Motif 327 (n=173)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S3034 | ochoa | Snf2 related CREBBP activator protein | None |
| A6NCL7 | ANKRD33B | S416 | ochoa | Ankyrin repeat domain-containing protein 33B | None |
| A6NHR9 | SMCHD1 | S293 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| A8K0R7 | ZNF839 | S316 | ochoa | Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) | None |
| E9PCH4 | None | S1120 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| O00257 | CBX4 | S415 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O14526 | FCHO1 | S570 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14746 | TERT | S227 | psp | Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2) | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. {ECO:0000269|PubMed:14963003, ECO:0000269|PubMed:15082768, ECO:0000269|PubMed:15857955, ECO:0000269|PubMed:17026956, ECO:0000269|PubMed:17264120, ECO:0000269|PubMed:17296728, ECO:0000269|PubMed:17548608, ECO:0000269|PubMed:19188162, ECO:0000269|PubMed:19567472, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:19777057, ECO:0000269|PubMed:9389643}. |
| O14746 | TERT | S824 | psp | Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2) | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. {ECO:0000269|PubMed:14963003, ECO:0000269|PubMed:15082768, ECO:0000269|PubMed:15857955, ECO:0000269|PubMed:17026956, ECO:0000269|PubMed:17264120, ECO:0000269|PubMed:17296728, ECO:0000269|PubMed:17548608, ECO:0000269|PubMed:19188162, ECO:0000269|PubMed:19567472, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:19777057, ECO:0000269|PubMed:9389643}. |
| O14874 | BCKDK | S33 | ochoa | Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4) | Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:24449431, PubMed:29779826, PubMed:37558654). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-337, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (PubMed:29779826, PubMed:37558654). Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxxE/D canonical motif (PubMed:29779826). {ECO:0000269|PubMed:24449431, ECO:0000269|PubMed:29779826, ECO:0000269|PubMed:37558654}. |
| O14976 | GAK | S26 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15047 | SETD1A | S222 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15169 | AXIN1 | S579 | ochoa | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| O43149 | ZZEF1 | S1537 | ochoa | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}. |
| O43312 | MTSS1 | S594 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O43933 | PEX1 | S1211 | ochoa | Peroxisomal ATPase PEX1 (EC 3.6.4.-) (Peroxin-1) (Peroxisome biogenesis disorder protein 1) (Peroxisome biogenesis factor 1) | Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:11439091, PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772). {ECO:0000269|PubMed:11439091, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118, ECO:0000269|PubMed:29884772}. |
| O60343 | TBC1D4 | S341 | ochoa|psp | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O75385 | ULK1 | S775 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75390 | CS | S97 | ochoa | Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) | Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}. |
| O95948 | ONECUT2 | S317 | ochoa | One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2) | Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B. |
| P06737 | PYGL | S430 | ochoa | Glycogen phosphorylase, liver form (EC 2.4.1.1) | Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:22225877}. |
| P10109 | FDX1 | S63 | ochoa | Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin) | Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}. |
| P10398 | ARAF | S214 | ochoa|psp | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P11216 | PYGB | S430 | ochoa | Glycogen phosphorylase, brain form (EC 2.4.1.1) | Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228). {ECO:0000269|PubMed:27402852, ECO:0000303|PubMed:3346228}. |
| P11217 | PYGM | S430 | ochoa | Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) | Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:8316268}. |
| P15056 | BRAF | S365 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P21709 | EPHA1 | S908 | ochoa | Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}. |
| P22413 | ENPP1 | S34 | ochoa | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Membrane component chromosome 6 surface marker 1) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] | Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:25344812, PubMed:27467858, PubMed:28011303, PubMed:35147247, PubMed:8001561). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:27467858, PubMed:8001561). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717). Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear (PubMed:25344812). Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812). {ECO:0000250|UniProtKB:P06802, ECO:0000269|PubMed:10615944, ECO:0000269|PubMed:25344812, ECO:0000269|PubMed:27467858, ECO:0000269|PubMed:28011303, ECO:0000269|PubMed:28964717, ECO:0000269|PubMed:35147247, ECO:0000269|PubMed:8001561, ECO:0000305|PubMed:11004006}. |
| P25440 | BRD2 | S37 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P28070 | PSMB4 | S26 | ochoa | Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3) (Proteasome subunit beta-7) (beta-7) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P29317 | EPHA2 | S899 | ochoa | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P29474 | NOS3 | S1177 | ochoa|psp | Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. |
| P35368 | ADRA1B | S470 | ochoa | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P35568 | IRS1 | S270 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P36871 | PGM1 | S346 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P41594 | GRM5 | S1020 | ochoa | Metabotropic glutamate receptor 5 (mGluR5) | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}. |
| P46013 | MKI67 | S3041 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P47736 | RAP1GAP | S441 | ochoa|psp | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P47974 | ZFP36L2 | S125 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48634 | PRRC2A | S1085 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49815 | TSC2 | S981 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P63000 | RAC1 | S71 | psp | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:1643658, PubMed:22843693, PubMed:23512198, PubMed:28886345). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:1643658). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity). Required for DSG3 translocation to cell-cell junctions, DSG3-mediated organization of cortical F-actin bundles and anchoring of actin at cell junctions; via interaction with DSG3 (PubMed:22796473). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:38355798). {ECO:0000250|UniProtKB:P63001, ECO:0000250|UniProtKB:Q6RUV5, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:22843693, ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:28886345, ECO:0000269|PubMed:38355798, ECO:0000269|PubMed:9121475}.; FUNCTION: [Isoform B]: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins (PubMed:14625275). It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction (PubMed:14625275). {ECO:0000269|PubMed:14625275}. |
| P98177 | FOXO4 | S262 | psp | Forkhead box protein O4 (Fork head domain transcription factor AFX1) | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}. |
| Q00587 | CDC42EP1 | S180 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q07352 | ZFP36L1 | S92 | ochoa|psp | mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}. |
| Q0VF96 | CGNL1 | S297 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q13009 | TIAM1 | S695 | ochoa|psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13330 | MTA1 | S52 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q13472 | TOP3A | S971 | ochoa | DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 (PubMed:29290614). {ECO:0000269|PubMed:20445207, ECO:0000269|PubMed:29290614, ECO:0000269|PubMed:30057030, ECO:0000269|PubMed:8622991}. |
| Q14432 | PDE3A | S294 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14432 | PDE3A | S465 | psp | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14678 | KANK1 | S186 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q14678 | KANK1 | S325 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q14680 | MELK | S336 | ochoa|psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14764 | MVP | S585 | ochoa | Major vault protein (MVP) (Lung resistance-related protein) | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}. |
| Q14CZ0 | HAPSTR1 | S173 | ochoa | HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein) | Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365). {ECO:0000269|PubMed:33660365, ECO:0000269|PubMed:35776542}. |
| Q15345 | LRRC41 | S276 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
| Q15643 | TRIP11 | S1854 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15811 | ITSN1 | S315 | ochoa | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}. |
| Q53GL0 | PLEKHO1 | S227 | ochoa | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}. |
| Q5FWE3 | PRRT3 | S854 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5JSZ5 | PRRC2B | S416 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JSZ5 | PRRC2B | S1132 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SW79 | CEP170 | S1019 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5VWQ8 | DAB2IP | S1031 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q5VZ46 | KIAA1614 | S1107 | ochoa | Uncharacterized protein KIAA1614 | None |
| Q5VZL5 | ZMYM4 | S1181 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q5VZP5 | STYXL2 | S470 | ochoa | Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27) | May be required for myofiber maturation. {ECO:0000250|UniProtKB:F1QWM2}. |
| Q659A1 | ICE2 | S457 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q66K64 | DCAF15 | S359 | ochoa | DDB1- and CUL4-associated factor 15 | Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}. |
| Q684P5 | RAP1GAP2 | S507 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
| Q6ICG6 | KIAA0930 | S353 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6IQ19 | CCSAP | S240 | ochoa | Centriole, cilia and spindle-associated protein | Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity). {ECO:0000250|UniProtKB:Q6P3G4, ECO:0000269|PubMed:26562023}. |
| Q6IQ23 | PLEKHA7 | S634 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6PIY7 | TENT2 | S95 | ochoa | Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}. |
| Q6ZRS2 | SRCAP | S3211 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q76N89 | HECW1 | S1075 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Q7L2J0 | MEPCE | S175 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z2K8 | GPRIN1 | S389 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2W4 | ZC3HAV1 | S249 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z417 | NUFIP2 | S304 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z591 | AKNA | S1161 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q86SQ0 | PHLDB2 | S242 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86SQ0 | PHLDB2 | S384 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86SQ0 | PHLDB2 | S415 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86VM9 | ZC3H18 | S893 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86VQ6 | TXNRD3 | S42 | ochoa | Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase 3 intronic transcript 1) (Thioredoxin reductase 3 neighbor gene) (Thioredoxin reductase TR2) | Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250|UniProtKB:Q99MD6}. |
| Q86Y82 | STX12 | S139 | ochoa | Syntaxin-12 | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}. |
| Q86YR5 | GPSM1 | S469 | ochoa | G-protein-signaling modulator 1 (Activator of G-protein signaling 3) | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}. |
| Q86YV0 | RASAL3 | S164 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IV50 | LYSMD2 | S33 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 2 | None |
| Q8IYI6 | EXOC8 | S151 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8N122 | RPTOR | S721 | ochoa|psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N1G0 | ZNF687 | S1118 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N3D4 | EHBP1L1 | S1257 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3J3 | HROB | S46 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N4C8 | MINK1 | S701 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N4X5 | AFAP1L2 | S651 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N5S9 | CAMKK1 | S52 | ochoa | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8N9B5 | JMY | S889 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NBV4 | PLPP7 | S62 | ochoa | Inactive phospholipid phosphatase 7 (Phosphatidic acid phosphatase type 2 domain-containing protein 3) | Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). {ECO:0000250}. |
| Q8NEV8 | EXPH5 | S1821 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NFZ0 | FBH1 | S126 | ochoa | F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18) | 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578). {ECO:0000269|PubMed:11956208, ECO:0000269|PubMed:17724085, ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23361013, ECO:0000269|PubMed:25585578, ECO:0000269|PubMed:25772361}. |
| Q8TAA9 | VANGL1 | S339 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TCN5 | ZNF507 | S487 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TD20 | SLC2A12 | S244 | ochoa | Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12) | Insulin-independent facilitative glucose transporter. {ECO:0000250|UniProtKB:Q8BFW9}. |
| Q8TDM6 | DLG5 | S1075 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDN4 | CABLES1 | S242 | psp | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q8TEU7 | RAPGEF6 | S1070 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TEW0 | PARD3 | S1178 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF72 | SHROOM3 | S1118 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WU20 | FRS2 | S327 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WV28 | BLNK | S285 | psp | B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}. |
| Q8WVM0 | TFB1M | S296 | ochoa | Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (h-mtTFB) (h-mtTFB1) (hTFB1M) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1) | Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome (PubMed:12496758, PubMed:25305075, PubMed:31251801). Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (PubMed:11809803, PubMed:12068295, PubMed:12897151). {ECO:0000269|PubMed:11809803, ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12496758, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:25305075, ECO:0000269|PubMed:31251801}. |
| Q8WWQ0 | PHIP | S1315 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q92502 | STARD8 | S481 | ochoa | StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) | Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. {ECO:0000269|PubMed:17976533}. |
| Q92625 | ANKS1A | S887 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92736 | RYR2 | S2808 | ochoa|psp | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}. |
| Q96D71 | REPS1 | S709 | ochoa|psp | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96FS4 | SIPA1 | S74 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96FT9 | IFT43 | S78 | ochoa | Intraflagellar transport protein 43 homolog | As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (PubMed:28400947, PubMed:28973684). Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (PubMed:21378380). {ECO:0000269|PubMed:21378380, ECO:0000269|PubMed:28400947, ECO:0000269|PubMed:28973684}. |
| Q96K30 | RITA1 | S248 | ochoa | RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein) | Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}. |
| Q96NY7 | CLIC6 | S293 | ochoa | Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:37838179}. |
| Q96QB1 | DLC1 | S1004 | psp | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q99501 | GAS2L1 | S438 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99683 | MAP3K5 | S83 | psp | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q9BV36 | MLPH | S337 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BWH6 | RPAP1 | S266 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BXA9 | SALL3 | S1177 | ochoa | Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3) | Probable transcription factor. |
| Q9BZ23 | PANK2 | S169 | ochoa|psp | Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)] | [Isoform 1]: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:17825826). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726). {ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:16272150, ECO:0000269|PubMed:17242360, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:30221726}.; FUNCTION: [Isoform 4]: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:16272150}. |
| Q9C0C2 | TNKS1BP1 | S1666 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0X6 | RNF208 | S102 | ochoa | RING finger protein 208 | None |
| Q9H2J7 | SLC6A15 | S129 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H2Y7 | ZNF106 | S861 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H3T3 | SEMA6B | S802 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H6Q3 | SLA2 | S131 | ochoa | Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2) | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}. |
| Q9H7P9 | PLEKHG2 | S482 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H974 | QTRT2 | S237 | ochoa | Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1) | Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). {ECO:0000255|HAMAP-Rule:MF_03043, ECO:0000269|PubMed:34009357, ECO:0000269|PubMed:34241577}. |
| Q9HBI1 | PARVB | S39 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
| Q9HBL0 | TNS1 | S1024 | psp | Tensin-1 (EC 3.1.3.-) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}. |
| Q9NQV6 | PRDM10 | S418 | ochoa | PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) | Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}. |
| Q9NZJ5 | EIF2AK3 | S555 | ochoa | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:10026192, ECO:0000269|PubMed:10677345, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:12086964, ECO:0000269|PubMed:25925385, ECO:0000269|PubMed:27917829, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:39116259}. |
| Q9P227 | ARHGAP23 | S316 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P286 | PAK5 | S288 | psp | Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}. |
| Q9P2F6 | ARHGAP20 | S704 | ochoa | Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2H5 | USP35 | S613 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) | Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed:26348204, PubMed:29449677, PubMed:37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed:26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed:29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed:34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed:25915564). {ECO:0000269|PubMed:25915564, ECO:0000269|PubMed:26348204, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:34438346, ECO:0000269|PubMed:37004621}. |
| Q9P2K5 | MYEF2 | S520 | ochoa | Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156) | Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}. |
| Q9P2P5 | HECW2 | S1042 | ochoa | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269|PubMed:12890487, ECO:0000269|PubMed:24163370}. |
| Q9P2Y5 | UVRAG | S509 | ochoa | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UBP6 | METTL1 | S27 | ochoa|psp | tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (miRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) | Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985, PubMed:37369656, PubMed:37379838). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352206, PubMed:34352207, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084, PubMed:37379838). Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation (PubMed:31031084, PubMed:37379838). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity). {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000269|PubMed:12403464, ECO:0000269|PubMed:31031083, ECO:0000269|PubMed:31031084, ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:36599982, ECO:0000269|PubMed:36599985, ECO:0000269|PubMed:37369656, ECO:0000269|PubMed:37379838}. |
| Q9UDY2 | TJP2 | S240 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UGI0 | ZRANB1 | S78 | psp | Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1) | Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Required in the stress fiber dynamics and cell migration (PubMed:21834987). {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:33637724}. |
| Q9UGU0 | TCF20 | S1007 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9ULL8 | SHROOM4 | S1059 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9UNN5 | FAF1 | S582 | ochoa|psp | FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) | Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}. |
| Q9UPV7 | PHF24 | S241 | ochoa | PHD finger protein 24 | None |
| Q9Y210 | TRPC6 | S94 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y2B1 | RXYLT1 | S59 | ochoa | Ribitol-5-phosphate xylosyltransferase 1 (EC 2.4.2.61) (Transmembrane protein 5) (UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase) | Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan (Probable) (PubMed:27733679, PubMed:29477842). Participates in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (Probable) (PubMed:25279699, PubMed:27601598, PubMed:27733679). {ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:27601598, ECO:0000269|PubMed:27733679, ECO:0000269|PubMed:29477842, ECO:0000305|PubMed:27130732}. |
| Q9Y2V2 | CARHSP1 | S52 | ochoa|psp | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
| Q9Y4E6 | WDR7 | S1154 | ochoa | WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) | None |
| Q9Y4F5 | CEP170B | S1179 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4H2 | IRS2 | S577 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y520 | PRRC2C | S1242 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y577 | TRIM17 | S59 | ochoa | E3 ubiquitin-protein ligase TRIM17 (EC 2.3.2.27) (RING finger protein 16) (RING-type E3 ubiquitin transferase TRIM17) (Testis RING finger protein) (Tripartite motif-containing protein 17) | E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:19358823, PubMed:22023800, PubMed:27562068). Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation (PubMed:22023800). Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (PubMed:27562068). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (PubMed:19358823). {ECO:0000250|UniProtKB:Q7TPM3, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:22023800, ECO:0000269|PubMed:27562068}. |
| Q9Y5K6 | CD2AP | S233 | ochoa|psp | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y618 | NCOR2 | S2426 | psp | Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) | Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045, PubMed:20812024, PubMed:22230954, PubMed:23911289). Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3 (PubMed:22230954). Required to activate the histone deacetylase activity of HDAC3 (PubMed:22230954). Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival (PubMed:18212045, PubMed:23911289). Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:10077563, ECO:0000269|PubMed:10097068, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:22230954, ECO:0000269|PubMed:23911289}.; FUNCTION: [Isoform 1]: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. {ECO:0000269|PubMed:15632172}.; FUNCTION: [Isoform 4]: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. {ECO:0000269|PubMed:15632172}. |
| P53602 | MVD | S231 | Sugiyama | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419}. |
| Q9Y534 | CSDC2 | S58 | GPS6 | Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) | RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}. |
| Q16626 | MEA1 | S163 | Sugiyama | Male-enhanced antigen 1 (MEA-1) | May play an important role in spermatogenesis and/or testis development. |
| Q15118 | PDK1 | S25 | EPSD | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}. |
| O96004 | HAND1 | S109 | ELM | Heart- and neural crest derivatives-expressed protein 1 (Class A basic helix-loop-helix protein 27) (bHLHa27) (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) | Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (PubMed:9931445). {ECO:0000250|UniProtKB:Q64279, ECO:0000269|PubMed:9931445}. |
| P58012 | FOXL2 | S263 | ELM|iPTMNet | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| Q14289 | PTK2B | S866 | Sugiyama | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000171 | 3.767 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.000492 | 3.308 |
| R-HSA-428540 | Activation of RAC1 | 0.000739 | 3.131 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.000919 | 3.037 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.001153 | 2.938 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.001081 | 2.966 |
| R-HSA-162582 | Signal Transduction | 0.001560 | 2.807 |
| R-HSA-8982491 | Glycogen metabolism | 0.002254 | 2.647 |
| R-HSA-392517 | Rap1 signalling | 0.002808 | 2.552 |
| R-HSA-74713 | IRS activation | 0.003051 | 2.516 |
| R-HSA-112412 | SOS-mediated signalling | 0.006087 | 2.216 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.006087 | 2.216 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.007310 | 2.136 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.007310 | 2.136 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.003939 | 2.405 |
| R-HSA-112399 | IRS-mediated signalling | 0.007036 | 2.153 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.006819 | 2.166 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.004968 | 2.304 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.006087 | 2.216 |
| R-HSA-109704 | PI3K Cascade | 0.004744 | 2.324 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.006087 | 2.216 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.006671 | 2.176 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.006772 | 2.169 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.004751 | 2.323 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.007310 | 2.136 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.008626 | 2.064 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.008635 | 2.064 |
| R-HSA-198203 | PI3K/AKT activation | 0.010058 | 1.997 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.009961 | 2.002 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.009961 | 2.002 |
| R-HSA-74749 | Signal attenuation | 0.010058 | 1.997 |
| R-HSA-2586552 | Signaling by Leptin | 0.010058 | 1.997 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.010434 | 1.982 |
| R-HSA-9733709 | Cardiogenesis | 0.010633 | 1.973 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 0.011423 | 1.942 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.013018 | 1.885 |
| R-HSA-166520 | Signaling by NTRKs | 0.012943 | 1.888 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.013192 | 1.880 |
| R-HSA-8853659 | RET signaling | 0.013788 | 1.861 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.014747 | 1.831 |
| R-HSA-170968 | Frs2-mediated activation | 0.016693 | 1.777 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.017940 | 1.746 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.018402 | 1.735 |
| R-HSA-169893 | Prolonged ERK activation events | 0.022594 | 1.646 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.022637 | 1.645 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.024726 | 1.607 |
| R-HSA-5620924 | Intraflagellar transport | 0.027358 | 1.563 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.026946 | 1.570 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.026936 | 1.570 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.027371 | 1.563 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.029900 | 1.524 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.030895 | 1.510 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.030650 | 1.514 |
| R-HSA-422475 | Axon guidance | 0.031345 | 1.504 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.032817 | 1.484 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 0.033882 | 1.470 |
| R-HSA-1632852 | Macroautophagy | 0.036723 | 1.435 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.038997 | 1.409 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.044400 | 1.353 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.042320 | 1.373 |
| R-HSA-9675108 | Nervous system development | 0.046811 | 1.330 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.044442 | 1.352 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.066621 | 1.176 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 0.077287 | 1.112 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.077287 | 1.112 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.087832 | 1.056 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.098257 | 1.008 |
| R-HSA-5579026 | Defective CYP11A1 causes AICSR | 0.098257 | 1.008 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 0.098257 | 1.008 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.108564 | 0.964 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.128826 | 0.890 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.128826 | 0.890 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.138785 | 0.858 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.148631 | 0.828 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.148631 | 0.828 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.148631 | 0.828 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.158365 | 0.800 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.167988 | 0.775 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.167988 | 0.775 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.167988 | 0.775 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.167988 | 0.775 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.167988 | 0.775 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.167988 | 0.775 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.196205 | 0.707 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.196205 | 0.707 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.196205 | 0.707 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.196205 | 0.707 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.214486 | 0.669 |
| R-HSA-4641257 | Degradation of AXIN | 0.091668 | 1.038 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.091668 | 1.038 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.241134 | 0.618 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.052740 | 1.278 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.249816 | 0.602 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.249816 | 0.602 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.249816 | 0.602 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.249816 | 0.602 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.128444 | 0.891 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.128444 | 0.891 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.128444 | 0.891 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.299869 | 0.523 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.331378 | 0.480 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.331378 | 0.480 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.092780 | 1.033 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.241134 | 0.618 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.109641 | 0.960 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.249816 | 0.602 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.275272 | 0.560 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.299869 | 0.523 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.315804 | 0.501 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.109641 | 0.960 |
| R-HSA-203615 | eNOS activation | 0.376016 | 0.425 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.128444 | 0.891 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.266884 | 0.574 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.275272 | 0.560 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.299869 | 0.523 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.323636 | 0.490 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.167988 | 0.775 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.055878 | 1.253 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.167988 | 0.775 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.323636 | 0.490 |
| R-HSA-6798695 | Neutrophil degranulation | 0.311408 | 0.507 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.368788 | 0.433 |
| R-HSA-165158 | Activation of AKT2 | 0.077287 | 1.112 |
| R-HSA-5673000 | RAF activation | 0.081351 | 1.090 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.361476 | 0.442 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.361476 | 0.442 |
| R-HSA-202424 | Downstream TCR signaling | 0.314780 | 0.502 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.307882 | 0.512 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.148631 | 0.828 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.163920 | 0.785 |
| R-HSA-4641258 | Degradation of DVL | 0.091668 | 1.038 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.105975 | 0.975 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.331378 | 0.480 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.339032 | 0.470 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.383162 | 0.417 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.071428 | 1.146 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.376016 | 0.425 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.266884 | 0.574 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.115855 | 0.936 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.383162 | 0.417 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.232353 | 0.634 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.055832 | 1.253 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 0.077287 | 1.112 |
| R-HSA-2395516 | Electron transport from NADPH to Ferredoxin | 0.108564 | 0.964 |
| R-HSA-4839744 | Signaling by APC mutants | 0.148631 | 0.828 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.158365 | 0.800 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.196205 | 0.707 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.205398 | 0.687 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.275272 | 0.560 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.346600 | 0.460 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.376016 | 0.425 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.186907 | 0.728 |
| R-HSA-190236 | Signaling by FGFR | 0.356476 | 0.448 |
| R-HSA-165159 | MTOR signalling | 0.113340 | 0.946 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.167988 | 0.775 |
| R-HSA-9664420 | Killing mechanisms | 0.205398 | 0.687 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.205398 | 0.687 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.117071 | 0.932 |
| R-HSA-187687 | Signalling to ERKs | 0.084748 | 1.072 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.065052 | 1.187 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.124624 | 0.904 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.232353 | 0.634 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.087832 | 1.056 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.108564 | 0.964 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.196205 | 0.707 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.268295 | 0.571 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.249816 | 0.602 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.167965 | 0.775 |
| R-HSA-3928664 | Ephrin signaling | 0.232353 | 0.634 |
| R-HSA-9939291 | Matriglycan biosynthesis on DAG1 | 0.258399 | 0.588 |
| R-HSA-5617833 | Cilium Assembly | 0.220684 | 0.656 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.058882 | 1.230 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.061940 | 1.208 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.081351 | 1.090 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.087832 | 1.056 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.087832 | 1.056 |
| R-HSA-170984 | ARMS-mediated activation | 0.128826 | 0.890 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.148631 | 0.828 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.158365 | 0.800 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.177501 | 0.751 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.074689 | 1.127 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.249816 | 0.602 |
| R-HSA-420029 | Tight junction interactions | 0.299869 | 0.523 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.315804 | 0.501 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.315804 | 0.501 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.354081 | 0.451 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.383162 | 0.417 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.383162 | 0.417 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.118753 | 0.925 |
| R-HSA-9842663 | Signaling by LTK | 0.167988 | 0.775 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.196205 | 0.707 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.109641 | 0.960 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.062653 | 1.203 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.138785 | 0.858 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.383162 | 0.417 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.203988 | 0.690 |
| R-HSA-381042 | PERK regulates gene expression | 0.383162 | 0.417 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.234433 | 0.630 |
| R-HSA-194138 | Signaling by VEGF | 0.079130 | 1.102 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.067523 | 1.171 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.136164 | 0.866 |
| R-HSA-390696 | Adrenoceptors | 0.118753 | 0.925 |
| R-HSA-444257 | RSK activation | 0.118753 | 0.925 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.128826 | 0.890 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.128826 | 0.890 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.167988 | 0.775 |
| R-HSA-9857492 | Protein lipoylation | 0.196205 | 0.707 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.275272 | 0.560 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.283565 | 0.547 |
| R-HSA-429947 | Deadenylation of mRNA | 0.291764 | 0.535 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.198578 | 0.702 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.088188 | 1.055 |
| R-HSA-8931838 | DAG1 glycosylations | 0.354081 | 0.451 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.138785 | 0.858 |
| R-HSA-195721 | Signaling by WNT | 0.075756 | 1.121 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.099626 | 1.002 |
| R-HSA-9612973 | Autophagy | 0.051584 | 1.287 |
| R-HSA-164944 | Nef and signal transduction | 0.098257 | 1.008 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.138785 | 0.858 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.148631 | 0.828 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.167988 | 0.775 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.167988 | 0.775 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.167988 | 0.775 |
| R-HSA-196843 | Vitamin B2 (riboflavin) metabolism | 0.186907 | 0.728 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.223471 | 0.651 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.249816 | 0.602 |
| R-HSA-9930044 | Nuclear RNA decay | 0.361476 | 0.442 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.361476 | 0.442 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.368788 | 0.433 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.376016 | 0.425 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.376016 | 0.425 |
| R-HSA-169911 | Regulation of Apoptosis | 0.383162 | 0.417 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.335723 | 0.474 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.306600 | 0.513 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.196205 | 0.707 |
| R-HSA-445144 | Signal transduction by L1 | 0.249816 | 0.602 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.368819 | 0.433 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.083964 | 1.076 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.158365 | 0.800 |
| R-HSA-6793080 | rRNA modification in the mitochondrion | 0.177501 | 0.751 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.196205 | 0.707 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.205398 | 0.687 |
| R-HSA-70370 | Galactose catabolism | 0.214486 | 0.669 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.214486 | 0.669 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.223471 | 0.651 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.331378 | 0.480 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.268295 | 0.571 |
| R-HSA-199991 | Membrane Trafficking | 0.149694 | 0.825 |
| R-HSA-373753 | Nephrin family interactions | 0.249816 | 0.602 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.352343 | 0.453 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.118753 | 0.925 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.196205 | 0.707 |
| R-HSA-196783 | Coenzyme A biosynthesis | 0.214486 | 0.669 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.241134 | 0.618 |
| R-HSA-8854214 | TBC/RABGAPs | 0.117071 | 0.932 |
| R-HSA-3295583 | TRP channels | 0.307882 | 0.512 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.074440 | 1.128 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.331378 | 0.480 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.361476 | 0.442 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.356031 | 0.449 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.383162 | 0.417 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.154993 | 0.810 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.077997 | 1.108 |
| R-HSA-446199 | Synthesis of dolichyl-phosphate | 0.291764 | 0.535 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.331378 | 0.480 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.339032 | 0.470 |
| R-HSA-9663891 | Selective autophagy | 0.306361 | 0.514 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.141904 | 0.848 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.167988 | 0.775 |
| R-HSA-5635838 | Activation of SMO | 0.205398 | 0.687 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.354081 | 0.451 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.368788 | 0.433 |
| R-HSA-6807070 | PTEN Regulation | 0.106518 | 0.973 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.148631 | 0.828 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.266884 | 0.574 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.234433 | 0.630 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.118753 | 0.925 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.186907 | 0.728 |
| R-HSA-2028269 | Signaling by Hippo | 0.223471 | 0.651 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.087266 | 1.059 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.226000 | 0.646 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.158056 | 0.801 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.381068 | 0.419 |
| R-HSA-8939211 | ESR-mediated signaling | 0.175427 | 0.756 |
| R-HSA-201556 | Signaling by ALK | 0.098748 | 1.005 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.158056 | 0.801 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.272532 | 0.565 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.307882 | 0.512 |
| R-HSA-1474165 | Reproduction | 0.236415 | 0.626 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.352343 | 0.453 |
| R-HSA-373752 | Netrin-1 signaling | 0.120833 | 0.918 |
| R-HSA-5205647 | Mitophagy | 0.376016 | 0.425 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.266884 | 0.574 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.299869 | 0.523 |
| R-HSA-4086400 | PCP/CE pathway | 0.259819 | 0.585 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.153970 | 0.813 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.230214 | 0.638 |
| R-HSA-2559583 | Cellular Senescence | 0.196953 | 0.706 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.052930 | 1.276 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.299869 | 0.523 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.289470 | 0.538 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.379170 | 0.421 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.335556 | 0.474 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.275272 | 0.560 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.361476 | 0.442 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.241134 | 0.618 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.147224 | 0.832 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.361476 | 0.442 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.348201 | 0.458 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.252582 | 0.598 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.361476 | 0.442 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.257782 | 0.589 |
| R-HSA-264876 | Insulin processing | 0.315804 | 0.501 |
| R-HSA-2424491 | DAP12 signaling | 0.339032 | 0.470 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.095189 | 1.021 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.214486 | 0.669 |
| R-HSA-189200 | Cellular hexose transport | 0.275272 | 0.560 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.339032 | 0.470 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.209211 | 0.679 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.283565 | 0.547 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.196709 | 0.706 |
| R-HSA-3322077 | Glycogen synthesis | 0.249816 | 0.602 |
| R-HSA-1500931 | Cell-Cell communication | 0.343567 | 0.464 |
| R-HSA-354192 | Integrin signaling | 0.361476 | 0.442 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.109059 | 0.962 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.050040 | 1.301 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.264057 | 0.578 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.232353 | 0.634 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.275272 | 0.560 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.304303 | 0.517 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.354081 | 0.451 |
| R-HSA-73887 | Death Receptor Signaling | 0.049559 | 1.305 |
| R-HSA-109581 | Apoptosis | 0.341806 | 0.466 |
| R-HSA-5688426 | Deubiquitination | 0.388722 | 0.410 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.390227 | 0.409 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.390227 | 0.409 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.390227 | 0.409 |
| R-HSA-111933 | Calmodulin induced events | 0.390227 | 0.409 |
| R-HSA-111997 | CaM pathway | 0.390227 | 0.409 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.390227 | 0.409 |
| R-HSA-418346 | Platelet homeostasis | 0.393217 | 0.405 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.397211 | 0.401 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.397211 | 0.401 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.401257 | 0.397 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.404115 | 0.393 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.404115 | 0.393 |
| R-HSA-8875878 | MET promotes cell motility | 0.404115 | 0.393 |
| R-HSA-202403 | TCR signaling | 0.409247 | 0.388 |
| R-HSA-1266738 | Developmental Biology | 0.410224 | 0.387 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.410941 | 0.386 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.410941 | 0.386 |
| R-HSA-69541 | Stabilization of p53 | 0.410941 | 0.386 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.410941 | 0.386 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.417689 | 0.379 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.417689 | 0.379 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.417689 | 0.379 |
| R-HSA-9646399 | Aggrephagy | 0.417689 | 0.379 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.417689 | 0.379 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.417689 | 0.379 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.417689 | 0.379 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.417689 | 0.379 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.417689 | 0.379 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.424360 | 0.372 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.424360 | 0.372 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.424360 | 0.372 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.424360 | 0.372 |
| R-HSA-9607240 | FLT3 Signaling | 0.424360 | 0.372 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.425069 | 0.372 |
| R-HSA-388396 | GPCR downstream signalling | 0.430583 | 0.366 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.430956 | 0.366 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.430956 | 0.366 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.430956 | 0.366 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.430956 | 0.366 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.430956 | 0.366 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.430956 | 0.366 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.430956 | 0.366 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.430956 | 0.366 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.432899 | 0.364 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.437476 | 0.359 |
| R-HSA-111996 | Ca-dependent events | 0.437476 | 0.359 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.437476 | 0.359 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.443921 | 0.353 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.443921 | 0.353 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.444535 | 0.352 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.444535 | 0.352 |
| R-HSA-9609690 | HCMV Early Events | 0.449292 | 0.347 |
| R-HSA-9907900 | Proteasome assembly | 0.450294 | 0.347 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.450294 | 0.347 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.450294 | 0.347 |
| R-HSA-2172127 | DAP12 interactions | 0.450294 | 0.347 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.456593 | 0.340 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.456593 | 0.340 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.456593 | 0.340 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.456593 | 0.340 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.456593 | 0.340 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.456593 | 0.340 |
| R-HSA-9824272 | Somitogenesis | 0.456593 | 0.340 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.456593 | 0.340 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.456593 | 0.340 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.457742 | 0.339 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.462821 | 0.335 |
| R-HSA-9675135 | Diseases of DNA repair | 0.462821 | 0.335 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.462821 | 0.335 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.462821 | 0.335 |
| R-HSA-75153 | Apoptotic execution phase | 0.462821 | 0.335 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.467406 | 0.330 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.468978 | 0.329 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.470032 | 0.328 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.471164 | 0.327 |
| R-HSA-69206 | G1/S Transition | 0.478632 | 0.320 |
| R-HSA-5357801 | Programmed Cell Death | 0.478815 | 0.320 |
| R-HSA-9766229 | Degradation of CDH1 | 0.481082 | 0.318 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.481082 | 0.318 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.481082 | 0.318 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.481082 | 0.318 |
| R-HSA-69481 | G2/M Checkpoints | 0.486036 | 0.313 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.486843 | 0.313 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.487030 | 0.312 |
| R-HSA-9748787 | Azathioprine ADME | 0.487030 | 0.312 |
| R-HSA-912446 | Meiotic recombination | 0.492911 | 0.307 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.492911 | 0.307 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.492911 | 0.307 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.492911 | 0.307 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.492911 | 0.307 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.492911 | 0.307 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.498725 | 0.302 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.498725 | 0.302 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.498725 | 0.302 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.498725 | 0.302 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.499041 | 0.302 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.501898 | 0.299 |
| R-HSA-9843745 | Adipogenesis | 0.504259 | 0.297 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.504472 | 0.297 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.504472 | 0.297 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.504472 | 0.297 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.504472 | 0.297 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.504472 | 0.297 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.510154 | 0.292 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.515771 | 0.288 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.515771 | 0.288 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.521324 | 0.283 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.521324 | 0.283 |
| R-HSA-5578775 | Ion homeostasis | 0.521324 | 0.283 |
| R-HSA-75893 | TNF signaling | 0.521324 | 0.283 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.521324 | 0.283 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.525570 | 0.279 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.526814 | 0.278 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.526814 | 0.278 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.532241 | 0.274 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.532241 | 0.274 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.532241 | 0.274 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.532536 | 0.274 |
| R-HSA-180786 | Extension of Telomeres | 0.537606 | 0.270 |
| R-HSA-9033241 | Peroxisomal protein import | 0.537606 | 0.270 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.537606 | 0.270 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.537606 | 0.270 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.542910 | 0.265 |
| R-HSA-351202 | Metabolism of polyamines | 0.542910 | 0.265 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.542910 | 0.265 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.542910 | 0.265 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.542910 | 0.265 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.542910 | 0.265 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.542910 | 0.265 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.542910 | 0.265 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.548153 | 0.261 |
| R-HSA-112043 | PLC beta mediated events | 0.548153 | 0.261 |
| R-HSA-211976 | Endogenous sterols | 0.548153 | 0.261 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.548153 | 0.261 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.553337 | 0.257 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.553337 | 0.257 |
| R-HSA-1268020 | Mitochondrial protein import | 0.553337 | 0.257 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.556367 | 0.255 |
| R-HSA-372790 | Signaling by GPCR | 0.556693 | 0.254 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.558461 | 0.253 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.558461 | 0.253 |
| R-HSA-373755 | Semaphorin interactions | 0.558461 | 0.253 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.558461 | 0.253 |
| R-HSA-8848021 | Signaling by PTK6 | 0.558461 | 0.253 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.558461 | 0.253 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.559890 | 0.252 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.563017 | 0.249 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.568536 | 0.245 |
| R-HSA-69242 | S Phase | 0.569596 | 0.244 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.573487 | 0.241 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.576103 | 0.239 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.578381 | 0.238 |
| R-HSA-112040 | G-protein mediated events | 0.578381 | 0.238 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.578381 | 0.238 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.578381 | 0.238 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.579330 | 0.237 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.583220 | 0.234 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.583220 | 0.234 |
| R-HSA-9609507 | Protein localization | 0.585730 | 0.232 |
| R-HSA-69306 | DNA Replication | 0.585730 | 0.232 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.588903 | 0.230 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.592732 | 0.227 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.592732 | 0.227 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.597407 | 0.224 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.597407 | 0.224 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.597407 | 0.224 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.597407 | 0.224 |
| R-HSA-8978934 | Metabolism of cofactors | 0.597407 | 0.224 |
| R-HSA-4839726 | Chromatin organization | 0.598755 | 0.223 |
| R-HSA-9609646 | HCMV Infection | 0.601265 | 0.221 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.601415 | 0.221 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.602028 | 0.220 |
| R-HSA-877300 | Interferon gamma signaling | 0.604498 | 0.219 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.606597 | 0.217 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.606597 | 0.217 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.607563 | 0.216 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.611113 | 0.214 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.611113 | 0.214 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.611113 | 0.214 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.611113 | 0.214 |
| R-HSA-380287 | Centrosome maturation | 0.615578 | 0.211 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.615578 | 0.211 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.616113 | 0.210 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.619645 | 0.208 |
| R-HSA-5689603 | UCH proteinases | 0.619992 | 0.208 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.619992 | 0.208 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.619992 | 0.208 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.620979 | 0.207 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.624356 | 0.205 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.628669 | 0.202 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.628669 | 0.202 |
| R-HSA-5619084 | ABC transporter disorders | 0.628669 | 0.202 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.628669 | 0.202 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.632934 | 0.199 |
| R-HSA-416476 | G alpha (q) signalling events | 0.635327 | 0.197 |
| R-HSA-6806834 | Signaling by MET | 0.637149 | 0.196 |
| R-HSA-72306 | tRNA processing | 0.640099 | 0.194 |
| R-HSA-212436 | Generic Transcription Pathway | 0.640685 | 0.193 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.641317 | 0.193 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.642950 | 0.192 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.644682 | 0.191 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.649510 | 0.187 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.649510 | 0.187 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.653536 | 0.185 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.653536 | 0.185 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.654176 | 0.184 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.654176 | 0.184 |
| R-HSA-1500620 | Meiosis | 0.657516 | 0.182 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.657516 | 0.182 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.658396 | 0.182 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.661451 | 0.180 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.661451 | 0.180 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.661451 | 0.180 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.661451 | 0.180 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.665341 | 0.177 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.665341 | 0.177 |
| R-HSA-446728 | Cell junction organization | 0.667327 | 0.176 |
| R-HSA-70268 | Pyruvate metabolism | 0.669187 | 0.174 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.672988 | 0.172 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 0.672988 | 0.172 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.676746 | 0.170 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.680461 | 0.167 |
| R-HSA-69275 | G2/M Transition | 0.683605 | 0.165 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.684344 | 0.165 |
| R-HSA-1280218 | Adaptive Immune System | 0.687046 | 0.163 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.688731 | 0.162 |
| R-HSA-983712 | Ion channel transport | 0.691269 | 0.160 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.692094 | 0.160 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.694901 | 0.158 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.694901 | 0.158 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.705304 | 0.152 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.708693 | 0.150 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.708693 | 0.150 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.708693 | 0.150 |
| R-HSA-157579 | Telomere Maintenance | 0.712042 | 0.147 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.718076 | 0.144 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.718627 | 0.143 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.721864 | 0.142 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.721864 | 0.142 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.721864 | 0.142 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.725063 | 0.140 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.728225 | 0.138 |
| R-HSA-111885 | Opioid Signalling | 0.734442 | 0.134 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.743503 | 0.129 |
| R-HSA-69239 | Synthesis of DNA | 0.746455 | 0.127 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.749373 | 0.125 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.752257 | 0.124 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.752257 | 0.124 |
| R-HSA-68882 | Mitotic Anaphase | 0.755654 | 0.122 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.756206 | 0.121 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.756206 | 0.121 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.757725 | 0.120 |
| R-HSA-8957322 | Metabolism of steroids | 0.757945 | 0.120 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.760713 | 0.119 |
| R-HSA-8951664 | Neddylation | 0.765858 | 0.116 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.766191 | 0.116 |
| R-HSA-373760 | L1CAM interactions | 0.776774 | 0.110 |
| R-HSA-162906 | HIV Infection | 0.777614 | 0.109 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.779345 | 0.108 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.779523 | 0.108 |
| R-HSA-5693538 | Homology Directed Repair | 0.781886 | 0.107 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.783297 | 0.106 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.784398 | 0.105 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.789336 | 0.103 |
| R-HSA-73886 | Chromosome Maintenance | 0.789336 | 0.103 |
| R-HSA-3371556 | Cellular response to heat stress | 0.789336 | 0.103 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.789336 | 0.103 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.790675 | 0.102 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.794162 | 0.100 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.798955 | 0.097 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.801195 | 0.096 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.801195 | 0.096 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.801195 | 0.096 |
| R-HSA-157118 | Signaling by NOTCH | 0.801335 | 0.096 |
| R-HSA-112316 | Neuronal System | 0.815622 | 0.089 |
| R-HSA-5576891 | Cardiac conduction | 0.816689 | 0.088 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.816689 | 0.088 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.818802 | 0.087 |
| R-HSA-9909396 | Circadian clock | 0.818802 | 0.087 |
| R-HSA-421270 | Cell-cell junction organization | 0.819634 | 0.086 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.819656 | 0.086 |
| R-HSA-5173105 | O-linked glycosylation | 0.830982 | 0.080 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.832931 | 0.079 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.834858 | 0.078 |
| R-HSA-74160 | Gene expression (Transcription) | 0.834994 | 0.078 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.836763 | 0.077 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.836763 | 0.077 |
| R-HSA-9664407 | Parasite infection | 0.836763 | 0.077 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.838646 | 0.076 |
| R-HSA-913531 | Interferon Signaling | 0.845178 | 0.073 |
| R-HSA-2262752 | Cellular responses to stress | 0.849479 | 0.071 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.851235 | 0.070 |
| R-HSA-9758941 | Gastrulation | 0.854649 | 0.068 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.859625 | 0.066 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.859625 | 0.066 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.861245 | 0.065 |
| R-HSA-1989781 | PPARA activates gene expression | 0.864431 | 0.063 |
| R-HSA-8953854 | Metabolism of RNA | 0.866030 | 0.062 |
| R-HSA-449147 | Signaling by Interleukins | 0.867367 | 0.062 |
| R-HSA-9610379 | HCMV Late Events | 0.867543 | 0.062 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.867543 | 0.062 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.867543 | 0.062 |
| R-HSA-9711097 | Cellular response to starvation | 0.869073 | 0.061 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.882072 | 0.054 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.887919 | 0.052 |
| R-HSA-418555 | G alpha (s) signalling events | 0.888731 | 0.051 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.890017 | 0.051 |
| R-HSA-5668914 | Diseases of metabolism | 0.890577 | 0.050 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.891288 | 0.050 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.891288 | 0.050 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.892545 | 0.049 |
| R-HSA-9679506 | SARS-CoV Infections | 0.900183 | 0.046 |
| R-HSA-3781865 | Diseases of glycosylation | 0.904344 | 0.044 |
| R-HSA-68877 | Mitotic Prometaphase | 0.913857 | 0.039 |
| R-HSA-9824446 | Viral Infection Pathways | 0.916532 | 0.038 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.916814 | 0.038 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.920600 | 0.036 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.920957 | 0.036 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.922428 | 0.035 |
| R-HSA-1643685 | Disease | 0.923156 | 0.035 |
| R-HSA-1640170 | Cell Cycle | 0.924629 | 0.034 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.926731 | 0.033 |
| R-HSA-397014 | Muscle contraction | 0.931760 | 0.031 |
| R-HSA-9748784 | Drug ADME | 0.936371 | 0.029 |
| R-HSA-418990 | Adherens junctions interactions | 0.936371 | 0.029 |
| R-HSA-72312 | rRNA processing | 0.945959 | 0.024 |
| R-HSA-68886 | M Phase | 0.947125 | 0.024 |
| R-HSA-168249 | Innate Immune System | 0.952238 | 0.021 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.954297 | 0.020 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.954641 | 0.020 |
| R-HSA-597592 | Post-translational protein modification | 0.955612 | 0.020 |
| R-HSA-168256 | Immune System | 0.956539 | 0.019 |
| R-HSA-109582 | Hemostasis | 0.956694 | 0.019 |
| R-HSA-418594 | G alpha (i) signalling events | 0.958553 | 0.018 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.964236 | 0.016 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.966388 | 0.015 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.968434 | 0.014 |
| R-HSA-9658195 | Leishmania infection | 0.969523 | 0.013 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.969523 | 0.013 |
| R-HSA-73894 | DNA Repair | 0.987941 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 0.990992 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.992016 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 0.993460 | 0.003 |
| R-HSA-72766 | Translation | 0.994718 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995175 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 0.996740 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.998267 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.998314 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999983 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK4 |
0.815 | 0.706 | -3 | 0.728 |
RSK2 |
0.813 | 0.695 | -3 | 0.700 |
RSK3 |
0.811 | 0.716 | -3 | 0.696 |
P90RSK |
0.808 | 0.713 | -3 | 0.703 |
SGK1 |
0.805 | 0.711 | -3 | 0.835 |
SRPK2 |
0.804 | 0.616 | -3 | 0.803 |
MAPKAPK2 |
0.802 | 0.577 | -3 | 0.695 |
P70S6K |
0.801 | 0.772 | -3 | 0.722 |
AKT2 |
0.800 | 0.652 | -3 | 0.775 |
PIM2 |
0.797 | 0.726 | -3 | 0.707 |
AKT3 |
0.796 | 0.638 | -3 | 0.830 |
PIM1 |
0.796 | 0.666 | -3 | 0.662 |
MSK1 |
0.796 | 0.568 | -3 | 0.697 |
P70S6KB |
0.796 | 0.702 | -3 | 0.626 |
PRKX |
0.796 | 0.511 | -3 | 0.721 |
SRPK1 |
0.794 | 0.542 | -3 | 0.738 |
PRKD2 |
0.794 | 0.557 | -3 | 0.648 |
MSK2 |
0.794 | 0.603 | -3 | 0.712 |
PIM3 |
0.793 | 0.619 | -3 | 0.574 |
CLK2 |
0.793 | 0.528 | -3 | 0.721 |
PKACB |
0.793 | 0.485 | -2 | 0.706 |
PKACA |
0.790 | 0.500 | -2 | 0.668 |
CRIK |
0.790 | 0.786 | -3 | 0.757 |
MAPKAPK3 |
0.789 | 0.560 | -3 | 0.612 |
SBK |
0.789 | 0.636 | -3 | 0.849 |
SRPK3 |
0.789 | 0.555 | -3 | 0.735 |
PRKD3 |
0.788 | 0.596 | -3 | 0.689 |
NDR2 |
0.786 | 0.420 | -3 | 0.498 |
CLK1 |
0.786 | 0.518 | -3 | 0.691 |
CLK4 |
0.786 | 0.518 | -3 | 0.686 |
CDKL5 |
0.785 | 0.554 | -3 | 0.674 |
SGK3 |
0.785 | 0.600 | -3 | 0.641 |
CDKL1 |
0.785 | 0.646 | -3 | 0.651 |
AKT1 |
0.785 | 0.589 | -3 | 0.738 |
PRKD1 |
0.784 | 0.452 | -3 | 0.551 |
NDR1 |
0.784 | 0.517 | -3 | 0.531 |
PKACG |
0.782 | 0.466 | -2 | 0.758 |
CAMK1D |
0.779 | 0.606 | -3 | 0.720 |
CHK2 |
0.776 | 0.628 | -3 | 0.788 |
LATS2 |
0.775 | 0.336 | -5 | 0.350 |
HIPK4 |
0.775 | 0.404 | 1 | 0.733 |
CAMK1A |
0.774 | 0.592 | -3 | 0.760 |
MYLK4 |
0.774 | 0.478 | -2 | 0.795 |
AMPKA2 |
0.773 | 0.488 | -3 | 0.551 |
NUAK2 |
0.772 | 0.488 | -3 | 0.554 |
DYRK3 |
0.772 | 0.470 | 1 | 0.672 |
MAPKAPK5 |
0.771 | 0.559 | -3 | 0.683 |
CLK3 |
0.771 | 0.340 | 1 | 0.775 |
CAMK1B |
0.771 | 0.566 | -3 | 0.505 |
SIK |
0.771 | 0.486 | -3 | 0.616 |
PKG2 |
0.771 | 0.389 | -2 | 0.708 |
PKN3 |
0.770 | 0.468 | -3 | 0.544 |
BRSK1 |
0.770 | 0.467 | -3 | 0.599 |
AURC |
0.768 | 0.264 | -2 | 0.697 |
AMPKA1 |
0.767 | 0.437 | -3 | 0.491 |
DYRK1A |
0.766 | 0.451 | 1 | 0.681 |
ICK |
0.766 | 0.481 | -3 | 0.589 |
CAMK1G |
0.766 | 0.547 | -3 | 0.661 |
SKMLCK |
0.765 | 0.359 | -2 | 0.861 |
CAMK2A |
0.765 | 0.396 | 2 | 0.826 |
HIPK1 |
0.765 | 0.405 | 1 | 0.662 |
CAMK2D |
0.764 | 0.352 | -3 | 0.476 |
MRCKB |
0.763 | 0.563 | -3 | 0.670 |
DYRK2 |
0.763 | 0.308 | 1 | 0.647 |
CAMK4 |
0.763 | 0.409 | -3 | 0.506 |
CAMLCK |
0.762 | 0.482 | -2 | 0.834 |
MELK |
0.762 | 0.481 | -3 | 0.563 |
PAK1 |
0.762 | 0.348 | -2 | 0.789 |
AURB |
0.762 | 0.285 | -2 | 0.688 |
NUAK1 |
0.760 | 0.429 | -3 | 0.603 |
PKN2 |
0.760 | 0.402 | -3 | 0.487 |
HIPK2 |
0.760 | 0.312 | 1 | 0.552 |
MRCKA |
0.759 | 0.557 | -3 | 0.639 |
DAPK2 |
0.759 | 0.521 | -3 | 0.473 |
QSK |
0.759 | 0.357 | 4 | 0.813 |
DCAMKL1 |
0.759 | 0.509 | -3 | 0.602 |
PAK3 |
0.758 | 0.348 | -2 | 0.785 |
CAMK2B |
0.758 | 0.329 | 2 | 0.815 |
DYRK1B |
0.757 | 0.331 | 1 | 0.591 |
CDC7 |
0.757 | 0.138 | 1 | 0.862 |
DYRK4 |
0.756 | 0.277 | 1 | 0.567 |
AURA |
0.756 | 0.255 | -2 | 0.662 |
DAPK1 |
0.756 | 0.527 | -3 | 0.648 |
DAPK3 |
0.755 | 0.538 | -3 | 0.615 |
PKG1 |
0.755 | 0.424 | -2 | 0.644 |
BRSK2 |
0.755 | 0.348 | -3 | 0.513 |
PKN1 |
0.755 | 0.498 | -3 | 0.696 |
HIPK3 |
0.754 | 0.379 | 1 | 0.679 |
TSSK1 |
0.754 | 0.306 | -3 | 0.474 |
MAK |
0.753 | 0.409 | -2 | 0.696 |
DMPK1 |
0.753 | 0.552 | -3 | 0.652 |
SMMLCK |
0.753 | 0.518 | -3 | 0.575 |
MOK |
0.752 | 0.483 | 1 | 0.693 |
WNK1 |
0.752 | 0.263 | -2 | 0.855 |
PAK2 |
0.751 | 0.338 | -2 | 0.770 |
PKCD |
0.751 | 0.329 | 2 | 0.743 |
ROCK2 |
0.751 | 0.545 | -3 | 0.603 |
COT |
0.751 | 0.040 | 2 | 0.848 |
LATS1 |
0.749 | 0.330 | -3 | 0.467 |
MARK4 |
0.749 | 0.201 | 4 | 0.837 |
PHKG1 |
0.748 | 0.352 | -3 | 0.524 |
MNK2 |
0.748 | 0.222 | -2 | 0.785 |
PAK6 |
0.748 | 0.213 | -2 | 0.716 |
CHK1 |
0.746 | 0.275 | -3 | 0.460 |
NIK |
0.746 | 0.417 | -3 | 0.394 |
ROCK1 |
0.746 | 0.552 | -3 | 0.643 |
MOS |
0.746 | 0.092 | 1 | 0.871 |
TSSK2 |
0.746 | 0.229 | -5 | 0.324 |
MNK1 |
0.746 | 0.258 | -2 | 0.794 |
QIK |
0.746 | 0.305 | -3 | 0.458 |
NIM1 |
0.745 | 0.263 | 3 | 0.769 |
IKKB |
0.745 | 0.036 | -2 | 0.692 |
DCAMKL2 |
0.743 | 0.383 | -3 | 0.570 |
RAF1 |
0.743 | 0.127 | 1 | 0.836 |
NLK |
0.742 | 0.126 | 1 | 0.781 |
MST4 |
0.742 | 0.167 | 2 | 0.818 |
PAK5 |
0.741 | 0.264 | -2 | 0.651 |
PRPK |
0.741 | 0.023 | -1 | 0.896 |
MARK3 |
0.741 | 0.227 | 4 | 0.766 |
PKCB |
0.740 | 0.269 | 2 | 0.678 |
MTOR |
0.740 | 0.001 | 1 | 0.762 |
ATR |
0.739 | 0.065 | 1 | 0.801 |
PKCA |
0.739 | 0.248 | 2 | 0.675 |
WNK3 |
0.739 | 0.177 | 1 | 0.810 |
TGFBR2 |
0.738 | 0.073 | -2 | 0.727 |
MARK2 |
0.738 | 0.212 | 4 | 0.751 |
MARK1 |
0.738 | 0.253 | 4 | 0.788 |
RIPK1 |
0.738 | 0.191 | 1 | 0.808 |
PKCG |
0.738 | 0.256 | 2 | 0.682 |
PASK |
0.737 | 0.397 | -3 | 0.513 |
GCN2 |
0.737 | -0.035 | 2 | 0.796 |
PAK4 |
0.737 | 0.248 | -2 | 0.656 |
PKCT |
0.737 | 0.350 | 2 | 0.677 |
CAMK2G |
0.736 | 0.020 | 2 | 0.822 |
PKCH |
0.736 | 0.293 | 2 | 0.670 |
SNRK |
0.736 | 0.295 | 2 | 0.661 |
PHKG2 |
0.736 | 0.346 | -3 | 0.538 |
PKCE |
0.736 | 0.358 | 2 | 0.667 |
ERK5 |
0.735 | 0.043 | 1 | 0.795 |
GRK1 |
0.735 | 0.033 | -2 | 0.792 |
HUNK |
0.735 | 0.071 | 2 | 0.814 |
RIPK3 |
0.734 | 0.058 | 3 | 0.745 |
TBK1 |
0.734 | -0.024 | 1 | 0.750 |
PDHK4 |
0.734 | -0.117 | 1 | 0.835 |
IKKE |
0.731 | -0.048 | 1 | 0.750 |
BMPR2 |
0.731 | -0.097 | -2 | 0.810 |
PDHK1 |
0.730 | -0.086 | 1 | 0.833 |
SSTK |
0.730 | 0.235 | 4 | 0.806 |
GRK6 |
0.730 | 0.034 | 1 | 0.829 |
BCKDK |
0.729 | -0.032 | -1 | 0.835 |
DSTYK |
0.729 | -0.101 | 2 | 0.863 |
ULK2 |
0.728 | -0.083 | 2 | 0.765 |
KIS |
0.728 | -0.008 | 1 | 0.643 |
MASTL |
0.728 | 0.026 | -2 | 0.754 |
ATM |
0.727 | 0.040 | 1 | 0.750 |
GRK5 |
0.726 | -0.073 | -3 | 0.229 |
PKCZ |
0.726 | 0.190 | 2 | 0.730 |
FAM20C |
0.725 | 0.041 | 2 | 0.677 |
CK1E |
0.725 | -0.026 | -3 | 0.134 |
IKKA |
0.725 | -0.077 | -2 | 0.670 |
WNK4 |
0.724 | 0.244 | -2 | 0.836 |
PKCI |
0.724 | 0.266 | 2 | 0.694 |
CDK10 |
0.724 | 0.183 | 1 | 0.559 |
CDK7 |
0.724 | 0.049 | 1 | 0.611 |
BMPR1B |
0.724 | 0.025 | 1 | 0.805 |
DLK |
0.723 | 0.100 | 1 | 0.824 |
GRK4 |
0.722 | -0.069 | -2 | 0.796 |
NEK7 |
0.722 | -0.126 | -3 | 0.218 |
TTBK2 |
0.721 | -0.004 | 2 | 0.671 |
DRAK1 |
0.721 | 0.155 | 1 | 0.737 |
ULK1 |
0.720 | -0.109 | -3 | 0.192 |
DNAPK |
0.720 | 0.049 | 1 | 0.684 |
MLK1 |
0.719 | -0.076 | 2 | 0.770 |
CK1A2 |
0.719 | -0.026 | -3 | 0.129 |
GRK7 |
0.719 | 0.051 | 1 | 0.745 |
CK1D |
0.719 | -0.036 | -3 | 0.106 |
IRE1 |
0.718 | 0.048 | 1 | 0.769 |
CHAK2 |
0.718 | -0.041 | -1 | 0.870 |
TGFBR1 |
0.717 | -0.019 | -2 | 0.739 |
NEK9 |
0.717 | -0.082 | 2 | 0.797 |
ALK4 |
0.717 | -0.005 | -2 | 0.766 |
ANKRD3 |
0.716 | 0.005 | 1 | 0.856 |
PKR |
0.716 | 0.106 | 1 | 0.815 |
NEK6 |
0.716 | -0.135 | -2 | 0.776 |
ALK2 |
0.715 | 0.011 | -2 | 0.754 |
IRE2 |
0.714 | 0.071 | 2 | 0.700 |
PDK1 |
0.714 | 0.278 | 1 | 0.804 |
MLK2 |
0.714 | -0.076 | 2 | 0.783 |
NEK2 |
0.713 | -0.029 | 2 | 0.766 |
MEK1 |
0.713 | -0.009 | 2 | 0.837 |
JNK2 |
0.713 | 0.025 | 1 | 0.555 |
CK1G1 |
0.713 | -0.057 | -3 | 0.121 |
CDK8 |
0.712 | -0.037 | 1 | 0.609 |
SMG1 |
0.712 | -0.039 | 1 | 0.747 |
BUB1 |
0.712 | 0.151 | -5 | 0.353 |
CDK14 |
0.712 | 0.101 | 1 | 0.574 |
PRP4 |
0.710 | -0.016 | -3 | 0.204 |
CDK9 |
0.710 | 0.030 | 1 | 0.593 |
CDK19 |
0.710 | -0.028 | 1 | 0.568 |
ACVR2B |
0.710 | -0.042 | -2 | 0.725 |
VRK2 |
0.709 | -0.029 | 1 | 0.855 |
JNK3 |
0.709 | 0.005 | 1 | 0.594 |
PLK1 |
0.709 | -0.047 | -2 | 0.705 |
MPSK1 |
0.708 | 0.071 | 1 | 0.746 |
ACVR2A |
0.708 | -0.045 | -2 | 0.709 |
IRAK4 |
0.707 | 0.094 | 1 | 0.799 |
P38A |
0.707 | 0.004 | 1 | 0.656 |
BMPR1A |
0.707 | 0.005 | 1 | 0.796 |
CDK18 |
0.707 | 0.005 | 1 | 0.532 |
MST3 |
0.706 | 0.092 | 2 | 0.796 |
YSK4 |
0.706 | -0.065 | 1 | 0.775 |
PBK |
0.706 | 0.174 | 1 | 0.758 |
CHAK1 |
0.706 | -0.008 | 2 | 0.746 |
GRK2 |
0.706 | -0.022 | -2 | 0.684 |
BRAF |
0.705 | 0.042 | -4 | 0.772 |
PLK3 |
0.705 | -0.052 | 2 | 0.797 |
CDK12 |
0.705 | 0.018 | 1 | 0.556 |
CDK13 |
0.704 | -0.015 | 1 | 0.583 |
MEK5 |
0.704 | 0.034 | 2 | 0.808 |
PLK4 |
0.703 | -0.026 | 2 | 0.624 |
PERK |
0.703 | -0.046 | -2 | 0.768 |
IRAK1 |
0.702 | 0.017 | -1 | 0.828 |
MLK3 |
0.701 | -0.076 | 2 | 0.691 |
MEKK3 |
0.701 | -0.044 | 1 | 0.798 |
GRK3 |
0.700 | -0.026 | -2 | 0.656 |
GAK |
0.700 | 0.081 | 1 | 0.817 |
P38B |
0.700 | -0.015 | 1 | 0.587 |
TLK2 |
0.700 | -0.098 | 1 | 0.771 |
LKB1 |
0.699 | 0.004 | -3 | 0.231 |
MLK4 |
0.699 | -0.078 | 2 | 0.685 |
HRI |
0.698 | -0.060 | -2 | 0.771 |
TAO3 |
0.698 | 0.041 | 1 | 0.781 |
MEKK1 |
0.698 | -0.065 | 1 | 0.819 |
P38G |
0.697 | -0.006 | 1 | 0.475 |
CDK5 |
0.696 | -0.013 | 1 | 0.624 |
CDK17 |
0.696 | -0.008 | 1 | 0.472 |
ZAK |
0.696 | -0.048 | 1 | 0.799 |
NEK5 |
0.696 | -0.067 | 1 | 0.821 |
TTBK1 |
0.696 | -0.050 | 2 | 0.596 |
TLK1 |
0.696 | -0.035 | -2 | 0.769 |
HPK1 |
0.695 | 0.117 | 1 | 0.760 |
ERK2 |
0.695 | -0.017 | 1 | 0.610 |
MEKK6 |
0.695 | 0.099 | 1 | 0.811 |
ERK1 |
0.695 | -0.028 | 1 | 0.574 |
LOK |
0.695 | 0.137 | -2 | 0.723 |
NEK11 |
0.695 | -0.007 | 1 | 0.786 |
CDK1 |
0.695 | -0.028 | 1 | 0.553 |
GSK3B |
0.694 | 0.012 | 4 | 0.442 |
MEKK2 |
0.694 | -0.060 | 2 | 0.772 |
GCK |
0.692 | 0.065 | 1 | 0.772 |
TAO2 |
0.692 | 0.054 | 2 | 0.802 |
PINK1 |
0.692 | -0.134 | 1 | 0.763 |
CAMKK2 |
0.691 | -0.028 | -2 | 0.696 |
CK2A2 |
0.691 | 0.017 | 1 | 0.703 |
LRRK2 |
0.691 | 0.143 | 2 | 0.812 |
NEK8 |
0.690 | 0.007 | 2 | 0.774 |
GSK3A |
0.690 | 0.007 | 4 | 0.450 |
TAK1 |
0.689 | 0.042 | 1 | 0.810 |
CAMKK1 |
0.688 | -0.095 | -2 | 0.699 |
KHS2 |
0.688 | 0.116 | 1 | 0.765 |
CDK4 |
0.688 | 0.071 | 1 | 0.537 |
NEK4 |
0.687 | -0.017 | 1 | 0.784 |
MAP3K15 |
0.687 | 0.003 | 1 | 0.783 |
KHS1 |
0.687 | 0.087 | 1 | 0.768 |
CDK2 |
0.687 | -0.047 | 1 | 0.635 |
RIPK2 |
0.686 | 0.013 | 1 | 0.759 |
P38D |
0.686 | -0.028 | 1 | 0.506 |
CK1A |
0.685 | -0.064 | -3 | 0.074 |
NEK1 |
0.685 | -0.017 | 1 | 0.802 |
MINK |
0.684 | 0.002 | 1 | 0.785 |
CDK16 |
0.684 | -0.012 | 1 | 0.491 |
TNIK |
0.684 | 0.029 | 3 | 0.834 |
ERK7 |
0.684 | -0.006 | 2 | 0.489 |
SLK |
0.684 | 0.033 | -2 | 0.658 |
STK33 |
0.683 | 0.006 | 2 | 0.617 |
CDK3 |
0.683 | -0.011 | 1 | 0.496 |
JNK1 |
0.683 | -0.015 | 1 | 0.534 |
HGK |
0.682 | -0.007 | 3 | 0.836 |
PLK2 |
0.682 | -0.073 | -3 | 0.167 |
CK2A1 |
0.682 | 0.009 | 1 | 0.678 |
NEK3 |
0.681 | 0.023 | 1 | 0.788 |
YANK3 |
0.681 | 0.033 | 2 | 0.418 |
VRK1 |
0.681 | 0.015 | 2 | 0.795 |
EEF2K |
0.680 | -0.023 | 3 | 0.799 |
HASPIN |
0.679 | 0.086 | -1 | 0.720 |
YSK1 |
0.678 | 0.033 | 2 | 0.762 |
MEK2 |
0.677 | -0.085 | 2 | 0.792 |
CDK6 |
0.675 | -0.002 | 1 | 0.562 |
MST2 |
0.675 | -0.137 | 1 | 0.800 |
BIKE |
0.674 | 0.048 | 1 | 0.699 |
PDHK3_TYR |
0.673 | 0.083 | 4 | 0.889 |
LIMK2_TYR |
0.670 | 0.205 | -3 | 0.311 |
MST1 |
0.670 | -0.082 | 1 | 0.780 |
MAP2K4_TYR |
0.668 | 0.104 | -1 | 0.905 |
PKMYT1_TYR |
0.667 | 0.124 | 3 | 0.846 |
TESK1_TYR |
0.667 | 0.130 | 3 | 0.876 |
ALPHAK3 |
0.667 | 0.008 | -1 | 0.787 |
TTK |
0.666 | -0.014 | -2 | 0.739 |
CK1G3 |
0.664 | -0.071 | -3 | 0.062 |
MAP2K7_TYR |
0.664 | 0.052 | 2 | 0.853 |
TAO1 |
0.663 | 0.031 | 1 | 0.734 |
ASK1 |
0.663 | -0.032 | 1 | 0.772 |
EPHA6 |
0.663 | 0.101 | -1 | 0.854 |
PINK1_TYR |
0.663 | 0.190 | 1 | 0.819 |
MAP2K6_TYR |
0.663 | 0.012 | -1 | 0.905 |
TNK2 |
0.661 | 0.109 | 3 | 0.764 |
AAK1 |
0.661 | 0.056 | 1 | 0.595 |
RET |
0.661 | 0.096 | 1 | 0.809 |
PDHK4_TYR |
0.661 | -0.026 | 2 | 0.894 |
MYO3B |
0.661 | -0.012 | 2 | 0.773 |
OSR1 |
0.660 | -0.072 | 2 | 0.780 |
DDR1 |
0.660 | 0.121 | 4 | 0.802 |
BMPR2_TYR |
0.659 | -0.010 | -1 | 0.886 |
PDHK1_TYR |
0.658 | -0.039 | -1 | 0.901 |
EPHB4 |
0.658 | 0.035 | -1 | 0.844 |
LIMK1_TYR |
0.656 | 0.075 | 2 | 0.823 |
MST1R |
0.654 | 0.026 | 3 | 0.810 |
TYRO3 |
0.654 | 0.002 | 3 | 0.791 |
ABL2 |
0.652 | 0.013 | -1 | 0.839 |
SRMS |
0.651 | -0.014 | 1 | 0.864 |
MYO3A |
0.651 | -0.045 | 1 | 0.759 |
ROS1 |
0.651 | 0.002 | 3 | 0.765 |
TYK2 |
0.651 | -0.058 | 1 | 0.816 |
ITK |
0.651 | 0.006 | -1 | 0.863 |
DDR2 |
0.650 | 0.166 | 3 | 0.739 |
NEK10_TYR |
0.650 | 0.076 | 1 | 0.696 |
AXL |
0.650 | 0.046 | 3 | 0.787 |
TXK |
0.649 | -0.008 | 1 | 0.838 |
ABL1 |
0.649 | -0.000 | -1 | 0.836 |
EPHA4 |
0.648 | -0.013 | 2 | 0.805 |
FGR |
0.648 | -0.028 | 1 | 0.846 |
FER |
0.648 | -0.056 | 1 | 0.878 |
TNK1 |
0.648 | 0.083 | 3 | 0.768 |
YES1 |
0.648 | -0.022 | -1 | 0.877 |
EPHB3 |
0.647 | -0.010 | -1 | 0.831 |
EPHB1 |
0.647 | -0.027 | 1 | 0.873 |
JAK2 |
0.647 | -0.100 | 1 | 0.819 |
TNNI3K_TYR |
0.646 | 0.032 | 1 | 0.832 |
LCK |
0.646 | -0.018 | -1 | 0.868 |
FGFR2 |
0.646 | 0.017 | 3 | 0.801 |
JAK3 |
0.645 | -0.022 | 1 | 0.801 |
MERTK |
0.645 | -0.004 | 3 | 0.784 |
CSF1R |
0.645 | -0.083 | 3 | 0.789 |
STLK3 |
0.645 | -0.115 | 1 | 0.756 |
EPHB2 |
0.644 | -0.027 | -1 | 0.821 |
INSRR |
0.644 | 0.003 | 3 | 0.748 |
BLK |
0.644 | -0.005 | -1 | 0.856 |
TEK |
0.644 | 0.009 | 3 | 0.729 |
EPHA1 |
0.644 | 0.043 | 3 | 0.769 |
FLT3 |
0.644 | 0.023 | 3 | 0.783 |
CK1G2 |
0.643 | -0.059 | -3 | 0.088 |
PDGFRB |
0.643 | 0.020 | 3 | 0.800 |
HCK |
0.643 | -0.078 | -1 | 0.871 |
BMX |
0.642 | -0.003 | -1 | 0.769 |
EPHA7 |
0.641 | -0.002 | 2 | 0.797 |
KDR |
0.641 | 0.017 | 3 | 0.757 |
BTK |
0.640 | -0.063 | -1 | 0.844 |
LTK |
0.639 | 0.030 | 3 | 0.740 |
TEC |
0.639 | -0.016 | -1 | 0.795 |
JAK1 |
0.639 | -0.041 | 1 | 0.766 |
FGFR1 |
0.639 | -0.022 | 3 | 0.774 |
MET |
0.638 | -0.030 | 3 | 0.789 |
KIT |
0.637 | -0.085 | 3 | 0.790 |
YANK2 |
0.637 | -0.033 | 2 | 0.435 |
PTK2B |
0.637 | 0.008 | -1 | 0.821 |
ALK |
0.636 | -0.001 | 3 | 0.718 |
EPHA3 |
0.636 | -0.040 | 2 | 0.771 |
FYN |
0.635 | -0.036 | -1 | 0.841 |
WEE1_TYR |
0.634 | -0.024 | -1 | 0.809 |
PDGFRA |
0.634 | -0.045 | 3 | 0.793 |
EPHA5 |
0.632 | -0.020 | 2 | 0.794 |
FGFR3 |
0.632 | -0.030 | 3 | 0.772 |
PTK6 |
0.632 | -0.080 | -1 | 0.801 |
NTRK1 |
0.631 | -0.083 | -1 | 0.839 |
FLT1 |
0.628 | -0.067 | -1 | 0.831 |
LYN |
0.628 | -0.090 | 3 | 0.706 |
FRK |
0.628 | -0.077 | -1 | 0.864 |
NTRK2 |
0.628 | -0.087 | 3 | 0.765 |
ERBB2 |
0.628 | -0.087 | 1 | 0.755 |
INSR |
0.626 | -0.062 | 3 | 0.720 |
FLT4 |
0.625 | -0.050 | 3 | 0.749 |
EPHA8 |
0.625 | -0.054 | -1 | 0.806 |
MATK |
0.624 | -0.060 | -1 | 0.747 |
SRC |
0.624 | -0.074 | -1 | 0.833 |
NTRK3 |
0.623 | -0.094 | -1 | 0.787 |
PTK2 |
0.623 | -0.019 | -1 | 0.783 |
CSK |
0.622 | -0.085 | 2 | 0.790 |
SYK |
0.620 | -0.045 | -1 | 0.767 |
EGFR |
0.619 | -0.079 | 1 | 0.675 |
EPHA2 |
0.619 | -0.049 | -1 | 0.771 |
FGFR4 |
0.616 | -0.086 | -1 | 0.776 |
IGF1R |
0.611 | -0.067 | 3 | 0.660 |
ERBB4 |
0.609 | -0.061 | 1 | 0.681 |
FES |
0.604 | -0.087 | -1 | 0.746 |
MUSK |
0.604 | -0.098 | 1 | 0.667 |
ZAP70 |
0.599 | -0.053 | -1 | 0.706 |