 | 0.492 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.322354 | 0.492 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.322354 | 0.492 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.322354 | 0.492 |
| R-HSA-169911 | Regulation of Apoptosis | 0.322354 | 0.492 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.328612 | 0.483 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.328612 | 0.483 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.328612 | 0.483 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.328612 | 0.483 |
| R-HSA-3371511 | HSF1 activation | 0.328612 | 0.483 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.328614 | 0.483 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.331984 | 0.479 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.333462 | 0.477 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.334813 | 0.475 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.334813 | 0.475 |
| R-HSA-4641258 | Degradation of DVL | 0.334813 | 0.475 |
| R-HSA-4641257 | Degradation of AXIN | 0.334813 | 0.475 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.334813 | 0.475 |
| R-HSA-419037 | NCAM1 interactions | 0.334813 | 0.475 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.334813 | 0.475 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.335349 | 0.475 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.338075 | 0.471 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.340956 | 0.467 |
| R-HSA-9931953 | Biofilm formation | 0.340956 | 0.467 |
| R-HSA-8875878 | MET promotes cell motility | 0.340956 | 0.467 |
| R-HSA-72172 | mRNA Splicing | 0.343115 | 0.465 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.347043 | 0.460 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.347043 | 0.460 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.347043 | 0.460 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.347043 | 0.460 |
| R-HSA-69541 | Stabilization of p53 | 0.347043 | 0.460 |
| R-HSA-9648002 | RAS processing | 0.347043 | 0.460 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.348760 | 0.457 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.348760 | 0.457 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.348760 | 0.457 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.353074 | 0.452 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.353074 | 0.452 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.353074 | 0.452 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.353074 | 0.452 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.353074 | 0.452 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.353074 | 0.452 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.353074 | 0.452 |
| R-HSA-202433 | Generation of second messenger molecules | 0.353074 | 0.452 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.358760 | 0.445 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.358760 | 0.445 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.359050 | 0.445 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.359050 | 0.445 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.359050 | 0.445 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.359050 | 0.445 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.359050 | 0.445 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.359050 | 0.445 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.359050 | 0.445 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.360334 | 0.443 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.362082 | 0.441 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.364971 | 0.438 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.364971 | 0.438 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.364971 | 0.438 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.364971 | 0.438 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.364971 | 0.438 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.364971 | 0.438 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.364971 | 0.438 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.365397 | 0.437 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.370838 | 0.431 |
| R-HSA-991365 | Activation of GABAB receptors | 0.370838 | 0.431 |
| R-HSA-977444 | GABA B receptor activation | 0.370838 | 0.431 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.370838 | 0.431 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.371785 | 0.430 |
| R-HSA-69481 | G2/M Checkpoints | 0.378590 | 0.422 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.381870 | 0.418 |
| R-HSA-9907900 | Proteasome assembly | 0.382410 | 0.417 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.382410 | 0.417 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.388117 | 0.411 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.388117 | 0.411 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.388117 | 0.411 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.388117 | 0.411 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.388117 | 0.411 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.388117 | 0.411 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.388117 | 0.411 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.388117 | 0.411 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.388117 | 0.411 |
| R-HSA-9824272 | Somitogenesis | 0.388117 | 0.411 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.388117 | 0.411 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.388410 | 0.411 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.393771 | 0.405 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.393771 | 0.405 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.393771 | 0.405 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.393771 | 0.405 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.393771 | 0.405 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.393771 | 0.405 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.393771 | 0.405 |
| R-HSA-8957322 | Metabolism of steroids | 0.394130 | 0.404 |
| R-HSA-5576891 | Cardiac conduction | 0.394920 | 0.403 |
| R-HSA-1643685 | Disease | 0.398976 | 0.399 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.399374 | 0.399 |
| R-HSA-9634597 | GPER1 signaling | 0.404925 | 0.393 |
| R-HSA-425410 | Metal ion SLC transporters | 0.404925 | 0.393 |
| R-HSA-1474244 | Extracellular matrix organization | 0.408701 | 0.389 |
| R-HSA-9766229 | Degradation of CDH1 | 0.410425 | 0.387 |
| R-HSA-73893 | DNA Damage Bypass | 0.410425 | 0.387 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.410425 | 0.387 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.410425 | 0.387 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.410425 | 0.387 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.415874 | 0.381 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.415874 | 0.381 |
| R-HSA-5663205 | Infectious disease | 0.417252 | 0.380 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.421274 | 0.375 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.421274 | 0.375 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.426624 | 0.370 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.426624 | 0.370 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.426624 | 0.370 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.426624 | 0.370 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.431924 | 0.365 |
| R-HSA-1221632 | Meiotic synapsis | 0.431924 | 0.365 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.431924 | 0.365 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.437176 | 0.359 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.442380 | 0.354 |
| R-HSA-418597 | G alpha (z) signalling events | 0.442380 | 0.354 |
| R-HSA-5578775 | Ion homeostasis | 0.447536 | 0.349 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.447536 | 0.349 |
| R-HSA-177929 | Signaling by EGFR | 0.447536 | 0.349 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.452645 | 0.344 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.452645 | 0.344 |
| R-HSA-69242 | S Phase | 0.455064 | 0.342 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.455064 | 0.342 |
| R-HSA-166520 | Signaling by NTRKs | 0.455064 | 0.342 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.457707 | 0.339 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.457707 | 0.339 |
| R-HSA-421270 | Cell-cell junction organization | 0.459223 | 0.338 |
| R-HSA-191859 | snRNP Assembly | 0.462722 | 0.335 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.462722 | 0.335 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.462722 | 0.335 |
| R-HSA-977443 | GABA receptor activation | 0.467691 | 0.330 |
| R-HSA-351202 | Metabolism of polyamines | 0.467691 | 0.330 |
| R-HSA-379724 | tRNA Aminoacylation | 0.467691 | 0.330 |
| R-HSA-73894 | DNA Repair | 0.468166 | 0.330 |
| R-HSA-69306 | DNA Replication | 0.470327 | 0.328 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.472615 | 0.325 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.472615 | 0.325 |
| R-HSA-112043 | PLC beta mediated events | 0.472615 | 0.325 |
| R-HSA-211976 | Endogenous sterols | 0.472615 | 0.325 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.472615 | 0.325 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.477493 | 0.321 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.482327 | 0.317 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.482327 | 0.317 |
| R-HSA-373755 | Semaphorin interactions | 0.482327 | 0.317 |
| R-HSA-211981 | Xenobiotics | 0.487116 | 0.312 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.487595 | 0.312 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.491264 | 0.309 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.491861 | 0.308 |
| R-HSA-112040 | G-protein mediated events | 0.501221 | 0.300 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.501221 | 0.300 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.514940 | 0.288 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.519429 | 0.284 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.519429 | 0.284 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.519429 | 0.284 |
| R-HSA-72306 | tRNA processing | 0.523103 | 0.281 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.523877 | 0.281 |
| R-HSA-418555 | G alpha (s) signalling events | 0.525931 | 0.279 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.528284 | 0.277 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.528748 | 0.277 |
| R-HSA-9658195 | Leishmania infection | 0.528769 | 0.277 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.528769 | 0.277 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.531003 | 0.275 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.531554 | 0.274 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.531554 | 0.274 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.531554 | 0.274 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.531554 | 0.274 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.531554 | 0.274 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.532651 | 0.274 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.534348 | 0.272 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.536977 | 0.270 |
| R-HSA-8852135 | Protein ubiquitination | 0.536977 | 0.270 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.536977 | 0.270 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.541264 | 0.267 |
| R-HSA-5689603 | UCH proteinases | 0.541264 | 0.267 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.549720 | 0.260 |
| R-HSA-4086400 | PCP/CE pathway | 0.549720 | 0.260 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.549720 | 0.260 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.558020 | 0.253 |
| R-HSA-6806834 | Signaling by MET | 0.558020 | 0.253 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.562113 | 0.250 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.566169 | 0.247 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.570187 | 0.244 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.574168 | 0.241 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.574168 | 0.241 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.578113 | 0.238 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.578113 | 0.238 |
| R-HSA-1500620 | Meiosis | 0.578113 | 0.238 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.580102 | 0.236 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.582689 | 0.235 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.585893 | 0.232 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.592922 | 0.227 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 0.593531 | 0.227 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.597298 | 0.224 |
| R-HSA-597592 | Post-translational protein modification | 0.597433 | 0.224 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.601030 | 0.221 |
| R-HSA-202424 | Downstream TCR signaling | 0.601030 | 0.221 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.602968 | 0.220 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.615616 | 0.211 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.615616 | 0.211 |
| R-HSA-1296071 | Potassium Channels | 0.629673 | 0.201 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.629673 | 0.201 |
| R-HSA-157579 | Telomere Maintenance | 0.633106 | 0.199 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.633106 | 0.199 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.633106 | 0.199 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.644989 | 0.190 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.646527 | 0.189 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.646527 | 0.189 |
| R-HSA-418990 | Adherens junctions interactions | 0.648144 | 0.188 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.649806 | 0.187 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.656272 | 0.183 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.662620 | 0.179 |
| R-HSA-162906 | HIV Infection | 0.668091 | 0.175 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.668851 | 0.175 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.668851 | 0.175 |
| R-HSA-211000 | Gene Silencing by RNA | 0.668851 | 0.175 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.671924 | 0.173 |
| R-HSA-74160 | Gene expression (Transcription) | 0.674172 | 0.171 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.674968 | 0.171 |
| R-HSA-6803157 | Antimicrobial peptides | 0.680973 | 0.167 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.683934 | 0.165 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.689774 | 0.161 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.690562 | 0.161 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.698334 | 0.156 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.703910 | 0.152 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.706659 | 0.151 |
| R-HSA-5693538 | Homology Directed Repair | 0.706659 | 0.151 |
| R-HSA-73886 | Chromosome Maintenance | 0.714756 | 0.146 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.720031 | 0.143 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.720031 | 0.143 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.722631 | 0.141 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.724640 | 0.140 |
| R-HSA-977606 | Regulation of Complement cascade | 0.725208 | 0.140 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.728230 | 0.138 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.730290 | 0.137 |
| R-HSA-1474165 | Reproduction | 0.742591 | 0.129 |
| R-HSA-9717189 | Sensory perception of taste | 0.744984 | 0.128 |
| R-HSA-9843745 | Adipogenesis | 0.744984 | 0.128 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.745702 | 0.127 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.747354 | 0.126 |
| R-HSA-392499 | Metabolism of proteins | 0.748113 | 0.126 |
| R-HSA-6807070 | PTEN Regulation | 0.765546 | 0.116 |
| R-HSA-9664407 | Parasite infection | 0.767726 | 0.115 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.767726 | 0.115 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.767726 | 0.115 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.769887 | 0.114 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.774148 | 0.111 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.774148 | 0.111 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.776249 | 0.110 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.778330 | 0.109 |
| R-HSA-166658 | Complement cascade | 0.780393 | 0.108 |
| R-HSA-9758941 | Gastrulation | 0.788453 | 0.103 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.790422 | 0.102 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.790422 | 0.102 |
| R-HSA-2142753 | Arachidonate metabolism | 0.794305 | 0.100 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.794305 | 0.100 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.796220 | 0.099 |
| R-HSA-9610379 | HCMV Late Events | 0.803703 | 0.095 |
| R-HSA-162587 | HIV Life Cycle | 0.803703 | 0.095 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.809136 | 0.092 |
| R-HSA-500792 | GPCR ligand binding | 0.819507 | 0.086 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.821238 | 0.086 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.828439 | 0.082 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.830364 | 0.081 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.846282 | 0.072 |
| R-HSA-3781865 | Diseases of glycosylation | 0.848971 | 0.071 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.861190 | 0.065 |
| R-HSA-212436 | Generic Transcription Pathway | 0.871163 | 0.060 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.873618 | 0.059 |
| R-HSA-6805567 | Keratinization | 0.878273 | 0.056 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.886014 | 0.053 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.899000 | 0.046 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.899116 | 0.046 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.906424 | 0.043 |
| R-HSA-382551 | Transport of small molecules | 0.907051 | 0.042 |
| R-HSA-8939211 | ESR-mediated signaling | 0.909026 | 0.041 |
| R-HSA-157118 | Signaling by NOTCH | 0.911557 | 0.040 |
| R-HSA-4839726 | Chromatin organization | 0.918737 | 0.037 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.938160 | 0.028 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.978770 | 0.009 |
| R-HSA-8978868 | Fatty acid metabolism | 0.981936 | 0.008 |
| R-HSA-5668914 | Diseases of metabolism | 0.985065 | 0.007 |
| R-HSA-211859 | Biological oxidations | 0.994027 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.995816 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 0.999494 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999935 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.838 | 0.117 | 2 | 0.880 |
MTOR |
0.828 | 0.042 | 1 | 0.860 |
ULK2 |
0.827 | 0.081 | 2 | 0.846 |
GCN2 |
0.826 | 0.009 | 2 | 0.870 |
DSTYK |
0.826 | 0.058 | 2 | 0.904 |
PRPK |
0.824 | 0.052 | -1 | 0.839 |
CLK3 |
0.822 | 0.088 | 1 | 0.862 |
CDC7 |
0.822 | -0.005 | 1 | 0.888 |
IKKB |
0.821 | -0.024 | -2 | 0.712 |
PIM3 |
0.821 | 0.026 | -3 | 0.853 |
PDHK4 |
0.820 | -0.097 | 1 | 0.906 |
PDHK1 |
0.819 | -0.024 | 1 | 0.899 |
PRKD1 |
0.818 | 0.099 | -3 | 0.834 |
NEK6 |
0.818 | 0.064 | -2 | 0.814 |
NLK |
0.818 | 0.033 | 1 | 0.872 |
RAF1 |
0.818 | -0.045 | 1 | 0.903 |
WNK1 |
0.818 | 0.078 | -2 | 0.861 |
TBK1 |
0.818 | -0.013 | 1 | 0.812 |
NDR2 |
0.818 | 0.018 | -3 | 0.875 |
BMPR2 |
0.818 | 0.017 | -2 | 0.813 |
MST4 |
0.817 | 0.087 | 2 | 0.848 |
NEK7 |
0.817 | 0.005 | -3 | 0.892 |
MARK4 |
0.817 | 0.078 | 4 | 0.792 |
CAMK2G |
0.817 | -0.011 | 2 | 0.839 |
PKN3 |
0.817 | 0.045 | -3 | 0.848 |
ULK1 |
0.817 | 0.000 | -3 | 0.854 |
CAMK2D |
0.816 | 0.065 | -3 | 0.867 |
PKCD |
0.816 | 0.080 | 2 | 0.828 |
MLK1 |
0.815 | 0.019 | 2 | 0.858 |
BCKDK |
0.815 | -0.004 | -1 | 0.828 |
RSK2 |
0.815 | 0.037 | -3 | 0.785 |
IKKE |
0.815 | -0.025 | 1 | 0.807 |
CDKL1 |
0.815 | 0.021 | -3 | 0.808 |
MOS |
0.814 | -0.022 | 1 | 0.896 |
CAMK1B |
0.814 | -0.019 | -3 | 0.892 |
P90RSK |
0.814 | 0.037 | -3 | 0.780 |
ATR |
0.814 | -0.021 | 1 | 0.862 |
MAPKAPK3 |
0.814 | 0.041 | -3 | 0.796 |
NEK9 |
0.813 | 0.045 | 2 | 0.864 |
PKN2 |
0.813 | 0.053 | -3 | 0.876 |
SKMLCK |
0.812 | 0.071 | -2 | 0.801 |
NIK |
0.812 | 0.015 | -3 | 0.918 |
IKKA |
0.812 | 0.016 | -2 | 0.703 |
NDR1 |
0.811 | 0.001 | -3 | 0.870 |
ERK5 |
0.811 | 0.029 | 1 | 0.829 |
CDKL5 |
0.810 | 0.034 | -3 | 0.793 |
CHAK2 |
0.810 | 0.021 | -1 | 0.806 |
TGFBR2 |
0.810 | -0.024 | -2 | 0.676 |
LATS2 |
0.810 | 0.018 | -5 | 0.689 |
RSK3 |
0.810 | 0.045 | -3 | 0.776 |
WNK3 |
0.809 | -0.042 | 1 | 0.871 |
DAPK2 |
0.809 | 0.014 | -3 | 0.898 |
AMPKA1 |
0.809 | 0.035 | -3 | 0.886 |
MLK2 |
0.809 | 0.042 | 2 | 0.866 |
NUAK2 |
0.809 | 0.022 | -3 | 0.873 |
RIPK3 |
0.809 | -0.031 | 3 | 0.696 |
GRK5 |
0.809 | -0.070 | -3 | 0.903 |
CAMLCK |
0.808 | -0.002 | -2 | 0.783 |
MAPKAPK2 |
0.808 | 0.047 | -3 | 0.745 |
ICK |
0.808 | 0.031 | -3 | 0.848 |
MNK2 |
0.808 | 0.062 | -2 | 0.744 |
NIM1 |
0.807 | 0.024 | 3 | 0.735 |
GRK1 |
0.807 | 0.020 | -2 | 0.685 |
PRKD2 |
0.807 | 0.032 | -3 | 0.786 |
GRK6 |
0.807 | -0.007 | 1 | 0.916 |
MASTL |
0.807 | -0.065 | -2 | 0.792 |
TSSK1 |
0.807 | 0.055 | -3 | 0.896 |
PIM1 |
0.807 | 0.020 | -3 | 0.803 |
FAM20C |
0.806 | 0.095 | 2 | 0.696 |
SRPK1 |
0.806 | 0.044 | -3 | 0.746 |
TSSK2 |
0.806 | 0.040 | -5 | 0.766 |
DLK |
0.806 | -0.065 | 1 | 0.926 |
CAMK2B |
0.805 | 0.047 | 2 | 0.817 |
PKCB |
0.804 | 0.070 | 2 | 0.775 |
P70S6KB |
0.804 | 0.001 | -3 | 0.822 |
ANKRD3 |
0.804 | -0.015 | 1 | 0.917 |
AMPKA2 |
0.804 | 0.029 | -3 | 0.853 |
MLK4 |
0.804 | 0.042 | 2 | 0.794 |
PKCA |
0.803 | 0.063 | 2 | 0.775 |
PKACG |
0.803 | -0.007 | -2 | 0.676 |
QSK |
0.803 | 0.037 | 4 | 0.771 |
HUNK |
0.802 | -0.074 | 2 | 0.848 |
PKCG |
0.802 | 0.040 | 2 | 0.776 |
RIPK1 |
0.802 | -0.059 | 1 | 0.864 |
MLK3 |
0.802 | 0.015 | 2 | 0.790 |
PAK3 |
0.802 | 0.012 | -2 | 0.724 |
MEK1 |
0.802 | 0.004 | 2 | 0.891 |
HIPK4 |
0.801 | 0.006 | 1 | 0.792 |
RSK4 |
0.801 | 0.033 | -3 | 0.756 |
PKR |
0.801 | 0.067 | 1 | 0.866 |
IRE1 |
0.801 | 0.003 | 1 | 0.809 |
CAMK4 |
0.801 | -0.041 | -3 | 0.869 |
PLK1 |
0.801 | -0.006 | -2 | 0.721 |
PKCH |
0.801 | 0.043 | 2 | 0.784 |
LATS1 |
0.800 | 0.037 | -3 | 0.893 |
YSK4 |
0.800 | -0.001 | 1 | 0.854 |
CDK8 |
0.800 | 0.014 | 1 | 0.697 |
MELK |
0.800 | 0.015 | -3 | 0.837 |
GRK4 |
0.800 | -0.074 | -2 | 0.721 |
PAK1 |
0.800 | 0.009 | -2 | 0.721 |
NEK2 |
0.800 | 0.014 | 2 | 0.844 |
QIK |
0.799 | -0.021 | -3 | 0.880 |
TGFBR1 |
0.799 | 0.021 | -2 | 0.688 |
PHKG1 |
0.799 | 0.013 | -3 | 0.862 |
BMPR1B |
0.799 | 0.051 | 1 | 0.869 |
AURC |
0.799 | 0.019 | -2 | 0.582 |
BRSK2 |
0.799 | 0.018 | -3 | 0.855 |
SMG1 |
0.799 | 0.023 | 1 | 0.797 |
MARK2 |
0.799 | 0.043 | 4 | 0.689 |
VRK2 |
0.799 | 0.068 | 1 | 0.913 |
PAK6 |
0.798 | 0.033 | -2 | 0.657 |
ALK4 |
0.798 | -0.022 | -2 | 0.722 |
CAMK2A |
0.798 | 0.023 | 2 | 0.822 |
MSK2 |
0.798 | -0.020 | -3 | 0.753 |
CDK5 |
0.798 | 0.062 | 1 | 0.708 |
SRPK2 |
0.798 | 0.018 | -3 | 0.672 |
BRSK1 |
0.797 | 0.021 | -3 | 0.823 |
PRKD3 |
0.797 | 0.015 | -3 | 0.767 |
SIK |
0.797 | 0.004 | -3 | 0.802 |
MARK3 |
0.797 | 0.038 | 4 | 0.718 |
CHK1 |
0.797 | 0.027 | -3 | 0.860 |
PKCZ |
0.797 | 0.032 | 2 | 0.819 |
IRE2 |
0.796 | -0.002 | 2 | 0.817 |
NUAK1 |
0.796 | -0.007 | -3 | 0.827 |
SGK3 |
0.796 | 0.044 | -3 | 0.790 |
MSK1 |
0.796 | 0.002 | -3 | 0.758 |
ATM |
0.796 | -0.028 | 1 | 0.797 |
CLK1 |
0.796 | 0.043 | -3 | 0.774 |
CDK19 |
0.796 | 0.020 | 1 | 0.653 |
DRAK1 |
0.795 | 0.023 | 1 | 0.874 |
TTBK2 |
0.795 | -0.103 | 2 | 0.726 |
MNK1 |
0.795 | 0.012 | -2 | 0.733 |
ZAK |
0.795 | 0.031 | 1 | 0.893 |
CLK4 |
0.795 | 0.020 | -3 | 0.794 |
CHAK1 |
0.795 | -0.015 | 2 | 0.813 |
KIS |
0.794 | -0.016 | 1 | 0.721 |
PLK4 |
0.794 | 0.031 | 2 | 0.717 |
ACVR2B |
0.794 | 0.003 | -2 | 0.686 |
ACVR2A |
0.794 | -0.008 | -2 | 0.676 |
BRAF |
0.794 | -0.003 | -4 | 0.446 |
AURB |
0.793 | -0.003 | -2 | 0.585 |
SRPK3 |
0.793 | 0.007 | -3 | 0.724 |
PKG2 |
0.793 | 0.021 | -2 | 0.605 |
GRK7 |
0.793 | 0.002 | 1 | 0.842 |
CDK1 |
0.793 | 0.039 | 1 | 0.657 |
CDK13 |
0.793 | 0.020 | 1 | 0.664 |
DCAMKL1 |
0.792 | 0.049 | -3 | 0.822 |
PKACB |
0.792 | 0.021 | -2 | 0.606 |
JNK3 |
0.792 | 0.038 | 1 | 0.681 |
JNK2 |
0.792 | 0.046 | 1 | 0.649 |
DNAPK |
0.792 | 0.011 | 1 | 0.740 |
AURA |
0.791 | 0.002 | -2 | 0.551 |
WNK4 |
0.791 | 0.032 | -2 | 0.878 |
AKT2 |
0.791 | 0.022 | -3 | 0.703 |
PKCT |
0.791 | 0.044 | 2 | 0.787 |
CDK7 |
0.791 | 0.001 | 1 | 0.695 |
MARK1 |
0.791 | -0.006 | 4 | 0.738 |
ALK2 |
0.791 | -0.018 | -2 | 0.690 |
CDK2 |
0.791 | 0.026 | 1 | 0.755 |
TLK2 |
0.790 | -0.008 | 1 | 0.829 |
PAK2 |
0.790 | -0.044 | -2 | 0.706 |
MST3 |
0.790 | 0.074 | 2 | 0.845 |
MYLK4 |
0.790 | -0.015 | -2 | 0.691 |
MEKK1 |
0.790 | 0.007 | 1 | 0.883 |
MEKK2 |
0.790 | 0.033 | 2 | 0.861 |
DYRK2 |
0.789 | 0.005 | 1 | 0.704 |
CDK18 |
0.789 | 0.044 | 1 | 0.616 |
MEK5 |
0.789 | -0.056 | 2 | 0.878 |
SNRK |
0.788 | -0.065 | 2 | 0.765 |
PERK |
0.788 | -0.040 | -2 | 0.737 |
PLK3 |
0.788 | -0.055 | 2 | 0.809 |
CLK2 |
0.788 | 0.072 | -3 | 0.759 |
P38A |
0.788 | 0.027 | 1 | 0.726 |
PIM2 |
0.788 | 0.009 | -3 | 0.765 |
HRI |
0.788 | -0.061 | -2 | 0.770 |
PHKG2 |
0.788 | 0.009 | -3 | 0.845 |
TAO3 |
0.787 | 0.053 | 1 | 0.876 |
IRAK4 |
0.787 | 0.011 | 1 | 0.826 |
MEKK3 |
0.786 | -0.074 | 1 | 0.887 |
MAPKAPK5 |
0.786 | -0.068 | -3 | 0.727 |
NEK5 |
0.785 | 0.008 | 1 | 0.865 |
BMPR1A |
0.785 | 0.023 | 1 | 0.854 |
P38B |
0.785 | 0.031 | 1 | 0.657 |
PRKX |
0.784 | 0.023 | -3 | 0.715 |
AKT1 |
0.784 | 0.022 | -3 | 0.728 |
CDK3 |
0.784 | 0.066 | 1 | 0.586 |
CDK12 |
0.784 | 0.014 | 1 | 0.641 |
CDK9 |
0.784 | 0.003 | 1 | 0.674 |
PKCI |
0.783 | 0.023 | 2 | 0.789 |
P38G |
0.783 | 0.033 | 1 | 0.570 |
GRK2 |
0.783 | -0.044 | -2 | 0.622 |
DCAMKL2 |
0.783 | 0.007 | -3 | 0.848 |
PRP4 |
0.783 | -0.005 | -3 | 0.754 |
TAO2 |
0.781 | 0.034 | 2 | 0.868 |
CAMKK1 |
0.781 | -0.026 | -2 | 0.732 |
ERK1 |
0.781 | 0.011 | 1 | 0.643 |
SMMLCK |
0.781 | -0.040 | -3 | 0.842 |
PKACA |
0.781 | 0.008 | -2 | 0.556 |
PKCE |
0.780 | 0.040 | 2 | 0.765 |
EEF2K |
0.780 | 0.052 | 3 | 0.842 |
PINK1 |
0.780 | -0.098 | 1 | 0.817 |
SSTK |
0.780 | -0.001 | 4 | 0.758 |
CDK17 |
0.779 | 0.009 | 1 | 0.572 |
HGK |
0.779 | 0.056 | 3 | 0.852 |
NEK11 |
0.778 | -0.053 | 1 | 0.881 |
CAMK1G |
0.778 | -0.062 | -3 | 0.785 |
P70S6K |
0.778 | -0.028 | -3 | 0.727 |
TNIK |
0.778 | 0.086 | 3 | 0.852 |
CK1E |
0.778 | -0.019 | -3 | 0.617 |
MINK |
0.778 | 0.062 | 1 | 0.855 |
MPSK1 |
0.777 | 0.021 | 1 | 0.765 |
PKN1 |
0.777 | 0.015 | -3 | 0.749 |
PAK5 |
0.777 | -0.015 | -2 | 0.600 |
ERK2 |
0.777 | -0.026 | 1 | 0.692 |
DYRK1A |
0.777 | -0.010 | 1 | 0.766 |
GCK |
0.776 | 0.021 | 1 | 0.868 |
CAMKK2 |
0.776 | -0.050 | -2 | 0.732 |
MEKK6 |
0.776 | 0.025 | 1 | 0.871 |
HIPK1 |
0.775 | -0.000 | 1 | 0.722 |
PDK1 |
0.775 | 0.000 | 1 | 0.862 |
MAP3K15 |
0.775 | 0.031 | 1 | 0.868 |
TLK1 |
0.775 | -0.099 | -2 | 0.724 |
MST2 |
0.775 | -0.021 | 1 | 0.876 |
NEK8 |
0.775 | -0.078 | 2 | 0.857 |
VRK1 |
0.774 | 0.076 | 2 | 0.853 |
LKB1 |
0.774 | -0.035 | -3 | 0.877 |
IRAK1 |
0.774 | -0.119 | -1 | 0.766 |
DAPK3 |
0.774 | 0.009 | -3 | 0.830 |
GSK3B |
0.774 | -0.015 | 4 | 0.448 |
GAK |
0.773 | -0.016 | 1 | 0.846 |
ERK7 |
0.773 | 0.033 | 2 | 0.581 |
CDK14 |
0.773 | 0.004 | 1 | 0.663 |
TAK1 |
0.773 | -0.020 | 1 | 0.884 |
P38D |
0.773 | 0.029 | 1 | 0.566 |
HIPK3 |
0.773 | -0.011 | 1 | 0.733 |
CAMK1D |
0.773 | -0.028 | -3 | 0.716 |
PASK |
0.773 | -0.044 | -3 | 0.877 |
CK1G1 |
0.773 | -0.019 | -3 | 0.617 |
NEK4 |
0.772 | -0.026 | 1 | 0.838 |
HPK1 |
0.772 | 0.024 | 1 | 0.850 |
CDK10 |
0.772 | 0.015 | 1 | 0.645 |
TTBK1 |
0.772 | -0.113 | 2 | 0.640 |
PAK4 |
0.772 | -0.017 | -2 | 0.598 |
HIPK2 |
0.771 | 0.006 | 1 | 0.607 |
LOK |
0.770 | -0.004 | -2 | 0.743 |
LRRK2 |
0.770 | -0.021 | 2 | 0.876 |
MEK2 |
0.770 | -0.043 | 2 | 0.864 |
YSK1 |
0.770 | 0.042 | 2 | 0.832 |
NEK1 |
0.770 | 0.013 | 1 | 0.851 |
AKT3 |
0.770 | 0.014 | -3 | 0.628 |
GSK3A |
0.770 | 0.005 | 4 | 0.458 |
DYRK3 |
0.769 | -0.013 | 1 | 0.723 |
KHS2 |
0.769 | 0.065 | 1 | 0.848 |
DYRK4 |
0.769 | 0.007 | 1 | 0.633 |
CHK2 |
0.769 | -0.003 | -3 | 0.653 |
CDK16 |
0.769 | 0.014 | 1 | 0.581 |
KHS1 |
0.769 | 0.056 | 1 | 0.833 |
CDK6 |
0.768 | 0.027 | 1 | 0.638 |
GRK3 |
0.768 | -0.047 | -2 | 0.569 |
NEK3 |
0.768 | 0.037 | 1 | 0.834 |
SGK1 |
0.768 | 0.013 | -3 | 0.614 |
CK1D |
0.767 | -0.032 | -3 | 0.568 |
DAPK1 |
0.767 | -0.010 | -3 | 0.808 |
PDHK3_TYR |
0.767 | 0.130 | 4 | 0.869 |
CK2A2 |
0.767 | 0.006 | 1 | 0.761 |
MRCKB |
0.767 | 0.004 | -3 | 0.768 |
DYRK1B |
0.766 | -0.020 | 1 | 0.659 |
MRCKA |
0.766 | -0.018 | -3 | 0.793 |
RIPK2 |
0.765 | -0.117 | 1 | 0.844 |
SLK |
0.765 | -0.023 | -2 | 0.689 |
CDK4 |
0.765 | 0.019 | 1 | 0.622 |
ROCK2 |
0.765 | 0.015 | -3 | 0.822 |
OSR1 |
0.764 | 0.047 | 2 | 0.850 |
MAK |
0.763 | 0.049 | -2 | 0.691 |
CK1A2 |
0.763 | -0.036 | -3 | 0.565 |
STK33 |
0.763 | -0.079 | 2 | 0.669 |
MST1 |
0.762 | -0.072 | 1 | 0.859 |
JNK1 |
0.761 | -0.005 | 1 | 0.633 |
PBK |
0.761 | -0.006 | 1 | 0.753 |
SBK |
0.761 | -0.005 | -3 | 0.571 |
CAMK1A |
0.760 | -0.030 | -3 | 0.674 |
MOK |
0.759 | 0.017 | 1 | 0.712 |
PLK2 |
0.758 | -0.051 | -3 | 0.837 |
TESK1_TYR |
0.758 | -0.023 | 3 | 0.842 |
CK2A1 |
0.758 | 0.000 | 1 | 0.747 |
PKG1 |
0.757 | -0.018 | -2 | 0.528 |
MAP2K4_TYR |
0.757 | -0.010 | -1 | 0.859 |
PKMYT1_TYR |
0.757 | 0.047 | 3 | 0.803 |
MAP2K7_TYR |
0.757 | -0.042 | 2 | 0.899 |
PDHK4_TYR |
0.756 | -0.012 | 2 | 0.912 |
LIMK2_TYR |
0.756 | 0.065 | -3 | 0.920 |
MAP2K6_TYR |
0.755 | -0.012 | -1 | 0.858 |
EPHA6 |
0.754 | 0.096 | -1 | 0.832 |
DMPK1 |
0.754 | 0.003 | -3 | 0.793 |
BMPR2_TYR |
0.754 | -0.020 | -1 | 0.827 |
PINK1_TYR |
0.754 | -0.070 | 1 | 0.892 |
TAO1 |
0.754 | 0.021 | 1 | 0.808 |
TYRO3 |
0.754 | 0.057 | 3 | 0.773 |
ASK1 |
0.753 | 0.007 | 1 | 0.857 |
MYO3B |
0.753 | 0.027 | 2 | 0.847 |
RET |
0.753 | 0.021 | 1 | 0.875 |
PDHK1_TYR |
0.752 | -0.065 | -1 | 0.862 |
EPHB4 |
0.752 | 0.051 | -1 | 0.835 |
ROCK1 |
0.751 | -0.004 | -3 | 0.786 |
ROS1 |
0.751 | 0.045 | 3 | 0.751 |
TXK |
0.751 | 0.097 | 1 | 0.915 |
TYK2 |
0.751 | -0.002 | 1 | 0.867 |
BUB1 |
0.750 | -0.006 | -5 | 0.728 |
TTK |
0.750 | -0.032 | -2 | 0.718 |
CRIK |
0.749 | 0.001 | -3 | 0.714 |
TNNI3K_TYR |
0.749 | 0.097 | 1 | 0.880 |
MYO3A |
0.749 | -0.008 | 1 | 0.825 |
DDR1 |
0.748 | -0.007 | 4 | 0.789 |
CSF1R |
0.747 | 0.010 | 3 | 0.743 |
MST1R |
0.747 | -0.018 | 3 | 0.763 |
JAK2 |
0.747 | -0.019 | 1 | 0.878 |
LIMK1_TYR |
0.746 | -0.060 | 2 | 0.887 |
PDGFRB |
0.746 | 0.015 | 3 | 0.772 |
STLK3 |
0.746 | -0.029 | 1 | 0.848 |
EPHB1 |
0.745 | 0.016 | 1 | 0.928 |
SRMS |
0.744 | 0.029 | 1 | 0.917 |
AXL |
0.744 | 0.045 | 3 | 0.725 |
JAK3 |
0.744 | -0.018 | 1 | 0.873 |
FGR |
0.744 | -0.019 | 1 | 0.897 |
BIKE |
0.744 | -0.015 | 1 | 0.687 |
ITK |
0.743 | 0.036 | -1 | 0.820 |
ABL2 |
0.743 | 0.022 | -1 | 0.827 |
EPHB3 |
0.743 | 0.025 | -1 | 0.833 |
TNK2 |
0.743 | 0.036 | 3 | 0.715 |
FER |
0.743 | -0.034 | 1 | 0.916 |
HCK |
0.743 | 0.015 | -1 | 0.838 |
YES1 |
0.743 | -0.016 | -1 | 0.858 |
HASPIN |
0.742 | -0.042 | -1 | 0.619 |
MERTK |
0.742 | 0.060 | 3 | 0.713 |
FLT3 |
0.741 | -0.007 | 3 | 0.763 |
BTK |
0.740 | -0.004 | -1 | 0.805 |
ABL1 |
0.740 | 0.022 | -1 | 0.828 |
NEK10_TYR |
0.740 | 0.005 | 1 | 0.739 |
JAK1 |
0.740 | 0.032 | 1 | 0.833 |
TEC |
0.740 | 0.035 | -1 | 0.778 |
INSRR |
0.739 | -0.047 | 3 | 0.711 |
FGFR2 |
0.739 | -0.032 | 3 | 0.742 |
EPHB2 |
0.739 | 0.007 | -1 | 0.819 |
LCK |
0.739 | 0.021 | -1 | 0.830 |
BMX |
0.738 | 0.013 | -1 | 0.728 |
PDGFRA |
0.738 | -0.035 | 3 | 0.776 |
KIT |
0.738 | -0.038 | 3 | 0.743 |
EPHA4 |
0.737 | -0.035 | 2 | 0.801 |
TEK |
0.737 | -0.039 | 3 | 0.704 |
ALPHAK3 |
0.737 | -0.093 | -1 | 0.732 |
BLK |
0.736 | 0.032 | -1 | 0.838 |
FGFR1 |
0.736 | -0.036 | 3 | 0.725 |
EPHA1 |
0.736 | 0.038 | 3 | 0.711 |
TNK1 |
0.736 | -0.015 | 3 | 0.739 |
CK1A |
0.735 | -0.046 | -3 | 0.478 |
EPHA7 |
0.735 | 0.013 | 2 | 0.812 |
YANK3 |
0.735 | -0.057 | 2 | 0.411 |
ALK |
0.734 | -0.013 | 3 | 0.694 |
LTK |
0.733 | -0.005 | 3 | 0.700 |
KDR |
0.733 | -0.052 | 3 | 0.705 |
PTK6 |
0.732 | -0.049 | -1 | 0.757 |
WEE1_TYR |
0.731 | -0.037 | -1 | 0.734 |
PTK2B |
0.731 | 0.030 | -1 | 0.817 |
NTRK1 |
0.731 | -0.078 | -1 | 0.810 |
FRK |
0.731 | -0.010 | -1 | 0.852 |
DDR2 |
0.731 | 0.003 | 3 | 0.699 |
NTRK2 |
0.731 | -0.068 | 3 | 0.710 |
MET |
0.728 | -0.066 | 3 | 0.731 |
FYN |
0.728 | -0.004 | -1 | 0.792 |
EPHA3 |
0.727 | -0.064 | 2 | 0.784 |
INSR |
0.727 | -0.061 | 3 | 0.682 |
LYN |
0.726 | -0.029 | 3 | 0.671 |
NTRK3 |
0.726 | -0.052 | -1 | 0.764 |
FGFR3 |
0.726 | -0.075 | 3 | 0.709 |
ERBB2 |
0.726 | -0.096 | 1 | 0.850 |
FLT1 |
0.725 | -0.094 | -1 | 0.790 |
AAK1 |
0.725 | 0.003 | 1 | 0.567 |
FLT4 |
0.724 | -0.096 | 3 | 0.696 |
EPHA5 |
0.724 | -0.028 | 2 | 0.805 |
EPHA8 |
0.723 | -0.027 | -1 | 0.799 |
MATK |
0.722 | -0.055 | -1 | 0.732 |
CSK |
0.721 | -0.060 | 2 | 0.809 |
SRC |
0.720 | -0.035 | -1 | 0.809 |
EGFR |
0.720 | -0.042 | 1 | 0.777 |
MUSK |
0.715 | -0.041 | 1 | 0.743 |
FGFR4 |
0.714 | -0.068 | -1 | 0.753 |
PTK2 |
0.713 | -0.028 | -1 | 0.726 |
EPHA2 |
0.712 | -0.046 | -1 | 0.753 |
CK1G3 |
0.711 | -0.063 | -3 | 0.430 |
SYK |
0.710 | -0.045 | -1 | 0.717 |
IGF1R |
0.710 | -0.089 | 3 | 0.619 |
FES |
0.706 | -0.031 | -1 | 0.709 |
YANK2 |
0.705 | -0.073 | 2 | 0.438 |
ERBB4 |
0.704 | -0.038 | 1 | 0.773 |
CK1G2 |
0.687 | -0.078 | -3 | 0.531 |
ZAP70 |
0.686 | -0.048 | -1 | 0.648 |