Motif 322 (n=154)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYC7 | ZFP91-CNTF | S146 | ochoa | E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 91 homolog) | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000256|ARBA:ARBA00054990}. |
| A0A0G2JPF8 | HNRNPCL4 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C like 4 | None |
| B2RXH8 | HNRNPCL2 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| B7ZW38 | HNRNPCL3 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 3 | None |
| O15042 | U2SURP | S934 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O43491 | EPB41L2 | S57 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O60812 | HNRNPCL1 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| O75069 | TMCC2 | S78 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75122 | CLASP2 | S537 | psp | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75122 | CLASP2 | S541 | psp | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75494 | SRSF10 | S107 | ochoa | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}. |
| O75494 | SRSF10 | Y113 | ochoa | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}. |
| O95218 | ZRANB2 | S276 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| O95218 | ZRANB2 | S280 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| P07910 | HNRNPC | S171 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P08621 | SNRNP70 | S226 | ochoa|psp | U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}. |
| P0DMR1 | HNRNPCL4 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 4 | None |
| P18615 | NELFE | S179 | ochoa | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P18615 | NELFE | S181 | ochoa | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P18615 | NELFE | S185 | ochoa | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P30414 | NKTR | S515 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30414 | NKTR | S521 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30414 | NKTR | S1309 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30414 | NKTR | S1311 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30414 | NKTR | S1313 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P49760 | CLK2 | S98 | ochoa | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
| P51114 | FXR1 | S432 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P62995 | TRA2B | S264 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| P62995 | TRA2B | S266 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| P62995 | TRA2B | Y268 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| P62995 | TRA2B | S270 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| P78332 | RBM6 | S255 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P84103 | SRSF3 | S122 | psp | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32440474}. |
| P84103 | SRSF3 | S140 | psp | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32440474}. |
| P84103 | SRSF3 | S148 | ochoa | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32440474}. |
| Q01130 | SRSF2 | S128 | psp | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q01130 | SRSF2 | S130 | psp | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q01130 | SRSF2 | S171 | psp | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q07020 | RPL18 | S161 | ochoa | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q07955 | SRSF1 | S199 | ochoa|psp | Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}. |
| Q08170 | SRSF4 | S316 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q08170 | SRSF4 | S456 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q08170 | SRSF4 | S458 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q08170 | SRSF4 | S460 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q08170 | SRSF4 | S462 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q12872 | SFSWAP | S832 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q12872 | SFSWAP | S834 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q12872 | SFSWAP | S838 | ochoa | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}. |
| Q13243 | SRSF5 | S253 | ochoa | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. |
| Q13247 | SRSF6 | S186 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13247 | SRSF6 | S314 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13247 | SRSF6 | S316 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13523 | PRP4K | S431 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13523 | PRP4K | S437 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13523 | PRP4K | T439 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13595 | TRA2A | S20 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Q13595 | TRA2A | T24 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Q13595 | TRA2A | S260 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Q13595 | TRA2A | S262 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Q13595 | TRA2A | Y264 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Q13595 | TRA2A | S266 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Q14004 | CDK13 | S363 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14004 | CDK13 | S397 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14004 | CDK13 | Y399 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14498 | RBM39 | S117 | ochoa | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q14739 | LBR | S70 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q15696 | ZRSR2 | S384 | ochoa | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP) | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}. |
| Q15696 | ZRSR2 | S388 | ochoa | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP) | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}. |
| Q15735 | INPP5J | S902 | ochoa | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56) | Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. {ECO:0000250|UniProtKB:Q9JMC1}. |
| Q15772 | SPEG | S2343 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16629 | SRSF7 | S192 | ochoa | Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) | Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}. |
| Q16629 | SRSF7 | S194 | ochoa | Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) | Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}. |
| Q16629 | SRSF7 | S196 | ochoa | Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) | Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}. |
| Q16629 | SRSF7 | S198 | ochoa | Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) | Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}. |
| Q16630 | CPSF6 | S513 | ochoa | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, PubMed:8626397, PubMed:9659921). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:14690600, PubMed:8626397, PubMed:9659921). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:21295486, PubMed:29276085). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}. |
| Q5T200 | ZC3H13 | S381 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T200 | ZC3H13 | S1264 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5Y3 | CAMSAP1 | S1427 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TZA2 | CROCC | S488 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5TZA2 | CROCC | S494 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VT06 | CEP350 | S473 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VTL8 | PRPF38B | S318 | ochoa | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | May be required for pre-mRNA splicing. {ECO:0000305}. |
| Q5VTL8 | PRPF38B | S320 | ochoa | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | May be required for pre-mRNA splicing. {ECO:0000305}. |
| Q5VTL8 | PRPF38B | S491 | ochoa | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | May be required for pre-mRNA splicing. {ECO:0000305}. |
| Q68DK2 | ZFYVE26 | S765 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
| Q6ZSZ5 | ARHGEF18 | S67 | ochoa | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. |
| Q7Z2W4 | ZC3HAV1 | S235 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z2Z1 | TICRR | S1876 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z6E9 | RBBP6 | Y700 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6E9 | RBBP6 | S1703 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6J6 | FRMD5 | S351 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q86UR5 | RIMS1 | S977 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q8IZP0 | ABI1 | S240 | ochoa | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N1M1 | BEST3 | S400 | ochoa | Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 3) | Ligand-gated anion channel that allows the movement of chloride monoatomic anions across cell membranes when activated by calcium (Ca2+). {ECO:0000269|PubMed:12907679}. |
| Q8N1M1 | BEST3 | S406 | ochoa | Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 3) | Ligand-gated anion channel that allows the movement of chloride monoatomic anions across cell membranes when activated by calcium (Ca2+). {ECO:0000269|PubMed:12907679}. |
| Q8N2M8 | CLASRP | S501 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N2M8 | CLASRP | S645 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N2M8 | CLASRP | S647 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N2M8 | CLASRP | S649 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N5F7 | NKAP | S64 | ochoa | NF-kappa-B-activating protein | Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}. |
| Q8N684 | CPSF7 | S409 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8N684 | CPSF7 | S413 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8N684 | CPSF7 | S415 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8N684 | CPSF7 | S417 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8TF01 | PNISR | S601 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WVS4 | DYNC2I1 | S79 | ochoa | Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:29742051, PubMed:31451806). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Also requires to maintain a functional transition zone (PubMed:30320547). {ECO:0000269|PubMed:23910462, ECO:0000269|PubMed:25205765, ECO:0000269|PubMed:29742051, ECO:0000269|PubMed:30320547, ECO:0000269|PubMed:30649997, ECO:0000269|PubMed:31451806}. |
| Q8WWI1 | LMO7 | S1597 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXA9 | SREK1 | S184 | ochoa | Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) | Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}. |
| Q96JP5 | ZFP91 | S146 | ochoa | E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91) | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}. |
| Q96MU7 | YTHDC1 | S515 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96T23 | RSF1 | S1223 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T58 | SPEN | S749 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T58 | SPEN | S751 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99590 | SCAF11 | S850 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S901 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99959 | PKP2 | S197 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BRL6 | SRSF8 | S196 | ochoa | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}. |
| Q9BRL6 | SRSF8 | S198 | ochoa | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}. |
| Q9BRL6 | SRSF8 | S222 | ochoa | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}. |
| Q9BTC0 | DIDO1 | S2110 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BVG8 | KIFC3 | S805 | ochoa | Kinesin-like protein KIFC3 | Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269|PubMed:19041755}. |
| Q9HC52 | CBX8 | Y106 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
| Q9HCG8 | CWC22 | S64 | ochoa | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q9HCS5 | EPB41L4A | S464 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NRR4 | DROSHA | S255 | psp | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q9NRR4 | DROSHA | T274 | psp | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q9NRU3 | CNNM1 | S729 | ochoa | Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1) | Probable metal transporter. {ECO:0000250}. |
| Q9NS56 | TOPORS | S585 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NYV4 | CDK12 | S341 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NYV4 | CDK12 | S343 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NYV4 | CDK12 | S345 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9UBH6 | XPR1 | S666 | ochoa | Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) (Xenotropic and polytropic retrovirus receptor 1) | Inorganic ion transporter that mediates phosphate ion export across plasma membrane (PubMed:23791524, PubMed:25938945, PubMed:27080106, PubMed:31043717, PubMed:39169184, PubMed:39325866, PubMed:39747008, PubMed:39814721). Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling (PubMed:27080106). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), which are important intracellular signaling molecules involved in regulation of phosphate flux (PubMed:27080106, PubMed:39169184, PubMed:39325866). {ECO:0000269|PubMed:23791524, ECO:0000269|PubMed:25938945, ECO:0000269|PubMed:27080106, ECO:0000269|PubMed:31043717, ECO:0000269|PubMed:39169184, ECO:0000269|PubMed:39325866, ECO:0000269|PubMed:39747008, ECO:0000269|PubMed:39814721}. |
| Q9UDY2 | TJP2 | S168 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UDY2 | TJP2 | S170 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UDY2 | TJP2 | S174 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UDY2 | TJP2 | S232 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHW9 | SLC12A6 | S29 | ochoa | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
| Q9UKJ3 | GPATCH8 | T977 | ochoa | G patch domain-containing protein 8 | None |
| Q9ULI0 | ATAD2B | S1126 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UQ26 | RIMS2 | S1092 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9UQ35 | SRRM2 | S506 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S931 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1693 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1729 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1731 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1830 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1884 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2067 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2W1 | THRAP3 | S119 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y2W1 | THRAP3 | S737 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y388 | RBMX2 | S272 | ochoa | RNA-binding motif protein, X-linked 2 | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9Y5K3 | PCYT1B | S319 | ochoa | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| Q6UN15 | FIP1L1 | Y454 | Sugiyama | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q07020 | RPL18 | T163 | Sugiyama | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-72172 | mRNA Splicing | 1.110223e-16 | 15.955 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.110223e-16 | 15.955 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.110223e-16 | 15.955 |
| R-HSA-72187 | mRNA 3'-end processing | 5.373479e-14 | 13.270 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.402523e-13 | 12.619 |
| R-HSA-8953854 | Metabolism of RNA | 5.566658e-13 | 12.254 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.496698e-08 | 7.347 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.914287e-07 | 6.407 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 6.463490e-06 | 5.190 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 1.392577e-05 | 4.856 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.591927e-05 | 4.586 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.229895e-02 | 1.910 |
| R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 1.644558e-02 | 1.784 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 2.726043e-02 | 1.564 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.520964e-02 | 1.598 |
| R-HSA-74160 | Gene expression (Transcription) | 4.419421e-02 | 1.355 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 9.974164e-02 | 1.001 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.243117e-01 | 0.905 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 1.668783e-01 | 0.778 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 1.668783e-01 | 0.778 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.714797e-01 | 0.766 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.714797e-01 | 0.766 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.211680e-02 | 1.207 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.290603e-01 | 0.640 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.826810e-01 | 0.549 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.061050e-01 | 0.391 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.061050e-01 | 0.391 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.290603e-01 | 0.640 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.247752e-01 | 0.648 |
| R-HSA-156902 | Peptide chain elongation | 4.159289e-01 | 0.381 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.866495e-01 | 0.543 |
| R-HSA-167169 | HIV Transcription Elongation | 2.290603e-01 | 0.640 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.194513e-01 | 0.923 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.985654e-01 | 0.702 |
| R-HSA-5620924 | Intraflagellar transport | 2.665875e-01 | 0.574 |
| R-HSA-167172 | Transcription of the HIV genome | 3.436364e-01 | 0.464 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.651492e-01 | 0.438 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.194513e-01 | 0.923 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.434893e-01 | 0.843 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 1.714797e-01 | 0.766 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 1.339530e-01 | 0.873 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 1.529218e-01 | 0.816 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 1.714797e-01 | 0.766 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.247752e-01 | 0.648 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.387342e-01 | 0.858 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.375604e-01 | 0.624 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 5.378586e-02 | 1.269 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 5.378586e-02 | 1.269 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 1.622516e-01 | 0.790 |
| R-HSA-774815 | Nucleosome assembly | 2.542836e-01 | 0.595 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.542836e-01 | 0.595 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.941127e-01 | 0.712 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.806073e-01 | 0.743 |
| R-HSA-9930044 | Nuclear RNA decay | 1.941127e-01 | 0.712 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.941127e-01 | 0.712 |
| R-HSA-1221632 | Meiotic synapsis | 2.866495e-01 | 0.543 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.984252e-01 | 0.525 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.138276e-01 | 0.503 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 1.575994e-01 | 0.802 |
| R-HSA-68882 | Mitotic Anaphase | 3.755112e-01 | 0.425 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.774830e-01 | 0.423 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.290603e-01 | 0.640 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 9.404524e-02 | 1.027 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.826810e-01 | 0.549 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 5.900448e-02 | 1.229 |
| R-HSA-2028269 | Signaling by Hippo | 1.145643e-01 | 0.941 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 1.434893e-01 | 0.843 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.651492e-01 | 0.438 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.387342e-01 | 0.858 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 1.941127e-01 | 0.712 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.859647e-01 | 0.413 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 1.622516e-01 | 0.790 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.941127e-01 | 0.712 |
| R-HSA-191273 | Cholesterol biosynthesis | 8.239560e-02 | 1.084 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.791023e-01 | 0.421 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.426961e-01 | 0.846 |
| R-HSA-1500620 | Meiosis | 4.027943e-01 | 0.395 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.214029e-01 | 0.493 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.027943e-01 | 0.395 |
| R-HSA-1483191 | Synthesis of PC | 2.625087e-01 | 0.581 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.616128e-01 | 0.442 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.126722e-01 | 0.384 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.476640e-01 | 0.459 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.204665e-01 | 0.657 |
| R-HSA-983712 | Ion channel transport | 3.194358e-01 | 0.496 |
| R-HSA-1640170 | Cell Cycle | 3.769516e-01 | 0.424 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.755104e-01 | 0.756 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.941127e-01 | 0.712 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.896355e-01 | 0.722 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.251596e-01 | 0.488 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.825429e-01 | 0.417 |
| R-HSA-75153 | Apoptotic execution phase | 2.584074e-01 | 0.588 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.223886e-01 | 0.374 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.255920e-01 | 0.371 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.255920e-01 | 0.371 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.287778e-01 | 0.368 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.319461e-01 | 0.365 |
| R-HSA-391251 | Protein folding | 4.319461e-01 | 0.365 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.413471e-01 | 0.355 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.444465e-01 | 0.352 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.444465e-01 | 0.352 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.444465e-01 | 0.352 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.475288e-01 | 0.349 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.505943e-01 | 0.346 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.566748e-01 | 0.340 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.596901e-01 | 0.338 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.626888e-01 | 0.335 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.656711e-01 | 0.332 |
| R-HSA-1483255 | PI Metabolism | 4.656711e-01 | 0.332 |
| R-HSA-192823 | Viral mRNA Translation | 4.686369e-01 | 0.329 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.715866e-01 | 0.326 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.832240e-01 | 0.316 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.832240e-01 | 0.316 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.832240e-01 | 0.316 |
| R-HSA-211000 | Gene Silencing by RNA | 4.832240e-01 | 0.316 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.860935e-01 | 0.313 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.860935e-01 | 0.313 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.889473e-01 | 0.311 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.974150e-01 | 0.303 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.974150e-01 | 0.303 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.974150e-01 | 0.303 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.990988e-01 | 0.302 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.055452e-01 | 0.296 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.112205e-01 | 0.291 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.139363e-01 | 0.289 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.139363e-01 | 0.289 |
| R-HSA-1483257 | Phospholipid metabolism | 5.216080e-01 | 0.283 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.272930e-01 | 0.278 |
| R-HSA-73886 | Chromosome Maintenance | 5.272930e-01 | 0.278 |
| R-HSA-6809371 | Formation of the cornified envelope | 5.351321e-01 | 0.272 |
| R-HSA-194138 | Signaling by VEGF | 5.402866e-01 | 0.267 |
| R-HSA-1474165 | Reproduction | 5.554135e-01 | 0.255 |
| R-HSA-9843745 | Adipogenesis | 5.578864e-01 | 0.253 |
| R-HSA-8957322 | Metabolism of steroids | 5.693732e-01 | 0.245 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.771857e-01 | 0.239 |
| R-HSA-6807070 | PTEN Regulation | 5.795388e-01 | 0.237 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.818789e-01 | 0.235 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.818789e-01 | 0.235 |
| R-HSA-9664407 | Parasite infection | 5.818789e-01 | 0.235 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.842062e-01 | 0.233 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.888223e-01 | 0.230 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.111537e-01 | 0.214 |
| R-HSA-73887 | Death Receptor Signaling | 6.154739e-01 | 0.211 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.176162e-01 | 0.209 |
| R-HSA-1989781 | PPARA activates gene expression | 6.176162e-01 | 0.209 |
| R-HSA-162587 | HIV Life Cycle | 6.218654e-01 | 0.206 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.218654e-01 | 0.206 |
| R-HSA-9711097 | Cellular response to starvation | 6.239725e-01 | 0.205 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.281518e-01 | 0.202 |
| R-HSA-109581 | Apoptosis | 6.322852e-01 | 0.199 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.340094e-01 | 0.198 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.363732e-01 | 0.196 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.363732e-01 | 0.196 |
| R-HSA-5619102 | SLC transporter disorders | 6.424210e-01 | 0.192 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.503304e-01 | 0.187 |
| R-HSA-68886 | M Phase | 6.557795e-01 | 0.183 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.571194e-01 | 0.182 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.580667e-01 | 0.182 |
| R-HSA-168255 | Influenza Infection | 6.674995e-01 | 0.176 |
| R-HSA-2559583 | Cellular Senescence | 6.693549e-01 | 0.174 |
| R-HSA-69275 | G2/M Transition | 6.802745e-01 | 0.167 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.838345e-01 | 0.165 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.838345e-01 | 0.165 |
| R-HSA-5617833 | Cilium Assembly | 6.873553e-01 | 0.163 |
| R-HSA-68877 | Mitotic Prometaphase | 6.925640e-01 | 0.160 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.093143e-01 | 0.149 |
| R-HSA-5357801 | Programmed Cell Death | 7.141610e-01 | 0.146 |
| R-HSA-6805567 | Keratinization | 7.157588e-01 | 0.145 |
| R-HSA-8951664 | Neddylation | 7.386921e-01 | 0.132 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.459222e-01 | 0.127 |
| R-HSA-162906 | HIV Infection | 7.473443e-01 | 0.126 |
| R-HSA-72312 | rRNA processing | 7.543376e-01 | 0.122 |
| R-HSA-112316 | Neuronal System | 7.565625e-01 | 0.121 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.741894e-01 | 0.111 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.877311e-01 | 0.104 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.135044e-01 | 0.090 |
| R-HSA-9658195 | Leishmania infection | 8.135044e-01 | 0.090 |
| R-HSA-422475 | Axon guidance | 8.243841e-01 | 0.084 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.276509e-01 | 0.082 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.503229e-01 | 0.070 |
| R-HSA-9675108 | Nervous system development | 8.505886e-01 | 0.070 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.528371e-01 | 0.069 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.678182e-01 | 0.062 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.037462e-01 | 0.044 |
| R-HSA-72766 | Translation | 9.197434e-01 | 0.036 |
| R-HSA-382551 | Transport of small molecules | 9.206294e-01 | 0.036 |
| R-HSA-556833 | Metabolism of lipids | 9.281478e-01 | 0.032 |
| R-HSA-6798695 | Neutrophil degranulation | 9.315651e-01 | 0.031 |
| R-HSA-212436 | Generic Transcription Pathway | 9.429710e-01 | 0.026 |
| R-HSA-162582 | Signal Transduction | 9.631093e-01 | 0.016 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.719822e-01 | 0.012 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.727768e-01 | 0.012 |
| R-HSA-2262752 | Cellular responses to stress | 9.811378e-01 | 0.008 |
| R-HSA-1280218 | Adaptive Immune System | 9.836195e-01 | 0.007 |
| R-HSA-1643685 | Disease | 9.838750e-01 | 0.007 |
| R-HSA-597592 | Post-translational protein modification | 9.865543e-01 | 0.006 |
| R-HSA-388396 | GPCR downstream signalling | 9.889583e-01 | 0.005 |
| R-HSA-9824446 | Viral Infection Pathways | 9.891568e-01 | 0.005 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.901153e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.931939e-01 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 9.949722e-01 | 0.002 |
| R-HSA-168249 | Innate Immune System | 9.962261e-01 | 0.002 |
| R-HSA-1266738 | Developmental Biology | 9.963767e-01 | 0.002 |
| R-HSA-5663205 | Infectious disease | 9.969695e-01 | 0.001 |
| R-HSA-168256 | Immune System | 9.999462e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999931e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
SRPK1 |
0.868 | 0.682 | -3 | 0.908 |
CLK2 |
0.865 | 0.642 | -3 | 0.892 |
SRPK2 |
0.861 | 0.630 | -3 | 0.885 |
CLK3 |
0.858 | 0.578 | 1 | 0.849 |
SRPK3 |
0.851 | 0.654 | -3 | 0.891 |
CLK4 |
0.835 | 0.506 | -3 | 0.892 |
CLK1 |
0.834 | 0.528 | -3 | 0.869 |
HIPK2 |
0.833 | 0.463 | 1 | 0.862 |
PIM3 |
0.831 | 0.427 | -3 | 0.909 |
RSK2 |
0.830 | 0.440 | -3 | 0.912 |
PIM1 |
0.830 | 0.457 | -3 | 0.906 |
CDK10 |
0.828 | 0.491 | 1 | 0.823 |
HIPK1 |
0.828 | 0.509 | 1 | 0.913 |
PRKX |
0.826 | 0.394 | -3 | 0.862 |
RSK4 |
0.826 | 0.436 | -3 | 0.910 |
HIPK4 |
0.824 | 0.428 | 1 | 0.927 |
DYRK3 |
0.823 | 0.503 | 1 | 0.927 |
DYRK2 |
0.822 | 0.437 | 1 | 0.908 |
CDKL5 |
0.821 | 0.410 | -3 | 0.912 |
CDKL1 |
0.820 | 0.465 | -3 | 0.909 |
PIM2 |
0.820 | 0.483 | -3 | 0.889 |
P90RSK |
0.819 | 0.411 | -3 | 0.908 |
PKACB |
0.819 | 0.352 | -2 | 0.684 |
NDR1 |
0.818 | 0.355 | -3 | 0.887 |
RSK3 |
0.818 | 0.396 | -3 | 0.897 |
NDR2 |
0.817 | 0.271 | -3 | 0.891 |
PKACG |
0.816 | 0.328 | -2 | 0.743 |
DYRK4 |
0.815 | 0.410 | 1 | 0.844 |
AKT2 |
0.814 | 0.425 | -3 | 0.877 |
ICK |
0.814 | 0.419 | -3 | 0.907 |
AURC |
0.813 | 0.269 | -2 | 0.669 |
COT |
0.813 | 0.214 | 2 | 0.780 |
DYRK1B |
0.813 | 0.419 | 1 | 0.860 |
PRKD2 |
0.813 | 0.340 | -3 | 0.885 |
CDK1 |
0.812 | 0.327 | 1 | 0.818 |
P70S6KB |
0.811 | 0.374 | -3 | 0.894 |
PKCG |
0.811 | 0.347 | 2 | 0.713 |
MOK |
0.810 | 0.518 | 1 | 0.926 |
CDK13 |
0.810 | 0.348 | 1 | 0.822 |
PKCD |
0.809 | 0.332 | 2 | 0.737 |
PKN2 |
0.809 | 0.361 | -3 | 0.856 |
CDK12 |
0.809 | 0.361 | 1 | 0.804 |
PKCB |
0.808 | 0.332 | 2 | 0.692 |
NLK |
0.808 | 0.358 | 1 | 0.877 |
NUAK2 |
0.808 | 0.361 | -3 | 0.887 |
MSK2 |
0.808 | 0.340 | -3 | 0.906 |
WNK1 |
0.807 | 0.336 | -2 | 0.830 |
MSK1 |
0.807 | 0.341 | -3 | 0.898 |
MAK |
0.807 | 0.441 | -2 | 0.670 |
HIPK3 |
0.806 | 0.448 | 1 | 0.880 |
DYRK1A |
0.806 | 0.423 | 1 | 0.868 |
CDK5 |
0.806 | 0.334 | 1 | 0.847 |
MNK1 |
0.806 | 0.306 | -2 | 0.766 |
SKMLCK |
0.805 | 0.273 | -2 | 0.833 |
PKCA |
0.805 | 0.316 | 2 | 0.696 |
MAPKAPK2 |
0.804 | 0.301 | -3 | 0.888 |
CAMK1B |
0.804 | 0.337 | -3 | 0.873 |
PKCE |
0.804 | 0.405 | 2 | 0.702 |
MTOR |
0.804 | 0.149 | 1 | 0.745 |
LATS2 |
0.803 | 0.205 | -5 | 0.776 |
PKN3 |
0.802 | 0.281 | -3 | 0.871 |
MST4 |
0.802 | 0.232 | 2 | 0.773 |
KIS |
0.802 | 0.259 | 1 | 0.842 |
PKCZ |
0.802 | 0.313 | 2 | 0.724 |
PAK1 |
0.802 | 0.249 | -2 | 0.763 |
CDK9 |
0.801 | 0.308 | 1 | 0.823 |
PKACA |
0.801 | 0.324 | -2 | 0.637 |
CAMK2A |
0.801 | 0.257 | 2 | 0.789 |
AKT1 |
0.801 | 0.390 | -3 | 0.879 |
MAPKAPK3 |
0.801 | 0.296 | -3 | 0.877 |
PKCH |
0.801 | 0.327 | 2 | 0.688 |
CAMK1G |
0.800 | 0.385 | -3 | 0.880 |
IRE1 |
0.799 | 0.324 | 1 | 0.777 |
PKG2 |
0.799 | 0.283 | -2 | 0.677 |
AKT3 |
0.799 | 0.403 | -3 | 0.859 |
PRKD3 |
0.799 | 0.337 | -3 | 0.874 |
CAMLCK |
0.798 | 0.298 | -2 | 0.804 |
AURB |
0.798 | 0.238 | -2 | 0.670 |
SGK3 |
0.798 | 0.351 | -3 | 0.877 |
NIK |
0.798 | 0.370 | -3 | 0.838 |
CHAK2 |
0.798 | 0.166 | -1 | 0.867 |
MYLK4 |
0.798 | 0.307 | -2 | 0.756 |
SGK1 |
0.797 | 0.413 | -3 | 0.849 |
CDK14 |
0.797 | 0.333 | 1 | 0.829 |
MOS |
0.797 | 0.120 | 1 | 0.780 |
CDK3 |
0.797 | 0.264 | 1 | 0.779 |
CDK18 |
0.797 | 0.271 | 1 | 0.803 |
CDK7 |
0.796 | 0.252 | 1 | 0.835 |
CDK4 |
0.795 | 0.391 | 1 | 0.803 |
LATS1 |
0.795 | 0.250 | -3 | 0.891 |
DAPK2 |
0.794 | 0.297 | -3 | 0.872 |
MNK2 |
0.794 | 0.216 | -2 | 0.764 |
PRKD1 |
0.793 | 0.186 | -3 | 0.886 |
PAK3 |
0.792 | 0.208 | -2 | 0.754 |
PKCI |
0.792 | 0.337 | 2 | 0.705 |
CDK6 |
0.792 | 0.378 | 1 | 0.811 |
PASK |
0.791 | 0.334 | -3 | 0.904 |
P70S6K |
0.791 | 0.362 | -3 | 0.874 |
AMPKA1 |
0.791 | 0.235 | -3 | 0.873 |
IRE2 |
0.791 | 0.280 | 2 | 0.683 |
DCAMKL1 |
0.791 | 0.332 | -3 | 0.874 |
PKCT |
0.791 | 0.321 | 2 | 0.681 |
PRPK |
0.791 | 0.000 | -1 | 0.789 |
CDC7 |
0.791 | 0.002 | 1 | 0.711 |
AMPKA2 |
0.790 | 0.257 | -3 | 0.881 |
RAF1 |
0.790 | 0.049 | 1 | 0.708 |
CDK8 |
0.789 | 0.203 | 1 | 0.822 |
CDK19 |
0.789 | 0.217 | 1 | 0.802 |
CDK17 |
0.789 | 0.255 | 1 | 0.766 |
GRK1 |
0.789 | 0.108 | -2 | 0.792 |
MLK3 |
0.788 | 0.137 | 2 | 0.714 |
P38G |
0.788 | 0.265 | 1 | 0.760 |
PAK2 |
0.788 | 0.201 | -2 | 0.754 |
ERK5 |
0.788 | 0.104 | 1 | 0.809 |
AURA |
0.788 | 0.175 | -2 | 0.651 |
GCN2 |
0.787 | -0.040 | 2 | 0.757 |
MRCKB |
0.787 | 0.381 | -3 | 0.867 |
CAMK2B |
0.787 | 0.167 | 2 | 0.749 |
PHKG1 |
0.787 | 0.222 | -3 | 0.879 |
CAMK4 |
0.786 | 0.196 | -3 | 0.858 |
NEK6 |
0.786 | 0.011 | -2 | 0.781 |
JNK2 |
0.786 | 0.263 | 1 | 0.795 |
JNK3 |
0.786 | 0.253 | 1 | 0.817 |
CAMK2G |
0.786 | -0.000 | 2 | 0.778 |
CHAK1 |
0.786 | 0.201 | 2 | 0.733 |
ATR |
0.785 | 0.025 | 1 | 0.726 |
IKKB |
0.785 | -0.028 | -2 | 0.683 |
GRK5 |
0.785 | 0.007 | -3 | 0.756 |
CDK2 |
0.785 | 0.188 | 1 | 0.848 |
MELK |
0.785 | 0.255 | -3 | 0.869 |
MLK1 |
0.784 | 0.072 | 2 | 0.761 |
CAMK2D |
0.784 | 0.125 | -3 | 0.860 |
ROCK2 |
0.784 | 0.383 | -3 | 0.878 |
BRSK1 |
0.784 | 0.208 | -3 | 0.876 |
RIPK1 |
0.784 | 0.185 | 1 | 0.752 |
MARK4 |
0.784 | 0.065 | 4 | 0.673 |
PKR |
0.784 | 0.273 | 1 | 0.794 |
CDK16 |
0.783 | 0.258 | 1 | 0.780 |
SMMLCK |
0.783 | 0.324 | -3 | 0.878 |
MRCKA |
0.783 | 0.351 | -3 | 0.870 |
CAMK1D |
0.783 | 0.334 | -3 | 0.845 |
RIPK3 |
0.783 | 0.060 | 3 | 0.571 |
TSSK1 |
0.783 | 0.183 | -3 | 0.876 |
ERK1 |
0.782 | 0.240 | 1 | 0.793 |
GRK7 |
0.782 | 0.118 | 1 | 0.674 |
GSK3A |
0.782 | 0.184 | 4 | 0.530 |
SIK |
0.782 | 0.215 | -3 | 0.876 |
BMPR2 |
0.782 | -0.057 | -2 | 0.787 |
DLK |
0.782 | 0.108 | 1 | 0.712 |
DMPK1 |
0.781 | 0.413 | -3 | 0.871 |
ERK2 |
0.781 | 0.241 | 1 | 0.831 |
QSK |
0.781 | 0.162 | 4 | 0.650 |
P38A |
0.781 | 0.229 | 1 | 0.841 |
DSTYK |
0.781 | -0.031 | 2 | 0.825 |
TSSK2 |
0.780 | 0.144 | -5 | 0.785 |
PDHK4 |
0.780 | -0.164 | 1 | 0.756 |
DAPK3 |
0.780 | 0.323 | -3 | 0.894 |
TGFBR2 |
0.780 | 0.022 | -2 | 0.709 |
ULK2 |
0.780 | -0.074 | 2 | 0.718 |
CHK2 |
0.780 | 0.377 | -3 | 0.837 |
WNK3 |
0.780 | 0.044 | 1 | 0.713 |
QIK |
0.779 | 0.159 | -3 | 0.850 |
HUNK |
0.779 | 0.025 | 2 | 0.741 |
NUAK1 |
0.778 | 0.202 | -3 | 0.871 |
PAK6 |
0.778 | 0.144 | -2 | 0.692 |
DAPK1 |
0.778 | 0.315 | -3 | 0.897 |
MST3 |
0.777 | 0.227 | 2 | 0.783 |
HASPIN |
0.777 | 0.347 | -1 | 0.844 |
WNK4 |
0.777 | 0.238 | -2 | 0.829 |
ROCK1 |
0.777 | 0.389 | -3 | 0.866 |
MAPKAPK5 |
0.777 | 0.229 | -3 | 0.869 |
NEK7 |
0.777 | -0.077 | -3 | 0.733 |
PKN1 |
0.777 | 0.315 | -3 | 0.869 |
P38B |
0.777 | 0.219 | 1 | 0.798 |
PHKG2 |
0.777 | 0.260 | -3 | 0.843 |
NIM1 |
0.777 | 0.076 | 3 | 0.619 |
DRAK1 |
0.776 | 0.125 | 1 | 0.627 |
MLK4 |
0.776 | 0.092 | 2 | 0.685 |
GRK6 |
0.776 | 0.004 | 1 | 0.714 |
SBK |
0.776 | 0.366 | -3 | 0.818 |
CRIK |
0.776 | 0.408 | -3 | 0.889 |
TBK1 |
0.775 | -0.126 | 1 | 0.600 |
MARK3 |
0.775 | 0.102 | 4 | 0.616 |
PRP4 |
0.775 | 0.152 | -3 | 0.640 |
BRSK2 |
0.774 | 0.139 | -3 | 0.853 |
MPSK1 |
0.774 | 0.210 | 1 | 0.788 |
TAO3 |
0.773 | 0.191 | 1 | 0.692 |
ANKRD3 |
0.773 | 0.019 | 1 | 0.741 |
DCAMKL2 |
0.773 | 0.211 | -3 | 0.865 |
IKKE |
0.773 | -0.130 | 1 | 0.594 |
SNRK |
0.772 | 0.125 | 2 | 0.652 |
PINK1 |
0.772 | 0.127 | 1 | 0.863 |
PDHK1 |
0.772 | -0.189 | 1 | 0.728 |
MASTL |
0.772 | -0.099 | -2 | 0.761 |
MLK2 |
0.771 | -0.040 | 2 | 0.747 |
NEK9 |
0.771 | -0.052 | 2 | 0.753 |
BUB1 |
0.771 | 0.260 | -5 | 0.747 |
STK33 |
0.770 | 0.169 | 2 | 0.617 |
VRK2 |
0.770 | 0.141 | 1 | 0.819 |
CAMK1A |
0.770 | 0.323 | -3 | 0.839 |
GSK3B |
0.770 | 0.121 | 4 | 0.524 |
PAK5 |
0.770 | 0.166 | -2 | 0.664 |
CK1E |
0.770 | 0.072 | -3 | 0.520 |
IRAK4 |
0.769 | 0.190 | 1 | 0.745 |
KHS2 |
0.769 | 0.346 | 1 | 0.679 |
BMPR1B |
0.769 | 0.041 | 1 | 0.674 |
ERK7 |
0.769 | 0.167 | 2 | 0.571 |
NEK2 |
0.769 | 0.032 | 2 | 0.751 |
TTBK2 |
0.769 | -0.030 | 2 | 0.648 |
BCKDK |
0.769 | -0.117 | -1 | 0.719 |
FAM20C |
0.767 | 0.019 | 2 | 0.603 |
GRK4 |
0.767 | -0.066 | -2 | 0.787 |
SSTK |
0.767 | 0.156 | 4 | 0.639 |
PAK4 |
0.766 | 0.155 | -2 | 0.664 |
GCK |
0.766 | 0.228 | 1 | 0.683 |
IKKA |
0.766 | -0.109 | -2 | 0.671 |
HPK1 |
0.765 | 0.262 | 1 | 0.669 |
LRRK2 |
0.765 | 0.333 | 2 | 0.791 |
ULK1 |
0.765 | -0.139 | -3 | 0.671 |
MEK5 |
0.765 | 0.096 | 2 | 0.761 |
JNK1 |
0.765 | 0.212 | 1 | 0.791 |
YSK4 |
0.765 | -0.035 | 1 | 0.647 |
TNIK |
0.764 | 0.252 | 3 | 0.832 |
SLK |
0.764 | 0.153 | -2 | 0.690 |
P38D |
0.764 | 0.215 | 1 | 0.764 |
ATM |
0.764 | -0.036 | 1 | 0.650 |
CK1D |
0.763 | 0.083 | -3 | 0.475 |
TAO2 |
0.763 | 0.202 | 2 | 0.777 |
PERK |
0.762 | 0.030 | -2 | 0.741 |
GAK |
0.762 | 0.181 | 1 | 0.779 |
CHK1 |
0.762 | 0.065 | -3 | 0.840 |
KHS1 |
0.762 | 0.269 | 1 | 0.666 |
DNAPK |
0.762 | -0.005 | 1 | 0.579 |
MEK1 |
0.762 | -0.073 | 2 | 0.778 |
GRK2 |
0.762 | 0.010 | -2 | 0.682 |
LOK |
0.762 | 0.194 | -2 | 0.725 |
MARK1 |
0.761 | 0.057 | 4 | 0.638 |
HRI |
0.761 | 0.034 | -2 | 0.752 |
ALK4 |
0.761 | -0.058 | -2 | 0.733 |
MEKK3 |
0.760 | 0.040 | 1 | 0.695 |
EEF2K |
0.760 | 0.253 | 3 | 0.846 |
CK1A2 |
0.760 | 0.067 | -3 | 0.484 |
PLK1 |
0.759 | -0.081 | -2 | 0.708 |
HGK |
0.759 | 0.217 | 3 | 0.831 |
NEK5 |
0.758 | 0.033 | 1 | 0.731 |
MARK2 |
0.758 | 0.018 | 4 | 0.569 |
ZAK |
0.758 | -0.003 | 1 | 0.658 |
TLK2 |
0.758 | -0.088 | 1 | 0.706 |
NEK8 |
0.758 | 0.098 | 2 | 0.763 |
MEKK1 |
0.757 | -0.017 | 1 | 0.704 |
MEKK2 |
0.757 | 0.029 | 2 | 0.733 |
SMG1 |
0.755 | -0.078 | 1 | 0.686 |
PKG1 |
0.755 | 0.225 | -2 | 0.598 |
PLK3 |
0.755 | -0.084 | 2 | 0.746 |
TGFBR1 |
0.755 | -0.073 | -2 | 0.704 |
PDK1 |
0.755 | 0.145 | 1 | 0.686 |
ALK2 |
0.755 | -0.044 | -2 | 0.723 |
TLK1 |
0.754 | -0.029 | -2 | 0.746 |
CK1G1 |
0.754 | 0.024 | -3 | 0.503 |
LKB1 |
0.753 | 0.033 | -3 | 0.733 |
PBK |
0.752 | 0.127 | 1 | 0.707 |
MINK |
0.752 | 0.152 | 1 | 0.667 |
CAMKK1 |
0.751 | -0.023 | -2 | 0.680 |
GRK3 |
0.750 | 0.011 | -2 | 0.662 |
CAMKK2 |
0.750 | -0.018 | -2 | 0.677 |
ACVR2A |
0.749 | -0.090 | -2 | 0.682 |
NEK11 |
0.749 | -0.016 | 1 | 0.671 |
ACVR2B |
0.749 | -0.088 | -2 | 0.698 |
MYO3B |
0.748 | 0.239 | 2 | 0.760 |
MEKK6 |
0.748 | 0.080 | 1 | 0.686 |
BRAF |
0.748 | -0.085 | -4 | 0.728 |
PLK4 |
0.748 | -0.097 | 2 | 0.583 |
YSK1 |
0.746 | 0.131 | 2 | 0.739 |
BMPR1A |
0.745 | -0.034 | 1 | 0.646 |
MST1 |
0.744 | 0.045 | 1 | 0.668 |
OSR1 |
0.744 | 0.120 | 2 | 0.731 |
MAP3K15 |
0.744 | 0.026 | 1 | 0.646 |
NEK4 |
0.744 | -0.010 | 1 | 0.692 |
CK2A2 |
0.743 | -0.001 | 1 | 0.603 |
VRK1 |
0.743 | 0.081 | 2 | 0.725 |
TAK1 |
0.743 | 0.048 | 1 | 0.677 |
NEK1 |
0.742 | 0.054 | 1 | 0.713 |
YANK3 |
0.742 | 0.042 | 2 | 0.418 |
CK2A1 |
0.739 | 0.012 | 1 | 0.584 |
MST2 |
0.739 | -0.058 | 1 | 0.678 |
LIMK2_TYR |
0.738 | 0.299 | -3 | 0.806 |
IRAK1 |
0.737 | -0.105 | -1 | 0.725 |
TAO1 |
0.737 | 0.135 | 1 | 0.621 |
PDHK3_TYR |
0.737 | 0.219 | 4 | 0.779 |
MYO3A |
0.735 | 0.142 | 1 | 0.729 |
TTBK1 |
0.735 | -0.119 | 2 | 0.587 |
TESK1_TYR |
0.734 | 0.240 | 3 | 0.747 |
PDHK4_TYR |
0.733 | 0.173 | 2 | 0.834 |
CK1A |
0.730 | 0.048 | -3 | 0.395 |
PKMYT1_TYR |
0.730 | 0.169 | 3 | 0.698 |
TTK |
0.729 | 0.031 | -2 | 0.736 |
BIKE |
0.729 | 0.063 | 1 | 0.695 |
PINK1_TYR |
0.728 | 0.231 | 1 | 0.761 |
MAP2K6_TYR |
0.728 | 0.110 | -1 | 0.797 |
PLK2 |
0.727 | -0.077 | -3 | 0.613 |
MAP2K4_TYR |
0.727 | 0.103 | -1 | 0.788 |
LIMK1_TYR |
0.727 | 0.184 | 2 | 0.780 |
RIPK2 |
0.726 | -0.114 | 1 | 0.604 |
MAP2K7_TYR |
0.725 | 0.065 | 2 | 0.805 |
WEE1_TYR |
0.724 | 0.250 | -1 | 0.699 |
NEK3 |
0.724 | -0.049 | 1 | 0.658 |
MEK2 |
0.723 | -0.185 | 2 | 0.724 |
BMPR2_TYR |
0.721 | 0.054 | -1 | 0.755 |
PDHK1_TYR |
0.721 | 0.013 | -1 | 0.789 |
ASK1 |
0.720 | -0.037 | 1 | 0.634 |
ALPHAK3 |
0.720 | 0.001 | -1 | 0.711 |
AAK1 |
0.716 | 0.081 | 1 | 0.619 |
RET |
0.714 | -0.022 | 1 | 0.708 |
TNNI3K_TYR |
0.713 | 0.121 | 1 | 0.734 |
TNK1 |
0.712 | 0.102 | 3 | 0.636 |
CK1G3 |
0.711 | 0.044 | -3 | 0.354 |
YANK2 |
0.709 | 0.002 | 2 | 0.441 |
TNK2 |
0.708 | 0.006 | 3 | 0.553 |
DDR1 |
0.707 | -0.053 | 4 | 0.693 |
MST1R |
0.707 | -0.079 | 3 | 0.645 |
EPHA6 |
0.706 | -0.041 | -1 | 0.723 |
NEK10_TYR |
0.705 | 0.002 | 1 | 0.583 |
FGR |
0.705 | -0.051 | 1 | 0.727 |
TYRO3 |
0.704 | -0.094 | 3 | 0.657 |
ROS1 |
0.703 | -0.103 | 3 | 0.622 |
KDR |
0.702 | -0.024 | 3 | 0.569 |
DDR2 |
0.702 | 0.066 | 3 | 0.530 |
TYK2 |
0.702 | -0.154 | 1 | 0.692 |
STLK3 |
0.702 | -0.141 | 1 | 0.629 |
ABL2 |
0.701 | -0.059 | -1 | 0.719 |
EPHB4 |
0.701 | -0.112 | -1 | 0.707 |
JAK3 |
0.700 | -0.084 | 1 | 0.671 |
YES1 |
0.699 | -0.078 | -1 | 0.722 |
CSF1R |
0.699 | -0.119 | 3 | 0.624 |
TXK |
0.698 | -0.034 | 1 | 0.692 |
FGFR2 |
0.698 | -0.093 | 3 | 0.591 |
PDGFRB |
0.696 | -0.105 | 3 | 0.647 |
ABL1 |
0.696 | -0.088 | -1 | 0.709 |
ITK |
0.696 | -0.041 | -1 | 0.667 |
INSRR |
0.696 | -0.109 | 3 | 0.570 |
FLT1 |
0.695 | -0.049 | -1 | 0.721 |
FLT3 |
0.695 | -0.057 | 3 | 0.670 |
CK1G2 |
0.695 | 0.039 | -3 | 0.433 |
JAK2 |
0.695 | -0.225 | 1 | 0.684 |
KIT |
0.693 | -0.107 | 3 | 0.623 |
EPHA4 |
0.693 | -0.102 | 2 | 0.761 |
LCK |
0.692 | -0.048 | -1 | 0.670 |
MET |
0.692 | -0.082 | 3 | 0.600 |
BLK |
0.690 | -0.043 | -1 | 0.668 |
FER |
0.690 | -0.212 | 1 | 0.719 |
BMX |
0.690 | -0.033 | -1 | 0.610 |
MATK |
0.689 | -0.045 | -1 | 0.689 |
TEK |
0.689 | -0.136 | 3 | 0.564 |
JAK1 |
0.687 | -0.109 | 1 | 0.623 |
PDGFRA |
0.686 | -0.169 | 3 | 0.652 |
TEC |
0.686 | -0.089 | -1 | 0.607 |
HCK |
0.686 | -0.161 | -1 | 0.669 |
FGFR1 |
0.685 | -0.178 | 3 | 0.562 |
FGFR3 |
0.685 | -0.120 | 3 | 0.558 |
AXL |
0.685 | -0.176 | 3 | 0.570 |
BTK |
0.684 | -0.143 | -1 | 0.648 |
SRMS |
0.684 | -0.188 | 1 | 0.697 |
EPHB1 |
0.683 | -0.207 | 1 | 0.682 |
MERTK |
0.683 | -0.172 | 3 | 0.576 |
PTK6 |
0.683 | -0.186 | -1 | 0.660 |
EPHB3 |
0.683 | -0.199 | -1 | 0.679 |
FLT4 |
0.681 | -0.151 | 3 | 0.563 |
EPHB2 |
0.681 | -0.187 | -1 | 0.670 |
LTK |
0.681 | -0.158 | 3 | 0.548 |
ALK |
0.681 | -0.170 | 3 | 0.543 |
ERBB2 |
0.680 | -0.157 | 1 | 0.648 |
FYN |
0.680 | -0.083 | -1 | 0.638 |
EPHA3 |
0.679 | -0.163 | 2 | 0.728 |
EPHA1 |
0.678 | -0.156 | 3 | 0.583 |
EPHA7 |
0.678 | -0.152 | 2 | 0.751 |
INSR |
0.675 | -0.183 | 3 | 0.564 |
FRK |
0.675 | -0.138 | -1 | 0.676 |
PTK2B |
0.675 | -0.129 | -1 | 0.655 |
PTK2 |
0.674 | -0.043 | -1 | 0.631 |
NTRK1 |
0.674 | -0.260 | -1 | 0.732 |
SYK |
0.672 | -0.042 | -1 | 0.633 |
EPHA5 |
0.672 | -0.150 | 2 | 0.744 |
NTRK2 |
0.672 | -0.258 | 3 | 0.575 |
LYN |
0.671 | -0.169 | 3 | 0.574 |
EPHA8 |
0.670 | -0.152 | -1 | 0.656 |
SRC |
0.670 | -0.136 | -1 | 0.648 |
CSK |
0.669 | -0.174 | 2 | 0.750 |
MUSK |
0.668 | -0.090 | 1 | 0.568 |
NTRK3 |
0.668 | -0.210 | -1 | 0.697 |
EGFR |
0.668 | -0.121 | 1 | 0.565 |
FGFR4 |
0.666 | -0.140 | -1 | 0.679 |
ZAP70 |
0.661 | -0.021 | -1 | 0.604 |
IGF1R |
0.660 | -0.175 | 3 | 0.502 |
EPHA2 |
0.659 | -0.156 | -1 | 0.632 |
ERBB4 |
0.658 | -0.104 | 1 | 0.585 |
FES |
0.639 | -0.205 | -1 | 0.597 |