Motif 324 (n=77)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0C4DFX4 None S2610 ochoa Snf2 related CREBBP activator protein None
O14974 PPP1R12A S680 ochoa|psp Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
O15211 RGL2 S750 ochoa Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}.
O60292 SIPA1L3 S1544 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O75376 NCOR1 S2105 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
P15822 HIVEP1 S1143 ochoa Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P23588 EIF4B S430 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P28290 ITPRID2 S752 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P38159 RBMX Y285 ochoa RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}.
P50402 EMD Y34 psp Emerin Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}.
P51114 FXR1 S432 ochoa RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}.
P51114 FXR1 S496 ochoa RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}.
P51116 FXR2 T610 ochoa RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P51116 FXR2 S622 ochoa RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P52799 EFNB2 S270 ochoa Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}.
P52926 HMGA2 S44 ochoa High mobility group protein HMGI-C (High mobility group AT-hook protein 2) Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}.
Q07955 SRSF1 S223 psp Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.
Q10570 CPSF1 S765 ochoa Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}.
Q13242 SRSF9 S189 ochoa Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}.
Q13243 SRSF5 S86 psp Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Q13563 PKD2 S76 ochoa|psp Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}.
Q14004 CDK13 S385 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14004 CDK13 S397 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q16555 DPYSL2 S507 ochoa Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}.
Q3KQU3 MAP7D1 S368 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q5T200 ZC3H13 S1264 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q68DK2 ZFYVE26 S1777 ochoa Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}.
Q6ICG6 KIAA0930 S276 ochoa Uncharacterized protein KIAA0930 None
Q6ICG6 KIAA0930 S289 ochoa Uncharacterized protein KIAA0930 None
Q6NYC8 PPP1R18 S209 ochoa Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.
Q6PD62 CTR9 S1087 ochoa RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.
Q6WCQ1 MPRIP S362 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6ZRS2 SRCAP S2787 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q86WB0 ZC3HC1 S344 ochoa|psp Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}.
Q8IYB3 SRRM1 S551 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8N699 MYCT1 S114 ochoa Myc target protein 1 (Myc target in myeloid cells protein 1) May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). {ECO:0000250}.
Q8TF72 SHROOM3 S1021 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8TF76 HASPIN T97 ochoa|psp Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.
Q8WX93 PALLD S1106 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q96E39 RBMXL1 Y285 ochoa RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96JY6 PDLIM2 Y122 ochoa PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}.
Q96T58 SPEN S635 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q96T58 SPEN S725 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99501 GAS2L1 S306 ochoa GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q9BRD0 BUD13 S185 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BRD0 BUD13 S211 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9H8V3 ECT2 S397 ochoa|psp Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}.
Q9HCG8 CWC22 S49 ochoa Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.
Q9HCP0 CSNK1G1 S344 psp Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}.
Q9HD20 ATP13A1 S905 ochoa Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}.
Q9NRL2 BAZ1A S1402 ochoa Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}.
Q9NVW2 RLIM S215 psp E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}.
Q9NWH9 SLTM S999 ochoa SAFB-like transcription modulator (Modulator of estrogen-induced transcription) When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9NXH8 TOR4A S87 ochoa Torsin-4A (Torsin family 4 member A) None
Q9NYV4 CDK12 S288 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9NZM5 NOP53 S29 ochoa Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081). {ECO:0000269|PubMed:15355975, ECO:0000269|PubMed:16971513, ECO:0000269|PubMed:21167305, ECO:0000269|PubMed:21741933, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:24556985, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081, ECO:0000269|PubMed:27829214}.
Q9P206 NHSL3 S327 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9UNF1 MAGED2 S244 ochoa Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}.
Q9UPN3 MACF1 S7236 ochoa Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UQ35 SRRM2 S1830 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1854 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1866 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1878 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1890 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1925 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1972 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1984 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S2020 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S2032 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S2044 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S2090 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2H5 PLEKHA6 S338 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y2H5 PLEKHA6 S461 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y4D8 HECTD4 S1139 ochoa Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.
Q9Y570 PPME1 S27 ochoa Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.
Q32M45 ANO4 S849 Sugiyama Anoctamin-4 (Transmembrane protein 16D) Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). {ECO:0000250|UniProtKB:Q8C5H1}.
Q9Y4K4 MAP4K5 S423 Sugiyama Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.
Download
reactome_id name p -log10_p
R-HSA-72172 mRNA Splicing 0.000002 5.782
R-HSA-72163 mRNA Splicing - Major Pathway 0.000001 5.943
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.000001 5.846
R-HSA-72187 mRNA 3'-end processing 0.000003 5.517
R-HSA-73856 RNA Polymerase II Transcription Termination 0.000006 5.224
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.000021 4.673
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.000234 3.631
R-HSA-8953854 Metabolism of RNA 0.001028 2.988
R-HSA-114608 Platelet degranulation 0.015445 1.811
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.028893 1.539
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.056965 1.244
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.074103 1.130
R-HSA-3928664 Ephrin signaling 0.080872 1.092
R-HSA-429947 Deadenylation of mRNA 0.104184 0.982
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.029646 1.528
R-HSA-390522 Striated Muscle Contraction 0.136481 0.865
R-HSA-72165 mRNA Splicing - Minor Pathway 0.179781 0.745
R-HSA-72649 Translation initiation complex formation 0.203558 0.691
R-HSA-72702 Ribosomal scanning and start codon recognition 0.209396 0.679
R-HSA-5620916 VxPx cargo-targeting to cilium 0.087593 1.058
R-HSA-3928662 EPHB-mediated forward signaling 0.173728 0.760
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.087593 1.058
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.155306 0.809
R-HSA-399956 CRMPs in Sema3A signaling 0.063857 1.195
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.182791 0.738
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.060417 1.219
R-HSA-350054 Notch-HLH transcription pathway 0.097583 1.011
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.104184 0.982
R-HSA-112382 Formation of RNA Pol II elongation complex 0.197678 0.704
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.200623 0.698
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.215191 0.667
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.123702 0.908
R-HSA-429914 Deadenylation-dependent mRNA decay 0.218073 0.661
R-HSA-9707616 Heme signaling 0.226657 0.645
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.053500 1.272
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.155306 0.809
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.251857 0.599
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.039926 1.399
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.161491 0.792
R-HSA-9005895 Pervasive developmental disorders 0.056965 1.244
R-HSA-9697154 Disorders of Nervous System Development 0.056965 1.244
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.056965 1.244
R-HSA-9733458 Induction of Cell-Cell Fusion 0.070700 1.151
R-HSA-3214815 HDACs deacetylate histones 0.206482 0.685
R-HSA-1251985 Nuclear signaling by ERBB4 0.158404 0.800
R-HSA-9675151 Disorders of Developmental Biology 0.074103 1.130
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.080872 1.092
R-HSA-2980766 Nuclear Envelope Breakdown 0.212299 0.673
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.094265 1.026
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.017527 1.756
R-HSA-193648 NRAGE signals death through JNK 0.209396 0.679
R-HSA-6784531 tRNA processing in the nucleus 0.226657 0.645
R-HSA-166208 mTORC1-mediated signalling 0.097583 1.011
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.197678 0.704
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.130114 0.886
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.158404 0.800
R-HSA-6802957 Oncogenic MAPK signaling 0.045943 1.338
R-HSA-373755 Semaphorin interactions 0.229498 0.639
R-HSA-9022692 Regulation of MECP2 expression and activity 0.133303 0.875
R-HSA-437239 Recycling pathway of L1 0.182791 0.738
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.185790 0.731
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.209396 0.679
R-HSA-936837 Ion transport by P-type ATPases 0.232328 0.634
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.257347 0.589
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.188778 0.724
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.220945 0.656
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.226657 0.645
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.215191 0.667
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.220945 0.656
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.220945 0.656
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.220945 0.656
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.220945 0.656
R-HSA-983712 Ion channel transport 0.177093 0.752
R-HSA-165159 MTOR signalling 0.167632 0.776
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.226657 0.645
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.133303 0.875
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.220945 0.656
R-HSA-73857 RNA Polymerase II Transcription 0.172173 0.764
R-HSA-69275 G2/M Transition 0.173176 0.762
R-HSA-453274 Mitotic G2-G2/M phases 0.175786 0.755
R-HSA-76002 Platelet activation, signaling and aggregation 0.093339 1.030
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.133266 0.875
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.260076 0.585
R-HSA-1236394 Signaling by ERBB4 0.260076 0.585
R-HSA-8852135 Protein ubiquitination 0.262796 0.580
R-HSA-1980143 Signaling by NOTCH1 0.265507 0.576
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.268207 0.572
R-HSA-383280 Nuclear Receptor transcription pathway 0.270898 0.567
R-HSA-416482 G alpha (12/13) signalling events 0.270898 0.567
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.276250 0.559
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.278911 0.555
R-HSA-9707564 Cytoprotection by HMOX1 0.284205 0.546
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.286838 0.542
R-HSA-74160 Gene expression (Transcription) 0.302854 0.519
R-HSA-8986944 Transcriptional Regulation by MECP2 0.307560 0.512
R-HSA-2682334 EPH-Ephrin signaling 0.312647 0.505
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.312647 0.505
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.325205 0.488
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.327690 0.485
R-HSA-193704 p75 NTR receptor-mediated signalling 0.332632 0.478
R-HSA-1483255 PI Metabolism 0.339978 0.469
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.347244 0.459
R-HSA-5619507 Activation of HOX genes during differentiation 0.347244 0.459
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.354432 0.450
R-HSA-9700206 Signaling by ALK in cancer 0.354432 0.450
R-HSA-1852241 Organelle biogenesis and maintenance 0.354768 0.450
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.356811 0.448
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.356811 0.448
R-HSA-2672351 Stimuli-sensing channels 0.356811 0.448
R-HSA-69278 Cell Cycle, Mitotic 0.364775 0.438
R-HSA-72613 Eukaryotic Translation Initiation 0.380128 0.420
R-HSA-72737 Cap-dependent Translation Initiation 0.380128 0.420
R-HSA-373760 L1CAM interactions 0.380128 0.420
R-HSA-1592230 Mitochondrial biogenesis 0.382413 0.417
R-HSA-68875 Mitotic Prophase 0.389220 0.410
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.395953 0.402
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.402613 0.395
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.402613 0.395
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.402613 0.395
R-HSA-9843745 Adipogenesis 0.417874 0.379
R-HSA-9909396 Circadian clock 0.420023 0.377
R-HSA-9609507 Protein localization 0.467344 0.330
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.469313 0.329
R-HSA-73887 Death Receptor Signaling 0.469313 0.329
R-HSA-1989781 PPARA activates gene expression 0.471275 0.327
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.475177 0.323
R-HSA-9006936 Signaling by TGFB family members 0.480977 0.318
R-HSA-72306 tRNA processing 0.501711 0.300
R-HSA-1640170 Cell Cycle 0.503080 0.298
R-HSA-2559583 Cellular Senescence 0.519852 0.284
R-HSA-3700989 Transcriptional Regulation by TP53 0.534975 0.272
R-HSA-5617833 Cilium Assembly 0.537344 0.270
R-HSA-9609690 HCMV Early Events 0.547536 0.262
R-HSA-428157 Sphingolipid metabolism 0.555861 0.255
R-HSA-109582 Hemostasis 0.570943 0.243
R-HSA-397014 Muscle contraction 0.575231 0.240
R-HSA-68882 Mitotic Anaphase 0.581502 0.235
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.583055 0.234
R-HSA-3247509 Chromatin modifying enzymes 0.608610 0.216
R-HSA-157118 Signaling by NOTCH 0.617257 0.210
R-HSA-422475 Axon guidance 0.618602 0.209
R-HSA-4839726 Chromatin organization 0.629876 0.201
R-HSA-9609646 HCMV Infection 0.631253 0.200
R-HSA-9675108 Nervous system development 0.653293 0.185
R-HSA-9711123 Cellular response to chemical stress 0.655188 0.184
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.672743 0.172
R-HSA-5673001 RAF/MAP kinase cascade 0.681188 0.167
R-HSA-1483257 Phospholipid metabolism 0.688255 0.162
R-HSA-5684996 MAPK1/MAPK3 signaling 0.689418 0.162
R-HSA-212165 Epigenetic regulation of gene expression 0.719253 0.143
R-HSA-5683057 MAPK family signaling cascades 0.743395 0.129
R-HSA-9694516 SARS-CoV-2 Infection 0.745312 0.128
R-HSA-9006931 Signaling by Nuclear Receptors 0.758343 0.120
R-HSA-68886 M Phase 0.775829 0.110
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.776670 0.110
R-HSA-162582 Signal Transduction 0.810765 0.091
R-HSA-72766 Translation 0.812174 0.090
R-HSA-6798695 Neutrophil degranulation 0.831002 0.080
R-HSA-9679506 SARS-CoV Infections 0.883409 0.054
R-HSA-382551 Transport of small molecules 0.888994 0.051
R-HSA-2262752 Cellular responses to stress 0.900932 0.045
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.906509 0.043
R-HSA-556833 Metabolism of lipids 0.923528 0.035
R-HSA-9824446 Viral Infection Pathways 0.929604 0.032
R-HSA-8953897 Cellular responses to stimuli 0.933525 0.030
R-HSA-212436 Generic Transcription Pathway 0.936239 0.029
R-HSA-1266738 Developmental Biology 0.940530 0.027
R-HSA-388396 GPCR downstream signalling 0.949570 0.022
R-HSA-372790 Signaling by GPCR 0.963409 0.016
R-HSA-1280218 Adaptive Immune System 0.982489 0.008
R-HSA-1643685 Disease 0.985978 0.006
R-HSA-5663205 Infectious disease 0.989432 0.005
R-HSA-168249 Innate Immune System 0.994293 0.002
R-HSA-597592 Post-translational protein modification 0.998498 0.001
R-HSA-392499 Metabolism of proteins 0.999261 0.000
R-HSA-168256 Immune System 0.999824 0.000
R-HSA-1430728 Metabolism 0.999973 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK2CLK2 0.782 0.454 -3 0.873
SRPK1SRPK1 0.782 0.463 -3 0.896
CLK3CLK3 0.780 0.391 1 0.745
HIPK2HIPK2 0.773 0.413 1 0.770
SRPK2SRPK2 0.772 0.432 -3 0.880
HIPK4HIPK4 0.771 0.453 1 0.829
SRPK3SRPK3 0.769 0.419 -3 0.883
DYRK2DYRK2 0.764 0.393 1 0.812
KISKIS 0.764 0.309 1 0.730
CLK4CLK4 0.763 0.404 -3 0.872
HIPK1HIPK1 0.762 0.440 1 0.814
PIM3PIM3 0.761 0.359 -3 0.853
RSK2RSK2 0.761 0.392 -3 0.880
DYRK4DYRK4 0.760 0.366 1 0.755
CLK1CLK1 0.758 0.402 -3 0.854
DYRK3DYRK3 0.755 0.420 1 0.831
PIM1PIM1 0.755 0.375 -3 0.869
COTCOT 0.754 0.183 2 0.803
RSK4RSK4 0.753 0.379 -3 0.863
CDKL1CDKL1 0.753 0.402 -3 0.887
MOSMOS 0.753 0.283 1 0.740
CDKL5CDKL5 0.751 0.342 -3 0.893
P90RSKP90RSK 0.749 0.367 -3 0.886
CDK1CDK1 0.749 0.221 1 0.727
RSK3RSK3 0.748 0.354 -3 0.880
DYRK1BDYRK1B 0.747 0.348 1 0.753
PRKXPRKX 0.746 0.307 -3 0.814
CDC7CDC7 0.743 0.104 1 0.704
ICKICK 0.743 0.343 -3 0.869
CDK10CDK10 0.743 0.294 1 0.726
PKACBPKACB 0.743 0.286 -2 0.466
NDR2NDR2 0.743 0.211 -3 0.808
GRK1GRK1 0.742 0.187 -2 0.722
DYRK1ADYRK1A 0.742 0.374 1 0.755
AURCAURC 0.741 0.195 -2 0.468
MAPKAPK2MAPKAPK2 0.741 0.314 -3 0.849
P70S6KBP70S6KB 0.741 0.329 -3 0.859
PIM2PIM2 0.741 0.387 -3 0.867
NDR1NDR1 0.741 0.256 -3 0.831
CAMK1BCAMK1B 0.741 0.309 -3 0.838
AKT2AKT2 0.740 0.366 -3 0.862
BMPR1BBMPR1B 0.740 0.161 1 0.673
HIPK3HIPK3 0.740 0.385 1 0.762
NLKNLK 0.740 0.219 1 0.770
PRKD2PRKD2 0.739 0.315 -3 0.837
MSK1MSK1 0.738 0.301 -3 0.880
NUAK2NUAK2 0.738 0.256 -3 0.838
CAMK2ACAMK2A 0.736 0.243 2 0.755
MAKMAK 0.735 0.363 -2 0.541
GRK7GRK7 0.735 0.169 1 0.608
PKACGPKACG 0.734 0.227 -2 0.514
MSK2MSK2 0.734 0.294 -3 0.887
MTORMTOR 0.733 0.055 1 0.643
MOKMOK 0.733 0.420 1 0.829
PASKPASK 0.733 0.347 -3 0.831
SKMLCKSKMLCK 0.733 0.217 -2 0.621
PKN2PKN2 0.732 0.224 -3 0.815
CDK3CDK3 0.732 0.181 1 0.691
MAPKAPK3MAPKAPK3 0.732 0.289 -3 0.839
PKN3PKN3 0.731 0.221 -3 0.832
CAMLCKCAMLCK 0.731 0.239 -2 0.616
ATRATR 0.731 0.069 1 0.671
GCN2GCN2 0.730 -0.001 2 0.750
DSTYKDSTYK 0.730 0.031 2 0.836
IKKBIKKB 0.729 0.009 -2 0.547
CAMK1GCAMK1G 0.729 0.320 -3 0.850
CDK7CDK7 0.729 0.180 1 0.741
CDK19CDK19 0.729 0.164 1 0.712
P38GP38G 0.729 0.194 1 0.668
TGFBR2TGFBR2 0.729 0.073 -2 0.683
CDK8CDK8 0.728 0.146 1 0.729
PRKD3PRKD3 0.728 0.312 -3 0.855
CDK18CDK18 0.728 0.189 1 0.706
GRK5GRK5 0.728 0.041 -3 0.691
DAPK2DAPK2 0.727 0.243 -3 0.825
PAK1PAK1 0.727 0.184 -2 0.568
NIKNIK 0.727 0.243 -3 0.788
JNK3JNK3 0.727 0.194 1 0.717
MYLK4MYLK4 0.726 0.244 -2 0.556
JNK2JNK2 0.726 0.207 1 0.696
LATS2LATS2 0.726 0.147 -5 0.617
RAF1RAF1 0.725 0.028 1 0.621
PRPKPRPK 0.725 -0.054 -1 0.675
PKCDPKCD 0.725 0.187 2 0.729
CDK5CDK5 0.725 0.160 1 0.751
MLK3MLK3 0.725 0.084 2 0.720
PKCBPKCB 0.725 0.199 2 0.700
MLK1MLK1 0.725 0.026 2 0.772
PKACAPKACA 0.725 0.260 -2 0.423
PRKD1PRKD1 0.725 0.201 -3 0.837
GSK3AGSK3A 0.725 0.157 4 0.516
CDK13CDK13 0.724 0.157 1 0.723
AURBAURB 0.724 0.154 -2 0.468
AKT3AKT3 0.724 0.358 -3 0.853
GRK6GRK6 0.724 0.049 1 0.658
BMPR2BMPR2 0.724 -0.025 -2 0.678
CDK12CDK12 0.724 0.181 1 0.702
CAMK2BCAMK2B 0.723 0.162 2 0.713
WNK1WNK1 0.723 0.140 -2 0.605
CDK14CDK14 0.723 0.227 1 0.726
PKCGPKCG 0.723 0.184 2 0.717
AURAAURA 0.722 0.118 -2 0.475
ERK1ERK1 0.722 0.175 1 0.684
DLKDLK 0.722 0.103 1 0.632
CHAK2CHAK2 0.722 0.034 -1 0.705
CAMK2GCAMK2G 0.722 -0.011 2 0.739
CDK2CDK2 0.722 0.126 1 0.751
ERK5ERK5 0.721 0.046 1 0.697
P70S6KP70S6K 0.721 0.330 -3 0.861
RIPK3RIPK3 0.721 0.041 3 0.532
PKG2PKG2 0.721 0.185 -2 0.456
GRK4GRK4 0.721 0.048 -2 0.714
CDK17CDK17 0.721 0.173 1 0.672
CDK9CDK9 0.720 0.168 1 0.722
LATS1LATS1 0.720 0.173 -3 0.803
HUNKHUNK 0.720 0.034 2 0.785
P38BP38B 0.719 0.175 1 0.684
PKCAPKCA 0.719 0.165 2 0.689
SGK1SGK1 0.719 0.360 -3 0.850
SGK3SGK3 0.719 0.281 -3 0.853
NEK6NEK6 0.719 -0.025 -2 0.641
AKT1AKT1 0.718 0.301 -3 0.853
MLK4MLK4 0.718 0.053 2 0.695
ACVR2BACVR2B 0.718 0.059 -2 0.674
IRE1IRE1 0.718 0.090 1 0.675
P38AP38A 0.717 0.167 1 0.726
PRP4PRP4 0.717 0.132 -3 0.637
PAK3PAK3 0.717 0.141 -2 0.556
ALK4ALK4 0.717 0.063 -2 0.687
CAMK2DCAMK2D 0.717 0.122 -3 0.806
BMPR1ABMPR1A 0.717 0.084 1 0.657
AMPKA1AMPKA1 0.717 0.155 -3 0.816
GRK2GRK2 0.717 0.052 -2 0.609
ACVR2AACVR2A 0.716 0.042 -2 0.669
P38DP38D 0.716 0.176 1 0.687
AMPKA2AMPKA2 0.716 0.185 -3 0.826
ERK2ERK2 0.716 0.160 1 0.709
MNK1MNK1 0.716 0.140 -2 0.554
MST4MST4 0.715 0.052 2 0.785
MAPKAPK5MAPKAPK5 0.715 0.251 -3 0.866
PKCZPKCZ 0.715 0.149 2 0.724
ALK2ALK2 0.715 0.071 -2 0.696
PKCEPKCE 0.715 0.239 2 0.700
PKCHPKCH 0.715 0.169 2 0.680
PHKG1PHKG1 0.715 0.158 -3 0.818
DRAK1DRAK1 0.715 0.096 1 0.607
PDHK4PDHK4 0.715 -0.186 1 0.661
JNK1JNK1 0.715 0.176 1 0.700
GSK3BGSK3B 0.714 0.115 4 0.518
TGFBR1TGFBR1 0.714 0.047 -2 0.678
CK1ECK1E 0.714 0.075 -3 0.447
PAK2PAK2 0.714 0.136 -2 0.561
CAMK4CAMK4 0.714 0.142 -3 0.802
DCAMKL1DCAMKL1 0.714 0.245 -3 0.826
CDK16CDK16 0.714 0.166 1 0.685
ATMATM 0.713 0.006 1 0.623
TTBK2TTBK2 0.713 0.026 2 0.680
ANKRD3ANKRD3 0.713 0.022 1 0.656
NEK7NEK7 0.713 -0.096 -3 0.683
RIPK1RIPK1 0.712 0.099 1 0.663
IKKEIKKE 0.712 -0.115 1 0.486
BRSK1BRSK1 0.712 0.162 -3 0.838
TBK1TBK1 0.712 -0.122 1 0.492
DAPK1DAPK1 0.711 0.270 -3 0.858
CK1DCK1D 0.711 0.089 -3 0.399
CAMK1DCAMK1D 0.711 0.297 -3 0.829
PLK1PLK1 0.711 -0.007 -2 0.637
PAK6PAK6 0.711 0.134 -2 0.493
GRK3GRK3 0.711 0.056 -2 0.608
CHK2CHK2 0.711 0.335 -3 0.835
DAPK3DAPK3 0.710 0.261 -3 0.847
PKRPKR 0.710 0.122 1 0.693
MLK2MLK2 0.710 -0.015 2 0.763
ULK2ULK2 0.710 -0.141 2 0.705
SBKSBK 0.709 0.361 -3 0.817
PINK1PINK1 0.709 0.039 1 0.765
NUAK1NUAK1 0.709 0.159 -3 0.834
MASTLMASTL 0.709 -0.074 -2 0.598
MARK4MARK4 0.709 -0.002 4 0.706
SMMLCKSMMLCK 0.709 0.240 -3 0.850
IKKAIKKA 0.708 -0.073 -2 0.551
TSSK2TSSK2 0.708 0.056 -5 0.635
MELKMELK 0.708 0.186 -3 0.824
IRE2IRE2 0.708 0.040 2 0.650
TLK2TLK2 0.707 0.019 1 0.617
SIKSIK 0.707 0.170 -3 0.822
MNK2MNK2 0.706 0.085 -2 0.537
CDK4CDK4 0.706 0.192 1 0.700
QSKQSK 0.706 0.110 4 0.689
TSSK1TSSK1 0.706 0.091 -3 0.812
CDK6CDK6 0.706 0.168 1 0.712
CK1A2CK1A2 0.706 0.064 -3 0.410
TLK1TLK1 0.705 0.067 -2 0.685
CRIKCRIK 0.705 0.375 -3 0.860
MRCKBMRCKB 0.705 0.286 -3 0.840
CK2A2CK2A2 0.704 0.031 1 0.622
YSK4YSK4 0.704 -0.035 1 0.548
PDHK1PDHK1 0.704 -0.238 1 0.624
PLK3PLK3 0.703 -0.039 2 0.726
MEK1MEK1 0.703 -0.038 2 0.797
PERKPERK 0.703 0.054 -2 0.681
ROCK2ROCK2 0.703 0.296 -3 0.841
DMPK1DMPK1 0.703 0.312 -3 0.837
WNK3WNK3 0.703 -0.087 1 0.609
PKCTPKCT 0.703 0.173 2 0.674
BUB1BUB1 0.702 0.217 -5 0.632
GAKGAK 0.702 0.166 1 0.713
PKCIPKCI 0.702 0.160 2 0.702
ULK1ULK1 0.702 -0.144 -3 0.646
PAK4PAK4 0.702 0.142 -2 0.481
MEKK3MEKK3 0.702 0.048 1 0.597
FAM20CFAM20C 0.702 -0.025 2 0.526
MRCKAMRCKA 0.702 0.261 -3 0.838
MST3MST3 0.702 0.101 2 0.811
CHAK1CHAK1 0.702 -0.020 2 0.723
QIKQIK 0.701 0.061 -3 0.787
DCAMKL2DCAMKL2 0.701 0.161 -3 0.823
SMG1SMG1 0.701 -0.034 1 0.635
VRK2VRK2 0.701 -0.037 1 0.729
NEK9NEK9 0.701 -0.121 2 0.763
SNRKSNRK 0.701 0.064 2 0.612
CAMK1ACAMK1A 0.700 0.297 -3 0.828
ERK7ERK7 0.700 0.088 2 0.561
MPSK1MPSK1 0.700 0.130 1 0.703
CK2A1CK2A1 0.700 0.038 1 0.604
PAK5PAK5 0.699 0.129 -2 0.468
BRSK2BRSK2 0.699 0.075 -3 0.807
MARK3MARK3 0.699 0.046 4 0.653
NIM1NIM1 0.698 0.000 3 0.557
MEK5MEK5 0.698 0.011 2 0.764
DNAPKDNAPK 0.697 -0.007 1 0.531
PKN1PKN1 0.696 0.231 -3 0.852
HASPINHASPIN 0.695 0.212 -1 0.710
BCKDKBCKDK 0.695 -0.169 -1 0.575
CK1G1CK1G1 0.694 0.004 -3 0.442
NEK8NEK8 0.694 0.055 2 0.753
CHK1CHK1 0.694 0.055 -3 0.783
TAO3TAO3 0.694 0.028 1 0.587
MEKK2MEKK2 0.693 -0.005 2 0.740
STK33STK33 0.693 0.064 2 0.615
ROCK1ROCK1 0.693 0.287 -3 0.841
HRIHRI 0.693 -0.060 -2 0.663
WNK4WNK4 0.691 0.061 -2 0.594
GCKGCK 0.691 0.088 1 0.576
SSTKSSTK 0.690 0.064 4 0.674
ZAKZAK 0.689 -0.071 1 0.572
PLK2PLK2 0.689 -0.001 -3 0.639
NEK2NEK2 0.689 -0.082 2 0.753
PDK1PDK1 0.689 0.116 1 0.597
NEK5NEK5 0.688 -0.028 1 0.633
MARK1MARK1 0.688 0.020 4 0.658
PHKG2PHKG2 0.688 0.088 -3 0.799
BRAFBRAF 0.687 -0.038 -4 0.734
MARK2MARK2 0.687 -0.010 4 0.618
SLKSLK 0.687 0.055 -2 0.511
IRAK4IRAK4 0.686 0.015 1 0.643
TAK1TAK1 0.686 0.079 1 0.597
LKB1LKB1 0.686 0.049 -3 0.677
HPK1HPK1 0.686 0.085 1 0.558
LRRK2LRRK2 0.685 0.108 2 0.778
YANK3YANK3 0.685 0.048 2 0.424
CK1ACK1A 0.685 0.060 -3 0.325
MEKK1MEKK1 0.685 -0.114 1 0.604
CAMKK1CAMKK1 0.683 -0.066 -2 0.537
EEF2KEEF2K 0.682 -0.007 3 0.660
NEK11NEK11 0.682 -0.039 1 0.573
PKG1PKG1 0.682 0.169 -2 0.389
CAMKK2CAMKK2 0.682 -0.016 -2 0.522
LOKLOK 0.682 0.074 -2 0.527
TNIKTNIK 0.681 0.043 3 0.703
PBKPBK 0.680 0.107 1 0.636
TAO2TAO2 0.680 -0.027 2 0.769
KHS2KHS2 0.680 0.083 1 0.561
TTBK1TTBK1 0.680 -0.073 2 0.604
OSR1OSR1 0.679 0.050 2 0.752
MST2MST2 0.678 -0.071 1 0.575
PLK4PLK4 0.678 -0.110 2 0.575
MEKK6MEKK6 0.675 -0.018 1 0.577
HGKHGK 0.675 -0.028 3 0.692
KHS1KHS1 0.674 0.034 1 0.544
TTKTTK 0.674 0.041 -2 0.681
MAP2K6_TYRMAP2K6_TYR 0.674 0.169 -1 0.689
PDHK4_TYRPDHK4_TYR 0.673 0.152 2 0.811
MST1MST1 0.673 -0.042 1 0.550
PDHK3_TYRPDHK3_TYR 0.672 0.136 4 0.747
BMPR2_TYRBMPR2_TYR 0.672 0.136 -1 0.709
MINKMINK 0.672 -0.048 1 0.551
VRK1VRK1 0.671 -0.049 2 0.743
MAP2K4_TYRMAP2K4_TYR 0.670 0.154 -1 0.677
NEK4NEK4 0.670 -0.074 1 0.573
MAP3K15MAP3K15 0.670 -0.067 1 0.553
CK1G2CK1G2 0.670 0.091 -3 0.363
IRAK1IRAK1 0.668 -0.158 -1 0.617
TESK1_TYRTESK1_TYR 0.668 0.125 3 0.688
ALPHAK3ALPHAK3 0.668 0.036 -1 0.609
PDHK1_TYRPDHK1_TYR 0.667 0.086 -1 0.714
NEK1NEK1 0.667 -0.061 1 0.602
PINK1_TYRPINK1_TYR 0.665 0.094 1 0.673
LIMK2_TYRLIMK2_TYR 0.665 0.163 -3 0.746
PKMYT1_TYRPKMYT1_TYR 0.662 0.045 3 0.650
MYO3BMYO3B 0.662 0.035 2 0.757
BIKEBIKE 0.662 0.036 1 0.646
YSK1YSK1 0.662 -0.043 2 0.744
TXKTXK 0.661 0.066 1 0.665
EPHA6EPHA6 0.661 0.054 -1 0.711
CK1G3CK1G3 0.661 0.040 -3 0.284
MAP2K7_TYRMAP2K7_TYR 0.660 -0.028 2 0.786
MEK2MEK2 0.660 -0.178 2 0.739
EPHB4EPHB4 0.656 -0.002 -1 0.671
FGRFGR 0.656 0.013 1 0.643
RIPK2RIPK2 0.655 -0.170 1 0.515
MYO3AMYO3A 0.654 -0.028 1 0.603
YANK2YANK2 0.654 0.009 2 0.439
LIMK1_TYRLIMK1_TYR 0.653 -0.010 2 0.760
BLKBLK 0.653 0.025 -1 0.700
FLT1FLT1 0.653 0.043 -1 0.689
EPHA4EPHA4 0.652 0.014 2 0.746
FYNFYN 0.652 0.044 -1 0.697
LCKLCK 0.651 0.012 -1 0.704
PTK2PTK2 0.651 0.089 -1 0.679
YES1YES1 0.650 -0.046 -1 0.675
SYKSYK 0.650 0.109 -1 0.667
ITKITK 0.649 -0.019 -1 0.647
RETRET 0.649 -0.057 1 0.600
ABL2ABL2 0.649 0.007 -1 0.625
ASK1ASK1 0.649 -0.104 1 0.547
AAK1AAK1 0.648 0.054 1 0.576
WEE1_TYRWEE1_TYR 0.647 0.045 -1 0.588
METMET 0.647 0.013 3 0.567
MST1RMST1R 0.646 -0.085 3 0.588
TNK2TNK2 0.646 0.013 3 0.517
KDRKDR 0.646 -0.008 3 0.536
NEK3NEK3 0.646 -0.124 1 0.548
TAO1TAO1 0.645 -0.071 1 0.506
DDR1DDR1 0.645 -0.082 4 0.687
SRMSSRMS 0.645 -0.047 1 0.646
ABL1ABL1 0.643 -0.027 -1 0.613
JAK3JAK3 0.642 -0.086 1 0.588
FERFER 0.642 -0.127 1 0.666
EPHB2EPHB2 0.642 -0.057 -1 0.664
HCKHCK 0.642 -0.098 -1 0.685
TYRO3TYRO3 0.641 -0.142 3 0.575
BMXBMX 0.641 -0.038 -1 0.579
STLK3STLK3 0.641 -0.122 1 0.527
KITKIT 0.641 -0.081 3 0.585
CSF1RCSF1R 0.641 -0.121 3 0.573
FGFR2FGFR2 0.641 -0.069 3 0.575
EPHB1EPHB1 0.641 -0.096 1 0.626
EPHB3EPHB3 0.640 -0.074 -1 0.660
INSRRINSRR 0.638 -0.104 3 0.512
EPHA7EPHA7 0.638 -0.049 2 0.735
TECTEC 0.637 -0.073 -1 0.570
EPHA3EPHA3 0.636 -0.060 2 0.707
SRCSRC 0.636 -0.032 -1 0.666
PTK2BPTK2B 0.636 -0.012 -1 0.606
ROS1ROS1 0.635 -0.185 3 0.530
FGFR3FGFR3 0.635 -0.063 3 0.547
FLT3FLT3 0.634 -0.113 3 0.579
EPHA8EPHA8 0.634 -0.035 -1 0.665
ERBB2ERBB2 0.634 -0.079 1 0.559
EPHA5EPHA5 0.634 -0.040 2 0.721
TEKTEK 0.634 -0.099 3 0.512
NEK10_TYRNEK10_TYR 0.633 -0.081 1 0.484
ZAP70ZAP70 0.633 0.083 -1 0.571
FRKFRK 0.633 -0.083 -1 0.696
LYNLYN 0.633 -0.084 3 0.508
TNK1TNK1 0.633 -0.018 3 0.563
TNNI3K_TYRTNNI3K_TYR 0.632 -0.059 1 0.620
TYK2TYK2 0.632 -0.280 1 0.582
JAK2JAK2 0.632 -0.226 1 0.576
MERTKMERTK 0.631 -0.110 3 0.556
DDR2DDR2 0.631 -0.014 3 0.495
MATKMATK 0.630 -0.057 -1 0.565
PDGFRBPDGFRB 0.630 -0.166 3 0.575
FLT4FLT4 0.630 -0.103 3 0.542
PTK6PTK6 0.629 -0.140 -1 0.572
BTKBTK 0.629 -0.175 -1 0.603
EPHA1EPHA1 0.628 -0.102 3 0.540
ERBB4ERBB4 0.626 -0.014 1 0.524
FGFR1FGFR1 0.626 -0.160 3 0.519
AXLAXL 0.626 -0.147 3 0.545
EPHA2EPHA2 0.625 -0.041 -1 0.638
EGFREGFR 0.625 -0.070 1 0.487
FGFR4FGFR4 0.622 -0.076 -1 0.607
LTKLTK 0.622 -0.152 3 0.502
PDGFRAPDGFRA 0.621 -0.211 3 0.576
CSKCSK 0.621 -0.115 2 0.734
ALKALK 0.621 -0.175 3 0.468
NTRK1NTRK1 0.619 -0.210 -1 0.619
JAK1JAK1 0.619 -0.184 1 0.518
NTRK3NTRK3 0.617 -0.151 -1 0.582
NTRK2NTRK2 0.615 -0.234 3 0.536
INSRINSR 0.613 -0.208 3 0.495
IGF1RIGF1R 0.608 -0.149 3 0.452
MUSKMUSK 0.606 -0.145 1 0.476
FESFES 0.592 -0.171 -1 0.549