Motif 33 (n=135)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B2RNG4 | TRIM6-TRIM34 | S441 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| E9PAV3 | NACA | S1977 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00203 | AP3B1 | S609 | ochoa | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305|PubMed:9151686}. |
| O14976 | GAK | S326 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15014 | ZNF609 | S433 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15409 | FOXP2 | S591 | ochoa | Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. |
| O43166 | SIPA1L1 | S1734 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43678 | NDUFA2 | S27 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O60488 | ACSL4 | S674 | ochoa | Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). {ECO:0000250|UniProtKB:O35547, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| O60673 | REV3L | S1030 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
| O75152 | ZC3H11A | S108 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75362 | ZNF217 | S570 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75363 | BCAS1 | S399 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75448 | MED24 | S431 | ochoa | Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}. |
| O75665 | OFD1 | S844 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O94967 | WDR47 | S558 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95402 | MED26 | S470 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O95573 | ACSL3 | S683 | ochoa | Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). {ECO:0000250|UniProtKB:Q63151, ECO:0000269|PubMed:18003621, ECO:0000269|PubMed:22633490}. |
| O95671 | ASMTL | S421 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
| O96019 | ACTL6A | S86 | ochoa|psp | Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O96028 | NSD2 | S121 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P05156 | CFI | S24 | ochoa | Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain] | Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed:17320177, PubMed:7360115). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed:12055245, PubMed:2141838, PubMed:9605165). The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed:28671664). {ECO:0000269|PubMed:12055245, ECO:0000269|PubMed:17320177, ECO:0000269|PubMed:2141838, ECO:0000269|PubMed:28671664, ECO:0000269|PubMed:7360115, ECO:0000269|PubMed:9605165}. |
| P07195 | LDHB | S238 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P11940 | PABPC1 | S342 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P17252 | PRKCA | S319 | ochoa | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P21796 | VDAC1 | S240 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P22607 | FGFR3 | S408 | ochoa | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}. |
| P28562 | DUSP1 | S296 | psp | Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250|UniProtKB:P28563}. |
| P29375 | KDM5A | S1438 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P31327 | CPS1 | S1079 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P33981 | TTK | S49 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P41212 | ETV6 | S131 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P41218 | MNDA | S227 | ochoa | Myeloid cell nuclear differentiation antigen | May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1. |
| P45880 | VDAC2 | S251 | ochoa | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P49327 | FASN | S207 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P52272 | HNRNPM | S701 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P53992 | SEC24C | S862 | ochoa | Protein transport protein Sec24C (SEC24-related protein C) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| P54750 | PDE1A | S487 | ochoa | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) | Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. {ECO:0000269|PubMed:8557689}. |
| P55201 | BRPF1 | S238 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P63010 | AP2B1 | S605 | ochoa | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| Q00610 | CLTC | S751 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q04656 | ATP7A | S427 | ochoa | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q05209 | PTPN12 | S468 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q06187 | BTK | S21 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q13310 | PABPC4 | S342 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13330 | MTA1 | S576 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q13416 | ORC2 | S280 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13428 | TCOF1 | S823 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14004 | CDK13 | S664 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14643 | ITPR1 | S436 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000250|UniProtKB:P29994, ECO:0000269|PubMed:10620513, ECO:0000269|PubMed:27108797}. |
| Q14669 | TRIP12 | S1427 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14CS0 | UBXN2B | S235 | ochoa | UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37) | Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000269|PubMed:17141156, ECO:0000269|PubMed:23649807}. |
| Q15349 | RPS6KA2 | S546 | ochoa | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q15464 | SHB | S388 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15468 | STIL | S475 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q2TBE0 | CWF19L2 | S479 | ochoa | CWF19-like protein 2 | None |
| Q3T8J9 | GON4L | S206 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q4VXU2 | PABPC1L | S342 | ochoa | Polyadenylate-binding protein 1-like (Embryonic poly(A)-binding protein) (Poly(A) binding protein cytoplasmic 1 like) | Poly(A)-binding protein involved in oocyte maturation and early embryo development (PubMed:37723834, PubMed:37052235). It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes (By similarity). {ECO:0000250|UniProtKB:A2A5N3, ECO:0000269|PubMed:37052235, ECO:0000269|PubMed:37723834}. |
| Q567U6 | CCDC93 | S305 | ochoa | Coiled-coil domain-containing protein 93 | Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}. |
| Q5FBB7 | SGO1 | S256 | ochoa | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5SY16 | NOL9 | S249 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T0T0 | MARCHF8 | S253 | ochoa | E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8) | E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:34285233, PubMed:35019698, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:19117940, PubMed:19566897). Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins (PubMed:32934085). Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation (PubMed:35019698). Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses (PubMed:34285233, PubMed:35019698). Strongly blocks human immunodeficiency virus type 1 envelope glycoprotein incorporation into virions by down-regulating its cell surface expression. Also blocks ebola virus glycoprotein/GP incorporation via surface down-regulation (PubMed:32934085). Mediates 'Lys-63'-linked polyubiquitination of influenza M2 to target it to lysosome for degradation (PubMed:34285233). Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway (PubMed:28320822). Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination (PubMed:34183449). Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863). Negatively regulates IL7-mediated T-cell homeostasis by mediating 'Lys-27'-linked polyubiquitination of IL7R, leading to its lysosomal degradation (PubMed:39311660). {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:19566897, ECO:0000269|PubMed:28320822, ECO:0000269|PubMed:32934085, ECO:0000269|PubMed:34183449, ECO:0000269|PubMed:34285233, ECO:0000269|PubMed:35019698, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:39311660}.; FUNCTION: (Microbial infection) Mediates 'Lys-63'-linked polyubiquitination of hepatitis C virus/HCV protein NS2 which allows its binding to HGS, an ESCRT-0 complex component, and this interaction is essential for HCV envelopment. {ECO:0000269|PubMed:30759391}. |
| Q5T0W9 | FAM83B | S764 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T1R4 | HIVEP3 | S682 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5VUA4 | ZNF318 | S2243 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q659A1 | ICE2 | S326 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q676U5 | ATG16L1 | S331 | ochoa | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q6KC79 | NIPBL | S2568 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P3S1 | DENND1B | S690 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6ZSZ6 | TSHZ1 | S830 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q709C8 | VPS13C | S2071 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q7Z2Z1 | TICRR | S1001 | ochoa|psp | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q86UR5 | RIMS1 | S1613 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86XP1 | DGKH | S1075 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q8IVF2 | AHNAK2 | S2179 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S5741 | ochoa | Protein AHNAK2 | None |
| Q8IX90 | SKA3 | T203 | psp | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8IXS8 | HYCC2 | S398 | ochoa | Hyccin 2 | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}. |
| Q8IYB7 | DIS3L2 | S503 | ochoa | DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}. |
| Q8IYM9 | TRIM22 | S87 | ochoa | E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22) | Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed:25683609, PubMed:35777501). Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed:25683609, PubMed:35777501, PubMed:36042495). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed:25683609). Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed:36042495). Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed:26683615). Also plays a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed:36159777). Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed:35777501). {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19218198, ECO:0000269|PubMed:19585648, ECO:0000269|PubMed:25683609, ECO:0000269|PubMed:26683615, ECO:0000269|PubMed:35777501, ECO:0000269|PubMed:36042495, ECO:0000269|PubMed:36159777}. |
| Q8N554 | ZNF276 | S160 | ochoa | Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) | May be involved in transcriptional regulation. |
| Q8NDI1 | EHBP1 | S964 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFU7 | TET1 | S322 | ochoa | Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) | Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093, ECO:0000269|PubMed:35798741}.; FUNCTION: [Isoform 1]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.; FUNCTION: [Isoform 2]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}. |
| Q8TAD7 | OCC1 | S28 | ochoa | Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3) | None |
| Q8TCC3 | MRPL30 | S49 | ochoa | Large ribosomal subunit protein uL30m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (39S ribosomal protein L30, mitochondrial) (L30mt) (MRP-L30) | None |
| Q8WVM7 | STAG1 | S756 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WVV9 | HNRNPLL | S75 | ochoa | Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
| Q92622 | RUBCN | S266 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q92817 | EVPL | S1263 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
| Q96BP3 | PPWD1 | S289 | ochoa | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:20676357}. |
| Q96BY7 | ATG2B | S735 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96ED9 | HOOK2 | S163 | ochoa | Protein Hook homolog 2 (h-hook2) (hHK2) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q96FJ0 | STAMBPL1 | S25 | ochoa | AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). {ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100}. |
| Q96JB2 | COG3 | S212 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96KC8 | DNAJC1 | S381 | ochoa | DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) | May modulate protein synthesis. {ECO:0000250}. |
| Q96L73 | NSD1 | S822 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96PY6 | NEK1 | S1008 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96R06 | SPAG5 | S115 | psp | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96T58 | SPEN | S1222 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q9BY89 | KIAA1671 | S749 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYJ4 | TRIM34 | S87 | ochoa | E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21) | Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853). During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966). In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709). Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507). {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:31487507, ECO:0000269|PubMed:31956709, ECO:0000269|PubMed:32282853, ECO:0000269|PubMed:35065966}. |
| Q9BZK3 | NACA4P | S113 | ochoa | Putative nascent polypeptide-associated complex subunit alpha-like protein (Alpha-NAC pseudogene 1) (NAC-alpha pseudogene 1) (NACA family member 4, pseudogene) | None |
| Q9C035 | TRIM5 | S86 | ochoa | Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5) | Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057). {ECO:0000269|PubMed:12878161, ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:18312418, ECO:0000269|PubMed:21035162, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:21632761, ECO:0000269|PubMed:22291694, ECO:0000269|PubMed:25127057}. |
| Q9H116 | GZF1 | S613 | ochoa | GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) | Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}. |
| Q9H2U1 | DHX36 | S963 | ochoa | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9H2Y7 | ZNF106 | S893 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H361 | PABPC3 | S342 | ochoa | Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. |
| Q9H4I2 | ZHX3 | S577 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H582 | ZNF644 | S1214 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9HCM4 | EPB41L5 | S550 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9NP74 | PALMD | S489 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NYV6 | RRN3 | S44 | ochoa|psp | RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) | Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}. |
| Q9P2D1 | CHD7 | S1874 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2K5 | MYEF2 | S571 | ochoa | Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156) | Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}. |
| Q9UFC0 | LRWD1 | S212 | ochoa | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:20932478, ECO:0000269|PubMed:21029866, ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22645314}. |
| Q9UHL9 | GTF2IRD1 | S448 | ochoa | General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}. |
| Q9UIG0 | BAZ1B | S361 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9ULD9 | ZNF608 | S1402 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULJ3 | ZBTB21 | S605 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULJ3 | ZBTB21 | S714 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UM63 | PLAGL1 | S229 | ochoa | Zinc finger protein PLAGL1 (Lost on transformation 1) (LOT-1) (Pleiomorphic adenoma-like protein 1) (Tumor suppressor ZAC) | Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. {ECO:0000269|PubMed:18299245, ECO:0000269|PubMed:9722527}. |
| Q9UNX4 | WDR3 | S373 | ochoa | WD repeat-containing protein 3 | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q9Y2L1 | DIS3 | S634 | ochoa | Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20531386}. |
| Q9Y3D7 | PAM16 | S69 | ochoa | Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16) | Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. {ECO:0000269|PubMed:20053669}. |
| Q9Y5A7 | NUB1 | S489 | ochoa | NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}. |
| Q9Y6A5 | TACC3 | S25 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| O14733 | MAP2K7 | S89 | Sugiyama | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| P49753 | ACOT2 | S360 | Sugiyama | Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128) | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10944470, PubMed:16940157). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:10944470, PubMed:16940157). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). {ECO:0000250|UniProtKB:Q9QYR9, ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157}. |
| Q16595 | FXN | S158 | Sugiyama | Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN); Extramitochondrial frataxin] | [Frataxin mature form]: Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly (PubMed:12785837, PubMed:24971490). Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release (PubMed:24971490). Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (PubMed:29576242). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity (PubMed:15641778). May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems (PubMed:11823441, PubMed:12755598). May function as an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation (PubMed:15247478). May play a role as a high affinity iron binding partner for FECH that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis (PubMed:15123683, PubMed:16239244). {ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:11823441, ECO:0000269|PubMed:12755598, ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15123683, ECO:0000269|PubMed:15247478, ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242}.; FUNCTION: [Extramitochondrial frataxin]: Modulates the RNA-binding activity of ACO1 (PubMed:20053667). May be involved in the cytoplasmic iron-sulfur protein biogenesis (PubMed:16091420). May contribute to oxidative stress resistance and overall cell survival (PubMed:16608849). {ECO:0000269|PubMed:16091420, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}. |
| Q86TX2 | ACOT1 | S298 | Sugiyama | Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.-) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2) | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). {ECO:0000269|PubMed:16940157}. |
| P07814 | EPRS1 | S1350 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| Q6PHR2 | ULK3 | S339 | Sugiyama | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}. |
| P15121 | AKR1B1 | S264 | Sugiyama | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:1936586, ECO:0000269|PubMed:21329684, ECO:0000269|PubMed:8343525}. |
| Q6UB35 | MTHFD1L | S366 | Sugiyama | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}. |
| Q9C0D5 | TANC1 | S1830 | Sugiyama | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2033514 | FGFR3 mutant receptor activation | 0.000578 | 3.238 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 0.000578 | 3.238 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.000922 | 3.035 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.004054 | 2.392 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.003791 | 2.421 |
| R-HSA-434313 | Intracellular metabolism of fatty acids regulates insulin secretion | 0.003304 | 2.481 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.002395 | 2.621 |
| R-HSA-163685 | Integration of energy metabolism | 0.003291 | 2.483 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.002162 | 2.665 |
| R-HSA-2033515 | t(4;14) translocations of FGFR3 | 0.027561 | 1.560 |
| R-HSA-8853334 | Signaling by FGFR3 fusions in cancer | 0.027561 | 1.560 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.063138 | 1.200 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.010008 | 2.000 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.071829 | 1.144 |
| R-HSA-111957 | Cam-PDE 1 activation | 0.071829 | 1.144 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.012514 | 1.903 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.012514 | 1.903 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.080439 | 1.095 |
| R-HSA-190371 | FGFR3b ligand binding and activation | 0.088970 | 1.051 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.088970 | 1.051 |
| R-HSA-444257 | RSK activation | 0.097422 | 1.011 |
| R-HSA-196025 | Formation of annular gap junctions | 0.097422 | 1.011 |
| R-HSA-190873 | Gap junction degradation | 0.105797 | 0.976 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.105797 | 0.976 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.024880 | 1.604 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.114094 | 0.943 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.026670 | 1.574 |
| R-HSA-429947 | Deadenylation of mRNA | 0.032339 | 1.490 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.162296 | 0.790 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.170072 | 0.769 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.170072 | 0.769 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.177777 | 0.750 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.207891 | 0.682 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.215247 | 0.667 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.222535 | 0.653 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.132763 | 0.877 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.042720 | 1.369 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.021456 | 1.668 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.258456 | 0.588 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.285174 | 0.545 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.040555 | 1.392 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.229756 | 0.639 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.304919 | 0.516 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.168141 | 0.774 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.088046 | 1.055 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 0.013859 | 1.858 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.019824 | 1.703 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.215247 | 0.667 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.190448 | 0.720 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.257979 | 0.588 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.063138 | 1.200 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.088970 | 1.051 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.114094 | 0.943 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.162296 | 0.790 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.010546 | 1.977 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.019844 | 1.702 |
| R-HSA-1268020 | Mitochondrial protein import | 0.028244 | 1.549 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.129639 | 0.887 |
| R-HSA-9930044 | Nuclear RNA decay | 0.304919 | 0.516 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.263025 | 0.580 |
| R-HSA-5205647 | Mitophagy | 0.056564 | 1.247 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.006728 | 2.172 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.008849 | 2.053 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.010008 | 2.000 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.071829 | 1.144 |
| R-HSA-418457 | cGMP effects | 0.012514 | 1.903 |
| R-HSA-5652227 | Fructose biosynthesis | 0.097422 | 1.011 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 0.114094 | 0.943 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.034324 | 1.464 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.146525 | 0.834 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.044927 | 1.347 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 0.154447 | 0.811 |
| R-HSA-437239 | Recycling pathway of L1 | 0.015140 | 1.820 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.047175 | 1.326 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.061483 | 1.211 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.025264 | 1.597 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.192974 | 0.715 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.079758 | 1.098 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.252713 | 0.597 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.304314 | 0.517 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.303771 | 0.517 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.155082 | 0.809 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.304919 | 0.516 |
| R-HSA-9843745 | Adipogenesis | 0.158442 | 0.800 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.021456 | 1.668 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.097422 | 1.011 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.006951 | 2.158 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.185410 | 0.732 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.229756 | 0.639 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.184713 | 0.734 |
| R-HSA-2424491 | DAP12 signaling | 0.285174 | 0.545 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.040041 | 1.397 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.249278 | 0.603 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.216950 | 0.664 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.114094 | 0.943 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.154447 | 0.811 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.054160 | 1.266 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.192974 | 0.715 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.200467 | 0.698 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.207891 | 0.682 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.215247 | 0.667 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.243998 | 0.613 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.291817 | 0.535 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.120169 | 0.920 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.236910 | 0.625 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.251021 | 0.600 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.251021 | 0.600 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.252713 | 0.597 |
| R-HSA-194138 | Signaling by VEGF | 0.143129 | 0.844 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.042720 | 1.369 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.177777 | 0.750 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.304919 | 0.516 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.191408 | 0.718 |
| R-HSA-416476 | G alpha (q) signalling events | 0.127330 | 0.895 |
| R-HSA-199991 | Membrane Trafficking | 0.286128 | 0.543 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.290516 | 0.537 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.011230 | 1.950 |
| R-HSA-199920 | CREB phosphorylation | 0.080439 | 1.095 |
| R-HSA-70635 | Urea cycle | 0.036356 | 1.439 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.162296 | 0.790 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.200467 | 0.698 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.257979 | 0.588 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.128351 | 0.892 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.128351 | 0.892 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.134615 | 0.871 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.134615 | 0.871 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.039458 | 1.404 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.074378 | 1.129 |
| R-HSA-190236 | Signaling by FGFR | 0.082518 | 1.083 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.051793 | 1.286 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.304919 | 0.516 |
| R-HSA-8953854 | Metabolism of RNA | 0.175980 | 0.755 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.040555 | 1.392 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.013730 | 1.862 |
| R-HSA-9663891 | Selective autophagy | 0.228712 | 0.641 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.041935 | 1.377 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.108299 | 0.965 |
| R-HSA-9609507 | Protein localization | 0.076803 | 1.115 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.154447 | 0.811 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.162296 | 0.790 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.170072 | 0.769 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.185410 | 0.732 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.037059 | 1.431 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.285174 | 0.545 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.304919 | 0.516 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.304919 | 0.516 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.009552 | 2.020 |
| R-HSA-4839726 | Chromatin organization | 0.040998 | 1.387 |
| R-HSA-112043 | PLC beta mediated events | 0.027231 | 1.565 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.283649 | 0.547 |
| R-HSA-111933 | Calmodulin induced events | 0.061483 | 1.211 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.202258 | 0.694 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.154447 | 0.811 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.162296 | 0.790 |
| R-HSA-70370 | Galactose catabolism | 0.177777 | 0.750 |
| R-HSA-111997 | CaM pathway | 0.061483 | 1.211 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 0.082493 | 1.084 |
| R-HSA-4086400 | PCP/CE pathway | 0.047117 | 1.327 |
| R-HSA-109704 | PI3K Cascade | 0.102391 | 0.990 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.257979 | 0.588 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.032455 | 1.489 |
| R-HSA-69275 | G2/M Transition | 0.298706 | 0.525 |
| R-HSA-422356 | Regulation of insulin secretion | 0.019518 | 1.710 |
| R-HSA-1632852 | Macroautophagy | 0.183451 | 0.736 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.303771 | 0.517 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.007756 | 2.110 |
| R-HSA-8964038 | LDL clearance | 0.028510 | 1.545 |
| R-HSA-111996 | Ca-dependent events | 0.079758 | 1.098 |
| R-HSA-112040 | G-protein mediated events | 0.033606 | 1.474 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.105797 | 0.976 |
| R-HSA-198753 | ERK/MAPK targets | 0.215247 | 0.667 |
| R-HSA-5652084 | Fructose metabolism | 0.229756 | 0.639 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.271703 | 0.566 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.069122 | 1.160 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.055735 | 1.254 |
| R-HSA-3214847 | HATs acetylate histones | 0.273340 | 0.563 |
| R-HSA-373760 | L1CAM interactions | 0.122196 | 0.913 |
| R-HSA-70268 | Pyruvate metabolism | 0.061371 | 1.212 |
| R-HSA-9612973 | Autophagy | 0.221495 | 0.655 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.307351 | 0.512 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.030400 | 1.517 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.138530 | 0.858 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.154447 | 0.811 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.207891 | 0.682 |
| R-HSA-450294 | MAP kinase activation | 0.135905 | 0.867 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.278470 | 0.555 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.278470 | 0.555 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.215069 | 0.667 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.247566 | 0.606 |
| R-HSA-3214842 | HDMs demethylate histones | 0.251021 | 0.600 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.145426 | 0.837 |
| R-HSA-448424 | Interleukin-17 signaling | 0.164858 | 0.783 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.093708 | 1.028 |
| R-HSA-112399 | IRS-mediated signalling | 0.123444 | 0.909 |
| R-HSA-4086398 | Ca2+ pathway | 0.174739 | 0.758 |
| R-HSA-112316 | Neuronal System | 0.305299 | 0.515 |
| R-HSA-111885 | Opioid Signalling | 0.093202 | 1.031 |
| R-HSA-9865881 | Complex III assembly | 0.243998 | 0.613 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.234249 | 0.630 |
| R-HSA-418346 | Platelet homeostasis | 0.300801 | 0.522 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.035707 | 1.447 |
| R-HSA-877300 | Interferon gamma signaling | 0.006589 | 2.181 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.132763 | 0.877 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.222535 | 0.653 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.229756 | 0.639 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.135905 | 0.867 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.207030 | 0.684 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.123628 | 0.908 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.048460 | 1.315 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.114094 | 0.943 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.044927 | 1.347 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.023378 | 1.631 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.229756 | 0.639 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.285174 | 0.545 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.229756 | 0.639 |
| R-HSA-3000170 | Syndecan interactions | 0.236910 | 0.625 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.307644 | 0.512 |
| R-HSA-177929 | Signaling by EGFR | 0.120374 | 0.919 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.145426 | 0.837 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.245844 | 0.609 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.051793 | 1.286 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.269902 | 0.569 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.269902 | 0.569 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.269902 | 0.569 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.164858 | 0.783 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.148631 | 0.828 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.297375 | 0.527 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.185410 | 0.732 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.149630 | 0.825 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.142237 | 0.847 |
| R-HSA-182971 | EGFR downregulation | 0.291817 | 0.535 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.256150 | 0.592 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.145426 | 0.837 |
| R-HSA-5688426 | Deubiquitination | 0.115484 | 0.937 |
| R-HSA-9833110 | RSV-host interactions | 0.293946 | 0.532 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.188056 | 0.726 |
| R-HSA-166520 | Signaling by NTRKs | 0.202258 | 0.694 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.245844 | 0.609 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.265954 | 0.575 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.245844 | 0.609 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.285174 | 0.545 |
| R-HSA-913531 | Interferon Signaling | 0.176736 | 0.753 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.311061 | 0.507 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.311376 | 0.507 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.311379 | 0.507 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.311379 | 0.507 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.314475 | 0.502 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.314475 | 0.502 |
| R-HSA-68877 | Mitotic Prometaphase | 0.316450 | 0.500 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.317780 | 0.498 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.318988 | 0.496 |
| R-HSA-68886 | M Phase | 0.322600 | 0.491 |
| R-HSA-381042 | PERK regulates gene expression | 0.324122 | 0.489 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.324693 | 0.489 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.330405 | 0.481 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.330405 | 0.481 |
| R-HSA-8853659 | RET signaling | 0.330405 | 0.481 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.334873 | 0.475 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.336630 | 0.473 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.338257 | 0.471 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.341829 | 0.466 |
| R-HSA-195721 | Signaling by WNT | 0.344203 | 0.463 |
| R-HSA-72172 | mRNA Splicing | 0.346901 | 0.460 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.348377 | 0.458 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.354962 | 0.450 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.354962 | 0.450 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.354962 | 0.450 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.354962 | 0.450 |
| R-HSA-5260271 | Diseases of Immune System | 0.354962 | 0.450 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.354962 | 0.450 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.354962 | 0.450 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.358445 | 0.446 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.360961 | 0.443 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.360961 | 0.443 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.365127 | 0.438 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.366904 | 0.435 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.366904 | 0.435 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.367146 | 0.435 |
| R-HSA-8978868 | Fatty acid metabolism | 0.368544 | 0.434 |
| R-HSA-1640170 | Cell Cycle | 0.369371 | 0.433 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.372792 | 0.429 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.372792 | 0.429 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.378625 | 0.422 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.378625 | 0.422 |
| R-HSA-69481 | G2/M Checkpoints | 0.381713 | 0.418 |
| R-HSA-190828 | Gap junction trafficking | 0.384405 | 0.415 |
| R-HSA-2172127 | DAP12 interactions | 0.384405 | 0.415 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.384405 | 0.415 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.390131 | 0.409 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.391578 | 0.407 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.395804 | 0.403 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.395804 | 0.403 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.396842 | 0.401 |
| R-HSA-8957322 | Metabolism of steroids | 0.398939 | 0.399 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.401425 | 0.396 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.406994 | 0.390 |
| R-HSA-73893 | DNA Damage Bypass | 0.412512 | 0.385 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.412512 | 0.385 |
| R-HSA-72312 | rRNA processing | 0.417207 | 0.380 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.417531 | 0.379 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.420736 | 0.376 |
| R-HSA-2514856 | The phototransduction cascade | 0.423394 | 0.373 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.423933 | 0.373 |
| R-HSA-72187 | mRNA 3'-end processing | 0.428760 | 0.368 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.428760 | 0.368 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.428760 | 0.368 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.428760 | 0.368 |
| R-HSA-1221632 | Meiotic synapsis | 0.434076 | 0.362 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.434076 | 0.362 |
| R-HSA-72649 | Translation initiation complex formation | 0.439343 | 0.357 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.444562 | 0.352 |
| R-HSA-418597 | G alpha (z) signalling events | 0.444562 | 0.352 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.444562 | 0.352 |
| R-HSA-5578775 | Ion homeostasis | 0.449732 | 0.347 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.449732 | 0.347 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.454855 | 0.342 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.455388 | 0.342 |
| R-HSA-69242 | S Phase | 0.458480 | 0.339 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.459930 | 0.337 |
| R-HSA-9033241 | Peroxisomal protein import | 0.464958 | 0.333 |
| R-HSA-379724 | tRNA Aminoacylation | 0.469939 | 0.328 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.469939 | 0.328 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.469939 | 0.328 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.470747 | 0.327 |
| R-HSA-73894 | DNA Repair | 0.473293 | 0.325 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.473788 | 0.324 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.474559 | 0.324 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.474875 | 0.323 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.474875 | 0.323 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.479352 | 0.319 |
| R-HSA-186797 | Signaling by PDGF | 0.479765 | 0.319 |
| R-HSA-1989781 | PPARA activates gene expression | 0.479838 | 0.319 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.480243 | 0.319 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.484609 | 0.315 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.484609 | 0.315 |
| R-HSA-6799198 | Complex I biogenesis | 0.484609 | 0.315 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.484609 | 0.315 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.485846 | 0.314 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.488834 | 0.311 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.494164 | 0.306 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.498876 | 0.302 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.498876 | 0.302 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.503544 | 0.298 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.506534 | 0.295 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.510381 | 0.292 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.517289 | 0.286 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.517289 | 0.286 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.517289 | 0.286 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.517439 | 0.286 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.521787 | 0.283 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.521787 | 0.283 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.526243 | 0.279 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.530657 | 0.275 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.530657 | 0.275 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.530657 | 0.275 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.535031 | 0.272 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.535031 | 0.272 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.535143 | 0.272 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.535143 | 0.272 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.537941 | 0.269 |
| R-HSA-380287 | Centrosome maturation | 0.539364 | 0.268 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.539364 | 0.268 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.539364 | 0.268 |
| R-HSA-5689603 | UCH proteinases | 0.543657 | 0.265 |
| R-HSA-611105 | Respiratory electron transport | 0.549019 | 0.260 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.550993 | 0.259 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.552124 | 0.258 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.552124 | 0.258 |
| R-HSA-2559583 | Cellular Senescence | 0.554489 | 0.256 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.556299 | 0.255 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.560436 | 0.251 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.564029 | 0.249 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.564534 | 0.248 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.566180 | 0.247 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.568594 | 0.245 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.568594 | 0.245 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.572028 | 0.243 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.576601 | 0.239 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.576601 | 0.239 |
| R-HSA-983712 | Ion channel transport | 0.578522 | 0.238 |
| R-HSA-1500620 | Meiosis | 0.580549 | 0.236 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.580549 | 0.236 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.584461 | 0.233 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.584461 | 0.233 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.584461 | 0.233 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.588336 | 0.230 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.592176 | 0.228 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.595980 | 0.225 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.596555 | 0.224 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.599749 | 0.222 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.603482 | 0.219 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.603482 | 0.219 |
| R-HSA-422475 | Axon guidance | 0.609690 | 0.215 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.610846 | 0.214 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.611551 | 0.214 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.614009 | 0.212 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.618075 | 0.209 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.632133 | 0.199 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.632133 | 0.199 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.632133 | 0.199 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.635567 | 0.197 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.638969 | 0.195 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.640269 | 0.194 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.645678 | 0.190 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.645678 | 0.190 |
| R-HSA-68882 | Mitotic Anaphase | 0.647185 | 0.189 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.649467 | 0.187 |
| R-HSA-418990 | Adherens junctions interactions | 0.651737 | 0.186 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.652263 | 0.186 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.652263 | 0.186 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.655510 | 0.183 |
| R-HSA-8951664 | Neddylation | 0.658478 | 0.181 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.665071 | 0.177 |
| R-HSA-9675108 | Nervous system development | 0.665074 | 0.177 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.666968 | 0.176 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.671298 | 0.173 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.671298 | 0.173 |
| R-HSA-69239 | Synthesis of DNA | 0.671298 | 0.173 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.674369 | 0.171 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.674369 | 0.171 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.677411 | 0.169 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.677411 | 0.169 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.677411 | 0.169 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.678080 | 0.169 |
| R-HSA-6803157 | Antimicrobial peptides | 0.683410 | 0.165 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.686368 | 0.163 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.686368 | 0.163 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.686368 | 0.163 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.692202 | 0.160 |
| R-HSA-8939211 | ESR-mediated signaling | 0.692690 | 0.159 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.700751 | 0.154 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.703548 | 0.153 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.703548 | 0.153 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.706319 | 0.151 |
| R-HSA-5693538 | Homology Directed Repair | 0.709064 | 0.149 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.711784 | 0.148 |
| R-HSA-68875 | Mitotic Prophase | 0.714478 | 0.146 |
| R-HSA-421270 | Cell-cell junction organization | 0.720281 | 0.142 |
| R-HSA-162582 | Signal Transduction | 0.722621 | 0.141 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.725008 | 0.140 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.725008 | 0.140 |
| R-HSA-977606 | Regulation of Complement cascade | 0.727580 | 0.138 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.728797 | 0.137 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.730128 | 0.137 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.730128 | 0.137 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.730128 | 0.137 |
| R-HSA-69206 | G1/S Transition | 0.730128 | 0.137 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.732652 | 0.135 |
| R-HSA-1474165 | Reproduction | 0.744925 | 0.128 |
| R-HSA-5576891 | Cardiac conduction | 0.747312 | 0.126 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.752019 | 0.124 |
| R-HSA-1266738 | Developmental Biology | 0.754888 | 0.122 |
| R-HSA-388396 | GPCR downstream signalling | 0.754923 | 0.122 |
| R-HSA-418594 | G alpha (i) signalling events | 0.763900 | 0.117 |
| R-HSA-5368287 | Mitochondrial translation | 0.765623 | 0.116 |
| R-HSA-446728 | Cell junction organization | 0.767645 | 0.115 |
| R-HSA-6807070 | PTEN Regulation | 0.767817 | 0.115 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.767817 | 0.115 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.769991 | 0.114 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.769991 | 0.114 |
| R-HSA-9664407 | Parasite infection | 0.769991 | 0.114 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.772144 | 0.112 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.772456 | 0.112 |
| R-HSA-9658195 | Leishmania infection | 0.772456 | 0.112 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.776392 | 0.110 |
| R-HSA-166658 | Complement cascade | 0.782615 | 0.106 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.784652 | 0.105 |
| R-HSA-2187338 | Visual phototransduction | 0.786669 | 0.104 |
| R-HSA-9679506 | SARS-CoV Infections | 0.787752 | 0.104 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.792608 | 0.101 |
| R-HSA-72766 | Translation | 0.792783 | 0.101 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.796477 | 0.099 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.796477 | 0.099 |
| R-HSA-69306 | DNA Replication | 0.798384 | 0.098 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.800273 | 0.097 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.811246 | 0.091 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.811246 | 0.091 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.818226 | 0.087 |
| R-HSA-1500931 | Cell-Cell communication | 0.822486 | 0.085 |
| R-HSA-72306 | tRNA processing | 0.829830 | 0.081 |
| R-HSA-382551 | Transport of small molecules | 0.830575 | 0.081 |
| R-HSA-418555 | G alpha (s) signalling events | 0.831426 | 0.080 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.831426 | 0.080 |
| R-HSA-372790 | Signaling by GPCR | 0.832152 | 0.080 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.834575 | 0.079 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.834575 | 0.079 |
| R-HSA-168256 | Immune System | 0.834846 | 0.078 |
| R-HSA-74160 | Gene expression (Transcription) | 0.842088 | 0.075 |
| R-HSA-168255 | Influenza Infection | 0.843674 | 0.074 |
| R-HSA-449147 | Signaling by Interleukins | 0.855772 | 0.068 |
| R-HSA-5617833 | Cilium Assembly | 0.859083 | 0.066 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.871778 | 0.060 |
| R-HSA-1280218 | Adaptive Immune System | 0.874576 | 0.058 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.875115 | 0.058 |
| R-HSA-6805567 | Keratinization | 0.879982 | 0.056 |
| R-HSA-397014 | Muscle contraction | 0.886597 | 0.052 |
| R-HSA-168249 | Innate Immune System | 0.889702 | 0.051 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.900658 | 0.045 |
| R-HSA-162906 | HIV Infection | 0.901593 | 0.045 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.902519 | 0.045 |
| R-HSA-556833 | Metabolism of lipids | 0.904487 | 0.044 |
| R-HSA-157118 | Signaling by NOTCH | 0.912985 | 0.040 |
| R-HSA-9824446 | Viral Infection Pathways | 0.915871 | 0.038 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.920136 | 0.036 |
| R-HSA-597592 | Post-translational protein modification | 0.921487 | 0.036 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.930023 | 0.032 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.932862 | 0.030 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.933264 | 0.030 |
| R-HSA-6798695 | Neutrophil degranulation | 0.939144 | 0.027 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.939484 | 0.027 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.941566 | 0.026 |
| R-HSA-109582 | Hemostasis | 0.945177 | 0.024 |
| R-HSA-392499 | Metabolism of proteins | 0.953612 | 0.021 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.959280 | 0.018 |
| R-HSA-212436 | Generic Transcription Pathway | 0.962582 | 0.017 |
| R-HSA-1474244 | Extracellular matrix organization | 0.963328 | 0.016 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.969108 | 0.014 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.979312 | 0.009 |
| R-HSA-5663205 | Infectious disease | 0.982394 | 0.008 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.988900 | 0.005 |
| R-HSA-2262752 | Cellular responses to stress | 0.988911 | 0.005 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.995647 | 0.002 |
| R-HSA-1643685 | Disease | 0.997063 | 0.001 |
| R-HSA-1430728 | Metabolism | 0.998470 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999995 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK8 |
0.828 | 0.737 | 1 | 0.839 |
CDK19 |
0.825 | 0.722 | 1 | 0.869 |
CDK17 |
0.825 | 0.760 | 1 | 0.895 |
JNK2 |
0.825 | 0.795 | 1 | 0.871 |
P38G |
0.824 | 0.781 | 1 | 0.904 |
CDK18 |
0.822 | 0.733 | 1 | 0.872 |
P38D |
0.822 | 0.771 | 1 | 0.907 |
KIS |
0.821 | 0.652 | 1 | 0.815 |
CDK3 |
0.820 | 0.675 | 1 | 0.892 |
P38B |
0.818 | 0.752 | 1 | 0.841 |
CDK7 |
0.818 | 0.716 | 1 | 0.837 |
CDK16 |
0.818 | 0.729 | 1 | 0.883 |
CDK1 |
0.816 | 0.724 | 1 | 0.858 |
CDK13 |
0.816 | 0.727 | 1 | 0.852 |
JNK3 |
0.815 | 0.781 | 1 | 0.848 |
CDK5 |
0.814 | 0.697 | 1 | 0.812 |
ERK1 |
0.814 | 0.731 | 1 | 0.854 |
CDK12 |
0.810 | 0.721 | 1 | 0.869 |
DYRK2 |
0.810 | 0.649 | 1 | 0.800 |
CDK9 |
0.810 | 0.716 | 1 | 0.845 |
P38A |
0.809 | 0.716 | 1 | 0.782 |
HIPK2 |
0.809 | 0.648 | 1 | 0.872 |
DYRK4 |
0.806 | 0.671 | 1 | 0.881 |
ERK2 |
0.805 | 0.734 | 1 | 0.806 |
CDK14 |
0.805 | 0.706 | 1 | 0.837 |
NLK |
0.804 | 0.633 | 1 | 0.592 |
CDK2 |
0.803 | 0.583 | 1 | 0.746 |
CDK4 |
0.801 | 0.715 | 1 | 0.876 |
CLK3 |
0.800 | 0.415 | 1 | 0.554 |
CDK10 |
0.800 | 0.660 | 1 | 0.852 |
DYRK1B |
0.799 | 0.640 | 1 | 0.835 |
CDK6 |
0.798 | 0.688 | 1 | 0.852 |
JNK1 |
0.796 | 0.704 | 1 | 0.867 |
ERK5 |
0.795 | 0.357 | 1 | 0.505 |
HIPK4 |
0.795 | 0.373 | 1 | 0.596 |
HIPK1 |
0.794 | 0.580 | 1 | 0.780 |
HIPK3 |
0.790 | 0.565 | 1 | 0.745 |
SRPK1 |
0.788 | 0.260 | -3 | 0.652 |
DYRK1A |
0.788 | 0.508 | 1 | 0.750 |
MTOR |
0.786 | 0.171 | 1 | 0.380 |
CLK1 |
0.782 | 0.331 | -3 | 0.681 |
DYRK3 |
0.781 | 0.454 | 1 | 0.749 |
SRPK2 |
0.779 | 0.202 | -3 | 0.587 |
COT |
0.778 | -0.115 | 2 | 0.772 |
CLK4 |
0.778 | 0.299 | -3 | 0.691 |
FAM20C |
0.777 | 0.190 | 2 | 0.795 |
ICK |
0.776 | 0.269 | -3 | 0.750 |
CLK2 |
0.775 | 0.327 | -3 | 0.652 |
PRPK |
0.774 | -0.094 | -1 | 0.843 |
PRP4 |
0.774 | 0.391 | -3 | 0.701 |
CDKL5 |
0.774 | 0.098 | -3 | 0.712 |
CDC7 |
0.773 | -0.121 | 1 | 0.230 |
CDKL1 |
0.773 | 0.077 | -3 | 0.721 |
TBK1 |
0.771 | -0.167 | 1 | 0.181 |
CAMK1B |
0.770 | -0.042 | -3 | 0.803 |
DSTYK |
0.770 | -0.106 | 2 | 0.780 |
PDHK4 |
0.769 | -0.130 | 1 | 0.276 |
CAMK2G |
0.769 | -0.039 | 2 | 0.746 |
IKKB |
0.768 | -0.140 | -2 | 0.788 |
ULK2 |
0.768 | -0.192 | 2 | 0.689 |
GCN2 |
0.768 | -0.213 | 2 | 0.689 |
IKKE |
0.768 | -0.168 | 1 | 0.181 |
BMPR2 |
0.768 | -0.164 | -2 | 0.885 |
ATR |
0.767 | -0.070 | 1 | 0.270 |
SRPK3 |
0.766 | 0.161 | -3 | 0.634 |
MST4 |
0.766 | -0.060 | 2 | 0.709 |
MOS |
0.765 | -0.103 | 1 | 0.272 |
PDHK1 |
0.765 | -0.167 | 1 | 0.258 |
PRKD1 |
0.765 | -0.059 | -3 | 0.733 |
RAF1 |
0.764 | -0.226 | 1 | 0.214 |
NEK6 |
0.764 | -0.106 | -2 | 0.848 |
PRKD2 |
0.764 | -0.031 | -3 | 0.685 |
MAK |
0.764 | 0.403 | -2 | 0.710 |
MOK |
0.764 | 0.382 | 1 | 0.674 |
WNK1 |
0.764 | -0.098 | -2 | 0.841 |
PIM3 |
0.763 | -0.083 | -3 | 0.733 |
DNAPK |
0.762 | 0.004 | 1 | 0.239 |
NDR2 |
0.762 | -0.076 | -3 | 0.743 |
PKN3 |
0.761 | -0.084 | -3 | 0.757 |
ATM |
0.761 | -0.043 | 1 | 0.235 |
NEK7 |
0.761 | -0.193 | -3 | 0.789 |
NUAK2 |
0.760 | -0.044 | -3 | 0.763 |
ERK7 |
0.760 | 0.207 | 2 | 0.424 |
CAMLCK |
0.760 | -0.057 | -2 | 0.829 |
NIK |
0.760 | -0.122 | -3 | 0.824 |
RSK2 |
0.759 | -0.044 | -3 | 0.689 |
NDR1 |
0.759 | -0.089 | -3 | 0.752 |
ULK1 |
0.759 | -0.182 | -3 | 0.778 |
BCKDK |
0.759 | -0.132 | -1 | 0.816 |
MAPKAPK3 |
0.758 | -0.083 | -3 | 0.693 |
TGFBR2 |
0.758 | -0.115 | -2 | 0.783 |
PIM1 |
0.757 | -0.019 | -3 | 0.690 |
IKKA |
0.757 | -0.084 | -2 | 0.776 |
CAMK2D |
0.757 | -0.088 | -3 | 0.785 |
P70S6KB |
0.757 | -0.047 | -3 | 0.729 |
TGFBR1 |
0.756 | -0.005 | -2 | 0.790 |
WNK3 |
0.756 | -0.209 | 1 | 0.212 |
MARK4 |
0.756 | -0.090 | 4 | 0.787 |
TSSK2 |
0.756 | -0.083 | -5 | 0.801 |
NIM1 |
0.756 | -0.094 | 3 | 0.732 |
GRK5 |
0.755 | -0.140 | -3 | 0.823 |
P90RSK |
0.755 | -0.063 | -3 | 0.682 |
RIPK3 |
0.755 | -0.189 | 3 | 0.709 |
PAK6 |
0.755 | -0.027 | -2 | 0.697 |
MAPKAPK2 |
0.755 | -0.045 | -3 | 0.635 |
CHAK2 |
0.754 | -0.123 | -1 | 0.823 |
RSK3 |
0.754 | -0.074 | -3 | 0.682 |
DAPK2 |
0.754 | -0.105 | -3 | 0.805 |
ALK4 |
0.754 | -0.034 | -2 | 0.817 |
GRK6 |
0.754 | -0.090 | 1 | 0.217 |
PKN2 |
0.754 | -0.119 | -3 | 0.777 |
LATS2 |
0.754 | -0.072 | -5 | 0.742 |
PINK1 |
0.754 | 0.123 | 1 | 0.425 |
PKCD |
0.753 | -0.088 | 2 | 0.654 |
SKMLCK |
0.753 | -0.106 | -2 | 0.805 |
NEK9 |
0.753 | -0.223 | 2 | 0.712 |
MLK1 |
0.753 | -0.203 | 2 | 0.689 |
BMPR1B |
0.753 | -0.032 | 1 | 0.206 |
PRKD3 |
0.753 | -0.049 | -3 | 0.673 |
AMPKA1 |
0.752 | -0.113 | -3 | 0.780 |
TSSK1 |
0.751 | -0.086 | -3 | 0.793 |
IRE1 |
0.751 | -0.147 | 1 | 0.218 |
HUNK |
0.751 | -0.202 | 2 | 0.708 |
GRK1 |
0.751 | -0.060 | -2 | 0.769 |
CAMK2B |
0.750 | -0.025 | 2 | 0.752 |
MASTL |
0.749 | -0.226 | -2 | 0.839 |
PKACG |
0.749 | -0.071 | -2 | 0.741 |
MLK2 |
0.749 | -0.192 | 2 | 0.704 |
PLK1 |
0.749 | -0.113 | -2 | 0.832 |
SMG1 |
0.749 | -0.071 | 1 | 0.251 |
PKR |
0.748 | -0.122 | 1 | 0.239 |
NEK2 |
0.748 | -0.164 | 2 | 0.690 |
VRK2 |
0.748 | -0.055 | 1 | 0.325 |
MNK2 |
0.747 | -0.081 | -2 | 0.778 |
MEK1 |
0.747 | -0.134 | 2 | 0.749 |
RIPK1 |
0.747 | -0.225 | 1 | 0.209 |
ANKRD3 |
0.747 | -0.226 | 1 | 0.237 |
ALK2 |
0.747 | -0.024 | -2 | 0.795 |
IRE2 |
0.747 | -0.130 | 2 | 0.637 |
NUAK1 |
0.746 | -0.084 | -3 | 0.721 |
MELK |
0.746 | -0.118 | -3 | 0.743 |
AMPKA2 |
0.746 | -0.101 | -3 | 0.746 |
PLK3 |
0.746 | -0.076 | 2 | 0.710 |
CAMK4 |
0.746 | -0.145 | -3 | 0.767 |
PAK3 |
0.746 | -0.123 | -2 | 0.761 |
QIK |
0.745 | -0.130 | -3 | 0.793 |
LATS1 |
0.744 | -0.028 | -3 | 0.745 |
PAK1 |
0.744 | -0.097 | -2 | 0.744 |
ACVR2A |
0.744 | -0.075 | -2 | 0.785 |
GRK7 |
0.744 | -0.004 | 1 | 0.234 |
DLK |
0.744 | -0.262 | 1 | 0.231 |
MLK3 |
0.744 | -0.127 | 2 | 0.613 |
TTBK2 |
0.744 | -0.211 | 2 | 0.622 |
MPSK1 |
0.743 | 0.005 | 1 | 0.285 |
CAMK2A |
0.743 | -0.045 | 2 | 0.731 |
PHKG1 |
0.743 | -0.134 | -3 | 0.751 |
PIM2 |
0.743 | -0.025 | -3 | 0.680 |
CHK1 |
0.743 | -0.088 | -3 | 0.748 |
AURC |
0.742 | -0.051 | -2 | 0.624 |
SGK3 |
0.742 | -0.054 | -3 | 0.692 |
ACVR2B |
0.742 | -0.086 | -2 | 0.796 |
PLK4 |
0.741 | -0.137 | 2 | 0.569 |
BMPR1A |
0.741 | -0.030 | 1 | 0.196 |
GRK4 |
0.741 | -0.183 | -2 | 0.778 |
PKCG |
0.740 | -0.109 | 2 | 0.604 |
YSK4 |
0.740 | -0.211 | 1 | 0.194 |
PKCB |
0.739 | -0.102 | 2 | 0.605 |
PKCA |
0.739 | -0.103 | 2 | 0.589 |
CHAK1 |
0.739 | -0.196 | 2 | 0.675 |
RSK4 |
0.739 | -0.051 | -3 | 0.644 |
CK2A2 |
0.739 | 0.035 | 1 | 0.173 |
QSK |
0.738 | -0.096 | 4 | 0.765 |
HRI |
0.738 | -0.180 | -2 | 0.851 |
MARK2 |
0.738 | -0.082 | 4 | 0.695 |
MSK2 |
0.738 | -0.103 | -3 | 0.649 |
PKG2 |
0.738 | -0.057 | -2 | 0.671 |
SIK |
0.737 | -0.098 | -3 | 0.700 |
PKCH |
0.737 | -0.122 | 2 | 0.597 |
PHKG2 |
0.737 | -0.112 | -3 | 0.756 |
PAK2 |
0.737 | -0.126 | -2 | 0.738 |
BRAF |
0.737 | -0.124 | -4 | 0.744 |
MARK3 |
0.737 | -0.081 | 4 | 0.728 |
MNK1 |
0.737 | -0.082 | -2 | 0.797 |
MYLK4 |
0.736 | -0.087 | -2 | 0.733 |
AKT2 |
0.736 | -0.037 | -3 | 0.614 |
IRAK4 |
0.736 | -0.161 | 1 | 0.200 |
MAPKAPK5 |
0.736 | -0.128 | -3 | 0.646 |
AURB |
0.736 | -0.070 | -2 | 0.622 |
PKCZ |
0.736 | -0.133 | 2 | 0.654 |
PERK |
0.735 | -0.179 | -2 | 0.839 |
BRSK2 |
0.735 | -0.140 | -3 | 0.761 |
WNK4 |
0.735 | -0.160 | -2 | 0.835 |
TLK2 |
0.735 | -0.170 | 1 | 0.213 |
PKACB |
0.734 | -0.043 | -2 | 0.654 |
MARK1 |
0.734 | -0.101 | 4 | 0.753 |
ZAK |
0.734 | -0.186 | 1 | 0.213 |
BRSK1 |
0.733 | -0.118 | -3 | 0.718 |
DRAK1 |
0.733 | -0.167 | 1 | 0.179 |
SNRK |
0.733 | -0.198 | 2 | 0.594 |
MLK4 |
0.733 | -0.182 | 2 | 0.605 |
GSK3A |
0.732 | 0.124 | 4 | 0.340 |
SSTK |
0.732 | -0.077 | 4 | 0.759 |
CAMKK1 |
0.732 | -0.132 | -2 | 0.837 |
P70S6K |
0.732 | -0.076 | -3 | 0.648 |
DCAMKL2 |
0.732 | -0.090 | -3 | 0.739 |
CAMK1G |
0.732 | -0.105 | -3 | 0.701 |
DCAMKL1 |
0.732 | -0.100 | -3 | 0.703 |
MEK5 |
0.732 | -0.228 | 2 | 0.720 |
TLK1 |
0.731 | -0.155 | -2 | 0.791 |
TTBK1 |
0.731 | -0.150 | 2 | 0.557 |
MST3 |
0.731 | -0.119 | 2 | 0.689 |
MEKK1 |
0.730 | -0.220 | 1 | 0.230 |
PRKX |
0.730 | -0.013 | -3 | 0.594 |
SMMLCK |
0.730 | -0.083 | -3 | 0.761 |
MEKK3 |
0.730 | -0.202 | 1 | 0.221 |
MSK1 |
0.730 | -0.086 | -3 | 0.658 |
PKCI |
0.729 | -0.089 | 2 | 0.618 |
MEKK2 |
0.729 | -0.185 | 2 | 0.696 |
PAK5 |
0.729 | -0.083 | -2 | 0.635 |
AURA |
0.729 | -0.076 | -2 | 0.569 |
TAO3 |
0.729 | -0.113 | 1 | 0.239 |
SBK |
0.729 | 0.069 | -3 | 0.496 |
AKT1 |
0.729 | -0.056 | -3 | 0.630 |
NEK5 |
0.728 | -0.226 | 1 | 0.213 |
TAO2 |
0.728 | -0.103 | 2 | 0.718 |
LKB1 |
0.728 | -0.090 | -3 | 0.791 |
CK2A1 |
0.728 | 0.016 | 1 | 0.162 |
IRAK1 |
0.728 | -0.197 | -1 | 0.755 |
PKCT |
0.728 | -0.124 | 2 | 0.604 |
GRK2 |
0.727 | -0.115 | -2 | 0.666 |
GAK |
0.727 | -0.063 | 1 | 0.270 |
CAMKK2 |
0.726 | -0.121 | -2 | 0.835 |
CAMK1D |
0.726 | -0.068 | -3 | 0.623 |
PKN1 |
0.725 | -0.088 | -3 | 0.669 |
PAK4 |
0.724 | -0.079 | -2 | 0.625 |
NEK4 |
0.723 | -0.194 | 1 | 0.197 |
PDK1 |
0.723 | -0.122 | 1 | 0.243 |
NEK11 |
0.722 | -0.205 | 1 | 0.232 |
PKACA |
0.722 | -0.050 | -2 | 0.608 |
LOK |
0.722 | -0.109 | -2 | 0.842 |
PBK |
0.721 | -0.053 | 1 | 0.244 |
HGK |
0.721 | -0.129 | 3 | 0.789 |
TNIK |
0.721 | -0.098 | 3 | 0.793 |
GSK3B |
0.721 | -0.014 | 4 | 0.328 |
MINK |
0.720 | -0.147 | 1 | 0.198 |
MEKK6 |
0.719 | -0.168 | 1 | 0.223 |
SGK1 |
0.719 | -0.017 | -3 | 0.527 |
PKCE |
0.719 | -0.074 | 2 | 0.588 |
NEK8 |
0.718 | -0.229 | 2 | 0.692 |
CK1E |
0.718 | -0.085 | -3 | 0.482 |
BIKE |
0.718 | -0.015 | 1 | 0.254 |
NEK1 |
0.718 | -0.193 | 1 | 0.194 |
MRCKB |
0.718 | -0.049 | -3 | 0.681 |
MAP3K15 |
0.718 | -0.172 | 1 | 0.218 |
MRCKA |
0.717 | -0.051 | -3 | 0.693 |
LRRK2 |
0.717 | -0.107 | 2 | 0.726 |
RIPK2 |
0.716 | -0.205 | 1 | 0.189 |
MST2 |
0.716 | -0.181 | 1 | 0.209 |
EEF2K |
0.715 | -0.133 | 3 | 0.773 |
PASK |
0.715 | -0.126 | -3 | 0.752 |
HPK1 |
0.715 | -0.133 | 1 | 0.216 |
GCK |
0.715 | -0.159 | 1 | 0.219 |
CHK2 |
0.715 | -0.078 | -3 | 0.570 |
MEK2 |
0.715 | -0.186 | 2 | 0.720 |
BUB1 |
0.714 | -0.049 | -5 | 0.720 |
AKT3 |
0.714 | -0.049 | -3 | 0.536 |
NEK3 |
0.714 | -0.158 | 1 | 0.218 |
CK1D |
0.713 | -0.058 | -3 | 0.439 |
CAMK1A |
0.713 | -0.073 | -3 | 0.585 |
DAPK3 |
0.713 | -0.097 | -3 | 0.718 |
YSK1 |
0.713 | -0.154 | 2 | 0.674 |
TAK1 |
0.712 | -0.206 | 1 | 0.205 |
MST1 |
0.712 | -0.174 | 1 | 0.196 |
PLK2 |
0.712 | -0.075 | -3 | 0.725 |
KHS1 |
0.712 | -0.118 | 1 | 0.212 |
AAK1 |
0.712 | 0.008 | 1 | 0.251 |
ROCK2 |
0.712 | -0.062 | -3 | 0.711 |
SLK |
0.712 | -0.105 | -2 | 0.790 |
VRK1 |
0.710 | -0.229 | 2 | 0.725 |
KHS2 |
0.710 | -0.092 | 1 | 0.223 |
STK33 |
0.709 | -0.161 | 2 | 0.538 |
GRK3 |
0.709 | -0.119 | -2 | 0.603 |
DMPK1 |
0.708 | -0.022 | -3 | 0.697 |
HASPIN |
0.707 | -0.041 | -1 | 0.654 |
CK1G1 |
0.707 | -0.124 | -3 | 0.466 |
CK1A2 |
0.707 | -0.084 | -3 | 0.436 |
PDHK3_TYR |
0.706 | 0.097 | 4 | 0.850 |
DAPK1 |
0.704 | -0.107 | -3 | 0.703 |
PKG1 |
0.703 | -0.080 | -2 | 0.592 |
TAO1 |
0.701 | -0.128 | 1 | 0.205 |
ASK1 |
0.701 | -0.153 | 1 | 0.217 |
ROCK1 |
0.701 | -0.071 | -3 | 0.691 |
PKMYT1_TYR |
0.700 | 0.058 | 3 | 0.809 |
CRIK |
0.700 | -0.047 | -3 | 0.621 |
LIMK2_TYR |
0.699 | 0.054 | -3 | 0.843 |
MYO3A |
0.699 | -0.123 | 1 | 0.218 |
MYO3B |
0.699 | -0.133 | 2 | 0.695 |
TESK1_TYR |
0.698 | -0.022 | 3 | 0.832 |
OSR1 |
0.698 | -0.138 | 2 | 0.682 |
TTK |
0.695 | -0.139 | -2 | 0.804 |
MAP2K4_TYR |
0.695 | -0.051 | -1 | 0.857 |
ALPHAK3 |
0.695 | -0.080 | -1 | 0.761 |
MAP2K7_TYR |
0.694 | -0.114 | 2 | 0.759 |
MAP2K6_TYR |
0.694 | -0.009 | -1 | 0.855 |
PDHK4_TYR |
0.692 | -0.018 | 2 | 0.774 |
BMPR2_TYR |
0.692 | -0.014 | -1 | 0.831 |
PINK1_TYR |
0.691 | -0.152 | 1 | 0.268 |
LIMK1_TYR |
0.690 | -0.049 | 2 | 0.751 |
RET |
0.689 | -0.152 | 1 | 0.237 |
EPHA6 |
0.689 | -0.083 | -1 | 0.850 |
JAK2 |
0.689 | -0.130 | 1 | 0.246 |
STLK3 |
0.688 | -0.178 | 1 | 0.193 |
TYK2 |
0.687 | -0.200 | 1 | 0.225 |
PDHK1_TYR |
0.687 | -0.084 | -1 | 0.873 |
MST1R |
0.685 | -0.153 | 3 | 0.769 |
NEK10_TYR |
0.684 | -0.111 | 1 | 0.194 |
DDR1 |
0.684 | -0.107 | 4 | 0.769 |
CSF1R |
0.684 | -0.126 | 3 | 0.754 |
EPHB4 |
0.684 | -0.133 | -1 | 0.854 |
ROS1 |
0.683 | -0.170 | 3 | 0.731 |
ABL2 |
0.683 | -0.118 | -1 | 0.829 |
YES1 |
0.682 | -0.094 | -1 | 0.838 |
TNNI3K_TYR |
0.681 | -0.074 | 1 | 0.267 |
TYRO3 |
0.681 | -0.190 | 3 | 0.757 |
JAK1 |
0.681 | -0.117 | 1 | 0.211 |
TEK |
0.681 | -0.023 | 3 | 0.699 |
FGFR1 |
0.680 | -0.047 | 3 | 0.729 |
YANK3 |
0.679 | -0.096 | 2 | 0.360 |
JAK3 |
0.679 | -0.151 | 1 | 0.229 |
FGFR2 |
0.679 | -0.058 | 3 | 0.738 |
ABL1 |
0.679 | -0.129 | -1 | 0.821 |
EPHA4 |
0.678 | -0.077 | 2 | 0.698 |
TXK |
0.677 | -0.114 | 1 | 0.202 |
EPHB2 |
0.676 | -0.120 | -1 | 0.841 |
INSRR |
0.676 | -0.123 | 3 | 0.707 |
TNK1 |
0.676 | -0.125 | 3 | 0.740 |
EPHB1 |
0.675 | -0.158 | 1 | 0.205 |
HCK |
0.675 | -0.151 | -1 | 0.818 |
FER |
0.675 | -0.182 | 1 | 0.221 |
PDGFRB |
0.674 | -0.202 | 3 | 0.766 |
SRMS |
0.674 | -0.158 | 1 | 0.199 |
EPHB3 |
0.673 | -0.154 | -1 | 0.848 |
KIT |
0.673 | -0.146 | 3 | 0.754 |
FLT3 |
0.673 | -0.181 | 3 | 0.752 |
ITK |
0.672 | -0.162 | -1 | 0.801 |
LCK |
0.672 | -0.129 | -1 | 0.816 |
BLK |
0.672 | -0.104 | -1 | 0.830 |
FGR |
0.672 | -0.201 | 1 | 0.208 |
AXL |
0.672 | -0.172 | 3 | 0.732 |
TNK2 |
0.671 | -0.166 | 3 | 0.731 |
DDR2 |
0.671 | -0.039 | 3 | 0.698 |
MERTK |
0.669 | -0.165 | 3 | 0.736 |
KDR |
0.669 | -0.142 | 3 | 0.721 |
PDGFRA |
0.669 | -0.222 | 3 | 0.766 |
BTK |
0.669 | -0.189 | -1 | 0.775 |
WEE1_TYR |
0.668 | -0.105 | -1 | 0.755 |
EPHA7 |
0.668 | -0.121 | 2 | 0.697 |
TEC |
0.668 | -0.147 | -1 | 0.763 |
CK1A |
0.666 | -0.108 | -3 | 0.346 |
FGFR3 |
0.666 | -0.081 | 3 | 0.716 |
ALK |
0.666 | -0.170 | 3 | 0.698 |
LTK |
0.665 | -0.166 | 3 | 0.718 |
BMX |
0.665 | -0.137 | -1 | 0.728 |
EPHA3 |
0.664 | -0.133 | 2 | 0.668 |
ERBB2 |
0.664 | -0.164 | 1 | 0.205 |
FLT4 |
0.664 | -0.153 | 3 | 0.713 |
FYN |
0.663 | -0.103 | -1 | 0.775 |
NTRK2 |
0.663 | -0.199 | 3 | 0.725 |
NTRK1 |
0.663 | -0.201 | -1 | 0.816 |
PTK2B |
0.663 | -0.115 | -1 | 0.800 |
MET |
0.663 | -0.166 | 3 | 0.749 |
EGFR |
0.662 | -0.093 | 1 | 0.177 |
INSR |
0.662 | -0.158 | 3 | 0.686 |
FRK |
0.662 | -0.170 | -1 | 0.849 |
LYN |
0.661 | -0.140 | 3 | 0.692 |
EPHA1 |
0.661 | -0.180 | 3 | 0.723 |
EPHA8 |
0.659 | -0.119 | -1 | 0.820 |
FLT1 |
0.659 | -0.168 | -1 | 0.817 |
EPHA5 |
0.659 | -0.126 | 2 | 0.692 |
NTRK3 |
0.658 | -0.162 | -1 | 0.776 |
MUSK |
0.657 | -0.139 | 1 | 0.161 |
PTK6 |
0.657 | -0.228 | -1 | 0.745 |
SRC |
0.656 | -0.129 | -1 | 0.791 |
FGFR4 |
0.655 | -0.102 | -1 | 0.782 |
MATK |
0.654 | -0.126 | -1 | 0.763 |
CSK |
0.654 | -0.153 | 2 | 0.699 |
EPHA2 |
0.649 | -0.128 | -1 | 0.778 |
CK1G3 |
0.648 | -0.104 | -3 | 0.299 |
YANK2 |
0.647 | -0.112 | 2 | 0.380 |
PTK2 |
0.647 | -0.098 | -1 | 0.719 |
ERBB4 |
0.647 | -0.103 | 1 | 0.184 |
IGF1R |
0.646 | -0.146 | 3 | 0.632 |
SYK |
0.643 | -0.115 | -1 | 0.739 |
FES |
0.634 | -0.150 | -1 | 0.707 |
ZAP70 |
0.622 | -0.116 | -1 | 0.663 |
CK1G2 |
0.621 | -0.114 | -3 | 0.392 |