Motif 323 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NEQ0 | RBMY1E | S475 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member E | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| O14646 | CHD1 | S1100 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O60307 | MAST3 | S157 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O60759 | CYTIP | S314 | ochoa | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. |
| O75122 | CLASP2 | S463 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75494 | SRSF10 | S133 | ochoa|psp | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}. |
| O75494 | SRSF10 | S143 | ochoa | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}. |
| O75494 | SRSF10 | S160 | ochoa | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}. |
| O94913 | PCF11 | S494 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94913 | PCF11 | S511 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95218 | ZRANB2 | S279 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| P0C7P1 | RBMY1D | S475 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member D | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| P0DJD3 | RBMY1A1 | S475 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}. |
| P0DJD4 | RBMY1C | S475 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member C | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
| P10070 | GLI2 | S236 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P18583 | SON | S1952 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18583 | SON | S2013 | ochoa|psp | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18583 | SON | S2031 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18615 | NELFE | S251 | ochoa|psp | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P23588 | EIF4B | S311 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P49450 | CENPA | T21 | ochoa|psp | Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) | Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}. |
| P49450 | CENPA | T23 | ochoa|psp | Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) | Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}. |
| P49760 | CLK2 | S50 | ochoa | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
| P53671 | LIMK2 | S293 | ochoa|psp | LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:8537403}. |
| P62995 | TRA2B | S99 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| Q02241 | KIF23 | S686 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q03164 | KMT2A | S2201 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07157 | TJP1 | S315 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08170 | SRSF4 | S422 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q12872 | SFSWAP | S872 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q13523 | PRP4K | S387 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13595 | TRA2A | S100 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Q14004 | CDK13 | S385 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14004 | CDK13 | S441 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q5BKX8 | CAVIN4 | S260 | ochoa | Caveolae-associated protein 4 (Muscle-related coiled-coil protein) (Muscle-restricted coiled-coil protein) | Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). {ECO:0000250|UniProtKB:A2AMM0, ECO:0000269|PubMed:18332105}. |
| Q5T200 | ZC3H13 | S642 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T200 | ZC3H13 | S1366 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5VTL8 | PRPF38B | S290 | ochoa | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | May be required for pre-mRNA splicing. {ECO:0000305}. |
| Q5VV67 | PPRC1 | S1413 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q6UN15 | FIP1L1 | S492 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6UN15 | FIP1L1 | T494 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6UN15 | FIP1L1 | S496 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6Y7W6 | GIGYF2 | S277 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q6ZVL6 | KIAA1549L | S1481 | ochoa | UPF0606 protein KIAA1549L | None |
| Q7L4I2 | RSRC2 | S218 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7L4I2 | RSRC2 | S222 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7Z6E9 | RBBP6 | S698 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6E9 | RBBP6 | S772 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86SU0 | ILDR1 | S469 | ochoa | Immunoglobulin-like domain-containing receptor 1 (Angulin-2) | Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:Q8CBR1, ECO:0000269|PubMed:23239027}.; FUNCTION: (Microbial infection) Promotes influenza virus infection by inhibiting viral nucleoprotein NP binding to PLSCR1 and thereby PLSCR1-mediated antiviral activity. {ECO:0000269|PubMed:35595813}. |
| Q86UR5 | RIMS1 | S999 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86VM9 | ZC3H18 | S605 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86VM9 | ZC3H18 | S609 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8IWX8 | CHERP | T819 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IXT5 | RBM12B | S280 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8IYB3 | SRRM1 | S211 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N2M8 | CLASRP | S285 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N5Y2 | MSL3 | S367 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
| Q8N8E3 | CEP112 | S173 | ochoa | Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) | None |
| Q8NB49 | ATP11C | S1112 | ochoa | Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24904167, PubMed:25315773, PubMed:26567335, PubMed:32493773). Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:26944472). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). {ECO:0000250|UniProtKB:Q9QZW0, ECO:0000269|PubMed:24904167, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:26944472, ECO:0000269|PubMed:32493773}. |
| Q8NDB6 | FAM156A | S114 | ochoa | Protein FAM156A/FAM156B (Transmembrane protein 29/29B) | None |
| Q8NDT2 | RBM15B | S556 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
| Q8TC71 | SPATA18 | S509 | ochoa | Mitochondria-eating protein (Spermatogenesis-associated protein 18) | Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage (PubMed:21264221, PubMed:21264228, PubMed:22292033, PubMed:22532927). Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen (PubMed:21264221, PubMed:21264228, PubMed:22292033, PubMed:22532927). Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (PubMed:21264228). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (PubMed:22292033). Binds cardiolipin (PubMed:38322995). May form molecular condensates (non-membrane-bounded organelles) within mitochondria that compartmentalize and promote cardiolipin metabolism (PubMed:38322995). {ECO:0000269|PubMed:21264221, ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033, ECO:0000269|PubMed:38322995}. |
| Q96GE4 | CEP95 | S453 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96QZ7 | MAGI1 | S1412 | ochoa | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3) | Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6RHR9}. |
| Q96T37 | RBM15 | S670 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99590 | SCAF11 | S882 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S902 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S953 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S963 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BRD0 | BUD13 | S391 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BSF8 | BTBD10 | T79 | ochoa | BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) | Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. {ECO:0000250|UniProtKB:Q80X66}. |
| Q9BXP5 | SRRT | S67 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BZE4 | GTPBP4 | S562 | ochoa | GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1) | Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539). {ECO:0000269|PubMed:20308539, ECO:0000269|PubMed:32669547}. |
| Q9C0B0 | UNK | S85 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9H2D6 | TRIOBP | S638 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S662 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S710 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S758 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S805 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H6R7 | WDCP | S690 | ochoa | WD repeat and coiled-coil-containing protein | None |
| Q9H7N4 | SCAF1 | S614 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HC52 | CBX8 | S191 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
| Q9HCD5 | NCOA5 | S116 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCG8 | CWC22 | S866 | ochoa | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q9NRR4 | DROSHA | S302 | psp | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q9NXX6 | NSMCE4A | S32 | ochoa | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}. |
| Q9NYV4 | CDK12 | S385 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZJ0 | DTL | S490 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9P1Y6 | PHRF1 | S1095 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P1Y6 | PHRF1 | S1128 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P1Y6 | PHRF1 | S1165 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P246 | STIM2 | S523 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9UBN1 | CACNG4 | S255 | ochoa | Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage-gated calcium channel gamma-4 subunit) (Transmembrane AMPAR regulatory protein gamma-4) (TARP gamma-4) | Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611). {ECO:0000269|PubMed:21127204, ECO:0000269|PubMed:21172611}. |
| Q9UBN1 | CACNG4 | S259 | ochoa | Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage-gated calcium channel gamma-4 subunit) (Transmembrane AMPAR regulatory protein gamma-4) (TARP gamma-4) | Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611). {ECO:0000269|PubMed:21127204, ECO:0000269|PubMed:21172611}. |
| Q9UDY2 | TJP2 | S296 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UKJ3 | GPATCH8 | S1035 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKV3 | ACIN1 | S657 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UPN3 | MACF1 | S35 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPQ0 | LIMCH1 | S192 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ26 | RIMS2 | S1072 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9UQ26 | RIMS2 | S1148 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9UQ35 | SRRM2 | S486 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S510 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1694 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1732 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | Y1820 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T1856 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T1880 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T1927 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T1974 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T1986 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T2022 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T2034 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2046 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T2104 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2706 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2H9 | MAST1 | S163 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2L6 | FRMD4B | S778 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y383 | LUC7L2 | S370 | ochoa | Putative RNA-binding protein Luc7-like 2 | May bind to RNA via its Arg/Ser-rich domain. |
| Q9Y5B9 | SUPT16H | S1017 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| Q9Y6R9 | CCDC61 | S336 | ochoa | Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}. |
| Q14152 | EIF3A | S1308 | Sugiyama | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P84103 | SRSF3 | S95 | Sugiyama | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32440474}. |
| Q86VM9 | ZC3H18 | S607 | Sugiyama | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.616578e-09 | 8.791 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.439159e-09 | 8.464 |
| R-HSA-72172 | mRNA Splicing | 5.985545e-09 | 8.223 |
| R-HSA-72187 | mRNA 3'-end processing | 2.558669e-05 | 4.592 |
| R-HSA-8953854 | Metabolism of RNA | 2.324314e-05 | 4.634 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.945339e-05 | 4.306 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 9.813861e-04 | 3.008 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.502501e-03 | 2.823 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.522199e-03 | 2.818 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.367116e-03 | 2.864 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.771633e-03 | 2.752 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.835117e-03 | 2.736 |
| R-HSA-75153 | Apoptotic execution phase | 3.676699e-03 | 2.435 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 6.447951e-03 | 2.191 |
| R-HSA-2028269 | Signaling by Hippo | 7.050870e-03 | 2.152 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.112838e-02 | 1.954 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 1.524145e-02 | 1.817 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 1.524145e-02 | 1.817 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.612050e-02 | 1.793 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.612050e-02 | 1.793 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.650824e-02 | 1.782 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.650824e-02 | 1.782 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.273438e-02 | 1.895 |
| R-HSA-9930044 | Nuclear RNA decay | 2.082918e-02 | 1.681 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 2.786441e-02 | 1.555 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.938800e-02 | 1.532 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.938800e-02 | 1.532 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.825261e-02 | 1.549 |
| R-HSA-167169 | HIV Transcription Elongation | 2.938800e-02 | 1.532 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.539627e-02 | 1.595 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.041824e-02 | 1.517 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.161233e-02 | 1.500 |
| R-HSA-191650 | Regulation of gap junction activity | 3.334444e-02 | 1.477 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 3.334444e-02 | 1.477 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 3.879392e-02 | 1.411 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.570332e-02 | 1.340 |
| R-HSA-72649 | Translation initiation complex formation | 4.845199e-02 | 1.315 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.125945e-02 | 1.290 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 4.421301e-02 | 1.354 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.707020e-02 | 1.327 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.152975e-02 | 1.382 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.123965e-02 | 1.290 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.125945e-02 | 1.290 |
| R-HSA-74160 | Gene expression (Transcription) | 5.296362e-02 | 1.276 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.412407e-02 | 1.267 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.630268e-02 | 1.249 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 7.609877e-02 | 1.119 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 8.130980e-02 | 1.090 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.891171e-02 | 1.103 |
| R-HSA-167172 | Transcription of the HIV genome | 6.924930e-02 | 1.160 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 8.130980e-02 | 1.090 |
| R-HSA-5682910 | LGI-ADAM interactions | 7.609877e-02 | 1.119 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.924930e-02 | 1.160 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 8.649176e-02 | 1.063 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.269200e-01 | 0.896 |
| R-HSA-429947 | Deadenylation of mRNA | 1.560751e-01 | 0.807 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.421934e-01 | 0.616 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.655778e-01 | 0.781 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.119711e-01 | 0.951 |
| R-HSA-5576893 | Phase 2 - plateau phase | 1.119711e-01 | 0.951 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.219649e-01 | 0.914 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 1.749747e-01 | 0.757 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.675508e-01 | 0.776 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.675508e-01 | 0.776 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.464653e-01 | 0.834 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 1.749747e-01 | 0.757 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 1.367474e-01 | 0.864 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 1.560751e-01 | 0.807 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.560751e-01 | 0.807 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 1.749747e-01 | 0.757 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.291979e-01 | 0.640 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.478236e-01 | 0.830 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.478236e-01 | 0.830 |
| R-HSA-68877 | Mitotic Prometaphase | 1.189288e-01 | 0.925 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.305269e-01 | 0.884 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.288683e-01 | 0.640 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.378858e-01 | 0.624 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.184980e-01 | 0.661 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 1.655778e-01 | 0.781 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.888741e-01 | 0.724 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.456917e-02 | 1.073 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.115270e-01 | 0.675 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.842669e-01 | 0.735 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.980115e-01 | 0.703 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.011475e-01 | 0.995 |
| R-HSA-9659379 | Sensory processing of sound | 8.726565e-02 | 1.059 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.318474e-01 | 0.880 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.378858e-01 | 0.624 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.464653e-01 | 0.834 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 1.608398e-01 | 0.794 |
| R-HSA-68886 | M Phase | 1.942013e-01 | 0.712 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.980115e-01 | 0.703 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.335540e-01 | 0.632 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.416199e-01 | 0.849 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.608398e-01 | 0.794 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.082077e-01 | 0.682 |
| R-HSA-68882 | Mitotic Anaphase | 1.495464e-01 | 0.825 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.508742e-01 | 0.821 |
| R-HSA-165159 | MTOR signalling | 2.464769e-01 | 0.608 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.159819e-01 | 0.666 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.411287e-01 | 0.850 |
| R-HSA-8939211 | ESR-mediated signaling | 1.781889e-01 | 0.749 |
| R-HSA-109581 | Apoptosis | 8.245422e-02 | 1.084 |
| R-HSA-5357801 | Programmed Cell Death | 1.352051e-01 | 0.869 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.549722e-01 | 0.594 |
| R-HSA-774815 | Nucleosome assembly | 2.591843e-01 | 0.586 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.591843e-01 | 0.586 |
| R-HSA-162587 | HIV Life Cycle | 2.601487e-01 | 0.585 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.633728e-01 | 0.579 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.757983e-01 | 0.559 |
| R-HSA-73893 | DNA Damage Bypass | 2.757983e-01 | 0.559 |
| R-HSA-9864848 | Complex IV assembly | 2.839666e-01 | 0.547 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.157384e-01 | 0.501 |
| R-HSA-983189 | Kinesins | 3.196105e-01 | 0.495 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.196105e-01 | 0.495 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.272899e-01 | 0.485 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.310973e-01 | 0.480 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.310973e-01 | 0.480 |
| R-HSA-373755 | Semaphorin interactions | 3.310973e-01 | 0.480 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.348835e-01 | 0.475 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.423923e-01 | 0.465 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.423923e-01 | 0.465 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.498173e-01 | 0.456 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.576221e-01 | 0.447 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.607996e-01 | 0.443 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.680190e-01 | 0.434 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.682433e-01 | 0.434 |
| R-HSA-380287 | Centrosome maturation | 3.751577e-01 | 0.426 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.960989e-01 | 0.402 |
| R-HSA-212436 | Generic Transcription Pathway | 3.971115e-01 | 0.401 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.029238e-01 | 0.395 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.063076e-01 | 0.391 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.063076e-01 | 0.391 |
| R-HSA-162906 | HIV Infection | 4.077815e-01 | 0.390 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.163457e-01 | 0.381 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.215017e-01 | 0.375 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.229442e-01 | 0.374 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.247477e-01 | 0.372 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.294690e-01 | 0.367 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.294690e-01 | 0.367 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.391196e-01 | 0.357 |
| R-HSA-4839726 | Chromatin organization | 4.503520e-01 | 0.346 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.517364e-01 | 0.345 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.548465e-01 | 0.342 |
| R-HSA-3214847 | HATs acetylate histones | 4.640724e-01 | 0.333 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.731439e-01 | 0.325 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.908337e-01 | 0.309 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.908337e-01 | 0.309 |
| R-HSA-211000 | Gene Silencing by RNA | 4.908337e-01 | 0.309 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.108852e-01 | 0.292 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.162726e-01 | 0.287 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.244696e-01 | 0.280 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.298578e-01 | 0.276 |
| R-HSA-73886 | Chromosome Maintenance | 5.351857e-01 | 0.271 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.404538e-01 | 0.267 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.404538e-01 | 0.267 |
| R-HSA-5576891 | Cardiac conduction | 5.659214e-01 | 0.247 |
| R-HSA-9909396 | Circadian clock | 5.683901e-01 | 0.245 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.683901e-01 | 0.245 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.750621e-01 | 0.240 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.798646e-01 | 0.237 |
| R-HSA-6807070 | PTEN Regulation | 5.876459e-01 | 0.231 |
| R-HSA-1640170 | Cell Cycle | 5.944736e-01 | 0.226 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.236445e-01 | 0.205 |
| R-HSA-422475 | Axon guidance | 6.242710e-01 | 0.205 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.363271e-01 | 0.196 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.623740e-01 | 0.179 |
| R-HSA-9675108 | Nervous system development | 6.668941e-01 | 0.176 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.681177e-01 | 0.175 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.690107e-01 | 0.175 |
| R-HSA-162582 | Signal Transduction | 6.701842e-01 | 0.174 |
| R-HSA-611105 | Respiratory electron transport | 6.737648e-01 | 0.171 |
| R-HSA-2559583 | Cellular Senescence | 6.774766e-01 | 0.169 |
| R-HSA-69275 | G2/M Transition | 6.883632e-01 | 0.162 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.919107e-01 | 0.160 |
| R-HSA-983712 | Ion channel transport | 6.936695e-01 | 0.159 |
| R-HSA-5617833 | Cilium Assembly | 6.954183e-01 | 0.158 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.123723e-01 | 0.147 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.123723e-01 | 0.147 |
| R-HSA-72766 | Translation | 7.257769e-01 | 0.139 |
| R-HSA-397014 | Muscle contraction | 7.330239e-01 | 0.135 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.330239e-01 | 0.135 |
| R-HSA-8951664 | Neddylation | 7.464551e-01 | 0.127 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.564376e-01 | 0.121 |
| R-HSA-112316 | Neuronal System | 7.673377e-01 | 0.115 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.926258e-01 | 0.101 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.064565e-01 | 0.093 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.101431e-01 | 0.091 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.343278e-01 | 0.079 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.590396e-01 | 0.066 |
| R-HSA-1280218 | Adaptive Immune System | 8.604339e-01 | 0.065 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.729621e-01 | 0.059 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.736943e-01 | 0.059 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.787047e-01 | 0.056 |
| R-HSA-73894 | DNA Repair | 8.861837e-01 | 0.052 |
| R-HSA-199991 | Membrane Trafficking | 8.959733e-01 | 0.048 |
| R-HSA-6798695 | Neutrophil degranulation | 9.355676e-01 | 0.029 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.515937e-01 | 0.022 |
| R-HSA-9824446 | Viral Infection Pathways | 9.616499e-01 | 0.017 |
| R-HSA-9679506 | SARS-CoV Infections | 9.636546e-01 | 0.016 |
| R-HSA-1266738 | Developmental Biology | 9.727863e-01 | 0.012 |
| R-HSA-2262752 | Cellular responses to stress | 9.831744e-01 | 0.007 |
| R-HSA-597592 | Post-translational protein modification | 9.885423e-01 | 0.005 |
| R-HSA-109582 | Hemostasis | 9.905977e-01 | 0.004 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.913279e-01 | 0.004 |
| R-HSA-9709957 | Sensory Perception | 9.946866e-01 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 9.959750e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.971093e-01 | 0.001 |
| R-HSA-5663205 | Infectious disease | 9.974795e-01 | 0.001 |
| R-HSA-168249 | Innate Immune System | 9.996536e-01 | 0.000 |
| R-HSA-168256 | Immune System | 9.998073e-01 | 0.000 |
| R-HSA-1643685 | Disease | 9.998600e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.806 | 0.604 | 1 | 0.901 |
SRPK1 |
0.797 | 0.501 | -3 | 0.899 |
HIPK1 |
0.795 | 0.599 | 1 | 0.862 |
CLK2 |
0.794 | 0.505 | -3 | 0.893 |
SRPK2 |
0.791 | 0.475 | -3 | 0.877 |
SRPK3 |
0.791 | 0.486 | -3 | 0.870 |
KIS |
0.790 | 0.572 | 1 | 0.886 |
DYRK2 |
0.790 | 0.565 | 1 | 0.866 |
CLK3 |
0.789 | 0.490 | 1 | 0.705 |
CDK10 |
0.787 | 0.579 | 1 | 0.895 |
DYRK1B |
0.787 | 0.565 | 1 | 0.884 |
DYRK4 |
0.786 | 0.554 | 1 | 0.908 |
DYRK3 |
0.782 | 0.513 | 1 | 0.837 |
CLK4 |
0.781 | 0.444 | -3 | 0.891 |
HIPK3 |
0.781 | 0.563 | 1 | 0.854 |
CLK1 |
0.781 | 0.466 | -3 | 0.881 |
DYRK1A |
0.779 | 0.530 | 1 | 0.867 |
HIPK4 |
0.776 | 0.444 | 1 | 0.748 |
CDK12 |
0.773 | 0.525 | 1 | 0.915 |
CDK7 |
0.770 | 0.484 | 1 | 0.897 |
CDK1 |
0.770 | 0.500 | 1 | 0.899 |
JNK2 |
0.769 | 0.511 | 1 | 0.916 |
CDK13 |
0.769 | 0.508 | 1 | 0.908 |
P38G |
0.769 | 0.511 | 1 | 0.906 |
MAK |
0.769 | 0.449 | -2 | 0.441 |
CDK19 |
0.768 | 0.468 | 1 | 0.895 |
CDK18 |
0.768 | 0.491 | 1 | 0.895 |
CDK14 |
0.767 | 0.523 | 1 | 0.890 |
JNK3 |
0.766 | 0.509 | 1 | 0.910 |
NLK |
0.766 | 0.526 | 1 | 0.775 |
ERK1 |
0.766 | 0.488 | 1 | 0.891 |
CDK17 |
0.765 | 0.500 | 1 | 0.898 |
CDK8 |
0.765 | 0.463 | 1 | 0.889 |
CDK9 |
0.764 | 0.496 | 1 | 0.906 |
CDK4 |
0.762 | 0.533 | 1 | 0.910 |
CDKL1 |
0.761 | 0.350 | -3 | 0.888 |
ICK |
0.761 | 0.392 | -3 | 0.884 |
CDKL5 |
0.760 | 0.311 | -3 | 0.898 |
MOK |
0.760 | 0.462 | 1 | 0.764 |
P38B |
0.759 | 0.467 | 1 | 0.876 |
ERK2 |
0.759 | 0.494 | 1 | 0.892 |
RSK2 |
0.758 | 0.266 | -3 | 0.904 |
CDK5 |
0.757 | 0.473 | 1 | 0.874 |
P38D |
0.757 | 0.479 | 1 | 0.893 |
CDK3 |
0.756 | 0.422 | 1 | 0.896 |
P38A |
0.756 | 0.456 | 1 | 0.859 |
CDK16 |
0.755 | 0.472 | 1 | 0.894 |
CDK6 |
0.755 | 0.504 | 1 | 0.895 |
PRKX |
0.751 | 0.227 | -3 | 0.868 |
PIM3 |
0.751 | 0.228 | -3 | 0.878 |
NDR2 |
0.751 | 0.188 | -3 | 0.853 |
RSK4 |
0.751 | 0.276 | -3 | 0.899 |
PIM1 |
0.751 | 0.271 | -3 | 0.888 |
RSK3 |
0.751 | 0.251 | -3 | 0.894 |
P90RSK |
0.750 | 0.260 | -3 | 0.904 |
AKT2 |
0.749 | 0.271 | -3 | 0.884 |
PIM2 |
0.749 | 0.309 | -3 | 0.890 |
PKACB |
0.749 | 0.193 | -2 | 0.420 |
NDR1 |
0.749 | 0.197 | -3 | 0.862 |
JNK1 |
0.748 | 0.455 | 1 | 0.908 |
AURC |
0.747 | 0.123 | -2 | 0.420 |
P70S6KB |
0.747 | 0.251 | -3 | 0.879 |
PKACG |
0.747 | 0.172 | -2 | 0.459 |
MTOR |
0.746 | 0.184 | 1 | 0.637 |
ERK5 |
0.744 | 0.237 | 1 | 0.655 |
COT |
0.744 | 0.079 | 2 | 0.848 |
PRP4 |
0.743 | 0.326 | -3 | 0.672 |
NUAK2 |
0.742 | 0.213 | -3 | 0.876 |
LATS2 |
0.741 | 0.130 | -5 | 0.756 |
MOS |
0.740 | 0.152 | 1 | 0.511 |
AKT1 |
0.739 | 0.235 | -3 | 0.884 |
SGK1 |
0.739 | 0.285 | -3 | 0.861 |
CAMK1B |
0.739 | 0.180 | -3 | 0.855 |
GRK1 |
0.739 | 0.185 | -2 | 0.651 |
SGK3 |
0.739 | 0.217 | -3 | 0.880 |
MSK2 |
0.738 | 0.195 | -3 | 0.882 |
PRKD2 |
0.738 | 0.189 | -3 | 0.882 |
PKACA |
0.738 | 0.180 | -2 | 0.388 |
MSK1 |
0.738 | 0.189 | -3 | 0.880 |
PKN3 |
0.737 | 0.150 | -3 | 0.862 |
AURB |
0.737 | 0.099 | -2 | 0.413 |
CAMLCK |
0.737 | 0.154 | -2 | 0.510 |
PKG2 |
0.737 | 0.134 | -2 | 0.411 |
PKN2 |
0.737 | 0.163 | -3 | 0.835 |
MST4 |
0.736 | 0.104 | 2 | 0.839 |
AKT3 |
0.735 | 0.250 | -3 | 0.868 |
SKMLCK |
0.735 | 0.102 | -2 | 0.543 |
LATS1 |
0.735 | 0.150 | -3 | 0.846 |
CDC7 |
0.734 | 0.012 | 1 | 0.463 |
DAPK2 |
0.734 | 0.159 | -3 | 0.846 |
NIK |
0.733 | 0.156 | -3 | 0.808 |
P70S6K |
0.733 | 0.267 | -3 | 0.868 |
PKCD |
0.733 | 0.118 | 2 | 0.754 |
WNK1 |
0.732 | 0.087 | -2 | 0.512 |
MYLK4 |
0.732 | 0.157 | -2 | 0.493 |
IKKB |
0.732 | -0.002 | -2 | 0.434 |
GRK7 |
0.732 | 0.151 | 1 | 0.469 |
RAF1 |
0.732 | -0.002 | 1 | 0.477 |
MAPKAPK3 |
0.732 | 0.146 | -3 | 0.864 |
PAK1 |
0.732 | 0.099 | -2 | 0.483 |
TGFBR2 |
0.731 | 0.022 | -2 | 0.529 |
PRKD3 |
0.731 | 0.193 | -3 | 0.874 |
MAPKAPK2 |
0.731 | 0.171 | -3 | 0.871 |
CDK2 |
0.730 | 0.327 | 1 | 0.840 |
AMPKA1 |
0.730 | 0.113 | -3 | 0.854 |
AURA |
0.730 | 0.073 | -2 | 0.419 |
PRPK |
0.729 | -0.032 | -1 | 0.722 |
AMPKA2 |
0.729 | 0.137 | -3 | 0.865 |
ATR |
0.728 | 0.004 | 1 | 0.477 |
PAK3 |
0.728 | 0.077 | -2 | 0.467 |
PKCG |
0.728 | 0.126 | 2 | 0.690 |
PRKD1 |
0.726 | 0.099 | -3 | 0.861 |
PAK2 |
0.726 | 0.085 | -2 | 0.471 |
MNK1 |
0.726 | 0.101 | -2 | 0.465 |
PASK |
0.726 | 0.210 | -3 | 0.860 |
TBK1 |
0.726 | -0.091 | 1 | 0.438 |
BMPR2 |
0.725 | -0.068 | -2 | 0.527 |
CRIK |
0.725 | 0.302 | -3 | 0.894 |
CAMK2A |
0.725 | 0.125 | 2 | 0.798 |
DCAMKL1 |
0.724 | 0.164 | -3 | 0.867 |
PHKG1 |
0.724 | 0.115 | -3 | 0.850 |
BMPR1B |
0.724 | 0.057 | 1 | 0.424 |
GRK5 |
0.724 | -0.001 | -3 | 0.693 |
PDHK4 |
0.724 | -0.133 | 1 | 0.543 |
CAMK1G |
0.724 | 0.187 | -3 | 0.867 |
CHAK2 |
0.724 | 0.015 | -1 | 0.746 |
PKCB |
0.724 | 0.111 | 2 | 0.688 |
CAMK4 |
0.723 | 0.080 | -3 | 0.838 |
PKCA |
0.723 | 0.106 | 2 | 0.686 |
MRCKB |
0.723 | 0.210 | -3 | 0.869 |
IKKE |
0.722 | -0.098 | 1 | 0.432 |
CAMK2G |
0.722 | -0.024 | 2 | 0.809 |
RIPK3 |
0.722 | -0.011 | 3 | 0.616 |
GCN2 |
0.722 | -0.064 | 2 | 0.768 |
PKCE |
0.722 | 0.177 | 2 | 0.673 |
MELK |
0.722 | 0.110 | -3 | 0.859 |
PKCH |
0.721 | 0.115 | 2 | 0.667 |
RIPK1 |
0.721 | 0.032 | 1 | 0.475 |
ERK7 |
0.721 | 0.172 | 2 | 0.528 |
MLK1 |
0.720 | -0.018 | 2 | 0.765 |
HUNK |
0.720 | 0.002 | 2 | 0.769 |
DLK |
0.720 | 0.003 | 1 | 0.496 |
MAPKAPK5 |
0.720 | 0.148 | -3 | 0.848 |
IRE1 |
0.720 | 0.058 | 1 | 0.446 |
CAMK2D |
0.720 | 0.029 | -3 | 0.834 |
ROCK2 |
0.720 | 0.206 | -3 | 0.874 |
GSK3A |
0.719 | 0.187 | 4 | 0.547 |
PAK6 |
0.719 | 0.049 | -2 | 0.401 |
CK1D |
0.719 | 0.151 | -3 | 0.380 |
DAPK3 |
0.719 | 0.180 | -3 | 0.877 |
MPSK1 |
0.719 | 0.128 | 1 | 0.477 |
DAPK1 |
0.719 | 0.185 | -3 | 0.881 |
SMMLCK |
0.718 | 0.160 | -3 | 0.865 |
ALK4 |
0.718 | -0.003 | -2 | 0.541 |
MRCKA |
0.718 | 0.190 | -3 | 0.867 |
WNK3 |
0.718 | -0.039 | 1 | 0.474 |
DSTYK |
0.718 | -0.063 | 2 | 0.849 |
PKCZ |
0.718 | 0.070 | 2 | 0.736 |
TTBK2 |
0.717 | 0.027 | 2 | 0.665 |
CAMK2B |
0.717 | 0.069 | 2 | 0.792 |
DMPK1 |
0.717 | 0.228 | -3 | 0.873 |
NUAK1 |
0.717 | 0.108 | -3 | 0.868 |
GRK4 |
0.717 | 0.034 | -2 | 0.614 |
BRSK1 |
0.717 | 0.112 | -3 | 0.866 |
CHK2 |
0.716 | 0.229 | -3 | 0.855 |
PAK5 |
0.716 | 0.070 | -2 | 0.384 |
SIK |
0.716 | 0.119 | -3 | 0.849 |
MARK4 |
0.716 | -0.014 | 4 | 0.768 |
GRK2 |
0.716 | 0.044 | -2 | 0.530 |
QSK |
0.716 | 0.075 | 4 | 0.742 |
CK1E |
0.716 | 0.120 | -3 | 0.428 |
PKCT |
0.716 | 0.117 | 2 | 0.682 |
PKR |
0.716 | 0.051 | 1 | 0.472 |
MLK3 |
0.715 | 0.001 | 2 | 0.697 |
SBK |
0.715 | 0.271 | -3 | 0.838 |
QIK |
0.714 | 0.043 | -3 | 0.823 |
CAMK1D |
0.714 | 0.178 | -3 | 0.866 |
MNK2 |
0.714 | 0.029 | -2 | 0.450 |
MST3 |
0.714 | 0.102 | 2 | 0.799 |
TSSK1 |
0.714 | 0.034 | -3 | 0.859 |
PDHK1 |
0.714 | -0.188 | 1 | 0.511 |
MASTL |
0.714 | -0.094 | -2 | 0.474 |
NIM1 |
0.714 | 0.014 | 3 | 0.680 |
ROCK1 |
0.713 | 0.207 | -3 | 0.866 |
ANKRD3 |
0.713 | -0.049 | 1 | 0.487 |
PKCI |
0.713 | 0.116 | 2 | 0.704 |
GRK6 |
0.713 | -0.027 | 1 | 0.468 |
IKKA |
0.713 | -0.060 | -2 | 0.432 |
HASPIN |
0.712 | 0.175 | -1 | 0.752 |
TAO3 |
0.712 | 0.089 | 1 | 0.496 |
NEK6 |
0.712 | -0.094 | -2 | 0.496 |
PAK4 |
0.711 | 0.064 | -2 | 0.396 |
PKN1 |
0.711 | 0.167 | -3 | 0.872 |
VRK2 |
0.711 | 0.033 | 1 | 0.561 |
TGFBR1 |
0.711 | -0.027 | -2 | 0.537 |
NEK7 |
0.711 | -0.127 | -3 | 0.671 |
DCAMKL2 |
0.711 | 0.102 | -3 | 0.863 |
ALK2 |
0.711 | 0.000 | -2 | 0.555 |
IRE2 |
0.710 | 0.031 | 2 | 0.709 |
ULK2 |
0.710 | -0.176 | 2 | 0.748 |
CK1A2 |
0.709 | 0.104 | -3 | 0.392 |
WNK4 |
0.709 | 0.039 | -2 | 0.488 |
YSK4 |
0.709 | -0.081 | 1 | 0.459 |
GRK3 |
0.709 | 0.056 | -2 | 0.546 |
BRSK2 |
0.709 | 0.044 | -3 | 0.844 |
DRAK1 |
0.708 | -0.001 | 1 | 0.447 |
MEKK3 |
0.708 | 0.051 | 1 | 0.478 |
ACVR2B |
0.708 | -0.040 | -2 | 0.519 |
PKG1 |
0.708 | 0.120 | -2 | 0.352 |
BCKDK |
0.707 | -0.118 | -1 | 0.651 |
PHKG2 |
0.707 | 0.096 | -3 | 0.839 |
ATM |
0.707 | -0.036 | 1 | 0.421 |
PINK1 |
0.707 | 0.079 | 1 | 0.613 |
MLK2 |
0.707 | -0.122 | 2 | 0.778 |
MEK5 |
0.706 | 0.019 | 2 | 0.783 |
PLK1 |
0.706 | -0.096 | -2 | 0.469 |
MEK1 |
0.706 | -0.078 | 2 | 0.805 |
DNAPK |
0.706 | -0.034 | 1 | 0.432 |
ACVR2A |
0.706 | -0.050 | -2 | 0.505 |
NEK9 |
0.705 | -0.158 | 2 | 0.794 |
CHAK1 |
0.705 | -0.022 | 2 | 0.727 |
TSSK2 |
0.705 | -0.044 | -5 | 0.655 |
MLK4 |
0.705 | -0.028 | 2 | 0.681 |
PDK1 |
0.704 | 0.090 | 1 | 0.508 |
SNRK |
0.704 | 0.014 | 2 | 0.643 |
HPK1 |
0.704 | 0.108 | 1 | 0.469 |
BMPR1A |
0.704 | -0.001 | 1 | 0.407 |
PERK |
0.703 | -0.040 | -2 | 0.528 |
GSK3B |
0.703 | 0.087 | 4 | 0.542 |
KHS2 |
0.703 | 0.142 | 1 | 0.468 |
TAO2 |
0.703 | 0.066 | 2 | 0.810 |
GCK |
0.703 | 0.086 | 1 | 0.471 |
MARK3 |
0.703 | 0.017 | 4 | 0.703 |
CAMK1A |
0.702 | 0.174 | -3 | 0.848 |
GAK |
0.701 | 0.089 | 1 | 0.481 |
SMG1 |
0.701 | -0.068 | 1 | 0.442 |
ULK1 |
0.701 | -0.165 | -3 | 0.635 |
BUB1 |
0.701 | 0.076 | -5 | 0.653 |
SLK |
0.700 | 0.029 | -2 | 0.412 |
CK1G1 |
0.700 | 0.059 | -3 | 0.412 |
LOK |
0.700 | 0.043 | -2 | 0.419 |
ZAK |
0.699 | -0.056 | 1 | 0.477 |
TLK2 |
0.699 | -0.105 | 1 | 0.430 |
CHK1 |
0.699 | -0.025 | -3 | 0.823 |
MEKK2 |
0.698 | -0.025 | 2 | 0.758 |
MEKK1 |
0.698 | -0.079 | 1 | 0.473 |
NEK2 |
0.698 | -0.113 | 2 | 0.769 |
HRI |
0.698 | -0.086 | -2 | 0.507 |
TLK1 |
0.698 | -0.036 | -2 | 0.564 |
MARK2 |
0.697 | -0.011 | 4 | 0.659 |
IRAK4 |
0.697 | -0.022 | 1 | 0.435 |
MARK1 |
0.697 | -0.001 | 4 | 0.720 |
SSTK |
0.697 | 0.021 | 4 | 0.736 |
LRRK2 |
0.696 | 0.106 | 2 | 0.808 |
BRAF |
0.696 | -0.080 | -4 | 0.629 |
TNIK |
0.696 | 0.059 | 3 | 0.807 |
KHS1 |
0.696 | 0.079 | 1 | 0.455 |
PLK3 |
0.695 | -0.104 | 2 | 0.752 |
HGK |
0.694 | 0.030 | 3 | 0.812 |
NEK11 |
0.694 | -0.013 | 1 | 0.502 |
NEK8 |
0.693 | -0.029 | 2 | 0.772 |
PBK |
0.692 | 0.036 | 1 | 0.416 |
LKB1 |
0.691 | -0.037 | -3 | 0.704 |
TAK1 |
0.691 | 0.016 | 1 | 0.460 |
NEK5 |
0.691 | -0.116 | 1 | 0.456 |
MINK |
0.690 | 0.012 | 1 | 0.447 |
MEKK6 |
0.690 | -0.001 | 1 | 0.473 |
TTBK1 |
0.690 | -0.053 | 2 | 0.589 |
PLK4 |
0.689 | -0.106 | 2 | 0.595 |
FAM20C |
0.689 | -0.014 | 2 | 0.617 |
MAP3K15 |
0.688 | -0.029 | 1 | 0.483 |
IRAK1 |
0.686 | -0.097 | -1 | 0.701 |
EEF2K |
0.685 | 0.021 | 3 | 0.781 |
YSK1 |
0.684 | -0.006 | 2 | 0.768 |
STK33 |
0.684 | -0.016 | 2 | 0.590 |
CAMKK1 |
0.682 | -0.150 | -2 | 0.400 |
CAMKK2 |
0.682 | -0.132 | -2 | 0.390 |
CK2A2 |
0.681 | -0.010 | 1 | 0.374 |
CK1A |
0.681 | 0.112 | -3 | 0.298 |
VRK1 |
0.681 | -0.087 | 2 | 0.805 |
OSR1 |
0.680 | 0.015 | 2 | 0.771 |
NEK4 |
0.680 | -0.118 | 1 | 0.442 |
TAO1 |
0.679 | 0.015 | 1 | 0.461 |
MST2 |
0.678 | -0.114 | 1 | 0.450 |
NEK1 |
0.678 | -0.117 | 1 | 0.449 |
MST1 |
0.677 | -0.072 | 1 | 0.441 |
RIPK2 |
0.677 | -0.108 | 1 | 0.446 |
CK2A1 |
0.677 | -0.009 | 1 | 0.365 |
TTK |
0.674 | -0.013 | -2 | 0.528 |
PLK2 |
0.672 | -0.065 | -3 | 0.580 |
MEK2 |
0.671 | -0.180 | 2 | 0.769 |
CK1G3 |
0.671 | 0.098 | -3 | 0.258 |
YANK3 |
0.671 | 0.009 | 2 | 0.411 |
MYO3B |
0.670 | -0.002 | 2 | 0.784 |
NEK3 |
0.670 | -0.094 | 1 | 0.467 |
ASK1 |
0.669 | -0.059 | 1 | 0.487 |
BIKE |
0.669 | -0.025 | 1 | 0.410 |
ALPHAK3 |
0.668 | -0.005 | -1 | 0.624 |
MYO3A |
0.667 | -0.013 | 1 | 0.464 |
AAK1 |
0.661 | -0.003 | 1 | 0.361 |
CK1G2 |
0.658 | 0.106 | -3 | 0.338 |
PDHK3_TYR |
0.652 | 0.085 | 4 | 0.846 |
LIMK2_TYR |
0.651 | 0.135 | -3 | 0.774 |
TESK1_TYR |
0.651 | 0.117 | 3 | 0.778 |
PDHK4_TYR |
0.650 | 0.101 | 2 | 0.863 |
STLK3 |
0.650 | -0.135 | 1 | 0.443 |
PKMYT1_TYR |
0.648 | 0.124 | 3 | 0.750 |
MAP2K4_TYR |
0.648 | 0.084 | -1 | 0.732 |
PINK1_TYR |
0.647 | 0.091 | 1 | 0.533 |
MAP2K6_TYR |
0.645 | 0.066 | -1 | 0.721 |
BMPR2_TYR |
0.645 | 0.067 | -1 | 0.711 |
YANK2 |
0.644 | -0.007 | 2 | 0.420 |
MAP2K7_TYR |
0.643 | -0.013 | 2 | 0.828 |
PDHK1_TYR |
0.641 | 0.028 | -1 | 0.725 |
LIMK1_TYR |
0.639 | 0.043 | 2 | 0.816 |
RET |
0.638 | -0.061 | 1 | 0.491 |
MST1R |
0.634 | -0.056 | 3 | 0.726 |
NEK10_TYR |
0.634 | -0.035 | 1 | 0.468 |
DDR1 |
0.631 | -0.076 | 4 | 0.784 |
EPHA6 |
0.631 | -0.047 | -1 | 0.697 |
CSF1R |
0.630 | -0.073 | 3 | 0.697 |
TXK |
0.630 | -0.017 | 1 | 0.428 |
TNK2 |
0.629 | -0.038 | 3 | 0.676 |
TNK1 |
0.629 | -0.020 | 3 | 0.700 |
ABL2 |
0.629 | -0.055 | -1 | 0.679 |
TYRO3 |
0.628 | -0.106 | 3 | 0.713 |
YES1 |
0.628 | -0.054 | -1 | 0.750 |
JAK3 |
0.627 | -0.070 | 1 | 0.498 |
FGFR2 |
0.627 | -0.038 | 3 | 0.677 |
JAK2 |
0.626 | -0.144 | 1 | 0.494 |
TYK2 |
0.626 | -0.172 | 1 | 0.473 |
KDR |
0.626 | -0.029 | 3 | 0.649 |
FGR |
0.626 | -0.058 | 1 | 0.437 |
WEE1_TYR |
0.626 | 0.017 | -1 | 0.650 |
EPHB4 |
0.625 | -0.105 | -1 | 0.681 |
LCK |
0.625 | -0.017 | -1 | 0.714 |
ROS1 |
0.625 | -0.107 | 3 | 0.675 |
FLT3 |
0.625 | -0.056 | 3 | 0.732 |
MET |
0.624 | -0.008 | 3 | 0.703 |
DDR2 |
0.624 | -0.005 | 3 | 0.623 |
INSRR |
0.624 | -0.060 | 3 | 0.641 |
KIT |
0.623 | -0.070 | 3 | 0.698 |
FLT1 |
0.623 | -0.024 | -1 | 0.658 |
ABL1 |
0.622 | -0.075 | -1 | 0.683 |
BLK |
0.621 | -0.018 | -1 | 0.710 |
PDGFRB |
0.620 | -0.112 | 3 | 0.715 |
ITK |
0.620 | -0.076 | -1 | 0.702 |
JAK1 |
0.620 | -0.092 | 1 | 0.467 |
TEC |
0.619 | -0.051 | -1 | 0.669 |
FGFR1 |
0.619 | -0.082 | 3 | 0.662 |
FGFR3 |
0.619 | -0.036 | 3 | 0.645 |
HCK |
0.618 | -0.102 | -1 | 0.721 |
TEK |
0.617 | -0.061 | 3 | 0.634 |
TNNI3K_TYR |
0.617 | -0.054 | 1 | 0.477 |
FER |
0.617 | -0.143 | 1 | 0.443 |
EPHA4 |
0.616 | -0.083 | 2 | 0.764 |
BTK |
0.616 | -0.115 | -1 | 0.702 |
SRMS |
0.615 | -0.135 | 1 | 0.429 |
FYN |
0.615 | -0.023 | -1 | 0.705 |
BMX |
0.615 | -0.061 | -1 | 0.625 |
SYK |
0.614 | 0.057 | -1 | 0.608 |
AXL |
0.613 | -0.148 | 3 | 0.666 |
PDGFRA |
0.613 | -0.149 | 3 | 0.710 |
MERTK |
0.612 | -0.135 | 3 | 0.671 |
ERBB2 |
0.612 | -0.081 | 1 | 0.450 |
EPHB1 |
0.611 | -0.166 | 1 | 0.433 |
ALK |
0.611 | -0.116 | 3 | 0.636 |
ZAP70 |
0.609 | 0.052 | -1 | 0.540 |
PTK2B |
0.609 | -0.068 | -1 | 0.684 |
FRK |
0.609 | -0.094 | -1 | 0.710 |
EPHA1 |
0.609 | -0.127 | 3 | 0.688 |
PTK2 |
0.608 | 0.010 | -1 | 0.647 |
EPHB3 |
0.608 | -0.166 | -1 | 0.668 |
PTK6 |
0.608 | -0.163 | -1 | 0.660 |
MATK |
0.607 | -0.063 | -1 | 0.594 |
LTK |
0.607 | -0.134 | 3 | 0.641 |
EGFR |
0.607 | -0.068 | 1 | 0.406 |
EPHB2 |
0.607 | -0.150 | -1 | 0.653 |
FLT4 |
0.607 | -0.117 | 3 | 0.623 |
EPHA7 |
0.605 | -0.122 | 2 | 0.757 |
SRC |
0.604 | -0.066 | -1 | 0.709 |
FGFR4 |
0.603 | -0.074 | -1 | 0.616 |
INSR |
0.603 | -0.132 | 3 | 0.632 |
LYN |
0.603 | -0.108 | 3 | 0.639 |
NTRK1 |
0.602 | -0.194 | -1 | 0.664 |
EPHA3 |
0.602 | -0.131 | 2 | 0.736 |
NTRK2 |
0.600 | -0.189 | 3 | 0.652 |
EPHA8 |
0.600 | -0.096 | -1 | 0.651 |
NTRK3 |
0.599 | -0.152 | -1 | 0.617 |
EPHA5 |
0.598 | -0.122 | 2 | 0.746 |
CSK |
0.596 | -0.151 | 2 | 0.758 |
ERBB4 |
0.596 | -0.039 | 1 | 0.386 |
IGF1R |
0.591 | -0.111 | 3 | 0.574 |
MUSK |
0.591 | -0.120 | 1 | 0.381 |
EPHA2 |
0.589 | -0.117 | -1 | 0.615 |
FES |
0.576 | -0.133 | -1 | 0.613 |